--- a
+++ b/clusters/3009knumclusters/clust_36.txt
@@ -0,0 +1,299 @@
+Patients must not have any history of organ transplant that requires use of immunosuppressives
+Patients must not have organ allografts
+Patients with an immunodeficiency that existed prior to diagnosis such as primary immunodeficiency syndromes or organ transplant recipients are not eligible
+Patients who previously received a solid organ transplant
+History of organ allograft
+Patients with any history of solid organ or bone marrow transplant will not be eligible
+Has had an allogeneic tissue/solid organ transplant.
+History of allogenic bone marrow or solid organ transplant
+History of allogeneic organ transplant
+History of allogeneic bone marrow, stem-cell, or solid organ transplant
+Subjects with organ allograft requiring immunosuppression
+Subject with a history of organ transplant or allogeneic bone marrow transplant;
+Patient with an organ allograft
+Prior allogeneic bone marrow or solid organ transplant
+Previous HCT or solid organ transplant.
+History of organ allograft (including corneal transplant)
+No prior organ allograft
+Organ transplant recipients other than bone marrow transplant
+Prior solid organ transplant
+Patients scheduled for a combined transplant (such as liver-kidney), or having a previous solid organ, bone marrow, or autologous islet cell transplant.
+Receipt of an organ allograft.
+Has had an allogenic tissue/sold organ transplant.
+History of major organ transplant (i.e., heart, lungs, liver, or kidney).
+Prior solid organ or hematologic transplant.
+History of allogeneic organ transplant
+Organ transplant recipients
+Had a solid organ or allogeneic bone marrow transplant
+Has had an allogeneic tissue/solid organ transplant
+History of major solid organ transplant (i.e., heart, lungs, liver and kidney).
+History of allogeneic organ transplant
+EXCLUSION - PROCUREMENT: History of solid organ transplant
+EXCLUSION - INFUSION: History of solid organ transplant
+Subjects with clinically significant cardiovascular disease, history of organ transplant or allogeneic bone marrow transplant, active known or history of autoimmune disease that might recur or major surgery within 28 days prior to the first dose or still recovering from prior surgery.
+Prior solid organ transplant.
+History of allogeneic organ transplant
+Organ transplant
+Organ transplant that requires the use of immunosuppressive treatment.
+If a patient fully meets criteria for Arm 1, but has a history of solid organ or bone marrow transplant, the patient will be eligible for Arm 2
+History of prior solid organ or bone marrow transplant
+History of organ allograft including corneal transplant
+History of organ allograft (including corneal transplant)
+History of organ allograft (including corneal transplant)
+Patients with organ dysfunction
+Prior solid organ transplant
+Patients with organ allografts
+History of organ transplant
+Has a history of primary immunodeficiency or an allogeneic organ transplant
+History of organ transplantation (e.g. stem cell or solid organ transplant)
+History of organ transplant that requires use of immunosuppressives
+Solid organ or tissue transplant including stem cell transplant
+Prior allogeneic transplant of any solid organ or bone marrow/stem cells
+Organ transplant recipient
+Has undergone an organ transplant that requires use of immunosuppressive treatment
+History of primary immunodeficiency, history of allogeneic organ transplant that requires therapeutic immunosuppression
+Any solid organ transplant or bone marrow transplant
+Had a solid organ or hematologic transplant.
+History of organ transplant.
+Has had a prior solid organ transplant.
+Prior organ transplant requiring immunosuppressive therapy.
+Participants that have had bone marrow or solid organ transplant are excluded.
+History of allogeneic organ transplant
+Patients who have undergone a prior allogeneic hematopoietic or (other organ) transplant
+Has had an allogeneic tissue/solid organ transplant.
+Patients who have undergone a bone marrow or solid organ transplant
+History of allogeneic organ transplant
+Patients who have organ allografts.
+Had a solid organ or hematologic transplant
+History of allogeneic organ transplant
+Subjects who have had solid organ transplant
+Has a history of clinically severe autoimmune disease, or history of organ transplant
+Patients who have organ allografts
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+Prior organ allografts
+Any prior or planned organ transplant (e.g. liver transplant)
+History of allogeneic organ transplant.
+No history of organ allograft
+History of organ transplant
+Receipt of solid organ transplant
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+FOR ALL PHASES (Ib AND II): History of having received an allogeneic bone marrow or organ transplant
+History of allogeneic organ transplant
+History of allogeneic organ transplant (e.g. solid organ/bone marrow transplant patients)
+History of organ allograft (including corneal transplant)
+History of allogeneic tissue or solid organ transplant
+History of allogeneic organ transplant
+History of organ allograft (including corneal transplant) except stem cell transplants
+History of allogeneic organ transplant.
+History of organ allograft, stem cells or bone marrow transplant
+History of allogeneic tissue/solid organ transplant, prior stem cell or bone marrow transplant.
+Patients with a history of solid organ transplant
+History of allogeneic organ transplant
+Patients who have organ allografts
+History of allogeneic organ transplant
+History of organ transplant.
+History of organ allograft (including corneal transplant)
+Any history of organ allografts
+Has undergone an organ transplant that requires use of immunosuppressive treatment
+Presence of any tissue or organ allograft, regardless of need for immunosuppression, including corneal allograft; patients with a history of allogeneic hematopoietic stem cell transplant will also be excluded
+Patients with organ allografts (such as renal transplant) are excluded
+History of allogeneic organ transplant
+Had a solid organ or hematologic transplant
+Had a solid organ or hematologic transplant
+History of allogeneic organ transplant
+History of organ transplant that requires use of immunosuppressives
+Has had an allogeneic tissue/solid organ transplant
+History of allogeneic organ transplant
+Prior allogeneic solid organ transplant
+Currently receiving or ever received immunosuppressive therapy for an autoimmune disorder or an organ transplant
+Patients with organ allografts (such as renal transplant) are excluded
+Patient with history of prior solid organ or allogeneic bone marrow transplant
+History of allogeneic organ transplant or autoimmune disease
+Prior solid organ transplant
+History of allogeneic organ transplant
+Patients who have organ allografts
+Patients who have a history of an allogeneic tissue/solid organ transplant are not eligible
+Patients with previous solid organ transplant
+History of allogeneic organ transplant
+Malignancy attributed to prior solid organ transplant
+Prior organ transplant or autoimmune disease requiring immunosuppressive therapy
+History of allogeneic organ transplant
+Prior solid organ transplant requiring immunosuppressive therapy
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+REGORAFENIB EXCLUSION CRITERIA: History of organ allograft (including corneal transplant)
+History of allogeneic organ transplant
+History of organ transplant
+History of organ allograft (including corneal transplant).
+Has had an allogeneic tissue/solid organ transplant
+Prior organ transplant requiring immunosuppressive therapy
+Prior organ allograft
+Patients with organ allografts
+History of organ allograft including corneal transplant
+History of organ transplant.
+Subject has organ allografts
+Patients with organ allografts (such as renal transplant) are excluded
+Patients with organ allografts (such as renal transplant) are excluded
+Prior solid organ transplant
+History of solid organ or stem cell transplant requiring immunosuppressive medications
+Major anticipated illness or organ failure incompatible with survival form transplant
+History of organ transplant requiring therapeutic immunosuppression
+Patients who have organ allografts
+History of an allogeneic solid organ transplant or bone marrow transplant, or current active immunosuppressive therapy such as cyclosporine, tacrolimus, etc.
+Undergone an organ transplant that requires use of immunosuppressive treatment
+History of organ allograft (allogeneic bone marrow or stem cell transplant) within 4 months prior to first dose of study drug
+History of organ transplant that requires use of immunosuppressives
+History of solid organ transplant
+History of immunodeficiency, solid organ transplant, or tuberculosis
+Has a history of a bone marrow or solid organ transplant.
+Previous organ transplant
+Subjects with organ allografts.
+Has had an allogenic tissue/solid organ transplant
+History of allogenic organ transplantation (both solid organ and bone marrow)
+History of allogeneic organ transplant
+History of solid organ transplantation (with the exception of a corneal transplant > 3 months prior to screening)
+Prior organ transplant requiring immunosuppressive therapy
+History of allogeneic organ transplant.
+History of allogeneic organ transplant
+History of organ allograft or other history of immunodeficiency
+History of solid organ or stem cell transplant requiring immunosuppressive medications
+History of organ allograft (including corneal transplant)
+History of organ allograft including corneal transplant
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+Patients with history of organ transplant
+Multi-organ failure
+History of organ allograft (including corneal transplant)
+Solid organ transplant
+History of allogenic transplant
+History of allogenic transplant
+Subjects with organ allografts
+Has had a solid organ or hematologic transplant.
+Has had a prior solid organ transplant.
+Patients must not have any history of organ transplant that requires use of immunosuppressives
+Subject has a history of organ transplant or allogeneic bone marrow transplant;
+Has had a prior solid organ transplant.
+Patients within 60 days of allogenic bone transplant are not eligible; patients with solid organ transplant are not eligible
+History of organ allograft (including corneal transplant)
+Organ transplant recipients other than bone marrow transplant;
+Other immunocompromised status (e.g. organ transplant)
+Status post solid organ transplant.
+Patient has received an organ transplant
+Prior allogeneic bone marrow or solid organ transplant
+Had a solid organ or hematologic transplant
+History of allogeneic organ transplant
+Patients with history of organ transplant
+Has a transplanted organ or has undergone allogeneic bone marrow transplant
+History of organ allograft (including corneal transplant).
+Patients with organ allografts (such as renal transplant) are excluded
+Undergone a bone marrow or solid organ transplant.
+Allogenic tissue/solid organ transplant
+History of organ transplant
+History of allogeneic tissue/solid organ transplant
+Previous organ transplant
+History or evidence of melanoma associated with immunodeficiency states (eg, hereditary immune deficiency, organ transplant, or leukemia)
+Prior organ transplant requiring immunosuppressive therapy
+Subject has received an organ transplant
+Patients who have previously received a solid organ transplant are not eligible
+History of allogeneic bone marrow, stem cell, or solid organ transplant
+History of allogenic organ transplant.
+History of allogeneic organ transplant
+History of organ allograft (including corneal transplant)
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+Patients with an organ transplant, including those that have received an allogeneic bone marrow transplant.
+Subject has a history of organ allograft including liver transplant.
+Prior bone marrow transplant or history of organ transplant requiring the need for any chronic immunosuppressive medications
+Patients with organ allografts (such as renal transplant) are excluded
+History of organ transplant that requires use of immunosuppressive medications
+Subjects with organ allograft requiring immunosuppression
+History of allogeneic organ transplant
+History of organ allograft (including corneal transplant)
+History of major organ transplant.
+History of having received an allogeneic bone marrow or organ transplant
+History of organ allograft (including corneal transplant)
+Has had an allogeneic tissue/solid organ transplant
+Organ transplant (allograft) recipient
+Organ transplant (allograft) recipient
+Previous organ transplant
+Patients must not have an organ allograft or other history of immune compromise
+History of organ allograft (including corneal transplant)
+History of organ allograft (including corneal transplant)
+Subjects with organ allograft requiring immunosuppression
+History of an allogeneic solid organ transplant or bone marrow transplant, or current active immunosuppressive therapy such as cyclosporine, tacrolimus, etc.
+Presence of any tissue or organ allograft, regardless of need for immunosuppression, including corneal allograft; patients with a history of allogeneic hematopoeitic stem cell transplant will be excluded
+History of organ allograft. (Including corneal transplant)
+History of organ allograft (including corneal transplant)
+History of organ transplant.
+History of any organ or bone marrow transplant
+Subjects with organ allograft requiring immunosuppression
+History of organ allograft (including corneal transplant)
+History of organ transplant, or current active immunosuppressive therapy (such as cyclosporine, tacrolimus, etc.).
+History of organ transplant that requires use of immunosuppressives
+Subjects with organ allografts
+Prior solid organ transplant
+History of serious organ dysfunction or disease involving the heart, kidney, liver or other organ system that may place the patient at undue risk to undergo treatment
+History of organ allograft
+Subject has organ allografts
+History of organ allograft
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+History of allogeneic organ transplant
+Has a history of clinically severe autoimmune disease, or history of organ transplant
+Prior splenectomy or organ allograft
+History of allogeneic organ transplant
+Prior allogeneic SCT or organ transplant (Arms A and D only)
+Planned organ transplant during the study
+History of organ allograft (including corneal transplant).
+History of allogeneic organ transplant
+History of organ transplant.
+History of organ allograft (including corneal transplant)
+Serious organ dysfunction
+History of organ transplant that requires use of immunosuppressives
+History of organ allograft
+Patient with an organ allograft
+Prior organ transplant requiring immunosuppressive therapy
+History of solid organ transplantation (with the exception of a corneal transplant > 3 months prior to screening).
+Undergone a liver or other organ transplant
+Subjects who have received any type of solid organ transplant
+History of major organ transplant
+Patients who have undergone hematopoietic cell transplant (HCT), solid organ transplant (SOT)
+History of allogeneic organ transplant
+Patients with known HIV or with solid organ transplant
+History of solid organ transplant or bone marrow transplant
+Patients who have received organ transplant
+Organ transplant recipient
+History of organ allograft
+History of organ transplant
+Receiving an organ transplant during the same surgical procedure.
+Have a history of major organ transplant (for example: heart, lungs, liver, and kidney)
+History of organ allograft (including corneal transplant)
+History of major organ transplant
+History of organ allograft.
+History of having received allogeneic organ transplant
+History of allogeneic organ transplant
+History of organ transplant requiring therapeutic immunosuppression
+Patients with organ allografts (such as renal transplant) are excluded
+History of organ allograft (including corneal transplant)
+Has had previous allogeneic tissue/solid organ transplant
+Patients must not have organ allografts
+History of allogenic organ transplant
+Subjects with a previous solid organ transplant
+History (hx) of organ transplant
+History of allogeneic bone marrow, stem cell, or solid organ transplant
+Organ Transplant: Patients may NOT be the recipients of an organ transplant.
+Organ transplant (allograft) recipient
+Patients must have a pre-transplant multi-organ assessment with the following outcome:
+GENERAL EXCLUSION CRITERIA FOR SUBPROTOCOLS: Patients who have had a prior solid organ transplant are not eligible
+Prior allotransplant, including allogeneic hematopoietic cell transplant or solid organ allogeneic transplant
+Prior organ transplant
+Received solid organ transplant (kidney or other)
+Single solid organ recipient (kidney only)
+Prior solid organ or bone marrow transplant
+Subjects who have received any type of solid organ transplant
+History of allogeneic organ transplant
+Prior organ transplant