ALT (SGPT) < x upper limit of normal (ULN) for age
ALT (SGPT) < x upper limit of normal (ULN) for age
AST (SGOT), ALT (SGPT) and Alkaline phosphatase . times upper limit of normal (if liver metastases are present, then x ULN is allowed)
PIKCA WILD TYPE COHORT (closed //): AST(SGOT)/ and ALT(SGPT) =< . X institutional upper limit normal
ENDOCRINE RESISTANT AND ADJUVANT COHORT: AST(SGOT)/ and ALT(SGPT) =< . X institutional upper limit normal
SGPT (ALT) =< x upper limit of normal (ULN) for age
AST (SGOT) and ALT (SGPT) ? . institutional upper limit of normal (ULN) [? ULN in presence of liver metastases]
AST (SGOT)/ALT (SGPT) ? X institutional upper limit of normal if with liver metastases; ?. X ULN if no liver metastases
INCLUSION CRITERIA FOR STRATUM C: ALT (SGPT) =< x institutional upper limit of normal
AST/SGOT and ALT/SGPT < . x the institutional upper limit of normal (IULN).
PART II: SGOT and SGPT =< x upper limit of normal (ULN)
AST (SGOT)/ALT(SGPT) (only if elevated liver function tests [LFTs] are due to disease) =< . x institutional upper limit of normal
PHASE II: AST (SGOT) =< . x institutional upper limit of normal
PHASE II: ALT (SGPT) =< . x institutional upper limit of normal
PHASE II SCLC: AST (SGOT)/ALT (SGPT) =< . X institutional upper limit of normal (=< X ULN if liver mets)
UROTHELIAL CARCINOMA EXPANSION COHORT: AST(SGOT)/ALT(SGPT) =< . X institutional upper limit of normal (=< X ULN if liver mets)
mCRPC EXPANSION COHORT: AST(SGOT)/ALT(SGPT) =< X institutional upper limit of normal (=< X ULN if liver mets)
Transaminases (AST/SGOT and ALT/SGPT) ? . times upper limit of normal
AST(SGOT)/ALT(SGPT) > . x institutional upper limit of normal
PHASE II STUDY COHORT TRIPLE NEGATIVE BREAST CANCER ELIGIBILITY CRITERIA (MEDI+O ONLY):\r\nAST(SGOT)/ALT(SGPT) =< . X institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< ULN
PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nAST(SGOT)/ALT(SGPT) =< . X institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< X ULN
Newly diagnosed MCL: AST (SGOT) and ALT (SGPT) < x upper limit of normal or < x upper limit of normal if hepatic metastases are present
Patients must have normal organ and marrow function as defined below: leukocytes > ,/mcL; absolute neutrophil count >,/mcL; platelets > ,/mcL, total bilirubin < or = . mg/dL. (Does NOT apply to patients with Gilbert's Syndrome); AST(SGOT)/ALT(SGPT) < . X institutional upper limit of normal (patients with liver involvement will be allowed < or = . X institutional upper normal limit) serum creatinine < . mg/dL
AST/SGOT and ALT/SGPT ?.ULN. (upper limit of normal)
SGOT (AST)<x upper limit of normal
Adequate hepatic function as documented by serum bilirubin< . mg/dl and SGOT and SGPT . or less x upper limit of normal.
ALT (SGPT): < . X institutional upper limit of normal
AST (SGOT)/ALT (SGPT) less than or equal to . x institutional upper limit of normal (ULN) or less than or equal to . x ULN in patients with liver metastases
SGPT (ALT) and SGOT (AST) < x upper limit of normal (for ALT, the upper limit of normal for all sites is defined as U/L)
TREATMENT: AST (SGOT)/ALT (SGPT) =< x institutional upper limit of normal
DOSE EXPANSION COHORT: AST(SGOT) ? . X institutional upper limit of normal (ULN)
Secondary Registration: AST (SGOT)/ALT (SGPT) =< . x institutional upper limit of normal
PHASE II: AST (SGOT)/ALT (SGPT) =< X institutional upper limit of normal (ULN) or =< X ULN if the patient has liver metastases
AST (SGOT), ALT (SGPT) ? . x upper limit of normal (ULN),
ALT (SGPT) and/or AST (SGOT) ? x upper limit of normal (ULN), or ? x ULN (if upon judgment of the treating physician, it is believed to be due to extramedullary hematopoiesis [EMH] related to MF);
AST/SGOT and ALT/SGPT ? x upper limit of normal (ULN) or ? . x ULN if liver tumor is present.
Adequate biochemistry laboratory results (AST/SGOT and ALT/SGPT ? . x upper limit of normal; bilirubin ? . mg/dL; creatinine clearance of ? mL/min).
PHASE II: AST (SGOT)/ALT (SGPT) =< . x institutional upper limit of normal
AST/SGOT and ALT/SGPT =< . x upper limit of normal (ULN) if liver metastases are present
SGOT(AST) and SGPT(ALT) < x ULN (upper limit of normal)
AST(SGOT)/ALT(SGPT) <. X institutional upper limit of normal
AST(SGOT)/ALT(SGPT) ? . X institutional upper limit of normal
AST(SGOT)/ALT(SGPT) ? . X institutional upper limit of normal
EXPANSION COHORT ONLY: AST (SGOT)/ALT (SGPT) =< . X institutional upper limit of normal
AST(SGOT)/ALT(SGPT) <. X institutional upper limit of normal
SGPT < X upper limit of normal.
AST, SGOT, ALT, SGPT ? . X upper limit of normal, < upper limit if there are liver metastases
Serum SGOT/AST or SGPT/ALT > . x upper limit of normal (ULN)
SGOT (AST) < x upper limit of normal.
AST/(SGOT)/ALT(SGPT) =< . x institutional upper limit of normal (ULN) (=< . x institutional ULN with documented liver metastases)
SGOT (AST) or SGPT (ALT) < . x upper limit of normal
AST/SGOT and ALT/SGPT ? x Upper Limit of Normal (ULN)
AST (SGOT)/ALT (SGPT) < . X institutional upper limit of normal
AST (SGOT)/ALT (SGPT) < . X institutional upper limit of normal
AST (SGOT)/ALT (SGPT) < . X institutional upper limit of normal