Ongoing serious, non-healing wound, ulcer, or bone fracture History of serious or non-healing wound, ulcer, or bone fracture Serious or non-healing wound, skin ulcer, or bone fracture Prior osteoporotic fracture Serious nonhealing wound, ulcer, or bone fracture Serious non-healing wound, ulcer, or bone fracture within months prior to enrollment Serious, non-healing wound, active ulcer, or untreated bone fracture Serious, non-healing wound, ulcer, or bone fracture. Serious or non-healing wound, peptic ulcer, or bone fracture within days prior to initiation of study treatment; Patients with serious or non-healing wound, ulcer, or bone fracture Patients with a serious or nonhealing wound, ulcer, or bone fracture within days prior to enrollment Serious or non-healing wound, ulcer, or bone fracture. Any patient with a current non-healing wound, bone fracture, or skin ulcer is excluded Presence of serious or nonhealing wound, ulcer, or bone fracture within days prior to enrollment Serious, non-healing wound; active ulcer; or untreated bone fracture Patients with serious or non-healing wound, ulcer, or bone fracture. Patients who have non-healing wound, unhealed or incompletely healed fracture, or a compound (open) bone fracture at the time of enrollment are not eligible Ongoing serious, non-healing wound, ulcer, or bone fracture. Patients with a serious non-healing wound, active ulcer, or untreated bone fracture Any severe or poorly controlled systemic disease (e.g., hypertension; clinically significant cardiovascular, pulmonary, or metabolic disease, disorders of wound healing, ulcer or bone fracture) Serious, non-healing wound, ulcer, or bone fracture Serious, non-healing wound or ulcer; bone fracture within months prior to study entry Serious or non-healing wound, ulcer or bone fracture History or evidence of arterial thrombotic or hemorrhagic disorders within months before proposed start of treatment, non-healing wound, ulcer, or bone fracture Patients who have a non-healing wound, ulcer, or bone fracture. Serious non-healing wound, ulcer or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture. Non-healing wound, ulcer, non-healing traumatic bone fracture, or abscess within days of enrollment\r\n* Nondisplaced, uncomplicated pathologic fracture due to tumor may be eligible provided adequately treated with radiation, surgery or other treatments with full recovery based upon investigator assessment Serious, non-healing wound, ulcer, or bone fracture Serious, non-healing wound, ulcer, or bone fracture. Serious non-healing wound, ulcer or bone fracture Non-healing wound, ulcer, or bone fracture Patients who have serious, non-healing wound, ulcer, or bone fracture Serious, non-healing wound, ulcer, or bone fracture. have any non-healing wound, fracture, or ulcer within days prior to the planned start of study treatment; (Bevacizumab-related exclusion) History of abdominal fistula or gastrointestinal perforation within months prior to the first study treatment. Serious, non-healing wound, active ulcer, or untreated bone fracture (adjuvant trials: bone fractures must be healed) Serious or non-healing wound, ulcer, or bone fracture. Serious, non-healing wound, active ulcer, or untreated bone fracture, including tumor-related pathological fracture History of abdominal fistula or gastrointestinal perforation =< months before cycle , day ; serious non-healing wound, active ulcer, or untreated bone fracture (adjuvant trials: bone fractures must be healed) Non-healing wound, ulcer, or bone fracture Participant has a serious, non-healing wound, ulcer, or bone fracture Active wound, a serious or non-healing wound, an active ulcer or untreated bone fracture Non-healing wound, bone fracture, or skin ulcer mCRPC EXPANSION COHORT: Other clinically significant disorders such as:\r\n* Active infection requiring intravenous treatment within days of starting protocol treatment\r\n* Serious non-healing wound/ulcer/bone fracture (excluding stable compression fracture) within days before the first dose of study treatment The patient has a serious or nonhealing wound, ulcer, or bone fracture within days prior to enrollment Non-healing wound, ulcer, or bone fracture Non-healing wound, active peptic ulcer or bone fracture The patient has a serious or non-healing wound, ulcer, or bone fracture within days prior to enrollment Subject has a serious, non-healing wound, ulcer, or bone fracture Patients who have serious, non-healing wound, ulcer, or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture Serious non-healing wound, ulcer, or bone fracture Serious, non-healing wound, ulcer, or bone fracture Serious non-healing wound, active peptic ulcer, or untreated bone fracture Serious or non-healing wound, ulcer or bone fracture The patient has a serious or non-healing wound, ulcer, or bone fracture within days prior to first dose of protocol therapy Serious, non-healing wound, active ulcer, or untreated bone fracture A serious, non healing wound, ulcer, or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture; any bone fractures must be healed Serious, non-healing wound, ulcer, or bone fracture Non healing wound, ulcer or bone fracture Non-healing serious wound, ulcer, or bone fracture unrelated to the primary tumor Non?healing wound, ulcer, or bone fracture Presence of a serious nonhealing wound, ulcer, or bone fracture Ongoing significant, uncontrolled medical condition including: o Serious, non-healing wound, skin ulcer (of any grade), or bone fracture. History of serious or non-healing wound, ulcer, or bone fracture Patients with a non-healing wound, fracture, or ulcer Non-healing wound, ulcer or bone fracture Patients with serious non-healing wound, ulcer, or bone fracture within days before registration; patients should not have had any major surgical procedures within days of registration Serious, non-healing wound, active ulcer, or untreated bone fracture Subjects with a non-healing serious wound, ulcer, or bone fracture unrelated to the primary tumor Patients who have a serious or non-healing wound, ulcer, or bone fracture at the time of study enrollment are not eligible Serious or non-healing wound, ulcer or bone fracture Serious non-healing wound, ulcer, bone fracture, or abscess Serious, non-healing wound, ulcer, or bone fracture Patients with a serious or non-healing wound, ulcer, or bone fracture are not eligible for this study Serious, non-healing wound, ulcer, or bone fracture The participant has a serious nonhealing: (a) wound, (b) peptic ulcer, or (c) bone fracture. Serious, non-healing wound, infection, ulcer, bone fracture, or uncontrolled seizures Patients with a serious or nonhealing wound, ulcer, or bone fracture within days prior to enrollment Patient must not have serious or non-healing wound, ulcer, or bone fracture at the time of randomization Have had a serious or non-healing wound, ulcer, or bone fracture within days prior to enrollment. Serious non-healing wound, ulcer or bone fracture Patients with serous non-healing wound, ulcer, or bone fracture. Serious, non-healing wound, ulcer, or bone fracture requiring surgical intervention. Serious non-healing wound, ulcer, or bone fracture Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture Non-healing wound, ulcer or bone fracture Has history of a non-healing wound, ulcer, or bone fracture within days ( months) prior to entry in to the trial Serious non-healing wound, ulcer, or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture as judged by treating physician Serious, non-healing wound, ulcer, or bone fracture Patients with a history of a serious non-healing wound, ulcer, or bone fracture are not eligible Serious, non-healing wound, ulcer, or bone fracture Serious or non-healing wound, active ulcer or bone fracture Non-healing wound, ulcer or bone fracture Serious, non-healing wound, ulcer, or bone fracture as so judged by the treating physician Other clinically significant disorders such as:\r\n* Active infection requiring systemic treatment within days before the first dose of study treatment\r\n* Serious non-healing wound/ulcer/bone fracture within days before the first dose of study treatment Non-healing wound, ulcer, or bone fracture Patients with serious non-healing wound, ulcer, or bone fracture Serious or non-healing wound, ulcer, or bone fracture Non-healing wound, ulcer, or bone fracture Serious non-healing wound, ulcer, or bone fracture Ongoing serious, non-healing wound, ulcer, or bone fracture Ongoing serious, non-healing wound, ulcer, or bone fracture Serious or non-healing wound, skin ulcer, or bone fracture. Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture Participants who have non-healing wound, unhealed or incompletely healed fracture, or a compound (open) bone fracture at the time of enrollment Serious non-healing wound, ulcer, or bone fracture Serious non-healing wound, ulcer, or bone fracture Patients with a serious, non-healing wound, ulcer, or bone fracture are not eligible for participation Non-healing wound, bone fracture or skin ulcer No history of serious (i.e., requiring active medical therapy with medication or medical device under the supervision of a physician) non-healing wound, ulcer, trauma, or bone fracture within days prior to study entry Non-healing wound, ulcer or fracture Serious or non-healing wound, ulcer or bone fracture History of a non-healing wound, ulcer, or bone fracture within days ( months) prior to registration Non-healing wound, ulcer (including gastrointestinal), or fracture Serious or non-healing wound, ulcer or bone fracture; if patient develops a serious or non-healing wound, ulcer or bone fracture after enrollment, but prior to study drug initiation, patient is not eligible to begin protocol therapy Non-healing wound, ulcer or bone fracture No serious non-healing wound, ulcer or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture Serious or non-healing wound, ulcer, or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture History of serious or non-healing wound, ulcer, or bone fracture Serious, non-healing wound, active ulcer, or untreated bone fracture Non-healing wound, ulcer, or bone fracture Patients with documented chronic non-healing wound, ulcer or bone fracture Subject has a serious, non-healing wound, ulcer, or bone fracture Serious or non-healing active wound, ulcer, or bone fracture Serious non-healing wound, active ulcer, or unhealed bone fracture. Serious or non-healing wound, ulcer or bone fracture Serious, non-healing wound, ulcer, or bone fracture Serious, non-healing wound, ulcer, or bone fracture Non-healing wound, ulcer, or bone fracture. Serious, non-healing wound, active ulcer, or untreated bone fracture Patients with a serious non-healing wound ulcer, or bone fracture, or major surgical procedure within days prior to starting treatment Non-healing wound, ulcer, or bone fracture. Have a serious or nonhealing wound, peptic ulcer, or bone fracture within days prior to receiving study drugs. Serious, non-healing wound, ulcer, or bone fracture. Uncontrolled diabetes, active liver disease, poorly controlled chronic obstructive pulmonary disease, serious or non-healing wound, ulcer, or fracture; Serious, non-healing wound, ulcer, or bone fracture Severe, nonhealing or open wound, active ulcer, or untreated bone fracture Serious and non-healing wound, active ulcer, or untreated bone fracture. Non-healing wound, ulcer, or bone fracture Non-healing wound, skin ulcer, or bone fracture Serious or non-healing wound, active ulcer, or untreated bone fracture Serious, non-healing wound, skin ulcer (of any grade), or bone fracture. Serious, non-healing wound, ulcer, or bone fracture Serious or non-healing active wound, ulcer, or bone fracture Ongoing serious non-healing wound, ulcer, or bone fracture Non-healing wound, ulcer (including gastrointestinal), or fracture Serious, non-healing wound, active ulcer, or untreated bone fracture; bone fractures must be healed Serious non-healing wound, ulcer, or bone fracture Serious non-healing wound, ulcer, or active bone fracture; Serious or non-healing wound, ulcer, or bone fracture Has had a serious nonhealing wound, ulcer, or bone fracture within weeks prior to randomization Serious nonhealing wound, ulcer, or bone fracture within days prior to randomization Serious non-healing wound, ulcer, or bone fracture A serious, non-healing wound, ulcer, or bone fracture Serious, non-healed wound, ulcer, or bone fracture Any serious or non-healing wound, ulcer, or bone fracture Serious, non-healing wound, active ulcer, or unhealed bone fracture Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture Patients with serious, non-healing wound, ulcer or bone fracture (other than pathologic fracture) History of recent fracture (within months of recruitment), complicated non-healing fracture, hip arthroplasty, knee arthroplasty Patient must not have a serious or non-healing wound, ulcer, or bone fracture