| 1 |
33452442 |
10.1038/s41380-020-01003-y |
2022 |
Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. |
GRB2 |
| 2 |
34429382 |
10.1126/scisignal.abe2606 |
2022 |
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function. |
GRB2 |
| 3 |
34589930 |
10.1016/j.jtocrr.2020.100023 |
2022 |
Oncogenic Fusions May Be Frequently Present at Resistance of EGFR Tyrosine Kinase Inhibitors in Patients With NSCLC: A Brief Report. |
GRB2 |
| 4 |
35574218 |
10.18632/oncotarget.28228 |
2022 |
Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation. |
GRB2 |
| 5 |
35895897 |
10.1182/blood.2022016424 |
2022 |
Gab2-MALT1 Axis Regulates Thromboinflammation and Deep Vein Thrombosis. |
GRB2 |
| 6 |
36037968 |
10.1016/j.jbc.2022.102419 |
2022 |
Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin. |
GRB2 |
| 7 |
33532178 |
10.1016/j.apsb.2020.07.010 |
2021 |
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies. |
GRB2 |
| 8 |
33619116 |
10.1158/0008-5472.CAN-20-2297 |
2021 |
NPM-ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation. |
GRB2 |
| 9 |
33627783 |
10.1038/s41388-021-01684-x |
2021 |
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. |
GRB2 |
| 10 |
33848463 |
10.1016/j.cell.2021.03.031 |
2021 |
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. |
GRB2 |
| 11 |
34409981 |
10.1042/BCJ20210175 |
2021 |
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes. |
GRB2 |
| 12 |
29556564 |
10.1016/j.bbrep.2018.01.007 |
2020 |
The role of the ShcD and RET interaction in neuroblastoma survival and migration. |
GRB2 |
| 13 |
31151983 |
10.1182/blood.2019001043 |
2020 |
A novel model of controlling PD-L1 expression in ALK<sup>+</sup> anaplastic large cell lymphoma revealed by CRISPR screening. |
GRB2 |
| 14 |
31362927 |
10.1182/bloodadvances.2018016162 |
2020 |
Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling. |
GRB2 |
| 15 |
31789417 |
10.3892/ijmm.2019.4414 |
2020 |
Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats. |
GRB2 |
| 16 |
30024968 |
10.1371/journal.ppat.1007111 |
2019 |
Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB. |
GRB2 |
| 17 |
27472394 |
10.18632/oncotarget.10861 |
2018 |
c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus. |
GRB2 |
| 18 |
26719098 |
10.1038/leu.2015.357 |
2017 |
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. |
GRB2 |
| 19 |
26757737 |
10.1007/s00401-016-1536-2 |
2017 |
Genomic characterization of primary central nervous system lymphoma. |
GRB2 |
| 20 |
28046066 |
10.1371/journal.ppat.1006120 |
2017 |
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. |
GRB2 |
| 21 |
26773044 |
10.1182/blood-2015-06-653006 |
2016 |
Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. |
GRB2 |
| 22 |
26781991 |
10.1158/0008-5472.CAN-15-1512 |
2016 |
NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells. |
GRB2 |
| 23 |
25080849 |
10.1111/ejh.12427 |
2015 |
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. |
GRB2 |
| 24 |
25575524 |
10.4077/CJP.2014.BAD281 |
2015 |
Effects of RING-SH2Grb², a chimeric protein containing the E3 ligase domain of Cbl, on the EGFR pathway. |
GRB2 |
| 25 |
24104394 |
10.1038/leu.2013.291 |
2014 |
MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma. |
GRB2 |
| 26 |
24297922 |
10.1073/pnas.1319665110 |
2014 |
Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. |
GRB2 |
| 27 |
22987556 |
10.1002/bmb.20643 |
2013 |
Problem-solving test: signal transduction in Philadelphia chromosome positive leukemia cells. |
GRB2 |
| 28 |
21189087 |
10.1902/jop.2010.100312 |
2012 |
Real-time quantitative polymerase chain reaction analysis of patients with refractory chronic periodontitis. |
GRB2 |
| 29 |
22261070 |
10.1016/j.bpj.2011.09.058 |
2012 |
Analyzing the homeostasis of signaling proteins by a combination of Western blot and fluorescence correlation spectroscopy. |
GRB2 |
| 30 |
21596750 |
10.1074/jbc.M110.197525 |
2011 |
The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination. |
GRB2 |
| 31 |
19815557 |
10.1074/jbc.M109.072660 |
2010 |
Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. |
GRB2 |
| 32 |
20554525 |
10.1074/jbc.M110.116327 |
2010 |
Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth. |
GRB2 |
| 33 |
20697568 |
|
2010 |
Tnk1/Kos1: a novel tumor suppressor. |
GRB2 |
| 34 |
18829987 |
10.1093/intimm/dxn108 |
2009 |
CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis. |
GRB2 |
| 35 |
19285946 |
10.1016/j.molcel.2009.02.012 |
2009 |
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. |
GRB2 |
| 36 |
19716163 |
10.1016/j.humpath.2009.05.009 |
2009 |
Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas. |
GRB2 |
| 37 |
18059481 |
10.1038/sj.leu.2405057 |
2008 |
Subcellular distribution of p210(BCR-ABL) in CML cell lines and primary CD34+ CML cells. |
GRB2 |
| 38 |
18483552 |
10.1371/journal.ppat.1000064 |
2008 |
A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor. |
GRB2 |
| 39 |
17312329 |
10.1200/JCO.2006.09.3534 |
2007 |
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias. |
GRB2 |
| 40 |
17341634 |
10.1196/annals.1378.086 |
2007 |
Design and functional activity of phosphopeptides with potential immunomodulating capacity, based on the sequence of Grb2-associated binder 1. |
GRB2 |
| 41 |
17384277 |
10.1196/annals.1378.036 |
2007 |
Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells. |
GRB2 |
| 42 |
17483340 |
10.1158/0008-5472.CAN-06-4350 |
2007 |
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. |
GRB2 |
| 43 |
17489982 |
10.1111/j.1365-2141.2007.06597.x |
2007 |
Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein. |
GRB2 |
| 44 |
16105984 |
10.1182/blood-2005-03-1204 |
2006 |
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. |
GRB2 |
| 45 |
17075693 |
10.1007/s00018-006-6346-6 |
2006 |
Optimization of the cellular import of functionally active SH2-domain-interacting phosphopeptides. |
GRB2 |
| 46 |
15735675 |
10.1038/sj.onc.1208523 |
2005 |
Domain-specific function of ShcC docking protein in neuroblastoma cells. |
GRB2 |
| 47 |
14530346 |
10.4049/jimmunol.171.8.4227 |
2004 |
Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells. |
GRB2 |
| 48 |
14551136 |
10.1182/blood-2003-07-2617 |
2004 |
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling. |
GRB2 |
| 49 |
14963047 |
10.1074/jbc.M309234200 |
2004 |
Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251. |
GRB2 |
| 50 |
14968112 |
10.1038/sj.onc.1207398 |
2004 |
Identification of NPM-ALK interacting proteins by tandem mass spectrometry. |
GRB2 |
| 51 |
15050920 |
10.1016/s1535-6108(04)00053-4 |
2004 |
Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. |
GRB2 |
| 52 |
12531430 |
10.1016/s0898-6568(02)00122-5 |
2003 |
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2. |
GRB2 |
| 53 |
12688310 |
10.1080/1042819021000037930 |
2003 |
High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia. |
GRB2 |
| 54 |
11888936 |
|
2002 |
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin. |
GRB2 |
| 55 |
11919185 |
10.1074/jbc.M111145200 |
2002 |
A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells. |
GRB2 |
| 56 |
11929787 |
10.1182/blood.v99.8.2957 |
2002 |
The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. |
GRB2 |
| 57 |
11943732 |
10.1016/S0002-9440(10)62574-6 |
2002 |
Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. |
GRB2 |
| 58 |
12372784 |
10.1152/ajprenal.00380.2001 |
2002 |
Sustained activation of MAPK/ERKs signaling pathway in cystic kidneys from bcl-2 -/- mice. |
GRB2 |
| 59 |
11207269 |
10.4049/jimmunol.166.5.3167 |
2001 |
Activation of the EBV/C3d receptor (CR2, CD21) on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with phosphatidylinositol 3 kinase. |
GRB2 |
| 60 |
10706082 |
|
2000 |
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma. |
GRB2 |
| 61 |
10747947 |
10.1074/jbc.M000689200 |
2000 |
Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. |
GRB2 |
| 62 |
10752981 |
10.3109/10428190009089430 |
2000 |
Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. |
GRB2 |
| 63 |
10838162 |
10.1016/s0167-4889(00)00035-5 |
2000 |
Prolactin stimulation of tyrosyl phosphorylation of Shc proteins in Nb(2) lymphoma cells, but not mammary tissues. |
GRB2 |
| 64 |
10982827 |
10.1128/MCB.20.19.7109-7120.2000 |
2000 |
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. |
GRB2 |
| 65 |
11034601 |
10.1084/jem.192.8.1115 |
2000 |
Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans. |
GRB2 |
| 66 |
9794256 |
10.1016/s0898-6568(97)00195-2 |
1999 |
Serum and insulin induce a Grb2-dependent shift in agonist affinity of beta-adrenergic receptors. |
GRB2 |
| 67 |
9416834 |
10.1038/sj.onc.1201468 |
1998 |
Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. |
GRB2 |
| 68 |
9695962 |
10.1046/j.1365-2141.1998.00803.x |
1998 |
Haemopoietic transformation by the TEL/ABL oncogene. |
GRB2 |
| 69 |
9819383 |
10.1128/MCB.18.12.6951 |
1998 |
Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. |
GRB2 |
| 70 |
9845379 |
|
1998 |
c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells. |
GRB2 |
| 71 |
9040011 |
10.1093/intimm/9.2.291 |
1997 |
Targets of p56(lck) activity in immature thymoblasts: stimulation of the Ras/Raf/MAPK pathway. |
GRB2 |
| 72 |
9126968 |
|
1997 |
Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. |
GRB2 |
| 73 |
9233773 |
10.1038/sj.onc.1201163 |
1997 |
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. |
GRB2 |
| 74 |
9259313 |
10.1210/mend.11.9.9980 |
1997 |
Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. |
GRB2 |
| 75 |
9341187 |
10.1074/jbc.272.43.27362 |
1997 |
Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation. |
GRB2 |
| 76 |
8632004 |
10.1074/jbc.271.7.3856 |
1996 |
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells. |
GRB2 |
| 77 |
8633037 |
10.1073/pnas.93.9.4181 |
1996 |
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). |
GRB2 |
| 78 |
8710377 |
|
1996 |
Formation of Shc/Grb2- and Crk adaptor complexes containing tyrosine phosphorylated Cbl upon stimulation of the B-cell antigen receptor. |
GRB2 |
| 79 |
8770364 |
10.1111/j.1445-5994.1995.tb02892.x |
1996 |
The cbl oncogene: a novel substrate of protein tyrosine kinases. |
GRB2 |
| 80 |
8892607 |
|
1996 |
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. |
GRB2 |
| 81 |
7553858 |
10.1016/0092-8674(95)90277-5 |
1995 |
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. |
GRB2 |
| 82 |
7628388 |
10.1210/endo.136.8.7628388 |
1995 |
Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless. |
GRB2 |
| 83 |
7717978 |
10.1042/bj3070215 |
1995 |
The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line. |
GRB2 |
Datasets
Models
