Ongoing serious, non-healing wound, ulcer, or bone fracture
History of serious or non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, skin ulcer, or bone fracture
Prior osteoporotic fracture
Serious nonhealing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or bone fracture within  months prior to enrollment
Serious, non-healing wound, active ulcer, or untreated bone fracture
Serious, non-healing wound, ulcer, or bone fracture.
Serious or non-healing wound, peptic ulcer, or bone fracture within  days prior to initiation of study treatment;
Patients with serious or non-healing wound, ulcer, or bone fracture
Patients with a serious or nonhealing wound, ulcer, or bone fracture within  days prior to enrollment
Serious or non-healing wound, ulcer, or bone fracture.
Any patient with a current non-healing wound, bone fracture, or skin ulcer is excluded
Presence of serious or nonhealing wound, ulcer, or bone fracture within  days prior to enrollment
Serious, non-healing wound; active ulcer; or untreated bone fracture
Patients with serious or non-healing wound, ulcer, or bone fracture.
Patients who have non-healing wound, unhealed or incompletely healed fracture, or a compound (open) bone fracture at the time of enrollment are not eligible
Ongoing serious, non-healing wound, ulcer, or bone fracture.
Patients with a serious non-healing wound, active ulcer, or untreated bone fracture
Any severe or poorly controlled systemic disease (e.g., hypertension; clinically significant cardiovascular, pulmonary, or metabolic disease, disorders of wound healing, ulcer or bone fracture)
Serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound or ulcer; bone fracture within  months prior to study entry
Serious or non-healing wound, ulcer or bone fracture
History or evidence of arterial thrombotic or hemorrhagic disorders within  months before proposed start of treatment, non-healing wound, ulcer, or bone fracture
Patients who have a non-healing wound, ulcer, or bone fracture.
Serious non-healing wound, ulcer or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture.
Non-healing wound, ulcer, non-healing traumatic bone fracture, or abscess within  days of enrollment\r\n* Nondisplaced, uncomplicated pathologic fracture due to tumor may be eligible provided adequately treated with radiation, surgery or other treatments with full recovery based upon investigator assessment
Serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture.
Serious non-healing wound, ulcer or bone fracture
Non-healing wound, ulcer, or bone fracture
Patients who have serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture.
have any non-healing wound, fracture, or ulcer within  days prior to the planned start of study treatment;
(Bevacizumab-related exclusion) History of abdominal fistula or gastrointestinal perforation within  months prior to the first study treatment. Serious, non-healing wound, active ulcer, or untreated bone fracture (adjuvant trials: bone fractures must be healed)
Serious or non-healing wound, ulcer, or bone fracture.
Serious, non-healing wound, active ulcer, or untreated bone fracture, including tumor-related pathological fracture
History of abdominal fistula or gastrointestinal perforation =<  months before cycle , day ; serious non-healing wound, active ulcer, or untreated bone fracture (adjuvant trials: bone fractures must be healed)
Non-healing wound, ulcer, or bone fracture
Participant has a serious, non-healing wound, ulcer, or bone fracture
Active wound, a serious or non-healing wound, an active ulcer or untreated bone fracture
Non-healing wound, bone fracture, or skin ulcer
mCRPC EXPANSION COHORT: Other clinically significant disorders such as:\r\n* Active infection requiring intravenous treatment within  days of starting protocol treatment\r\n* Serious non-healing wound/ulcer/bone fracture (excluding stable compression fracture) within  days before the first dose of study treatment
The patient has a serious or nonhealing wound, ulcer, or bone fracture within  days prior to enrollment
Non-healing wound, ulcer, or bone fracture
Non-healing wound, active peptic ulcer or bone fracture
The patient has a serious or non-healing wound, ulcer, or bone fracture within  days prior to enrollment
Subject has a serious, non-healing wound, ulcer, or bone fracture
Patients who have serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Serious non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Serious non-healing wound, active peptic ulcer, or untreated bone fracture
Serious or non-healing wound, ulcer or bone fracture
The patient has a serious or non-healing wound, ulcer, or bone fracture within  days prior to first dose of protocol therapy
Serious, non-healing wound, active ulcer, or untreated bone fracture
A serious, non healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture; any bone fractures must be healed
Serious, non-healing wound, ulcer, or bone fracture
Non healing wound, ulcer or bone fracture
Non-healing serious wound, ulcer, or bone fracture unrelated to the primary tumor
Non?healing wound, ulcer, or bone fracture
Presence of a serious nonhealing wound, ulcer, or bone fracture
Ongoing significant, uncontrolled medical condition including: o Serious, non-healing wound, skin ulcer (of any grade), or bone fracture.
History of serious or non-healing wound, ulcer, or bone fracture
Patients with a non-healing wound, fracture, or ulcer
Non-healing wound, ulcer or bone fracture
Patients with serious non-healing wound, ulcer, or bone fracture within  days before registration; patients should not have had any major surgical procedures within  days of registration
Serious, non-healing wound, active ulcer, or untreated bone fracture
Subjects with a non-healing serious wound, ulcer, or bone fracture unrelated to the primary tumor
Patients who have a serious or non-healing wound, ulcer, or bone fracture at the time of study enrollment are not eligible
Serious or non-healing wound, ulcer or bone fracture
Serious non-healing wound, ulcer, bone fracture, or abscess
Serious, non-healing wound, ulcer, or bone fracture
Patients with a serious or non-healing wound, ulcer, or bone fracture are not eligible for this study
Serious, non-healing wound, ulcer, or bone fracture
The participant has a serious nonhealing: (a) wound, (b) peptic ulcer, or (c) bone fracture.
Serious, non-healing wound, infection, ulcer, bone fracture, or uncontrolled seizures
Patients with a serious or nonhealing wound, ulcer, or bone fracture within  days prior to enrollment
Patient must not have serious or non-healing wound, ulcer, or bone fracture at the time of randomization
Have had a serious or non-healing wound, ulcer, or bone fracture within  days prior to enrollment.
Serious non-healing wound, ulcer or bone fracture
Patients with serous non-healing wound, ulcer, or bone fracture.
Serious, non-healing wound, ulcer, or bone fracture requiring surgical intervention.
Serious non-healing wound, ulcer, or bone fracture
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
Non-healing wound, ulcer or bone fracture
Has history of a non-healing wound, ulcer, or bone fracture within  days ( months) prior to entry in to the trial
Serious non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture as judged by treating physician
Serious, non-healing wound, ulcer, or bone fracture
Patients with a history of a serious non-healing wound, ulcer, or bone fracture are not eligible
Serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, active ulcer or bone fracture
Non-healing wound, ulcer or bone fracture
Serious, non-healing wound, ulcer, or bone fracture as so judged by the treating physician
Other clinically significant disorders such as:\r\n* Active infection requiring systemic treatment within  days before the first dose of study treatment\r\n* Serious non-healing wound/ulcer/bone fracture within  days before the first dose of study treatment
Non-healing wound, ulcer, or bone fracture
Patients with serious non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, ulcer, or bone fracture
Non-healing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or bone fracture
Ongoing serious, non-healing wound, ulcer, or bone fracture
Ongoing serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, skin ulcer, or bone fracture.
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
Participants who have non-healing wound, unhealed or incompletely healed fracture, or a compound (open) bone fracture at the time of enrollment
Serious non-healing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or bone fracture
Patients with a serious, non-healing wound, ulcer, or bone fracture are not eligible for participation
Non-healing wound, bone fracture or skin ulcer
No history of serious (i.e., requiring active medical therapy with medication or medical device under the supervision of a physician) non-healing wound, ulcer, trauma, or bone fracture within  days prior to study entry
Non-healing wound, ulcer or fracture
Serious or non-healing wound, ulcer or bone fracture
History of a non-healing wound, ulcer, or bone fracture within  days ( months) prior to registration
Non-healing wound, ulcer (including gastrointestinal), or fracture
Serious or non-healing wound, ulcer or bone fracture; if patient develops a serious or non-healing wound, ulcer or bone fracture after enrollment, but prior to study drug initiation, patient is not eligible to begin protocol therapy
Non-healing wound, ulcer or bone fracture
No serious non-healing wound, ulcer or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Serious or non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
History of serious or non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Non-healing wound, ulcer, or bone fracture
Patients with documented chronic non-healing wound, ulcer or bone fracture
Subject has a serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing active wound, ulcer, or bone fracture
Serious non-healing wound, active ulcer, or unhealed bone fracture.
Serious or non-healing wound, ulcer or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Non-healing wound, ulcer, or bone fracture.
Serious, non-healing wound, active ulcer, or untreated bone fracture
Patients with a serious non-healing wound ulcer, or bone fracture, or major surgical procedure within  days prior to starting treatment
Non-healing wound, ulcer, or bone fracture.
Have a serious or nonhealing wound, peptic ulcer, or bone fracture within  days prior to receiving study drugs.
Serious, non-healing wound, ulcer, or bone fracture.
Uncontrolled diabetes, active liver disease, poorly controlled chronic obstructive pulmonary disease, serious or non-healing wound, ulcer, or fracture;
Serious, non-healing wound, ulcer, or bone fracture
Severe, nonhealing or open wound, active ulcer, or untreated bone fracture
Serious and non-healing wound, active ulcer, or untreated bone fracture.
Non-healing wound, ulcer, or bone fracture
Non-healing wound, skin ulcer, or bone fracture
Serious or non-healing wound, active ulcer, or untreated bone fracture
Serious, non-healing wound, skin ulcer (of any grade), or bone fracture.
Serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing active wound, ulcer, or bone fracture
Ongoing serious non-healing wound, ulcer, or bone fracture
Non-healing wound, ulcer (including gastrointestinal), or fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture; bone fractures must be healed
Serious non-healing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or active bone fracture;
Serious or non-healing wound, ulcer, or bone fracture
Has had a serious nonhealing wound, ulcer, or bone fracture within  weeks prior to randomization
Serious nonhealing wound, ulcer, or bone fracture within  days prior to randomization
Serious non-healing wound, ulcer, or bone fracture
A serious, non-healing wound, ulcer, or bone fracture
Serious, non-healed wound, ulcer, or bone fracture
Any serious or non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or unhealed bone fracture
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
Patients with serious, non-healing wound, ulcer or bone fracture (other than pathologic fracture)
History of recent fracture (within  months of recruitment), complicated non-healing fracture, hip arthroplasty, knee arthroplasty
Patient must not have a serious or non-healing wound, ulcer, or bone fracture