ALT (SGPT) < x upper limit of normal (ULN) for age ALT (SGPT) < x upper limit of normal (ULN) for age AST (SGOT), ALT (SGPT) and Alkaline phosphatase . times upper limit of normal (if liver metastases are present, then x ULN is allowed) PIKCA WILD TYPE COHORT (closed //): AST(SGOT)/ and ALT(SGPT) =< . X institutional upper limit normal ENDOCRINE RESISTANT AND ADJUVANT COHORT: AST(SGOT)/ and ALT(SGPT) =< . X institutional upper limit normal SGPT (ALT) =< x upper limit of normal (ULN) for age AST (SGOT) and ALT (SGPT) ? . institutional upper limit of normal (ULN) [? ULN in presence of liver metastases] AST (SGOT)/ALT (SGPT) ? X institutional upper limit of normal if with liver metastases; ?. X ULN if no liver metastases INCLUSION CRITERIA FOR STRATUM C: ALT (SGPT) =< x institutional upper limit of normal AST/SGOT and ALT/SGPT < . x the institutional upper limit of normal (IULN). PART II: SGOT and SGPT =< x upper limit of normal (ULN) AST (SGOT)/ALT(SGPT) (only if elevated liver function tests [LFTs] are due to disease) =< . x institutional upper limit of normal PHASE II: AST (SGOT) =< . x institutional upper limit of normal PHASE II: ALT (SGPT) =< . x institutional upper limit of normal PHASE II SCLC: AST (SGOT)/ALT (SGPT) =< . X institutional upper limit of normal (=< X ULN if liver mets) UROTHELIAL CARCINOMA EXPANSION COHORT: AST(SGOT)/ALT(SGPT) =< . X institutional upper limit of normal (=< X ULN if liver mets) mCRPC EXPANSION COHORT: AST(SGOT)/ALT(SGPT) =< X institutional upper limit of normal (=< X ULN if liver mets) Transaminases (AST/SGOT and ALT/SGPT) ? . times upper limit of normal AST(SGOT)/ALT(SGPT) > . x institutional upper limit of normal PHASE II STUDY COHORT TRIPLE NEGATIVE BREAST CANCER ELIGIBILITY CRITERIA (MEDI+O ONLY):\r\nAST(SGOT)/ALT(SGPT) =< . X institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< ULN PHASE II COLORECTAL CANCER COHORT (MEDI+C ONLY):\r\nAST(SGOT)/ALT(SGPT) =< . X institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< X ULN Newly diagnosed MCL: AST (SGOT) and ALT (SGPT) < x upper limit of normal or < x upper limit of normal if hepatic metastases are present Patients must have normal organ and marrow function as defined below: leukocytes > ,/mcL; absolute neutrophil count >,/mcL; platelets > ,/mcL, total bilirubin < or = . mg/dL. (Does NOT apply to patients with Gilbert's Syndrome); AST(SGOT)/ALT(SGPT) < . X institutional upper limit of normal (patients with liver involvement will be allowed < or = . X institutional upper normal limit) serum creatinine < . mg/dL AST/SGOT and ALT/SGPT ?.ULN. (upper limit of normal) SGOT (AST) . x upper limit of normal (ULN) SGOT (AST) < x upper limit of normal. AST/(SGOT)/ALT(SGPT) =< . x institutional upper limit of normal (ULN) (=< . x institutional ULN with documented liver metastases) SGOT (AST) or SGPT (ALT) < . x upper limit of normal AST/SGOT and ALT/SGPT ? x Upper Limit of Normal (ULN) AST (SGOT)/ALT (SGPT) < . X institutional upper limit of normal AST (SGOT)/ALT (SGPT) < . X institutional upper limit of normal AST (SGOT)/ALT (SGPT) < . X institutional upper limit of normal