| 1 |
30305939 |
10.1136/esmoopen-2018-000387 |
2022 |
BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance. |
ATR |
| 2 |
34679598 |
10.3390/diagnostics11101902 |
2022 |
A Multi-mRNA Prognostic Signature for Anti-TNFα Therapy Response in Patients with Inflammatory Bowel Disease. |
ATR |
| 3 |
34791862 |
10.33594/000000471 |
2022 |
Atrazine Inhalation Worsen Pulmonary Fibrosis Regulating the Nuclear Factor-Erythroid 2-Related Factor (Nrf2) Pathways Inducing Brain Comorbidities. |
ATR |
| 4 |
34886743 |
10.1080/15257770.2021.2013500 |
2022 |
Fludarabine nucleoside induces major changes in the p53 interactome in human B-lymphoid cancer cell lines. |
ATR |
| 5 |
35439335 |
10.1002/hon.3007 |
2022 |
The potential efficacy and mechanism of bendamustine in entra-nodal NK/T cell lymphoma. |
ATR |
| 6 |
35510955 |
10.15252/emmm.202215816 |
2022 |
A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability. |
ATR |
| 7 |
35589932 |
10.1038/s41598-022-12426-8 |
2022 |
Long-term outcomes of cataract surgery with toric intraocular lens implantation by the type of preoperative astigmatism. |
ATR |
| 8 |
31885322 |
10.1080/15384101.2019.1706903 |
2021 |
The double dealing of cyclin D1. |
ATR |
| 9 |
32321318 |
10.1080/13543784.2020.1760245 |
2021 |
Novel agents for mantle cell lymphoma: molecular rational and clinical data. |
ATR |
| 10 |
32504211 |
10.1007/s10689-020-00192-3 |
2021 |
Germline variants discovered in lymphoma patients undergoing tumor profiling: a case series. |
ATR |
| 11 |
32517809 |
10.1186/s13046-020-01597-9 |
2021 |
A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe. |
ATR |
| 12 |
32571801 |
10.26508/lsa.202000671 |
2021 |
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells. |
ATR |
| 13 |
32601814 |
10.1007/s11864-020-00763-7 |
2021 |
Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma. |
ATR |
| 14 |
32653773 |
10.1016/j.ejca.2020.05.010 |
2021 |
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma. |
ATR |
| 15 |
33257682 |
10.1038/s41419-020-03231-0 |
2021 |
ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells. |
ATR |
| 16 |
33414171 |
10.1158/0008-5472.CAN-20-1504 |
2021 |
CDK2-Mediated Upregulation of TNFα as a Mechanism of Selective Cytotoxicity in Acute Leukemia. |
ATR |
| 17 |
33641489 |
10.1177/0300060521993315 |
2021 |
Atractylenolide I alleviates ischemia/reperfusion injury by preserving mitochondrial function and inhibiting caspase-3 activity. |
ATR |
| 18 |
34348985 |
10.1136/jclinpath-2021-207441 |
2021 |
Clinicopathological characteristics and genetic variations of uterine tumours resembling ovarian sex cord tumours. |
ATR |
| 19 |
34521752 |
10.1073/pnas.2105440118 |
2021 |
DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice. |
ATR |
| 20 |
34819497 |
10.1038/s41467-021-27057-2 |
2021 |
ATR inhibition enables complete tumour regression in ALK-driven NB mouse models. |
ATR |
| 21 |
28693235 |
10.3892/ol.2017.6219 |
2020 |
Japanese apricot extract (MK615) potentiates bendamustine-induced apoptosis via impairment of the DNA damage response in lymphoma cells. |
ATR |
| 22 |
30787154 |
10.1128/JVI.02290-18 |
2020 |
Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3. |
ATR |
| 23 |
30935402 |
10.1186/s13045-019-0716-7 |
2020 |
Molecular pathogenic pathways in extranodal NK/T cell lymphoma. |
ATR |
| 24 |
31056398 |
10.1016/j.ccell.2019.03.014 |
2020 |
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. |
ATR |
| 25 |
31064869 |
10.1158/1535-7163.MCT-18-0919 |
2020 |
DNA Damage Response Inhibitor Combinations Exert Synergistic Antitumor Activity in Aggressive B-Cell Lymphomas. |
ATR |
| 26 |
31123088 |
10.1158/0008-5472.CAN-18-2480 |
2020 |
Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress. |
ATR |
| 27 |
31612875 |
10.1039/c9an01731c |
2020 |
Developing infrared spectroscopic detection for stratifying brain tumour patients: glioblastoma multiforme vs. lymphoma. |
ATR |
| 28 |
31721781 |
10.1371/journal.pone.0221288 |
2020 |
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. |
ATR |
| 29 |
32605100 |
10.3390/cancers12071710 |
2020 |
Stratifying Brain Tumour Histological Sub-Types: The Application of ATR-FTIR Serum Spectroscopy in Secondary Care. |
ATR |
| 30 |
32892059 |
10.1016/j.ctrv.2020.102090 |
2020 |
Targeting the DNA damage response for patients with lymphoma: Preclinical and clinical evidences. |
ATR |
| 31 |
33109561 |
10.21873/anticanres.14644 |
2020 |
3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation. |
ATR |
| 32 |
29209060 |
10.1038/s41598-017-17027-4 |
2019 |
ATR-FTIR spectral discrimination between normal and tumorous mouse models of lymphoma and melanoma from serum samples. |
ATR |
| 33 |
30266823 |
10.1182/bloodadvances.2018021592 |
2019 |
Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by <i>Mll-Af4</i> and activated <i>Ras</i>. |
ATR |
| 34 |
30569095 |
10.3892/mmr.2018.9745 |
2019 |
Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro. |
ATR |
| 35 |
27602488 |
10.18632/oncotarget.11785 |
2018 |
Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells. |
ATR |
| 36 |
28654064 |
10.3791/55703 |
2018 |
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay. |
ATR |
| 37 |
28796244 |
10.1038/cddis.2017.383 |
2018 |
BET bromodomain inhibitors synergize with ATR inhibitors in melanoma. |
ATR |
| 38 |
29144413 |
10.3390/v9110341 |
2018 |
Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle. |
ATR |
| 39 |
29179029 |
10.1016/j.leukres.2017.08.007 |
2018 |
3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. |
ATR |
| 40 |
29442041 |
10.1691/ph.2017.7676 |
2018 |
The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells. |
ATR |
| 41 |
30068867 |
10.1248/bpb.b17-00930 |
2018 |
Qiliqiangxin Protects against Renal Injury in Rat with Cardiorenal Syndrome Type I through Regulating the Inflammatory and Oxidative Stress Signaling. |
ATR |
| 42 |
30193222 |
10.1016/j.envpol.2018.08.070 |
2018 |
Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis. |
ATR |
| 43 |
26804177 |
10.1038/onc.2015.521 |
2017 |
BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. |
ATR |
| 44 |
27113195 |
10.1111/acel.12476 |
2017 |
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. |
ATR |
| 45 |
27239034 |
10.1016/j.celrep.2016.05.008 |
2017 |
Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis. |
ATR |
| 46 |
27743911 |
10.1016/j.jdermsci.2016.09.010 |
2017 |
Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation. |
ATR |
| 47 |
28032863 |
10.1038/cddis.2016.425 |
2017 |
Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells. |
ATR |
| 48 |
28098859 |
10.3892/ijmm.2017.2861 |
2017 |
DNA damage response defect in Williams-Beuren syndrome. |
ATR |
| 49 |
28479198 |
10.1016/j.bmcl.2017.04.026 |
2017 |
Sulfoximines as ATR inhibitors: Analogs of VE-821. |
ATR |
| 50 |
28808226 |
10.1038/s41467-017-00221-3 |
2017 |
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. |
ATR |
| 51 |
26061708 |
10.18632/oncotarget.4093 |
2016 |
rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis. |
ATR |
| 52 |
26075868 |
10.3390/ijms160613490 |
2016 |
Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System. |
ATR |
| 53 |
26189912 |
10.1038/srep12082 |
2016 |
Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo. |
ATR |
| 54 |
26312880 |
10.1016/S0140-6736(15)60373-7 |
2016 |
Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway. |
ATR |
| 55 |
26743341 |
10.1016/j.bbmt.2015.12.022 |
2016 |
Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies. |
ATR |
| 56 |
27656146 |
10.3389/fphar.2016.00301 |
2016 |
Protective Effect of Cyanidin-3-O-Glucoside against Ultraviolet B Radiation-Induced Cell Damage in Human HaCaT Keratinocytes. |
ATR |
| 57 |
25132270 |
10.1038/onc.2014.248 |
2015 |
CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress. |
ATR |
| 58 |
25232030 |
10.1158/1541-7786.MCR-14-0240 |
2015 |
A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function. |
ATR |
| 59 |
25597668 |
10.1016/j.jes.2014.05.032 |
2015 |
Modulation of the DNA repair system and ATR-p53 mediated apoptosis is relevant for tributyltin-induced genotoxic effects in human hepatoma G2 cells. |
ATR |
| 60 |
25970242 |
10.1038/nature14351 |
2015 |
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. |
ATR |
| 61 |
23761041 |
10.1126/scitranslmed.3005814 |
2014 |
Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors. |
ATR |
| 62 |
24690081 |
10.1111/bjh.12851 |
2014 |
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. |
ATR |
| 63 |
23352430 |
10.1016/j.cell.2013.01.006 |
2013 |
Identification of early replicating fragile sites that contribute to genome instability. |
ATR |
| 64 |
23383325 |
10.1371/journal.pone.0055361 |
2013 |
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance. |
ATR |
| 65 |
23403624 |
10.1182/blood-2012-08-446096 |
2013 |
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas. |
ATR |
| 66 |
21980358 |
10.1371/journal.pone.0024813 |
2012 |
Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis. |
ATR |
| 67 |
22030621 |
10.4161/cc.10.20.17887 |
2012 |
Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. |
ATR |
| 68 |
22120667 |
10.1038/nsmb.2189 |
2012 |
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. |
ATR |
| 69 |
22188649 |
10.1016/j.dnarep.2011.11.005 |
2012 |
ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity. |
ATR |
| 70 |
21098704 |
10.1158/0008-5472.CAN-10-2286 |
2011 |
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. |
ATR |
| 71 |
19244116 |
10.1158/0008-5472.CAN-08-3016 |
2009 |
Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway. |
ATR |
| 72 |
19405121 |
10.1002/ijc.24450 |
2009 |
BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells. |
ATR |
| 73 |
19514131 |
10.1016/j.abb.2009.01.018 |
2009 |
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. |
ATR |
| 74 |
18089799 |
10.1158/0008-5472.CAN-07-1610 |
2008 |
The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression. |
ATR |
| 75 |
18346918 |
10.1016/j.bcmd.2008.02.003 |
2008 |
BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. |
ATR |
| 76 |
18357388 |
|
2008 |
ATR alterations in Hodgkin's lymphoma. |
ATR |
| 77 |
18564221 |
10.1111/j.1939-1676.2008.0133.x |
2008 |
Cancer incidence in pet dogs: findings of the Animal Tumor Registry of Genoa, Italy. |
ATR |
| 78 |
16920159 |
10.1016/j.mrfmmm.2006.06.016 |
2007 |
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks. |
ATR |
| 79 |
17558410 |
10.1038/ni1478 |
2007 |
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. |
ATR |
| 80 |
17664422 |
10.1073/pnas.0701953104 |
2007 |
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. |
ATR |
| 81 |
16542220 |
10.1111/j.1349-7006.2006.00165.x |
2006 |
Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability. |
ATR |
| 82 |
16827800 |
10.1111/j.1349-7006.2006.00226.x |
2006 |
Alterations in ATR in nasal NK/T-cell lymphoma and chronic active Epstein-Barr virus infection. |
ATR |
| 83 |
15696190 |
10.1038/labinvest.3700235 |
2005 |
Alterations of DNA damage-response genes ATM and ATR in pyothorax-associated lymphoma. |
ATR |
| 84 |
15965469 |
10.1038/ncb1270 |
2005 |
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. |
ATR |
| 85 |
15359640 |
10.1080/10428194042000191738 |
2004 |
Chromosomal instability and ATR amplification gene in patients with persistent and polyclonal B-cell lymphocytosis (PPBL). |
ATR |
| 86 |
7670397 |
|
1995 |
Successful engraftment after autologous transplantation of 10-day cultured bone marrow activated by interleukin 2 in patients with acute lymphoblastic leukemia. |
ATR |
| 87 |
8389993 |
10.1159/000126360 |
1993 |
Neuroendocrine control of immunoreactive growth hormone and bioactive prolactin secretion in neonatal rats: ontogeny and interactions between the serotonergic, cholinergic and alpha 2-adrenergic systems. |
ATR |
Datasets
Models
