Patients must not have any history of organ transplant that requires use of immunosuppressives
Patients must not have organ allografts
Patients with an immunodeficiency that existed prior to diagnosis such as primary immunodeficiency syndromes or organ transplant recipients are not eligible
Patients who previously received a solid organ transplant
History of organ allograft
Patients with any history of solid organ or bone marrow transplant will not be eligible
Has had an allogeneic tissue/solid organ transplant.
History of allogenic bone marrow or solid organ transplant
History of allogeneic organ transplant
History of allogeneic bone marrow, stem-cell, or solid organ transplant
Subjects with organ allograft requiring immunosuppression
Subject with a history of organ transplant or allogeneic bone marrow transplant;
Patient with an organ allograft
Prior allogeneic bone marrow or solid organ transplant
Previous HCT or solid organ transplant.
History of organ allograft (including corneal transplant)
No prior organ allograft
Organ transplant recipients other than bone marrow transplant
Prior solid organ transplant
Patients scheduled for a combined transplant (such as liver-kidney), or having a previous solid organ, bone marrow, or autologous islet cell transplant.
Receipt of an organ allograft.
Has had an allogenic tissue/sold organ transplant.
History of major organ transplant (i.e., heart, lungs, liver, or kidney).
Prior solid organ or hematologic transplant.
History of allogeneic organ transplant
Organ transplant recipients
Had a solid organ or allogeneic bone marrow transplant
Has had an allogeneic tissue/solid organ transplant
History of major solid organ transplant (i.e., heart, lungs, liver and kidney).
History of allogeneic organ transplant
EXCLUSION - PROCUREMENT: History of solid organ transplant
EXCLUSION - INFUSION: History of solid organ transplant
Subjects with clinically significant cardiovascular disease, history of organ transplant or allogeneic bone marrow transplant, active known or history of autoimmune disease that might recur or major surgery within 28 days prior to the first dose or still recovering from prior surgery.
Prior solid organ transplant.
History of allogeneic organ transplant
Organ transplant
Organ transplant that requires the use of immunosuppressive treatment.
If a patient fully meets criteria for Arm 1, but has a history of solid organ or bone marrow transplant, the patient will be eligible for Arm 2
History of prior solid organ or bone marrow transplant
History of organ allograft including corneal transplant
History of organ allograft (including corneal transplant)
History of organ allograft (including corneal transplant)
Patients with organ dysfunction
Prior solid organ transplant
Patients with organ allografts
History of organ transplant
Has a history of primary immunodeficiency or an allogeneic organ transplant
History of organ transplantation (e.g. stem cell or solid organ transplant)
History of organ transplant that requires use of immunosuppressives
Solid organ or tissue transplant including stem cell transplant
Prior allogeneic transplant of any solid organ or bone marrow/stem cells
Organ transplant recipient
Has undergone an organ transplant that requires use of immunosuppressive treatment
History of primary immunodeficiency, history of allogeneic organ transplant that requires therapeutic immunosuppression
Any solid organ transplant or bone marrow transplant
Had a solid organ or hematologic transplant.
History of organ transplant.
Has had a prior solid organ transplant.
Prior organ transplant requiring immunosuppressive therapy.
Participants that have had bone marrow or solid organ transplant are excluded.
History of allogeneic organ transplant
Patients who have undergone a prior allogeneic hematopoietic or (other organ) transplant
Has had an allogeneic tissue/solid organ transplant.
Patients who have undergone a bone marrow or solid organ transplant
History of allogeneic organ transplant
Patients who have organ allografts.
Had a solid organ or hematologic transplant
History of allogeneic organ transplant
Subjects who have had solid organ transplant
Has a history of clinically severe autoimmune disease, or history of organ transplant
Patients who have organ allografts
History of allogeneic organ transplant
History of allogeneic organ transplant
Prior organ allografts
Any prior or planned organ transplant (e.g. liver transplant)
History of allogeneic organ transplant.
No history of organ allograft
History of organ transplant
Receipt of solid organ transplant
History of allogeneic organ transplant
History of allogeneic organ transplant
History of allogeneic organ transplant
FOR ALL PHASES (Ib AND II): History of having received an allogeneic bone marrow or organ transplant
History of allogeneic organ transplant
History of allogeneic organ transplant (e.g. solid organ/bone marrow transplant patients)
History of organ allograft (including corneal transplant)
History of allogeneic tissue or solid organ transplant
History of allogeneic organ transplant
History of organ allograft (including corneal transplant) except stem cell transplants
History of allogeneic organ transplant.
History of organ allograft, stem cells or bone marrow transplant
History of allogeneic tissue/solid organ transplant, prior stem cell or bone marrow transplant.
Patients with a history of solid organ transplant
History of allogeneic organ transplant
Patients who have organ allografts
History of allogeneic organ transplant
History of organ transplant.
History of organ allograft (including corneal transplant)
Any history of organ allografts
Has undergone an organ transplant that requires use of immunosuppressive treatment
Presence of any tissue or organ allograft, regardless of need for immunosuppression, including corneal allograft; patients with a history of allogeneic hematopoietic stem cell transplant will also be excluded
Patients with organ allografts (such as renal transplant) are excluded
History of allogeneic organ transplant
Had a solid organ or hematologic transplant
Had a solid organ or hematologic transplant
History of allogeneic organ transplant
History of organ transplant that requires use of immunosuppressives
Has had an allogeneic tissue/solid organ transplant
History of allogeneic organ transplant
Prior allogeneic solid organ transplant
Currently receiving or ever received immunosuppressive therapy for an autoimmune disorder or an organ transplant
Patients with organ allografts (such as renal transplant) are excluded
Patient with history of prior solid organ or allogeneic bone marrow transplant
History of allogeneic organ transplant or autoimmune disease
Prior solid organ transplant
History of allogeneic organ transplant
Patients who have organ allografts
Patients who have a history of an allogeneic tissue/solid organ transplant are not eligible
Patients with previous solid organ transplant
History of allogeneic organ transplant
Malignancy attributed to prior solid organ transplant
Prior organ transplant or autoimmune disease requiring immunosuppressive therapy
History of allogeneic organ transplant
Prior solid organ transplant requiring immunosuppressive therapy
History of allogeneic organ transplant
History of allogeneic organ transplant
REGORAFENIB EXCLUSION CRITERIA: History of organ allograft (including corneal transplant)
History of allogeneic organ transplant
History of organ transplant
History of organ allograft (including corneal transplant).
Has had an allogeneic tissue/solid organ transplant
Prior organ transplant requiring immunosuppressive therapy
Prior organ allograft
Patients with organ allografts
History of organ allograft including corneal transplant
History of organ transplant.
Subject has organ allografts
Patients with organ allografts (such as renal transplant) are excluded
Patients with organ allografts (such as renal transplant) are excluded
Prior solid organ transplant
History of solid organ or stem cell transplant requiring immunosuppressive medications
Major anticipated illness or organ failure incompatible with survival form transplant
History of organ transplant requiring therapeutic immunosuppression
Patients who have organ allografts
History of an allogeneic solid organ transplant or bone marrow transplant, or current active immunosuppressive therapy such as cyclosporine, tacrolimus, etc.
Undergone an organ transplant that requires use of immunosuppressive treatment
History of organ allograft (allogeneic bone marrow or stem cell transplant) within 4 months prior to first dose of study drug
History of organ transplant that requires use of immunosuppressives
History of solid organ transplant
History of immunodeficiency, solid organ transplant, or tuberculosis
Has a history of a bone marrow or solid organ transplant.
Previous organ transplant
Subjects with organ allografts.
Has had an allogenic tissue/solid organ transplant
History of allogenic organ transplantation (both solid organ and bone marrow)
History of allogeneic organ transplant
History of solid organ transplantation (with the exception of a corneal transplant > 3 months prior to screening)
Prior organ transplant requiring immunosuppressive therapy
History of allogeneic organ transplant.
History of allogeneic organ transplant
History of organ allograft or other history of immunodeficiency
History of solid organ or stem cell transplant requiring immunosuppressive medications
History of organ allograft (including corneal transplant)
History of organ allograft including corneal transplant
History of allogeneic organ transplant
History of allogeneic organ transplant
Patients with history of organ transplant
Multi-organ failure
History of organ allograft (including corneal transplant)
Solid organ transplant
History of allogenic transplant
History of allogenic transplant
Subjects with organ allografts
Has had a solid organ or hematologic transplant.
Has had a prior solid organ transplant.
Patients must not have any history of organ transplant that requires use of immunosuppressives
Subject has a history of organ transplant or allogeneic bone marrow transplant;
Has had a prior solid organ transplant.
Patients within 60 days of allogenic bone transplant are not eligible; patients with solid organ transplant are not eligible
History of organ allograft (including corneal transplant)
Organ transplant recipients other than bone marrow transplant;
Other immunocompromised status (e.g. organ transplant)
Status post solid organ transplant.
Patient has received an organ transplant
Prior allogeneic bone marrow or solid organ transplant
Had a solid organ or hematologic transplant
History of allogeneic organ transplant
Patients with history of organ transplant
Has a transplanted organ or has undergone allogeneic bone marrow transplant
History of organ allograft (including corneal transplant).
Patients with organ allografts (such as renal transplant) are excluded
Undergone a bone marrow or solid organ transplant.
Allogenic tissue/solid organ transplant
History of organ transplant
History of allogeneic tissue/solid organ transplant
Previous organ transplant
History or evidence of melanoma associated with immunodeficiency states (eg, hereditary immune deficiency, organ transplant, or leukemia)
Prior organ transplant requiring immunosuppressive therapy
Subject has received an organ transplant
Patients who have previously received a solid organ transplant are not eligible
History of allogeneic bone marrow, stem cell, or solid organ transplant
History of allogenic organ transplant.
History of allogeneic organ transplant
History of organ allograft (including corneal transplant)
History of allogeneic organ transplant
History of allogeneic organ transplant
History of allogeneic organ transplant
Patients with an organ transplant, including those that have received an allogeneic bone marrow transplant.
Subject has a history of organ allograft including liver transplant.
Prior bone marrow transplant or history of organ transplant requiring the need for any chronic immunosuppressive medications
Patients with organ allografts (such as renal transplant) are excluded
History of organ transplant that requires use of immunosuppressive medications
Subjects with organ allograft requiring immunosuppression
History of allogeneic organ transplant
History of organ allograft (including corneal transplant)
History of major organ transplant.
History of having received an allogeneic bone marrow or organ transplant
History of organ allograft (including corneal transplant)
Has had an allogeneic tissue/solid organ transplant
Organ transplant (allograft) recipient
Organ transplant (allograft) recipient
Previous organ transplant
Patients must not have an organ allograft or other history of immune compromise
History of organ allograft (including corneal transplant)
History of organ allograft (including corneal transplant)
Subjects with organ allograft requiring immunosuppression
History of an allogeneic solid organ transplant or bone marrow transplant, or current active immunosuppressive therapy such as cyclosporine, tacrolimus, etc.
Presence of any tissue or organ allograft, regardless of need for immunosuppression, including corneal allograft; patients with a history of allogeneic hematopoeitic stem cell transplant will be excluded
History of organ allograft. (Including corneal transplant)
History of organ allograft (including corneal transplant)
History of organ transplant.
History of any organ or bone marrow transplant
Subjects with organ allograft requiring immunosuppression
History of organ allograft (including corneal transplant)
History of organ transplant, or current active immunosuppressive therapy (such as cyclosporine, tacrolimus, etc.).
History of organ transplant that requires use of immunosuppressives
Subjects with organ allografts
Prior solid organ transplant
History of serious organ dysfunction or disease involving the heart, kidney, liver or other organ system that may place the patient at undue risk to undergo treatment
History of organ allograft
Subject has organ allografts
History of organ allograft
History of allogeneic organ transplant
History of allogeneic organ transplant
History of allogeneic organ transplant
Has a history of clinically severe autoimmune disease, or history of organ transplant
Prior splenectomy or organ allograft
History of allogeneic organ transplant
Prior allogeneic SCT or organ transplant (Arms A and D only)
Planned organ transplant during the study
History of organ allograft (including corneal transplant).
History of allogeneic organ transplant
History of organ transplant.
History of organ allograft (including corneal transplant)
Serious organ dysfunction
History of organ transplant that requires use of immunosuppressives
History of organ allograft
Patient with an organ allograft
Prior organ transplant requiring immunosuppressive therapy
History of solid organ transplantation (with the exception of a corneal transplant > 3 months prior to screening).
Undergone a liver or other organ transplant
Subjects who have received any type of solid organ transplant
History of major organ transplant
Patients who have undergone hematopoietic cell transplant (HCT), solid organ transplant (SOT)
History of allogeneic organ transplant
Patients with known HIV or with solid organ transplant
History of solid organ transplant or bone marrow transplant
Patients who have received organ transplant
Organ transplant recipient
History of organ allograft
History of organ transplant
Receiving an organ transplant during the same surgical procedure.
Have a history of major organ transplant (for example: heart, lungs, liver, and kidney)
History of organ allograft (including corneal transplant)
History of major organ transplant
History of organ allograft.
History of having received allogeneic organ transplant
History of allogeneic organ transplant
History of organ transplant requiring therapeutic immunosuppression
Patients with organ allografts (such as renal transplant) are excluded
History of organ allograft (including corneal transplant)
Has had previous allogeneic tissue/solid organ transplant
Patients must not have organ allografts
History of allogenic organ transplant
Subjects with a previous solid organ transplant
History (hx) of organ transplant
History of allogeneic bone marrow, stem cell, or solid organ transplant
Organ Transplant: Patients may NOT be the recipients of an organ transplant.
Organ transplant (allograft) recipient
Patients must have a pre-transplant multi-organ assessment with the following outcome:
GENERAL EXCLUSION CRITERIA FOR SUBPROTOCOLS: Patients who have had a prior solid organ transplant are not eligible
Prior allotransplant, including allogeneic hematopoietic cell transplant or solid organ allogeneic transplant
Prior organ transplant
Received solid organ transplant (kidney or other)
Single solid organ recipient (kidney only)
Prior solid organ or bone marrow transplant
Subjects who have received any type of solid organ transplant
History of allogeneic organ transplant
Prior organ transplant