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{
"cells": [
{
"cell_type": "code",
"execution_count": 17,
"id": "f51e6ed2-079a-4a9c-a41d-02a11c95954c",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:08:54.360100Z",
"iopub.status.busy": "2021-09-23T06:08:54.356702Z",
"iopub.status.idle": "2021-09-23T06:08:59.232023Z",
"shell.execute_reply": "2021-09-23T06:08:59.230494Z"
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"tags": [],
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"outputs": [
{
"name": "stderr",
"output_type": "stream",
"text": [
"snapshotDate(): 2020-10-27\n",
"\n"
]
}
],
"source": [
"library(ExperimentHub)\n",
"library(HDF5Array)\n",
"library(SummarizedExperiment)\n",
"eh <- ExperimentHub() \n",
"setwd(\"/data/ExtraDisk/sdd/longzhilin/Data/drugData/CMAP_LINCS_2020\")"
]
},
{
"cell_type": "code",
"execution_count": 18,
"id": "997d397b-78a1-4caa-9f02-57c6a7d7bfe0",
"metadata": {
"collapsed": true,
"execution": {
"iopub.execute_input": "2021-09-23T06:10:39.616836Z",
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"shell.execute_reply": "2021-09-23T06:11:13.487016Z"
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},
"outputs": [
{
"data": {
"text/plain": [
"ExperimentHub with 4 records\n",
"# snapshotDate(): 2020-10-27\n",
"# $dataprovider: Broad Institute, DrugBank, Broad Institute, STITCH\n",
"# $species: Homo sapiens\n",
"# $rdataclass: character, list\n",
"# additional mcols(): taxonomyid, genome, description,\n",
"# coordinate_1_based, maintainer, rdatadateadded, preparerclass, tags,\n",
"# rdatapath, sourceurl, sourcetype \n",
"# retrieve records with, e.g., 'object[[\"EH3226\"]]' \n",
"\n",
" title \n",
" EH3226 | lincs \n",
" EH3227 | lincs_expr \n",
" EH3228 | dtlink_db_clue_sti\n",
" EH3233 | taurefList "
]
},
"metadata": {},
"output_type": "display_data"
},
{
"name": "stderr",
"output_type": "stream",
"text": [
"see ?signatureSearchData and browseVignettes('signatureSearchData') for documentation\n",
"\n",
"loading from cache\n",
"\n"
]
},
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 3 × 5</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>group</th><th scope=col>name</th><th scope=col>otype</th><th scope=col>dclass</th><th scope=col>dim</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>0</th><td>/</td><td>assay </td><td>H5I_DATASET</td><td>FLOAT </td><td>12328 x 45956</td></tr>\n",
"\t<tr><th scope=row>1</th><td>/</td><td>colnames</td><td>H5I_DATASET</td><td>STRING</td><td>45956 x 1 </td></tr>\n",
"\t<tr><th scope=row>2</th><td>/</td><td>rownames</td><td>H5I_DATASET</td><td>STRING</td><td>12328 x 1 </td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 3 × 5\n",
"\\begin{tabular}{r|lllll}\n",
" & group & name & otype & dclass & dim\\\\\n",
" & <chr> & <chr> & <chr> & <chr> & <chr>\\\\\n",
"\\hline\n",
"\t0 & / & assay & H5I\\_DATASET & FLOAT & 12328 x 45956\\\\\n",
"\t1 & / & colnames & H5I\\_DATASET & STRING & 45956 x 1 \\\\\n",
"\t2 & / & rownames & H5I\\_DATASET & STRING & 12328 x 1 \\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 3 × 5\n",
"\n",
"| <!--/--> | group <chr> | name <chr> | otype <chr> | dclass <chr> | dim <chr> |\n",
"|---|---|---|---|---|---|\n",
"| 0 | / | assay | H5I_DATASET | FLOAT | 12328 x 45956 |\n",
"| 1 | / | colnames | H5I_DATASET | STRING | 45956 x 1 |\n",
"| 2 | / | rownames | H5I_DATASET | STRING | 12328 x 1 |\n",
"\n"
],
"text/plain": [
" group name otype dclass dim \n",
"0 / assay H5I_DATASET FLOAT 12328 x 45956\n",
"1 / colnames H5I_DATASET STRING 45956 x 1 \n",
"2 / rownames H5I_DATASET STRING 12328 x 1 "
]
},
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"output_type": "display_data"
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"data": {
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"<caption>A matrix: 12328 × 45956 of type dbl</caption>\n",
"<thead>\n",
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"</thead>\n",
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"\t<tr><th scope=row>3315</th><td>-0.22889999</td><td>-1.1686</td><td> 1.73409986</td><td> 0.21175002</td><td>-3.493849993</td><td> 0.21799627</td><td>-0.32495001</td><td>-2.3188000</td><td>-0.12619999</td><td>-0.08780000</td><td>⋯</td><td> 0.0000</td><td>-0.5599</td><td>-0.7747</td><td> 0.9959</td><td>-0.9554</td><td>-0.6129</td><td> 2.3237</td><td>-0.7365</td><td>-0.4083</td><td>-3.0874</td></tr>\n",
"\t<tr><th scope=row>5289</th><td> 0.04359999</td><td> 3.6465</td><td> 3.03125000</td><td> 0.90630001</td><td> 0.187049985</td><td> 3.19396544</td><td>-0.23465000</td><td> 1.0276000</td><td>-0.56045002</td><td>-0.05330001</td><td>⋯</td><td> 0.8281</td><td>-0.9206</td><td> 0.6822</td><td>-0.9480</td><td>-0.2322</td><td>-1.1048</td><td> 0.8300</td><td> 0.4654</td><td>-0.5206</td><td> 0.6745</td></tr>\n",
"\t<tr><th scope=row>868</th><td> 0.10220000</td><td> 0.8592</td><td> 1.81244993</td><td>-0.25509998</td><td> 0.549250007</td><td>-0.19470868</td><td>-0.59965003</td><td> 0.4235500</td><td>-0.48370001</td><td>-1.28314996</td><td>⋯</td><td> 0.1421</td><td> 0.7650</td><td> 0.4446</td><td> 0.2584</td><td> 0.1067</td><td> 0.5922</td><td> 1.3067</td><td>-0.8527</td><td>-0.3135</td><td> 0.8328</td></tr>\n",
"\t<tr><th scope=row>1677</th><td>-0.20805000</td><td> 0.7930</td><td> 1.97329998</td><td> 0.54895002</td><td>-0.111049995</td><td> 1.75220299</td><td>-0.52419996</td><td> 0.9599000</td><td>-0.76335001</td><td>-0.10170000</td><td>⋯</td><td> 0.3969</td><td> 0.9042</td><td> 0.0418</td><td> 0.4508</td><td> 0.3277</td><td> 4.0569</td><td>-3.5420</td><td>-0.8606</td><td>-0.0633</td><td> 2.4948</td></tr>\n",
"\t<tr><th scope=row>7043</th><td>-0.27850002</td><td> 2.4205</td><td> 0.82440001</td><td>-0.50725001</td><td> 1.212399960</td><td>-0.33966029</td><td>-0.46219999</td><td> 0.2445500</td><td>-0.48930001</td><td> 0.63644999</td><td>⋯</td><td> 0.0147</td><td> 1.1314</td><td> 1.5184</td><td> 1.1396</td><td>-0.7535</td><td>-0.1550</td><td>-0.5552</td><td> 0.9483</td><td> 0.5121</td><td> 0.9929</td></tr>\n",
"\t<tr><th scope=row>5613</th><td>-0.66865003</td><td> 0.5340</td><td> 3.83539987</td><td> 0.60944998</td><td>-1.195199966</td><td> 1.74077058</td><td>-0.14775001</td><td>-0.1435000</td><td> 0.24705002</td><td> 0.45889997</td><td>⋯</td><td> 0.0717</td><td> 0.5023</td><td> 0.3477</td><td>-2.3664</td><td>-0.3586</td><td>-0.3032</td><td>-0.4723</td><td>-0.3586</td><td>-0.7751</td><td> 1.1149</td></tr>\n",
"\t<tr><th scope=row>⋮</th><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋱</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td></tr>\n",
"\t<tr><th scope=row>54552</th><td>-0.547550023</td><td> 0.5666</td><td> 0.74390000</td><td>-0.32515001</td><td> 1.286950111</td><td> 0.6714719</td><td>-0.372799993</td><td> 1.4985501</td><td>-0.04715000</td><td>-0.15339999</td><td>⋯</td><td> 1.8504</td><td>-0.2516</td><td> 1.3114</td><td>-0.1993</td><td>-1.4090</td><td>-0.4407</td><td>-2.0924</td><td> 0.6877</td><td> 0.7649</td><td>-0.1186</td></tr>\n",
"\t<tr><th scope=row>54920</th><td>-0.190850005</td><td> 2.6847</td><td> 0.61905003</td><td> 0.51645005</td><td>-0.408650011</td><td> 1.7125645</td><td>-0.076900005</td><td>-0.5360000</td><td>-1.17120004</td><td> 0.30594999</td><td>⋯</td><td> 0.4583</td><td> 0.8514</td><td> 0.3027</td><td> 1.4400</td><td>-1.0779</td><td>-0.6745</td><td> 0.0638</td><td> 0.4723</td><td> 0.0850</td><td> 0.7503</td></tr>\n",
"\t<tr><th scope=row>11178</th><td>-0.007799983</td><td> 1.4589</td><td> 0.63424999</td><td>-0.62494999</td><td> 0.307300001</td><td>-0.3424515</td><td>-0.897199988</td><td> 0.0240500</td><td>-0.16354999</td><td> 0.00515002</td><td>⋯</td><td>-1.7519</td><td> 0.3908</td><td>-1.0155</td><td>-0.2487</td><td>-0.6887</td><td>-0.6171</td><td>-0.5462</td><td>-0.1172</td><td>-1.4105</td><td> 0.1631</td></tr>\n",
"\t<tr><th scope=row>93643</th><td>-0.781599998</td><td> 0.9777</td><td> 2.61190009</td><td> 0.64004999</td><td> 0.713050008</td><td> 0.9237132</td><td> 0.206200004</td><td> 0.4028500</td><td> 0.18150002</td><td>-1.33759999</td><td>⋯</td><td> 2.1395</td><td>-0.4617</td><td> 1.2257</td><td> 0.0263</td><td>-1.3893</td><td>-1.9883</td><td> 0.7824</td><td> 0.2161</td><td>-0.5916</td><td> 2.0450</td></tr>\n",
"\t<tr><th scope=row>112869</th><td>-0.174050003</td><td> 0.1336</td><td>-0.16070001</td><td> 0.83440006</td><td> 0.434750021</td><td> 0.5052795</td><td> 0.133000001</td><td>-0.2637000</td><td>-0.80325001</td><td>-0.37760001</td><td>⋯</td><td> 2.3786</td><td> 1.1703</td><td> 1.1386</td><td> 0.7210</td><td>-0.1182</td><td>-0.0510</td><td>-1.0956</td><td> 0.8456</td><td>-0.5989</td><td> 1.1402</td></tr>\n",
"\t<tr><th scope=row>51147</th><td>-0.131500006</td><td> 2.5702</td><td> 2.79585004</td><td> 0.60960001</td><td> 1.184949994</td><td> 0.1883786</td><td>-0.194200009</td><td> 0.8002999</td><td>-0.16949999</td><td> 0.07554999</td><td>⋯</td><td> 1.9107</td><td> 1.5612</td><td> 0.3518</td><td> 1.2840</td><td>-1.4728</td><td>-0.3504</td><td> 0.0130</td><td> 0.4459</td><td>-0.4840</td><td> 0.9162</td></tr>\n",
"\t<tr><th scope=row>196403</th><td>-0.179949999</td><td> 3.3629</td><td> 2.99699998</td><td> 1.06465006</td><td> 0.325349987</td><td> 1.2875153</td><td>-0.328400016</td><td> 1.8518502</td><td>-0.13325000</td><td>-1.07975006</td><td>⋯</td><td> 1.4798</td><td> 0.1850</td><td> 1.3844</td><td> 0.3240</td><td>-0.4564</td><td> 0.3414</td><td> 0.1307</td><td> 0.2026</td><td>-1.4586</td><td> 1.7090</td></tr>\n",
"\t<tr><th scope=row>389677</th><td>-0.299800009</td><td>-1.7546</td><td> 1.62085009</td><td> 0.17885001</td><td> 0.346049994</td><td> 2.1395676</td><td> 0.425999999</td><td> 0.2757500</td><td>-0.60355002</td><td>-0.66229999</td><td>⋯</td><td> 0.6175</td><td>-0.6872</td><td> 1.1080</td><td>-0.3949</td><td>-0.7650</td><td> 0.6032</td><td>-0.5789</td><td> 0.8575</td><td> 1.2912</td><td>-0.5854</td></tr>\n",
"\t<tr><th scope=row>1296</th><td>-0.568499982</td><td> 4.0283</td><td> 1.80404997</td><td> 0.68540001</td><td> 1.193750024</td><td>-0.3998278</td><td>-0.204600006</td><td> 2.2550499</td><td> 0.10470000</td><td> 0.11945000</td><td>⋯</td><td> 0.9755</td><td> 0.6923</td><td>-0.1845</td><td> 0.1797</td><td>-0.0929</td><td> 0.0885</td><td> 0.6156</td><td> 0.2872</td><td>-0.6606</td><td> 0.7912</td></tr>\n",
"\t<tr><th scope=row>85352</th><td>-0.582249999</td><td> 2.8892</td><td> 2.65304995</td><td> 0.62145001</td><td> 0.426599979</td><td> 1.1645755</td><td> 0.086000010</td><td> 1.2165500</td><td> 0.69494998</td><td>-0.19315001</td><td>⋯</td><td>-0.0009</td><td> 3.7638</td><td> 1.6589</td><td> 0.1591</td><td>-0.6720</td><td>-1.0518</td><td>-1.5408</td><td>-0.1605</td><td> 0.1139</td><td> 2.4243</td></tr>\n",
"\t<tr><th scope=row>57610</th><td> 0.498400003</td><td> 5.1220</td><td> 2.16345000</td><td> 0.01574999</td><td> 0.200550005</td><td> 0.1731201</td><td>-0.926600039</td><td> 0.0807500</td><td>-0.57225001</td><td> 0.07119998</td><td>⋯</td><td> 1.5447</td><td>-0.0599</td><td> 1.6722</td><td> 0.2858</td><td> 1.6272</td><td>-0.8244</td><td> 0.9907</td><td> 0.4710</td><td> 0.1368</td><td> 1.4276</td></tr>\n",
"\t<tr><th scope=row>27147</th><td>-0.202250004</td><td> 2.5838</td><td> 1.67175007</td><td>-0.22469999</td><td> 1.058600068</td><td> 0.6260329</td><td>-0.410300016</td><td> 0.1346500</td><td>-0.54540002</td><td>-0.01105000</td><td>⋯</td><td> 1.3721</td><td>-0.4534</td><td>-0.3415</td><td> 0.3251</td><td>-1.3887</td><td> 0.4315</td><td> 0.1750</td><td>-0.6396</td><td>-1.0847</td><td> 1.3937</td></tr>\n",
"\t<tr><th scope=row>79591</th><td> 1.026950002</td><td> 2.7480</td><td>-0.06799999</td><td> 0.64854997</td><td> 1.501299977</td><td> 1.2647009</td><td> 0.523100019</td><td>-0.0559500</td><td> 0.24710000</td><td> 0.37870002</td><td>⋯</td><td> 2.1479</td><td> 1.1361</td><td>-0.7604</td><td> 1.6378</td><td>-0.0226</td><td> 0.0510</td><td>-0.0003</td><td>-0.4592</td><td> 0.8158</td><td> 1.6554</td></tr>\n",
"\t<tr><th scope=row>92595</th><td> 0.652800024</td><td>-0.7214</td><td> 0.21370000</td><td> 0.66485000</td><td> 1.284350038</td><td> 0.5647974</td><td> 0.559400022</td><td> 1.5563999</td><td> 0.02030000</td><td>-0.36090001</td><td>⋯</td><td> 0.3339</td><td> 1.3473</td><td> 0.0010</td><td> 0.0615</td><td>-0.2524</td><td> 0.0479</td><td>-0.3532</td><td>-0.2950</td><td> 0.0858</td><td> 0.1184</td></tr>\n",
"\t<tr><th scope=row>51063</th><td> 0.343500018</td><td>-0.8015</td><td> 0.33515000</td><td> 1.91869998</td><td> 0.368699998</td><td> 0.5586674</td><td>-0.298150003</td><td> 0.2594000</td><td> 0.28309998</td><td> 0.09540004</td><td>⋯</td><td> 0.9597</td><td> 1.8933</td><td> 1.1444</td><td> 0.9759</td><td>-0.1300</td><td>-0.5763</td><td>-0.3481</td><td>-1.0736</td><td>-0.0896</td><td> 1.2923</td></tr>\n",
"\t<tr><th scope=row>55223</th><td>-0.215350002</td><td> 4.3713</td><td> 1.97140002</td><td> 0.29425001</td><td> 1.258400083</td><td> 0.8483824</td><td> 0.505299985</td><td> 0.4320000</td><td>-0.73879999</td><td>-1.00734997</td><td>⋯</td><td>-0.7425</td><td> 1.5926</td><td> 0.3204</td><td> 0.3486</td><td>-1.2565</td><td>-0.0055</td><td>-0.3076</td><td>-0.5895</td><td>-0.6759</td><td> 1.1372</td></tr>\n",
"\t<tr><th scope=row>80022</th><td>-0.499350011</td><td> 3.3540</td><td> 2.46420002</td><td> 0.21785000</td><td>-0.007000007</td><td> 1.1016043</td><td> 0.208849996</td><td>-0.3577000</td><td>-0.80614996</td><td> 0.93999994</td><td>⋯</td><td> 1.0909</td><td> 0.1379</td><td> 0.6538</td><td> 0.9385</td><td>-0.8598</td><td>-0.1190</td><td>-1.1109</td><td> 0.0832</td><td>-0.2971</td><td> 0.8936</td></tr>\n",
"\t<tr><th scope=row>55589</th><td> 0.989849985</td><td>-1.7614</td><td>-0.52405000</td><td>-0.53944999</td><td> 2.766950130</td><td>-1.4092908</td><td> 0.037900001</td><td> 0.5296500</td><td> 0.20385003</td><td>-0.57599998</td><td>⋯</td><td>-1.7398</td><td> 1.1566</td><td>-0.5645</td><td> 1.4264</td><td> 1.8400</td><td>-0.1273</td><td> 1.2060</td><td> 0.2184</td><td> 1.3779</td><td>-0.5626</td></tr>\n",
"\t<tr><th scope=row>376267</th><td>-0.697149992</td><td> 1.8690</td><td> 0.45809996</td><td>-0.03180003</td><td> 1.338700056</td><td>-0.2823215</td><td>-0.157900006</td><td> 1.0916001</td><td>-0.20415001</td><td>-0.42180002</td><td>⋯</td><td> 0.1199</td><td> 1.2685</td><td> 0.9052</td><td> 0.0267</td><td> 0.0809</td><td>-1.1636</td><td> 0.2976</td><td> 1.9446</td><td>-0.9014</td><td> 1.8036</td></tr>\n",
"\t<tr><th scope=row>84820</th><td>-0.152749985</td><td> 1.8001</td><td> 1.37894988</td><td> 0.01440001</td><td> 1.192999959</td><td> 1.6359860</td><td>-0.251900017</td><td> 1.5041499</td><td>-0.12639999</td><td>-0.49724999</td><td>⋯</td><td> 1.1424</td><td>-0.0597</td><td> 0.7671</td><td> 0.5935</td><td>-0.5742</td><td>-1.0844</td><td>-0.5707</td><td> 2.0601</td><td>-0.2694</td><td> 1.1255</td></tr>\n",
"\t<tr><th scope=row>2931</th><td>-0.489800006</td><td> 4.3996</td><td> 2.27640009</td><td> 0.27145001</td><td>-0.035150021</td><td> 0.5720488</td><td>-0.576700032</td><td> 0.1173000</td><td>-0.68005002</td><td> 0.33640003</td><td>⋯</td><td> 0.2727</td><td> 0.5013</td><td> 0.8471</td><td> 0.2688</td><td> 0.7681</td><td>-0.5762</td><td>-0.8154</td><td>-0.0992</td><td>-0.7370</td><td> 1.7226</td></tr>\n",
"\t<tr><th scope=row>63876</th><td>-0.252000004</td><td> 2.4605</td><td> 1.21990001</td><td>-0.08165000</td><td> 1.008049965</td><td> 0.7371939</td><td>-0.005400002</td><td> 0.2307501</td><td>-0.44770002</td><td>-0.46705002</td><td>⋯</td><td>-0.7579</td><td>-0.6265</td><td> 0.8404</td><td>-0.2692</td><td> 0.8911</td><td>-0.2046</td><td>-0.8071</td><td>-0.1506</td><td>-1.6715</td><td> 0.9172</td></tr>\n",
"\t<tr><th scope=row>51275</th><td>-0.829549968</td><td> 2.4557</td><td> 2.40814996</td><td> 0.42320001</td><td>-0.335050017</td><td>-0.9146695</td><td> 0.963299990</td><td> 1.4400499</td><td> 0.39770001</td><td> 0.27579999</td><td>⋯</td><td> 0.3883</td><td> 0.6793</td><td> 0.3237</td><td>-0.4276</td><td> 0.7665</td><td> 0.5685</td><td>-1.0498</td><td> 1.5715</td><td>-1.7042</td><td>-0.0870</td></tr>\n",
"\t<tr><th scope=row>158747</th><td>-0.933599949</td><td> 2.2661</td><td> 2.48624992</td><td> 1.50850010</td><td>-1.788749933</td><td>-0.1306736</td><td>-0.646350026</td><td>-1.1307499</td><td> 0.18900004</td><td> 1.36570001</td><td>⋯</td><td> 2.4502</td><td> 1.9125</td><td> 0.2526</td><td> 0.5455</td><td> 0.1402</td><td>-0.9180</td><td>-1.9362</td><td> 1.3076</td><td>-0.5795</td><td> 0.3890</td></tr>\n",
"\t<tr><th scope=row>283232</th><td>-0.549999952</td><td> 1.0838</td><td> 0.41525000</td><td>-0.09474999</td><td> 1.855700016</td><td>-0.2727659</td><td>-0.094699994</td><td> 1.7906501</td><td>-0.75310004</td><td> 0.58985001</td><td>⋯</td><td> 0.3257</td><td> 1.1194</td><td> 0.5754</td><td>-0.4345</td><td>-3.3375</td><td> 0.5196</td><td>-1.5637</td><td> 1.1416</td><td> 0.2517</td><td>-0.1119</td></tr>\n",
"\t<tr><th scope=row>25960</th><td> 0.060000002</td><td> 1.8776</td><td> 0.34240001</td><td>-0.22815000</td><td> 1.623250008</td><td>-0.5708635</td><td> 0.072649986</td><td> 0.1602500</td><td> 0.26474997</td><td> 0.05900000</td><td>⋯</td><td> 0.8320</td><td>-0.3680</td><td> 0.6608</td><td>-0.2463</td><td>-2.4105</td><td> 0.1107</td><td>-0.2676</td><td> 0.6119</td><td> 1.1775</td><td> 0.9155</td></tr>\n",
"\t<tr><th scope=row>6376</th><td>-0.391449988</td><td> 2.0942</td><td> 1.54129994</td><td> 0.29714999</td><td>-0.322299987</td><td> 0.6695740</td><td> 0.684000015</td><td>-0.2364000</td><td>-0.22969997</td><td>-1.19679999</td><td>⋯</td><td> 1.1901</td><td>-0.0144</td><td> 1.5630</td><td> 0.3335</td><td> 1.0411</td><td>-1.1291</td><td> 0.6466</td><td> 1.4029</td><td>-1.0273</td><td> 0.0192</td></tr>\n",
"\t<tr><th scope=row>11033</th><td>-0.816999972</td><td> 0.0360</td><td> 1.86659992</td><td> 1.18130004</td><td>-1.078150034</td><td> 2.5671935</td><td>-0.160849988</td><td> 0.1246000</td><td> 1.15509999</td><td> 0.12650001</td><td>⋯</td><td> 1.2484</td><td>-0.1491</td><td> 0.0777</td><td> 0.3478</td><td>-0.7770</td><td>-0.2837</td><td>-0.0944</td><td> 0.7815</td><td>-0.3094</td><td> 2.2588</td></tr>\n",
"\t<tr><th scope=row>54869</th><td>-0.491949975</td><td> 3.9373</td><td> 2.89374995</td><td> 0.08510001</td><td>-1.110100031</td><td> 1.1950539</td><td>-0.178350002</td><td> 1.4240000</td><td>-0.01594999</td><td> 1.36944997</td><td>⋯</td><td>-0.1743</td><td> 1.0657</td><td> 0.7791</td><td> 1.0932</td><td>-0.5247</td><td>-0.5104</td><td>-0.2863</td><td>-0.5035</td><td> 1.2087</td><td> 2.5072</td></tr>\n",
"\t<tr><th scope=row>60</th><td>-0.487500012</td><td>-0.0225</td><td>-0.53219998</td><td>-0.72780001</td><td>-0.636449993</td><td>-0.1309013</td><td>-0.509249985</td><td>-0.4348000</td><td> 0.53165001</td><td> 0.25479999</td><td>⋯</td><td>-1.4556</td><td>-0.2475</td><td>-0.6307</td><td>-0.2042</td><td> 0.7773</td><td> 0.3077</td><td> 1.8114</td><td>-1.0285</td><td> 0.0535</td><td>-1.3198</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A matrix: 12328 × 45956 of type dbl\n",
"\\begin{tabular}{r|lllllllllllllllllllll}\n",
" & BRD-A03772856\\_\\_CD34\\_\\_trt\\_cp & trichostatin-a\\_\\_CD34\\_\\_trt\\_cp & geldanamycin\\_\\_CD34\\_\\_trt\\_cp & KUC107191N\\_\\_CD34\\_\\_trt\\_cp & BRD-A35207501\\_\\_CD34\\_\\_trt\\_cp & iloprost\\_\\_CD34\\_\\_trt\\_cp & BRD-A72498772\\_\\_CD34\\_\\_trt\\_cp & BRD-A72796238\\_\\_CD34\\_\\_trt\\_cp & BRD-A73513677\\_\\_CD34\\_\\_trt\\_cp & BRD-A73558769\\_\\_CD34\\_\\_trt\\_cp & ⋯ & MW-MITF24\\_\\_MCF7\\_\\_trt\\_cp & l-buthionine-sulfoximine\\_\\_PC3\\_\\_trt\\_cp & alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & cisplatin\\_\\_PC3\\_\\_trt\\_cp & iniparib\\_\\_PC3\\_\\_trt\\_cp & JMW-MITF1\\_\\_PC3\\_\\_trt\\_cp & bortezomib\\_\\_PC3\\_\\_trt\\_cp & selumetinib\\_\\_PC3\\_\\_trt\\_cp & glutamine\\_\\_PC3\\_\\_trt\\_cp & MW-MITF24\\_\\_PC3\\_\\_trt\\_cp\\\\\n",
"\\hline\n",
"\t5720 & 0.36540002 & -1.9333 & -1.78014994 & -0.61925000 & -0.729250073 & -2.01719809 & 0.18455000 & -1.1793000 & 0.34680000 & 0.10225001 & ⋯ & -2.1606 & -0.2913 & -1.2731 & -0.5659 & 0.4571 & 0.0308 & -0.2913 & -0.9489 & -1.0550 & -1.9929\\\\\n",
"\t466 & 0.69385004 & -4.0653 & -2.45910001 & 0.05739999 & 1.069949985 & -1.52120280 & -0.19575000 & 1.3569000 & 0.32670000 & 0.36719999 & ⋯ & -1.9576 & -0.6859 & 0.5907 & -0.2468 & 0.7582 & 0.4957 & -1.0830 & 0.3153 & 1.3292 & -0.5015\\\\\n",
"\t6009 & 0.55435002 & 0.1850 & 0.22250000 & 0.05124998 & 0.336199999 & -1.32433784 & 0.78560001 & -0.2471000 & 1.50240004 & -0.47415000 & ⋯ & -1.9373 & -0.7577 & -1.8149 & 0.0000 & 0.3941 & -1.6190 & 0.1462 & -2.1747 & -0.2952 & -2.1053\\\\\n",
"\t2309 & -0.31579998 & 2.2660 & 0.67035002 & -0.39039999 & 1.141200066 & 0.91430640 & 0.45165002 & 0.1099000 & -0.58609998 & -1.34329998 & ⋯ & 0.9808 & -0.0848 & -1.5376 & 0.6194 & -0.2978 & 0.5139 & 2.9324 & -0.9933 & -0.0140 & -1.1789\\\\\n",
"\t387 & 0.37180001 & -0.2558 & -2.59875011 & -2.12490010 & 1.495700002 & -3.34633827 & -0.03835000 & -0.9017001 & 1.18655002 & 0.68274999 & ⋯ & -1.5168 & 0.0997 & -0.3862 & 0.1973 & -0.4246 & -0.5682 & 0.6157 & -0.3696 & 0.3436 & -3.2787\\\\\n",
"\t3553 & 0.70824999 & -0.5149 & -0.73619998 & -0.41515002 & 1.960999966 & 0.22129090 & -0.20070001 & 0.8321000 & 2.93820000 & -0.08945002 & ⋯ & 3.2767 & 0.0000 & -0.1367 & -0.6745 & -1.0342 & -1.3800 & -0.9713 & 1.2338 & -1.3174 & -0.6564\\\\\n",
"\t427 & 0.18295000 & -1.6045 & 0.42860001 & 0.30954999 & 1.228850007 & 0.06338993 & 0.44700000 & 0.3969500 & 0.57410002 & -0.11010003 & ⋯ & 0.5427 & -0.5669 & -0.7753 & -0.8029 & 1.6375 & 1.7251 & 1.2290 & 0.0243 & -0.7690 & -0.6058\\\\\n",
"\t5898 & -0.40434998 & 3.5042 & 2.97979999 & -0.84810001 & 1.905500054 & 0.31654096 & -0.01730000 & -0.1905500 & -0.82900000 & -0.52789998 & ⋯ & -0.3057 & 0.1609 & 0.2776 & 0.0750 & -2.8649 & 0.5809 & 1.7948 & -0.0093 & 1.2902 & 0.2903\\\\\n",
"\t23365 & 0.49500000 & 0.4630 & 0.48894998 & -0.25070000 & 0.521200001 & -0.62915254 & -0.67110002 & -0.7869500 & 0.49564999 & 1.38380003 & ⋯ & -0.7719 & -0.3665 & 0.7769 & 0.3405 & -0.6687 & 0.4276 & -2.5250 & 0.0963 & 0.0482 & 0.0963\\\\\n",
"\t6657 & -0.58120000 & 2.3181 & 1.18390000 & 0.32394999 & 0.963199973 & 1.12940836 & -0.09670001 & 1.5269001 & -0.28994998 & -0.26674998 & ⋯ & 2.3400 & 0.8720 & 1.4368 & 0.5604 & -1.3073 & -0.8898 & -0.4415 & 0.7747 & -0.3321 & 2.5004\\\\\n",
"\t5054 & -0.25055000 & -0.2075 & -0.43175000 & 0.16700003 & 1.369400024 & 1.35352969 & -0.11345001 & 0.5116500 & -0.07969996 & -0.21934998 & ⋯ & 0.6593 & 0.2299 & 0.5751 & 0.2370 & 0.4596 & 0.3050 & -1.6550 & 0.0137 & 0.4267 & 0.6745\\\\\n",
"\t3108 & -0.06060000 & -1.8116 & -1.61284995 & -0.08275000 & -0.534399986 & -0.13355637 & -0.01085000 & -1.5620000 & 0.59775001 & 0.97039998 & ⋯ & 0.6745 & 0.3049 & -0.5842 & -0.3346 & 1.3939 & -0.4618 & 0.4915 & 0.0590 & 0.1180 & 1.7550\\\\\n",
"\t1950 & 0.34324998 & -0.3875 & 1.33039999 & 0.69085002 & -1.051300049 & 3.66408134 & 0.38674998 & 2.6680501 & -0.73095000 & -0.51055002 & ⋯ & 0.8943 & 0.2505 & 1.1675 & -0.0811 & -0.4084 & -0.6610 & -0.0670 & 1.3110 & -1.1154 & 2.5754\\\\\n",
"\t351 & -0.75015002 & 0.0000 & 1.67859995 & 0.01835000 & 0.958649993 & 0.42959470 & 0.31160000 & 0.9131501 & 0.33724999 & -0.51849997 & ⋯ & 1.2067 & 0.8746 & -1.4754 & 0.3245 & 1.2609 & 0.4734 & 1.3987 & -0.1130 & -0.8090 & 0.3988\\\\\n",
"\t4846 & 0.44309998 & 2.6904 & 1.82799995 & 0.63379997 & 0.361950010 & 1.81054175 & 0.38900000 & 3.5537500 & -0.76929998 & -0.95864999 & ⋯ & -1.2723 & 1.0611 & 0.0000 & 0.8742 & 0.5819 & 0.4788 & 1.4877 & -0.3579 & -0.6335 & -0.7591\\\\\n",
"\t1452 & 0.05585000 & -0.3123 & 0.57295001 & -0.44580001 & 0.636549950 & -0.72561306 & -3.03379989 & -0.7344500 & 0.70099998 & 0.10130000 & ⋯ & -1.9790 & 0.3489 & -0.7107 & -1.8170 & 0.3777 & -1.1747 & 1.5557 & -0.0845 & -1.1233 & -1.5332\\\\\n",
"\t4776 & -0.92770004 & 0.6834 & 2.35645008 & 1.05629992 & -0.044949993 & 0.66652113 & -0.03335000 & 2.2428999 & 0.25165001 & 0.55704999 & ⋯ & 3.3373 & 0.5311 & 1.3320 & 0.3057 & -0.9554 & -0.9277 & -1.0772 & 0.3361 & -0.9042 & 3.1649\\\\\n",
"\t6908 & 0.20305002 & 1.6617 & -0.03129999 & 0.27434999 & 0.650349975 & -0.19393554 & -0.39605001 & 0.2097500 & 0.72994995 & 0.24660000 & ⋯ & -2.6201 & 0.3546 & -0.8340 & 0.1707 & 0.7447 & 0.8058 & -0.3623 & -1.9207 & 0.1919 & -1.5016\\\\\n",
"\t672 & 0.32475001 & -4.0764 & -3.70605016 & 0.08045001 & -0.453600019 & -0.40477309 & 0.57854998 & 0.4603500 & -0.35640001 & -0.57574999 & ⋯ & -0.0347 & 0.5236 & -1.3417 & 0.5860 & 0.7067 & -0.6479 & 2.8601 & 2.8988 & -0.1277 & 0.1526\\\\\n",
"\t5710 & 0.63964999 & 0.2391 & 0.23535000 & -1.49465001 & -1.058050036 & -1.23082113 & 0.30835003 & -1.5607500 & -1.05330002 & 1.03775001 & ⋯ & -0.8548 & 0.0244 & -0.4195 & 0.8007 & 0.8163 & -0.6469 & 2.6838 & -0.4705 & -1.5872 & -1.9920\\\\\n",
"\t2115 & -0.46765000 & 2.5311 & 0.92490000 & 0.27040002 & -0.008450001 & 1.54992425 & 0.02805001 & 0.9752501 & -0.80159998 & -0.07155001 & ⋯ & 1.7185 & 0.0407 & 0.8669 & -2.4175 & -1.3462 & 0.1283 & -0.6444 & 0.9818 & -0.0399 & 0.1548\\\\\n",
"\t7015 & -0.62810004 & 2.9025 & 1.92159998 & 0.28770000 & 0.454999983 & 1.53958702 & 0.56625003 & 0.9501500 & -0.29589999 & -0.62774998 & ⋯ & 1.2487 & 0.5907 & 0.8714 & 0.6421 & -0.9362 & -0.4963 & -0.4187 & 0.6203 & -0.1979 & 3.4552\\\\\n",
"\t8726 & 0.46415001 & -3.4828 & -2.23075008 & 0.99154997 & 0.230650008 & 0.27298701 & 0.02245000 & -0.7093000 & -0.07795000 & -0.39450002 & ⋯ & -1.6259 & -0.1834 & -0.9279 & -5.2129 & -0.4035 & 0.8041 & 1.4548 & 1.4854 & 1.7362 & 1.4854\\\\\n",
"\t2185 & -0.59829998 & -2.5377 & 4.76999998 & -0.27070001 & -2.783349991 & 1.25042439 & -0.24249998 & -3.3810499 & -0.36440000 & 0.63944995 & ⋯ & 2.5788 & 1.2502 & 1.2122 & 0.2189 & -0.3260 & -0.4259 & -0.4624 & 1.4268 & -1.4473 & 2.8440\\\\\n",
"\t3315 & -0.22889999 & -1.1686 & 1.73409986 & 0.21175002 & -3.493849993 & 0.21799627 & -0.32495001 & -2.3188000 & -0.12619999 & -0.08780000 & ⋯ & 0.0000 & -0.5599 & -0.7747 & 0.9959 & -0.9554 & -0.6129 & 2.3237 & -0.7365 & -0.4083 & -3.0874\\\\\n",
"\t5289 & 0.04359999 & 3.6465 & 3.03125000 & 0.90630001 & 0.187049985 & 3.19396544 & -0.23465000 & 1.0276000 & -0.56045002 & -0.05330001 & ⋯ & 0.8281 & -0.9206 & 0.6822 & -0.9480 & -0.2322 & -1.1048 & 0.8300 & 0.4654 & -0.5206 & 0.6745\\\\\n",
"\t868 & 0.10220000 & 0.8592 & 1.81244993 & -0.25509998 & 0.549250007 & -0.19470868 & -0.59965003 & 0.4235500 & -0.48370001 & -1.28314996 & ⋯ & 0.1421 & 0.7650 & 0.4446 & 0.2584 & 0.1067 & 0.5922 & 1.3067 & -0.8527 & -0.3135 & 0.8328\\\\\n",
"\t1677 & -0.20805000 & 0.7930 & 1.97329998 & 0.54895002 & -0.111049995 & 1.75220299 & -0.52419996 & 0.9599000 & -0.76335001 & -0.10170000 & ⋯ & 0.3969 & 0.9042 & 0.0418 & 0.4508 & 0.3277 & 4.0569 & -3.5420 & -0.8606 & -0.0633 & 2.4948\\\\\n",
"\t7043 & -0.27850002 & 2.4205 & 0.82440001 & -0.50725001 & 1.212399960 & -0.33966029 & -0.46219999 & 0.2445500 & -0.48930001 & 0.63644999 & ⋯ & 0.0147 & 1.1314 & 1.5184 & 1.1396 & -0.7535 & -0.1550 & -0.5552 & 0.9483 & 0.5121 & 0.9929\\\\\n",
"\t5613 & -0.66865003 & 0.5340 & 3.83539987 & 0.60944998 & -1.195199966 & 1.74077058 & -0.14775001 & -0.1435000 & 0.24705002 & 0.45889997 & ⋯ & 0.0717 & 0.5023 & 0.3477 & -2.3664 & -0.3586 & -0.3032 & -0.4723 & -0.3586 & -0.7751 & 1.1149\\\\\n",
"\t⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋱ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮\\\\\n",
"\t54552 & -0.547550023 & 0.5666 & 0.74390000 & -0.32515001 & 1.286950111 & 0.6714719 & -0.372799993 & 1.4985501 & -0.04715000 & -0.15339999 & ⋯ & 1.8504 & -0.2516 & 1.3114 & -0.1993 & -1.4090 & -0.4407 & -2.0924 & 0.6877 & 0.7649 & -0.1186\\\\\n",
"\t54920 & -0.190850005 & 2.6847 & 0.61905003 & 0.51645005 & -0.408650011 & 1.7125645 & -0.076900005 & -0.5360000 & -1.17120004 & 0.30594999 & ⋯ & 0.4583 & 0.8514 & 0.3027 & 1.4400 & -1.0779 & -0.6745 & 0.0638 & 0.4723 & 0.0850 & 0.7503\\\\\n",
"\t11178 & -0.007799983 & 1.4589 & 0.63424999 & -0.62494999 & 0.307300001 & -0.3424515 & -0.897199988 & 0.0240500 & -0.16354999 & 0.00515002 & ⋯ & -1.7519 & 0.3908 & -1.0155 & -0.2487 & -0.6887 & -0.6171 & -0.5462 & -0.1172 & -1.4105 & 0.1631\\\\\n",
"\t93643 & -0.781599998 & 0.9777 & 2.61190009 & 0.64004999 & 0.713050008 & 0.9237132 & 0.206200004 & 0.4028500 & 0.18150002 & -1.33759999 & ⋯ & 2.1395 & -0.4617 & 1.2257 & 0.0263 & -1.3893 & -1.9883 & 0.7824 & 0.2161 & -0.5916 & 2.0450\\\\\n",
"\t112869 & -0.174050003 & 0.1336 & -0.16070001 & 0.83440006 & 0.434750021 & 0.5052795 & 0.133000001 & -0.2637000 & -0.80325001 & -0.37760001 & ⋯ & 2.3786 & 1.1703 & 1.1386 & 0.7210 & -0.1182 & -0.0510 & -1.0956 & 0.8456 & -0.5989 & 1.1402\\\\\n",
"\t51147 & -0.131500006 & 2.5702 & 2.79585004 & 0.60960001 & 1.184949994 & 0.1883786 & -0.194200009 & 0.8002999 & -0.16949999 & 0.07554999 & ⋯ & 1.9107 & 1.5612 & 0.3518 & 1.2840 & -1.4728 & -0.3504 & 0.0130 & 0.4459 & -0.4840 & 0.9162\\\\\n",
"\t196403 & -0.179949999 & 3.3629 & 2.99699998 & 1.06465006 & 0.325349987 & 1.2875153 & -0.328400016 & 1.8518502 & -0.13325000 & -1.07975006 & ⋯ & 1.4798 & 0.1850 & 1.3844 & 0.3240 & -0.4564 & 0.3414 & 0.1307 & 0.2026 & -1.4586 & 1.7090\\\\\n",
"\t389677 & -0.299800009 & -1.7546 & 1.62085009 & 0.17885001 & 0.346049994 & 2.1395676 & 0.425999999 & 0.2757500 & -0.60355002 & -0.66229999 & ⋯ & 0.6175 & -0.6872 & 1.1080 & -0.3949 & -0.7650 & 0.6032 & -0.5789 & 0.8575 & 1.2912 & -0.5854\\\\\n",
"\t1296 & -0.568499982 & 4.0283 & 1.80404997 & 0.68540001 & 1.193750024 & -0.3998278 & -0.204600006 & 2.2550499 & 0.10470000 & 0.11945000 & ⋯ & 0.9755 & 0.6923 & -0.1845 & 0.1797 & -0.0929 & 0.0885 & 0.6156 & 0.2872 & -0.6606 & 0.7912\\\\\n",
"\t85352 & -0.582249999 & 2.8892 & 2.65304995 & 0.62145001 & 0.426599979 & 1.1645755 & 0.086000010 & 1.2165500 & 0.69494998 & -0.19315001 & ⋯ & -0.0009 & 3.7638 & 1.6589 & 0.1591 & -0.6720 & -1.0518 & -1.5408 & -0.1605 & 0.1139 & 2.4243\\\\\n",
"\t57610 & 0.498400003 & 5.1220 & 2.16345000 & 0.01574999 & 0.200550005 & 0.1731201 & -0.926600039 & 0.0807500 & -0.57225001 & 0.07119998 & ⋯ & 1.5447 & -0.0599 & 1.6722 & 0.2858 & 1.6272 & -0.8244 & 0.9907 & 0.4710 & 0.1368 & 1.4276\\\\\n",
"\t27147 & -0.202250004 & 2.5838 & 1.67175007 & -0.22469999 & 1.058600068 & 0.6260329 & -0.410300016 & 0.1346500 & -0.54540002 & -0.01105000 & ⋯ & 1.3721 & -0.4534 & -0.3415 & 0.3251 & -1.3887 & 0.4315 & 0.1750 & -0.6396 & -1.0847 & 1.3937\\\\\n",
"\t79591 & 1.026950002 & 2.7480 & -0.06799999 & 0.64854997 & 1.501299977 & 1.2647009 & 0.523100019 & -0.0559500 & 0.24710000 & 0.37870002 & ⋯ & 2.1479 & 1.1361 & -0.7604 & 1.6378 & -0.0226 & 0.0510 & -0.0003 & -0.4592 & 0.8158 & 1.6554\\\\\n",
"\t92595 & 0.652800024 & -0.7214 & 0.21370000 & 0.66485000 & 1.284350038 & 0.5647974 & 0.559400022 & 1.5563999 & 0.02030000 & -0.36090001 & ⋯ & 0.3339 & 1.3473 & 0.0010 & 0.0615 & -0.2524 & 0.0479 & -0.3532 & -0.2950 & 0.0858 & 0.1184\\\\\n",
"\t51063 & 0.343500018 & -0.8015 & 0.33515000 & 1.91869998 & 0.368699998 & 0.5586674 & -0.298150003 & 0.2594000 & 0.28309998 & 0.09540004 & ⋯ & 0.9597 & 1.8933 & 1.1444 & 0.9759 & -0.1300 & -0.5763 & -0.3481 & -1.0736 & -0.0896 & 1.2923\\\\\n",
"\t55223 & -0.215350002 & 4.3713 & 1.97140002 & 0.29425001 & 1.258400083 & 0.8483824 & 0.505299985 & 0.4320000 & -0.73879999 & -1.00734997 & ⋯ & -0.7425 & 1.5926 & 0.3204 & 0.3486 & -1.2565 & -0.0055 & -0.3076 & -0.5895 & -0.6759 & 1.1372\\\\\n",
"\t80022 & -0.499350011 & 3.3540 & 2.46420002 & 0.21785000 & -0.007000007 & 1.1016043 & 0.208849996 & -0.3577000 & -0.80614996 & 0.93999994 & ⋯ & 1.0909 & 0.1379 & 0.6538 & 0.9385 & -0.8598 & -0.1190 & -1.1109 & 0.0832 & -0.2971 & 0.8936\\\\\n",
"\t55589 & 0.989849985 & -1.7614 & -0.52405000 & -0.53944999 & 2.766950130 & -1.4092908 & 0.037900001 & 0.5296500 & 0.20385003 & -0.57599998 & ⋯ & -1.7398 & 1.1566 & -0.5645 & 1.4264 & 1.8400 & -0.1273 & 1.2060 & 0.2184 & 1.3779 & -0.5626\\\\\n",
"\t376267 & -0.697149992 & 1.8690 & 0.45809996 & -0.03180003 & 1.338700056 & -0.2823215 & -0.157900006 & 1.0916001 & -0.20415001 & -0.42180002 & ⋯ & 0.1199 & 1.2685 & 0.9052 & 0.0267 & 0.0809 & -1.1636 & 0.2976 & 1.9446 & -0.9014 & 1.8036\\\\\n",
"\t84820 & -0.152749985 & 1.8001 & 1.37894988 & 0.01440001 & 1.192999959 & 1.6359860 & -0.251900017 & 1.5041499 & -0.12639999 & -0.49724999 & ⋯ & 1.1424 & -0.0597 & 0.7671 & 0.5935 & -0.5742 & -1.0844 & -0.5707 & 2.0601 & -0.2694 & 1.1255\\\\\n",
"\t2931 & -0.489800006 & 4.3996 & 2.27640009 & 0.27145001 & -0.035150021 & 0.5720488 & -0.576700032 & 0.1173000 & -0.68005002 & 0.33640003 & ⋯ & 0.2727 & 0.5013 & 0.8471 & 0.2688 & 0.7681 & -0.5762 & -0.8154 & -0.0992 & -0.7370 & 1.7226\\\\\n",
"\t63876 & -0.252000004 & 2.4605 & 1.21990001 & -0.08165000 & 1.008049965 & 0.7371939 & -0.005400002 & 0.2307501 & -0.44770002 & -0.46705002 & ⋯ & -0.7579 & -0.6265 & 0.8404 & -0.2692 & 0.8911 & -0.2046 & -0.8071 & -0.1506 & -1.6715 & 0.9172\\\\\n",
"\t51275 & -0.829549968 & 2.4557 & 2.40814996 & 0.42320001 & -0.335050017 & -0.9146695 & 0.963299990 & 1.4400499 & 0.39770001 & 0.27579999 & ⋯ & 0.3883 & 0.6793 & 0.3237 & -0.4276 & 0.7665 & 0.5685 & -1.0498 & 1.5715 & -1.7042 & -0.0870\\\\\n",
"\t158747 & -0.933599949 & 2.2661 & 2.48624992 & 1.50850010 & -1.788749933 & -0.1306736 & -0.646350026 & -1.1307499 & 0.18900004 & 1.36570001 & ⋯ & 2.4502 & 1.9125 & 0.2526 & 0.5455 & 0.1402 & -0.9180 & -1.9362 & 1.3076 & -0.5795 & 0.3890\\\\\n",
"\t283232 & -0.549999952 & 1.0838 & 0.41525000 & -0.09474999 & 1.855700016 & -0.2727659 & -0.094699994 & 1.7906501 & -0.75310004 & 0.58985001 & ⋯ & 0.3257 & 1.1194 & 0.5754 & -0.4345 & -3.3375 & 0.5196 & -1.5637 & 1.1416 & 0.2517 & -0.1119\\\\\n",
"\t25960 & 0.060000002 & 1.8776 & 0.34240001 & -0.22815000 & 1.623250008 & -0.5708635 & 0.072649986 & 0.1602500 & 0.26474997 & 0.05900000 & ⋯ & 0.8320 & -0.3680 & 0.6608 & -0.2463 & -2.4105 & 0.1107 & -0.2676 & 0.6119 & 1.1775 & 0.9155\\\\\n",
"\t6376 & -0.391449988 & 2.0942 & 1.54129994 & 0.29714999 & -0.322299987 & 0.6695740 & 0.684000015 & -0.2364000 & -0.22969997 & -1.19679999 & ⋯ & 1.1901 & -0.0144 & 1.5630 & 0.3335 & 1.0411 & -1.1291 & 0.6466 & 1.4029 & -1.0273 & 0.0192\\\\\n",
"\t11033 & -0.816999972 & 0.0360 & 1.86659992 & 1.18130004 & -1.078150034 & 2.5671935 & -0.160849988 & 0.1246000 & 1.15509999 & 0.12650001 & ⋯ & 1.2484 & -0.1491 & 0.0777 & 0.3478 & -0.7770 & -0.2837 & -0.0944 & 0.7815 & -0.3094 & 2.2588\\\\\n",
"\t54869 & -0.491949975 & 3.9373 & 2.89374995 & 0.08510001 & -1.110100031 & 1.1950539 & -0.178350002 & 1.4240000 & -0.01594999 & 1.36944997 & ⋯ & -0.1743 & 1.0657 & 0.7791 & 1.0932 & -0.5247 & -0.5104 & -0.2863 & -0.5035 & 1.2087 & 2.5072\\\\\n",
"\t60 & -0.487500012 & -0.0225 & -0.53219998 & -0.72780001 & -0.636449993 & -0.1309013 & -0.509249985 & -0.4348000 & 0.53165001 & 0.25479999 & ⋯ & -1.4556 & -0.2475 & -0.6307 & -0.2042 & 0.7773 & 0.3077 & 1.8114 & -1.0285 & 0.0535 & -1.3198\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A matrix: 12328 × 45956 of type dbl\n",
"\n",
"| <!--/--> | BRD-A03772856__CD34__trt_cp | trichostatin-a__CD34__trt_cp | geldanamycin__CD34__trt_cp | KUC107191N__CD34__trt_cp | BRD-A35207501__CD34__trt_cp | iloprost__CD34__trt_cp | BRD-A72498772__CD34__trt_cp | BRD-A72796238__CD34__trt_cp | BRD-A73513677__CD34__trt_cp | BRD-A73558769__CD34__trt_cp | ⋯ | MW-MITF24__MCF7__trt_cp | l-buthionine-sulfoximine__PC3__trt_cp | alpha-tocopherol__PC3__trt_cp | cisplatin__PC3__trt_cp | iniparib__PC3__trt_cp | JMW-MITF1__PC3__trt_cp | bortezomib__PC3__trt_cp | selumetinib__PC3__trt_cp | glutamine__PC3__trt_cp | MW-MITF24__PC3__trt_cp |\n",
"|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
"| 5720 | 0.36540002 | -1.9333 | -1.78014994 | -0.61925000 | -0.729250073 | -2.01719809 | 0.18455000 | -1.1793000 | 0.34680000 | 0.10225001 | ⋯ | -2.1606 | -0.2913 | -1.2731 | -0.5659 | 0.4571 | 0.0308 | -0.2913 | -0.9489 | -1.0550 | -1.9929 |\n",
"| 466 | 0.69385004 | -4.0653 | -2.45910001 | 0.05739999 | 1.069949985 | -1.52120280 | -0.19575000 | 1.3569000 | 0.32670000 | 0.36719999 | ⋯ | -1.9576 | -0.6859 | 0.5907 | -0.2468 | 0.7582 | 0.4957 | -1.0830 | 0.3153 | 1.3292 | -0.5015 |\n",
"| 6009 | 0.55435002 | 0.1850 | 0.22250000 | 0.05124998 | 0.336199999 | -1.32433784 | 0.78560001 | -0.2471000 | 1.50240004 | -0.47415000 | ⋯ | -1.9373 | -0.7577 | -1.8149 | 0.0000 | 0.3941 | -1.6190 | 0.1462 | -2.1747 | -0.2952 | -2.1053 |\n",
"| 2309 | -0.31579998 | 2.2660 | 0.67035002 | -0.39039999 | 1.141200066 | 0.91430640 | 0.45165002 | 0.1099000 | -0.58609998 | -1.34329998 | ⋯ | 0.9808 | -0.0848 | -1.5376 | 0.6194 | -0.2978 | 0.5139 | 2.9324 | -0.9933 | -0.0140 | -1.1789 |\n",
"| 387 | 0.37180001 | -0.2558 | -2.59875011 | -2.12490010 | 1.495700002 | -3.34633827 | -0.03835000 | -0.9017001 | 1.18655002 | 0.68274999 | ⋯ | -1.5168 | 0.0997 | -0.3862 | 0.1973 | -0.4246 | -0.5682 | 0.6157 | -0.3696 | 0.3436 | -3.2787 |\n",
"| 3553 | 0.70824999 | -0.5149 | -0.73619998 | -0.41515002 | 1.960999966 | 0.22129090 | -0.20070001 | 0.8321000 | 2.93820000 | -0.08945002 | ⋯ | 3.2767 | 0.0000 | -0.1367 | -0.6745 | -1.0342 | -1.3800 | -0.9713 | 1.2338 | -1.3174 | -0.6564 |\n",
"| 427 | 0.18295000 | -1.6045 | 0.42860001 | 0.30954999 | 1.228850007 | 0.06338993 | 0.44700000 | 0.3969500 | 0.57410002 | -0.11010003 | ⋯ | 0.5427 | -0.5669 | -0.7753 | -0.8029 | 1.6375 | 1.7251 | 1.2290 | 0.0243 | -0.7690 | -0.6058 |\n",
"| 5898 | -0.40434998 | 3.5042 | 2.97979999 | -0.84810001 | 1.905500054 | 0.31654096 | -0.01730000 | -0.1905500 | -0.82900000 | -0.52789998 | ⋯ | -0.3057 | 0.1609 | 0.2776 | 0.0750 | -2.8649 | 0.5809 | 1.7948 | -0.0093 | 1.2902 | 0.2903 |\n",
"| 23365 | 0.49500000 | 0.4630 | 0.48894998 | -0.25070000 | 0.521200001 | -0.62915254 | -0.67110002 | -0.7869500 | 0.49564999 | 1.38380003 | ⋯ | -0.7719 | -0.3665 | 0.7769 | 0.3405 | -0.6687 | 0.4276 | -2.5250 | 0.0963 | 0.0482 | 0.0963 |\n",
"| 6657 | -0.58120000 | 2.3181 | 1.18390000 | 0.32394999 | 0.963199973 | 1.12940836 | -0.09670001 | 1.5269001 | -0.28994998 | -0.26674998 | ⋯ | 2.3400 | 0.8720 | 1.4368 | 0.5604 | -1.3073 | -0.8898 | -0.4415 | 0.7747 | -0.3321 | 2.5004 |\n",
"| 5054 | -0.25055000 | -0.2075 | -0.43175000 | 0.16700003 | 1.369400024 | 1.35352969 | -0.11345001 | 0.5116500 | -0.07969996 | -0.21934998 | ⋯ | 0.6593 | 0.2299 | 0.5751 | 0.2370 | 0.4596 | 0.3050 | -1.6550 | 0.0137 | 0.4267 | 0.6745 |\n",
"| 3108 | -0.06060000 | -1.8116 | -1.61284995 | -0.08275000 | -0.534399986 | -0.13355637 | -0.01085000 | -1.5620000 | 0.59775001 | 0.97039998 | ⋯ | 0.6745 | 0.3049 | -0.5842 | -0.3346 | 1.3939 | -0.4618 | 0.4915 | 0.0590 | 0.1180 | 1.7550 |\n",
"| 1950 | 0.34324998 | -0.3875 | 1.33039999 | 0.69085002 | -1.051300049 | 3.66408134 | 0.38674998 | 2.6680501 | -0.73095000 | -0.51055002 | ⋯ | 0.8943 | 0.2505 | 1.1675 | -0.0811 | -0.4084 | -0.6610 | -0.0670 | 1.3110 | -1.1154 | 2.5754 |\n",
"| 351 | -0.75015002 | 0.0000 | 1.67859995 | 0.01835000 | 0.958649993 | 0.42959470 | 0.31160000 | 0.9131501 | 0.33724999 | -0.51849997 | ⋯ | 1.2067 | 0.8746 | -1.4754 | 0.3245 | 1.2609 | 0.4734 | 1.3987 | -0.1130 | -0.8090 | 0.3988 |\n",
"| 4846 | 0.44309998 | 2.6904 | 1.82799995 | 0.63379997 | 0.361950010 | 1.81054175 | 0.38900000 | 3.5537500 | -0.76929998 | -0.95864999 | ⋯ | -1.2723 | 1.0611 | 0.0000 | 0.8742 | 0.5819 | 0.4788 | 1.4877 | -0.3579 | -0.6335 | -0.7591 |\n",
"| 1452 | 0.05585000 | -0.3123 | 0.57295001 | -0.44580001 | 0.636549950 | -0.72561306 | -3.03379989 | -0.7344500 | 0.70099998 | 0.10130000 | ⋯ | -1.9790 | 0.3489 | -0.7107 | -1.8170 | 0.3777 | -1.1747 | 1.5557 | -0.0845 | -1.1233 | -1.5332 |\n",
"| 4776 | -0.92770004 | 0.6834 | 2.35645008 | 1.05629992 | -0.044949993 | 0.66652113 | -0.03335000 | 2.2428999 | 0.25165001 | 0.55704999 | ⋯ | 3.3373 | 0.5311 | 1.3320 | 0.3057 | -0.9554 | -0.9277 | -1.0772 | 0.3361 | -0.9042 | 3.1649 |\n",
"| 6908 | 0.20305002 | 1.6617 | -0.03129999 | 0.27434999 | 0.650349975 | -0.19393554 | -0.39605001 | 0.2097500 | 0.72994995 | 0.24660000 | ⋯ | -2.6201 | 0.3546 | -0.8340 | 0.1707 | 0.7447 | 0.8058 | -0.3623 | -1.9207 | 0.1919 | -1.5016 |\n",
"| 672 | 0.32475001 | -4.0764 | -3.70605016 | 0.08045001 | -0.453600019 | -0.40477309 | 0.57854998 | 0.4603500 | -0.35640001 | -0.57574999 | ⋯ | -0.0347 | 0.5236 | -1.3417 | 0.5860 | 0.7067 | -0.6479 | 2.8601 | 2.8988 | -0.1277 | 0.1526 |\n",
"| 5710 | 0.63964999 | 0.2391 | 0.23535000 | -1.49465001 | -1.058050036 | -1.23082113 | 0.30835003 | -1.5607500 | -1.05330002 | 1.03775001 | ⋯ | -0.8548 | 0.0244 | -0.4195 | 0.8007 | 0.8163 | -0.6469 | 2.6838 | -0.4705 | -1.5872 | -1.9920 |\n",
"| 2115 | -0.46765000 | 2.5311 | 0.92490000 | 0.27040002 | -0.008450001 | 1.54992425 | 0.02805001 | 0.9752501 | -0.80159998 | -0.07155001 | ⋯ | 1.7185 | 0.0407 | 0.8669 | -2.4175 | -1.3462 | 0.1283 | -0.6444 | 0.9818 | -0.0399 | 0.1548 |\n",
"| 7015 | -0.62810004 | 2.9025 | 1.92159998 | 0.28770000 | 0.454999983 | 1.53958702 | 0.56625003 | 0.9501500 | -0.29589999 | -0.62774998 | ⋯ | 1.2487 | 0.5907 | 0.8714 | 0.6421 | -0.9362 | -0.4963 | -0.4187 | 0.6203 | -0.1979 | 3.4552 |\n",
"| 8726 | 0.46415001 | -3.4828 | -2.23075008 | 0.99154997 | 0.230650008 | 0.27298701 | 0.02245000 | -0.7093000 | -0.07795000 | -0.39450002 | ⋯ | -1.6259 | -0.1834 | -0.9279 | -5.2129 | -0.4035 | 0.8041 | 1.4548 | 1.4854 | 1.7362 | 1.4854 |\n",
"| 2185 | -0.59829998 | -2.5377 | 4.76999998 | -0.27070001 | -2.783349991 | 1.25042439 | -0.24249998 | -3.3810499 | -0.36440000 | 0.63944995 | ⋯ | 2.5788 | 1.2502 | 1.2122 | 0.2189 | -0.3260 | -0.4259 | -0.4624 | 1.4268 | -1.4473 | 2.8440 |\n",
"| 3315 | -0.22889999 | -1.1686 | 1.73409986 | 0.21175002 | -3.493849993 | 0.21799627 | -0.32495001 | -2.3188000 | -0.12619999 | -0.08780000 | ⋯ | 0.0000 | -0.5599 | -0.7747 | 0.9959 | -0.9554 | -0.6129 | 2.3237 | -0.7365 | -0.4083 | -3.0874 |\n",
"| 5289 | 0.04359999 | 3.6465 | 3.03125000 | 0.90630001 | 0.187049985 | 3.19396544 | -0.23465000 | 1.0276000 | -0.56045002 | -0.05330001 | ⋯ | 0.8281 | -0.9206 | 0.6822 | -0.9480 | -0.2322 | -1.1048 | 0.8300 | 0.4654 | -0.5206 | 0.6745 |\n",
"| 868 | 0.10220000 | 0.8592 | 1.81244993 | -0.25509998 | 0.549250007 | -0.19470868 | -0.59965003 | 0.4235500 | -0.48370001 | -1.28314996 | ⋯ | 0.1421 | 0.7650 | 0.4446 | 0.2584 | 0.1067 | 0.5922 | 1.3067 | -0.8527 | -0.3135 | 0.8328 |\n",
"| 1677 | -0.20805000 | 0.7930 | 1.97329998 | 0.54895002 | -0.111049995 | 1.75220299 | -0.52419996 | 0.9599000 | -0.76335001 | -0.10170000 | ⋯ | 0.3969 | 0.9042 | 0.0418 | 0.4508 | 0.3277 | 4.0569 | -3.5420 | -0.8606 | -0.0633 | 2.4948 |\n",
"| 7043 | -0.27850002 | 2.4205 | 0.82440001 | -0.50725001 | 1.212399960 | -0.33966029 | -0.46219999 | 0.2445500 | -0.48930001 | 0.63644999 | ⋯ | 0.0147 | 1.1314 | 1.5184 | 1.1396 | -0.7535 | -0.1550 | -0.5552 | 0.9483 | 0.5121 | 0.9929 |\n",
"| 5613 | -0.66865003 | 0.5340 | 3.83539987 | 0.60944998 | -1.195199966 | 1.74077058 | -0.14775001 | -0.1435000 | 0.24705002 | 0.45889997 | ⋯ | 0.0717 | 0.5023 | 0.3477 | -2.3664 | -0.3586 | -0.3032 | -0.4723 | -0.3586 | -0.7751 | 1.1149 |\n",
"| ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋱ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ |\n",
"| 54552 | -0.547550023 | 0.5666 | 0.74390000 | -0.32515001 | 1.286950111 | 0.6714719 | -0.372799993 | 1.4985501 | -0.04715000 | -0.15339999 | ⋯ | 1.8504 | -0.2516 | 1.3114 | -0.1993 | -1.4090 | -0.4407 | -2.0924 | 0.6877 | 0.7649 | -0.1186 |\n",
"| 54920 | -0.190850005 | 2.6847 | 0.61905003 | 0.51645005 | -0.408650011 | 1.7125645 | -0.076900005 | -0.5360000 | -1.17120004 | 0.30594999 | ⋯ | 0.4583 | 0.8514 | 0.3027 | 1.4400 | -1.0779 | -0.6745 | 0.0638 | 0.4723 | 0.0850 | 0.7503 |\n",
"| 11178 | -0.007799983 | 1.4589 | 0.63424999 | -0.62494999 | 0.307300001 | -0.3424515 | -0.897199988 | 0.0240500 | -0.16354999 | 0.00515002 | ⋯ | -1.7519 | 0.3908 | -1.0155 | -0.2487 | -0.6887 | -0.6171 | -0.5462 | -0.1172 | -1.4105 | 0.1631 |\n",
"| 93643 | -0.781599998 | 0.9777 | 2.61190009 | 0.64004999 | 0.713050008 | 0.9237132 | 0.206200004 | 0.4028500 | 0.18150002 | -1.33759999 | ⋯ | 2.1395 | -0.4617 | 1.2257 | 0.0263 | -1.3893 | -1.9883 | 0.7824 | 0.2161 | -0.5916 | 2.0450 |\n",
"| 112869 | -0.174050003 | 0.1336 | -0.16070001 | 0.83440006 | 0.434750021 | 0.5052795 | 0.133000001 | -0.2637000 | -0.80325001 | -0.37760001 | ⋯ | 2.3786 | 1.1703 | 1.1386 | 0.7210 | -0.1182 | -0.0510 | -1.0956 | 0.8456 | -0.5989 | 1.1402 |\n",
"| 51147 | -0.131500006 | 2.5702 | 2.79585004 | 0.60960001 | 1.184949994 | 0.1883786 | -0.194200009 | 0.8002999 | -0.16949999 | 0.07554999 | ⋯ | 1.9107 | 1.5612 | 0.3518 | 1.2840 | -1.4728 | -0.3504 | 0.0130 | 0.4459 | -0.4840 | 0.9162 |\n",
"| 196403 | -0.179949999 | 3.3629 | 2.99699998 | 1.06465006 | 0.325349987 | 1.2875153 | -0.328400016 | 1.8518502 | -0.13325000 | -1.07975006 | ⋯ | 1.4798 | 0.1850 | 1.3844 | 0.3240 | -0.4564 | 0.3414 | 0.1307 | 0.2026 | -1.4586 | 1.7090 |\n",
"| 389677 | -0.299800009 | -1.7546 | 1.62085009 | 0.17885001 | 0.346049994 | 2.1395676 | 0.425999999 | 0.2757500 | -0.60355002 | -0.66229999 | ⋯ | 0.6175 | -0.6872 | 1.1080 | -0.3949 | -0.7650 | 0.6032 | -0.5789 | 0.8575 | 1.2912 | -0.5854 |\n",
"| 1296 | -0.568499982 | 4.0283 | 1.80404997 | 0.68540001 | 1.193750024 | -0.3998278 | -0.204600006 | 2.2550499 | 0.10470000 | 0.11945000 | ⋯ | 0.9755 | 0.6923 | -0.1845 | 0.1797 | -0.0929 | 0.0885 | 0.6156 | 0.2872 | -0.6606 | 0.7912 |\n",
"| 85352 | -0.582249999 | 2.8892 | 2.65304995 | 0.62145001 | 0.426599979 | 1.1645755 | 0.086000010 | 1.2165500 | 0.69494998 | -0.19315001 | ⋯ | -0.0009 | 3.7638 | 1.6589 | 0.1591 | -0.6720 | -1.0518 | -1.5408 | -0.1605 | 0.1139 | 2.4243 |\n",
"| 57610 | 0.498400003 | 5.1220 | 2.16345000 | 0.01574999 | 0.200550005 | 0.1731201 | -0.926600039 | 0.0807500 | -0.57225001 | 0.07119998 | ⋯ | 1.5447 | -0.0599 | 1.6722 | 0.2858 | 1.6272 | -0.8244 | 0.9907 | 0.4710 | 0.1368 | 1.4276 |\n",
"| 27147 | -0.202250004 | 2.5838 | 1.67175007 | -0.22469999 | 1.058600068 | 0.6260329 | -0.410300016 | 0.1346500 | -0.54540002 | -0.01105000 | ⋯ | 1.3721 | -0.4534 | -0.3415 | 0.3251 | -1.3887 | 0.4315 | 0.1750 | -0.6396 | -1.0847 | 1.3937 |\n",
"| 79591 | 1.026950002 | 2.7480 | -0.06799999 | 0.64854997 | 1.501299977 | 1.2647009 | 0.523100019 | -0.0559500 | 0.24710000 | 0.37870002 | ⋯ | 2.1479 | 1.1361 | -0.7604 | 1.6378 | -0.0226 | 0.0510 | -0.0003 | -0.4592 | 0.8158 | 1.6554 |\n",
"| 92595 | 0.652800024 | -0.7214 | 0.21370000 | 0.66485000 | 1.284350038 | 0.5647974 | 0.559400022 | 1.5563999 | 0.02030000 | -0.36090001 | ⋯ | 0.3339 | 1.3473 | 0.0010 | 0.0615 | -0.2524 | 0.0479 | -0.3532 | -0.2950 | 0.0858 | 0.1184 |\n",
"| 51063 | 0.343500018 | -0.8015 | 0.33515000 | 1.91869998 | 0.368699998 | 0.5586674 | -0.298150003 | 0.2594000 | 0.28309998 | 0.09540004 | ⋯ | 0.9597 | 1.8933 | 1.1444 | 0.9759 | -0.1300 | -0.5763 | -0.3481 | -1.0736 | -0.0896 | 1.2923 |\n",
"| 55223 | -0.215350002 | 4.3713 | 1.97140002 | 0.29425001 | 1.258400083 | 0.8483824 | 0.505299985 | 0.4320000 | -0.73879999 | -1.00734997 | ⋯ | -0.7425 | 1.5926 | 0.3204 | 0.3486 | -1.2565 | -0.0055 | -0.3076 | -0.5895 | -0.6759 | 1.1372 |\n",
"| 80022 | -0.499350011 | 3.3540 | 2.46420002 | 0.21785000 | -0.007000007 | 1.1016043 | 0.208849996 | -0.3577000 | -0.80614996 | 0.93999994 | ⋯ | 1.0909 | 0.1379 | 0.6538 | 0.9385 | -0.8598 | -0.1190 | -1.1109 | 0.0832 | -0.2971 | 0.8936 |\n",
"| 55589 | 0.989849985 | -1.7614 | -0.52405000 | -0.53944999 | 2.766950130 | -1.4092908 | 0.037900001 | 0.5296500 | 0.20385003 | -0.57599998 | ⋯ | -1.7398 | 1.1566 | -0.5645 | 1.4264 | 1.8400 | -0.1273 | 1.2060 | 0.2184 | 1.3779 | -0.5626 |\n",
"| 376267 | -0.697149992 | 1.8690 | 0.45809996 | -0.03180003 | 1.338700056 | -0.2823215 | -0.157900006 | 1.0916001 | -0.20415001 | -0.42180002 | ⋯ | 0.1199 | 1.2685 | 0.9052 | 0.0267 | 0.0809 | -1.1636 | 0.2976 | 1.9446 | -0.9014 | 1.8036 |\n",
"| 84820 | -0.152749985 | 1.8001 | 1.37894988 | 0.01440001 | 1.192999959 | 1.6359860 | -0.251900017 | 1.5041499 | -0.12639999 | -0.49724999 | ⋯ | 1.1424 | -0.0597 | 0.7671 | 0.5935 | -0.5742 | -1.0844 | -0.5707 | 2.0601 | -0.2694 | 1.1255 |\n",
"| 2931 | -0.489800006 | 4.3996 | 2.27640009 | 0.27145001 | -0.035150021 | 0.5720488 | -0.576700032 | 0.1173000 | -0.68005002 | 0.33640003 | ⋯ | 0.2727 | 0.5013 | 0.8471 | 0.2688 | 0.7681 | -0.5762 | -0.8154 | -0.0992 | -0.7370 | 1.7226 |\n",
"| 63876 | -0.252000004 | 2.4605 | 1.21990001 | -0.08165000 | 1.008049965 | 0.7371939 | -0.005400002 | 0.2307501 | -0.44770002 | -0.46705002 | ⋯ | -0.7579 | -0.6265 | 0.8404 | -0.2692 | 0.8911 | -0.2046 | -0.8071 | -0.1506 | -1.6715 | 0.9172 |\n",
"| 51275 | -0.829549968 | 2.4557 | 2.40814996 | 0.42320001 | -0.335050017 | -0.9146695 | 0.963299990 | 1.4400499 | 0.39770001 | 0.27579999 | ⋯ | 0.3883 | 0.6793 | 0.3237 | -0.4276 | 0.7665 | 0.5685 | -1.0498 | 1.5715 | -1.7042 | -0.0870 |\n",
"| 158747 | -0.933599949 | 2.2661 | 2.48624992 | 1.50850010 | -1.788749933 | -0.1306736 | -0.646350026 | -1.1307499 | 0.18900004 | 1.36570001 | ⋯ | 2.4502 | 1.9125 | 0.2526 | 0.5455 | 0.1402 | -0.9180 | -1.9362 | 1.3076 | -0.5795 | 0.3890 |\n",
"| 283232 | -0.549999952 | 1.0838 | 0.41525000 | -0.09474999 | 1.855700016 | -0.2727659 | -0.094699994 | 1.7906501 | -0.75310004 | 0.58985001 | ⋯ | 0.3257 | 1.1194 | 0.5754 | -0.4345 | -3.3375 | 0.5196 | -1.5637 | 1.1416 | 0.2517 | -0.1119 |\n",
"| 25960 | 0.060000002 | 1.8776 | 0.34240001 | -0.22815000 | 1.623250008 | -0.5708635 | 0.072649986 | 0.1602500 | 0.26474997 | 0.05900000 | ⋯ | 0.8320 | -0.3680 | 0.6608 | -0.2463 | -2.4105 | 0.1107 | -0.2676 | 0.6119 | 1.1775 | 0.9155 |\n",
"| 6376 | -0.391449988 | 2.0942 | 1.54129994 | 0.29714999 | -0.322299987 | 0.6695740 | 0.684000015 | -0.2364000 | -0.22969997 | -1.19679999 | ⋯ | 1.1901 | -0.0144 | 1.5630 | 0.3335 | 1.0411 | -1.1291 | 0.6466 | 1.4029 | -1.0273 | 0.0192 |\n",
"| 11033 | -0.816999972 | 0.0360 | 1.86659992 | 1.18130004 | -1.078150034 | 2.5671935 | -0.160849988 | 0.1246000 | 1.15509999 | 0.12650001 | ⋯ | 1.2484 | -0.1491 | 0.0777 | 0.3478 | -0.7770 | -0.2837 | -0.0944 | 0.7815 | -0.3094 | 2.2588 |\n",
"| 54869 | -0.491949975 | 3.9373 | 2.89374995 | 0.08510001 | -1.110100031 | 1.1950539 | -0.178350002 | 1.4240000 | -0.01594999 | 1.36944997 | ⋯ | -0.1743 | 1.0657 | 0.7791 | 1.0932 | -0.5247 | -0.5104 | -0.2863 | -0.5035 | 1.2087 | 2.5072 |\n",
"| 60 | -0.487500012 | -0.0225 | -0.53219998 | -0.72780001 | -0.636449993 | -0.1309013 | -0.509249985 | -0.4348000 | 0.53165001 | 0.25479999 | ⋯ | -1.4556 | -0.2475 | -0.6307 | -0.2042 | 0.7773 | 0.3077 | 1.8114 | -1.0285 | 0.0535 | -1.3198 |\n",
"\n"
],
"text/plain": [
" BRD-A03772856__CD34__trt_cp trichostatin-a__CD34__trt_cp\n",
"5720 0.36540002 -1.9333 \n",
"466 0.69385004 -4.0653 \n",
"6009 0.55435002 0.1850 \n",
"2309 -0.31579998 2.2660 \n",
"387 0.37180001 -0.2558 \n",
"3553 0.70824999 -0.5149 \n",
"427 0.18295000 -1.6045 \n",
"5898 -0.40434998 3.5042 \n",
"23365 0.49500000 0.4630 \n",
"6657 -0.58120000 2.3181 \n",
"5054 -0.25055000 -0.2075 \n",
"3108 -0.06060000 -1.8116 \n",
"1950 0.34324998 -0.3875 \n",
"351 -0.75015002 0.0000 \n",
"4846 0.44309998 2.6904 \n",
"1452 0.05585000 -0.3123 \n",
"4776 -0.92770004 0.6834 \n",
"6908 0.20305002 1.6617 \n",
"672 0.32475001 -4.0764 \n",
"5710 0.63964999 0.2391 \n",
"2115 -0.46765000 2.5311 \n",
"7015 -0.62810004 2.9025 \n",
"8726 0.46415001 -3.4828 \n",
"2185 -0.59829998 -2.5377 \n",
"3315 -0.22889999 -1.1686 \n",
"5289 0.04359999 3.6465 \n",
"868 0.10220000 0.8592 \n",
"1677 -0.20805000 0.7930 \n",
"7043 -0.27850002 2.4205 \n",
"5613 -0.66865003 0.5340 \n",
"⋮ ⋮ ⋮ \n",
"54552 -0.547550023 0.5666 \n",
"54920 -0.190850005 2.6847 \n",
"11178 -0.007799983 1.4589 \n",
"93643 -0.781599998 0.9777 \n",
"112869 -0.174050003 0.1336 \n",
"51147 -0.131500006 2.5702 \n",
"196403 -0.179949999 3.3629 \n",
"389677 -0.299800009 -1.7546 \n",
"1296 -0.568499982 4.0283 \n",
"85352 -0.582249999 2.8892 \n",
"57610 0.498400003 5.1220 \n",
"27147 -0.202250004 2.5838 \n",
"79591 1.026950002 2.7480 \n",
"92595 0.652800024 -0.7214 \n",
"51063 0.343500018 -0.8015 \n",
"55223 -0.215350002 4.3713 \n",
"80022 -0.499350011 3.3540 \n",
"55589 0.989849985 -1.7614 \n",
"376267 -0.697149992 1.8690 \n",
"84820 -0.152749985 1.8001 \n",
"2931 -0.489800006 4.3996 \n",
"63876 -0.252000004 2.4605 \n",
"51275 -0.829549968 2.4557 \n",
"158747 -0.933599949 2.2661 \n",
"283232 -0.549999952 1.0838 \n",
"25960 0.060000002 1.8776 \n",
"6376 -0.391449988 2.0942 \n",
"11033 -0.816999972 0.0360 \n",
"54869 -0.491949975 3.9373 \n",
"60 -0.487500012 -0.0225 \n",
" geldanamycin__CD34__trt_cp KUC107191N__CD34__trt_cp\n",
"5720 -1.78014994 -0.61925000 \n",
"466 -2.45910001 0.05739999 \n",
"6009 0.22250000 0.05124998 \n",
"2309 0.67035002 -0.39039999 \n",
"387 -2.59875011 -2.12490010 \n",
"3553 -0.73619998 -0.41515002 \n",
"427 0.42860001 0.30954999 \n",
"5898 2.97979999 -0.84810001 \n",
"23365 0.48894998 -0.25070000 \n",
"6657 1.18390000 0.32394999 \n",
"5054 -0.43175000 0.16700003 \n",
"3108 -1.61284995 -0.08275000 \n",
"1950 1.33039999 0.69085002 \n",
"351 1.67859995 0.01835000 \n",
"4846 1.82799995 0.63379997 \n",
"1452 0.57295001 -0.44580001 \n",
"4776 2.35645008 1.05629992 \n",
"6908 -0.03129999 0.27434999 \n",
"672 -3.70605016 0.08045001 \n",
"5710 0.23535000 -1.49465001 \n",
"2115 0.92490000 0.27040002 \n",
"7015 1.92159998 0.28770000 \n",
"8726 -2.23075008 0.99154997 \n",
"2185 4.76999998 -0.27070001 \n",
"3315 1.73409986 0.21175002 \n",
"5289 3.03125000 0.90630001 \n",
"868 1.81244993 -0.25509998 \n",
"1677 1.97329998 0.54895002 \n",
"7043 0.82440001 -0.50725001 \n",
"5613 3.83539987 0.60944998 \n",
"⋮ ⋮ ⋮ \n",
"54552 0.74390000 -0.32515001 \n",
"54920 0.61905003 0.51645005 \n",
"11178 0.63424999 -0.62494999 \n",
"93643 2.61190009 0.64004999 \n",
"112869 -0.16070001 0.83440006 \n",
"51147 2.79585004 0.60960001 \n",
"196403 2.99699998 1.06465006 \n",
"389677 1.62085009 0.17885001 \n",
"1296 1.80404997 0.68540001 \n",
"85352 2.65304995 0.62145001 \n",
"57610 2.16345000 0.01574999 \n",
"27147 1.67175007 -0.22469999 \n",
"79591 -0.06799999 0.64854997 \n",
"92595 0.21370000 0.66485000 \n",
"51063 0.33515000 1.91869998 \n",
"55223 1.97140002 0.29425001 \n",
"80022 2.46420002 0.21785000 \n",
"55589 -0.52405000 -0.53944999 \n",
"376267 0.45809996 -0.03180003 \n",
"84820 1.37894988 0.01440001 \n",
"2931 2.27640009 0.27145001 \n",
"63876 1.21990001 -0.08165000 \n",
"51275 2.40814996 0.42320001 \n",
"158747 2.48624992 1.50850010 \n",
"283232 0.41525000 -0.09474999 \n",
"25960 0.34240001 -0.22815000 \n",
"6376 1.54129994 0.29714999 \n",
"11033 1.86659992 1.18130004 \n",
"54869 2.89374995 0.08510001 \n",
"60 -0.53219998 -0.72780001 \n",
" BRD-A35207501__CD34__trt_cp iloprost__CD34__trt_cp\n",
"5720 -0.729250073 -2.01719809 \n",
"466 1.069949985 -1.52120280 \n",
"6009 0.336199999 -1.32433784 \n",
"2309 1.141200066 0.91430640 \n",
"387 1.495700002 -3.34633827 \n",
"3553 1.960999966 0.22129090 \n",
"427 1.228850007 0.06338993 \n",
"5898 1.905500054 0.31654096 \n",
"23365 0.521200001 -0.62915254 \n",
"6657 0.963199973 1.12940836 \n",
"5054 1.369400024 1.35352969 \n",
"3108 -0.534399986 -0.13355637 \n",
"1950 -1.051300049 3.66408134 \n",
"351 0.958649993 0.42959470 \n",
"4846 0.361950010 1.81054175 \n",
"1452 0.636549950 -0.72561306 \n",
"4776 -0.044949993 0.66652113 \n",
"6908 0.650349975 -0.19393554 \n",
"672 -0.453600019 -0.40477309 \n",
"5710 -1.058050036 -1.23082113 \n",
"2115 -0.008450001 1.54992425 \n",
"7015 0.454999983 1.53958702 \n",
"8726 0.230650008 0.27298701 \n",
"2185 -2.783349991 1.25042439 \n",
"3315 -3.493849993 0.21799627 \n",
"5289 0.187049985 3.19396544 \n",
"868 0.549250007 -0.19470868 \n",
"1677 -0.111049995 1.75220299 \n",
"7043 1.212399960 -0.33966029 \n",
"5613 -1.195199966 1.74077058 \n",
"⋮ ⋮ ⋮ \n",
"54552 1.286950111 0.6714719 \n",
"54920 -0.408650011 1.7125645 \n",
"11178 0.307300001 -0.3424515 \n",
"93643 0.713050008 0.9237132 \n",
"112869 0.434750021 0.5052795 \n",
"51147 1.184949994 0.1883786 \n",
"196403 0.325349987 1.2875153 \n",
"389677 0.346049994 2.1395676 \n",
"1296 1.193750024 -0.3998278 \n",
"85352 0.426599979 1.1645755 \n",
"57610 0.200550005 0.1731201 \n",
"27147 1.058600068 0.6260329 \n",
"79591 1.501299977 1.2647009 \n",
"92595 1.284350038 0.5647974 \n",
"51063 0.368699998 0.5586674 \n",
"55223 1.258400083 0.8483824 \n",
"80022 -0.007000007 1.1016043 \n",
"55589 2.766950130 -1.4092908 \n",
"376267 1.338700056 -0.2823215 \n",
"84820 1.192999959 1.6359860 \n",
"2931 -0.035150021 0.5720488 \n",
"63876 1.008049965 0.7371939 \n",
"51275 -0.335050017 -0.9146695 \n",
"158747 -1.788749933 -0.1306736 \n",
"283232 1.855700016 -0.2727659 \n",
"25960 1.623250008 -0.5708635 \n",
"6376 -0.322299987 0.6695740 \n",
"11033 -1.078150034 2.5671935 \n",
"54869 -1.110100031 1.1950539 \n",
"60 -0.636449993 -0.1309013 \n",
" BRD-A72498772__CD34__trt_cp BRD-A72796238__CD34__trt_cp\n",
"5720 0.18455000 -1.1793000 \n",
"466 -0.19575000 1.3569000 \n",
"6009 0.78560001 -0.2471000 \n",
"2309 0.45165002 0.1099000 \n",
"387 -0.03835000 -0.9017001 \n",
"3553 -0.20070001 0.8321000 \n",
"427 0.44700000 0.3969500 \n",
"5898 -0.01730000 -0.1905500 \n",
"23365 -0.67110002 -0.7869500 \n",
"6657 -0.09670001 1.5269001 \n",
"5054 -0.11345001 0.5116500 \n",
"3108 -0.01085000 -1.5620000 \n",
"1950 0.38674998 2.6680501 \n",
"351 0.31160000 0.9131501 \n",
"4846 0.38900000 3.5537500 \n",
"1452 -3.03379989 -0.7344500 \n",
"4776 -0.03335000 2.2428999 \n",
"6908 -0.39605001 0.2097500 \n",
"672 0.57854998 0.4603500 \n",
"5710 0.30835003 -1.5607500 \n",
"2115 0.02805001 0.9752501 \n",
"7015 0.56625003 0.9501500 \n",
"8726 0.02245000 -0.7093000 \n",
"2185 -0.24249998 -3.3810499 \n",
"3315 -0.32495001 -2.3188000 \n",
"5289 -0.23465000 1.0276000 \n",
"868 -0.59965003 0.4235500 \n",
"1677 -0.52419996 0.9599000 \n",
"7043 -0.46219999 0.2445500 \n",
"5613 -0.14775001 -0.1435000 \n",
"⋮ ⋮ ⋮ \n",
"54552 -0.372799993 1.4985501 \n",
"54920 -0.076900005 -0.5360000 \n",
"11178 -0.897199988 0.0240500 \n",
"93643 0.206200004 0.4028500 \n",
"112869 0.133000001 -0.2637000 \n",
"51147 -0.194200009 0.8002999 \n",
"196403 -0.328400016 1.8518502 \n",
"389677 0.425999999 0.2757500 \n",
"1296 -0.204600006 2.2550499 \n",
"85352 0.086000010 1.2165500 \n",
"57610 -0.926600039 0.0807500 \n",
"27147 -0.410300016 0.1346500 \n",
"79591 0.523100019 -0.0559500 \n",
"92595 0.559400022 1.5563999 \n",
"51063 -0.298150003 0.2594000 \n",
"55223 0.505299985 0.4320000 \n",
"80022 0.208849996 -0.3577000 \n",
"55589 0.037900001 0.5296500 \n",
"376267 -0.157900006 1.0916001 \n",
"84820 -0.251900017 1.5041499 \n",
"2931 -0.576700032 0.1173000 \n",
"63876 -0.005400002 0.2307501 \n",
"51275 0.963299990 1.4400499 \n",
"158747 -0.646350026 -1.1307499 \n",
"283232 -0.094699994 1.7906501 \n",
"25960 0.072649986 0.1602500 \n",
"6376 0.684000015 -0.2364000 \n",
"11033 -0.160849988 0.1246000 \n",
"54869 -0.178350002 1.4240000 \n",
"60 -0.509249985 -0.4348000 \n",
" BRD-A73513677__CD34__trt_cp BRD-A73558769__CD34__trt_cp ⋯\n",
"5720 0.34680000 0.10225001 ⋯\n",
"466 0.32670000 0.36719999 ⋯\n",
"6009 1.50240004 -0.47415000 ⋯\n",
"2309 -0.58609998 -1.34329998 ⋯\n",
"387 1.18655002 0.68274999 ⋯\n",
"3553 2.93820000 -0.08945002 ⋯\n",
"427 0.57410002 -0.11010003 ⋯\n",
"5898 -0.82900000 -0.52789998 ⋯\n",
"23365 0.49564999 1.38380003 ⋯\n",
"6657 -0.28994998 -0.26674998 ⋯\n",
"5054 -0.07969996 -0.21934998 ⋯\n",
"3108 0.59775001 0.97039998 ⋯\n",
"1950 -0.73095000 -0.51055002 ⋯\n",
"351 0.33724999 -0.51849997 ⋯\n",
"4846 -0.76929998 -0.95864999 ⋯\n",
"1452 0.70099998 0.10130000 ⋯\n",
"4776 0.25165001 0.55704999 ⋯\n",
"6908 0.72994995 0.24660000 ⋯\n",
"672 -0.35640001 -0.57574999 ⋯\n",
"5710 -1.05330002 1.03775001 ⋯\n",
"2115 -0.80159998 -0.07155001 ⋯\n",
"7015 -0.29589999 -0.62774998 ⋯\n",
"8726 -0.07795000 -0.39450002 ⋯\n",
"2185 -0.36440000 0.63944995 ⋯\n",
"3315 -0.12619999 -0.08780000 ⋯\n",
"5289 -0.56045002 -0.05330001 ⋯\n",
"868 -0.48370001 -1.28314996 ⋯\n",
"1677 -0.76335001 -0.10170000 ⋯\n",
"7043 -0.48930001 0.63644999 ⋯\n",
"5613 0.24705002 0.45889997 ⋯\n",
"⋮ ⋮ ⋮ ⋱\n",
"54552 -0.04715000 -0.15339999 ⋯\n",
"54920 -1.17120004 0.30594999 ⋯\n",
"11178 -0.16354999 0.00515002 ⋯\n",
"93643 0.18150002 -1.33759999 ⋯\n",
"112869 -0.80325001 -0.37760001 ⋯\n",
"51147 -0.16949999 0.07554999 ⋯\n",
"196403 -0.13325000 -1.07975006 ⋯\n",
"389677 -0.60355002 -0.66229999 ⋯\n",
"1296 0.10470000 0.11945000 ⋯\n",
"85352 0.69494998 -0.19315001 ⋯\n",
"57610 -0.57225001 0.07119998 ⋯\n",
"27147 -0.54540002 -0.01105000 ⋯\n",
"79591 0.24710000 0.37870002 ⋯\n",
"92595 0.02030000 -0.36090001 ⋯\n",
"51063 0.28309998 0.09540004 ⋯\n",
"55223 -0.73879999 -1.00734997 ⋯\n",
"80022 -0.80614996 0.93999994 ⋯\n",
"55589 0.20385003 -0.57599998 ⋯\n",
"376267 -0.20415001 -0.42180002 ⋯\n",
"84820 -0.12639999 -0.49724999 ⋯\n",
"2931 -0.68005002 0.33640003 ⋯\n",
"63876 -0.44770002 -0.46705002 ⋯\n",
"51275 0.39770001 0.27579999 ⋯\n",
"158747 0.18900004 1.36570001 ⋯\n",
"283232 -0.75310004 0.58985001 ⋯\n",
"25960 0.26474997 0.05900000 ⋯\n",
"6376 -0.22969997 -1.19679999 ⋯\n",
"11033 1.15509999 0.12650001 ⋯\n",
"54869 -0.01594999 1.36944997 ⋯\n",
"60 0.53165001 0.25479999 ⋯\n",
" MW-MITF24__MCF7__trt_cp l-buthionine-sulfoximine__PC3__trt_cp\n",
"5720 -2.1606 -0.2913 \n",
"466 -1.9576 -0.6859 \n",
"6009 -1.9373 -0.7577 \n",
"2309 0.9808 -0.0848 \n",
"387 -1.5168 0.0997 \n",
"3553 3.2767 0.0000 \n",
"427 0.5427 -0.5669 \n",
"5898 -0.3057 0.1609 \n",
"23365 -0.7719 -0.3665 \n",
"6657 2.3400 0.8720 \n",
"5054 0.6593 0.2299 \n",
"3108 0.6745 0.3049 \n",
"1950 0.8943 0.2505 \n",
"351 1.2067 0.8746 \n",
"4846 -1.2723 1.0611 \n",
"1452 -1.9790 0.3489 \n",
"4776 3.3373 0.5311 \n",
"6908 -2.6201 0.3546 \n",
"672 -0.0347 0.5236 \n",
"5710 -0.8548 0.0244 \n",
"2115 1.7185 0.0407 \n",
"7015 1.2487 0.5907 \n",
"8726 -1.6259 -0.1834 \n",
"2185 2.5788 1.2502 \n",
"3315 0.0000 -0.5599 \n",
"5289 0.8281 -0.9206 \n",
"868 0.1421 0.7650 \n",
"1677 0.3969 0.9042 \n",
"7043 0.0147 1.1314 \n",
"5613 0.0717 0.5023 \n",
"⋮ ⋮ ⋮ \n",
"54552 1.8504 -0.2516 \n",
"54920 0.4583 0.8514 \n",
"11178 -1.7519 0.3908 \n",
"93643 2.1395 -0.4617 \n",
"112869 2.3786 1.1703 \n",
"51147 1.9107 1.5612 \n",
"196403 1.4798 0.1850 \n",
"389677 0.6175 -0.6872 \n",
"1296 0.9755 0.6923 \n",
"85352 -0.0009 3.7638 \n",
"57610 1.5447 -0.0599 \n",
"27147 1.3721 -0.4534 \n",
"79591 2.1479 1.1361 \n",
"92595 0.3339 1.3473 \n",
"51063 0.9597 1.8933 \n",
"55223 -0.7425 1.5926 \n",
"80022 1.0909 0.1379 \n",
"55589 -1.7398 1.1566 \n",
"376267 0.1199 1.2685 \n",
"84820 1.1424 -0.0597 \n",
"2931 0.2727 0.5013 \n",
"63876 -0.7579 -0.6265 \n",
"51275 0.3883 0.6793 \n",
"158747 2.4502 1.9125 \n",
"283232 0.3257 1.1194 \n",
"25960 0.8320 -0.3680 \n",
"6376 1.1901 -0.0144 \n",
"11033 1.2484 -0.1491 \n",
"54869 -0.1743 1.0657 \n",
"60 -1.4556 -0.2475 \n",
" alpha-tocopherol__PC3__trt_cp cisplatin__PC3__trt_cp\n",
"5720 -1.2731 -0.5659 \n",
"466 0.5907 -0.2468 \n",
"6009 -1.8149 0.0000 \n",
"2309 -1.5376 0.6194 \n",
"387 -0.3862 0.1973 \n",
"3553 -0.1367 -0.6745 \n",
"427 -0.7753 -0.8029 \n",
"5898 0.2776 0.0750 \n",
"23365 0.7769 0.3405 \n",
"6657 1.4368 0.5604 \n",
"5054 0.5751 0.2370 \n",
"3108 -0.5842 -0.3346 \n",
"1950 1.1675 -0.0811 \n",
"351 -1.4754 0.3245 \n",
"4846 0.0000 0.8742 \n",
"1452 -0.7107 -1.8170 \n",
"4776 1.3320 0.3057 \n",
"6908 -0.8340 0.1707 \n",
"672 -1.3417 0.5860 \n",
"5710 -0.4195 0.8007 \n",
"2115 0.8669 -2.4175 \n",
"7015 0.8714 0.6421 \n",
"8726 -0.9279 -5.2129 \n",
"2185 1.2122 0.2189 \n",
"3315 -0.7747 0.9959 \n",
"5289 0.6822 -0.9480 \n",
"868 0.4446 0.2584 \n",
"1677 0.0418 0.4508 \n",
"7043 1.5184 1.1396 \n",
"5613 0.3477 -2.3664 \n",
"⋮ ⋮ ⋮ \n",
"54552 1.3114 -0.1993 \n",
"54920 0.3027 1.4400 \n",
"11178 -1.0155 -0.2487 \n",
"93643 1.2257 0.0263 \n",
"112869 1.1386 0.7210 \n",
"51147 0.3518 1.2840 \n",
"196403 1.3844 0.3240 \n",
"389677 1.1080 -0.3949 \n",
"1296 -0.1845 0.1797 \n",
"85352 1.6589 0.1591 \n",
"57610 1.6722 0.2858 \n",
"27147 -0.3415 0.3251 \n",
"79591 -0.7604 1.6378 \n",
"92595 0.0010 0.0615 \n",
"51063 1.1444 0.9759 \n",
"55223 0.3204 0.3486 \n",
"80022 0.6538 0.9385 \n",
"55589 -0.5645 1.4264 \n",
"376267 0.9052 0.0267 \n",
"84820 0.7671 0.5935 \n",
"2931 0.8471 0.2688 \n",
"63876 0.8404 -0.2692 \n",
"51275 0.3237 -0.4276 \n",
"158747 0.2526 0.5455 \n",
"283232 0.5754 -0.4345 \n",
"25960 0.6608 -0.2463 \n",
"6376 1.5630 0.3335 \n",
"11033 0.0777 0.3478 \n",
"54869 0.7791 1.0932 \n",
"60 -0.6307 -0.2042 \n",
" iniparib__PC3__trt_cp JMW-MITF1__PC3__trt_cp bortezomib__PC3__trt_cp\n",
"5720 0.4571 0.0308 -0.2913 \n",
"466 0.7582 0.4957 -1.0830 \n",
"6009 0.3941 -1.6190 0.1462 \n",
"2309 -0.2978 0.5139 2.9324 \n",
"387 -0.4246 -0.5682 0.6157 \n",
"3553 -1.0342 -1.3800 -0.9713 \n",
"427 1.6375 1.7251 1.2290 \n",
"5898 -2.8649 0.5809 1.7948 \n",
"23365 -0.6687 0.4276 -2.5250 \n",
"6657 -1.3073 -0.8898 -0.4415 \n",
"5054 0.4596 0.3050 -1.6550 \n",
"3108 1.3939 -0.4618 0.4915 \n",
"1950 -0.4084 -0.6610 -0.0670 \n",
"351 1.2609 0.4734 1.3987 \n",
"4846 0.5819 0.4788 1.4877 \n",
"1452 0.3777 -1.1747 1.5557 \n",
"4776 -0.9554 -0.9277 -1.0772 \n",
"6908 0.7447 0.8058 -0.3623 \n",
"672 0.7067 -0.6479 2.8601 \n",
"5710 0.8163 -0.6469 2.6838 \n",
"2115 -1.3462 0.1283 -0.6444 \n",
"7015 -0.9362 -0.4963 -0.4187 \n",
"8726 -0.4035 0.8041 1.4548 \n",
"2185 -0.3260 -0.4259 -0.4624 \n",
"3315 -0.9554 -0.6129 2.3237 \n",
"5289 -0.2322 -1.1048 0.8300 \n",
"868 0.1067 0.5922 1.3067 \n",
"1677 0.3277 4.0569 -3.5420 \n",
"7043 -0.7535 -0.1550 -0.5552 \n",
"5613 -0.3586 -0.3032 -0.4723 \n",
"⋮ ⋮ ⋮ ⋮ \n",
"54552 -1.4090 -0.4407 -2.0924 \n",
"54920 -1.0779 -0.6745 0.0638 \n",
"11178 -0.6887 -0.6171 -0.5462 \n",
"93643 -1.3893 -1.9883 0.7824 \n",
"112869 -0.1182 -0.0510 -1.0956 \n",
"51147 -1.4728 -0.3504 0.0130 \n",
"196403 -0.4564 0.3414 0.1307 \n",
"389677 -0.7650 0.6032 -0.5789 \n",
"1296 -0.0929 0.0885 0.6156 \n",
"85352 -0.6720 -1.0518 -1.5408 \n",
"57610 1.6272 -0.8244 0.9907 \n",
"27147 -1.3887 0.4315 0.1750 \n",
"79591 -0.0226 0.0510 -0.0003 \n",
"92595 -0.2524 0.0479 -0.3532 \n",
"51063 -0.1300 -0.5763 -0.3481 \n",
"55223 -1.2565 -0.0055 -0.3076 \n",
"80022 -0.8598 -0.1190 -1.1109 \n",
"55589 1.8400 -0.1273 1.2060 \n",
"376267 0.0809 -1.1636 0.2976 \n",
"84820 -0.5742 -1.0844 -0.5707 \n",
"2931 0.7681 -0.5762 -0.8154 \n",
"63876 0.8911 -0.2046 -0.8071 \n",
"51275 0.7665 0.5685 -1.0498 \n",
"158747 0.1402 -0.9180 -1.9362 \n",
"283232 -3.3375 0.5196 -1.5637 \n",
"25960 -2.4105 0.1107 -0.2676 \n",
"6376 1.0411 -1.1291 0.6466 \n",
"11033 -0.7770 -0.2837 -0.0944 \n",
"54869 -0.5247 -0.5104 -0.2863 \n",
"60 0.7773 0.3077 1.8114 \n",
" selumetinib__PC3__trt_cp glutamine__PC3__trt_cp MW-MITF24__PC3__trt_cp\n",
"5720 -0.9489 -1.0550 -1.9929 \n",
"466 0.3153 1.3292 -0.5015 \n",
"6009 -2.1747 -0.2952 -2.1053 \n",
"2309 -0.9933 -0.0140 -1.1789 \n",
"387 -0.3696 0.3436 -3.2787 \n",
"3553 1.2338 -1.3174 -0.6564 \n",
"427 0.0243 -0.7690 -0.6058 \n",
"5898 -0.0093 1.2902 0.2903 \n",
"23365 0.0963 0.0482 0.0963 \n",
"6657 0.7747 -0.3321 2.5004 \n",
"5054 0.0137 0.4267 0.6745 \n",
"3108 0.0590 0.1180 1.7550 \n",
"1950 1.3110 -1.1154 2.5754 \n",
"351 -0.1130 -0.8090 0.3988 \n",
"4846 -0.3579 -0.6335 -0.7591 \n",
"1452 -0.0845 -1.1233 -1.5332 \n",
"4776 0.3361 -0.9042 3.1649 \n",
"6908 -1.9207 0.1919 -1.5016 \n",
"672 2.8988 -0.1277 0.1526 \n",
"5710 -0.4705 -1.5872 -1.9920 \n",
"2115 0.9818 -0.0399 0.1548 \n",
"7015 0.6203 -0.1979 3.4552 \n",
"8726 1.4854 1.7362 1.4854 \n",
"2185 1.4268 -1.4473 2.8440 \n",
"3315 -0.7365 -0.4083 -3.0874 \n",
"5289 0.4654 -0.5206 0.6745 \n",
"868 -0.8527 -0.3135 0.8328 \n",
"1677 -0.8606 -0.0633 2.4948 \n",
"7043 0.9483 0.5121 0.9929 \n",
"5613 -0.3586 -0.7751 1.1149 \n",
"⋮ ⋮ ⋮ ⋮ \n",
"54552 0.6877 0.7649 -0.1186 \n",
"54920 0.4723 0.0850 0.7503 \n",
"11178 -0.1172 -1.4105 0.1631 \n",
"93643 0.2161 -0.5916 2.0450 \n",
"112869 0.8456 -0.5989 1.1402 \n",
"51147 0.4459 -0.4840 0.9162 \n",
"196403 0.2026 -1.4586 1.7090 \n",
"389677 0.8575 1.2912 -0.5854 \n",
"1296 0.2872 -0.6606 0.7912 \n",
"85352 -0.1605 0.1139 2.4243 \n",
"57610 0.4710 0.1368 1.4276 \n",
"27147 -0.6396 -1.0847 1.3937 \n",
"79591 -0.4592 0.8158 1.6554 \n",
"92595 -0.2950 0.0858 0.1184 \n",
"51063 -1.0736 -0.0896 1.2923 \n",
"55223 -0.5895 -0.6759 1.1372 \n",
"80022 0.0832 -0.2971 0.8936 \n",
"55589 0.2184 1.3779 -0.5626 \n",
"376267 1.9446 -0.9014 1.8036 \n",
"84820 2.0601 -0.2694 1.1255 \n",
"2931 -0.0992 -0.7370 1.7226 \n",
"63876 -0.1506 -1.6715 0.9172 \n",
"51275 1.5715 -1.7042 -0.0870 \n",
"158747 1.3076 -0.5795 0.3890 \n",
"283232 1.1416 0.2517 -0.1119 \n",
"25960 0.6119 1.1775 0.9155 \n",
"6376 1.4029 -1.0273 0.0192 \n",
"11033 0.7815 -0.3094 2.2588 \n",
"54869 -0.5035 1.2087 2.5072 \n",
"60 -1.0285 0.0535 -1.3198 "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"query(eh, c(\"signatureSearchData\", \"lincs\"))\n",
"lincs_path <- eh[[\"EH3226\"]]\n",
"h5ls(lincs_path)\n",
"lincs <- SummarizedExperiment(HDF5Array(lincs_path, name=\"assay\"))\n",
"lincs <- as.matrix(lincs@assays@data[[1]])\n",
"rownames(lincs) <- HDF5Array(lincs_path, name=\"rownames\")[,1]\n",
"colnames(lincs) <- HDF5Array(lincs_path, name=\"colnames\")[,1] #12328 x 45956\n",
"lincs"
]
},
{
"cell_type": "code",
"execution_count": 31,
"id": "246033ee-57cb-4f94-87cc-5c4e940eb77d",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:22:12.753494Z",
"iopub.status.busy": "2021-09-23T06:22:12.750009Z",
"iopub.status.idle": "2021-09-23T06:22:12.908881Z",
"shell.execute_reply": "2021-09-23T06:22:12.907709Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"name": "stderr",
"output_type": "stream",
"text": [
"'select()' returned 1:1 mapping between keys and columns\n",
"\n"
]
},
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 4 × 2</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>SYMBOL</th><th scope=col>ENTREZID</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>1</th><td>VENTX</td><td>27287</td></tr>\n",
"\t<tr><th scope=row>2</th><td>OTP </td><td>23440</td></tr>\n",
"\t<tr><th scope=row>3</th><td>ISL1 </td><td>3670 </td></tr>\n",
"\t<tr><th scope=row>4</th><td>HOXC5</td><td>3222 </td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 4 × 2\n",
"\\begin{tabular}{r|ll}\n",
" & SYMBOL & ENTREZID\\\\\n",
" & <chr> & <chr>\\\\\n",
"\\hline\n",
"\t1 & VENTX & 27287\\\\\n",
"\t2 & OTP & 23440\\\\\n",
"\t3 & ISL1 & 3670 \\\\\n",
"\t4 & HOXC5 & 3222 \\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 4 × 2\n",
"\n",
"| <!--/--> | SYMBOL <chr> | ENTREZID <chr> |\n",
"|---|---|---|\n",
"| 1 | VENTX | 27287 |\n",
"| 2 | OTP | 23440 |\n",
"| 3 | ISL1 | 3670 |\n",
"| 4 | HOXC5 | 3222 |\n",
"\n"
],
"text/plain": [
" SYMBOL ENTREZID\n",
"1 VENTX 27287 \n",
"2 OTP 23440 \n",
"3 ISL1 3670 \n",
"4 HOXC5 3222 "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"#### load tumor-specific TFs\n",
"tumor.specific.TFs <- readRDS(\"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/scATAC/5.Motif/Analysis/tumor.specific.TFs.rds\")\n",
"idx <- which(tumor.specific.TFs$Name %in% c(\"HOXC5\", \"VENTX\", \"ISL1\", \"OTP\"))\n",
"tumor.specific.TFs <- tumor.specific.TFs[idx,]\n",
"#convert to entrez id\n",
"source(file = \"/home/longzhilin/Analysis_Code/IDConvert.R\")\n",
"gene.info <- IDConvert(tumor.specific.TFs$Name, method = \"clusterProfiler\", fromType = \"SYMBOL\", toType = \"ENTREZID\")\n",
"gene.info"
]
},
{
"cell_type": "code",
"execution_count": null,
"id": "e9468716-4dad-4a8d-8df4-d1169132a807",
"metadata": {
"vscode": {
"languageId": "r"
}
},
"outputs": [],
"source": []
},
{
"cell_type": "code",
"execution_count": 32,
"id": "62aad8e3-20fb-4ae0-9b99-b33a18cac8f4",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:22:17.113899Z",
"iopub.status.busy": "2021-09-23T06:22:17.109459Z",
"iopub.status.idle": "2021-09-23T06:22:17.249510Z",
"shell.execute_reply": "2021-09-23T06:22:17.248321Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A matrix: 3 × 45956 of type dbl</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>BRD-A03772856__CD34__trt_cp</th><th scope=col>trichostatin-a__CD34__trt_cp</th><th scope=col>geldanamycin__CD34__trt_cp</th><th scope=col>KUC107191N__CD34__trt_cp</th><th scope=col>BRD-A35207501__CD34__trt_cp</th><th scope=col>iloprost__CD34__trt_cp</th><th scope=col>BRD-A72498772__CD34__trt_cp</th><th scope=col>BRD-A72796238__CD34__trt_cp</th><th scope=col>BRD-A73513677__CD34__trt_cp</th><th scope=col>BRD-A73558769__CD34__trt_cp</th><th scope=col>⋯</th><th scope=col>MW-MITF24__MCF7__trt_cp</th><th scope=col>l-buthionine-sulfoximine__PC3__trt_cp</th><th scope=col>alpha-tocopherol__PC3__trt_cp</th><th scope=col>cisplatin__PC3__trt_cp</th><th scope=col>iniparib__PC3__trt_cp</th><th scope=col>JMW-MITF1__PC3__trt_cp</th><th scope=col>bortezomib__PC3__trt_cp</th><th scope=col>selumetinib__PC3__trt_cp</th><th scope=col>glutamine__PC3__trt_cp</th><th scope=col>MW-MITF24__PC3__trt_cp</th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>VENTX</th><td>-0.86745</td><td>2.6854</td><td>2.93140</td><td>0.31655</td><td>0.26720</td><td>1.3062376</td><td>-0.37835</td><td>0.5864</td><td>-0.19235</td><td>-0.36255</td><td>⋯</td><td>1.6858</td><td>0.4772</td><td> 0.6672</td><td>0.4269</td><td>-0.6599</td><td>-0.7321</td><td>-0.5295</td><td>0.8246</td><td>-0.9867</td><td> 1.9501</td></tr>\n",
"\t<tr><th scope=row>ISL1</th><td>-0.18340</td><td>0.0290</td><td>2.10840</td><td>0.86345</td><td>0.12125</td><td>0.4669212</td><td> 0.60240</td><td>1.9325</td><td> 0.64980</td><td>-0.45065</td><td>⋯</td><td>2.4253</td><td>2.1372</td><td>-2.3109</td><td>0.4266</td><td>-0.1666</td><td> 0.6976</td><td>-3.8550</td><td>1.1637</td><td> 0.0608</td><td>-0.5077</td></tr>\n",
"\t<tr><th scope=row>HOXC5</th><td>-0.59025</td><td>3.2782</td><td>2.69445</td><td>1.32265</td><td>0.61415</td><td>2.0156755</td><td>-0.21200</td><td>1.0597</td><td>-0.46980</td><td> 0.28235</td><td>⋯</td><td>1.1215</td><td>0.7762</td><td> 0.2086</td><td>0.1258</td><td>-0.5124</td><td> 0.6798</td><td>-1.9251</td><td>0.6460</td><td>-1.3305</td><td> 0.4147</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A matrix: 3 × 45956 of type dbl\n",
"\\begin{tabular}{r|lllllllllllllllllllll}\n",
" & BRD-A03772856\\_\\_CD34\\_\\_trt\\_cp & trichostatin-a\\_\\_CD34\\_\\_trt\\_cp & geldanamycin\\_\\_CD34\\_\\_trt\\_cp & KUC107191N\\_\\_CD34\\_\\_trt\\_cp & BRD-A35207501\\_\\_CD34\\_\\_trt\\_cp & iloprost\\_\\_CD34\\_\\_trt\\_cp & BRD-A72498772\\_\\_CD34\\_\\_trt\\_cp & BRD-A72796238\\_\\_CD34\\_\\_trt\\_cp & BRD-A73513677\\_\\_CD34\\_\\_trt\\_cp & BRD-A73558769\\_\\_CD34\\_\\_trt\\_cp & ⋯ & MW-MITF24\\_\\_MCF7\\_\\_trt\\_cp & l-buthionine-sulfoximine\\_\\_PC3\\_\\_trt\\_cp & alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & cisplatin\\_\\_PC3\\_\\_trt\\_cp & iniparib\\_\\_PC3\\_\\_trt\\_cp & JMW-MITF1\\_\\_PC3\\_\\_trt\\_cp & bortezomib\\_\\_PC3\\_\\_trt\\_cp & selumetinib\\_\\_PC3\\_\\_trt\\_cp & glutamine\\_\\_PC3\\_\\_trt\\_cp & MW-MITF24\\_\\_PC3\\_\\_trt\\_cp\\\\\n",
"\\hline\n",
"\tVENTX & -0.86745 & 2.6854 & 2.93140 & 0.31655 & 0.26720 & 1.3062376 & -0.37835 & 0.5864 & -0.19235 & -0.36255 & ⋯ & 1.6858 & 0.4772 & 0.6672 & 0.4269 & -0.6599 & -0.7321 & -0.5295 & 0.8246 & -0.9867 & 1.9501\\\\\n",
"\tISL1 & -0.18340 & 0.0290 & 2.10840 & 0.86345 & 0.12125 & 0.4669212 & 0.60240 & 1.9325 & 0.64980 & -0.45065 & ⋯ & 2.4253 & 2.1372 & -2.3109 & 0.4266 & -0.1666 & 0.6976 & -3.8550 & 1.1637 & 0.0608 & -0.5077\\\\\n",
"\tHOXC5 & -0.59025 & 3.2782 & 2.69445 & 1.32265 & 0.61415 & 2.0156755 & -0.21200 & 1.0597 & -0.46980 & 0.28235 & ⋯ & 1.1215 & 0.7762 & 0.2086 & 0.1258 & -0.5124 & 0.6798 & -1.9251 & 0.6460 & -1.3305 & 0.4147\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A matrix: 3 × 45956 of type dbl\n",
"\n",
"| <!--/--> | BRD-A03772856__CD34__trt_cp | trichostatin-a__CD34__trt_cp | geldanamycin__CD34__trt_cp | KUC107191N__CD34__trt_cp | BRD-A35207501__CD34__trt_cp | iloprost__CD34__trt_cp | BRD-A72498772__CD34__trt_cp | BRD-A72796238__CD34__trt_cp | BRD-A73513677__CD34__trt_cp | BRD-A73558769__CD34__trt_cp | ⋯ | MW-MITF24__MCF7__trt_cp | l-buthionine-sulfoximine__PC3__trt_cp | alpha-tocopherol__PC3__trt_cp | cisplatin__PC3__trt_cp | iniparib__PC3__trt_cp | JMW-MITF1__PC3__trt_cp | bortezomib__PC3__trt_cp | selumetinib__PC3__trt_cp | glutamine__PC3__trt_cp | MW-MITF24__PC3__trt_cp |\n",
"|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
"| VENTX | -0.86745 | 2.6854 | 2.93140 | 0.31655 | 0.26720 | 1.3062376 | -0.37835 | 0.5864 | -0.19235 | -0.36255 | ⋯ | 1.6858 | 0.4772 | 0.6672 | 0.4269 | -0.6599 | -0.7321 | -0.5295 | 0.8246 | -0.9867 | 1.9501 |\n",
"| ISL1 | -0.18340 | 0.0290 | 2.10840 | 0.86345 | 0.12125 | 0.4669212 | 0.60240 | 1.9325 | 0.64980 | -0.45065 | ⋯ | 2.4253 | 2.1372 | -2.3109 | 0.4266 | -0.1666 | 0.6976 | -3.8550 | 1.1637 | 0.0608 | -0.5077 |\n",
"| HOXC5 | -0.59025 | 3.2782 | 2.69445 | 1.32265 | 0.61415 | 2.0156755 | -0.21200 | 1.0597 | -0.46980 | 0.28235 | ⋯ | 1.1215 | 0.7762 | 0.2086 | 0.1258 | -0.5124 | 0.6798 | -1.9251 | 0.6460 | -1.3305 | 0.4147 |\n",
"\n"
],
"text/plain": [
" BRD-A03772856__CD34__trt_cp trichostatin-a__CD34__trt_cp\n",
"VENTX -0.86745 2.6854 \n",
"ISL1 -0.18340 0.0290 \n",
"HOXC5 -0.59025 3.2782 \n",
" geldanamycin__CD34__trt_cp KUC107191N__CD34__trt_cp\n",
"VENTX 2.93140 0.31655 \n",
"ISL1 2.10840 0.86345 \n",
"HOXC5 2.69445 1.32265 \n",
" BRD-A35207501__CD34__trt_cp iloprost__CD34__trt_cp\n",
"VENTX 0.26720 1.3062376 \n",
"ISL1 0.12125 0.4669212 \n",
"HOXC5 0.61415 2.0156755 \n",
" BRD-A72498772__CD34__trt_cp BRD-A72796238__CD34__trt_cp\n",
"VENTX -0.37835 0.5864 \n",
"ISL1 0.60240 1.9325 \n",
"HOXC5 -0.21200 1.0597 \n",
" BRD-A73513677__CD34__trt_cp BRD-A73558769__CD34__trt_cp ⋯\n",
"VENTX -0.19235 -0.36255 ⋯\n",
"ISL1 0.64980 -0.45065 ⋯\n",
"HOXC5 -0.46980 0.28235 ⋯\n",
" MW-MITF24__MCF7__trt_cp l-buthionine-sulfoximine__PC3__trt_cp\n",
"VENTX 1.6858 0.4772 \n",
"ISL1 2.4253 2.1372 \n",
"HOXC5 1.1215 0.7762 \n",
" alpha-tocopherol__PC3__trt_cp cisplatin__PC3__trt_cp\n",
"VENTX 0.6672 0.4269 \n",
"ISL1 -2.3109 0.4266 \n",
"HOXC5 0.2086 0.1258 \n",
" iniparib__PC3__trt_cp JMW-MITF1__PC3__trt_cp bortezomib__PC3__trt_cp\n",
"VENTX -0.6599 -0.7321 -0.5295 \n",
"ISL1 -0.1666 0.6976 -3.8550 \n",
"HOXC5 -0.5124 0.6798 -1.9251 \n",
" selumetinib__PC3__trt_cp glutamine__PC3__trt_cp MW-MITF24__PC3__trt_cp\n",
"VENTX 0.8246 -0.9867 1.9501 \n",
"ISL1 1.1637 0.0608 -0.5077 \n",
"HOXC5 0.6460 -1.3305 0.4147 "
]
},
"metadata": {},
"output_type": "display_data"
},
{
"data": {
"text/html": [
"<style>\n",
".list-inline {list-style: none; margin:0; padding: 0}\n",
".list-inline>li {display: inline-block}\n",
".list-inline>li:not(:last-child)::after {content: \"\\00b7\"; padding: 0 .5ex}\n",
"</style>\n",
"<ol class=list-inline><li>3</li><li>45956</li></ol>\n"
],
"text/latex": [
"\\begin{enumerate*}\n",
"\\item 3\n",
"\\item 45956\n",
"\\end{enumerate*}\n"
],
"text/markdown": [
"1. 3\n",
"2. 45956\n",
"\n",
"\n"
],
"text/plain": [
"[1] 3 45956"
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"index <- match(gene.info$ENTREZID, rownames(lincs))\n",
"lincs.TF.matrix <- lincs[na.omit(index),]\n",
"rownames(lincs.TF.matrix) <- gene.info$SYMBOL[which(!is.na(index))]\n",
"lincs.TF.matrix\n",
"dim(lincs.TF.matrix)"
]
},
{
"cell_type": "code",
"execution_count": 33,
"id": "d4a31f92-a011-4a97-be3b-347fc8c2f761",
"metadata": {
"collapsed": true,
"execution": {
"iopub.execute_input": "2021-09-23T06:22:27.432913Z",
"iopub.status.busy": "2021-09-23T06:22:27.429496Z",
"iopub.status.idle": "2021-09-23T06:22:27.599993Z",
"shell.execute_reply": "2021-09-23T06:22:27.598811Z"
},
"jupyter": {
"outputs_hidden": true
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<dl>\n",
"\t<dt>$VENTX</dt>\n",
"\t\t<dd><table class=\"dataframe\">\n",
"<caption>A data.frame: 80 × 2</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>drug</th><th scope=col>zscore</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><dbl></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>butoconazole__HCC515__trt_cp</th><td>butoconazole__HCC515__trt_cp</td><td>-2.043097</td></tr>\n",
"\t<tr><th scope=row>amcinonide__VCAP__trt_cp</th><td>amcinonide__VCAP__trt_cp </td><td>-2.013700</td></tr>\n",
"\t<tr><th scope=row>verteporfin__VCAP__trt_cp</th><td>verteporfin__VCAP__trt_cp </td><td>-2.372383</td></tr>\n",
"\t<tr><th scope=row>napelline__HT29__trt_cp</th><td>napelline__HT29__trt_cp </td><td>-2.024536</td></tr>\n",
"\t<tr><th scope=row>clioquinol__HT29__trt_cp</th><td>clioquinol__HT29__trt_cp </td><td>-2.086267</td></tr>\n",
"\t<tr><th scope=row>NS-3694__VCAP__trt_cp</th><td>NS-3694__VCAP__trt_cp </td><td>-2.178900</td></tr>\n",
"\t<tr><th scope=row>AS-605240__VCAP__trt_cp</th><td>AS-605240__VCAP__trt_cp </td><td>-2.451528</td></tr>\n",
"\t<tr><th scope=row>SJ-172550__VCAP__trt_cp</th><td>SJ-172550__VCAP__trt_cp </td><td>-2.893954</td></tr>\n",
"\t<tr><th scope=row>JAS07-005__VCAP__trt_cp</th><td>JAS07-005__VCAP__trt_cp </td><td>-2.086582</td></tr>\n",
"\t<tr><th scope=row>BRD-A38425832__MCF7__trt_cp</th><td>BRD-A38425832__MCF7__trt_cp </td><td>-2.438600</td></tr>\n",
"\t<tr><th scope=row>BRD-K32827536__PC3__trt_cp</th><td>BRD-K32827536__PC3__trt_cp </td><td>-2.027371</td></tr>\n",
"\t<tr><th scope=row>BRD-K48844671__PC3__trt_cp</th><td>BRD-K48844671__PC3__trt_cp </td><td>-2.115793</td></tr>\n",
"\t<tr><th scope=row>BRD-K23165181__VCAP__trt_cp</th><td>BRD-K23165181__VCAP__trt_cp </td><td>-2.151439</td></tr>\n",
"\t<tr><th scope=row>BRD-K58247702__VCAP__trt_cp</th><td>BRD-K58247702__VCAP__trt_cp </td><td>-2.014121</td></tr>\n",
"\t<tr><th scope=row>BRD-K70917163__VCAP__trt_cp</th><td>BRD-K70917163__VCAP__trt_cp </td><td>-2.195663</td></tr>\n",
"\t<tr><th scope=row>KU-C104140__A549__trt_cp</th><td>KU-C104140__A549__trt_cp </td><td>-2.076100</td></tr>\n",
"\t<tr><th scope=row>BRD-A11095214__MCF7__trt_cp</th><td>BRD-A11095214__MCF7__trt_cp </td><td>-2.200500</td></tr>\n",
"\t<tr><th scope=row>BRD-K33182644__MCF7__trt_cp</th><td>BRD-K33182644__MCF7__trt_cp </td><td>-2.137250</td></tr>\n",
"\t<tr><th scope=row>BRD-K98991361__A549__trt_cp</th><td>BRD-K98991361__A549__trt_cp </td><td>-2.161300</td></tr>\n",
"\t<tr><th scope=row>oxcarbazepine__MCF7__trt_cp</th><td>oxcarbazepine__MCF7__trt_cp </td><td>-2.080350</td></tr>\n",
"\t<tr><th scope=row>lansoprazole__VCAP__trt_cp</th><td>lansoprazole__VCAP__trt_cp </td><td>-2.672177</td></tr>\n",
"\t<tr><th scope=row>kitasamycin__VCAP__trt_cp</th><td>kitasamycin__VCAP__trt_cp </td><td>-2.771939</td></tr>\n",
"\t<tr><th scope=row>BRD-A16581344__A549__trt_cp</th><td>BRD-A16581344__A549__trt_cp </td><td>-2.207200</td></tr>\n",
"\t<tr><th scope=row>BRD-K88556033__A549__trt_cp</th><td>BRD-K88556033__A549__trt_cp </td><td>-2.038800</td></tr>\n",
"\t<tr><th scope=row>RAN-27__NEU__trt_cp</th><td>RAN-27__NEU__trt_cp </td><td>-2.076294</td></tr>\n",
"\t<tr><th scope=row>BRD-K44893543__NEU__trt_cp</th><td>BRD-K44893543__NEU__trt_cp </td><td>-2.608974</td></tr>\n",
"\t<tr><th scope=row>BRD-K58279162__NEU__trt_cp</th><td>BRD-K58279162__NEU__trt_cp </td><td>-2.688838</td></tr>\n",
"\t<tr><th scope=row>BRD-K14316227__NPC__trt_cp</th><td>BRD-K14316227__NPC__trt_cp </td><td>-2.204158</td></tr>\n",
"\t<tr><th scope=row>treprostinil__PHH__trt_cp</th><td>treprostinil__PHH__trt_cp </td><td>-2.756694</td></tr>\n",
"\t<tr><th scope=row>BRD-K82971429__PHH__trt_cp</th><td>BRD-K82971429__PHH__trt_cp </td><td>-2.028831</td></tr>\n",
"\t<tr><th scope=row>⋮</th><td>⋮</td><td>⋮</td></tr>\n",
"\t<tr><th scope=row>NSC-663284__PHH__trt_cp</th><td>NSC-663284__PHH__trt_cp </td><td>-2.211250</td></tr>\n",
"\t<tr><th scope=row>zoxazolamine__PHH__trt_cp</th><td>zoxazolamine__PHH__trt_cp </td><td>-2.148100</td></tr>\n",
"\t<tr><th scope=row>nateglinide__PHH__trt_cp</th><td>nateglinide__PHH__trt_cp </td><td>-2.026000</td></tr>\n",
"\t<tr><th scope=row>LFM-A13__NEU__trt_cp</th><td>LFM-A13__NEU__trt_cp </td><td>-2.864500</td></tr>\n",
"\t<tr><th scope=row>BML-257__NEU__trt_cp</th><td>BML-257__NEU__trt_cp </td><td>-3.350300</td></tr>\n",
"\t<tr><th scope=row>lamotrigine__NEU__trt_cp</th><td>lamotrigine__NEU__trt_cp </td><td>-2.059334</td></tr>\n",
"\t<tr><th scope=row>IC-261__PHH__trt_cp</th><td>IC-261__PHH__trt_cp </td><td>-2.089171</td></tr>\n",
"\t<tr><th scope=row>L-701252__PHH__trt_cp</th><td>L-701252__PHH__trt_cp </td><td>-3.265500</td></tr>\n",
"\t<tr><th scope=row>mometasone__PHH__trt_cp</th><td>mometasone__PHH__trt_cp </td><td>-2.173689</td></tr>\n",
"\t<tr><th scope=row>scoulerine__PHH__trt_cp</th><td>scoulerine__PHH__trt_cp </td><td>-2.078122</td></tr>\n",
"\t<tr><th scope=row>dihydroergotamine__PHH__trt_cp</th><td>dihydroergotamine__PHH__trt_cp </td><td>-2.580976</td></tr>\n",
"\t<tr><th scope=row>dipyridamole__PHH__trt_cp</th><td>dipyridamole__PHH__trt_cp </td><td>-2.045686</td></tr>\n",
"\t<tr><th scope=row>tyrphostin-AG-825__MCF7__trt_cp</th><td>tyrphostin-AG-825__MCF7__trt_cp</td><td>-2.394913</td></tr>\n",
"\t<tr><th scope=row>rosmarinic-acid__NPC__trt_cp</th><td>rosmarinic-acid__NPC__trt_cp </td><td>-2.170692</td></tr>\n",
"\t<tr><th scope=row>amthamine__PHH__trt_cp</th><td>amthamine__PHH__trt_cp </td><td>-2.258550</td></tr>\n",
"\t<tr><th scope=row>NAN-190__PHH__trt_cp</th><td>NAN-190__PHH__trt_cp </td><td>-4.584300</td></tr>\n",
"\t<tr><th scope=row>BRD-K24053449__MCF7__trt_cp</th><td>BRD-K24053449__MCF7__trt_cp </td><td>-2.124968</td></tr>\n",
"\t<tr><th scope=row>BRD-K88278225__PC3__trt_cp</th><td>BRD-K88278225__PC3__trt_cp </td><td>-5.143122</td></tr>\n",
"\t<tr><th scope=row>BRD-K03358980__VCAP__trt_cp</th><td>BRD-K03358980__VCAP__trt_cp </td><td>-2.230576</td></tr>\n",
"\t<tr><th scope=row>BRD-K06592610__VCAP__trt_cp</th><td>BRD-K06592610__VCAP__trt_cp </td><td>-2.063635</td></tr>\n",
"\t<tr><th scope=row>RDR-01440SC__VCAP__trt_cp</th><td>RDR-01440SC__VCAP__trt_cp </td><td>-2.042054</td></tr>\n",
"\t<tr><th scope=row>BRD-K76691125__VCAP__trt_cp</th><td>BRD-K76691125__VCAP__trt_cp </td><td>-2.113669</td></tr>\n",
"\t<tr><th scope=row>tubacin__VCAP__trt_cp</th><td>tubacin__VCAP__trt_cp </td><td>-3.499640</td></tr>\n",
"\t<tr><th scope=row>BRD-K47512679__NPC__trt_cp</th><td>BRD-K47512679__NPC__trt_cp </td><td>-2.032956</td></tr>\n",
"\t<tr><th scope=row>BRD-K05353139__HT29__trt_cp</th><td>BRD-K05353139__HT29__trt_cp </td><td>-2.013206</td></tr>\n",
"\t<tr><th scope=row>BRD-K48598367__NEU__trt_cp</th><td>BRD-K48598367__NEU__trt_cp </td><td>-2.556500</td></tr>\n",
"\t<tr><th scope=row>SA-419083__NPC__trt_cp</th><td>SA-419083__NPC__trt_cp </td><td>-2.028479</td></tr>\n",
"\t<tr><th scope=row>BRD-K28772322__VCAP__trt_cp</th><td>BRD-K28772322__VCAP__trt_cp </td><td>-2.263741</td></tr>\n",
"\t<tr><th scope=row>nocodazole__FIBRNPC__trt_cp</th><td>nocodazole__FIBRNPC__trt_cp </td><td>-2.172350</td></tr>\n",
"\t<tr><th scope=row>AVA__HA1E__trt_cp</th><td>AVA__HA1E__trt_cp </td><td>-2.028199</td></tr>\n",
"</tbody>\n",
"</table>\n",
"</dd>\n",
"\t<dt>$ISL1</dt>\n",
"\t\t<dd><table class=\"dataframe\">\n",
"<caption>A data.frame: 197 × 2</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>drug</th><th scope=col>zscore</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><dbl></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>BRD-K26684619__CD34__trt_cp</th><td>BRD-K26684619__CD34__trt_cp </td><td>-2.040950</td></tr>\n",
"\t<tr><th scope=row>BRD-A51929314__HA1E__trt_cp</th><td>BRD-A51929314__HA1E__trt_cp </td><td>-2.227154</td></tr>\n",
"\t<tr><th scope=row>MRS-1845__HCC515__trt_cp</th><td>MRS-1845__HCC515__trt_cp </td><td>-2.417191</td></tr>\n",
"\t<tr><th scope=row>melperone__HCC515__trt_cp</th><td>melperone__HCC515__trt_cp </td><td>-2.385237</td></tr>\n",
"\t<tr><th scope=row>FCCP__HCC515__trt_cp</th><td>FCCP__HCC515__trt_cp </td><td>-2.176191</td></tr>\n",
"\t<tr><th scope=row>BCL2-inhibitor__VCAP__trt_cp</th><td>BCL2-inhibitor__VCAP__trt_cp </td><td>-2.520154</td></tr>\n",
"\t<tr><th scope=row>ubenimex__VCAP__trt_cp</th><td>ubenimex__VCAP__trt_cp </td><td>-2.167702</td></tr>\n",
"\t<tr><th scope=row>epitestosterone__VCAP__trt_cp</th><td>epitestosterone__VCAP__trt_cp </td><td>-2.142600</td></tr>\n",
"\t<tr><th scope=row>procainamide__VCAP__trt_cp</th><td>procainamide__VCAP__trt_cp </td><td>-2.136900</td></tr>\n",
"\t<tr><th scope=row>anagrelide__HA1E__trt_cp</th><td>anagrelide__HA1E__trt_cp </td><td>-2.888882</td></tr>\n",
"\t<tr><th scope=row>bithionol__HCC515__trt_cp</th><td>bithionol__HCC515__trt_cp </td><td>-2.335168</td></tr>\n",
"\t<tr><th scope=row>GW-1929__VCAP__trt_cp</th><td>GW-1929__VCAP__trt_cp </td><td>-3.890623</td></tr>\n",
"\t<tr><th scope=row>CMPD-1__A375__trt_cp</th><td>CMPD-1__A375__trt_cp </td><td>-2.118605</td></tr>\n",
"\t<tr><th scope=row>ST-638__HA1E__trt_cp</th><td>ST-638__HA1E__trt_cp </td><td>-2.139165</td></tr>\n",
"\t<tr><th scope=row>fluocinolone-acetonide__HT29__trt_cp</th><td>fluocinolone-acetonide__HT29__trt_cp</td><td>-2.311850</td></tr>\n",
"\t<tr><th scope=row>mitoxantrone__HT29__trt_cp</th><td>mitoxantrone__HT29__trt_cp </td><td>-2.173384</td></tr>\n",
"\t<tr><th scope=row>L-168049__VCAP__trt_cp</th><td>L-168049__VCAP__trt_cp </td><td>-2.498789</td></tr>\n",
"\t<tr><th scope=row>BX-795__HT29__trt_cp</th><td>BX-795__HT29__trt_cp </td><td>-2.146887</td></tr>\n",
"\t<tr><th scope=row>cucurbitacin-i__MCF7__trt_cp</th><td>cucurbitacin-i__MCF7__trt_cp </td><td>-2.131572</td></tr>\n",
"\t<tr><th scope=row>CT-200783__VCAP__trt_cp</th><td>CT-200783__VCAP__trt_cp </td><td>-2.346538</td></tr>\n",
"\t<tr><th scope=row>BRD-K60870698__A375__trt_cp</th><td>BRD-K60870698__A375__trt_cp </td><td>-2.611861</td></tr>\n",
"\t<tr><th scope=row>BRD-K84203638__A375__trt_cp</th><td>BRD-K84203638__A375__trt_cp </td><td>-2.241982</td></tr>\n",
"\t<tr><th scope=row>BRD-K05153001__A549__trt_cp</th><td>BRD-K05153001__A549__trt_cp </td><td>-2.140815</td></tr>\n",
"\t<tr><th scope=row>BRD-K85275009__A549__trt_cp</th><td>BRD-K85275009__A549__trt_cp </td><td>-4.711900</td></tr>\n",
"\t<tr><th scope=row>BRD-K05402890__HA1E__trt_cp</th><td>BRD-K05402890__HA1E__trt_cp </td><td>-2.309873</td></tr>\n",
"\t<tr><th scope=row>BRD-A58924247__HT29__trt_cp</th><td>BRD-A58924247__HT29__trt_cp </td><td>-2.229404</td></tr>\n",
"\t<tr><th scope=row>BRD-K91691979__PC3__trt_cp</th><td>BRD-K91691979__PC3__trt_cp </td><td>-2.309459</td></tr>\n",
"\t<tr><th scope=row>BRD-K19735876__A375__trt_cp</th><td>BRD-K19735876__A375__trt_cp </td><td>-2.083350</td></tr>\n",
"\t<tr><th scope=row>BRD-A21406558__MCF7__trt_cp</th><td>BRD-A21406558__MCF7__trt_cp </td><td>-2.156250</td></tr>\n",
"\t<tr><th scope=row>BRD-K07259155__MCF7__trt_cp</th><td>BRD-K07259155__MCF7__trt_cp </td><td>-2.299050</td></tr>\n",
"\t<tr><th scope=row>⋮</th><td>⋮</td><td>⋮</td></tr>\n",
"\t<tr><th scope=row>SR-12813__NEU__trt_cp</th><td>SR-12813__NEU__trt_cp </td><td>-2.061450</td></tr>\n",
"\t<tr><th scope=row>LBH-589__NEU__trt_cp</th><td>LBH-589__NEU__trt_cp </td><td>-2.051542</td></tr>\n",
"\t<tr><th scope=row>BG-1003__NPC__trt_cp</th><td>BG-1003__NPC__trt_cp </td><td>-2.050464</td></tr>\n",
"\t<tr><th scope=row>LBH-589__NPC__trt_cp</th><td>LBH-589__NPC__trt_cp </td><td>-2.351810</td></tr>\n",
"\t<tr><th scope=row>BG-1008__NEU__trt_cp</th><td>BG-1008__NEU__trt_cp </td><td>-2.506527</td></tr>\n",
"\t<tr><th scope=row>temozolomide__NEU__trt_cp</th><td>temozolomide__NEU__trt_cp </td><td>-2.358148</td></tr>\n",
"\t<tr><th scope=row>BG-1005__NEU__trt_cp</th><td>BG-1005__NEU__trt_cp </td><td>-2.408175</td></tr>\n",
"\t<tr><th scope=row>BG-1025__NEU__trt_cp</th><td>BG-1025__NEU__trt_cp </td><td>-2.330200</td></tr>\n",
"\t<tr><th scope=row>C2-dihydroceramide__NEU__trt_cp</th><td>C2-dihydroceramide__NEU__trt_cp </td><td>-2.060200</td></tr>\n",
"\t<tr><th scope=row>BG-1030__NEU__trt_cp</th><td>BG-1030__NEU__trt_cp </td><td>-2.047566</td></tr>\n",
"\t<tr><th scope=row>oxamflatin__NPC__trt_cp</th><td>oxamflatin__NPC__trt_cp </td><td>-2.670142</td></tr>\n",
"\t<tr><th scope=row>BG-1029__NPC__trt_cp</th><td>BG-1029__NPC__trt_cp </td><td>-2.168213</td></tr>\n",
"\t<tr><th scope=row>BG-1006__NPC__trt_cp</th><td>BG-1006__NPC__trt_cp </td><td>-2.664152</td></tr>\n",
"\t<tr><th scope=row>BML-284__NPC__trt_cp</th><td>BML-284__NPC__trt_cp </td><td>-4.036828</td></tr>\n",
"\t<tr><th scope=row>M-344__NPC__trt_cp</th><td>M-344__NPC__trt_cp </td><td>-2.041860</td></tr>\n",
"\t<tr><th scope=row>BG-1025__NPC__trt_cp</th><td>BG-1025__NPC__trt_cp </td><td>-2.107575</td></tr>\n",
"\t<tr><th scope=row>BG-1026__NPC__trt_cp</th><td>BG-1026__NPC__trt_cp </td><td>-2.440128</td></tr>\n",
"\t<tr><th scope=row>NCH-51__NPC__trt_cp</th><td>NCH-51__NPC__trt_cp </td><td>-2.122013</td></tr>\n",
"\t<tr><th scope=row>BG-1007__NPC__trt_cp</th><td>BG-1007__NPC__trt_cp </td><td>-2.229874</td></tr>\n",
"\t<tr><th scope=row>BG-1028__NPC__trt_cp</th><td>BG-1028__NPC__trt_cp </td><td>-2.391268</td></tr>\n",
"\t<tr><th scope=row>BG-1027__NPC__trt_cp</th><td>BG-1027__NPC__trt_cp </td><td>-2.334610</td></tr>\n",
"\t<tr><th scope=row>tert-butylhydroquinone__MCF7__trt_cp</th><td>tert-butylhydroquinone__MCF7__trt_cp</td><td>-3.080953</td></tr>\n",
"\t<tr><th scope=row>panobinostat__A375__trt_cp</th><td>panobinostat__A375__trt_cp </td><td>-2.063759</td></tr>\n",
"\t<tr><th scope=row>staurosporine__A375__trt_cp</th><td>staurosporine__A375__trt_cp </td><td>-3.507200</td></tr>\n",
"\t<tr><th scope=row>apicidin__A375__trt_cp</th><td>apicidin__A375__trt_cp </td><td>-2.681550</td></tr>\n",
"\t<tr><th scope=row>BRD-K57064803__MCF7__trt_cp</th><td>BRD-K57064803__MCF7__trt_cp </td><td>-2.356925</td></tr>\n",
"\t<tr><th scope=row>alpha-tocopherol__MCF7__trt_cp</th><td>alpha-tocopherol__MCF7__trt_cp </td><td>-2.502400</td></tr>\n",
"\t<tr><th scope=row>JMW-MITF1__MCF7__trt_cp</th><td>JMW-MITF1__MCF7__trt_cp </td><td>-2.199600</td></tr>\n",
"\t<tr><th scope=row>alpha-tocopherol__PC3__trt_cp</th><td>alpha-tocopherol__PC3__trt_cp </td><td>-2.310900</td></tr>\n",
"\t<tr><th scope=row>bortezomib__PC3__trt_cp</th><td>bortezomib__PC3__trt_cp </td><td>-3.855000</td></tr>\n",
"</tbody>\n",
"</table>\n",
"</dd>\n",
"\t<dt>$HOXC5</dt>\n",
"\t\t<dd><table class=\"dataframe\">\n",
"<caption>A data.frame: 49 × 2</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>drug</th><th scope=col>zscore</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><dbl></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>aminomethyltransferase__HA1E__trt_cp</th><td>aminomethyltransferase__HA1E__trt_cp </td><td>-2.349426</td></tr>\n",
"\t<tr><th scope=row>ARP-101__HA1E__trt_cp</th><td>ARP-101__HA1E__trt_cp </td><td>-2.420850</td></tr>\n",
"\t<tr><th scope=row>homoharringtonine__HA1E__trt_cp</th><td>homoharringtonine__HA1E__trt_cp </td><td>-2.545411</td></tr>\n",
"\t<tr><th scope=row>CFM-1571__HCC515__trt_cp</th><td>CFM-1571__HCC515__trt_cp </td><td>-2.027797</td></tr>\n",
"\t<tr><th scope=row>apoptosis-activator-II__HCC515__trt_cp</th><td>apoptosis-activator-II__HCC515__trt_cp</td><td>-2.027338</td></tr>\n",
"\t<tr><th scope=row>puromycin__VCAP__trt_cp</th><td>puromycin__VCAP__trt_cp </td><td>-3.208967</td></tr>\n",
"\t<tr><th scope=row>NSC-632839__VCAP__trt_cp</th><td>NSC-632839__VCAP__trt_cp </td><td>-2.437900</td></tr>\n",
"\t<tr><th scope=row>NNC-711__VCAP__trt_cp</th><td>NNC-711__VCAP__trt_cp </td><td>-2.587158</td></tr>\n",
"\t<tr><th scope=row>MG-132__VCAP__trt_cp</th><td>MG-132__VCAP__trt_cp </td><td>-2.497801</td></tr>\n",
"\t<tr><th scope=row>Ro-15-4513__VCAP__trt_cp</th><td>Ro-15-4513__VCAP__trt_cp </td><td>-2.462467</td></tr>\n",
"\t<tr><th scope=row>R-59022__HA1E__trt_cp</th><td>R-59022__HA1E__trt_cp </td><td>-2.440392</td></tr>\n",
"\t<tr><th scope=row>cucurbitacin-i__MCF7__trt_cp</th><td>cucurbitacin-i__MCF7__trt_cp </td><td>-2.504937</td></tr>\n",
"\t<tr><th scope=row>SCH-79797__MCF7__trt_cp</th><td>SCH-79797__MCF7__trt_cp </td><td>-3.103155</td></tr>\n",
"\t<tr><th scope=row>BRD-K19290969__A549__trt_cp</th><td>BRD-K19290969__A549__trt_cp </td><td>-2.442208</td></tr>\n",
"\t<tr><th scope=row>BIX-02188__VCAP__trt_cp</th><td>BIX-02188__VCAP__trt_cp </td><td>-2.021193</td></tr>\n",
"\t<tr><th scope=row>BRD-A98444709__A549__trt_cp</th><td>BRD-A98444709__A549__trt_cp </td><td>-2.181950</td></tr>\n",
"\t<tr><th scope=row>BRD-K18726304__MCF7__trt_cp</th><td>BRD-K18726304__MCF7__trt_cp </td><td>-2.498750</td></tr>\n",
"\t<tr><th scope=row>toremifene__MCF7__trt_cp</th><td>toremifene__MCF7__trt_cp </td><td>-2.111762</td></tr>\n",
"\t<tr><th scope=row>BRD-K32896438__MCF7__trt_cp</th><td>BRD-K32896438__MCF7__trt_cp </td><td>-2.568452</td></tr>\n",
"\t<tr><th scope=row>RAN-27__NEU__trt_cp</th><td>RAN-27__NEU__trt_cp </td><td>-2.057970</td></tr>\n",
"\t<tr><th scope=row>BRD-K44893543__NEU__trt_cp</th><td>BRD-K44893543__NEU__trt_cp </td><td>-2.403568</td></tr>\n",
"\t<tr><th scope=row>cytochalasin-d__MCF7__trt_cp</th><td>cytochalasin-d__MCF7__trt_cp </td><td>-2.524929</td></tr>\n",
"\t<tr><th scope=row>ST-4029010__NEU__trt_cp</th><td>ST-4029010__NEU__trt_cp </td><td>-2.160550</td></tr>\n",
"\t<tr><th scope=row>sorafenib__VCAP__trt_cp</th><td>sorafenib__VCAP__trt_cp </td><td>-2.387828</td></tr>\n",
"\t<tr><th scope=row>BG-FA-0953__VCAP__trt_cp</th><td>BG-FA-0953__VCAP__trt_cp </td><td>-2.010978</td></tr>\n",
"\t<tr><th scope=row>WYE-354__ASC__trt_cp</th><td>WYE-354__ASC__trt_cp </td><td>-2.030976</td></tr>\n",
"\t<tr><th scope=row>WYE-125132__MCF7__trt_cp</th><td>WYE-125132__MCF7__trt_cp </td><td>-2.019033</td></tr>\n",
"\t<tr><th scope=row>verrucarin-a__NEU__trt_cp</th><td>verrucarin-a__NEU__trt_cp </td><td>-2.535550</td></tr>\n",
"\t<tr><th scope=row>mirin__VCAP__trt_cp</th><td>mirin__VCAP__trt_cp </td><td>-2.051119</td></tr>\n",
"\t<tr><th scope=row>CGP-71683__MCF7__trt_cp</th><td>CGP-71683__MCF7__trt_cp </td><td>-2.191356</td></tr>\n",
"\t<tr><th scope=row>NSC-663284__PHH__trt_cp</th><td>NSC-663284__PHH__trt_cp </td><td>-2.232050</td></tr>\n",
"\t<tr><th scope=row>proadifen__ASC__trt_cp</th><td>proadifen__ASC__trt_cp </td><td>-2.171099</td></tr>\n",
"\t<tr><th scope=row>anisomycin__NEU__trt_cp</th><td>anisomycin__NEU__trt_cp </td><td>-2.530992</td></tr>\n",
"\t<tr><th scope=row>formoterol__SKB__trt_cp</th><td>formoterol__SKB__trt_cp </td><td>-2.052984</td></tr>\n",
"\t<tr><th scope=row>FCCP__MCF7__trt_cp</th><td>FCCP__MCF7__trt_cp </td><td>-2.068842</td></tr>\n",
"\t<tr><th scope=row>diphenyleneiodonium__MCF7__trt_cp</th><td>diphenyleneiodonium__MCF7__trt_cp </td><td>-2.738179</td></tr>\n",
"\t<tr><th scope=row>NSC-94258__MCF7__trt_cp</th><td>NSC-94258__MCF7__trt_cp </td><td>-2.348442</td></tr>\n",
"\t<tr><th scope=row>SQ-22536__NPC__trt_cp</th><td>SQ-22536__NPC__trt_cp </td><td>-2.024650</td></tr>\n",
"\t<tr><th scope=row>pyrvinium__MCF7__trt_cp</th><td>pyrvinium__MCF7__trt_cp </td><td>-2.287450</td></tr>\n",
"\t<tr><th scope=row>BRD-K00835201__NEU__trt_cp</th><td>BRD-K00835201__NEU__trt_cp </td><td>-2.013800</td></tr>\n",
"\t<tr><th scope=row>BRD-K75264577__NEU__trt_cp</th><td>BRD-K75264577__NEU__trt_cp </td><td>-2.051050</td></tr>\n",
"\t<tr><th scope=row>BRD-K01477275__NPC__trt_cp</th><td>BRD-K01477275__NPC__trt_cp </td><td>-2.038408</td></tr>\n",
"\t<tr><th scope=row>BRD-K02519835__VCAP__trt_cp</th><td>BRD-K02519835__VCAP__trt_cp </td><td>-2.148807</td></tr>\n",
"\t<tr><th scope=row>motesanib__HS578T__trt_cp</th><td>motesanib__HS578T__trt_cp </td><td>-2.047123</td></tr>\n",
"\t<tr><th scope=row>SYK-inhibitor__SKBR3__trt_cp</th><td>SYK-inhibitor__SKBR3__trt_cp </td><td>-2.655849</td></tr>\n",
"\t<tr><th scope=row>ENMD-2076__A375__trt_cp</th><td>ENMD-2076__A375__trt_cp </td><td>-2.061680</td></tr>\n",
"\t<tr><th scope=row>BRD-K99636700__HCC515__trt_cp</th><td>BRD-K99636700__HCC515__trt_cp </td><td>-2.166222</td></tr>\n",
"\t<tr><th scope=row>apicidin__HEPG2__trt_cp</th><td>apicidin__HEPG2__trt_cp </td><td>-2.335700</td></tr>\n",
"\t<tr><th scope=row>avrainvillamide-analog-4__MCF7__trt_cp</th><td>avrainvillamide-analog-4__MCF7__trt_cp</td><td>-2.152519</td></tr>\n",
"</tbody>\n",
"</table>\n",
"</dd>\n",
"</dl>\n"
],
"text/latex": [
"\\begin{description}\n",
"\\item[\\$VENTX] A data.frame: 80 × 2\n",
"\\begin{tabular}{r|ll}\n",
" & drug & zscore\\\\\n",
" & <chr> & <dbl>\\\\\n",
"\\hline\n",
"\tbutoconazole\\_\\_HCC515\\_\\_trt\\_cp & butoconazole\\_\\_HCC515\\_\\_trt\\_cp & -2.043097\\\\\n",
"\tamcinonide\\_\\_VCAP\\_\\_trt\\_cp & amcinonide\\_\\_VCAP\\_\\_trt\\_cp & -2.013700\\\\\n",
"\tverteporfin\\_\\_VCAP\\_\\_trt\\_cp & verteporfin\\_\\_VCAP\\_\\_trt\\_cp & -2.372383\\\\\n",
"\tnapelline\\_\\_HT29\\_\\_trt\\_cp & napelline\\_\\_HT29\\_\\_trt\\_cp & -2.024536\\\\\n",
"\tclioquinol\\_\\_HT29\\_\\_trt\\_cp & clioquinol\\_\\_HT29\\_\\_trt\\_cp & -2.086267\\\\\n",
"\tNS-3694\\_\\_VCAP\\_\\_trt\\_cp & NS-3694\\_\\_VCAP\\_\\_trt\\_cp & -2.178900\\\\\n",
"\tAS-605240\\_\\_VCAP\\_\\_trt\\_cp & AS-605240\\_\\_VCAP\\_\\_trt\\_cp & -2.451528\\\\\n",
"\tSJ-172550\\_\\_VCAP\\_\\_trt\\_cp & SJ-172550\\_\\_VCAP\\_\\_trt\\_cp & -2.893954\\\\\n",
"\tJAS07-005\\_\\_VCAP\\_\\_trt\\_cp & JAS07-005\\_\\_VCAP\\_\\_trt\\_cp & -2.086582\\\\\n",
"\tBRD-A38425832\\_\\_MCF7\\_\\_trt\\_cp & BRD-A38425832\\_\\_MCF7\\_\\_trt\\_cp & -2.438600\\\\\n",
"\tBRD-K32827536\\_\\_PC3\\_\\_trt\\_cp & BRD-K32827536\\_\\_PC3\\_\\_trt\\_cp & -2.027371\\\\\n",
"\tBRD-K48844671\\_\\_PC3\\_\\_trt\\_cp & BRD-K48844671\\_\\_PC3\\_\\_trt\\_cp & -2.115793\\\\\n",
"\tBRD-K23165181\\_\\_VCAP\\_\\_trt\\_cp & BRD-K23165181\\_\\_VCAP\\_\\_trt\\_cp & -2.151439\\\\\n",
"\tBRD-K58247702\\_\\_VCAP\\_\\_trt\\_cp & BRD-K58247702\\_\\_VCAP\\_\\_trt\\_cp & -2.014121\\\\\n",
"\tBRD-K70917163\\_\\_VCAP\\_\\_trt\\_cp & BRD-K70917163\\_\\_VCAP\\_\\_trt\\_cp & -2.195663\\\\\n",
"\tKU-C104140\\_\\_A549\\_\\_trt\\_cp & KU-C104140\\_\\_A549\\_\\_trt\\_cp & -2.076100\\\\\n",
"\tBRD-A11095214\\_\\_MCF7\\_\\_trt\\_cp & BRD-A11095214\\_\\_MCF7\\_\\_trt\\_cp & -2.200500\\\\\n",
"\tBRD-K33182644\\_\\_MCF7\\_\\_trt\\_cp & BRD-K33182644\\_\\_MCF7\\_\\_trt\\_cp & -2.137250\\\\\n",
"\tBRD-K98991361\\_\\_A549\\_\\_trt\\_cp & BRD-K98991361\\_\\_A549\\_\\_trt\\_cp & -2.161300\\\\\n",
"\toxcarbazepine\\_\\_MCF7\\_\\_trt\\_cp & oxcarbazepine\\_\\_MCF7\\_\\_trt\\_cp & -2.080350\\\\\n",
"\tlansoprazole\\_\\_VCAP\\_\\_trt\\_cp & lansoprazole\\_\\_VCAP\\_\\_trt\\_cp & -2.672177\\\\\n",
"\tkitasamycin\\_\\_VCAP\\_\\_trt\\_cp & kitasamycin\\_\\_VCAP\\_\\_trt\\_cp & -2.771939\\\\\n",
"\tBRD-A16581344\\_\\_A549\\_\\_trt\\_cp & BRD-A16581344\\_\\_A549\\_\\_trt\\_cp & -2.207200\\\\\n",
"\tBRD-K88556033\\_\\_A549\\_\\_trt\\_cp & BRD-K88556033\\_\\_A549\\_\\_trt\\_cp & -2.038800\\\\\n",
"\tRAN-27\\_\\_NEU\\_\\_trt\\_cp & RAN-27\\_\\_NEU\\_\\_trt\\_cp & -2.076294\\\\\n",
"\tBRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & -2.608974\\\\\n",
"\tBRD-K58279162\\_\\_NEU\\_\\_trt\\_cp & BRD-K58279162\\_\\_NEU\\_\\_trt\\_cp & -2.688838\\\\\n",
"\tBRD-K14316227\\_\\_NPC\\_\\_trt\\_cp & BRD-K14316227\\_\\_NPC\\_\\_trt\\_cp & -2.204158\\\\\n",
"\ttreprostinil\\_\\_PHH\\_\\_trt\\_cp & treprostinil\\_\\_PHH\\_\\_trt\\_cp & -2.756694\\\\\n",
"\tBRD-K82971429\\_\\_PHH\\_\\_trt\\_cp & BRD-K82971429\\_\\_PHH\\_\\_trt\\_cp & -2.028831\\\\\n",
"\t⋮ & ⋮ & ⋮\\\\\n",
"\tNSC-663284\\_\\_PHH\\_\\_trt\\_cp & NSC-663284\\_\\_PHH\\_\\_trt\\_cp & -2.211250\\\\\n",
"\tzoxazolamine\\_\\_PHH\\_\\_trt\\_cp & zoxazolamine\\_\\_PHH\\_\\_trt\\_cp & -2.148100\\\\\n",
"\tnateglinide\\_\\_PHH\\_\\_trt\\_cp & nateglinide\\_\\_PHH\\_\\_trt\\_cp & -2.026000\\\\\n",
"\tLFM-A13\\_\\_NEU\\_\\_trt\\_cp & LFM-A13\\_\\_NEU\\_\\_trt\\_cp & -2.864500\\\\\n",
"\tBML-257\\_\\_NEU\\_\\_trt\\_cp & BML-257\\_\\_NEU\\_\\_trt\\_cp & -3.350300\\\\\n",
"\tlamotrigine\\_\\_NEU\\_\\_trt\\_cp & lamotrigine\\_\\_NEU\\_\\_trt\\_cp & -2.059334\\\\\n",
"\tIC-261\\_\\_PHH\\_\\_trt\\_cp & IC-261\\_\\_PHH\\_\\_trt\\_cp & -2.089171\\\\\n",
"\tL-701252\\_\\_PHH\\_\\_trt\\_cp & L-701252\\_\\_PHH\\_\\_trt\\_cp & -3.265500\\\\\n",
"\tmometasone\\_\\_PHH\\_\\_trt\\_cp & mometasone\\_\\_PHH\\_\\_trt\\_cp & -2.173689\\\\\n",
"\tscoulerine\\_\\_PHH\\_\\_trt\\_cp & scoulerine\\_\\_PHH\\_\\_trt\\_cp & -2.078122\\\\\n",
"\tdihydroergotamine\\_\\_PHH\\_\\_trt\\_cp & dihydroergotamine\\_\\_PHH\\_\\_trt\\_cp & -2.580976\\\\\n",
"\tdipyridamole\\_\\_PHH\\_\\_trt\\_cp & dipyridamole\\_\\_PHH\\_\\_trt\\_cp & -2.045686\\\\\n",
"\ttyrphostin-AG-825\\_\\_MCF7\\_\\_trt\\_cp & tyrphostin-AG-825\\_\\_MCF7\\_\\_trt\\_cp & -2.394913\\\\\n",
"\trosmarinic-acid\\_\\_NPC\\_\\_trt\\_cp & rosmarinic-acid\\_\\_NPC\\_\\_trt\\_cp & -2.170692\\\\\n",
"\tamthamine\\_\\_PHH\\_\\_trt\\_cp & amthamine\\_\\_PHH\\_\\_trt\\_cp & -2.258550\\\\\n",
"\tNAN-190\\_\\_PHH\\_\\_trt\\_cp & NAN-190\\_\\_PHH\\_\\_trt\\_cp & -4.584300\\\\\n",
"\tBRD-K24053449\\_\\_MCF7\\_\\_trt\\_cp & BRD-K24053449\\_\\_MCF7\\_\\_trt\\_cp & -2.124968\\\\\n",
"\tBRD-K88278225\\_\\_PC3\\_\\_trt\\_cp & BRD-K88278225\\_\\_PC3\\_\\_trt\\_cp & -5.143122\\\\\n",
"\tBRD-K03358980\\_\\_VCAP\\_\\_trt\\_cp & BRD-K03358980\\_\\_VCAP\\_\\_trt\\_cp & -2.230576\\\\\n",
"\tBRD-K06592610\\_\\_VCAP\\_\\_trt\\_cp & BRD-K06592610\\_\\_VCAP\\_\\_trt\\_cp & -2.063635\\\\\n",
"\tRDR-01440SC\\_\\_VCAP\\_\\_trt\\_cp & RDR-01440SC\\_\\_VCAP\\_\\_trt\\_cp & -2.042054\\\\\n",
"\tBRD-K76691125\\_\\_VCAP\\_\\_trt\\_cp & BRD-K76691125\\_\\_VCAP\\_\\_trt\\_cp & -2.113669\\\\\n",
"\ttubacin\\_\\_VCAP\\_\\_trt\\_cp & tubacin\\_\\_VCAP\\_\\_trt\\_cp & -3.499640\\\\\n",
"\tBRD-K47512679\\_\\_NPC\\_\\_trt\\_cp & BRD-K47512679\\_\\_NPC\\_\\_trt\\_cp & -2.032956\\\\\n",
"\tBRD-K05353139\\_\\_HT29\\_\\_trt\\_cp & BRD-K05353139\\_\\_HT29\\_\\_trt\\_cp & -2.013206\\\\\n",
"\tBRD-K48598367\\_\\_NEU\\_\\_trt\\_cp & BRD-K48598367\\_\\_NEU\\_\\_trt\\_cp & -2.556500\\\\\n",
"\tSA-419083\\_\\_NPC\\_\\_trt\\_cp & SA-419083\\_\\_NPC\\_\\_trt\\_cp & -2.028479\\\\\n",
"\tBRD-K28772322\\_\\_VCAP\\_\\_trt\\_cp & BRD-K28772322\\_\\_VCAP\\_\\_trt\\_cp & -2.263741\\\\\n",
"\tnocodazole\\_\\_FIBRNPC\\_\\_trt\\_cp & nocodazole\\_\\_FIBRNPC\\_\\_trt\\_cp & -2.172350\\\\\n",
"\tAVA\\_\\_HA1E\\_\\_trt\\_cp & AVA\\_\\_HA1E\\_\\_trt\\_cp & -2.028199\\\\\n",
"\\end{tabular}\n",
"\n",
"\\item[\\$ISL1] A data.frame: 197 × 2\n",
"\\begin{tabular}{r|ll}\n",
" & drug & zscore\\\\\n",
" & <chr> & <dbl>\\\\\n",
"\\hline\n",
"\tBRD-K26684619\\_\\_CD34\\_\\_trt\\_cp & BRD-K26684619\\_\\_CD34\\_\\_trt\\_cp & -2.040950\\\\\n",
"\tBRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & -2.227154\\\\\n",
"\tMRS-1845\\_\\_HCC515\\_\\_trt\\_cp & MRS-1845\\_\\_HCC515\\_\\_trt\\_cp & -2.417191\\\\\n",
"\tmelperone\\_\\_HCC515\\_\\_trt\\_cp & melperone\\_\\_HCC515\\_\\_trt\\_cp & -2.385237\\\\\n",
"\tFCCP\\_\\_HCC515\\_\\_trt\\_cp & FCCP\\_\\_HCC515\\_\\_trt\\_cp & -2.176191\\\\\n",
"\tBCL2-inhibitor\\_\\_VCAP\\_\\_trt\\_cp & BCL2-inhibitor\\_\\_VCAP\\_\\_trt\\_cp & -2.520154\\\\\n",
"\tubenimex\\_\\_VCAP\\_\\_trt\\_cp & ubenimex\\_\\_VCAP\\_\\_trt\\_cp & -2.167702\\\\\n",
"\tepitestosterone\\_\\_VCAP\\_\\_trt\\_cp & epitestosterone\\_\\_VCAP\\_\\_trt\\_cp & -2.142600\\\\\n",
"\tprocainamide\\_\\_VCAP\\_\\_trt\\_cp & procainamide\\_\\_VCAP\\_\\_trt\\_cp & -2.136900\\\\\n",
"\tanagrelide\\_\\_HA1E\\_\\_trt\\_cp & anagrelide\\_\\_HA1E\\_\\_trt\\_cp & -2.888882\\\\\n",
"\tbithionol\\_\\_HCC515\\_\\_trt\\_cp & bithionol\\_\\_HCC515\\_\\_trt\\_cp & -2.335168\\\\\n",
"\tGW-1929\\_\\_VCAP\\_\\_trt\\_cp & GW-1929\\_\\_VCAP\\_\\_trt\\_cp & -3.890623\\\\\n",
"\tCMPD-1\\_\\_A375\\_\\_trt\\_cp & CMPD-1\\_\\_A375\\_\\_trt\\_cp & -2.118605\\\\\n",
"\tST-638\\_\\_HA1E\\_\\_trt\\_cp & ST-638\\_\\_HA1E\\_\\_trt\\_cp & -2.139165\\\\\n",
"\tfluocinolone-acetonide\\_\\_HT29\\_\\_trt\\_cp & fluocinolone-acetonide\\_\\_HT29\\_\\_trt\\_cp & -2.311850\\\\\n",
"\tmitoxantrone\\_\\_HT29\\_\\_trt\\_cp & mitoxantrone\\_\\_HT29\\_\\_trt\\_cp & -2.173384\\\\\n",
"\tL-168049\\_\\_VCAP\\_\\_trt\\_cp & L-168049\\_\\_VCAP\\_\\_trt\\_cp & -2.498789\\\\\n",
"\tBX-795\\_\\_HT29\\_\\_trt\\_cp & BX-795\\_\\_HT29\\_\\_trt\\_cp & -2.146887\\\\\n",
"\tcucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & -2.131572\\\\\n",
"\tCT-200783\\_\\_VCAP\\_\\_trt\\_cp & CT-200783\\_\\_VCAP\\_\\_trt\\_cp & -2.346538\\\\\n",
"\tBRD-K60870698\\_\\_A375\\_\\_trt\\_cp & BRD-K60870698\\_\\_A375\\_\\_trt\\_cp & -2.611861\\\\\n",
"\tBRD-K84203638\\_\\_A375\\_\\_trt\\_cp & BRD-K84203638\\_\\_A375\\_\\_trt\\_cp & -2.241982\\\\\n",
"\tBRD-K05153001\\_\\_A549\\_\\_trt\\_cp & BRD-K05153001\\_\\_A549\\_\\_trt\\_cp & -2.140815\\\\\n",
"\tBRD-K85275009\\_\\_A549\\_\\_trt\\_cp & BRD-K85275009\\_\\_A549\\_\\_trt\\_cp & -4.711900\\\\\n",
"\tBRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & -2.309873\\\\\n",
"\tBRD-A58924247\\_\\_HT29\\_\\_trt\\_cp & BRD-A58924247\\_\\_HT29\\_\\_trt\\_cp & -2.229404\\\\\n",
"\tBRD-K91691979\\_\\_PC3\\_\\_trt\\_cp & BRD-K91691979\\_\\_PC3\\_\\_trt\\_cp & -2.309459\\\\\n",
"\tBRD-K19735876\\_\\_A375\\_\\_trt\\_cp & BRD-K19735876\\_\\_A375\\_\\_trt\\_cp & -2.083350\\\\\n",
"\tBRD-A21406558\\_\\_MCF7\\_\\_trt\\_cp & BRD-A21406558\\_\\_MCF7\\_\\_trt\\_cp & -2.156250\\\\\n",
"\tBRD-K07259155\\_\\_MCF7\\_\\_trt\\_cp & BRD-K07259155\\_\\_MCF7\\_\\_trt\\_cp & -2.299050\\\\\n",
"\t⋮ & ⋮ & ⋮\\\\\n",
"\tSR-12813\\_\\_NEU\\_\\_trt\\_cp & SR-12813\\_\\_NEU\\_\\_trt\\_cp & -2.061450\\\\\n",
"\tLBH-589\\_\\_NEU\\_\\_trt\\_cp & LBH-589\\_\\_NEU\\_\\_trt\\_cp & -2.051542\\\\\n",
"\tBG-1003\\_\\_NPC\\_\\_trt\\_cp & BG-1003\\_\\_NPC\\_\\_trt\\_cp & -2.050464\\\\\n",
"\tLBH-589\\_\\_NPC\\_\\_trt\\_cp & LBH-589\\_\\_NPC\\_\\_trt\\_cp & -2.351810\\\\\n",
"\tBG-1008\\_\\_NEU\\_\\_trt\\_cp & BG-1008\\_\\_NEU\\_\\_trt\\_cp & -2.506527\\\\\n",
"\ttemozolomide\\_\\_NEU\\_\\_trt\\_cp & temozolomide\\_\\_NEU\\_\\_trt\\_cp & -2.358148\\\\\n",
"\tBG-1005\\_\\_NEU\\_\\_trt\\_cp & BG-1005\\_\\_NEU\\_\\_trt\\_cp & -2.408175\\\\\n",
"\tBG-1025\\_\\_NEU\\_\\_trt\\_cp & BG-1025\\_\\_NEU\\_\\_trt\\_cp & -2.330200\\\\\n",
"\tC2-dihydroceramide\\_\\_NEU\\_\\_trt\\_cp & C2-dihydroceramide\\_\\_NEU\\_\\_trt\\_cp & -2.060200\\\\\n",
"\tBG-1030\\_\\_NEU\\_\\_trt\\_cp & BG-1030\\_\\_NEU\\_\\_trt\\_cp & -2.047566\\\\\n",
"\toxamflatin\\_\\_NPC\\_\\_trt\\_cp & oxamflatin\\_\\_NPC\\_\\_trt\\_cp & -2.670142\\\\\n",
"\tBG-1029\\_\\_NPC\\_\\_trt\\_cp & BG-1029\\_\\_NPC\\_\\_trt\\_cp & -2.168213\\\\\n",
"\tBG-1006\\_\\_NPC\\_\\_trt\\_cp & BG-1006\\_\\_NPC\\_\\_trt\\_cp & -2.664152\\\\\n",
"\tBML-284\\_\\_NPC\\_\\_trt\\_cp & BML-284\\_\\_NPC\\_\\_trt\\_cp & -4.036828\\\\\n",
"\tM-344\\_\\_NPC\\_\\_trt\\_cp & M-344\\_\\_NPC\\_\\_trt\\_cp & -2.041860\\\\\n",
"\tBG-1025\\_\\_NPC\\_\\_trt\\_cp & BG-1025\\_\\_NPC\\_\\_trt\\_cp & -2.107575\\\\\n",
"\tBG-1026\\_\\_NPC\\_\\_trt\\_cp & BG-1026\\_\\_NPC\\_\\_trt\\_cp & -2.440128\\\\\n",
"\tNCH-51\\_\\_NPC\\_\\_trt\\_cp & NCH-51\\_\\_NPC\\_\\_trt\\_cp & -2.122013\\\\\n",
"\tBG-1007\\_\\_NPC\\_\\_trt\\_cp & BG-1007\\_\\_NPC\\_\\_trt\\_cp & -2.229874\\\\\n",
"\tBG-1028\\_\\_NPC\\_\\_trt\\_cp & BG-1028\\_\\_NPC\\_\\_trt\\_cp & -2.391268\\\\\n",
"\tBG-1027\\_\\_NPC\\_\\_trt\\_cp & BG-1027\\_\\_NPC\\_\\_trt\\_cp & -2.334610\\\\\n",
"\ttert-butylhydroquinone\\_\\_MCF7\\_\\_trt\\_cp & tert-butylhydroquinone\\_\\_MCF7\\_\\_trt\\_cp & -3.080953\\\\\n",
"\tpanobinostat\\_\\_A375\\_\\_trt\\_cp & panobinostat\\_\\_A375\\_\\_trt\\_cp & -2.063759\\\\\n",
"\tstaurosporine\\_\\_A375\\_\\_trt\\_cp & staurosporine\\_\\_A375\\_\\_trt\\_cp & -3.507200\\\\\n",
"\tapicidin\\_\\_A375\\_\\_trt\\_cp & apicidin\\_\\_A375\\_\\_trt\\_cp & -2.681550\\\\\n",
"\tBRD-K57064803\\_\\_MCF7\\_\\_trt\\_cp & BRD-K57064803\\_\\_MCF7\\_\\_trt\\_cp & -2.356925\\\\\n",
"\talpha-tocopherol\\_\\_MCF7\\_\\_trt\\_cp & alpha-tocopherol\\_\\_MCF7\\_\\_trt\\_cp & -2.502400\\\\\n",
"\tJMW-MITF1\\_\\_MCF7\\_\\_trt\\_cp & JMW-MITF1\\_\\_MCF7\\_\\_trt\\_cp & -2.199600\\\\\n",
"\talpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & -2.310900\\\\\n",
"\tbortezomib\\_\\_PC3\\_\\_trt\\_cp & bortezomib\\_\\_PC3\\_\\_trt\\_cp & -3.855000\\\\\n",
"\\end{tabular}\n",
"\n",
"\\item[\\$HOXC5] A data.frame: 49 × 2\n",
"\\begin{tabular}{r|ll}\n",
" & drug & zscore\\\\\n",
" & <chr> & <dbl>\\\\\n",
"\\hline\n",
"\taminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & -2.349426\\\\\n",
"\tARP-101\\_\\_HA1E\\_\\_trt\\_cp & ARP-101\\_\\_HA1E\\_\\_trt\\_cp & -2.420850\\\\\n",
"\thomoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & -2.545411\\\\\n",
"\tCFM-1571\\_\\_HCC515\\_\\_trt\\_cp & CFM-1571\\_\\_HCC515\\_\\_trt\\_cp & -2.027797\\\\\n",
"\tapoptosis-activator-II\\_\\_HCC515\\_\\_trt\\_cp & apoptosis-activator-II\\_\\_HCC515\\_\\_trt\\_cp & -2.027338\\\\\n",
"\tpuromycin\\_\\_VCAP\\_\\_trt\\_cp & puromycin\\_\\_VCAP\\_\\_trt\\_cp & -3.208967\\\\\n",
"\tNSC-632839\\_\\_VCAP\\_\\_trt\\_cp & NSC-632839\\_\\_VCAP\\_\\_trt\\_cp & -2.437900\\\\\n",
"\tNNC-711\\_\\_VCAP\\_\\_trt\\_cp & NNC-711\\_\\_VCAP\\_\\_trt\\_cp & -2.587158\\\\\n",
"\tMG-132\\_\\_VCAP\\_\\_trt\\_cp & MG-132\\_\\_VCAP\\_\\_trt\\_cp & -2.497801\\\\\n",
"\tRo-15-4513\\_\\_VCAP\\_\\_trt\\_cp & Ro-15-4513\\_\\_VCAP\\_\\_trt\\_cp & -2.462467\\\\\n",
"\tR-59022\\_\\_HA1E\\_\\_trt\\_cp & R-59022\\_\\_HA1E\\_\\_trt\\_cp & -2.440392\\\\\n",
"\tcucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & -2.504937\\\\\n",
"\tSCH-79797\\_\\_MCF7\\_\\_trt\\_cp & SCH-79797\\_\\_MCF7\\_\\_trt\\_cp & -3.103155\\\\\n",
"\tBRD-K19290969\\_\\_A549\\_\\_trt\\_cp & BRD-K19290969\\_\\_A549\\_\\_trt\\_cp & -2.442208\\\\\n",
"\tBIX-02188\\_\\_VCAP\\_\\_trt\\_cp & BIX-02188\\_\\_VCAP\\_\\_trt\\_cp & -2.021193\\\\\n",
"\tBRD-A98444709\\_\\_A549\\_\\_trt\\_cp & BRD-A98444709\\_\\_A549\\_\\_trt\\_cp & -2.181950\\\\\n",
"\tBRD-K18726304\\_\\_MCF7\\_\\_trt\\_cp & BRD-K18726304\\_\\_MCF7\\_\\_trt\\_cp & -2.498750\\\\\n",
"\ttoremifene\\_\\_MCF7\\_\\_trt\\_cp & toremifene\\_\\_MCF7\\_\\_trt\\_cp & -2.111762\\\\\n",
"\tBRD-K32896438\\_\\_MCF7\\_\\_trt\\_cp & BRD-K32896438\\_\\_MCF7\\_\\_trt\\_cp & -2.568452\\\\\n",
"\tRAN-27\\_\\_NEU\\_\\_trt\\_cp & RAN-27\\_\\_NEU\\_\\_trt\\_cp & -2.057970\\\\\n",
"\tBRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & -2.403568\\\\\n",
"\tcytochalasin-d\\_\\_MCF7\\_\\_trt\\_cp & cytochalasin-d\\_\\_MCF7\\_\\_trt\\_cp & -2.524929\\\\\n",
"\tST-4029010\\_\\_NEU\\_\\_trt\\_cp & ST-4029010\\_\\_NEU\\_\\_trt\\_cp & -2.160550\\\\\n",
"\tsorafenib\\_\\_VCAP\\_\\_trt\\_cp & sorafenib\\_\\_VCAP\\_\\_trt\\_cp & -2.387828\\\\\n",
"\tBG-FA-0953\\_\\_VCAP\\_\\_trt\\_cp & BG-FA-0953\\_\\_VCAP\\_\\_trt\\_cp & -2.010978\\\\\n",
"\tWYE-354\\_\\_ASC\\_\\_trt\\_cp & WYE-354\\_\\_ASC\\_\\_trt\\_cp & -2.030976\\\\\n",
"\tWYE-125132\\_\\_MCF7\\_\\_trt\\_cp & WYE-125132\\_\\_MCF7\\_\\_trt\\_cp & -2.019033\\\\\n",
"\tverrucarin-a\\_\\_NEU\\_\\_trt\\_cp & verrucarin-a\\_\\_NEU\\_\\_trt\\_cp & -2.535550\\\\\n",
"\tmirin\\_\\_VCAP\\_\\_trt\\_cp & mirin\\_\\_VCAP\\_\\_trt\\_cp & -2.051119\\\\\n",
"\tCGP-71683\\_\\_MCF7\\_\\_trt\\_cp & CGP-71683\\_\\_MCF7\\_\\_trt\\_cp & -2.191356\\\\\n",
"\tNSC-663284\\_\\_PHH\\_\\_trt\\_cp & NSC-663284\\_\\_PHH\\_\\_trt\\_cp & -2.232050\\\\\n",
"\tproadifen\\_\\_ASC\\_\\_trt\\_cp & proadifen\\_\\_ASC\\_\\_trt\\_cp & -2.171099\\\\\n",
"\tanisomycin\\_\\_NEU\\_\\_trt\\_cp & anisomycin\\_\\_NEU\\_\\_trt\\_cp & -2.530992\\\\\n",
"\tformoterol\\_\\_SKB\\_\\_trt\\_cp & formoterol\\_\\_SKB\\_\\_trt\\_cp & -2.052984\\\\\n",
"\tFCCP\\_\\_MCF7\\_\\_trt\\_cp & FCCP\\_\\_MCF7\\_\\_trt\\_cp & -2.068842\\\\\n",
"\tdiphenyleneiodonium\\_\\_MCF7\\_\\_trt\\_cp & diphenyleneiodonium\\_\\_MCF7\\_\\_trt\\_cp & -2.738179\\\\\n",
"\tNSC-94258\\_\\_MCF7\\_\\_trt\\_cp & NSC-94258\\_\\_MCF7\\_\\_trt\\_cp & -2.348442\\\\\n",
"\tSQ-22536\\_\\_NPC\\_\\_trt\\_cp & SQ-22536\\_\\_NPC\\_\\_trt\\_cp & -2.024650\\\\\n",
"\tpyrvinium\\_\\_MCF7\\_\\_trt\\_cp & pyrvinium\\_\\_MCF7\\_\\_trt\\_cp & -2.287450\\\\\n",
"\tBRD-K00835201\\_\\_NEU\\_\\_trt\\_cp & BRD-K00835201\\_\\_NEU\\_\\_trt\\_cp & -2.013800\\\\\n",
"\tBRD-K75264577\\_\\_NEU\\_\\_trt\\_cp & BRD-K75264577\\_\\_NEU\\_\\_trt\\_cp & -2.051050\\\\\n",
"\tBRD-K01477275\\_\\_NPC\\_\\_trt\\_cp & BRD-K01477275\\_\\_NPC\\_\\_trt\\_cp & -2.038408\\\\\n",
"\tBRD-K02519835\\_\\_VCAP\\_\\_trt\\_cp & BRD-K02519835\\_\\_VCAP\\_\\_trt\\_cp & -2.148807\\\\\n",
"\tmotesanib\\_\\_HS578T\\_\\_trt\\_cp & motesanib\\_\\_HS578T\\_\\_trt\\_cp & -2.047123\\\\\n",
"\tSYK-inhibitor\\_\\_SKBR3\\_\\_trt\\_cp & SYK-inhibitor\\_\\_SKBR3\\_\\_trt\\_cp & -2.655849\\\\\n",
"\tENMD-2076\\_\\_A375\\_\\_trt\\_cp & ENMD-2076\\_\\_A375\\_\\_trt\\_cp & -2.061680\\\\\n",
"\tBRD-K99636700\\_\\_HCC515\\_\\_trt\\_cp & BRD-K99636700\\_\\_HCC515\\_\\_trt\\_cp & -2.166222\\\\\n",
"\tapicidin\\_\\_HEPG2\\_\\_trt\\_cp & apicidin\\_\\_HEPG2\\_\\_trt\\_cp & -2.335700\\\\\n",
"\tavrainvillamide-analog-4\\_\\_MCF7\\_\\_trt\\_cp & avrainvillamide-analog-4\\_\\_MCF7\\_\\_trt\\_cp & -2.152519\\\\\n",
"\\end{tabular}\n",
"\n",
"\\end{description}\n"
],
"text/markdown": [
"$VENTX\n",
": \n",
"A data.frame: 80 × 2\n",
"\n",
"| <!--/--> | drug <chr> | zscore <dbl> |\n",
"|---|---|---|\n",
"| butoconazole__HCC515__trt_cp | butoconazole__HCC515__trt_cp | -2.043097 |\n",
"| amcinonide__VCAP__trt_cp | amcinonide__VCAP__trt_cp | -2.013700 |\n",
"| verteporfin__VCAP__trt_cp | verteporfin__VCAP__trt_cp | -2.372383 |\n",
"| napelline__HT29__trt_cp | napelline__HT29__trt_cp | -2.024536 |\n",
"| clioquinol__HT29__trt_cp | clioquinol__HT29__trt_cp | -2.086267 |\n",
"| NS-3694__VCAP__trt_cp | NS-3694__VCAP__trt_cp | -2.178900 |\n",
"| AS-605240__VCAP__trt_cp | AS-605240__VCAP__trt_cp | -2.451528 |\n",
"| SJ-172550__VCAP__trt_cp | SJ-172550__VCAP__trt_cp | -2.893954 |\n",
"| JAS07-005__VCAP__trt_cp | JAS07-005__VCAP__trt_cp | -2.086582 |\n",
"| BRD-A38425832__MCF7__trt_cp | BRD-A38425832__MCF7__trt_cp | -2.438600 |\n",
"| BRD-K32827536__PC3__trt_cp | BRD-K32827536__PC3__trt_cp | -2.027371 |\n",
"| BRD-K48844671__PC3__trt_cp | BRD-K48844671__PC3__trt_cp | -2.115793 |\n",
"| BRD-K23165181__VCAP__trt_cp | BRD-K23165181__VCAP__trt_cp | -2.151439 |\n",
"| BRD-K58247702__VCAP__trt_cp | BRD-K58247702__VCAP__trt_cp | -2.014121 |\n",
"| BRD-K70917163__VCAP__trt_cp | BRD-K70917163__VCAP__trt_cp | -2.195663 |\n",
"| KU-C104140__A549__trt_cp | KU-C104140__A549__trt_cp | -2.076100 |\n",
"| BRD-A11095214__MCF7__trt_cp | BRD-A11095214__MCF7__trt_cp | -2.200500 |\n",
"| BRD-K33182644__MCF7__trt_cp | BRD-K33182644__MCF7__trt_cp | -2.137250 |\n",
"| BRD-K98991361__A549__trt_cp | BRD-K98991361__A549__trt_cp | -2.161300 |\n",
"| oxcarbazepine__MCF7__trt_cp | oxcarbazepine__MCF7__trt_cp | -2.080350 |\n",
"| lansoprazole__VCAP__trt_cp | lansoprazole__VCAP__trt_cp | -2.672177 |\n",
"| kitasamycin__VCAP__trt_cp | kitasamycin__VCAP__trt_cp | -2.771939 |\n",
"| BRD-A16581344__A549__trt_cp | BRD-A16581344__A549__trt_cp | -2.207200 |\n",
"| BRD-K88556033__A549__trt_cp | BRD-K88556033__A549__trt_cp | -2.038800 |\n",
"| RAN-27__NEU__trt_cp | RAN-27__NEU__trt_cp | -2.076294 |\n",
"| BRD-K44893543__NEU__trt_cp | BRD-K44893543__NEU__trt_cp | -2.608974 |\n",
"| BRD-K58279162__NEU__trt_cp | BRD-K58279162__NEU__trt_cp | -2.688838 |\n",
"| BRD-K14316227__NPC__trt_cp | BRD-K14316227__NPC__trt_cp | -2.204158 |\n",
"| treprostinil__PHH__trt_cp | treprostinil__PHH__trt_cp | -2.756694 |\n",
"| BRD-K82971429__PHH__trt_cp | BRD-K82971429__PHH__trt_cp | -2.028831 |\n",
"| ⋮ | ⋮ | ⋮ |\n",
"| NSC-663284__PHH__trt_cp | NSC-663284__PHH__trt_cp | -2.211250 |\n",
"| zoxazolamine__PHH__trt_cp | zoxazolamine__PHH__trt_cp | -2.148100 |\n",
"| nateglinide__PHH__trt_cp | nateglinide__PHH__trt_cp | -2.026000 |\n",
"| LFM-A13__NEU__trt_cp | LFM-A13__NEU__trt_cp | -2.864500 |\n",
"| BML-257__NEU__trt_cp | BML-257__NEU__trt_cp | -3.350300 |\n",
"| lamotrigine__NEU__trt_cp | lamotrigine__NEU__trt_cp | -2.059334 |\n",
"| IC-261__PHH__trt_cp | IC-261__PHH__trt_cp | -2.089171 |\n",
"| L-701252__PHH__trt_cp | L-701252__PHH__trt_cp | -3.265500 |\n",
"| mometasone__PHH__trt_cp | mometasone__PHH__trt_cp | -2.173689 |\n",
"| scoulerine__PHH__trt_cp | scoulerine__PHH__trt_cp | -2.078122 |\n",
"| dihydroergotamine__PHH__trt_cp | dihydroergotamine__PHH__trt_cp | -2.580976 |\n",
"| dipyridamole__PHH__trt_cp | dipyridamole__PHH__trt_cp | -2.045686 |\n",
"| tyrphostin-AG-825__MCF7__trt_cp | tyrphostin-AG-825__MCF7__trt_cp | -2.394913 |\n",
"| rosmarinic-acid__NPC__trt_cp | rosmarinic-acid__NPC__trt_cp | -2.170692 |\n",
"| amthamine__PHH__trt_cp | amthamine__PHH__trt_cp | -2.258550 |\n",
"| NAN-190__PHH__trt_cp | NAN-190__PHH__trt_cp | -4.584300 |\n",
"| BRD-K24053449__MCF7__trt_cp | BRD-K24053449__MCF7__trt_cp | -2.124968 |\n",
"| BRD-K88278225__PC3__trt_cp | BRD-K88278225__PC3__trt_cp | -5.143122 |\n",
"| BRD-K03358980__VCAP__trt_cp | BRD-K03358980__VCAP__trt_cp | -2.230576 |\n",
"| BRD-K06592610__VCAP__trt_cp | BRD-K06592610__VCAP__trt_cp | -2.063635 |\n",
"| RDR-01440SC__VCAP__trt_cp | RDR-01440SC__VCAP__trt_cp | -2.042054 |\n",
"| BRD-K76691125__VCAP__trt_cp | BRD-K76691125__VCAP__trt_cp | -2.113669 |\n",
"| tubacin__VCAP__trt_cp | tubacin__VCAP__trt_cp | -3.499640 |\n",
"| BRD-K47512679__NPC__trt_cp | BRD-K47512679__NPC__trt_cp | -2.032956 |\n",
"| BRD-K05353139__HT29__trt_cp | BRD-K05353139__HT29__trt_cp | -2.013206 |\n",
"| BRD-K48598367__NEU__trt_cp | BRD-K48598367__NEU__trt_cp | -2.556500 |\n",
"| SA-419083__NPC__trt_cp | SA-419083__NPC__trt_cp | -2.028479 |\n",
"| BRD-K28772322__VCAP__trt_cp | BRD-K28772322__VCAP__trt_cp | -2.263741 |\n",
"| nocodazole__FIBRNPC__trt_cp | nocodazole__FIBRNPC__trt_cp | -2.172350 |\n",
"| AVA__HA1E__trt_cp | AVA__HA1E__trt_cp | -2.028199 |\n",
"\n",
"\n",
"$ISL1\n",
": \n",
"A data.frame: 197 × 2\n",
"\n",
"| <!--/--> | drug <chr> | zscore <dbl> |\n",
"|---|---|---|\n",
"| BRD-K26684619__CD34__trt_cp | BRD-K26684619__CD34__trt_cp | -2.040950 |\n",
"| BRD-A51929314__HA1E__trt_cp | BRD-A51929314__HA1E__trt_cp | -2.227154 |\n",
"| MRS-1845__HCC515__trt_cp | MRS-1845__HCC515__trt_cp | -2.417191 |\n",
"| melperone__HCC515__trt_cp | melperone__HCC515__trt_cp | -2.385237 |\n",
"| FCCP__HCC515__trt_cp | FCCP__HCC515__trt_cp | -2.176191 |\n",
"| BCL2-inhibitor__VCAP__trt_cp | BCL2-inhibitor__VCAP__trt_cp | -2.520154 |\n",
"| ubenimex__VCAP__trt_cp | ubenimex__VCAP__trt_cp | -2.167702 |\n",
"| epitestosterone__VCAP__trt_cp | epitestosterone__VCAP__trt_cp | -2.142600 |\n",
"| procainamide__VCAP__trt_cp | procainamide__VCAP__trt_cp | -2.136900 |\n",
"| anagrelide__HA1E__trt_cp | anagrelide__HA1E__trt_cp | -2.888882 |\n",
"| bithionol__HCC515__trt_cp | bithionol__HCC515__trt_cp | -2.335168 |\n",
"| GW-1929__VCAP__trt_cp | GW-1929__VCAP__trt_cp | -3.890623 |\n",
"| CMPD-1__A375__trt_cp | CMPD-1__A375__trt_cp | -2.118605 |\n",
"| ST-638__HA1E__trt_cp | ST-638__HA1E__trt_cp | -2.139165 |\n",
"| fluocinolone-acetonide__HT29__trt_cp | fluocinolone-acetonide__HT29__trt_cp | -2.311850 |\n",
"| mitoxantrone__HT29__trt_cp | mitoxantrone__HT29__trt_cp | -2.173384 |\n",
"| L-168049__VCAP__trt_cp | L-168049__VCAP__trt_cp | -2.498789 |\n",
"| BX-795__HT29__trt_cp | BX-795__HT29__trt_cp | -2.146887 |\n",
"| cucurbitacin-i__MCF7__trt_cp | cucurbitacin-i__MCF7__trt_cp | -2.131572 |\n",
"| CT-200783__VCAP__trt_cp | CT-200783__VCAP__trt_cp | -2.346538 |\n",
"| BRD-K60870698__A375__trt_cp | BRD-K60870698__A375__trt_cp | -2.611861 |\n",
"| BRD-K84203638__A375__trt_cp | BRD-K84203638__A375__trt_cp | -2.241982 |\n",
"| BRD-K05153001__A549__trt_cp | BRD-K05153001__A549__trt_cp | -2.140815 |\n",
"| BRD-K85275009__A549__trt_cp | BRD-K85275009__A549__trt_cp | -4.711900 |\n",
"| BRD-K05402890__HA1E__trt_cp | BRD-K05402890__HA1E__trt_cp | -2.309873 |\n",
"| BRD-A58924247__HT29__trt_cp | BRD-A58924247__HT29__trt_cp | -2.229404 |\n",
"| BRD-K91691979__PC3__trt_cp | BRD-K91691979__PC3__trt_cp | -2.309459 |\n",
"| BRD-K19735876__A375__trt_cp | BRD-K19735876__A375__trt_cp | -2.083350 |\n",
"| BRD-A21406558__MCF7__trt_cp | BRD-A21406558__MCF7__trt_cp | -2.156250 |\n",
"| BRD-K07259155__MCF7__trt_cp | BRD-K07259155__MCF7__trt_cp | -2.299050 |\n",
"| ⋮ | ⋮ | ⋮ |\n",
"| SR-12813__NEU__trt_cp | SR-12813__NEU__trt_cp | -2.061450 |\n",
"| LBH-589__NEU__trt_cp | LBH-589__NEU__trt_cp | -2.051542 |\n",
"| BG-1003__NPC__trt_cp | BG-1003__NPC__trt_cp | -2.050464 |\n",
"| LBH-589__NPC__trt_cp | LBH-589__NPC__trt_cp | -2.351810 |\n",
"| BG-1008__NEU__trt_cp | BG-1008__NEU__trt_cp | -2.506527 |\n",
"| temozolomide__NEU__trt_cp | temozolomide__NEU__trt_cp | -2.358148 |\n",
"| BG-1005__NEU__trt_cp | BG-1005__NEU__trt_cp | -2.408175 |\n",
"| BG-1025__NEU__trt_cp | BG-1025__NEU__trt_cp | -2.330200 |\n",
"| C2-dihydroceramide__NEU__trt_cp | C2-dihydroceramide__NEU__trt_cp | -2.060200 |\n",
"| BG-1030__NEU__trt_cp | BG-1030__NEU__trt_cp | -2.047566 |\n",
"| oxamflatin__NPC__trt_cp | oxamflatin__NPC__trt_cp | -2.670142 |\n",
"| BG-1029__NPC__trt_cp | BG-1029__NPC__trt_cp | -2.168213 |\n",
"| BG-1006__NPC__trt_cp | BG-1006__NPC__trt_cp | -2.664152 |\n",
"| BML-284__NPC__trt_cp | BML-284__NPC__trt_cp | -4.036828 |\n",
"| M-344__NPC__trt_cp | M-344__NPC__trt_cp | -2.041860 |\n",
"| BG-1025__NPC__trt_cp | BG-1025__NPC__trt_cp | -2.107575 |\n",
"| BG-1026__NPC__trt_cp | BG-1026__NPC__trt_cp | -2.440128 |\n",
"| NCH-51__NPC__trt_cp | NCH-51__NPC__trt_cp | -2.122013 |\n",
"| BG-1007__NPC__trt_cp | BG-1007__NPC__trt_cp | -2.229874 |\n",
"| BG-1028__NPC__trt_cp | BG-1028__NPC__trt_cp | -2.391268 |\n",
"| BG-1027__NPC__trt_cp | BG-1027__NPC__trt_cp | -2.334610 |\n",
"| tert-butylhydroquinone__MCF7__trt_cp | tert-butylhydroquinone__MCF7__trt_cp | -3.080953 |\n",
"| panobinostat__A375__trt_cp | panobinostat__A375__trt_cp | -2.063759 |\n",
"| staurosporine__A375__trt_cp | staurosporine__A375__trt_cp | -3.507200 |\n",
"| apicidin__A375__trt_cp | apicidin__A375__trt_cp | -2.681550 |\n",
"| BRD-K57064803__MCF7__trt_cp | BRD-K57064803__MCF7__trt_cp | -2.356925 |\n",
"| alpha-tocopherol__MCF7__trt_cp | alpha-tocopherol__MCF7__trt_cp | -2.502400 |\n",
"| JMW-MITF1__MCF7__trt_cp | JMW-MITF1__MCF7__trt_cp | -2.199600 |\n",
"| alpha-tocopherol__PC3__trt_cp | alpha-tocopherol__PC3__trt_cp | -2.310900 |\n",
"| bortezomib__PC3__trt_cp | bortezomib__PC3__trt_cp | -3.855000 |\n",
"\n",
"\n",
"$HOXC5\n",
": \n",
"A data.frame: 49 × 2\n",
"\n",
"| <!--/--> | drug <chr> | zscore <dbl> |\n",
"|---|---|---|\n",
"| aminomethyltransferase__HA1E__trt_cp | aminomethyltransferase__HA1E__trt_cp | -2.349426 |\n",
"| ARP-101__HA1E__trt_cp | ARP-101__HA1E__trt_cp | -2.420850 |\n",
"| homoharringtonine__HA1E__trt_cp | homoharringtonine__HA1E__trt_cp | -2.545411 |\n",
"| CFM-1571__HCC515__trt_cp | CFM-1571__HCC515__trt_cp | -2.027797 |\n",
"| apoptosis-activator-II__HCC515__trt_cp | apoptosis-activator-II__HCC515__trt_cp | -2.027338 |\n",
"| puromycin__VCAP__trt_cp | puromycin__VCAP__trt_cp | -3.208967 |\n",
"| NSC-632839__VCAP__trt_cp | NSC-632839__VCAP__trt_cp | -2.437900 |\n",
"| NNC-711__VCAP__trt_cp | NNC-711__VCAP__trt_cp | -2.587158 |\n",
"| MG-132__VCAP__trt_cp | MG-132__VCAP__trt_cp | -2.497801 |\n",
"| Ro-15-4513__VCAP__trt_cp | Ro-15-4513__VCAP__trt_cp | -2.462467 |\n",
"| R-59022__HA1E__trt_cp | R-59022__HA1E__trt_cp | -2.440392 |\n",
"| cucurbitacin-i__MCF7__trt_cp | cucurbitacin-i__MCF7__trt_cp | -2.504937 |\n",
"| SCH-79797__MCF7__trt_cp | SCH-79797__MCF7__trt_cp | -3.103155 |\n",
"| BRD-K19290969__A549__trt_cp | BRD-K19290969__A549__trt_cp | -2.442208 |\n",
"| BIX-02188__VCAP__trt_cp | BIX-02188__VCAP__trt_cp | -2.021193 |\n",
"| BRD-A98444709__A549__trt_cp | BRD-A98444709__A549__trt_cp | -2.181950 |\n",
"| BRD-K18726304__MCF7__trt_cp | BRD-K18726304__MCF7__trt_cp | -2.498750 |\n",
"| toremifene__MCF7__trt_cp | toremifene__MCF7__trt_cp | -2.111762 |\n",
"| BRD-K32896438__MCF7__trt_cp | BRD-K32896438__MCF7__trt_cp | -2.568452 |\n",
"| RAN-27__NEU__trt_cp | RAN-27__NEU__trt_cp | -2.057970 |\n",
"| BRD-K44893543__NEU__trt_cp | BRD-K44893543__NEU__trt_cp | -2.403568 |\n",
"| cytochalasin-d__MCF7__trt_cp | cytochalasin-d__MCF7__trt_cp | -2.524929 |\n",
"| ST-4029010__NEU__trt_cp | ST-4029010__NEU__trt_cp | -2.160550 |\n",
"| sorafenib__VCAP__trt_cp | sorafenib__VCAP__trt_cp | -2.387828 |\n",
"| BG-FA-0953__VCAP__trt_cp | BG-FA-0953__VCAP__trt_cp | -2.010978 |\n",
"| WYE-354__ASC__trt_cp | WYE-354__ASC__trt_cp | -2.030976 |\n",
"| WYE-125132__MCF7__trt_cp | WYE-125132__MCF7__trt_cp | -2.019033 |\n",
"| verrucarin-a__NEU__trt_cp | verrucarin-a__NEU__trt_cp | -2.535550 |\n",
"| mirin__VCAP__trt_cp | mirin__VCAP__trt_cp | -2.051119 |\n",
"| CGP-71683__MCF7__trt_cp | CGP-71683__MCF7__trt_cp | -2.191356 |\n",
"| NSC-663284__PHH__trt_cp | NSC-663284__PHH__trt_cp | -2.232050 |\n",
"| proadifen__ASC__trt_cp | proadifen__ASC__trt_cp | -2.171099 |\n",
"| anisomycin__NEU__trt_cp | anisomycin__NEU__trt_cp | -2.530992 |\n",
"| formoterol__SKB__trt_cp | formoterol__SKB__trt_cp | -2.052984 |\n",
"| FCCP__MCF7__trt_cp | FCCP__MCF7__trt_cp | -2.068842 |\n",
"| diphenyleneiodonium__MCF7__trt_cp | diphenyleneiodonium__MCF7__trt_cp | -2.738179 |\n",
"| NSC-94258__MCF7__trt_cp | NSC-94258__MCF7__trt_cp | -2.348442 |\n",
"| SQ-22536__NPC__trt_cp | SQ-22536__NPC__trt_cp | -2.024650 |\n",
"| pyrvinium__MCF7__trt_cp | pyrvinium__MCF7__trt_cp | -2.287450 |\n",
"| BRD-K00835201__NEU__trt_cp | BRD-K00835201__NEU__trt_cp | -2.013800 |\n",
"| BRD-K75264577__NEU__trt_cp | BRD-K75264577__NEU__trt_cp | -2.051050 |\n",
"| BRD-K01477275__NPC__trt_cp | BRD-K01477275__NPC__trt_cp | -2.038408 |\n",
"| BRD-K02519835__VCAP__trt_cp | BRD-K02519835__VCAP__trt_cp | -2.148807 |\n",
"| motesanib__HS578T__trt_cp | motesanib__HS578T__trt_cp | -2.047123 |\n",
"| SYK-inhibitor__SKBR3__trt_cp | SYK-inhibitor__SKBR3__trt_cp | -2.655849 |\n",
"| ENMD-2076__A375__trt_cp | ENMD-2076__A375__trt_cp | -2.061680 |\n",
"| BRD-K99636700__HCC515__trt_cp | BRD-K99636700__HCC515__trt_cp | -2.166222 |\n",
"| apicidin__HEPG2__trt_cp | apicidin__HEPG2__trt_cp | -2.335700 |\n",
"| avrainvillamide-analog-4__MCF7__trt_cp | avrainvillamide-analog-4__MCF7__trt_cp | -2.152519 |\n",
"\n",
"\n",
"\n",
"\n"
],
"text/plain": [
"$VENTX\n",
" drug\n",
"butoconazole__HCC515__trt_cp butoconazole__HCC515__trt_cp\n",
"amcinonide__VCAP__trt_cp amcinonide__VCAP__trt_cp\n",
"verteporfin__VCAP__trt_cp verteporfin__VCAP__trt_cp\n",
"napelline__HT29__trt_cp napelline__HT29__trt_cp\n",
"clioquinol__HT29__trt_cp clioquinol__HT29__trt_cp\n",
"NS-3694__VCAP__trt_cp NS-3694__VCAP__trt_cp\n",
"AS-605240__VCAP__trt_cp AS-605240__VCAP__trt_cp\n",
"SJ-172550__VCAP__trt_cp SJ-172550__VCAP__trt_cp\n",
"JAS07-005__VCAP__trt_cp JAS07-005__VCAP__trt_cp\n",
"BRD-A38425832__MCF7__trt_cp BRD-A38425832__MCF7__trt_cp\n",
"BRD-K32827536__PC3__trt_cp BRD-K32827536__PC3__trt_cp\n",
"BRD-K48844671__PC3__trt_cp BRD-K48844671__PC3__trt_cp\n",
"BRD-K23165181__VCAP__trt_cp BRD-K23165181__VCAP__trt_cp\n",
"BRD-K58247702__VCAP__trt_cp BRD-K58247702__VCAP__trt_cp\n",
"BRD-K70917163__VCAP__trt_cp BRD-K70917163__VCAP__trt_cp\n",
"KU-C104140__A549__trt_cp KU-C104140__A549__trt_cp\n",
"BRD-A11095214__MCF7__trt_cp BRD-A11095214__MCF7__trt_cp\n",
"BRD-K33182644__MCF7__trt_cp BRD-K33182644__MCF7__trt_cp\n",
"BRD-K98991361__A549__trt_cp BRD-K98991361__A549__trt_cp\n",
"oxcarbazepine__MCF7__trt_cp oxcarbazepine__MCF7__trt_cp\n",
"lansoprazole__VCAP__trt_cp lansoprazole__VCAP__trt_cp\n",
"kitasamycin__VCAP__trt_cp kitasamycin__VCAP__trt_cp\n",
"BRD-A16581344__A549__trt_cp BRD-A16581344__A549__trt_cp\n",
"BRD-K88556033__A549__trt_cp BRD-K88556033__A549__trt_cp\n",
"RAN-27__NEU__trt_cp RAN-27__NEU__trt_cp\n",
"BRD-K44893543__NEU__trt_cp BRD-K44893543__NEU__trt_cp\n",
"BRD-K58279162__NEU__trt_cp BRD-K58279162__NEU__trt_cp\n",
"BRD-K14316227__NPC__trt_cp BRD-K14316227__NPC__trt_cp\n",
"treprostinil__PHH__trt_cp treprostinil__PHH__trt_cp\n",
"BRD-K82971429__PHH__trt_cp BRD-K82971429__PHH__trt_cp\n",
"BRD-K21672423__SKB__trt_cp BRD-K21672423__SKB__trt_cp\n",
"BRD-K35568648__SKB__trt_cp BRD-K35568648__SKB__trt_cp\n",
"BRD-K98731749__VCAP__trt_cp BRD-K98731749__VCAP__trt_cp\n",
"BRD-K54159704__NEU__trt_cp BRD-K54159704__NEU__trt_cp\n",
"BRD-A60386802__NPC__trt_cp BRD-A60386802__NPC__trt_cp\n",
"BRD-K09460252__SKB__trt_cp BRD-K09460252__SKB__trt_cp\n",
"BRD-A30083233__VCAP__trt_cp BRD-A30083233__VCAP__trt_cp\n",
"BRD-A68274214__VCAP__trt_cp BRD-A68274214__VCAP__trt_cp\n",
"BRD-K16180117__VCAP__trt_cp BRD-K16180117__VCAP__trt_cp\n",
"parthenolide-(alternate-stereo)__VCAP__trt_cp parthenolide-(alternate-stereo)__VCAP__trt_cp\n",
"BRD-K47764688__VCAP__trt_cp BRD-K47764688__VCAP__trt_cp\n",
"BRD-K52914903__VCAP__trt_cp BRD-K52914903__VCAP__trt_cp\n",
"SEW-05685__VCAP__trt_cp SEW-05685__VCAP__trt_cp\n",
"BRD-K88542532__VCAP__trt_cp BRD-K88542532__VCAP__trt_cp\n",
"BRD-A77577770__A549__trt_cp BRD-A77577770__A549__trt_cp\n",
"EMF-BCA1-57__ASC__trt_cp EMF-BCA1-57__ASC__trt_cp\n",
"acitretin__NEU__trt_cp acitretin__NEU__trt_cp\n",
"mitotane__A549__trt_cp mitotane__A549__trt_cp\n",
"aminopentamide__A549__trt_cp aminopentamide__A549__trt_cp\n",
"probenecid__A549__trt_cp probenecid__A549__trt_cp\n",
"NSC-663284__PHH__trt_cp NSC-663284__PHH__trt_cp\n",
"zoxazolamine__PHH__trt_cp zoxazolamine__PHH__trt_cp\n",
"nateglinide__PHH__trt_cp nateglinide__PHH__trt_cp\n",
"LFM-A13__NEU__trt_cp LFM-A13__NEU__trt_cp\n",
"BML-257__NEU__trt_cp BML-257__NEU__trt_cp\n",
"lamotrigine__NEU__trt_cp lamotrigine__NEU__trt_cp\n",
"IC-261__PHH__trt_cp IC-261__PHH__trt_cp\n",
"L-701252__PHH__trt_cp L-701252__PHH__trt_cp\n",
"mometasone__PHH__trt_cp mometasone__PHH__trt_cp\n",
"scoulerine__PHH__trt_cp scoulerine__PHH__trt_cp\n",
"dihydroergotamine__PHH__trt_cp dihydroergotamine__PHH__trt_cp\n",
"dipyridamole__PHH__trt_cp dipyridamole__PHH__trt_cp\n",
"tyrphostin-AG-825__MCF7__trt_cp tyrphostin-AG-825__MCF7__trt_cp\n",
"rosmarinic-acid__NPC__trt_cp rosmarinic-acid__NPC__trt_cp\n",
"amthamine__PHH__trt_cp amthamine__PHH__trt_cp\n",
"NAN-190__PHH__trt_cp NAN-190__PHH__trt_cp\n",
"BRD-K24053449__MCF7__trt_cp BRD-K24053449__MCF7__trt_cp\n",
"BRD-K88278225__PC3__trt_cp BRD-K88278225__PC3__trt_cp\n",
"BRD-K03358980__VCAP__trt_cp BRD-K03358980__VCAP__trt_cp\n",
"BRD-K06592610__VCAP__trt_cp BRD-K06592610__VCAP__trt_cp\n",
"RDR-01440SC__VCAP__trt_cp RDR-01440SC__VCAP__trt_cp\n",
"BRD-K76691125__VCAP__trt_cp BRD-K76691125__VCAP__trt_cp\n",
"tubacin__VCAP__trt_cp tubacin__VCAP__trt_cp\n",
"BRD-K47512679__NPC__trt_cp BRD-K47512679__NPC__trt_cp\n",
"BRD-K05353139__HT29__trt_cp BRD-K05353139__HT29__trt_cp\n",
"BRD-K48598367__NEU__trt_cp BRD-K48598367__NEU__trt_cp\n",
"SA-419083__NPC__trt_cp SA-419083__NPC__trt_cp\n",
"BRD-K28772322__VCAP__trt_cp BRD-K28772322__VCAP__trt_cp\n",
"nocodazole__FIBRNPC__trt_cp nocodazole__FIBRNPC__trt_cp\n",
"AVA__HA1E__trt_cp AVA__HA1E__trt_cp\n",
" zscore\n",
"butoconazole__HCC515__trt_cp -2.043097\n",
"amcinonide__VCAP__trt_cp -2.013700\n",
"verteporfin__VCAP__trt_cp -2.372383\n",
"napelline__HT29__trt_cp -2.024536\n",
"clioquinol__HT29__trt_cp -2.086267\n",
"NS-3694__VCAP__trt_cp -2.178900\n",
"AS-605240__VCAP__trt_cp -2.451528\n",
"SJ-172550__VCAP__trt_cp -2.893954\n",
"JAS07-005__VCAP__trt_cp -2.086582\n",
"BRD-A38425832__MCF7__trt_cp -2.438600\n",
"BRD-K32827536__PC3__trt_cp -2.027371\n",
"BRD-K48844671__PC3__trt_cp -2.115793\n",
"BRD-K23165181__VCAP__trt_cp -2.151439\n",
"BRD-K58247702__VCAP__trt_cp -2.014121\n",
"BRD-K70917163__VCAP__trt_cp -2.195663\n",
"KU-C104140__A549__trt_cp -2.076100\n",
"BRD-A11095214__MCF7__trt_cp -2.200500\n",
"BRD-K33182644__MCF7__trt_cp -2.137250\n",
"BRD-K98991361__A549__trt_cp -2.161300\n",
"oxcarbazepine__MCF7__trt_cp -2.080350\n",
"lansoprazole__VCAP__trt_cp -2.672177\n",
"kitasamycin__VCAP__trt_cp -2.771939\n",
"BRD-A16581344__A549__trt_cp -2.207200\n",
"BRD-K88556033__A549__trt_cp -2.038800\n",
"RAN-27__NEU__trt_cp -2.076294\n",
"BRD-K44893543__NEU__trt_cp -2.608974\n",
"BRD-K58279162__NEU__trt_cp -2.688838\n",
"BRD-K14316227__NPC__trt_cp -2.204158\n",
"treprostinil__PHH__trt_cp -2.756694\n",
"BRD-K82971429__PHH__trt_cp -2.028831\n",
"BRD-K21672423__SKB__trt_cp -2.009029\n",
"BRD-K35568648__SKB__trt_cp -2.132345\n",
"BRD-K98731749__VCAP__trt_cp -2.255098\n",
"BRD-K54159704__NEU__trt_cp -2.431950\n",
"BRD-A60386802__NPC__trt_cp -2.105715\n",
"BRD-K09460252__SKB__trt_cp -2.230373\n",
"BRD-A30083233__VCAP__trt_cp -3.686601\n",
"BRD-A68274214__VCAP__trt_cp -2.685372\n",
"BRD-K16180117__VCAP__trt_cp -3.084749\n",
"parthenolide-(alternate-stereo)__VCAP__trt_cp -2.591435\n",
"BRD-K47764688__VCAP__trt_cp -2.465660\n",
"BRD-K52914903__VCAP__trt_cp -2.128565\n",
"SEW-05685__VCAP__trt_cp -2.412868\n",
"BRD-K88542532__VCAP__trt_cp -2.193973\n",
"BRD-A77577770__A549__trt_cp -2.333757\n",
"EMF-BCA1-57__ASC__trt_cp -2.248311\n",
"acitretin__NEU__trt_cp -2.018050\n",
"mitotane__A549__trt_cp -2.225927\n",
"aminopentamide__A549__trt_cp -2.421756\n",
"probenecid__A549__trt_cp -2.769047\n",
"NSC-663284__PHH__trt_cp -2.211250\n",
"zoxazolamine__PHH__trt_cp -2.148100\n",
"nateglinide__PHH__trt_cp -2.026000\n",
"LFM-A13__NEU__trt_cp -2.864500\n",
"BML-257__NEU__trt_cp -3.350300\n",
"lamotrigine__NEU__trt_cp -2.059334\n",
"IC-261__PHH__trt_cp -2.089171\n",
"L-701252__PHH__trt_cp -3.265500\n",
"mometasone__PHH__trt_cp -2.173689\n",
"scoulerine__PHH__trt_cp -2.078122\n",
"dihydroergotamine__PHH__trt_cp -2.580976\n",
"dipyridamole__PHH__trt_cp -2.045686\n",
"tyrphostin-AG-825__MCF7__trt_cp -2.394913\n",
"rosmarinic-acid__NPC__trt_cp -2.170692\n",
"amthamine__PHH__trt_cp -2.258550\n",
"NAN-190__PHH__trt_cp -4.584300\n",
"BRD-K24053449__MCF7__trt_cp -2.124968\n",
"BRD-K88278225__PC3__trt_cp -5.143122\n",
"BRD-K03358980__VCAP__trt_cp -2.230576\n",
"BRD-K06592610__VCAP__trt_cp -2.063635\n",
"RDR-01440SC__VCAP__trt_cp -2.042054\n",
"BRD-K76691125__VCAP__trt_cp -2.113669\n",
"tubacin__VCAP__trt_cp -3.499640\n",
"BRD-K47512679__NPC__trt_cp -2.032956\n",
"BRD-K05353139__HT29__trt_cp -2.013206\n",
"BRD-K48598367__NEU__trt_cp -2.556500\n",
"SA-419083__NPC__trt_cp -2.028479\n",
"BRD-K28772322__VCAP__trt_cp -2.263741\n",
"nocodazole__FIBRNPC__trt_cp -2.172350\n",
"AVA__HA1E__trt_cp -2.028199\n",
"\n",
"$ISL1\n",
" drug\n",
"BRD-K26684619__CD34__trt_cp BRD-K26684619__CD34__trt_cp\n",
"BRD-A51929314__HA1E__trt_cp BRD-A51929314__HA1E__trt_cp\n",
"MRS-1845__HCC515__trt_cp MRS-1845__HCC515__trt_cp\n",
"melperone__HCC515__trt_cp melperone__HCC515__trt_cp\n",
"FCCP__HCC515__trt_cp FCCP__HCC515__trt_cp\n",
"BCL2-inhibitor__VCAP__trt_cp BCL2-inhibitor__VCAP__trt_cp\n",
"ubenimex__VCAP__trt_cp ubenimex__VCAP__trt_cp\n",
"epitestosterone__VCAP__trt_cp epitestosterone__VCAP__trt_cp\n",
"procainamide__VCAP__trt_cp procainamide__VCAP__trt_cp\n",
"anagrelide__HA1E__trt_cp anagrelide__HA1E__trt_cp\n",
"bithionol__HCC515__trt_cp bithionol__HCC515__trt_cp\n",
"GW-1929__VCAP__trt_cp GW-1929__VCAP__trt_cp\n",
"CMPD-1__A375__trt_cp CMPD-1__A375__trt_cp\n",
"ST-638__HA1E__trt_cp ST-638__HA1E__trt_cp\n",
"fluocinolone-acetonide__HT29__trt_cp fluocinolone-acetonide__HT29__trt_cp\n",
"mitoxantrone__HT29__trt_cp mitoxantrone__HT29__trt_cp\n",
"L-168049__VCAP__trt_cp L-168049__VCAP__trt_cp\n",
"BX-795__HT29__trt_cp BX-795__HT29__trt_cp\n",
"cucurbitacin-i__MCF7__trt_cp cucurbitacin-i__MCF7__trt_cp\n",
"CT-200783__VCAP__trt_cp CT-200783__VCAP__trt_cp\n",
"BRD-K60870698__A375__trt_cp BRD-K60870698__A375__trt_cp\n",
"BRD-K84203638__A375__trt_cp BRD-K84203638__A375__trt_cp\n",
"BRD-K05153001__A549__trt_cp BRD-K05153001__A549__trt_cp\n",
"BRD-K85275009__A549__trt_cp BRD-K85275009__A549__trt_cp\n",
"BRD-K05402890__HA1E__trt_cp BRD-K05402890__HA1E__trt_cp\n",
"BRD-A58924247__HT29__trt_cp BRD-A58924247__HT29__trt_cp\n",
"BRD-K91691979__PC3__trt_cp BRD-K91691979__PC3__trt_cp\n",
"BRD-K19735876__A375__trt_cp BRD-K19735876__A375__trt_cp\n",
"BRD-A21406558__MCF7__trt_cp BRD-A21406558__MCF7__trt_cp\n",
"BRD-K07259155__MCF7__trt_cp BRD-K07259155__MCF7__trt_cp\n",
"BRD-K66884694__MCF7__trt_cp BRD-K66884694__MCF7__trt_cp\n",
"BRD-K44366801__VCAP__trt_cp BRD-K44366801__VCAP__trt_cp\n",
"BRD-K66884694__VCAP__trt_cp BRD-K66884694__VCAP__trt_cp\n",
"BRD-K97936712__VCAP__trt_cp BRD-K97936712__VCAP__trt_cp\n",
"BRD-K43267173__A549__trt_cp BRD-K43267173__A549__trt_cp\n",
"BRD-K36354764__MCF7__trt_cp BRD-K36354764__MCF7__trt_cp\n",
"BRD-K69516039__MCF7__trt_cp BRD-K69516039__MCF7__trt_cp\n",
"BRD-K89224880__VCAP__trt_cp BRD-K89224880__VCAP__trt_cp\n",
"BRD-K31600199__A549__trt_cp BRD-K31600199__A549__trt_cp\n",
"BRD-K96213252__PC3__trt_cp BRD-K96213252__PC3__trt_cp\n",
"BRD-K01265221__VCAP__trt_cp BRD-K01265221__VCAP__trt_cp\n",
"BRD-K49403449__VCAP__trt_cp BRD-K49403449__VCAP__trt_cp\n",
"doxylamine__MCF7__trt_cp doxylamine__MCF7__trt_cp\n",
"BRD-K02223034__A549__trt_cp BRD-K02223034__A549__trt_cp\n",
"BRD-K25731886__A549__trt_cp BRD-K25731886__A549__trt_cp\n",
"alvocidib__A549__trt_cp alvocidib__A549__trt_cp\n",
"BRD-K04534322__NEU__trt_cp BRD-K04534322__NEU__trt_cp\n",
"doxercalciferol__NEU__trt_cp doxercalciferol__NEU__trt_cp\n",
"BRD-K25731886__NEU__trt_cp BRD-K25731886__NEU__trt_cp\n",
"fludarabine__NEU__trt_cp fludarabine__NEU__trt_cp\n",
"vorinostat__NEU__trt_cp vorinostat__NEU__trt_cp\n",
"BRD-K98731749__NEU__trt_cp BRD-K98731749__NEU__trt_cp\n",
"HU-211__NPC__trt_cp HU-211__NPC__trt_cp\n",
"panobinostat__NPC__trt_cp panobinostat__NPC__trt_cp\n",
"MD-II-038__NPC__trt_cp MD-II-038__NPC__trt_cp\n",
"vorinostat__NPC__trt_cp vorinostat__NPC__trt_cp\n",
"BRD-K36767861__PHH__trt_cp BRD-K36767861__PHH__trt_cp\n",
"BRD-K76926998__PHH__trt_cp BRD-K76926998__PHH__trt_cp\n",
"BRD-K02223034__SKB__trt_cp BRD-K02223034__SKB__trt_cp\n",
"SA-1447005__VCAP__trt_cp SA-1447005__VCAP__trt_cp\n",
"KM-01366__A549__trt_cp KM-01366__A549__trt_cp\n",
"cilomilast__A549__trt_cp cilomilast__A549__trt_cp\n",
"STOCK1S-03920__MCF7__trt_cp STOCK1S-03920__MCF7__trt_cp\n",
"BRD-A68274214__NEU__trt_cp BRD-A68274214__NEU__trt_cp\n",
"F-1061-0166__NEU__trt_cp F-1061-0166__NEU__trt_cp\n",
"danusertib__NEU__trt_cp danusertib__NEU__trt_cp\n",
"daunorubicin__NEU__trt_cp daunorubicin__NEU__trt_cp\n",
"BRD-K03176945__NPC__trt_cp BRD-K03176945__NPC__trt_cp\n",
"daunorubicin__NPC__trt_cp daunorubicin__NPC__trt_cp\n",
"YM-155__NPC__trt_cp YM-155__NPC__trt_cp\n",
"BRD-K18163752__VCAP__trt_cp BRD-K18163752__VCAP__trt_cp\n",
"parthenolide-(alternate-stereo)__VCAP__trt_cp parthenolide-(alternate-stereo)__VCAP__trt_cp\n",
"fenretinide__A549__trt_cp fenretinide__A549__trt_cp\n",
"EI-231__NEU__trt_cp EI-231__NEU__trt_cp\n",
"STK-397047__NEU__trt_cp STK-397047__NEU__trt_cp\n",
"HO-013__NEU__trt_cp HO-013__NEU__trt_cp\n",
"SB-590885__NPC__trt_cp SB-590885__NPC__trt_cp\n",
"A-443644__NPC__trt_cp A-443644__NPC__trt_cp\n",
"crizotinib__NPC__trt_cp crizotinib__NPC__trt_cp\n",
"SB-239063__NPC__trt_cp SB-239063__NPC__trt_cp\n",
"fenretinide__NPC__trt_cp fenretinide__NPC__trt_cp\n",
"WZ-3105__NPC__trt_cp WZ-3105__NPC__trt_cp\n",
"torin-2__PHH__trt_cp torin-2__PHH__trt_cp\n",
"linifanib__PHH__trt_cp linifanib__PHH__trt_cp\n",
"BRD-K07061353__VCAP__trt_cp BRD-K07061353__VCAP__trt_cp\n",
"mitotane__A549__trt_cp mitotane__A549__trt_cp\n",
"nocodazole__NPC__trt_cp nocodazole__NPC__trt_cp\n",
"penfluridol__NPC__trt_cp penfluridol__NPC__trt_cp\n",
"podophyllotoxin__NPC__trt_cp podophyllotoxin__NPC__trt_cp\n",
"butoconazole__PHH__trt_cp butoconazole__PHH__trt_cp\n",
"vinblastine__PHH__trt_cp vinblastine__PHH__trt_cp\n",
"paroxetine__PHH__trt_cp paroxetine__PHH__trt_cp\n",
"dicyclohexylurea__SKB__trt_cp dicyclohexylurea__SKB__trt_cp\n",
"anisomycin__ASC__trt_cp anisomycin__ASC__trt_cp\n",
"LFM-A13__NEU__trt_cp LFM-A13__NEU__trt_cp\n",
"bisindolylmaleimide-ix__NEU__trt_cp bisindolylmaleimide-ix__NEU__trt_cp\n",
"BML-257__NEU__trt_cp BML-257__NEU__trt_cp\n",
"caffeic-acid__NEU__trt_cp caffeic-acid__NEU__trt_cp\n",
"BRD-K93541117__NEU__trt_cp BRD-K93541117__NEU__trt_cp\n",
"teniposide__NPC__trt_cp teniposide__NPC__trt_cp\n",
"aminopurvalanol-a__NPC__trt_cp aminopurvalanol-a__NPC__trt_cp\n",
"dextromethorphan__NPC__trt_cp dextromethorphan__NPC__trt_cp\n",
"LY-2183240__NPC__trt_cp LY-2183240__NPC__trt_cp\n",
"methyl-2,5-dihydroxycinnamate__NPC__trt_cp methyl-2,5-dihydroxycinnamate__NPC__trt_cp\n",
"mocimycin__A549__trt_cp mocimycin__A549__trt_cp\n",
"calycanthine__A549__trt_cp calycanthine__A549__trt_cp\n",
"L-701252__ASC__trt_cp L-701252__ASC__trt_cp\n",
"BMY-14802__NPC__trt_cp BMY-14802__NPC__trt_cp\n",
"KF-38789__NPC__trt_cp KF-38789__NPC__trt_cp\n",
"ryuvidine__NPC__trt_cp ryuvidine__NPC__trt_cp\n",
"ER-27319__NPC__trt_cp ER-27319__NPC__trt_cp\n",
"SYK-inhibitor__NPC__trt_cp SYK-inhibitor__NPC__trt_cp\n",
"SB-431542__NPC__trt_cp SB-431542__NPC__trt_cp\n",
"BMY-14802__PHH__trt_cp BMY-14802__PHH__trt_cp\n",
"ER-27319__PHH__trt_cp ER-27319__PHH__trt_cp\n",
"milrinone__PHH__trt_cp milrinone__PHH__trt_cp\n",
"CS-110266__ASC__trt_cp CS-110266__ASC__trt_cp\n",
"gitoxigenin__NPC__trt_cp gitoxigenin__NPC__trt_cp\n",
"cymarin__NPC__trt_cp cymarin__NPC__trt_cp\n",
"amiodarone__PHH__trt_cp amiodarone__PHH__trt_cp\n",
"tranilast__PHH__trt_cp tranilast__PHH__trt_cp\n",
"DMeOB__PHH__trt_cp DMeOB__PHH__trt_cp\n",
"DCEBIO__PHH__trt_cp DCEBIO__PHH__trt_cp\n",
"hexamethyleneamiloride__PHH__trt_cp hexamethyleneamiloride__PHH__trt_cp\n",
"EMF-bca1-16__VCAP__trt_cp EMF-bca1-16__VCAP__trt_cp\n",
"LY-2140023__VCAP__trt_cp LY-2140023__VCAP__trt_cp\n",
"aminohippuric-acid__PC3__trt_cp aminohippuric-acid__PC3__trt_cp\n",
"triphenyl-tin__HA1E__trt_cp triphenyl-tin__HA1E__trt_cp\n",
"tributyltin__HA1E__trt_cp tributyltin__HA1E__trt_cp\n",
"BRD-K86671899__A375__trt_cp BRD-K86671899__A375__trt_cp\n",
"BRD-K23985857__HT29__trt_cp BRD-K23985857__HT29__trt_cp\n",
"BRD-K62242359__HT29__trt_cp BRD-K62242359__HT29__trt_cp\n",
"BRD-K90734091__HT29__trt_cp BRD-K90734091__HT29__trt_cp\n",
"BRD-K00381581__NEU__trt_cp BRD-K00381581__NEU__trt_cp\n",
"BRD-K38294617__NEU__trt_cp BRD-K38294617__NEU__trt_cp\n",
"BRD-K48673964__NEU__trt_cp BRD-K48673964__NEU__trt_cp\n",
"BRD-K88822846__NEU__trt_cp BRD-K88822846__NEU__trt_cp\n",
"BRD-K86048057__NPC__trt_cp BRD-K86048057__NPC__trt_cp\n",
"BRD-K29423519__A549__trt_cp BRD-K29423519__A549__trt_cp\n",
"BRD-K73276569__A549__trt_cp BRD-K73276569__A549__trt_cp\n",
"BRD-K15524596__NEU__trt_cp BRD-K15524596__NEU__trt_cp\n",
"BRD-K79532217__NEU__trt_cp BRD-K79532217__NEU__trt_cp\n",
"BRD-K68504618__NPC__trt_cp BRD-K68504618__NPC__trt_cp\n",
"BRD-K80169513__NPC__trt_cp BRD-K80169513__NPC__trt_cp\n",
"BRD-K81408913__NPC__trt_cp BRD-K81408913__NPC__trt_cp\n",
"BRD-K85205404__NPC__trt_cp BRD-K85205404__NPC__trt_cp\n",
"BRD-K36620425__VCAP__trt_cp BRD-K36620425__VCAP__trt_cp\n",
"BRD-K18545493__VCAP__trt_cp BRD-K18545493__VCAP__trt_cp\n",
"BRD-K97255584__VCAP__trt_cp BRD-K97255584__VCAP__trt_cp\n",
"peruvoside__VCAP__trt_cp peruvoside__VCAP__trt_cp\n",
"lanatoside-c__VCAP__trt_cp lanatoside-c__VCAP__trt_cp\n",
"BRD-K34314104__VCAP__trt_cp BRD-K34314104__VCAP__trt_cp\n",
"BRD-K26510616__PC3__trt_cp BRD-K26510616__PC3__trt_cp\n",
"QL-X-138__MCF10A__trt_cp QL-X-138__MCF10A__trt_cp\n",
"PD-0325901__BT20__trt_cp PD-0325901__BT20__trt_cp\n",
"ON-01910__BT20__trt_cp ON-01910__BT20__trt_cp\n",
"SA-1925610__MCF7__trt_cp SA-1925610__MCF7__trt_cp\n",
"SA-3676__NKDBA__trt_cp SA-3676__NKDBA__trt_cp\n",
"SA-1459213__MCF7__trt_cp SA-1459213__MCF7__trt_cp\n",
"BRD-A12426960__FIBRNPC__trt_cp BRD-A12426960__FIBRNPC__trt_cp\n",
"ephedrine__FIBRNPC__trt_cp ephedrine__FIBRNPC__trt_cp\n",
"6-nitrodopamine__FIBRNPC__trt_cp 6-nitrodopamine__FIBRNPC__trt_cp\n",
"BRD-K19653414__FIBRNPC__trt_cp BRD-K19653414__FIBRNPC__trt_cp\n",
"n-bromoacetyltryptamine__FIBRNPC__trt_cp n-bromoacetyltryptamine__FIBRNPC__trt_cp\n",
"BRD-A42610307__NEU__trt_cp BRD-A42610307__NEU__trt_cp\n",
"BRD-A86146706__NEU__trt_cp BRD-A86146706__NEU__trt_cp\n",
"BG-1003__NEU__trt_cp BG-1003__NEU__trt_cp\n",
"SR-12813__NEU__trt_cp SR-12813__NEU__trt_cp\n",
"LBH-589__NEU__trt_cp LBH-589__NEU__trt_cp\n",
"BG-1003__NPC__trt_cp BG-1003__NPC__trt_cp\n",
"LBH-589__NPC__trt_cp LBH-589__NPC__trt_cp\n",
"BG-1008__NEU__trt_cp BG-1008__NEU__trt_cp\n",
"temozolomide__NEU__trt_cp temozolomide__NEU__trt_cp\n",
"BG-1005__NEU__trt_cp BG-1005__NEU__trt_cp\n",
"BG-1025__NEU__trt_cp BG-1025__NEU__trt_cp\n",
"C2-dihydroceramide__NEU__trt_cp C2-dihydroceramide__NEU__trt_cp\n",
"BG-1030__NEU__trt_cp BG-1030__NEU__trt_cp\n",
"oxamflatin__NPC__trt_cp oxamflatin__NPC__trt_cp\n",
"BG-1029__NPC__trt_cp BG-1029__NPC__trt_cp\n",
"BG-1006__NPC__trt_cp BG-1006__NPC__trt_cp\n",
"BML-284__NPC__trt_cp BML-284__NPC__trt_cp\n",
"M-344__NPC__trt_cp M-344__NPC__trt_cp\n",
"BG-1025__NPC__trt_cp BG-1025__NPC__trt_cp\n",
"BG-1026__NPC__trt_cp BG-1026__NPC__trt_cp\n",
"NCH-51__NPC__trt_cp NCH-51__NPC__trt_cp\n",
"BG-1007__NPC__trt_cp BG-1007__NPC__trt_cp\n",
"BG-1028__NPC__trt_cp BG-1028__NPC__trt_cp\n",
"BG-1027__NPC__trt_cp BG-1027__NPC__trt_cp\n",
"tert-butylhydroquinone__MCF7__trt_cp tert-butylhydroquinone__MCF7__trt_cp\n",
"panobinostat__A375__trt_cp panobinostat__A375__trt_cp\n",
"staurosporine__A375__trt_cp staurosporine__A375__trt_cp\n",
"apicidin__A375__trt_cp apicidin__A375__trt_cp\n",
"BRD-K57064803__MCF7__trt_cp BRD-K57064803__MCF7__trt_cp\n",
"alpha-tocopherol__MCF7__trt_cp alpha-tocopherol__MCF7__trt_cp\n",
"JMW-MITF1__MCF7__trt_cp JMW-MITF1__MCF7__trt_cp\n",
"alpha-tocopherol__PC3__trt_cp alpha-tocopherol__PC3__trt_cp\n",
"bortezomib__PC3__trt_cp bortezomib__PC3__trt_cp\n",
" zscore\n",
"BRD-K26684619__CD34__trt_cp -2.040950\n",
"BRD-A51929314__HA1E__trt_cp -2.227154\n",
"MRS-1845__HCC515__trt_cp -2.417191\n",
"melperone__HCC515__trt_cp -2.385237\n",
"FCCP__HCC515__trt_cp -2.176191\n",
"BCL2-inhibitor__VCAP__trt_cp -2.520154\n",
"ubenimex__VCAP__trt_cp -2.167702\n",
"epitestosterone__VCAP__trt_cp -2.142600\n",
"procainamide__VCAP__trt_cp -2.136900\n",
"anagrelide__HA1E__trt_cp -2.888882\n",
"bithionol__HCC515__trt_cp -2.335168\n",
"GW-1929__VCAP__trt_cp -3.890623\n",
"CMPD-1__A375__trt_cp -2.118605\n",
"ST-638__HA1E__trt_cp -2.139165\n",
"fluocinolone-acetonide__HT29__trt_cp -2.311850\n",
"mitoxantrone__HT29__trt_cp -2.173384\n",
"L-168049__VCAP__trt_cp -2.498789\n",
"BX-795__HT29__trt_cp -2.146887\n",
"cucurbitacin-i__MCF7__trt_cp -2.131572\n",
"CT-200783__VCAP__trt_cp -2.346538\n",
"BRD-K60870698__A375__trt_cp -2.611861\n",
"BRD-K84203638__A375__trt_cp -2.241982\n",
"BRD-K05153001__A549__trt_cp -2.140815\n",
"BRD-K85275009__A549__trt_cp -4.711900\n",
"BRD-K05402890__HA1E__trt_cp -2.309873\n",
"BRD-A58924247__HT29__trt_cp -2.229404\n",
"BRD-K91691979__PC3__trt_cp -2.309459\n",
"BRD-K19735876__A375__trt_cp -2.083350\n",
"BRD-A21406558__MCF7__trt_cp -2.156250\n",
"BRD-K07259155__MCF7__trt_cp -2.299050\n",
"BRD-K66884694__MCF7__trt_cp -2.475050\n",
"BRD-K44366801__VCAP__trt_cp -2.178808\n",
"BRD-K66884694__VCAP__trt_cp -2.011937\n",
"BRD-K97936712__VCAP__trt_cp -3.313371\n",
"BRD-K43267173__A549__trt_cp -2.390900\n",
"BRD-K36354764__MCF7__trt_cp -3.101150\n",
"BRD-K69516039__MCF7__trt_cp -2.021250\n",
"BRD-K89224880__VCAP__trt_cp -2.112464\n",
"BRD-K31600199__A549__trt_cp -2.020900\n",
"BRD-K96213252__PC3__trt_cp -2.565480\n",
"BRD-K01265221__VCAP__trt_cp -2.176564\n",
"BRD-K49403449__VCAP__trt_cp -2.060382\n",
"doxylamine__MCF7__trt_cp -2.074550\n",
"BRD-K02223034__A549__trt_cp -2.238800\n",
"BRD-K25731886__A549__trt_cp -4.073600\n",
"alvocidib__A549__trt_cp -3.286200\n",
"BRD-K04534322__NEU__trt_cp -2.297000\n",
"doxercalciferol__NEU__trt_cp -2.532200\n",
"BRD-K25731886__NEU__trt_cp -2.935900\n",
"fludarabine__NEU__trt_cp -2.533750\n",
"vorinostat__NEU__trt_cp -2.218620\n",
"BRD-K98731749__NEU__trt_cp -3.041465\n",
"HU-211__NPC__trt_cp -2.471365\n",
"panobinostat__NPC__trt_cp -2.327604\n",
"MD-II-038__NPC__trt_cp -2.662000\n",
"vorinostat__NPC__trt_cp -3.182482\n",
"BRD-K36767861__PHH__trt_cp -3.222438\n",
"BRD-K76926998__PHH__trt_cp -2.428900\n",
"BRD-K02223034__SKB__trt_cp -2.220776\n",
"SA-1447005__VCAP__trt_cp -2.625348\n",
"KM-01366__A549__trt_cp -2.407488\n",
"cilomilast__A549__trt_cp -2.377500\n",
"STOCK1S-03920__MCF7__trt_cp -2.238906\n",
"BRD-A68274214__NEU__trt_cp -2.049750\n",
"F-1061-0166__NEU__trt_cp -2.821000\n",
"danusertib__NEU__trt_cp -2.525500\n",
"daunorubicin__NEU__trt_cp -3.230900\n",
"BRD-K03176945__NPC__trt_cp -3.337900\n",
"daunorubicin__NPC__trt_cp -2.862800\n",
"YM-155__NPC__trt_cp -2.259500\n",
"BRD-K18163752__VCAP__trt_cp -2.160134\n",
"parthenolide-(alternate-stereo)__VCAP__trt_cp -2.302193\n",
"fenretinide__A549__trt_cp -2.163292\n",
"EI-231__NEU__trt_cp -2.552800\n",
"STK-397047__NEU__trt_cp -2.067650\n",
"HO-013__NEU__trt_cp -2.231300\n",
"SB-590885__NPC__trt_cp -2.488000\n",
"A-443644__NPC__trt_cp -3.773600\n",
"crizotinib__NPC__trt_cp -2.158628\n",
"SB-239063__NPC__trt_cp -2.090600\n",
"fenretinide__NPC__trt_cp -2.259500\n",
"WZ-3105__NPC__trt_cp -2.444200\n",
"torin-2__PHH__trt_cp -2.098830\n",
"linifanib__PHH__trt_cp -2.263827\n",
"BRD-K07061353__VCAP__trt_cp -2.104658\n",
"mitotane__A549__trt_cp -2.035658\n",
"nocodazole__NPC__trt_cp -2.571381\n",
"penfluridol__NPC__trt_cp -4.722900\n",
"podophyllotoxin__NPC__trt_cp -2.724479\n",
"butoconazole__PHH__trt_cp -2.217050\n",
"vinblastine__PHH__trt_cp -2.215100\n",
"paroxetine__PHH__trt_cp -2.036100\n",
"dicyclohexylurea__SKB__trt_cp -2.763450\n",
"anisomycin__ASC__trt_cp -2.111786\n",
"LFM-A13__NEU__trt_cp -4.818600\n",
"bisindolylmaleimide-ix__NEU__trt_cp -2.053642\n",
"BML-257__NEU__trt_cp -5.686600\n",
"caffeic-acid__NEU__trt_cp -2.145504\n",
"BRD-K93541117__NEU__trt_cp -2.055563\n",
"teniposide__NPC__trt_cp -2.629349\n",
"aminopurvalanol-a__NPC__trt_cp -2.470100\n",
"dextromethorphan__NPC__trt_cp -2.140700\n",
"LY-2183240__NPC__trt_cp -2.371386\n",
"methyl-2,5-dihydroxycinnamate__NPC__trt_cp -2.420496\n",
"mocimycin__A549__trt_cp -2.049930\n",
"calycanthine__A549__trt_cp -2.105199\n",
"L-701252__ASC__trt_cp -4.062200\n",
"BMY-14802__NPC__trt_cp -2.252357\n",
"KF-38789__NPC__trt_cp -2.480147\n",
"ryuvidine__NPC__trt_cp -2.028050\n",
"ER-27319__NPC__trt_cp -2.306100\n",
"SYK-inhibitor__NPC__trt_cp -2.415230\n",
"SB-431542__NPC__trt_cp -3.160610\n",
"BMY-14802__PHH__trt_cp -2.118578\n",
"ER-27319__PHH__trt_cp -2.346425\n",
"milrinone__PHH__trt_cp -2.402087\n",
"CS-110266__ASC__trt_cp -3.594700\n",
"gitoxigenin__NPC__trt_cp -2.226500\n",
"cymarin__NPC__trt_cp -2.899550\n",
"amiodarone__PHH__trt_cp -3.548564\n",
"tranilast__PHH__trt_cp -3.020363\n",
"DMeOB__PHH__trt_cp -2.837748\n",
"DCEBIO__PHH__trt_cp -4.610377\n",
"hexamethyleneamiloride__PHH__trt_cp -2.153800\n",
"EMF-bca1-16__VCAP__trt_cp -2.197326\n",
"LY-2140023__VCAP__trt_cp -2.124259\n",
"aminohippuric-acid__PC3__trt_cp -2.049750\n",
"triphenyl-tin__HA1E__trt_cp -2.005953\n",
"tributyltin__HA1E__trt_cp -3.094550\n",
"BRD-K86671899__A375__trt_cp -2.286732\n",
"BRD-K23985857__HT29__trt_cp -2.080577\n",
"BRD-K62242359__HT29__trt_cp -2.488255\n",
"BRD-K90734091__HT29__trt_cp -2.162145\n",
"BRD-K00381581__NEU__trt_cp -2.035250\n",
"BRD-K38294617__NEU__trt_cp -2.160950\n",
"BRD-K48673964__NEU__trt_cp -2.307650\n",
"BRD-K88822846__NEU__trt_cp -2.472500\n",
"BRD-K86048057__NPC__trt_cp -2.548067\n",
"BRD-K29423519__A549__trt_cp -2.396733\n",
"BRD-K73276569__A549__trt_cp -2.140650\n",
"BRD-K15524596__NEU__trt_cp -2.229450\n",
"BRD-K79532217__NEU__trt_cp -2.014550\n",
"BRD-K68504618__NPC__trt_cp -2.003538\n",
"BRD-K80169513__NPC__trt_cp -2.226549\n",
"BRD-K81408913__NPC__trt_cp -2.731183\n",
"BRD-K85205404__NPC__trt_cp -2.147588\n",
"BRD-K36620425__VCAP__trt_cp -2.140300\n",
"BRD-K18545493__VCAP__trt_cp -2.066177\n",
"BRD-K97255584__VCAP__trt_cp -2.006109\n",
"peruvoside__VCAP__trt_cp -2.691100\n",
"lanatoside-c__VCAP__trt_cp -2.178000\n",
"BRD-K34314104__VCAP__trt_cp -3.205300\n",
"BRD-K26510616__PC3__trt_cp -2.360850\n",
"QL-X-138__MCF10A__trt_cp -2.111429\n",
"PD-0325901__BT20__trt_cp -2.014726\n",
"ON-01910__BT20__trt_cp -2.140587\n",
"SA-1925610__MCF7__trt_cp -2.547700\n",
"SA-3676__NKDBA__trt_cp -2.158700\n",
"SA-1459213__MCF7__trt_cp -2.359300\n",
"BRD-A12426960__FIBRNPC__trt_cp -2.284850\n",
"ephedrine__FIBRNPC__trt_cp -2.402400\n",
"6-nitrodopamine__FIBRNPC__trt_cp -2.209700\n",
"BRD-K19653414__FIBRNPC__trt_cp -2.113800\n",
"n-bromoacetyltryptamine__FIBRNPC__trt_cp -2.205550\n",
"BRD-A42610307__NEU__trt_cp -2.110316\n",
"BRD-A86146706__NEU__trt_cp -2.311600\n",
"BG-1003__NEU__trt_cp -2.279669\n",
"SR-12813__NEU__trt_cp -2.061450\n",
"LBH-589__NEU__trt_cp -2.051542\n",
"BG-1003__NPC__trt_cp -2.050464\n",
"LBH-589__NPC__trt_cp -2.351810\n",
"BG-1008__NEU__trt_cp -2.506527\n",
"temozolomide__NEU__trt_cp -2.358148\n",
"BG-1005__NEU__trt_cp -2.408175\n",
"BG-1025__NEU__trt_cp -2.330200\n",
"C2-dihydroceramide__NEU__trt_cp -2.060200\n",
"BG-1030__NEU__trt_cp -2.047566\n",
"oxamflatin__NPC__trt_cp -2.670142\n",
"BG-1029__NPC__trt_cp -2.168213\n",
"BG-1006__NPC__trt_cp -2.664152\n",
"BML-284__NPC__trt_cp -4.036828\n",
"M-344__NPC__trt_cp -2.041860\n",
"BG-1025__NPC__trt_cp -2.107575\n",
"BG-1026__NPC__trt_cp -2.440128\n",
"NCH-51__NPC__trt_cp -2.122013\n",
"BG-1007__NPC__trt_cp -2.229874\n",
"BG-1028__NPC__trt_cp -2.391268\n",
"BG-1027__NPC__trt_cp -2.334610\n",
"tert-butylhydroquinone__MCF7__trt_cp -3.080953\n",
"panobinostat__A375__trt_cp -2.063759\n",
"staurosporine__A375__trt_cp -3.507200\n",
"apicidin__A375__trt_cp -2.681550\n",
"BRD-K57064803__MCF7__trt_cp -2.356925\n",
"alpha-tocopherol__MCF7__trt_cp -2.502400\n",
"JMW-MITF1__MCF7__trt_cp -2.199600\n",
"alpha-tocopherol__PC3__trt_cp -2.310900\n",
"bortezomib__PC3__trt_cp -3.855000\n",
"\n",
"$HOXC5\n",
" drug\n",
"aminomethyltransferase__HA1E__trt_cp aminomethyltransferase__HA1E__trt_cp\n",
"ARP-101__HA1E__trt_cp ARP-101__HA1E__trt_cp\n",
"homoharringtonine__HA1E__trt_cp homoharringtonine__HA1E__trt_cp\n",
"CFM-1571__HCC515__trt_cp CFM-1571__HCC515__trt_cp\n",
"apoptosis-activator-II__HCC515__trt_cp apoptosis-activator-II__HCC515__trt_cp\n",
"puromycin__VCAP__trt_cp puromycin__VCAP__trt_cp\n",
"NSC-632839__VCAP__trt_cp NSC-632839__VCAP__trt_cp\n",
"NNC-711__VCAP__trt_cp NNC-711__VCAP__trt_cp\n",
"MG-132__VCAP__trt_cp MG-132__VCAP__trt_cp\n",
"Ro-15-4513__VCAP__trt_cp Ro-15-4513__VCAP__trt_cp\n",
"R-59022__HA1E__trt_cp R-59022__HA1E__trt_cp\n",
"cucurbitacin-i__MCF7__trt_cp cucurbitacin-i__MCF7__trt_cp\n",
"SCH-79797__MCF7__trt_cp SCH-79797__MCF7__trt_cp\n",
"BRD-K19290969__A549__trt_cp BRD-K19290969__A549__trt_cp\n",
"BIX-02188__VCAP__trt_cp BIX-02188__VCAP__trt_cp\n",
"BRD-A98444709__A549__trt_cp BRD-A98444709__A549__trt_cp\n",
"BRD-K18726304__MCF7__trt_cp BRD-K18726304__MCF7__trt_cp\n",
"toremifene__MCF7__trt_cp toremifene__MCF7__trt_cp\n",
"BRD-K32896438__MCF7__trt_cp BRD-K32896438__MCF7__trt_cp\n",
"RAN-27__NEU__trt_cp RAN-27__NEU__trt_cp\n",
"BRD-K44893543__NEU__trt_cp BRD-K44893543__NEU__trt_cp\n",
"cytochalasin-d__MCF7__trt_cp cytochalasin-d__MCF7__trt_cp\n",
"ST-4029010__NEU__trt_cp ST-4029010__NEU__trt_cp\n",
"sorafenib__VCAP__trt_cp sorafenib__VCAP__trt_cp\n",
"BG-FA-0953__VCAP__trt_cp BG-FA-0953__VCAP__trt_cp\n",
"WYE-354__ASC__trt_cp WYE-354__ASC__trt_cp\n",
"WYE-125132__MCF7__trt_cp WYE-125132__MCF7__trt_cp\n",
"verrucarin-a__NEU__trt_cp verrucarin-a__NEU__trt_cp\n",
"mirin__VCAP__trt_cp mirin__VCAP__trt_cp\n",
"CGP-71683__MCF7__trt_cp CGP-71683__MCF7__trt_cp\n",
"NSC-663284__PHH__trt_cp NSC-663284__PHH__trt_cp\n",
"proadifen__ASC__trt_cp proadifen__ASC__trt_cp\n",
"anisomycin__NEU__trt_cp anisomycin__NEU__trt_cp\n",
"formoterol__SKB__trt_cp formoterol__SKB__trt_cp\n",
"FCCP__MCF7__trt_cp FCCP__MCF7__trt_cp\n",
"diphenyleneiodonium__MCF7__trt_cp diphenyleneiodonium__MCF7__trt_cp\n",
"NSC-94258__MCF7__trt_cp NSC-94258__MCF7__trt_cp\n",
"SQ-22536__NPC__trt_cp SQ-22536__NPC__trt_cp\n",
"pyrvinium__MCF7__trt_cp pyrvinium__MCF7__trt_cp\n",
"BRD-K00835201__NEU__trt_cp BRD-K00835201__NEU__trt_cp\n",
"BRD-K75264577__NEU__trt_cp BRD-K75264577__NEU__trt_cp\n",
"BRD-K01477275__NPC__trt_cp BRD-K01477275__NPC__trt_cp\n",
"BRD-K02519835__VCAP__trt_cp BRD-K02519835__VCAP__trt_cp\n",
"motesanib__HS578T__trt_cp motesanib__HS578T__trt_cp\n",
"SYK-inhibitor__SKBR3__trt_cp SYK-inhibitor__SKBR3__trt_cp\n",
"ENMD-2076__A375__trt_cp ENMD-2076__A375__trt_cp\n",
"BRD-K99636700__HCC515__trt_cp BRD-K99636700__HCC515__trt_cp\n",
"apicidin__HEPG2__trt_cp apicidin__HEPG2__trt_cp\n",
"avrainvillamide-analog-4__MCF7__trt_cp avrainvillamide-analog-4__MCF7__trt_cp\n",
" zscore\n",
"aminomethyltransferase__HA1E__trt_cp -2.349426\n",
"ARP-101__HA1E__trt_cp -2.420850\n",
"homoharringtonine__HA1E__trt_cp -2.545411\n",
"CFM-1571__HCC515__trt_cp -2.027797\n",
"apoptosis-activator-II__HCC515__trt_cp -2.027338\n",
"puromycin__VCAP__trt_cp -3.208967\n",
"NSC-632839__VCAP__trt_cp -2.437900\n",
"NNC-711__VCAP__trt_cp -2.587158\n",
"MG-132__VCAP__trt_cp -2.497801\n",
"Ro-15-4513__VCAP__trt_cp -2.462467\n",
"R-59022__HA1E__trt_cp -2.440392\n",
"cucurbitacin-i__MCF7__trt_cp -2.504937\n",
"SCH-79797__MCF7__trt_cp -3.103155\n",
"BRD-K19290969__A549__trt_cp -2.442208\n",
"BIX-02188__VCAP__trt_cp -2.021193\n",
"BRD-A98444709__A549__trt_cp -2.181950\n",
"BRD-K18726304__MCF7__trt_cp -2.498750\n",
"toremifene__MCF7__trt_cp -2.111762\n",
"BRD-K32896438__MCF7__trt_cp -2.568452\n",
"RAN-27__NEU__trt_cp -2.057970\n",
"BRD-K44893543__NEU__trt_cp -2.403568\n",
"cytochalasin-d__MCF7__trt_cp -2.524929\n",
"ST-4029010__NEU__trt_cp -2.160550\n",
"sorafenib__VCAP__trt_cp -2.387828\n",
"BG-FA-0953__VCAP__trt_cp -2.010978\n",
"WYE-354__ASC__trt_cp -2.030976\n",
"WYE-125132__MCF7__trt_cp -2.019033\n",
"verrucarin-a__NEU__trt_cp -2.535550\n",
"mirin__VCAP__trt_cp -2.051119\n",
"CGP-71683__MCF7__trt_cp -2.191356\n",
"NSC-663284__PHH__trt_cp -2.232050\n",
"proadifen__ASC__trt_cp -2.171099\n",
"anisomycin__NEU__trt_cp -2.530992\n",
"formoterol__SKB__trt_cp -2.052984\n",
"FCCP__MCF7__trt_cp -2.068842\n",
"diphenyleneiodonium__MCF7__trt_cp -2.738179\n",
"NSC-94258__MCF7__trt_cp -2.348442\n",
"SQ-22536__NPC__trt_cp -2.024650\n",
"pyrvinium__MCF7__trt_cp -2.287450\n",
"BRD-K00835201__NEU__trt_cp -2.013800\n",
"BRD-K75264577__NEU__trt_cp -2.051050\n",
"BRD-K01477275__NPC__trt_cp -2.038408\n",
"BRD-K02519835__VCAP__trt_cp -2.148807\n",
"motesanib__HS578T__trt_cp -2.047123\n",
"SYK-inhibitor__SKBR3__trt_cp -2.655849\n",
"ENMD-2076__A375__trt_cp -2.061680\n",
"BRD-K99636700__HCC515__trt_cp -2.166222\n",
"apicidin__HEPG2__trt_cp -2.335700\n",
"avrainvillamide-analog-4__MCF7__trt_cp -2.152519\n"
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"####screen the drug with decreased the TF's expression\n",
"drug.lists <- list()\n",
"for(i in 1:nrow(lincs.TF.matrix)){\n",
" zscore <- lincs.TF.matrix[i,]\n",
" info <- data.frame(drug = colnames(lincs.TF.matrix), zscore = zscore)\n",
" sig.drug <- which(info$zscore < -2) \n",
" if(length(sig.drug)>0){\n",
" sig.info <- info[sig.drug,]\n",
" }else{\n",
" sig.info <- NULL\n",
" }\n",
" drug.lists <- c(drug.lists, list(sig.info))\n",
"}\n",
"names(drug.lists) <- rownames(lincs.TF.matrix)\n",
"drug.lists"
]
},
{
"cell_type": "code",
"execution_count": 7,
"id": "61e3f9ea-c347-4e6e-bb49-0119d7e72528",
"metadata": {
"collapsed": true,
"execution": {
"iopub.execute_input": "2021-09-22T03:01:15.962166Z",
"iopub.status.busy": "2021-09-22T03:01:15.961282Z",
"iopub.status.idle": "2021-09-22T03:01:15.991988Z",
"shell.execute_reply": "2021-09-22T03:01:15.990966Z"
},
"jupyter": {
"outputs_hidden": true,
"source_hidden": true
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/plain": [
"drugs\n",
" BRD-A30083233__VCAP__trt_cp \n",
" 6 \n",
"parthenolide-(alternate-stereo)__VCAP__trt_cp \n",
" 6 \n",
" BML-257__NEU__trt_cp \n",
" 5 \n",
" tubacin__VCAP__trt_cp \n",
" 5 \n",
" 1-phenylbiguanide__PHH__trt_cp \n",
" 4 \n",
" BRD-A68274214__VCAP__trt_cp \n",
" 4 \n",
" BRD-K25731886__A549__trt_cp \n",
" 4 \n",
" genistein__VCAP__trt_cp \n",
" 4 \n",
" homoharringtonine__HA1E__trt_cp \n",
" 4 \n",
" kitasamycin__VCAP__trt_cp \n",
" 4 \n",
" LFM-A13__NEU__trt_cp \n",
" 4 \n",
" NSC-663284__PHH__trt_cp \n",
" 4 \n",
" anisomycin__NEU__trt_cp \n",
" 3 \n",
" BRD-K02519835__VCAP__trt_cp \n",
" 3 \n",
" BRD-K16180117__VCAP__trt_cp \n",
" 3 \n",
" BRD-K39345836__PC3__trt_cp \n",
" 3 \n",
" BRD-K44893543__NEU__trt_cp \n",
" 3 \n",
" BRD-K52914903__VCAP__trt_cp \n",
" 3 \n",
" BRD-K88278225__PC3__trt_cp \n",
" 3 \n",
" CGP-71683__MCF7__trt_cp \n",
" 3 \n",
" cucurbitacin-i__PHH__trt_cp \n",
" 3 \n",
" emetine__HA1E__trt_cp \n",
" 3 \n",
" IC-261__PHH__trt_cp \n",
" 3 \n",
" lansoprazole__VCAP__trt_cp \n",
" 3 \n",
" NAN-190__PHH__trt_cp \n",
" 3 \n",
" PD-173074__PHH__trt_cp \n",
" 3 \n",
" probenecid__A549__trt_cp \n",
" 3 \n",
" SEW-05685__VCAP__trt_cp \n",
" 3 \n",
" SJ-172550__VCAP__trt_cp \n",
" 3 \n",
" treprostinil__PHH__trt_cp \n",
" 3 \n",
" trichostatin-a__HA1E__trt_cp \n",
" 3 \n",
" verrucarin-a__NEU__trt_cp \n",
" 3 \n",
" verteporfin__VCAP__trt_cp \n",
" 3 \n",
" vinblastine__PHH__trt_cp \n",
" 3 \n",
" acitretin__NEU__trt_cp \n",
" 2 \n",
" apicidin__A375__trt_cp \n",
" 2 \n",
" apicidin__HEPG2__trt_cp \n",
" 2 \n",
" AS-605240__VCAP__trt_cp \n",
" 2 \n",
" avrainvillamide-analog-4__MCF7__trt_cp \n",
" 2 \n",
" BCL2-inhibitor__VCAP__trt_cp \n",
" 2 \n",
" BG-1003__NEU__trt_cp \n",
" 2 \n",
" BG-1006__NPC__trt_cp \n",
" 2 \n",
" BMY-14802__PHH__trt_cp \n",
" 2 \n",
" bortezomib__PC3__trt_cp \n",
" 2 \n",
" BRD-A16581344__A549__trt_cp \n",
" 2 \n",
" BRD-A38425832__VCAP__trt_cp \n",
" 2 \n",
" BRD-K03176945__NPC__trt_cp \n",
" 2 \n",
" BRD-K04534322__NEU__trt_cp \n",
" 2 \n",
" BRD-K05153001__A549__trt_cp \n",
" 2 \n",
" BRD-K05402890__HT29__trt_cp \n",
" 2 \n",
" BRD-K16827616__HT29__trt_cp \n",
" 2 \n",
" BRD-K25731886__NEU__trt_cp \n",
" 2 \n",
" BRD-K26684619__CD34__trt_cp \n",
" 2 \n",
" BRD-K34314104__VCAP__trt_cp \n",
" 2 \n",
" BRD-K44494044__NEU__trt_cp \n",
" 2 \n",
" BRD-K47764688__VCAP__trt_cp \n",
" 2 \n",
" BRD-K58247702__VCAP__trt_cp \n",
" 2 \n",
" BRD-K58279162__NEU__trt_cp \n",
" 2 \n",
" BRD-K59556282__NEU__trt_cp \n",
" 2 \n",
" BRD-K67236950__HT29__trt_cp \n",
" 2 \n",
" BRD-K72307842__HA1E__trt_cp \n",
" 2 \n",
" BRD-K75907833__PC3__trt_cp \n",
" 2 \n",
" BRD-K96213252__PC3__trt_cp \n",
" 2 \n",
" BRD-K98731749__NEU__trt_cp \n",
" 2 \n",
" brefeldin-a__HA1E__trt_cp \n",
" 2 \n",
" caffeine__HCC515__trt_cp \n",
" 2 \n",
" cephaeline__ASC__trt_cp \n",
" 2 \n",
" cilomilast__A549__trt_cp \n",
" 2 \n",
" cucurbitacin-i__MCF7__trt_cp \n",
" 2 \n",
" cyclopiazonic-acid__NEU__trt_cp \n",
" 2 \n",
" DMeOB__PHH__trt_cp \n",
" 2 \n",
" EMF-BCA1-57__ASC__trt_cp \n",
" 2 \n",
" GW-405833__HA1E__trt_cp \n",
" 2 \n",
" GW-7647__PHH__trt_cp \n",
" 2 \n",
" GW-7647__SKB__trt_cp \n",
" 2 \n",
" helveticoside__HA1E__trt_cp \n",
" 2 \n",
" HG-5-113-01__BT20__trt_cp \n",
" 2 \n",
" HO-013__NEU__trt_cp \n",
" 2 \n",
" ipsapirone__HT29__trt_cp \n",
" 2 \n",
" JMW-MITF1__MCF7__trt_cp \n",
" 2 \n",
" kinetin-riboside__HA1E__trt_cp \n",
" 2 \n",
" KU-C103853__MCF7__trt_cp \n",
" 2 \n",
" L-701252__PHH__trt_cp \n",
" 2 \n",
" M-344__NEU__trt_cp \n",
" 2 \n",
" mitotane__A549__trt_cp \n",
" 2 \n",
" MW-STK33-2B__A549__trt_cp \n",
" 2 \n",
" panobinostat__A375__trt_cp \n",
" 2 \n",
" panobinostat__HEPG2__trt_cp \n",
" 2 \n",
" panobinostat__NPC__trt_cp \n",
" 2 \n",
" PCI-24781__VCAP__trt_cp \n",
" 2 \n",
" PNU-96415E__HA1E__trt_cp \n",
" 2 \n",
" RAN-27__NEU__trt_cp \n",
" 2 \n",
" SA-1459213__MCF7__trt_cp \n",
" 2 \n",
" SB-239063__NEU__trt_cp \n",
" 2 \n",
" SB-239063__PHH__trt_cp \n",
" 2 \n",
" scriptaid__ASC__trt_cp \n",
" 2 \n",
" scriptaid__HA1E__trt_cp \n",
" 2 \n",
" SQ-22536__NPC__trt_cp \n",
" 2 \n",
" STOCK1S-03920__MCF7__trt_cp \n",
" 2 \n",
" terguride__A549__trt_cp \n",
" 2 \n",
" TG-100115__VCAP__trt_cp \n",
" 2 \n",
" thiocolchicoside__NPC__trt_cp \n",
" 2 \n",
" thiocolchicoside__SKB__trt_cp \n",
" 2 \n",
" vorinostat__HA1E__trt_cp \n",
" 2 \n",
" YM-155__NPC__trt_cp \n",
" 2 \n",
" zoxazolamine__PHH__trt_cp \n",
" 2 \n",
" 1-phenylbiguanide__NPC__trt_cp \n",
" 1 \n",
" 10-hydroxycamptothecin__PHH__trt_cp \n",
" 1 \n",
" 15-delta-prostaglandin-j2__HA1E__trt_cp \n",
" 1 \n",
" 6-nitrodopamine__FIBRNPC__trt_cp \n",
" 1 \n",
" A-23187__HEPG2__trt_cp \n",
" 1 \n",
" A-23187__HUH7__trt_cp \n",
" 1 \n",
" A-443644__NPC__trt_cp \n",
" 1 \n",
" ABT-751__HT29__trt_cp \n",
" 1 \n",
" acitretin__VCAP__trt_cp \n",
" 1 \n",
" AG-592__HA1E__trt_cp \n",
" 1 \n",
" AKT-inhibitor-IV__HT29__trt_cp \n",
" 1 \n",
" alendronic-acid__NEU__trt_cp \n",
" 1 \n",
" alpha-linolenic-acid__A549__trt_cp \n",
" 1 \n",
" alpha-tocopherol__MCF7__trt_cp \n",
" 1 \n",
" alpha-tocopherol__PC3__trt_cp \n",
" 1 \n",
" alvespimycin__PHH__trt_cp \n",
" 1 \n",
" alvocidib__A549__trt_cp \n",
" 1 \n",
" amcinonide__PHH__trt_cp \n",
" 1 \n",
" amcinonide__VCAP__trt_cp \n",
" 1 \n",
" aminohippuric-acid__PC3__trt_cp \n",
" 1 \n",
" aminomethyltransferase__HA1E__trt_cp \n",
" 1 \n",
" aminopentamide__A549__trt_cp \n",
" 1 \n",
" aminopurvalanol-a__NPC__trt_cp \n",
" 1 \n",
" amiodarone__PHH__trt_cp \n",
" 1 \n",
" amisulpride__HA1E__trt_cp \n",
" 1 \n",
" amodiaquine__NEU__trt_cp \n",
" 1 \n",
" amthamine__PHH__trt_cp \n",
" 1 \n",
" anagrelide__HA1E__trt_cp \n",
" 1 \n",
" androstenol__NEU__trt_cp \n",
" 1 \n",
" anisomycin__ASC__trt_cp \n",
" 1 \n",
" anisomycin__HA1E__trt_cp \n",
" 1 \n",
" anisomycin__SKB__trt_cp \n",
" 1 \n",
" anthothecol__PHH__trt_cp \n",
" 1 \n",
" apicidin__FIBRNPC__trt_cp \n",
" 1 \n",
" apicidin__HA1E__trt_cp \n",
" 1 \n",
" apicidin__HT29__trt_cp \n",
" 1 \n",
" apicidin__NEU__trt_cp \n",
" 1 \n",
" apigenin__NEU__trt_cp \n",
" 1 \n",
" apoptosis-activator-II__HCC515__trt_cp \n",
" 1 \n",
" ARP-101__HA1E__trt_cp \n",
" 1 \n",
" AS-604850__ASC__trt_cp \n",
" 1 \n",
" AVA__HA1E__trt_cp \n",
" 1 \n",
" avrainvillamide-analog-3__A375__trt_cp \n",
" 1 \n",
" benazepril__HA1E__trt_cp \n",
" 1 \n",
" beta-alanine__NEU__trt_cp \n",
" 1 \n",
" betamethasone__PHH__trt_cp \n",
" 1 \n",
" BG-1003__NPC__trt_cp \n",
" 1 \n",
" BG-1005__NEU__trt_cp \n",
" 1 \n",
" BG-1007__NPC__trt_cp \n",
" 1 \n",
" BG-1008__NEU__trt_cp \n",
" 1 \n",
" BG-1025__NEU__trt_cp \n",
" 1 \n",
" BG-1025__NPC__trt_cp \n",
" 1 \n",
" BG-1026__NPC__trt_cp \n",
" 1 \n",
" BG-1027__NPC__trt_cp \n",
" 1 \n",
" BG-1028__NPC__trt_cp \n",
" 1 \n",
" BG-1029__NPC__trt_cp \n",
" 1 \n",
" BG-1030__NEU__trt_cp \n",
" 1 \n",
" BG-FA-0953__VCAP__trt_cp \n",
" 1 \n",
" BH3I-1__PHH__trt_cp \n",
" 1 \n",
" BI-2536__A375__trt_cp \n",
" 1 \n",
" BI-2536__A549__trt_cp \n",
" 1 \n",
" BI-2536__BT20__trt_cp \n",
" 1 \n",
" BI-2536__PC3__trt_cp \n",
" 1 \n",
" bisindolylmaleimide-ix__NEU__trt_cp \n",
" 1 \n",
" bithionol__HA1E__trt_cp \n",
" 1 \n",
" bithionol__HCC515__trt_cp \n",
" 1 \n",
" BIX-02188__VCAP__trt_cp \n",
" 1 \n",
" BML-257__NPC__trt_cp \n",
" 1 \n",
" BML-284__NPC__trt_cp \n",
" 1 \n",
" BMY-14802__NPC__trt_cp \n",
" 1 \n",
" BNTX__HT29__trt_cp \n",
" 1 \n",
" brazilin__HA1E__trt_cp \n",
" 1 \n",
" BRD-A00474148__PC3__trt_cp \n",
" 1 \n",
" BRD-A11095214__MCF7__trt_cp \n",
" 1 \n",
" BRD-A12426960__FIBRNPC__trt_cp \n",
" 1 \n",
" BRD-A16581344__VCAP__trt_cp \n",
" 1 \n",
" BRD-A21406558__MCF7__trt_cp \n",
" 1 \n",
" BRD-A35072120__FIBRNPC__trt_cp \n",
" 1 \n",
" BRD-A36411721__PHH__trt_cp \n",
" 1 \n",
" BRD-A38425832__MCF7__trt_cp \n",
" 1 \n",
" BRD-A40163033__FIBRNPC__trt_cp \n",
" 1 \n",
" BRD-A42610307__NEU__trt_cp \n",
" 1 \n",
" BRD-A43126523__HA1E__trt_cp \n",
" 1 \n",
" BRD-A51929314__HA1E__trt_cp \n",
" 1 \n",
" BRD-A58924247__HT29__trt_cp \n",
" 1 \n",
" BRD-A60386802__NEU__trt_cp \n",
" 1 \n",
" BRD-A60386802__NPC__trt_cp \n",
" 1 \n",
" BRD-A68274214__NEU__trt_cp \n",
" 1 \n",
" BRD-A72069525__HA1E__trt_cp \n",
" 1 \n",
" BRD-A73929928__A549__trt_cp \n",
" 1 \n",
" BRD-A77577770__A549__trt_cp \n",
" 1 \n",
" BRD-A79058669__NEU__trt_cp \n",
" 1 \n",
" BRD-A81936046__VCAP__trt_cp \n",
" 1 \n",
" BRD-A84445767__MCF7__trt_cp \n",
" 1 \n",
" BRD-A86146706__NEU__trt_cp \n",
" 1 \n",
" BRD-A93015352__NEU__trt_cp \n",
" 1 \n",
" BRD-A93015352__VCAP__trt_cp \n",
" 1 \n",
" BRD-A94675310__HT29__trt_cp \n",
" 1 \n",
" BRD-A95820578__NEU__trt_cp \n",
" 1 \n",
" BRD-A95820578__VCAP__trt_cp \n",
" 1 \n",
" BRD-A95937159__NPC__trt_cp \n",
" 1 \n",
" BRD-A98444709__A549__trt_cp \n",
" 1 \n",
" BRD-K00381581__A549__trt_cp \n",
" 1 \n",
" BRD-K00381581__NEU__trt_cp \n",
" 1 \n",
" BRD-K00835201__NEU__trt_cp \n",
" 1 \n",
" BRD-K00954209__A549__trt_cp \n",
" 1 \n",
" BRD-K01265221__VCAP__trt_cp \n",
" 1 \n",
" BRD-K01477275__NPC__trt_cp \n",
" 1 \n",
" BRD-K02025760__PC3__trt_cp \n",
" 1 \n",
" BRD-K02117849__NEU__trt_cp \n",
" 1 \n",
" BRD-K02223034__A549__trt_cp \n",
" 1 \n",
" BRD-K02223034__SKB__trt_cp \n",
" 1 \n",
" BRD-K03358980__VCAP__trt_cp \n",
" 1 \n",
" BRD-K03601405__VCAP__trt_cp \n",
" 1 \n",
" BRD-K04534322__PHH__trt_cp \n",
" 1 \n",
" BRD-K04534322__SKB__trt_cp \n",
" 1 \n",
" BRD-K04676863__MCF7__trt_cp \n",
" 1 \n",
" BRD-K05002121__A375__trt_cp \n",
" 1 \n",
" BRD-K05353139__HT29__trt_cp \n",
" 1 \n",
" BRD-K05402890__HA1E__trt_cp \n",
" 1 \n",
" BRD-K06592610__VCAP__trt_cp \n",
" 1 \n",
" BRD-K07061353__VCAP__trt_cp \n",
" 1 \n",
" BRD-K07161233__NEU__trt_cp \n",
" 1 \n",
" BRD-K07259155__MCF7__trt_cp \n",
" 1 \n",
" BRD-K07877311__PC3__trt_cp \n",
" 1 \n",
" BRD-K08438429__A549__trt_cp \n",
" 1 \n",
" BRD-K09460252__SKB__trt_cp \n",
" 1 \n",
" BRD-K10361096__A375__trt_cp \n",
" 1 \n",
" BRD-K10846167__PC3__trt_cp \n",
" 1 \n",
" BRD-K13146765__HA1E__trt_cp \n",
" 1 \n",
" BRD-K13872703__ASC__trt_cp \n",
" 1 \n",
" BRD-K14316227__NPC__trt_cp \n",
" 1 \n",
" BRD-K14704318__MCF7__trt_cp \n",
" 1 \n",
" BRD-K14842454__NEU__trt_cp \n",
" 1 \n",
" BRD-K15524596__NEU__trt_cp \n",
" 1 \n",
" BRD-K16346331__PHH__trt_cp \n",
" 1 \n",
" BRD-K16410418__HT29__trt_cp \n",
" 1 \n",
" BRD-K17203693__HA1E__trt_cp \n",
" 1 \n",
" BRD-K18163752__VCAP__trt_cp \n",
" 1 \n",
" BRD-K18545493__VCAP__trt_cp \n",
" 1 \n",
" BRD-K18722736__NEU__trt_cp \n",
" 1 \n",
" BRD-K18726304__MCF7__trt_cp \n",
" 1 \n",
" BRD-K19290969__A549__trt_cp \n",
" 1 \n",
" BRD-K19433082__HT29__trt_cp \n",
" 1 \n",
" BRD-K19653414__FIBRNPC__trt_cp \n",
" 1 \n",
" BRD-K19696793__MCF7__trt_cp \n",
" 1 \n",
" BRD-K19735876__A375__trt_cp \n",
" 1 \n",
" BRD-K20401833__MCF7__trt_cp \n",
" 1 \n",
" BRD-K21064560__VCAP__trt_cp \n",
" 1 \n",
" BRD-K21672423__SKB__trt_cp \n",
" 1 \n",
" BRD-K22006123__HA1E__trt_cp \n",
" 1 \n",
" BRD-K22261046__NEU__trt_cp \n",
" 1 \n",
" BRD-K23027438__A549__trt_cp \n",
" 1 \n",
" BRD-K23165181__VCAP__trt_cp \n",
" 1 \n",
" BRD-K23985857__HT29__trt_cp \n",
" 1 \n",
" BRD-K24053449__A549__trt_cp \n",
" 1 \n",
" BRD-K24053449__MCF7__trt_cp \n",
" 1 \n",
" BRD-K24156250__VCAP__trt_cp \n",
" 1 \n",
" BRD-K24205443__VCAP__trt_cp \n",
" 1 \n",
" BRD-K24754728__A549__trt_cp \n",
" 1 \n",
" BRD-K25731886__ASC__trt_cp \n",
" 1 \n",
" BRD-K25731886__PHH__trt_cp \n",
" 1 \n",
" BRD-K26510616__PC3__trt_cp \n",
" 1 \n",
" BRD-K26767475__HT29__trt_cp \n",
" 1 \n",
" BRD-K28452084__VCAP__trt_cp \n",
" 1 \n",
" BRD-K28772322__VCAP__trt_cp \n",
" 1 \n",
" BRD-K28841686__NEU__trt_cp \n",
" 1 \n",
" BRD-K29423519__A549__trt_cp \n",
" 1 \n",
" BRD-K30126976__A375__trt_cp \n",
" 1 \n",
" BRD-K30704475__NEU__trt_cp \n",
" 1 \n",
" BRD-K31290914__A375__trt_cp \n",
" 1 \n",
" BRD-K31600199__A549__trt_cp \n",
" 1 \n",
" BRD-K32598858__PHH__trt_cp \n",
" 1 \n",
" BRD-K32827536__PC3__trt_cp \n",
" 1 \n",
" BRD-K32896438__MCF7__trt_cp \n",
" 1 \n",
" BRD-K33182644__MCF7__trt_cp \n",
" 1 \n",
" BRD-K33676730__PHH__trt_cp \n",
" 1 \n",
" BRD-K33743361__VCAP__trt_cp \n",
" 1 \n",
" BRD-K34547533__PC3__trt_cp \n",
" 1 \n",
" BRD-K35254025__A549__trt_cp \n",
" 1 \n",
" BRD-K35568648__PHH__trt_cp \n",
" 1 \n",
" BRD-K35568648__SKB__trt_cp \n",
" 1 \n",
" BRD-K35716340__HT29__trt_cp \n",
" 1 \n",
" BRD-K36354764__MCF7__trt_cp \n",
" 1 \n",
" BRD-K36620425__VCAP__trt_cp \n",
" 1 \n",
" BRD-K36767861__PHH__trt_cp \n",
" 1 \n",
" BRD-K36864553__HT29__trt_cp \n",
" 1 \n",
" BRD-K37340241__A549__trt_cp \n",
" 1 \n",
" BRD-K37340241__NPC__trt_cp \n",
" 1 \n",
" BRD-K37724988__PC3__trt_cp \n",
" 1 \n",
" BRD-K37762845__NEU__trt_cp \n",
" 1 \n",
" BRD-K38294617__NEU__trt_cp \n",
" 1 \n",
" BRD-K39345836__HT29__trt_cp \n",
" 1 \n",
" BRD-K39799535__A549__trt_cp \n",
" 1 \n",
" BRD-K40185230__A549__trt_cp \n",
" 1 \n",
" BRD-K40758391__HA1E__trt_cp \n",
" 1 \n",
" BRD-K41925105__PC3__trt_cp \n",
" 1 \n",
" BRD-K43253317__NEU__trt_cp \n",
" 1 \n",
" BRD-K43267173__A549__trt_cp \n",
" 1 \n",
" BRD-K44261129__HT29__trt_cp \n",
" 1 \n",
" BRD-K44366801__VCAP__trt_cp \n",
" 1 \n",
" BRD-K44575778__A549__trt_cp \n",
" 1 \n",
" BRD-K45114207__A549__trt_cp \n",
" 1 \n",
" BRD-K45114207__NEU__trt_cp \n",
" 1 \n",
" BRD-K45205755__A549__trt_cp \n",
" 1 \n",
" BRD-K45230579__A549__trt_cp \n",
" 1 \n",
" BRD-K45627302__MCF7__trt_cp \n",
" 1 \n",
" BRD-K45842176__NEU__trt_cp \n",
" 1 \n",
" BRD-K46814258__VCAP__trt_cp \n",
" 1 \n",
" BRD-K47512679__NPC__trt_cp \n",
" 1 \n",
" BRD-K48199208__HA1E__trt_cp \n",
" 1 \n",
" BRD-K48598367__NEU__trt_cp \n",
" 1 \n",
" BRD-K48673964__NEU__trt_cp \n",
" 1 \n",
" BRD-K48844671__PC3__trt_cp \n",
" 1 \n",
" BRD-K49403449__VCAP__trt_cp \n",
" 1 \n",
" BRD-K49562544__HA1E__trt_cp \n",
" 1 \n",
" BRD-K49861754__NEU__trt_cp \n",
" 1 \n",
" BRD-K50748030__MCF7__trt_cp \n",
" 1 \n",
" BRD-K51696048__ASC__trt_cp \n",
" 1 \n",
" BRD-K53335770__MCF7__trt_cp \n",
" 1 \n",
" BRD-K53833301__HA1E__trt_cp \n",
" 1 \n",
" BRD-K54159704__NEU__trt_cp \n",
" 1 \n",
" BRD-K54558492__VCAP__trt_cp \n",
" 1 \n",
" BRD-K57064803__MCF7__trt_cp \n",
" 1 \n",
" BRD-K57353465__A375__trt_cp \n",
" 1 \n",
" BRD-K59472190__MCF7__trt_cp \n",
" 1 \n",
" BRD-K60379529__A549__trt_cp \n",
" 1 \n",
" BRD-K60870698__A375__trt_cp \n",
" 1 \n",
" BRD-K60870698__A549__trt_cp \n",
" 1 \n",
" BRD-K60870698__HA1E__trt_cp \n",
" 1 \n",
" BRD-K61359235__PC3__trt_cp \n",
" 1 \n",
" BRD-K62056344__HUH7__trt_cp \n",
" 1 \n",
" BRD-K62242359__HT29__trt_cp \n",
" 1 \n",
" BRD-K62578746__MCF7__trt_cp \n",
" 1 \n",
" BRD-K63000292__MCF7__trt_cp \n",
" 1 \n",
" BRD-K63770300__HA1E__trt_cp \n",
" 1 \n",
" BRD-K64985742__A549__trt_cp \n",
" 1 \n",
" BRD-K66426634__A549__trt_cp \n",
" 1 \n",
" BRD-K66658536__NEU__trt_cp \n",
" 1 \n",
" BRD-K66884694__MCF7__trt_cp \n",
" 1 \n",
" BRD-K66884694__VCAP__trt_cp \n",
" 1 \n",
" BRD-K67010098__NEU__trt_cp \n",
" 1 \n",
" BRD-K67118123__PC3__trt_cp \n",
" 1 \n",
" BRD-K67470788__NEU__trt_cp \n",
" 1 \n",
" BRD-K67514995__NEU__trt_cp \n",
" 1 \n",
" BRD-K67774729__HA1E__trt_cp \n",
" 1 \n",
" BRD-K67925802__VCAP__trt_cp \n",
" 1 \n",
" BRD-K68504618__NPC__trt_cp \n",
" 1 \n",
" BRD-K69406317__NEU__trt_cp \n",
" 1 \n",
" BRD-K69516039__MCF7__trt_cp \n",
" 1 \n",
" BRD-K69795440__A549__trt_cp \n",
" 1 \n",
" BRD-K70891562__A549__trt_cp \n",
" 1 \n",
" BRD-K70917163__VCAP__trt_cp \n",
" 1 \n",
" BRD-K71265179__HT29__trt_cp \n",
" 1 \n",
" BRD-K71292008__ASC__trt_cp \n",
" 1 \n",
" BRD-K73125384__A549__trt_cp \n",
" 1 \n",
" BRD-K73143528__HT29__trt_cp \n",
" 1 \n",
" BRD-K73276569__A549__trt_cp \n",
" 1 \n",
" BRD-K74109131__A549__trt_cp \n",
" 1 \n",
" BRD-K74109131__NEU__trt_cp \n",
" 1 \n",
" BRD-K74534237__PHH__trt_cp \n",
" 1 \n",
" BRD-K75264577__NEU__trt_cp \n",
" 1 \n",
" BRD-K75329208__NEU__trt_cp \n",
" 1 \n",
" BRD-K75641083__A549__trt_cp \n",
" 1 \n",
" BRD-K76079827__PC3__trt_cp \n",
" 1 \n",
" BRD-K76236182__NEU__trt_cp \n",
" 1 \n",
" BRD-K76264608__HT29__trt_cp \n",
" 1 \n",
" BRD-K76691125__VCAP__trt_cp \n",
" 1 \n",
" BRD-K76926998__PHH__trt_cp \n",
" 1 \n",
" BRD-K77547920__VCAP__trt_cp \n",
" 1 \n",
" BRD-K78062244__NEU__trt_cp \n",
" 1 \n",
" BRD-K78133682__A375__trt_cp \n",
" 1 \n",
" BRD-K78133682__HT29__trt_cp \n",
" 1 \n",
" BRD-K79532217__NEU__trt_cp \n",
" 1 \n",
" BRD-K79657514__NPC__trt_cp \n",
" 1 \n",
" BRD-K80169513__NPC__trt_cp \n",
" 1 \n",
" BRD-K80962769__MCF7__trt_cp \n",
" 1 \n",
" BRD-K81408913__NPC__trt_cp \n",
" 1 \n",
" BRD-K82732294__A549__trt_cp \n",
" 1 \n",
" BRD-K82732294__MCF7__trt_cp \n",
" 1 \n",
" BRD-K82732294__VCAP__trt_cp \n",
" 1 \n",
" BRD-K82971429__PHH__trt_cp \n",
" 1 \n",
" BRD-K83589469__HA1E__trt_cp \n",
" 1 \n",
" BRD-K83694683__HEPG2__trt_cp \n",
" 1 \n",
" BRD-K83694683__MCF7__trt_cp \n",
" 1 \n",
" BRD-K84203638__A375__trt_cp \n",
" 1 \n",
" BRD-K85174275__MCF7__trt_cp \n",
" 1 \n",
" BRD-K85205404__NPC__trt_cp \n",
" 1 \n",
" BRD-K85266146__NEU__trt_cp \n",
" 1 \n",
" BRD-K85275009__A549__trt_cp \n",
" 1 \n",
" BRD-K85694079__NEU__trt_cp \n",
" 1 \n",
" BRD-K86048057__NPC__trt_cp \n",
" 1 \n",
" BRD-K86671899__A375__trt_cp \n",
" 1 \n",
" BRD-K88373420__NEU__trt_cp \n",
" 1 \n",
" BRD-K88542532__VCAP__trt_cp \n",
" 1 \n",
" BRD-K88556033__A549__trt_cp \n",
" 1 \n",
" BRD-K88822846__NEU__trt_cp \n",
" 1 \n",
" BRD-K88899793__NEU__trt_cp \n",
" 1 \n",
" BRD-K89107430__VCAP__trt_cp \n",
" 1 \n",
" BRD-K89224880__VCAP__trt_cp \n",
" 1 \n",
" BRD-K89326053__VCAP__trt_cp \n",
" 1 \n",
" BRD-K90734091__HT29__trt_cp \n",
" 1 \n",
" BRD-K91691979__PC3__trt_cp \n",
" 1 \n",
" BRD-K91781484__A549__trt_cp \n",
" 1 \n",
" BRD-K91781484__NEU__trt_cp \n",
" 1 \n",
" BRD-K92033419__A549__trt_cp \n",
" 1 \n",
" BRD-K92202821__PC3__trt_cp \n",
" 1 \n",
" BRD-K92302554__MCF7__trt_cp \n",
" 1 \n",
" BRD-K93541117__NEU__trt_cp \n",
" 1 \n",
" BRD-K93610587__HT29__trt_cp \n",
" 1 \n",
" BRD-K93760529__A549__trt_cp \n",
" 1 \n",
" BRD-K95037415__VCAP__trt_cp \n",
" 1 \n",
" BRD-K95352812__HA1E__trt_cp \n",
" 1 \n",
" BRD-K95482240__A549__trt_cp \n",
" 1 \n",
" BRD-K95789946__HA1E__trt_cp \n",
" 1 \n",
" BRD-K95895342__ASC__trt_cp \n",
" 1 \n",
" BRD-K96041907__HT29__trt_cp \n",
" 1 \n",
" BRD-K96194181__A549__trt_cp \n",
" 1 \n",
" BRD-K96703623__HT29__trt_cp \n",
" 1 \n",
" BRD-K97149069__SKB__trt_cp \n",
" 1 \n",
" BRD-K97255584__VCAP__trt_cp \n",
" 1 \n",
" BRD-K97936712__VCAP__trt_cp \n",
" 1 \n",
" BRD-K98645985__A549__trt_cp \n",
" 1 \n",
" BRD-K98731749__VCAP__trt_cp \n",
" 1 \n",
" BRD-K98945308__NEU__trt_cp \n",
" 1 \n",
" BRD-K98991361__A549__trt_cp \n",
" 1 \n",
" BRD-K99636700__HCC515__trt_cp \n",
" 1 \n",
" BRD-K99737413__A375__trt_cp \n",
" 1 \n",
" BRD-K99756483__PC3__trt_cp \n",
" 1 \n",
" brefeldin-a__MCF7__trt_cp \n",
" 1 \n",
" brefeldin-a__PC3__trt_cp \n",
" 1 \n",
" BRL-37344__HA1E__trt_cp \n",
" 1 \n",
" brucine__PC3__trt_cp \n",
" 1 \n",
" budesonide__HCC515__trt_cp \n",
" 1 \n",
" bufalin__HA1E__trt_cp \n",
" 1 \n",
" buphenine__HCC515__trt_cp \n",
" 1 \n",
" butoconazole__HCC515__trt_cp \n",
" 1 \n",
" butoconazole__PHH__trt_cp \n",
" 1 \n",
" BX-795__HT29__trt_cp \n",
" 1 \n",
" C2-dihydroceramide__NEU__trt_cp \n",
" 1 \n",
" CA-074-Me__A375__trt_cp \n",
" 1 \n",
" caffeic-acid__NEU__trt_cp \n",
" 1 \n",
" calmidazolium__ASC__trt_cp \n",
" 1 \n",
" calycanthine__A549__trt_cp \n",
" 1 \n",
" camptothecin__MCF7__trt_cp \n",
" 1 \n",
" carbetocin__VCAP__trt_cp \n",
" 1 \n",
" CAY-10415__VCAP__trt_cp \n",
" 1 \n",
" CCMQ__ASC__trt_cp \n",
" 1 \n",
" cefotiam__MCF7__trt_cp \n",
" 1 \n",
" celecoxib__A549__trt_cp \n",
" 1 \n",
" cephaeline__HA1E__trt_cp \n",
" 1 \n",
" cerivastatin__PC3__trt_cp \n",
" 1 \n",
" CFM-1571__HCC515__trt_cp \n",
" 1 \n",
" CGS-21680__ASC__trt_cp \n",
" 1 \n",
" chelidonine__HT29__trt_cp \n",
" 1 \n",
" chloroxine__ASC__trt_cp \n",
" 1 \n",
" chloroxine__HA1E__trt_cp \n",
" 1 \n",
" ciglitazone__SKB__trt_cp \n",
" 1 \n",
" cinalukast__PHH__trt_cp \n",
" 1 \n",
" cinobufagin__HA1E__trt_cp \n",
" 1 \n",
" CL-82198__MCF7__trt_cp \n",
" 1 \n",
" clioquinol__HT29__trt_cp \n",
" 1 \n",
" CMPD-1__A375__trt_cp \n",
" 1 \n",
" cortisone-acetate__PC3__trt_cp \n",
" 1 \n",
" crizotinib__NPC__trt_cp \n",
" 1 \n",
" CS-110266__ASC__trt_cp \n",
" 1 \n",
" CT-200783__VCAP__trt_cp \n",
" 1 \n",
" cucurbitacin-i__HT29__trt_cp \n",
" 1 \n",
" cycloheximide__ASC__trt_cp \n",
" 1 \n",
" cycloheximide__NEU__trt_cp \n",
" 1 \n",
" cycloheximide__SKB__trt_cp \n",
" 1 \n",
" cyclopentene__A549__trt_cp \n",
" 1 \n",
" cymarin__HA1E__trt_cp \n",
" 1 \n",
" cymarin__NPC__trt_cp \n",
" 1 \n",
" cyproterone__HCC515__trt_cp \n",
" 1 \n",
" cytochalasin-d__MCF7__trt_cp \n",
" 1 \n",
" dactinomycin__VCAP__trt_cp \n",
" 1 \n",
" dantrolene__PHH__trt_cp \n",
" 1 \n",
" danusertib__NEU__trt_cp \n",
" 1 \n",
" daunorubicin__NEU__trt_cp \n",
" 1 \n",
" daunorubicin__NPC__trt_cp \n",
" 1 \n",
" DCEBIO__PHH__trt_cp \n",
" 1 \n",
" decitabine__NPC__trt_cp \n",
" 1 \n",
" dehydrocholate__SKB__trt_cp \n",
" 1 \n",
" desoxycortone__NEU__trt_cp \n",
" 1 \n",
" desoxycortone__SKB__trt_cp \n",
" 1 \n",
" dexamethasone__PHH__trt_cp \n",
" 1 \n",
" dexrazoxane__PHH__trt_cp \n",
" 1 \n",
" dextromethorphan__NPC__trt_cp \n",
" 1 \n",
" dibutyrylcyclic-gmp__A549__trt_cp \n",
" 1 \n",
" dicyclohexylurea__SKB__trt_cp \n",
" 1 \n",
" digitoxigenin__HA1E__trt_cp \n",
" 1 \n",
" digoxigenin__HA1E__trt_cp \n",
" 1 \n",
" digoxin__HA1E__trt_cp \n",
" 1 \n",
" dihydroergocristine__HA1E__trt_cp \n",
" 1 \n",
" dihydroergotamine__PHH__trt_cp \n",
" 1 \n",
" diltiazem__ASC__trt_cp \n",
" 1 \n",
" diosmin__PC3__trt_cp \n",
" 1 \n",
" diphenyleneiodonium__MCF7__trt_cp \n",
" 1 \n",
" dipyridamole__PHH__trt_cp \n",
" 1 \n",
" dorsomorphin__HCC515__trt_cp \n",
" 1 \n",
" doxercalciferol__NEU__trt_cp \n",
" 1 \n",
" doxorubicin__VCAP__trt_cp \n",
" 1 \n",
" doxylamine__MCF7__trt_cp \n",
" 1 \n",
" doxylamine__VCAP__trt_cp \n",
" 1 \n",
" EI-231__NEU__trt_cp \n",
" 1 \n",
" EMF-bca1-16__VCAP__trt_cp \n",
" 1 \n",
" EMF-sumo1-9__ASC__trt_cp \n",
" 1 \n",
" emodic-acid__HA1E__trt_cp \n",
" 1 \n",
" ENMD-2076__A375__trt_cp \n",
" 1 \n",
" entinostat__HEPG2__trt_cp \n",
" 1 \n",
" ephedrine__FIBRNPC__trt_cp \n",
" 1 \n",
" epitestosterone__VCAP__trt_cp \n",
" 1 \n",
" eplerenone__SKB__trt_cp \n",
" 1 \n",
" ER-27319__NPC__trt_cp \n",
" 1 \n",
" ER-27319__PHH__trt_cp \n",
" 1 \n",
" esculin__SKB__trt_cp \n",
" 1 \n",
" everolimus__A549__trt_cp \n",
" 1 \n",
" evodiamine__HT29__trt_cp \n",
" 1 \n",
" F-1061-0166__NEU__trt_cp \n",
" 1 \n",
" FCCP__HCC515__trt_cp \n",
" 1 \n",
" FCCP__MCF7__trt_cp \n",
" 1 \n",
" fenoterol__HA1E__trt_cp \n",
" 1 \n",
" fenretinide__A549__trt_cp \n",
" 1 \n",
" fenretinide__NPC__trt_cp \n",
" 1 \n",
" fluconazole__HCC515__trt_cp \n",
" 1 \n",
" fludarabine__NEU__trt_cp \n",
" 1 \n",
" fludrocortisone-acetate__A375__trt_cp \n",
" 1 \n",
" fluocinolone-acetonide__HT29__trt_cp \n",
" 1 \n",
" fluprostenol__VCAP__trt_cp \n",
" 1 \n",
" formestane__VCAP__trt_cp \n",
" 1 \n",
" formoterol__SKB__trt_cp \n",
" 1 \n",
" FPL-64176__PHH__trt_cp \n",
" 1 \n",
" gitoxigenin__NPC__trt_cp \n",
" 1 \n",
" glycocholic-acid__PHH__trt_cp \n",
" 1 \n",
" glycodeoxycholic-acid__NEU__trt_cp \n",
" 1 \n",
" GR-159897__HCC515__trt_cp \n",
" 1 \n",
" GR-206__ASC__trt_cp \n",
" 1 \n",
" GR-235__NEU__trt_cp \n",
" 1 \n",
" GSK-3-inhibitor-II__HA1E__trt_cp \n",
" 1 \n",
" GSK-3-inhibitor-IX__SKBR3__trt_cp \n",
" 1 \n",
" GSK-429286A__HS578T__trt_cp \n",
" 1 \n",
" GSK-461364__VCAP__trt_cp \n",
" 1 \n",
" GW-1929__NPC__trt_cp \n",
" 1 \n",
" GW-1929__VCAP__trt_cp \n",
" 1 \n",
" GW-7647__ASC__trt_cp \n",
" 1 \n",
" GW-9508__HA1E__trt_cp \n",
" 1 \n",
" HA-14-1__NEU__trt_cp \n",
" 1 \n",
" hexamethyleneamiloride__PHH__trt_cp \n",
" 1 \n",
" HO-013__A549__trt_cp \n",
" 1 \n",
" HO-013__SKB__trt_cp \n",
" 1 \n",
" homoharringtonine__SKB__trt_cp \n",
" 1 \n",
" HU-211__NPC__trt_cp \n",
" 1 \n",
" hydrocortisone-valerate__ASC__trt_cp \n",
" 1 \n",
" icilin__NPC__trt_cp \n",
" 1 \n",
" IKK-16__HCC515__trt_cp \n",
" 1 \n",
" IKK-2-inhibitor-V__HEPG2__trt_cp \n",
" 1 \n",
" IKK-2-inhibitor-V__HUH7__trt_cp \n",
" 1 \n",
" ipratropium__A549__trt_cp \n",
" 1 \n",
" ipratropium__NPC__trt_cp \n",
" 1 \n",
" irsogladine__HA1E__trt_cp \n",
" 1 \n",
" isocarboxazid__HCC515__trt_cp \n",
" 1 \n",
" ixazomib__NKDBA__trt_cp \n",
" 1 \n",
" J-104129__HCC515__trt_cp \n",
" 1 \n",
" JAS07-005__VCAP__trt_cp \n",
" 1 \n",
" JX-401__PHH__trt_cp \n",
" 1 \n",
" KF-38789__NPC__trt_cp \n",
" 1 \n",
" khellin__PC3__trt_cp \n",
" 1 \n",
" KI-8751__HA1E__trt_cp \n",
" 1 \n",
" KI-8751__PHH__trt_cp \n",
" 1 \n",
" kinetin-riboside__A375__trt_cp \n",
" 1 \n",
" KM-00799__A549__trt_cp \n",
" 1 \n",
" KM-00927__MCF7__trt_cp \n",
" 1 \n",
" KM-01366__A549__trt_cp \n",
" 1 \n",
" KM-04644SC__A549__trt_cp \n",
" 1 \n",
" KU-0060648__HCC515__trt_cp \n",
" 1 \n",
" KU-0060648__PC3__trt_cp \n",
" 1 \n",
" KU-C103656__A549__trt_cp \n",
" 1 \n",
" KU-C103898N__A549__trt_cp \n",
" 1 \n",
" KU-C104140__A549__trt_cp \n",
" 1 \n",
" KUC103424N__A549__trt_cp \n",
" 1 \n",
" L-161982__PHH__trt_cp \n",
" 1 \n",
" L-168049__VCAP__trt_cp \n",
" 1 \n",
" L-701252__ASC__trt_cp \n",
" 1 \n",
" lamotrigine__NEU__trt_cp \n",
" 1 \n",
" lanatoside-c__VCAP__trt_cp \n",
" 1 \n",
" lasalocid__ASC__trt_cp \n",
" 1 \n",
" latrunculin-b__A549__trt_cp \n",
" 1 \n",
" LBH-589__NEU__trt_cp \n",
" 1 \n",
" LBH-589__NPC__trt_cp \n",
" 1 \n",
" LDN-193189__MCF10A__trt_cp \n",
" 1 \n",
" letrozole__A549__trt_cp \n",
" 1 \n",
" leucodin__HA1E__trt_cp \n",
" 1 \n",
" linifanib__PHH__trt_cp \n",
" 1 \n",
" lobeline__MCF7__trt_cp \n",
" 1 \n",
" lobendazole__PHH__trt_cp \n",
" 1 \n",
" lobendazole__SKB__trt_cp \n",
" 1 \n",
" LY-165163__NEU__trt_cp \n",
" 1 \n",
" LY-2140023__VCAP__trt_cp \n",
" 1 \n",
" LY-2183240__HT29__trt_cp \n",
" 1 \n",
" LY-2183240__NPC__trt_cp \n",
" 1 \n",
" LY-225910__VCAP__trt_cp \n",
" 1 \n",
" LY-341495__HA1E__trt_cp \n",
" 1 \n",
" M-344__NPC__trt_cp \n",
" 1 \n",
" m-3M3FBS__A549__trt_cp \n",
" 1 \n",
" mafenide__A549__trt_cp \n",
" 1 \n",
" malonoben__HA1E__trt_cp \n",
" 1 \n",
" MAZ-51__HT29__trt_cp \n",
" 1 \n",
" MD-II-038__NPC__trt_cp \n",
" 1 \n",
" meclizine__NPC__trt_cp \n",
" 1 \n",
" mefenamic-acid__PHH__trt_cp \n",
" 1 \n",
" mefenamic-acid__VCAP__trt_cp \n",
" 1 \n",
" melperone__HCC515__trt_cp \n",
" 1 \n",
" mepenzolate__PC3__trt_cp \n",
" 1 \n",
" methyl-2,5-dihydroxycinnamate__HA1E__trt_cp \n",
" 1 \n",
" methyl-2,5-dihydroxycinnamate__NPC__trt_cp \n",
" 1 \n",
" methylene-blue__HA1E__trt_cp \n",
" 1 \n",
" mevastatin__A549__trt_cp \n",
" 1 \n",
" mexiletine__HA1E__trt_cp \n",
" 1 \n",
" MG-132__VCAP__trt_cp \n",
" 1 \n",
" mifepristone__MCF7__trt_cp \n",
" 1 \n",
" milrinone__PHH__trt_cp \n",
" 1 \n",
" mirin__VCAP__trt_cp \n",
" 1 \n",
" mirtazapine__SKB__trt_cp \n",
" 1 \n",
" mitoxantrone__HT29__trt_cp \n",
" 1 \n",
" MK-1775__HT29__trt_cp \n",
" 1 \n",
" mocetinostat__ASC__trt_cp \n",
" 1 \n",
" mocimycin__A549__trt_cp \n",
" 1 \n",
" mometasone__PHH__trt_cp \n",
" 1 \n",
" monensin__PC3__trt_cp \n",
" 1 \n",
" motesanib__HS578T__trt_cp \n",
" 1 \n",
" MPEP__FIBRNPC__trt_cp \n",
" 1 \n",
" MRS-1220__HA1E__trt_cp \n",
" 1 \n",
" MRS-1845__HCC515__trt_cp \n",
" 1 \n",
" n-bromoacetyltryptamine__FIBRNPC__trt_cp \n",
" 1 \n",
" napelline__HT29__trt_cp \n",
" 1 \n",
" naproxen__PC3__trt_cp \n",
" 1 \n",
" narciclasine__A375__trt_cp \n",
" 1 \n",
" narciclasine__HA1E__trt_cp \n",
" 1 \n",
" narciclasine__HT29__trt_cp \n",
" 1 \n",
" nateglinide__PHH__trt_cp \n",
" 1 \n",
" NCH-51__NPC__trt_cp \n",
" 1 \n",
" NGB-2904__SKB__trt_cp \n",
" 1 \n",
" nicergoline__A549__trt_cp \n",
" 1 \n",
" niclosamide__HCC515__trt_cp \n",
" 1 \n",
" nimesulide__NEU__trt_cp \n",
" 1 \n",
" NNC-711__VCAP__trt_cp \n",
" 1 \n",
" nocodazole__FIBRNPC__trt_cp \n",
" 1 \n",
" nocodazole__NPC__trt_cp \n",
" 1 \n",
" NS-3694__VCAP__trt_cp \n",
" 1 \n",
" NSC-3852__HA1E__trt_cp \n",
" 1 \n",
" NSC-632839__VCAP__trt_cp \n",
" 1 \n",
" NSC-663284__HA1E__trt_cp \n",
" 1 \n",
" NSC-94258__MCF7__trt_cp \n",
" 1 \n",
" ofloxacin__VCAP__trt_cp \n",
" 1 \n",
" ON-01910__BT20__trt_cp \n",
" 1 \n",
" ON-01910__VCAP__trt_cp \n",
" 1 \n",
" orphenadrine__HCC515__trt_cp \n",
" 1 \n",
" ouabain__HA1E__trt_cp \n",
" 1 \n",
" ouabain__NEU__trt_cp \n",
" 1 \n",
" oxamflatin__NEU__trt_cp \n",
" 1 \n",
" oxamflatin__NPC__trt_cp \n",
" 1 \n",
" oxcarbazepine__MCF7__trt_cp \n",
" 1 \n",
" PAC-1__A375__trt_cp \n",
" 1 \n",
" palmitoylethanolamide__NPC__trt_cp \n",
" 1 \n",
" panobinostat__ASC__trt_cp \n",
" 1 \n",
" panobinostat__HCC515__trt_cp \n",
" 1 \n",
" panobinostat__MCF7__trt_cp \n",
" 1 \n",
" parecoxib__VCAP__trt_cp \n",
" 1 \n",
" paroxetine__PHH__trt_cp \n",
" 1 \n",
" PCI-24781__HCC515__trt_cp \n",
" 1 \n",
" PCI-34051__NEU__trt_cp \n",
" 1 \n",
" PD-0325901__BT20__trt_cp \n",
" 1 \n",
" PD-0325901__HS578T__trt_cp \n",
" 1 \n",
" PD-0325901__MDAMB231__trt_cp \n",
" 1 \n",
" PD-198306__HA1E__trt_cp \n",
" 1 \n",
" PD-407824__HA1E__trt_cp \n",
" 1 \n",
" PD-407824__PHH__trt_cp \n",
" 1 \n",
" penfluridol__NPC__trt_cp \n",
" 1 \n",
" perindopril__PHH__trt_cp \n",
" 1 \n",
" periplocymarin__HA1E__trt_cp \n",
" 1 \n",
" peruvoside__VCAP__trt_cp \n",
" 1 \n",
" PHA-665752__MCF10A__trt_cp \n",
" 1 \n",
" phentolamine__A549__trt_cp \n",
" 1 \n",
" phenylbutazone__HCC515__trt_cp \n",
" 1 \n",
" physostigmine__PHH__trt_cp \n",
" 1 \n",
" PIK-75__PHH__trt_cp \n",
" 1 \n",
" pirarubicin__NEU__trt_cp \n",
" 1 \n",
" pivmecillinam__A549__trt_cp \n",
" 1 \n",
" PNU-22394__VCAP__trt_cp \n",
" 1 \n",
" podophyllotoxin__NPC__trt_cp \n",
" 1 \n",
" prednisolone__PHH__trt_cp \n",
" 1 \n",
" proadifen__ASC__trt_cp \n",
" 1 \n",
" proadifen__NEU__trt_cp \n",
" 1 \n",
" proadifen__NPC__trt_cp \n",
" 1 \n",
" probucol__VCAP__trt_cp \n",
" 1 \n",
" procainamide__VCAP__trt_cp \n",
" 1 \n",
" procaterol__HCC515__trt_cp \n",
" 1 \n",
" PSH-003__HT29__trt_cp \n",
" 1 \n",
" puromycin__VCAP__trt_cp \n",
" 1 \n",
" pyrvinium__MCF7__trt_cp \n",
" 1 \n",
" QL-X-138__MCF10A__trt_cp \n",
" 1 \n",
" QL-X-138__NEU__trt_cp \n",
" 1 \n",
" quinapril__NEU__trt_cp \n",
" 1 \n",
" quinapril__NPC__trt_cp \n",
" 1 \n",
" R-59022__HA1E__trt_cp \n",
" 1 \n",
" ramipril__A549__trt_cp \n",
" 1 \n",
" RDR-01440SC__VCAP__trt_cp \n",
" 1 \n",
" remoxipride__A549__trt_cp \n",
" 1 \n",
" resmethrin__HT29__trt_cp \n",
" 1 \n",
" rifapentine__VCAP__trt_cp \n",
" 1 \n",
" rizatriptan__SKB__trt_cp \n",
" 1 \n",
" Ro-08-2750__HA1E__trt_cp \n",
" 1 \n",
" Ro-15-4513__VCAP__trt_cp \n",
" 1 \n",
" Ro-19-4605__HCC515__trt_cp \n",
" 1 \n",
" rosmarinic-acid__NPC__trt_cp \n",
" 1 \n",
" RS-45041-190__VCAP__trt_cp \n",
" 1 \n",
" RU-28318__HA1E__trt_cp \n",
" 1 \n",
" ryuvidine__NPC__trt_cp \n",
" 1 \n",
" SA-1447005__A549__trt_cp \n",
" 1 \n",
" SA-1447005__VCAP__trt_cp \n",
" 1 \n",
" SA-1456456__NKDBA__trt_cp \n",
" 1 \n",
" SA-1457415__NKDBA__trt_cp \n",
" 1 \n",
" SA-1921617__NEU__trt_cp \n",
" 1 \n",
" SA-1925610__MCF7__trt_cp \n",
" 1 \n",
" SA-3676__NKDBA__trt_cp \n",
" 1 \n",
" SA-419083__NPC__trt_cp \n",
" 1 \n",
" SA-89068__A549__trt_cp \n",
" 1 \n",
" sarmentogenin__HA1E__trt_cp \n",
" 1 \n",
" SB-218078__HA1E__trt_cp \n",
" 1 \n",
" SB-239063__NPC__trt_cp \n",
" 1 \n",
" SB-239063__SKB__trt_cp \n",
" 1 \n",
" SB-415286__SKB__trt_cp \n",
" 1 \n",
" SB-431542__NPC__trt_cp \n",
" 1 \n",
" SB-590885__NPC__trt_cp \n",
" 1 \n",
" SCH-79797__MCF7__trt_cp \n",
" 1 \n",
" scoulerine__PHH__trt_cp \n",
" 1 \n",
" scriptaid__FIBRNPC__trt_cp \n",
" 1 \n",
" securinine__U937__trt_cp \n",
" 1 \n",
" sertaconazole__HA1E__trt_cp \n",
" 1 \n",
" SKI-II__A549__trt_cp \n",
" 1 \n",
" somatostatin__NEU__trt_cp \n",
" 1 \n",
" sorafenib__HEK293T__trt_cp \n",
" 1 \n",
" sorafenib__VCAP__trt_cp \n",
" 1 \n",
" sphingosine__PC3__trt_cp \n",
" 1 \n",
" spiramide__HEPG2__trt_cp \n",
" 1 \n",
" SR-12813__NEU__trt_cp \n",
" 1 \n",
" SR-142948__ASC__trt_cp \n",
" 1 \n",
" SR-142948__SKB__trt_cp \n",
" 1 \n",
" ST-4029010__NEU__trt_cp \n",
" 1 \n",
" ST-638__HA1E__trt_cp \n",
" 1 \n",
" staurosporine__A375__trt_cp \n",
" 1 \n",
" STK-397047__NEU__trt_cp \n",
" 1 \n",
" strophanthidin__HA1E__trt_cp \n",
" 1 \n",
" SU-1498__NPC__trt_cp \n",
" 1 \n",
" sunitinib__A549__trt_cp \n",
" 1 \n",
" SYK-inhibitor__HA1E__trt_cp \n",
" 1 \n",
" SYK-inhibitor__HS578T__trt_cp \n",
" 1 \n",
" SYK-inhibitor__NPC__trt_cp \n",
" 1 \n",
" SYK-inhibitor__SKBR3__trt_cp \n",
" 1 \n",
" tacrolimus__NEU__trt_cp \n",
" 1 \n",
" tangeritin__PHH__trt_cp \n",
" 1 \n",
" tegafur__A549__trt_cp \n",
" 1 \n",
" temozolomide__NEU__trt_cp \n",
" 1 \n",
" teniposide__NPC__trt_cp \n",
" 1 \n",
" tert-butylhydroquinone__MCF7__trt_cp \n",
" 1 \n",
" tetrabenazine__NEU__trt_cp \n",
" 1 \n",
"tetrahydrocannabinol-7-oic-acid__HA1E__trt_cp \n",
" 1 \n",
" thalidomide__HA1E__trt_cp \n",
" 1 \n",
" thapsigargin__HA1E__trt_cp \n",
" 1 \n",
" thioproperazine__VCAP__trt_cp \n",
" 1 \n",
" thiorphan__ASC__trt_cp \n",
" 1 \n",
" tolcapone__FIBRNPC__trt_cp \n",
" 1 \n",
" tolmetin__ASC__trt_cp \n",
" 1 \n",
" tolterodine__VCAP__trt_cp \n",
" 1 \n",
" toremifene__MCF7__trt_cp \n",
" 1 \n",
" torin-2__PHH__trt_cp \n",
" 1 \n",
" tranilast__PHH__trt_cp \n",
" 1 \n",
" triamcinolone__HCC515__trt_cp \n",
" 1 \n",
" tributyltin__HA1E__trt_cp \n",
" 1 \n",
" trichostatin-a__HCC515__trt_cp \n",
" 1 \n",
" trichostatin-a__NPC__trt_cp \n",
" 1 \n",
" trimetozine__HA1E__trt_cp \n",
" 1 \n",
" triphenyl-tin__HA1E__trt_cp \n",
" 1 \n",
" tubacin__PC3__trt_cp \n",
" 1 \n",
" tyrphostin-A9__HUH7__trt_cp \n",
" 1 \n",
" tyrphostin-AG-825__MCF7__trt_cp \n",
" 1 \n",
" U-0126__HEPG2__trt_cp \n",
" 1 \n",
" ubenimex__VCAP__trt_cp \n",
" 1 \n",
" vinblastine__HUH7__trt_cp \n",
" 1 \n",
" vinblastine__NEU__trt_cp \n",
" 1 \n",
" vorinostat__NEU__trt_cp \n",
" 1 \n",
" vorinostat__NPC__trt_cp \n",
" 1 \n",
" VU-0400071-3__A549__trt_cp \n",
" 1 \n",
" VU-0420363-1__VCAP__trt_cp \n",
" 1 \n",
" VU-0447127-2__MCF7__trt_cp \n",
" 1 \n",
" WAY-213613__A549__trt_cp \n",
" 1 \n",
" WH-4025__ASC__trt_cp \n",
" 1 \n",
" WHI-P154__PHH__trt_cp \n",
" 1 \n",
" WT-171__PHH__trt_cp \n",
" 1 \n",
" WYE-125132__MCF7__trt_cp \n",
" 1 \n",
" WYE-354__ASC__trt_cp \n",
" 1 \n",
" WZ-3105__NPC__trt_cp \n",
" 1 \n",
" YK-4279__HT29__trt_cp \n",
" 1 \n",
" YM-155__NEU__trt_cp \n",
" 1 \n",
" zaprinast__HA1E__trt_cp \n",
" 1 \n",
" zebularine__FIBRNPC__trt_cp \n",
" 1 \n",
" zosuquidar__PHH__trt_cp \n",
" 1 "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"#### which drug can target multiple TFs at the one experiment\n",
"multi.TFs <- sapply(drug.lists, function(x){\n",
" return(rownames(x))\n",
"})\n",
"drugs <- unlist(multi.TFs)\n",
"sort(table(drugs),decreasing = T)"
]
},
{
"cell_type": "code",
"execution_count": 34,
"id": "a4eda857-0d7a-4a50-bf1b-14d50537f4a8",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:22:32.923192Z",
"iopub.status.busy": "2021-09-23T06:22:32.919656Z",
"iopub.status.idle": "2021-09-23T06:22:33.015687Z",
"shell.execute_reply": "2021-09-23T06:22:33.014391Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 326 × 5</caption>\n",
"<thead>\n",
"\t<tr><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
"\t<tr><th scope=col><chr></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><fct></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><td>alpha-tocopherol__MCF7__trt_cp</td><td>ISL1 </td><td>-2.502400</td><td>alpha-tocopherol</td><td>MCF7 </td></tr>\n",
"\t<tr><td>alpha-tocopherol__PC3__trt_cp </td><td>ISL1 </td><td>-2.310900</td><td>alpha-tocopherol</td><td>PC3 </td></tr>\n",
"\t<tr><td>anisomycin__NEU__trt_cp </td><td>HOXC5</td><td>-2.530992</td><td>anisomycin </td><td>NEU </td></tr>\n",
"\t<tr><td>anisomycin__ASC__trt_cp </td><td>ISL1 </td><td>-2.111786</td><td>anisomycin </td><td>ASC </td></tr>\n",
"\t<tr><td>apicidin__HEPG2__trt_cp </td><td>HOXC5</td><td>-2.335700</td><td>apicidin </td><td>HEPG2 </td></tr>\n",
"\t<tr><td>apicidin__A375__trt_cp </td><td>ISL1 </td><td>-2.681550</td><td>apicidin </td><td>A375 </td></tr>\n",
"\t<tr><td>BG-1003__NEU__trt_cp </td><td>ISL1 </td><td>-2.279669</td><td>BG-1003 </td><td>NEU </td></tr>\n",
"\t<tr><td>BG-1003__NPC__trt_cp </td><td>ISL1 </td><td>-2.050464</td><td>BG-1003 </td><td>NPC </td></tr>\n",
"\t<tr><td>BG-1025__NEU__trt_cp </td><td>ISL1 </td><td>-2.330200</td><td>BG-1025 </td><td>NEU </td></tr>\n",
"\t<tr><td>BG-1025__NPC__trt_cp </td><td>ISL1 </td><td>-2.107575</td><td>BG-1025 </td><td>NPC </td></tr>\n",
"\t<tr><td>BML-257__NEU__trt_cp </td><td>ISL1 </td><td>-5.686600</td><td>BML-257 </td><td>NEU </td></tr>\n",
"\t<tr><td>BML-257__NEU__trt_cp </td><td>VENTX</td><td>-3.350300</td><td>BML-257 </td><td>NEU </td></tr>\n",
"\t<tr><td>BMY-14802__NPC__trt_cp </td><td>ISL1 </td><td>-2.252357</td><td>BMY-14802 </td><td>NPC </td></tr>\n",
"\t<tr><td>BMY-14802__PHH__trt_cp </td><td>ISL1 </td><td>-2.118578</td><td>BMY-14802 </td><td>PHH </td></tr>\n",
"\t<tr><td>BRD-A68274214__NEU__trt_cp </td><td>ISL1 </td><td>-2.049750</td><td>BRD-A68274214 </td><td>NEU </td></tr>\n",
"\t<tr><td>BRD-A68274214__VCAP__trt_cp </td><td>VENTX</td><td>-2.685372</td><td>BRD-A68274214 </td><td>VCAP </td></tr>\n",
"\t<tr><td>BRD-K02223034__A549__trt_cp </td><td>ISL1 </td><td>-2.238800</td><td>BRD-K02223034 </td><td>A549 </td></tr>\n",
"\t<tr><td>BRD-K02223034__SKB__trt_cp </td><td>ISL1 </td><td>-2.220776</td><td>BRD-K02223034 </td><td>SKB </td></tr>\n",
"\t<tr><td>BRD-K25731886__A549__trt_cp </td><td>ISL1 </td><td>-4.073600</td><td>BRD-K25731886 </td><td>A549 </td></tr>\n",
"\t<tr><td>BRD-K25731886__NEU__trt_cp </td><td>ISL1 </td><td>-2.935900</td><td>BRD-K25731886 </td><td>NEU </td></tr>\n",
"\t<tr><td>BRD-K44893543__NEU__trt_cp </td><td>HOXC5</td><td>-2.403568</td><td>BRD-K44893543 </td><td>NEU </td></tr>\n",
"\t<tr><td>BRD-K44893543__NEU__trt_cp </td><td>VENTX</td><td>-2.608974</td><td>BRD-K44893543 </td><td>NEU </td></tr>\n",
"\t<tr><td>BRD-K66884694__MCF7__trt_cp </td><td>ISL1 </td><td>-2.475050</td><td>BRD-K66884694 </td><td>MCF7 </td></tr>\n",
"\t<tr><td>BRD-K66884694__VCAP__trt_cp </td><td>ISL1 </td><td>-2.011937</td><td>BRD-K66884694 </td><td>VCAP </td></tr>\n",
"\t<tr><td>BRD-K98731749__NEU__trt_cp </td><td>ISL1 </td><td>-3.041465</td><td>BRD-K98731749 </td><td>NEU </td></tr>\n",
"\t<tr><td>BRD-K98731749__VCAP__trt_cp </td><td>VENTX</td><td>-2.255098</td><td>BRD-K98731749 </td><td>VCAP </td></tr>\n",
"\t<tr><td>butoconazole__PHH__trt_cp </td><td>ISL1 </td><td>-2.217050</td><td>butoconazole </td><td>PHH </td></tr>\n",
"\t<tr><td>butoconazole__HCC515__trt_cp </td><td>VENTX</td><td>-2.043097</td><td>butoconazole </td><td>HCC515</td></tr>\n",
"\t<tr><td>cucurbitacin-i__MCF7__trt_cp </td><td>HOXC5</td><td>-2.504937</td><td>cucurbitacin-i </td><td>MCF7 </td></tr>\n",
"\t<tr><td>cucurbitacin-i__MCF7__trt_cp </td><td>ISL1 </td><td>-2.131572</td><td>cucurbitacin-i </td><td>MCF7 </td></tr>\n",
"\t<tr><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td></tr>\n",
"\t<tr><td>SEW-05685__VCAP__trt_cp </td><td>VENTX</td><td>-2.412868</td><td>SEW-05685 </td><td>VCAP</td></tr>\n",
"\t<tr><td>SJ-172550__VCAP__trt_cp </td><td>VENTX</td><td>-2.893954</td><td>SJ-172550 </td><td>VCAP</td></tr>\n",
"\t<tr><td>sorafenib__VCAP__trt_cp </td><td>HOXC5</td><td>-2.387828</td><td>sorafenib </td><td>VCAP</td></tr>\n",
"\t<tr><td>SQ-22536__NPC__trt_cp </td><td>HOXC5</td><td>-2.024650</td><td>SQ-22536 </td><td>NPC </td></tr>\n",
"\t<tr><td>SR-12813__NEU__trt_cp </td><td>ISL1 </td><td>-2.061450</td><td>SR-12813 </td><td>NEU </td></tr>\n",
"\t<tr><td>ST-4029010__NEU__trt_cp </td><td>HOXC5</td><td>-2.160550</td><td>ST-4029010 </td><td>NEU </td></tr>\n",
"\t<tr><td>ST-638__HA1E__trt_cp </td><td>ISL1 </td><td>-2.139165</td><td>ST-638 </td><td>HA1E</td></tr>\n",
"\t<tr><td>staurosporine__A375__trt_cp </td><td>ISL1 </td><td>-3.507200</td><td>staurosporine </td><td>A375</td></tr>\n",
"\t<tr><td>STK-397047__NEU__trt_cp </td><td>ISL1 </td><td>-2.067650</td><td>STK-397047 </td><td>NEU </td></tr>\n",
"\t<tr><td>STOCK1S-03920__MCF7__trt_cp </td><td>ISL1 </td><td>-2.238906</td><td>STOCK1S-03920 </td><td>MCF7</td></tr>\n",
"\t<tr><td>temozolomide__NEU__trt_cp </td><td>ISL1 </td><td>-2.358148</td><td>temozolomide </td><td>NEU </td></tr>\n",
"\t<tr><td>teniposide__NPC__trt_cp </td><td>ISL1 </td><td>-2.629349</td><td>teniposide </td><td>NPC </td></tr>\n",
"\t<tr><td>tert-butylhydroquinone__MCF7__trt_cp</td><td>ISL1 </td><td>-3.080953</td><td>tert-butylhydroquinone</td><td>MCF7</td></tr>\n",
"\t<tr><td>toremifene__MCF7__trt_cp </td><td>HOXC5</td><td>-2.111762</td><td>toremifene </td><td>MCF7</td></tr>\n",
"\t<tr><td>torin-2__PHH__trt_cp </td><td>ISL1 </td><td>-2.098830</td><td>torin-2 </td><td>PHH </td></tr>\n",
"\t<tr><td>tranilast__PHH__trt_cp </td><td>ISL1 </td><td>-3.020363</td><td>tranilast </td><td>PHH </td></tr>\n",
"\t<tr><td>treprostinil__PHH__trt_cp </td><td>VENTX</td><td>-2.756694</td><td>treprostinil </td><td>PHH </td></tr>\n",
"\t<tr><td>tributyltin__HA1E__trt_cp </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin </td><td>HA1E</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin </td><td>HA1E</td></tr>\n",
"\t<tr><td>tubacin__VCAP__trt_cp </td><td>VENTX</td><td>-3.499640</td><td>tubacin </td><td>VCAP</td></tr>\n",
"\t<tr><td>tyrphostin-AG-825__MCF7__trt_cp </td><td>VENTX</td><td>-2.394913</td><td>tyrphostin-AG-825 </td><td>MCF7</td></tr>\n",
"\t<tr><td>ubenimex__VCAP__trt_cp </td><td>ISL1 </td><td>-2.167702</td><td>ubenimex </td><td>VCAP</td></tr>\n",
"\t<tr><td>verrucarin-a__NEU__trt_cp </td><td>HOXC5</td><td>-2.535550</td><td>verrucarin-a </td><td>NEU </td></tr>\n",
"\t<tr><td>verteporfin__VCAP__trt_cp </td><td>VENTX</td><td>-2.372383</td><td>verteporfin </td><td>VCAP</td></tr>\n",
"\t<tr><td>vinblastine__PHH__trt_cp </td><td>ISL1 </td><td>-2.215100</td><td>vinblastine </td><td>PHH </td></tr>\n",
"\t<tr><td>WYE-125132__MCF7__trt_cp </td><td>HOXC5</td><td>-2.019033</td><td>WYE-125132 </td><td>MCF7</td></tr>\n",
"\t<tr><td>WYE-354__ASC__trt_cp </td><td>HOXC5</td><td>-2.030976</td><td>WYE-354 </td><td>ASC </td></tr>\n",
"\t<tr><td>WZ-3105__NPC__trt_cp </td><td>ISL1 </td><td>-2.444200</td><td>WZ-3105 </td><td>NPC </td></tr>\n",
"\t<tr><td>YM-155__NPC__trt_cp </td><td>ISL1 </td><td>-2.259500</td><td>YM-155 </td><td>NPC </td></tr>\n",
"\t<tr><td>zoxazolamine__PHH__trt_cp </td><td>VENTX</td><td>-2.148100</td><td>zoxazolamine </td><td>PHH </td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 326 × 5\n",
"\\begin{tabular}{lllll}\n",
" Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
" <chr> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
"\\hline\n",
"\t alpha-tocopherol\\_\\_MCF7\\_\\_trt\\_cp & ISL1 & -2.502400 & alpha-tocopherol & MCF7 \\\\\n",
"\t alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & ISL1 & -2.310900 & alpha-tocopherol & PC3 \\\\\n",
"\t anisomycin\\_\\_NEU\\_\\_trt\\_cp & HOXC5 & -2.530992 & anisomycin & NEU \\\\\n",
"\t anisomycin\\_\\_ASC\\_\\_trt\\_cp & ISL1 & -2.111786 & anisomycin & ASC \\\\\n",
"\t apicidin\\_\\_HEPG2\\_\\_trt\\_cp & HOXC5 & -2.335700 & apicidin & HEPG2 \\\\\n",
"\t apicidin\\_\\_A375\\_\\_trt\\_cp & ISL1 & -2.681550 & apicidin & A375 \\\\\n",
"\t BG-1003\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.279669 & BG-1003 & NEU \\\\\n",
"\t BG-1003\\_\\_NPC\\_\\_trt\\_cp & ISL1 & -2.050464 & BG-1003 & NPC \\\\\n",
"\t BG-1025\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.330200 & BG-1025 & NEU \\\\\n",
"\t BG-1025\\_\\_NPC\\_\\_trt\\_cp & ISL1 & -2.107575 & BG-1025 & NPC \\\\\n",
"\t BML-257\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -5.686600 & BML-257 & NEU \\\\\n",
"\t BML-257\\_\\_NEU\\_\\_trt\\_cp & VENTX & -3.350300 & BML-257 & NEU \\\\\n",
"\t BMY-14802\\_\\_NPC\\_\\_trt\\_cp & ISL1 & -2.252357 & BMY-14802 & NPC \\\\\n",
"\t BMY-14802\\_\\_PHH\\_\\_trt\\_cp & ISL1 & -2.118578 & BMY-14802 & PHH \\\\\n",
"\t BRD-A68274214\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.049750 & BRD-A68274214 & NEU \\\\\n",
"\t BRD-A68274214\\_\\_VCAP\\_\\_trt\\_cp & VENTX & -2.685372 & BRD-A68274214 & VCAP \\\\\n",
"\t BRD-K02223034\\_\\_A549\\_\\_trt\\_cp & ISL1 & -2.238800 & BRD-K02223034 & A549 \\\\\n",
"\t BRD-K02223034\\_\\_SKB\\_\\_trt\\_cp & ISL1 & -2.220776 & BRD-K02223034 & SKB \\\\\n",
"\t BRD-K25731886\\_\\_A549\\_\\_trt\\_cp & ISL1 & -4.073600 & BRD-K25731886 & A549 \\\\\n",
"\t BRD-K25731886\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.935900 & BRD-K25731886 & NEU \\\\\n",
"\t BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & HOXC5 & -2.403568 & BRD-K44893543 & NEU \\\\\n",
"\t BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & VENTX & -2.608974 & BRD-K44893543 & NEU \\\\\n",
"\t BRD-K66884694\\_\\_MCF7\\_\\_trt\\_cp & ISL1 & -2.475050 & BRD-K66884694 & MCF7 \\\\\n",
"\t BRD-K66884694\\_\\_VCAP\\_\\_trt\\_cp & ISL1 & -2.011937 & BRD-K66884694 & VCAP \\\\\n",
"\t BRD-K98731749\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -3.041465 & BRD-K98731749 & NEU \\\\\n",
"\t BRD-K98731749\\_\\_VCAP\\_\\_trt\\_cp & VENTX & -2.255098 & BRD-K98731749 & VCAP \\\\\n",
"\t butoconazole\\_\\_PHH\\_\\_trt\\_cp & ISL1 & -2.217050 & butoconazole & PHH \\\\\n",
"\t butoconazole\\_\\_HCC515\\_\\_trt\\_cp & VENTX & -2.043097 & butoconazole & HCC515\\\\\n",
"\t cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & HOXC5 & -2.504937 & cucurbitacin-i & MCF7 \\\\\n",
"\t cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & ISL1 & -2.131572 & cucurbitacin-i & MCF7 \\\\\n",
"\t ⋮ & ⋮ & ⋮ & ⋮ & ⋮\\\\\n",
"\t SEW-05685\\_\\_VCAP\\_\\_trt\\_cp & VENTX & -2.412868 & SEW-05685 & VCAP\\\\\n",
"\t SJ-172550\\_\\_VCAP\\_\\_trt\\_cp & VENTX & -2.893954 & SJ-172550 & VCAP\\\\\n",
"\t sorafenib\\_\\_VCAP\\_\\_trt\\_cp & HOXC5 & -2.387828 & sorafenib & VCAP\\\\\n",
"\t SQ-22536\\_\\_NPC\\_\\_trt\\_cp & HOXC5 & -2.024650 & SQ-22536 & NPC \\\\\n",
"\t SR-12813\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.061450 & SR-12813 & NEU \\\\\n",
"\t ST-4029010\\_\\_NEU\\_\\_trt\\_cp & HOXC5 & -2.160550 & ST-4029010 & NEU \\\\\n",
"\t ST-638\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.139165 & ST-638 & HA1E\\\\\n",
"\t staurosporine\\_\\_A375\\_\\_trt\\_cp & ISL1 & -3.507200 & staurosporine & A375\\\\\n",
"\t STK-397047\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.067650 & STK-397047 & NEU \\\\\n",
"\t STOCK1S-03920\\_\\_MCF7\\_\\_trt\\_cp & ISL1 & -2.238906 & STOCK1S-03920 & MCF7\\\\\n",
"\t temozolomide\\_\\_NEU\\_\\_trt\\_cp & ISL1 & -2.358148 & temozolomide & NEU \\\\\n",
"\t teniposide\\_\\_NPC\\_\\_trt\\_cp & ISL1 & -2.629349 & teniposide & NPC \\\\\n",
"\t tert-butylhydroquinone\\_\\_MCF7\\_\\_trt\\_cp & ISL1 & -3.080953 & tert-butylhydroquinone & MCF7\\\\\n",
"\t toremifene\\_\\_MCF7\\_\\_trt\\_cp & HOXC5 & -2.111762 & toremifene & MCF7\\\\\n",
"\t torin-2\\_\\_PHH\\_\\_trt\\_cp & ISL1 & -2.098830 & torin-2 & PHH \\\\\n",
"\t tranilast\\_\\_PHH\\_\\_trt\\_cp & ISL1 & -3.020363 & tranilast & PHH \\\\\n",
"\t treprostinil\\_\\_PHH\\_\\_trt\\_cp & VENTX & -2.756694 & treprostinil & PHH \\\\\n",
"\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -3.094550 & tributyltin & HA1E\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.005953 & triphenyl-tin & HA1E\\\\\n",
"\t tubacin\\_\\_VCAP\\_\\_trt\\_cp & VENTX & -3.499640 & tubacin & VCAP\\\\\n",
"\t tyrphostin-AG-825\\_\\_MCF7\\_\\_trt\\_cp & VENTX & -2.394913 & tyrphostin-AG-825 & MCF7\\\\\n",
"\t ubenimex\\_\\_VCAP\\_\\_trt\\_cp & ISL1 & -2.167702 & ubenimex & VCAP\\\\\n",
"\t verrucarin-a\\_\\_NEU\\_\\_trt\\_cp & HOXC5 & -2.535550 & verrucarin-a & NEU \\\\\n",
"\t verteporfin\\_\\_VCAP\\_\\_trt\\_cp & VENTX & -2.372383 & verteporfin & VCAP\\\\\n",
"\t vinblastine\\_\\_PHH\\_\\_trt\\_cp & ISL1 & -2.215100 & vinblastine & PHH \\\\\n",
"\t WYE-125132\\_\\_MCF7\\_\\_trt\\_cp & HOXC5 & -2.019033 & WYE-125132 & MCF7\\\\\n",
"\t WYE-354\\_\\_ASC\\_\\_trt\\_cp & HOXC5 & -2.030976 & WYE-354 & ASC \\\\\n",
"\t WZ-3105\\_\\_NPC\\_\\_trt\\_cp & ISL1 & -2.444200 & WZ-3105 & NPC \\\\\n",
"\t YM-155\\_\\_NPC\\_\\_trt\\_cp & ISL1 & -2.259500 & YM-155 & NPC \\\\\n",
"\t zoxazolamine\\_\\_PHH\\_\\_trt\\_cp & VENTX & -2.148100 & zoxazolamine & PHH \\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 326 × 5\n",
"\n",
"| Drug <chr> | TF <chr> | ZSCORE <dbl> | Drug.name <fct> | cellLine <chr> |\n",
"|---|---|---|---|---|\n",
"| alpha-tocopherol__MCF7__trt_cp | ISL1 | -2.502400 | alpha-tocopherol | MCF7 |\n",
"| alpha-tocopherol__PC3__trt_cp | ISL1 | -2.310900 | alpha-tocopherol | PC3 |\n",
"| anisomycin__NEU__trt_cp | HOXC5 | -2.530992 | anisomycin | NEU |\n",
"| anisomycin__ASC__trt_cp | ISL1 | -2.111786 | anisomycin | ASC |\n",
"| apicidin__HEPG2__trt_cp | HOXC5 | -2.335700 | apicidin | HEPG2 |\n",
"| apicidin__A375__trt_cp | ISL1 | -2.681550 | apicidin | A375 |\n",
"| BG-1003__NEU__trt_cp | ISL1 | -2.279669 | BG-1003 | NEU |\n",
"| BG-1003__NPC__trt_cp | ISL1 | -2.050464 | BG-1003 | NPC |\n",
"| BG-1025__NEU__trt_cp | ISL1 | -2.330200 | BG-1025 | NEU |\n",
"| BG-1025__NPC__trt_cp | ISL1 | -2.107575 | BG-1025 | NPC |\n",
"| BML-257__NEU__trt_cp | ISL1 | -5.686600 | BML-257 | NEU |\n",
"| BML-257__NEU__trt_cp | VENTX | -3.350300 | BML-257 | NEU |\n",
"| BMY-14802__NPC__trt_cp | ISL1 | -2.252357 | BMY-14802 | NPC |\n",
"| BMY-14802__PHH__trt_cp | ISL1 | -2.118578 | BMY-14802 | PHH |\n",
"| BRD-A68274214__NEU__trt_cp | ISL1 | -2.049750 | BRD-A68274214 | NEU |\n",
"| BRD-A68274214__VCAP__trt_cp | VENTX | -2.685372 | BRD-A68274214 | VCAP |\n",
"| BRD-K02223034__A549__trt_cp | ISL1 | -2.238800 | BRD-K02223034 | A549 |\n",
"| BRD-K02223034__SKB__trt_cp | ISL1 | -2.220776 | BRD-K02223034 | SKB |\n",
"| BRD-K25731886__A549__trt_cp | ISL1 | -4.073600 | BRD-K25731886 | A549 |\n",
"| BRD-K25731886__NEU__trt_cp | ISL1 | -2.935900 | BRD-K25731886 | NEU |\n",
"| BRD-K44893543__NEU__trt_cp | HOXC5 | -2.403568 | BRD-K44893543 | NEU |\n",
"| BRD-K44893543__NEU__trt_cp | VENTX | -2.608974 | BRD-K44893543 | NEU |\n",
"| BRD-K66884694__MCF7__trt_cp | ISL1 | -2.475050 | BRD-K66884694 | MCF7 |\n",
"| BRD-K66884694__VCAP__trt_cp | ISL1 | -2.011937 | BRD-K66884694 | VCAP |\n",
"| BRD-K98731749__NEU__trt_cp | ISL1 | -3.041465 | BRD-K98731749 | NEU |\n",
"| BRD-K98731749__VCAP__trt_cp | VENTX | -2.255098 | BRD-K98731749 | VCAP |\n",
"| butoconazole__PHH__trt_cp | ISL1 | -2.217050 | butoconazole | PHH |\n",
"| butoconazole__HCC515__trt_cp | VENTX | -2.043097 | butoconazole | HCC515 |\n",
"| cucurbitacin-i__MCF7__trt_cp | HOXC5 | -2.504937 | cucurbitacin-i | MCF7 |\n",
"| cucurbitacin-i__MCF7__trt_cp | ISL1 | -2.131572 | cucurbitacin-i | MCF7 |\n",
"| ⋮ | ⋮ | ⋮ | ⋮ | ⋮ |\n",
"| SEW-05685__VCAP__trt_cp | VENTX | -2.412868 | SEW-05685 | VCAP |\n",
"| SJ-172550__VCAP__trt_cp | VENTX | -2.893954 | SJ-172550 | VCAP |\n",
"| sorafenib__VCAP__trt_cp | HOXC5 | -2.387828 | sorafenib | VCAP |\n",
"| SQ-22536__NPC__trt_cp | HOXC5 | -2.024650 | SQ-22536 | NPC |\n",
"| SR-12813__NEU__trt_cp | ISL1 | -2.061450 | SR-12813 | NEU |\n",
"| ST-4029010__NEU__trt_cp | HOXC5 | -2.160550 | ST-4029010 | NEU |\n",
"| ST-638__HA1E__trt_cp | ISL1 | -2.139165 | ST-638 | HA1E |\n",
"| staurosporine__A375__trt_cp | ISL1 | -3.507200 | staurosporine | A375 |\n",
"| STK-397047__NEU__trt_cp | ISL1 | -2.067650 | STK-397047 | NEU |\n",
"| STOCK1S-03920__MCF7__trt_cp | ISL1 | -2.238906 | STOCK1S-03920 | MCF7 |\n",
"| temozolomide__NEU__trt_cp | ISL1 | -2.358148 | temozolomide | NEU |\n",
"| teniposide__NPC__trt_cp | ISL1 | -2.629349 | teniposide | NPC |\n",
"| tert-butylhydroquinone__MCF7__trt_cp | ISL1 | -3.080953 | tert-butylhydroquinone | MCF7 |\n",
"| toremifene__MCF7__trt_cp | HOXC5 | -2.111762 | toremifene | MCF7 |\n",
"| torin-2__PHH__trt_cp | ISL1 | -2.098830 | torin-2 | PHH |\n",
"| tranilast__PHH__trt_cp | ISL1 | -3.020363 | tranilast | PHH |\n",
"| treprostinil__PHH__trt_cp | VENTX | -2.756694 | treprostinil | PHH |\n",
"| tributyltin__HA1E__trt_cp | ISL1 | -3.094550 | tributyltin | HA1E |\n",
"| triphenyl-tin__HA1E__trt_cp | ISL1 | -2.005953 | triphenyl-tin | HA1E |\n",
"| tubacin__VCAP__trt_cp | VENTX | -3.499640 | tubacin | VCAP |\n",
"| tyrphostin-AG-825__MCF7__trt_cp | VENTX | -2.394913 | tyrphostin-AG-825 | MCF7 |\n",
"| ubenimex__VCAP__trt_cp | ISL1 | -2.167702 | ubenimex | VCAP |\n",
"| verrucarin-a__NEU__trt_cp | HOXC5 | -2.535550 | verrucarin-a | NEU |\n",
"| verteporfin__VCAP__trt_cp | VENTX | -2.372383 | verteporfin | VCAP |\n",
"| vinblastine__PHH__trt_cp | ISL1 | -2.215100 | vinblastine | PHH |\n",
"| WYE-125132__MCF7__trt_cp | HOXC5 | -2.019033 | WYE-125132 | MCF7 |\n",
"| WYE-354__ASC__trt_cp | HOXC5 | -2.030976 | WYE-354 | ASC |\n",
"| WZ-3105__NPC__trt_cp | ISL1 | -2.444200 | WZ-3105 | NPC |\n",
"| YM-155__NPC__trt_cp | ISL1 | -2.259500 | YM-155 | NPC |\n",
"| zoxazolamine__PHH__trt_cp | VENTX | -2.148100 | zoxazolamine | PHH |\n",
"\n"
],
"text/plain": [
" Drug TF ZSCORE Drug.name \n",
"1 alpha-tocopherol__MCF7__trt_cp ISL1 -2.502400 alpha-tocopherol \n",
"2 alpha-tocopherol__PC3__trt_cp ISL1 -2.310900 alpha-tocopherol \n",
"3 anisomycin__NEU__trt_cp HOXC5 -2.530992 anisomycin \n",
"4 anisomycin__ASC__trt_cp ISL1 -2.111786 anisomycin \n",
"5 apicidin__HEPG2__trt_cp HOXC5 -2.335700 apicidin \n",
"6 apicidin__A375__trt_cp ISL1 -2.681550 apicidin \n",
"7 BG-1003__NEU__trt_cp ISL1 -2.279669 BG-1003 \n",
"8 BG-1003__NPC__trt_cp ISL1 -2.050464 BG-1003 \n",
"9 BG-1025__NEU__trt_cp ISL1 -2.330200 BG-1025 \n",
"10 BG-1025__NPC__trt_cp ISL1 -2.107575 BG-1025 \n",
"11 BML-257__NEU__trt_cp ISL1 -5.686600 BML-257 \n",
"12 BML-257__NEU__trt_cp VENTX -3.350300 BML-257 \n",
"13 BMY-14802__NPC__trt_cp ISL1 -2.252357 BMY-14802 \n",
"14 BMY-14802__PHH__trt_cp ISL1 -2.118578 BMY-14802 \n",
"15 BRD-A68274214__NEU__trt_cp ISL1 -2.049750 BRD-A68274214 \n",
"16 BRD-A68274214__VCAP__trt_cp VENTX -2.685372 BRD-A68274214 \n",
"17 BRD-K02223034__A549__trt_cp ISL1 -2.238800 BRD-K02223034 \n",
"18 BRD-K02223034__SKB__trt_cp ISL1 -2.220776 BRD-K02223034 \n",
"19 BRD-K25731886__A549__trt_cp ISL1 -4.073600 BRD-K25731886 \n",
"20 BRD-K25731886__NEU__trt_cp ISL1 -2.935900 BRD-K25731886 \n",
"21 BRD-K44893543__NEU__trt_cp HOXC5 -2.403568 BRD-K44893543 \n",
"22 BRD-K44893543__NEU__trt_cp VENTX -2.608974 BRD-K44893543 \n",
"23 BRD-K66884694__MCF7__trt_cp ISL1 -2.475050 BRD-K66884694 \n",
"24 BRD-K66884694__VCAP__trt_cp ISL1 -2.011937 BRD-K66884694 \n",
"25 BRD-K98731749__NEU__trt_cp ISL1 -3.041465 BRD-K98731749 \n",
"26 BRD-K98731749__VCAP__trt_cp VENTX -2.255098 BRD-K98731749 \n",
"27 butoconazole__PHH__trt_cp ISL1 -2.217050 butoconazole \n",
"28 butoconazole__HCC515__trt_cp VENTX -2.043097 butoconazole \n",
"29 cucurbitacin-i__MCF7__trt_cp HOXC5 -2.504937 cucurbitacin-i \n",
"30 cucurbitacin-i__MCF7__trt_cp ISL1 -2.131572 cucurbitacin-i \n",
"⋮ ⋮ ⋮ ⋮ ⋮ \n",
"297 SEW-05685__VCAP__trt_cp VENTX -2.412868 SEW-05685 \n",
"298 SJ-172550__VCAP__trt_cp VENTX -2.893954 SJ-172550 \n",
"299 sorafenib__VCAP__trt_cp HOXC5 -2.387828 sorafenib \n",
"300 SQ-22536__NPC__trt_cp HOXC5 -2.024650 SQ-22536 \n",
"301 SR-12813__NEU__trt_cp ISL1 -2.061450 SR-12813 \n",
"302 ST-4029010__NEU__trt_cp HOXC5 -2.160550 ST-4029010 \n",
"303 ST-638__HA1E__trt_cp ISL1 -2.139165 ST-638 \n",
"304 staurosporine__A375__trt_cp ISL1 -3.507200 staurosporine \n",
"305 STK-397047__NEU__trt_cp ISL1 -2.067650 STK-397047 \n",
"306 STOCK1S-03920__MCF7__trt_cp ISL1 -2.238906 STOCK1S-03920 \n",
"307 temozolomide__NEU__trt_cp ISL1 -2.358148 temozolomide \n",
"308 teniposide__NPC__trt_cp ISL1 -2.629349 teniposide \n",
"309 tert-butylhydroquinone__MCF7__trt_cp ISL1 -3.080953 tert-butylhydroquinone\n",
"310 toremifene__MCF7__trt_cp HOXC5 -2.111762 toremifene \n",
"311 torin-2__PHH__trt_cp ISL1 -2.098830 torin-2 \n",
"312 tranilast__PHH__trt_cp ISL1 -3.020363 tranilast \n",
"313 treprostinil__PHH__trt_cp VENTX -2.756694 treprostinil \n",
"314 tributyltin__HA1E__trt_cp ISL1 -3.094550 tributyltin \n",
"315 triphenyl-tin__HA1E__trt_cp ISL1 -2.005953 triphenyl-tin \n",
"316 tubacin__VCAP__trt_cp VENTX -3.499640 tubacin \n",
"317 tyrphostin-AG-825__MCF7__trt_cp VENTX -2.394913 tyrphostin-AG-825 \n",
"318 ubenimex__VCAP__trt_cp ISL1 -2.167702 ubenimex \n",
"319 verrucarin-a__NEU__trt_cp HOXC5 -2.535550 verrucarin-a \n",
"320 verteporfin__VCAP__trt_cp VENTX -2.372383 verteporfin \n",
"321 vinblastine__PHH__trt_cp ISL1 -2.215100 vinblastine \n",
"322 WYE-125132__MCF7__trt_cp HOXC5 -2.019033 WYE-125132 \n",
"323 WYE-354__ASC__trt_cp HOXC5 -2.030976 WYE-354 \n",
"324 WZ-3105__NPC__trt_cp ISL1 -2.444200 WZ-3105 \n",
"325 YM-155__NPC__trt_cp ISL1 -2.259500 YM-155 \n",
"326 zoxazolamine__PHH__trt_cp VENTX -2.148100 zoxazolamine \n",
" cellLine\n",
"1 MCF7 \n",
"2 PC3 \n",
"3 NEU \n",
"4 ASC \n",
"5 HEPG2 \n",
"6 A375 \n",
"7 NEU \n",
"8 NPC \n",
"9 NEU \n",
"10 NPC \n",
"11 NEU \n",
"12 NEU \n",
"13 NPC \n",
"14 PHH \n",
"15 NEU \n",
"16 VCAP \n",
"17 A549 \n",
"18 SKB \n",
"19 A549 \n",
"20 NEU \n",
"21 NEU \n",
"22 NEU \n",
"23 MCF7 \n",
"24 VCAP \n",
"25 NEU \n",
"26 VCAP \n",
"27 PHH \n",
"28 HCC515 \n",
"29 MCF7 \n",
"30 MCF7 \n",
"⋮ ⋮ \n",
"297 VCAP \n",
"298 VCAP \n",
"299 VCAP \n",
"300 NPC \n",
"301 NEU \n",
"302 NEU \n",
"303 HA1E \n",
"304 A375 \n",
"305 NEU \n",
"306 MCF7 \n",
"307 NEU \n",
"308 NPC \n",
"309 MCF7 \n",
"310 MCF7 \n",
"311 PHH \n",
"312 PHH \n",
"313 PHH \n",
"314 HA1E \n",
"315 HA1E \n",
"316 VCAP \n",
"317 MCF7 \n",
"318 VCAP \n",
"319 NEU \n",
"320 VCAP \n",
"321 PHH \n",
"322 MCF7 \n",
"323 ASC \n",
"324 NPC \n",
"325 NPC \n",
"326 PHH "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"####output \n",
"library (plyr)\n",
"drug.result <- ldply (drug.lists, data.frame)\n",
"drug.result <- drug.result[,c(2,1,3)]\n",
"colnames(drug.result) <- c(\"Drug\", \"TF\", \"ZSCORE\")\n",
"library(writexl)\n",
"drug.result$Drug.name <- gsub(\"__.*\", \"\", drug.result$Drug)\n",
"drug.result$cellLine <- gsub(\"__trt_cp\", \"\", drug.result$Drug)\n",
"drug.result$cellLine <- gsub(\".*__\", \"\", drug.result$cellLine)\n",
"drug.idx <- sort(table(drug.result$Drug.name),decreasing = T)\n",
"drug.result$Drug.name <- factor(drug.result$Drug.name, levels = names(drug.idx))\n",
"drug.result <- arrange(drug.result, Drug.name, TF, Drug)\n",
"write_xlsx(drug.result, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.negative.drug.result.xlsx\")\n",
"drug.result"
]
},
{
"cell_type": "markdown",
"id": "d84ea99d-1cdd-492b-a2c7-8f7f86f2ac1b",
"metadata": {},
"source": [
"##### 查看Lincs中的药物信息和细胞系信息"
]
},
{
"cell_type": "code",
"execution_count": 35,
"id": "a23c2274-8430-4715-9f07-385ba9e74767",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:22:38.342470Z",
"iopub.status.busy": "2021-09-23T06:22:38.338912Z",
"iopub.status.idle": "2021-09-23T06:22:50.668557Z",
"shell.execute_reply": "2021-09-23T06:22:50.667164Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 6 × 35</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>bead_batch</th><th scope=col>nearest_dose</th><th scope=col>pert_dose</th><th scope=col>pert_dose_unit</th><th scope=col>pert_idose</th><th scope=col>pert_itime</th><th scope=col>pert_time</th><th scope=col>pert_time_unit</th><th scope=col>cell_mfc_name</th><th scope=col>pert_mfc_id</th><th scope=col>⋯</th><th scope=col>sig_id</th><th scope=col>pert_type</th><th scope=col>cell_iname</th><th scope=col>det_wells</th><th scope=col>det_plates</th><th scope=col>distil_ids</th><th scope=col>build_name</th><th scope=col>project_code</th><th scope=col>cmap_name</th><th scope=col>is_ncs_exemplar</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><dbl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col>⋯</th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><lgl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><int></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>1</th><td>b17</td><td> NA</td><td>100.0</td><td>ug/ml</td><td>100 ug/ml</td><td>336 h</td><td>336</td><td>h</td><td>N8 </td><td>BRD-U44432129</td><td>⋯</td><td>MET001_N8_XH:BRD-U44432129:100:336 </td><td>trt_cp</td><td>NAMEC8</td><td>H05|H06|H07|H08</td><td>MET001_N8_XH_X1_B17 </td><td>MET001_N8_XH_X1_B17:H05|MET001_N8_XH_X1_B17:H06|MET001_N8_XH_X1_B17:H07|MET001_N8_XH_X1_B17:H08</td><td>NA</td><td>MET</td><td>BRD-U44432129</td><td>0</td></tr>\n",
"\t<tr><th scope=row>2</th><td>b15</td><td>10.0</td><td> 10.0</td><td>uM </td><td>10 uM </td><td>3 h </td><td> 3</td><td>h</td><td>A549 </td><td>BRD-K81418486</td><td>⋯</td><td>ABY001_A549_XH:BRD-K81418486:10:3 </td><td>trt_cp</td><td>A549 </td><td>L04|L08|L12 </td><td>ABY001_A549_XH_X1_B15 </td><td>ABY001_A549_XH_X1_B15:L04|ABY001_A549_XH_X1_B15:L08|ABY001_A549_XH_X1_B15:L12 </td><td>NA</td><td>ABY</td><td>vorinostat </td><td>0</td></tr>\n",
"\t<tr><th scope=row>3</th><td>b15</td><td> 2.5</td><td> 2.5</td><td>uM </td><td>2.5 uM </td><td>24 h </td><td> 24</td><td>h</td><td>HT29 </td><td>BRD-K70511574</td><td>⋯</td><td>ABY001_HT29_XH:BRD-K70511574:2.5:24</td><td>trt_cp</td><td>HT29 </td><td>E18|E22 </td><td>ABY001_HT29_XH_X1_B15 </td><td>ABY001_HT29_XH_X1_B15:E18|ABY001_HT29_XH_X1_B15:E22 </td><td>NA</td><td>ABY</td><td>HMN-214 </td><td>0</td></tr>\n",
"\t<tr><th scope=row>4</th><td>b18</td><td>10.0</td><td> 10.0</td><td>uM </td><td>10 uM </td><td>3 h </td><td> 3</td><td>h</td><td>HME1 </td><td>BRD-K81418486</td><td>⋯</td><td>LTC002_HME1_3H:BRD-K81418486:10 </td><td>trt_cp</td><td>HME1 </td><td>F19 </td><td>LTC002_HME1_3H_X1_B18 </td><td>LTC002_HME1_3H_X1_B18:F19 </td><td>NA</td><td>LTC</td><td>vorinostat </td><td>0</td></tr>\n",
"\t<tr><th scope=row>5</th><td>b15</td><td>10.0</td><td> 10.0</td><td>uM </td><td>10 uM </td><td>3 h </td><td> 3</td><td>h</td><td>H1975</td><td>BRD-A61304759</td><td>⋯</td><td>ABY001_H1975_XH:BRD-A61304759:10:3 </td><td>trt_cp</td><td>H1975 </td><td>P01|P05|P09 </td><td>ABY001_H1975_XH_X1_B15</td><td>ABY001_H1975_XH_X1_B15:P01|ABY001_H1975_XH_X1_B15:P05|ABY001_H1975_XH_X1_B15:P09 </td><td>NA</td><td>ABY</td><td>tanespimycin </td><td>0</td></tr>\n",
"\t<tr><th scope=row>6</th><td>b15</td><td>10.0</td><td> 10.0</td><td>uM </td><td>10 uM </td><td>24 h </td><td> 24</td><td>h</td><td>H1975</td><td>BRD-K85606544</td><td>⋯</td><td>ABY001_H1975_XH:BRD-K85606544:10:24</td><td>trt_cp</td><td>H1975 </td><td>A15|A19|A23 </td><td>ABY001_H1975_XH_X1_B15</td><td>ABY001_H1975_XH_X1_B15:A15|ABY001_H1975_XH_X1_B15:A19|ABY001_H1975_XH_X1_B15:A23 </td><td>NA</td><td>ABY</td><td>neratinib </td><td>0</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 6 × 35\n",
"\\begin{tabular}{r|lllllllllllllllllllll}\n",
" & bead\\_batch & nearest\\_dose & pert\\_dose & pert\\_dose\\_unit & pert\\_idose & pert\\_itime & pert\\_time & pert\\_time\\_unit & cell\\_mfc\\_name & pert\\_mfc\\_id & ⋯ & sig\\_id & pert\\_type & cell\\_iname & det\\_wells & det\\_plates & distil\\_ids & build\\_name & project\\_code & cmap\\_name & is\\_ncs\\_exemplar\\\\\n",
" & <chr> & <dbl> & <dbl> & <chr> & <chr> & <chr> & <dbl> & <chr> & <chr> & <chr> & ⋯ & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <lgl> & <chr> & <chr> & <int>\\\\\n",
"\\hline\n",
"\t1 & b17 & NA & 100.0 & ug/ml & 100 ug/ml & 336 h & 336 & h & N8 & BRD-U44432129 & ⋯ & MET001\\_N8\\_XH:BRD-U44432129:100:336 & trt\\_cp & NAMEC8 & H05\\textbar{}H06\\textbar{}H07\\textbar{}H08 & MET001\\_N8\\_XH\\_X1\\_B17 & MET001\\_N8\\_XH\\_X1\\_B17:H05\\textbar{}MET001\\_N8\\_XH\\_X1\\_B17:H06\\textbar{}MET001\\_N8\\_XH\\_X1\\_B17:H07\\textbar{}MET001\\_N8\\_XH\\_X1\\_B17:H08 & NA & MET & BRD-U44432129 & 0\\\\\n",
"\t2 & b15 & 10.0 & 10.0 & uM & 10 uM & 3 h & 3 & h & A549 & BRD-K81418486 & ⋯ & ABY001\\_A549\\_XH:BRD-K81418486:10:3 & trt\\_cp & A549 & L04\\textbar{}L08\\textbar{}L12 & ABY001\\_A549\\_XH\\_X1\\_B15 & ABY001\\_A549\\_XH\\_X1\\_B15:L04\\textbar{}ABY001\\_A549\\_XH\\_X1\\_B15:L08\\textbar{}ABY001\\_A549\\_XH\\_X1\\_B15:L12 & NA & ABY & vorinostat & 0\\\\\n",
"\t3 & b15 & 2.5 & 2.5 & uM & 2.5 uM & 24 h & 24 & h & HT29 & BRD-K70511574 & ⋯ & ABY001\\_HT29\\_XH:BRD-K70511574:2.5:24 & trt\\_cp & HT29 & E18\\textbar{}E22 & ABY001\\_HT29\\_XH\\_X1\\_B15 & ABY001\\_HT29\\_XH\\_X1\\_B15:E18\\textbar{}ABY001\\_HT29\\_XH\\_X1\\_B15:E22 & NA & ABY & HMN-214 & 0\\\\\n",
"\t4 & b18 & 10.0 & 10.0 & uM & 10 uM & 3 h & 3 & h & HME1 & BRD-K81418486 & ⋯ & LTC002\\_HME1\\_3H:BRD-K81418486:10 & trt\\_cp & HME1 & F19 & LTC002\\_HME1\\_3H\\_X1\\_B18 & LTC002\\_HME1\\_3H\\_X1\\_B18:F19 & NA & LTC & vorinostat & 0\\\\\n",
"\t5 & b15 & 10.0 & 10.0 & uM & 10 uM & 3 h & 3 & h & H1975 & BRD-A61304759 & ⋯ & ABY001\\_H1975\\_XH:BRD-A61304759:10:3 & trt\\_cp & H1975 & P01\\textbar{}P05\\textbar{}P09 & ABY001\\_H1975\\_XH\\_X1\\_B15 & ABY001\\_H1975\\_XH\\_X1\\_B15:P01\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:P05\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:P09 & NA & ABY & tanespimycin & 0\\\\\n",
"\t6 & b15 & 10.0 & 10.0 & uM & 10 uM & 24 h & 24 & h & H1975 & BRD-K85606544 & ⋯ & ABY001\\_H1975\\_XH:BRD-K85606544:10:24 & trt\\_cp & H1975 & A15\\textbar{}A19\\textbar{}A23 & ABY001\\_H1975\\_XH\\_X1\\_B15 & ABY001\\_H1975\\_XH\\_X1\\_B15:A15\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:A19\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:A23 & NA & ABY & neratinib & 0\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 6 × 35\n",
"\n",
"| <!--/--> | bead_batch <chr> | nearest_dose <dbl> | pert_dose <dbl> | pert_dose_unit <chr> | pert_idose <chr> | pert_itime <chr> | pert_time <dbl> | pert_time_unit <chr> | cell_mfc_name <chr> | pert_mfc_id <chr> | ⋯ ⋯ | sig_id <chr> | pert_type <chr> | cell_iname <chr> | det_wells <chr> | det_plates <chr> | distil_ids <chr> | build_name <lgl> | project_code <chr> | cmap_name <chr> | is_ncs_exemplar <int> |\n",
"|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
"| 1 | b17 | NA | 100.0 | ug/ml | 100 ug/ml | 336 h | 336 | h | N8 | BRD-U44432129 | ⋯ | MET001_N8_XH:BRD-U44432129:100:336 | trt_cp | NAMEC8 | H05|H06|H07|H08 | MET001_N8_XH_X1_B17 | MET001_N8_XH_X1_B17:H05|MET001_N8_XH_X1_B17:H06|MET001_N8_XH_X1_B17:H07|MET001_N8_XH_X1_B17:H08 | NA | MET | BRD-U44432129 | 0 |\n",
"| 2 | b15 | 10.0 | 10.0 | uM | 10 uM | 3 h | 3 | h | A549 | BRD-K81418486 | ⋯ | ABY001_A549_XH:BRD-K81418486:10:3 | trt_cp | A549 | L04|L08|L12 | ABY001_A549_XH_X1_B15 | ABY001_A549_XH_X1_B15:L04|ABY001_A549_XH_X1_B15:L08|ABY001_A549_XH_X1_B15:L12 | NA | ABY | vorinostat | 0 |\n",
"| 3 | b15 | 2.5 | 2.5 | uM | 2.5 uM | 24 h | 24 | h | HT29 | BRD-K70511574 | ⋯ | ABY001_HT29_XH:BRD-K70511574:2.5:24 | trt_cp | HT29 | E18|E22 | ABY001_HT29_XH_X1_B15 | ABY001_HT29_XH_X1_B15:E18|ABY001_HT29_XH_X1_B15:E22 | NA | ABY | HMN-214 | 0 |\n",
"| 4 | b18 | 10.0 | 10.0 | uM | 10 uM | 3 h | 3 | h | HME1 | BRD-K81418486 | ⋯ | LTC002_HME1_3H:BRD-K81418486:10 | trt_cp | HME1 | F19 | LTC002_HME1_3H_X1_B18 | LTC002_HME1_3H_X1_B18:F19 | NA | LTC | vorinostat | 0 |\n",
"| 5 | b15 | 10.0 | 10.0 | uM | 10 uM | 3 h | 3 | h | H1975 | BRD-A61304759 | ⋯ | ABY001_H1975_XH:BRD-A61304759:10:3 | trt_cp | H1975 | P01|P05|P09 | ABY001_H1975_XH_X1_B15 | ABY001_H1975_XH_X1_B15:P01|ABY001_H1975_XH_X1_B15:P05|ABY001_H1975_XH_X1_B15:P09 | NA | ABY | tanespimycin | 0 |\n",
"| 6 | b15 | 10.0 | 10.0 | uM | 10 uM | 24 h | 24 | h | H1975 | BRD-K85606544 | ⋯ | ABY001_H1975_XH:BRD-K85606544:10:24 | trt_cp | H1975 | A15|A19|A23 | ABY001_H1975_XH_X1_B15 | ABY001_H1975_XH_X1_B15:A15|ABY001_H1975_XH_X1_B15:A19|ABY001_H1975_XH_X1_B15:A23 | NA | ABY | neratinib | 0 |\n",
"\n"
],
"text/plain": [
" bead_batch nearest_dose pert_dose pert_dose_unit pert_idose pert_itime\n",
"1 b17 NA 100.0 ug/ml 100 ug/ml 336 h \n",
"2 b15 10.0 10.0 uM 10 uM 3 h \n",
"3 b15 2.5 2.5 uM 2.5 uM 24 h \n",
"4 b18 10.0 10.0 uM 10 uM 3 h \n",
"5 b15 10.0 10.0 uM 10 uM 3 h \n",
"6 b15 10.0 10.0 uM 10 uM 24 h \n",
" pert_time pert_time_unit cell_mfc_name pert_mfc_id ⋯\n",
"1 336 h N8 BRD-U44432129 ⋯\n",
"2 3 h A549 BRD-K81418486 ⋯\n",
"3 24 h HT29 BRD-K70511574 ⋯\n",
"4 3 h HME1 BRD-K81418486 ⋯\n",
"5 3 h H1975 BRD-A61304759 ⋯\n",
"6 24 h H1975 BRD-K85606544 ⋯\n",
" sig_id pert_type cell_iname det_wells \n",
"1 MET001_N8_XH:BRD-U44432129:100:336 trt_cp NAMEC8 H05|H06|H07|H08\n",
"2 ABY001_A549_XH:BRD-K81418486:10:3 trt_cp A549 L04|L08|L12 \n",
"3 ABY001_HT29_XH:BRD-K70511574:2.5:24 trt_cp HT29 E18|E22 \n",
"4 LTC002_HME1_3H:BRD-K81418486:10 trt_cp HME1 F19 \n",
"5 ABY001_H1975_XH:BRD-A61304759:10:3 trt_cp H1975 P01|P05|P09 \n",
"6 ABY001_H1975_XH:BRD-K85606544:10:24 trt_cp H1975 A15|A19|A23 \n",
" det_plates \n",
"1 MET001_N8_XH_X1_B17 \n",
"2 ABY001_A549_XH_X1_B15 \n",
"3 ABY001_HT29_XH_X1_B15 \n",
"4 LTC002_HME1_3H_X1_B18 \n",
"5 ABY001_H1975_XH_X1_B15\n",
"6 ABY001_H1975_XH_X1_B15\n",
" distil_ids \n",
"1 MET001_N8_XH_X1_B17:H05|MET001_N8_XH_X1_B17:H06|MET001_N8_XH_X1_B17:H07|MET001_N8_XH_X1_B17:H08\n",
"2 ABY001_A549_XH_X1_B15:L04|ABY001_A549_XH_X1_B15:L08|ABY001_A549_XH_X1_B15:L12 \n",
"3 ABY001_HT29_XH_X1_B15:E18|ABY001_HT29_XH_X1_B15:E22 \n",
"4 LTC002_HME1_3H_X1_B18:F19 \n",
"5 ABY001_H1975_XH_X1_B15:P01|ABY001_H1975_XH_X1_B15:P05|ABY001_H1975_XH_X1_B15:P09 \n",
"6 ABY001_H1975_XH_X1_B15:A15|ABY001_H1975_XH_X1_B15:A19|ABY001_H1975_XH_X1_B15:A23 \n",
" build_name project_code cmap_name is_ncs_exemplar\n",
"1 NA MET BRD-U44432129 0 \n",
"2 NA ABY vorinostat 0 \n",
"3 NA ABY HMN-214 0 \n",
"4 NA LTC vorinostat 0 \n",
"5 NA ABY tanespimycin 0 \n",
"6 NA ABY neratinib 0 "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"####drug information\n",
"siginfo_beta <- read.table(file = \"siginfo_beta.txt\", header = T, stringsAsFactors = F, sep = \"\\t\")\n",
"head(siginfo_beta)"
]
},
{
"cell_type": "code",
"execution_count": 36,
"id": "32fd238a-fb78-4b15-bdfa-e401de3ff7eb",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:22:55.046444Z",
"iopub.status.busy": "2021-09-23T06:22:55.041761Z",
"iopub.status.idle": "2021-09-23T06:22:55.068934Z",
"shell.execute_reply": "2021-09-23T06:22:55.067514Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<style>\n",
".list-inline {list-style: none; margin:0; padding: 0}\n",
".list-inline>li {display: inline-block}\n",
".list-inline>li:not(:last-child)::after {content: \"\\00b7\"; padding: 0 .5ex}\n",
"</style>\n",
"<ol class=list-inline><li>'1HAE'</li><li>'AALE'</li><li>'AG06263_2'</li><li>'AG06840_A'</li><li>'AG078N1_1'</li><li>'C42'</li><li>'CD34'</li><li>'HAP1'</li><li>'HEK293T'</li><li>'HIMG001'</li><li>'HIMG002'</li><li>'HME'</li><li>'HMELZ'</li><li>'HPTEC'</li><li>'HS27A'</li><li>'HUES3'</li><li>'HUH751'</li><li>'HUVEC'</li><li>'IPS-15-2'</li><li>'IPS-3'</li><li>'IPS-ND34732'</li><li>'LHSAR'</li><li>'MCH58'</li><li>'MCLF0067SZ'</li><li>'MCLF015CN'</li><li>'MCLF022CN'</li><li>'MCLF027CN'</li><li>'MCLF033SZ'</li><li>'MCLF035SZ'</li><li>'MCLF037SZ'</li><li>'MCLF040SZ'</li><li>'MCLF051CN'</li><li>'MCLF054CN'</li><li>'MCLF056CN'</li><li>'MCLF076SZ'</li><li>'MCLF100SZ'</li><li>'MCLF117SZ'</li><li>'MCLF123SZ'</li><li>'MCLF126CN'</li><li>'MCLF130CN'</li><li>'MCLF135CN'</li><li>'MCLF137CN'</li><li>'MCLF141SZ'</li><li>'MCLF162SZ'</li><li>'MICROGLIA-PSEN1'</li><li>'MNEU'</li><li>'NAMEC8'</li><li>'ND34732_7'</li><li>'NKDBA'</li><li>'P1A82'</li><li>'P2X2B2'</li><li>'SKB'</li><li>'WA09'</li><li>'XC.500'</li><li>'XC.L10'</li><li>'XC.L100'</li><li>'XC.P026'</li><li>'XC.P031'</li><li>'XC.P033'</li><li>'XC.P091'</li><li>'XC.P092'</li><li>'XC.P901'</li><li>'XC.P904'</li><li>'XC.P905'</li><li>'XC.P906'</li><li>'XC.P907'</li><li>'XC.P908'</li><li>'XC.P909'</li><li>'XC.P910'</li><li>'XC.P911'</li><li>'XC.P912'</li><li>'XC.P914'</li><li>'XC.P915'</li><li>'XC.P922'</li><li>'XC.P930'</li><li>'XC.P931'</li><li>'XC.P932'</li><li>'XC.P933'</li><li>'XC.P934'</li><li>'XC.P935'</li><li>'XC.P936'</li><li>'XC.R10'</li><li>'HME1'</li><li>'BJAB'</li><li>'HBL1'</li><li>'OCILY10'</li><li>'TMD8'</li><li>'TC32'</li><li>'H1299'</li><li>'H1975'</li><li>'HCC515'</li><li>'SALE'</li><li>'SHSY5Y'</li><li>'22RV1'</li><li>'HEC1A'</li><li>'NL20'</li><li>'PHH'</li><li>'HA1E'</li><li>'HEK293'</li><li>'HEKTE'</li><li>'NEU'</li><li>'NPC'</li><li>'ASC'</li><li>'U266B1'</li><li>'HL60'</li><li>'K562'</li><li>'TF1'</li><li>'THP1'</li><li>'MINO'</li><li>'U937'</li><li>'A673'</li><li>'SKES1'</li><li>'U2OS'</li><li>'A549'</li><li>'HCC827'</li><li>'NCIH1437'</li><li>'NCIH1563'</li><li>'NCIH1573'</li><li>'NCIH1694'</li><li>'NCIH1781'</li><li>'NCIH1836'</li><li>'NCIH1975'</li><li>'NCIH2073'</li><li>'NCIH2110'</li><li>'NCIH2172'</li><li>'NCIH596'</li><li>'NCIH838'</li><li>'NCIH841'</li><li>'SKLU1'</li><li>'A375'</li><li>'SH4'</li><li>'SKMEL1'</li><li>'SKMEL28'</li><li>'SKMEL3'</li><li>'SKMEL5'</li><li>'LN229'</li><li>'DLD1'</li><li>'HCT116'</li><li>'HT29'</li><li>'LOVO'</li><li>'NCIH508'</li><li>'NCIH716'</li><li>'RKO'</li><li>'SW480'</li><li>'SW620'</li><li>'SW948'</li><li>'HEPG2'</li><li>'BT20'</li><li>'BT474'</li><li>'HS578T'</li><li>'MCF10A'</li><li>'MCF7'</li><li>'MDAMB231'</li><li>'MDAMB468'</li><li>'SKBR3'</li><li>'T47D'</li><li>'ZR751'</li><li>'G401'</li><li>'SKNSH'</li><li>'5637'</li><li>'J82'</li><li>'AGS'</li><li>'ES2'</li><li>'HELA'</li><li>'DU145'</li><li>'PC3'</li><li>'RWPE1'</li><li>'VCAP'</li><li>'A204'</li><li>'AN3CA'</li><li>'TOV112D'</li><li>'WI38'</li><li>'JURKAT'</li><li>'NALM6'</li><li>'PL21'</li><li>'OCILY19'</li><li>'SUDHL4'</li><li>'WSUDLCL2'</li><li>'BEN'</li><li>'DV90'</li><li>'HCC15'</li><li>'HCC44'</li><li>'IGR37'</li><li>'MELHO'</li><li>'CL34'</li><li>'BC3C'</li><li>'CAL29'</li><li>'VMCUB1'</li><li>'EFO27'</li><li>'LNCAP'</li><li>'YAPC'</li><li>'MFE319'</li><li>'OC314'</li><li>'OC316'</li><li>'HFL1'</li><li>'IMR90'</li><li>'HCC1588'</li><li>'HCC95'</li><li>'SNU1040'</li><li>'SNU407'</li><li>'SNUC4'</li><li>'SNUC5'</li><li>'CORL23'</li><li>'GP2D'</li><li>'HT115'</li><li>'MDST8'</li><li>'COV434'</li><li>'COV644'</li><li>'OAW28'</li><li>'OV7'</li><li>'BICR6'</li><li>'KMS34'</li><li>'NOMO1'</li><li>'SKM1'</li><li>'U251MG'</li><li>'YH13'</li><li>'HUH7'</li><li>'JHH5'</li><li>'JHH7'</li><li>'IM95'</li><li>'MKN45'</li><li>'OVTOKO'</li><li>'RMGI'</li><li>'RMUGS'</li><li>'TYKNU'</li><li>'HEC108'</li><li>'HEC151'</li><li>'HEC251'</li><li>'HEC265'</li><li>'SNGM'</li><li>'SKL'</li><li>'T3M10'</li><li>'CJM'</li><li>'GI1'</li><li>'CW2'</li><li>'RCC10RGB'</li><li>'OVK18'</li><li>'JHUEM2'</li><li>'OVCAR8'</li><li>'OCILY3'</li></ol>\n"
],
"text/latex": [
"\\begin{enumerate*}\n",
"\\item '1HAE'\n",
"\\item 'AALE'\n",
"\\item 'AG06263\\_2'\n",
"\\item 'AG06840\\_A'\n",
"\\item 'AG078N1\\_1'\n",
"\\item 'C42'\n",
"\\item 'CD34'\n",
"\\item 'HAP1'\n",
"\\item 'HEK293T'\n",
"\\item 'HIMG001'\n",
"\\item 'HIMG002'\n",
"\\item 'HME'\n",
"\\item 'HMELZ'\n",
"\\item 'HPTEC'\n",
"\\item 'HS27A'\n",
"\\item 'HUES3'\n",
"\\item 'HUH751'\n",
"\\item 'HUVEC'\n",
"\\item 'IPS-15-2'\n",
"\\item 'IPS-3'\n",
"\\item 'IPS-ND34732'\n",
"\\item 'LHSAR'\n",
"\\item 'MCH58'\n",
"\\item 'MCLF0067SZ'\n",
"\\item 'MCLF015CN'\n",
"\\item 'MCLF022CN'\n",
"\\item 'MCLF027CN'\n",
"\\item 'MCLF033SZ'\n",
"\\item 'MCLF035SZ'\n",
"\\item 'MCLF037SZ'\n",
"\\item 'MCLF040SZ'\n",
"\\item 'MCLF051CN'\n",
"\\item 'MCLF054CN'\n",
"\\item 'MCLF056CN'\n",
"\\item 'MCLF076SZ'\n",
"\\item 'MCLF100SZ'\n",
"\\item 'MCLF117SZ'\n",
"\\item 'MCLF123SZ'\n",
"\\item 'MCLF126CN'\n",
"\\item 'MCLF130CN'\n",
"\\item 'MCLF135CN'\n",
"\\item 'MCLF137CN'\n",
"\\item 'MCLF141SZ'\n",
"\\item 'MCLF162SZ'\n",
"\\item 'MICROGLIA-PSEN1'\n",
"\\item 'MNEU'\n",
"\\item 'NAMEC8'\n",
"\\item 'ND34732\\_7'\n",
"\\item 'NKDBA'\n",
"\\item 'P1A82'\n",
"\\item 'P2X2B2'\n",
"\\item 'SKB'\n",
"\\item 'WA09'\n",
"\\item 'XC.500'\n",
"\\item 'XC.L10'\n",
"\\item 'XC.L100'\n",
"\\item 'XC.P026'\n",
"\\item 'XC.P031'\n",
"\\item 'XC.P033'\n",
"\\item 'XC.P091'\n",
"\\item 'XC.P092'\n",
"\\item 'XC.P901'\n",
"\\item 'XC.P904'\n",
"\\item 'XC.P905'\n",
"\\item 'XC.P906'\n",
"\\item 'XC.P907'\n",
"\\item 'XC.P908'\n",
"\\item 'XC.P909'\n",
"\\item 'XC.P910'\n",
"\\item 'XC.P911'\n",
"\\item 'XC.P912'\n",
"\\item 'XC.P914'\n",
"\\item 'XC.P915'\n",
"\\item 'XC.P922'\n",
"\\item 'XC.P930'\n",
"\\item 'XC.P931'\n",
"\\item 'XC.P932'\n",
"\\item 'XC.P933'\n",
"\\item 'XC.P934'\n",
"\\item 'XC.P935'\n",
"\\item 'XC.P936'\n",
"\\item 'XC.R10'\n",
"\\item 'HME1'\n",
"\\item 'BJAB'\n",
"\\item 'HBL1'\n",
"\\item 'OCILY10'\n",
"\\item 'TMD8'\n",
"\\item 'TC32'\n",
"\\item 'H1299'\n",
"\\item 'H1975'\n",
"\\item 'HCC515'\n",
"\\item 'SALE'\n",
"\\item 'SHSY5Y'\n",
"\\item '22RV1'\n",
"\\item 'HEC1A'\n",
"\\item 'NL20'\n",
"\\item 'PHH'\n",
"\\item 'HA1E'\n",
"\\item 'HEK293'\n",
"\\item 'HEKTE'\n",
"\\item 'NEU'\n",
"\\item 'NPC'\n",
"\\item 'ASC'\n",
"\\item 'U266B1'\n",
"\\item 'HL60'\n",
"\\item 'K562'\n",
"\\item 'TF1'\n",
"\\item 'THP1'\n",
"\\item 'MINO'\n",
"\\item 'U937'\n",
"\\item 'A673'\n",
"\\item 'SKES1'\n",
"\\item 'U2OS'\n",
"\\item 'A549'\n",
"\\item 'HCC827'\n",
"\\item 'NCIH1437'\n",
"\\item 'NCIH1563'\n",
"\\item 'NCIH1573'\n",
"\\item 'NCIH1694'\n",
"\\item 'NCIH1781'\n",
"\\item 'NCIH1836'\n",
"\\item 'NCIH1975'\n",
"\\item 'NCIH2073'\n",
"\\item 'NCIH2110'\n",
"\\item 'NCIH2172'\n",
"\\item 'NCIH596'\n",
"\\item 'NCIH838'\n",
"\\item 'NCIH841'\n",
"\\item 'SKLU1'\n",
"\\item 'A375'\n",
"\\item 'SH4'\n",
"\\item 'SKMEL1'\n",
"\\item 'SKMEL28'\n",
"\\item 'SKMEL3'\n",
"\\item 'SKMEL5'\n",
"\\item 'LN229'\n",
"\\item 'DLD1'\n",
"\\item 'HCT116'\n",
"\\item 'HT29'\n",
"\\item 'LOVO'\n",
"\\item 'NCIH508'\n",
"\\item 'NCIH716'\n",
"\\item 'RKO'\n",
"\\item 'SW480'\n",
"\\item 'SW620'\n",
"\\item 'SW948'\n",
"\\item 'HEPG2'\n",
"\\item 'BT20'\n",
"\\item 'BT474'\n",
"\\item 'HS578T'\n",
"\\item 'MCF10A'\n",
"\\item 'MCF7'\n",
"\\item 'MDAMB231'\n",
"\\item 'MDAMB468'\n",
"\\item 'SKBR3'\n",
"\\item 'T47D'\n",
"\\item 'ZR751'\n",
"\\item 'G401'\n",
"\\item 'SKNSH'\n",
"\\item '5637'\n",
"\\item 'J82'\n",
"\\item 'AGS'\n",
"\\item 'ES2'\n",
"\\item 'HELA'\n",
"\\item 'DU145'\n",
"\\item 'PC3'\n",
"\\item 'RWPE1'\n",
"\\item 'VCAP'\n",
"\\item 'A204'\n",
"\\item 'AN3CA'\n",
"\\item 'TOV112D'\n",
"\\item 'WI38'\n",
"\\item 'JURKAT'\n",
"\\item 'NALM6'\n",
"\\item 'PL21'\n",
"\\item 'OCILY19'\n",
"\\item 'SUDHL4'\n",
"\\item 'WSUDLCL2'\n",
"\\item 'BEN'\n",
"\\item 'DV90'\n",
"\\item 'HCC15'\n",
"\\item 'HCC44'\n",
"\\item 'IGR37'\n",
"\\item 'MELHO'\n",
"\\item 'CL34'\n",
"\\item 'BC3C'\n",
"\\item 'CAL29'\n",
"\\item 'VMCUB1'\n",
"\\item 'EFO27'\n",
"\\item 'LNCAP'\n",
"\\item 'YAPC'\n",
"\\item 'MFE319'\n",
"\\item 'OC314'\n",
"\\item 'OC316'\n",
"\\item 'HFL1'\n",
"\\item 'IMR90'\n",
"\\item 'HCC1588'\n",
"\\item 'HCC95'\n",
"\\item 'SNU1040'\n",
"\\item 'SNU407'\n",
"\\item 'SNUC4'\n",
"\\item 'SNUC5'\n",
"\\item 'CORL23'\n",
"\\item 'GP2D'\n",
"\\item 'HT115'\n",
"\\item 'MDST8'\n",
"\\item 'COV434'\n",
"\\item 'COV644'\n",
"\\item 'OAW28'\n",
"\\item 'OV7'\n",
"\\item 'BICR6'\n",
"\\item 'KMS34'\n",
"\\item 'NOMO1'\n",
"\\item 'SKM1'\n",
"\\item 'U251MG'\n",
"\\item 'YH13'\n",
"\\item 'HUH7'\n",
"\\item 'JHH5'\n",
"\\item 'JHH7'\n",
"\\item 'IM95'\n",
"\\item 'MKN45'\n",
"\\item 'OVTOKO'\n",
"\\item 'RMGI'\n",
"\\item 'RMUGS'\n",
"\\item 'TYKNU'\n",
"\\item 'HEC108'\n",
"\\item 'HEC151'\n",
"\\item 'HEC251'\n",
"\\item 'HEC265'\n",
"\\item 'SNGM'\n",
"\\item 'SKL'\n",
"\\item 'T3M10'\n",
"\\item 'CJM'\n",
"\\item 'GI1'\n",
"\\item 'CW2'\n",
"\\item 'RCC10RGB'\n",
"\\item 'OVK18'\n",
"\\item 'JHUEM2'\n",
"\\item 'OVCAR8'\n",
"\\item 'OCILY3'\n",
"\\end{enumerate*}\n"
],
"text/markdown": [
"1. '1HAE'\n",
"2. 'AALE'\n",
"3. 'AG06263_2'\n",
"4. 'AG06840_A'\n",
"5. 'AG078N1_1'\n",
"6. 'C42'\n",
"7. 'CD34'\n",
"8. 'HAP1'\n",
"9. 'HEK293T'\n",
"10. 'HIMG001'\n",
"11. 'HIMG002'\n",
"12. 'HME'\n",
"13. 'HMELZ'\n",
"14. 'HPTEC'\n",
"15. 'HS27A'\n",
"16. 'HUES3'\n",
"17. 'HUH751'\n",
"18. 'HUVEC'\n",
"19. 'IPS-15-2'\n",
"20. 'IPS-3'\n",
"21. 'IPS-ND34732'\n",
"22. 'LHSAR'\n",
"23. 'MCH58'\n",
"24. 'MCLF0067SZ'\n",
"25. 'MCLF015CN'\n",
"26. 'MCLF022CN'\n",
"27. 'MCLF027CN'\n",
"28. 'MCLF033SZ'\n",
"29. 'MCLF035SZ'\n",
"30. 'MCLF037SZ'\n",
"31. 'MCLF040SZ'\n",
"32. 'MCLF051CN'\n",
"33. 'MCLF054CN'\n",
"34. 'MCLF056CN'\n",
"35. 'MCLF076SZ'\n",
"36. 'MCLF100SZ'\n",
"37. 'MCLF117SZ'\n",
"38. 'MCLF123SZ'\n",
"39. 'MCLF126CN'\n",
"40. 'MCLF130CN'\n",
"41. 'MCLF135CN'\n",
"42. 'MCLF137CN'\n",
"43. 'MCLF141SZ'\n",
"44. 'MCLF162SZ'\n",
"45. 'MICROGLIA-PSEN1'\n",
"46. 'MNEU'\n",
"47. 'NAMEC8'\n",
"48. 'ND34732_7'\n",
"49. 'NKDBA'\n",
"50. 'P1A82'\n",
"51. 'P2X2B2'\n",
"52. 'SKB'\n",
"53. 'WA09'\n",
"54. 'XC.500'\n",
"55. 'XC.L10'\n",
"56. 'XC.L100'\n",
"57. 'XC.P026'\n",
"58. 'XC.P031'\n",
"59. 'XC.P033'\n",
"60. 'XC.P091'\n",
"61. 'XC.P092'\n",
"62. 'XC.P901'\n",
"63. 'XC.P904'\n",
"64. 'XC.P905'\n",
"65. 'XC.P906'\n",
"66. 'XC.P907'\n",
"67. 'XC.P908'\n",
"68. 'XC.P909'\n",
"69. 'XC.P910'\n",
"70. 'XC.P911'\n",
"71. 'XC.P912'\n",
"72. 'XC.P914'\n",
"73. 'XC.P915'\n",
"74. 'XC.P922'\n",
"75. 'XC.P930'\n",
"76. 'XC.P931'\n",
"77. 'XC.P932'\n",
"78. 'XC.P933'\n",
"79. 'XC.P934'\n",
"80. 'XC.P935'\n",
"81. 'XC.P936'\n",
"82. 'XC.R10'\n",
"83. 'HME1'\n",
"84. 'BJAB'\n",
"85. 'HBL1'\n",
"86. 'OCILY10'\n",
"87. 'TMD8'\n",
"88. 'TC32'\n",
"89. 'H1299'\n",
"90. 'H1975'\n",
"91. 'HCC515'\n",
"92. 'SALE'\n",
"93. 'SHSY5Y'\n",
"94. '22RV1'\n",
"95. 'HEC1A'\n",
"96. 'NL20'\n",
"97. 'PHH'\n",
"98. 'HA1E'\n",
"99. 'HEK293'\n",
"100. 'HEKTE'\n",
"101. 'NEU'\n",
"102. 'NPC'\n",
"103. 'ASC'\n",
"104. 'U266B1'\n",
"105. 'HL60'\n",
"106. 'K562'\n",
"107. 'TF1'\n",
"108. 'THP1'\n",
"109. 'MINO'\n",
"110. 'U937'\n",
"111. 'A673'\n",
"112. 'SKES1'\n",
"113. 'U2OS'\n",
"114. 'A549'\n",
"115. 'HCC827'\n",
"116. 'NCIH1437'\n",
"117. 'NCIH1563'\n",
"118. 'NCIH1573'\n",
"119. 'NCIH1694'\n",
"120. 'NCIH1781'\n",
"121. 'NCIH1836'\n",
"122. 'NCIH1975'\n",
"123. 'NCIH2073'\n",
"124. 'NCIH2110'\n",
"125. 'NCIH2172'\n",
"126. 'NCIH596'\n",
"127. 'NCIH838'\n",
"128. 'NCIH841'\n",
"129. 'SKLU1'\n",
"130. 'A375'\n",
"131. 'SH4'\n",
"132. 'SKMEL1'\n",
"133. 'SKMEL28'\n",
"134. 'SKMEL3'\n",
"135. 'SKMEL5'\n",
"136. 'LN229'\n",
"137. 'DLD1'\n",
"138. 'HCT116'\n",
"139. 'HT29'\n",
"140. 'LOVO'\n",
"141. 'NCIH508'\n",
"142. 'NCIH716'\n",
"143. 'RKO'\n",
"144. 'SW480'\n",
"145. 'SW620'\n",
"146. 'SW948'\n",
"147. 'HEPG2'\n",
"148. 'BT20'\n",
"149. 'BT474'\n",
"150. 'HS578T'\n",
"151. 'MCF10A'\n",
"152. 'MCF7'\n",
"153. 'MDAMB231'\n",
"154. 'MDAMB468'\n",
"155. 'SKBR3'\n",
"156. 'T47D'\n",
"157. 'ZR751'\n",
"158. 'G401'\n",
"159. 'SKNSH'\n",
"160. '5637'\n",
"161. 'J82'\n",
"162. 'AGS'\n",
"163. 'ES2'\n",
"164. 'HELA'\n",
"165. 'DU145'\n",
"166. 'PC3'\n",
"167. 'RWPE1'\n",
"168. 'VCAP'\n",
"169. 'A204'\n",
"170. 'AN3CA'\n",
"171. 'TOV112D'\n",
"172. 'WI38'\n",
"173. 'JURKAT'\n",
"174. 'NALM6'\n",
"175. 'PL21'\n",
"176. 'OCILY19'\n",
"177. 'SUDHL4'\n",
"178. 'WSUDLCL2'\n",
"179. 'BEN'\n",
"180. 'DV90'\n",
"181. 'HCC15'\n",
"182. 'HCC44'\n",
"183. 'IGR37'\n",
"184. 'MELHO'\n",
"185. 'CL34'\n",
"186. 'BC3C'\n",
"187. 'CAL29'\n",
"188. 'VMCUB1'\n",
"189. 'EFO27'\n",
"190. 'LNCAP'\n",
"191. 'YAPC'\n",
"192. 'MFE319'\n",
"193. 'OC314'\n",
"194. 'OC316'\n",
"195. 'HFL1'\n",
"196. 'IMR90'\n",
"197. 'HCC1588'\n",
"198. 'HCC95'\n",
"199. 'SNU1040'\n",
"200. 'SNU407'\n",
"201. 'SNUC4'\n",
"202. 'SNUC5'\n",
"203. 'CORL23'\n",
"204. 'GP2D'\n",
"205. 'HT115'\n",
"206. 'MDST8'\n",
"207. 'COV434'\n",
"208. 'COV644'\n",
"209. 'OAW28'\n",
"210. 'OV7'\n",
"211. 'BICR6'\n",
"212. 'KMS34'\n",
"213. 'NOMO1'\n",
"214. 'SKM1'\n",
"215. 'U251MG'\n",
"216. 'YH13'\n",
"217. 'HUH7'\n",
"218. 'JHH5'\n",
"219. 'JHH7'\n",
"220. 'IM95'\n",
"221. 'MKN45'\n",
"222. 'OVTOKO'\n",
"223. 'RMGI'\n",
"224. 'RMUGS'\n",
"225. 'TYKNU'\n",
"226. 'HEC108'\n",
"227. 'HEC151'\n",
"228. 'HEC251'\n",
"229. 'HEC265'\n",
"230. 'SNGM'\n",
"231. 'SKL'\n",
"232. 'T3M10'\n",
"233. 'CJM'\n",
"234. 'GI1'\n",
"235. 'CW2'\n",
"236. 'RCC10RGB'\n",
"237. 'OVK18'\n",
"238. 'JHUEM2'\n",
"239. 'OVCAR8'\n",
"240. 'OCILY3'\n",
"\n",
"\n"
],
"text/plain": [
" [1] \"1HAE\" \"AALE\" \"AG06263_2\" \"AG06840_A\" \n",
" [5] \"AG078N1_1\" \"C42\" \"CD34\" \"HAP1\" \n",
" [9] \"HEK293T\" \"HIMG001\" \"HIMG002\" \"HME\" \n",
" [13] \"HMELZ\" \"HPTEC\" \"HS27A\" \"HUES3\" \n",
" [17] \"HUH751\" \"HUVEC\" \"IPS-15-2\" \"IPS-3\" \n",
" [21] \"IPS-ND34732\" \"LHSAR\" \"MCH58\" \"MCLF0067SZ\" \n",
" [25] \"MCLF015CN\" \"MCLF022CN\" \"MCLF027CN\" \"MCLF033SZ\" \n",
" [29] \"MCLF035SZ\" \"MCLF037SZ\" \"MCLF040SZ\" \"MCLF051CN\" \n",
" [33] \"MCLF054CN\" \"MCLF056CN\" \"MCLF076SZ\" \"MCLF100SZ\" \n",
" [37] \"MCLF117SZ\" \"MCLF123SZ\" \"MCLF126CN\" \"MCLF130CN\" \n",
" [41] \"MCLF135CN\" \"MCLF137CN\" \"MCLF141SZ\" \"MCLF162SZ\" \n",
" [45] \"MICROGLIA-PSEN1\" \"MNEU\" \"NAMEC8\" \"ND34732_7\" \n",
" [49] \"NKDBA\" \"P1A82\" \"P2X2B2\" \"SKB\" \n",
" [53] \"WA09\" \"XC.500\" \"XC.L10\" \"XC.L100\" \n",
" [57] \"XC.P026\" \"XC.P031\" \"XC.P033\" \"XC.P091\" \n",
" [61] \"XC.P092\" \"XC.P901\" \"XC.P904\" \"XC.P905\" \n",
" [65] \"XC.P906\" \"XC.P907\" \"XC.P908\" \"XC.P909\" \n",
" [69] \"XC.P910\" \"XC.P911\" \"XC.P912\" \"XC.P914\" \n",
" [73] \"XC.P915\" \"XC.P922\" \"XC.P930\" \"XC.P931\" \n",
" [77] \"XC.P932\" \"XC.P933\" \"XC.P934\" \"XC.P935\" \n",
" [81] \"XC.P936\" \"XC.R10\" \"HME1\" \"BJAB\" \n",
" [85] \"HBL1\" \"OCILY10\" \"TMD8\" \"TC32\" \n",
" [89] \"H1299\" \"H1975\" \"HCC515\" \"SALE\" \n",
" [93] \"SHSY5Y\" \"22RV1\" \"HEC1A\" \"NL20\" \n",
" [97] \"PHH\" \"HA1E\" \"HEK293\" \"HEKTE\" \n",
"[101] \"NEU\" \"NPC\" \"ASC\" \"U266B1\" \n",
"[105] \"HL60\" \"K562\" \"TF1\" \"THP1\" \n",
"[109] \"MINO\" \"U937\" \"A673\" \"SKES1\" \n",
"[113] \"U2OS\" \"A549\" \"HCC827\" \"NCIH1437\" \n",
"[117] \"NCIH1563\" \"NCIH1573\" \"NCIH1694\" \"NCIH1781\" \n",
"[121] \"NCIH1836\" \"NCIH1975\" \"NCIH2073\" \"NCIH2110\" \n",
"[125] \"NCIH2172\" \"NCIH596\" \"NCIH838\" \"NCIH841\" \n",
"[129] \"SKLU1\" \"A375\" \"SH4\" \"SKMEL1\" \n",
"[133] \"SKMEL28\" \"SKMEL3\" \"SKMEL5\" \"LN229\" \n",
"[137] \"DLD1\" \"HCT116\" \"HT29\" \"LOVO\" \n",
"[141] \"NCIH508\" \"NCIH716\" \"RKO\" \"SW480\" \n",
"[145] \"SW620\" \"SW948\" \"HEPG2\" \"BT20\" \n",
"[149] \"BT474\" \"HS578T\" \"MCF10A\" \"MCF7\" \n",
"[153] \"MDAMB231\" \"MDAMB468\" \"SKBR3\" \"T47D\" \n",
"[157] \"ZR751\" \"G401\" \"SKNSH\" \"5637\" \n",
"[161] \"J82\" \"AGS\" \"ES2\" \"HELA\" \n",
"[165] \"DU145\" \"PC3\" \"RWPE1\" \"VCAP\" \n",
"[169] \"A204\" \"AN3CA\" \"TOV112D\" \"WI38\" \n",
"[173] \"JURKAT\" \"NALM6\" \"PL21\" \"OCILY19\" \n",
"[177] \"SUDHL4\" \"WSUDLCL2\" \"BEN\" \"DV90\" \n",
"[181] \"HCC15\" \"HCC44\" \"IGR37\" \"MELHO\" \n",
"[185] \"CL34\" \"BC3C\" \"CAL29\" \"VMCUB1\" \n",
"[189] \"EFO27\" \"LNCAP\" \"YAPC\" \"MFE319\" \n",
"[193] \"OC314\" \"OC316\" \"HFL1\" \"IMR90\" \n",
"[197] \"HCC1588\" \"HCC95\" \"SNU1040\" \"SNU407\" \n",
"[201] \"SNUC4\" \"SNUC5\" \"CORL23\" \"GP2D\" \n",
"[205] \"HT115\" \"MDST8\" \"COV434\" \"COV644\" \n",
"[209] \"OAW28\" \"OV7\" \"BICR6\" \"KMS34\" \n",
"[213] \"NOMO1\" \"SKM1\" \"U251MG\" \"YH13\" \n",
"[217] \"HUH7\" \"JHH5\" \"JHH7\" \"IM95\" \n",
"[221] \"MKN45\" \"OVTOKO\" \"RMGI\" \"RMUGS\" \n",
"[225] \"TYKNU\" \"HEC108\" \"HEC151\" \"HEC251\" \n",
"[229] \"HEC265\" \"SNGM\" \"SKL\" \"T3M10\" \n",
"[233] \"CJM\" \"GI1\" \"CW2\" \"RCC10RGB\" \n",
"[237] \"OVK18\" \"JHUEM2\" \"OVCAR8\" \"OCILY3\" "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"cellinfo_beta <- read.table(file = \"cellinfo_beta.modify.txt\", header = T, stringsAsFactors = F, sep = \"\\t\", comment.char = \"!\")\n",
"cellinfo_beta$cell_iname"
]
},
{
"cell_type": "code",
"execution_count": 37,
"id": "16a3c5f4-a7e8-4e7e-bdc1-60c838a2daf5",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:22:57.611433Z",
"iopub.status.busy": "2021-09-23T06:22:57.607919Z",
"iopub.status.idle": "2021-09-23T06:22:57.657961Z",
"shell.execute_reply": "2021-09-23T06:22:57.656660Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 5 × 20</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>cell_iname</th><th scope=col>cellosaurus_id</th><th scope=col>donor_age</th><th scope=col>donor_age_death</th><th scope=col>donor_disease_age_onset</th><th scope=col>doubling_time</th><th scope=col>growth_medium</th><th scope=col>provider_catalog_id</th><th scope=col>feature_id</th><th scope=col>cell_type</th><th scope=col>donor_ethnicity</th><th scope=col>donor_sex</th><th scope=col>donor_tumor_phase</th><th scope=col>cell_lineage</th><th scope=col>primary_disease</th><th scope=col>subtype</th><th scope=col>provider_name</th><th scope=col>growth_pattern</th><th scope=col>ccle_name</th><th scope=col>cell_alias</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><lgl></th><th scope=col><lgl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>98</th><td>HA1E </td><td> </td><td> </td><td>NA</td><td>NA</td><td>60 </td><td>MEM-ALPHA (Invitrogen A1049001) supplemented with 10% v/v fetal bovine serum (Sigma F4135) and 1% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016) </td><td> </td><td> </td><td>normal</td><td>Unknown </td><td>Unknown</td><td>Unknown</td><td>kidney </td><td>normal kidney sample</td><td>normal kidney sample </td><td> </td><td>unknown </td><td>HA1E_KIDNEY </td><td> </td></tr>\n",
"\t<tr><th scope=row>99</th><td>HEK293 </td><td>CVCL_0045</td><td> </td><td>NA</td><td>NA</td><td>24 </td><td>ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%.</td><td> </td><td> </td><td>normal</td><td>Unknown </td><td>F </td><td>Unknown</td><td>kidney </td><td>normal kidney sample</td><td>normal embryonal kidney sample</td><td> </td><td>adherent</td><td> </td><td>293 </td></tr>\n",
"\t<tr><th scope=row>100</th><td>HEKTE </td><td> </td><td> </td><td>NA</td><td>NA</td><td> </td><td> </td><td> </td><td> </td><td>normal</td><td>Unknown </td><td>Unknown</td><td>Unknown</td><td>kidney </td><td>normal kidney sample</td><td>normal kidney sample </td><td> </td><td>unknown </td><td>HEKTE_KIDNEY </td><td>HEK TE </td></tr>\n",
"\t<tr><th scope=row>158</th><td>G401 </td><td>CVCL_0270</td><td>3 months</td><td>NA</td><td>NA</td><td>48 </td><td>McCoys5A </td><td>CRL-1441</td><td>c-108</td><td>tumor </td><td>Caucasian</td><td>M </td><td>Primary</td><td>soft_tissue</td><td>kidney cancer </td><td>carcinoma </td><td>ATCC </td><td>adherent</td><td>G401_SOFT_TISSUE</td><td>G 401|G-401</td></tr>\n",
"\t<tr><th scope=row>236</th><td>RCC10RGB</td><td>CVCL_1647</td><td> </td><td>NA</td><td>NA</td><td>108</td><td>DMEM+ 1%FBS </td><td> </td><td>c-526</td><td>tumor </td><td>Unknown </td><td>M </td><td>Unknown</td><td>kidney </td><td>kidney cancer </td><td>carcinoma </td><td>RIKEN</td><td>adherent</td><td>RCC10RGB_KIDNEY </td><td>10RGB </td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 5 × 20\n",
"\\begin{tabular}{r|llllllllllllllllllll}\n",
" & cell\\_iname & cellosaurus\\_id & donor\\_age & donor\\_age\\_death & donor\\_disease\\_age\\_onset & doubling\\_time & growth\\_medium & provider\\_catalog\\_id & feature\\_id & cell\\_type & donor\\_ethnicity & donor\\_sex & donor\\_tumor\\_phase & cell\\_lineage & primary\\_disease & subtype & provider\\_name & growth\\_pattern & ccle\\_name & cell\\_alias\\\\\n",
" & <chr> & <chr> & <chr> & <lgl> & <lgl> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr>\\\\\n",
"\\hline\n",
"\t98 & HA1E & & & NA & NA & 60 & MEM-ALPHA (Invitrogen A1049001) supplemented with 10\\% v/v fetal bovine serum (Sigma F4135) and 1\\% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016) & & & normal & Unknown & Unknown & Unknown & kidney & normal kidney sample & normal kidney sample & & unknown & HA1E\\_KIDNEY & \\\\\n",
"\t99 & HEK293 & CVCL\\_0045 & & NA & NA & 24 & ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10\\%. & & & normal & Unknown & F & Unknown & kidney & normal kidney sample & normal embryonal kidney sample & & adherent & & 293 \\\\\n",
"\t100 & HEKTE & & & NA & NA & & & & & normal & Unknown & Unknown & Unknown & kidney & normal kidney sample & normal kidney sample & & unknown & HEKTE\\_KIDNEY & HEK TE \\\\\n",
"\t158 & G401 & CVCL\\_0270 & 3 months & NA & NA & 48 & McCoys5A & CRL-1441 & c-108 & tumor & Caucasian & M & Primary & soft\\_tissue & kidney cancer & carcinoma & ATCC & adherent & G401\\_SOFT\\_TISSUE & G 401\\textbar{}G-401\\\\\n",
"\t236 & RCC10RGB & CVCL\\_1647 & & NA & NA & 108 & DMEM+ 1\\%FBS & & c-526 & tumor & Unknown & M & Unknown & kidney & kidney cancer & carcinoma & RIKEN & adherent & RCC10RGB\\_KIDNEY & 10RGB \\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 5 × 20\n",
"\n",
"| <!--/--> | cell_iname <chr> | cellosaurus_id <chr> | donor_age <chr> | donor_age_death <lgl> | donor_disease_age_onset <lgl> | doubling_time <chr> | growth_medium <chr> | provider_catalog_id <chr> | feature_id <chr> | cell_type <chr> | donor_ethnicity <chr> | donor_sex <chr> | donor_tumor_phase <chr> | cell_lineage <chr> | primary_disease <chr> | subtype <chr> | provider_name <chr> | growth_pattern <chr> | ccle_name <chr> | cell_alias <chr> |\n",
"|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
"| 98 | HA1E | <!----> | <!----> | NA | NA | 60 | MEM-ALPHA (Invitrogen A1049001) supplemented with 10% v/v fetal bovine serum (Sigma F4135) and 1% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016) | <!----> | <!----> | normal | Unknown | Unknown | Unknown | kidney | normal kidney sample | normal kidney sample | <!----> | unknown | HA1E_KIDNEY | <!----> |\n",
"| 99 | HEK293 | CVCL_0045 | <!----> | NA | NA | 24 | ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%. | <!----> | <!----> | normal | Unknown | F | Unknown | kidney | normal kidney sample | normal embryonal kidney sample | <!----> | adherent | <!----> | 293 |\n",
"| 100 | HEKTE | <!----> | <!----> | NA | NA | <!----> | <!----> | <!----> | <!----> | normal | Unknown | Unknown | Unknown | kidney | normal kidney sample | normal kidney sample | <!----> | unknown | HEKTE_KIDNEY | HEK TE |\n",
"| 158 | G401 | CVCL_0270 | 3 months | NA | NA | 48 | McCoys5A | CRL-1441 | c-108 | tumor | Caucasian | M | Primary | soft_tissue | kidney cancer | carcinoma | ATCC | adherent | G401_SOFT_TISSUE | G 401|G-401 |\n",
"| 236 | RCC10RGB | CVCL_1647 | <!----> | NA | NA | 108 | DMEM+ 1%FBS | <!----> | c-526 | tumor | Unknown | M | Unknown | kidney | kidney cancer | carcinoma | RIKEN | adherent | RCC10RGB_KIDNEY | 10RGB |\n",
"\n"
],
"text/plain": [
" cell_iname cellosaurus_id donor_age donor_age_death donor_disease_age_onset\n",
"98 HA1E NA NA \n",
"99 HEK293 CVCL_0045 NA NA \n",
"100 HEKTE NA NA \n",
"158 G401 CVCL_0270 3 months NA NA \n",
"236 RCC10RGB CVCL_1647 NA NA \n",
" doubling_time\n",
"98 60 \n",
"99 24 \n",
"100 \n",
"158 48 \n",
"236 108 \n",
" growth_medium \n",
"98 MEM-ALPHA (Invitrogen A1049001) supplemented with 10% v/v fetal bovine serum (Sigma F4135) and 1% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016) \n",
"99 ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%.\n",
"100 \n",
"158 McCoys5A \n",
"236 DMEM+ 1%FBS \n",
" provider_catalog_id feature_id cell_type donor_ethnicity donor_sex\n",
"98 normal Unknown Unknown \n",
"99 normal Unknown F \n",
"100 normal Unknown Unknown \n",
"158 CRL-1441 c-108 tumor Caucasian M \n",
"236 c-526 tumor Unknown M \n",
" donor_tumor_phase cell_lineage primary_disease \n",
"98 Unknown kidney normal kidney sample\n",
"99 Unknown kidney normal kidney sample\n",
"100 Unknown kidney normal kidney sample\n",
"158 Primary soft_tissue kidney cancer \n",
"236 Unknown kidney kidney cancer \n",
" subtype provider_name growth_pattern\n",
"98 normal kidney sample unknown \n",
"99 normal embryonal kidney sample adherent \n",
"100 normal kidney sample unknown \n",
"158 carcinoma ATCC adherent \n",
"236 carcinoma RIKEN adherent \n",
" ccle_name cell_alias \n",
"98 HA1E_KIDNEY \n",
"99 293 \n",
"100 HEKTE_KIDNEY HEK TE \n",
"158 G401_SOFT_TISSUE G 401|G-401\n",
"236 RCC10RGB_KIDNEY 10RGB "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"#kidney cell line\n",
"index <- grep(\"kidney\", cellinfo_beta$primary_disease)\n",
"cellinfo_beta[index,]"
]
},
{
"cell_type": "code",
"execution_count": 38,
"id": "30ad500d-8d9c-48f3-9e21-58fa3b552151",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:23:00.915705Z",
"iopub.status.busy": "2021-09-23T06:23:00.912259Z",
"iopub.status.idle": "2021-09-23T06:23:00.957267Z",
"shell.execute_reply": "2021-09-23T06:23:00.955958Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<dl>\n",
"\t<dt>$`769P`</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$`786O`</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$A704</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$A498</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$ACHN</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$CaKi</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$HEK293</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$RCC</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$HEKTE</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$HA1E</dt>\n",
"\t\t<dd><table class=\"dataframe\">\n",
"<caption>A data.frame: 11 × 5</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><fct></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>67</th><td>aminomethyltransferase__HA1E__trt_cp</td><td>HOXC5</td><td>-2.349426</td><td>aminomethyltransferase</td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>72</th><td>anagrelide__HA1E__trt_cp </td><td>ISL1 </td><td>-2.888882</td><td>anagrelide </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>74</th><td>ARP-101__HA1E__trt_cp </td><td>HOXC5</td><td>-2.420850</td><td>ARP-101 </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>76</th><td>AVA__HA1E__trt_cp </td><td>VENTX</td><td>-2.028199</td><td>AVA </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>101</th><td>BRD-A51929314__HA1E__trt_cp </td><td>ISL1 </td><td>-2.227154</td><td>BRD-A51929314 </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>117</th><td>BRD-K05402890__HA1E__trt_cp </td><td>ISL1 </td><td>-2.309873</td><td>BRD-K05402890 </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>231</th><td>homoharringtonine__HA1E__trt_cp </td><td>HOXC5</td><td>-2.545411</td><td>homoharringtonine </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>282</th><td>R-59022__HA1E__trt_cp </td><td>HOXC5</td><td>-2.440392</td><td>R-59022 </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>303</th><td>ST-638__HA1E__trt_cp </td><td>ISL1 </td><td>-2.139165</td><td>ST-638 </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>314</th><td>tributyltin__HA1E__trt_cp </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin </td><td>HA1E</td></tr>\n",
"\t<tr><th scope=row>315</th><td>triphenyl-tin__HA1E__trt_cp </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin </td><td>HA1E</td></tr>\n",
"</tbody>\n",
"</table>\n",
"</dd>\n",
"\t<dt>$G401</dt>\n",
"\t\t<dd>NULL</dd>\n",
"\t<dt>$RCC10RGB</dt>\n",
"\t\t<dd>NULL</dd>\n",
"</dl>\n"
],
"text/latex": [
"\\begin{description}\n",
"\\item[\\$`769P`] NULL\n",
"\\item[\\$`786O`] NULL\n",
"\\item[\\$A704] NULL\n",
"\\item[\\$A498] NULL\n",
"\\item[\\$ACHN] NULL\n",
"\\item[\\$CaKi] NULL\n",
"\\item[\\$HEK293] NULL\n",
"\\item[\\$RCC] NULL\n",
"\\item[\\$HEKTE] NULL\n",
"\\item[\\$HA1E] A data.frame: 11 × 5\n",
"\\begin{tabular}{r|lllll}\n",
" & Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
" & <chr> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
"\\hline\n",
"\t67 & aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.349426 & aminomethyltransferase & HA1E\\\\\n",
"\t72 & anagrelide\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.888882 & anagrelide & HA1E\\\\\n",
"\t74 & ARP-101\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.420850 & ARP-101 & HA1E\\\\\n",
"\t76 & AVA\\_\\_HA1E\\_\\_trt\\_cp & VENTX & -2.028199 & AVA & HA1E\\\\\n",
"\t101 & BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.227154 & BRD-A51929314 & HA1E\\\\\n",
"\t117 & BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.309873 & BRD-K05402890 & HA1E\\\\\n",
"\t231 & homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.545411 & homoharringtonine & HA1E\\\\\n",
"\t282 & R-59022\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.440392 & R-59022 & HA1E\\\\\n",
"\t303 & ST-638\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.139165 & ST-638 & HA1E\\\\\n",
"\t314 & tributyltin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -3.094550 & tributyltin & HA1E\\\\\n",
"\t315 & triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.005953 & triphenyl-tin & HA1E\\\\\n",
"\\end{tabular}\n",
"\n",
"\\item[\\$G401] NULL\n",
"\\item[\\$RCC10RGB] NULL\n",
"\\end{description}\n"
],
"text/markdown": [
"$`769P`\n",
": NULL\n",
"$`786O`\n",
": NULL\n",
"$A704\n",
": NULL\n",
"$A498\n",
": NULL\n",
"$ACHN\n",
": NULL\n",
"$CaKi\n",
": NULL\n",
"$HEK293\n",
": NULL\n",
"$RCC\n",
": NULL\n",
"$HEKTE\n",
": NULL\n",
"$HA1E\n",
": \n",
"A data.frame: 11 × 5\n",
"\n",
"| <!--/--> | Drug <chr> | TF <chr> | ZSCORE <dbl> | Drug.name <fct> | cellLine <chr> |\n",
"|---|---|---|---|---|---|\n",
"| 67 | aminomethyltransferase__HA1E__trt_cp | HOXC5 | -2.349426 | aminomethyltransferase | HA1E |\n",
"| 72 | anagrelide__HA1E__trt_cp | ISL1 | -2.888882 | anagrelide | HA1E |\n",
"| 74 | ARP-101__HA1E__trt_cp | HOXC5 | -2.420850 | ARP-101 | HA1E |\n",
"| 76 | AVA__HA1E__trt_cp | VENTX | -2.028199 | AVA | HA1E |\n",
"| 101 | BRD-A51929314__HA1E__trt_cp | ISL1 | -2.227154 | BRD-A51929314 | HA1E |\n",
"| 117 | BRD-K05402890__HA1E__trt_cp | ISL1 | -2.309873 | BRD-K05402890 | HA1E |\n",
"| 231 | homoharringtonine__HA1E__trt_cp | HOXC5 | -2.545411 | homoharringtonine | HA1E |\n",
"| 282 | R-59022__HA1E__trt_cp | HOXC5 | -2.440392 | R-59022 | HA1E |\n",
"| 303 | ST-638__HA1E__trt_cp | ISL1 | -2.139165 | ST-638 | HA1E |\n",
"| 314 | tributyltin__HA1E__trt_cp | ISL1 | -3.094550 | tributyltin | HA1E |\n",
"| 315 | triphenyl-tin__HA1E__trt_cp | ISL1 | -2.005953 | triphenyl-tin | HA1E |\n",
"\n",
"\n",
"$G401\n",
": NULL\n",
"$RCC10RGB\n",
": NULL\n",
"\n",
"\n"
],
"text/plain": [
"$`769P`\n",
"NULL\n",
"\n",
"$`786O`\n",
"NULL\n",
"\n",
"$A704\n",
"NULL\n",
"\n",
"$A498\n",
"NULL\n",
"\n",
"$ACHN\n",
"NULL\n",
"\n",
"$CaKi\n",
"NULL\n",
"\n",
"$HEK293\n",
"NULL\n",
"\n",
"$RCC\n",
"NULL\n",
"\n",
"$HEKTE\n",
"NULL\n",
"\n",
"$HA1E\n",
" Drug TF ZSCORE Drug.name\n",
"67 aminomethyltransferase__HA1E__trt_cp HOXC5 -2.349426 aminomethyltransferase\n",
"72 anagrelide__HA1E__trt_cp ISL1 -2.888882 anagrelide\n",
"74 ARP-101__HA1E__trt_cp HOXC5 -2.420850 ARP-101\n",
"76 AVA__HA1E__trt_cp VENTX -2.028199 AVA\n",
"101 BRD-A51929314__HA1E__trt_cp ISL1 -2.227154 BRD-A51929314\n",
"117 BRD-K05402890__HA1E__trt_cp ISL1 -2.309873 BRD-K05402890\n",
"231 homoharringtonine__HA1E__trt_cp HOXC5 -2.545411 homoharringtonine\n",
"282 R-59022__HA1E__trt_cp HOXC5 -2.440392 R-59022\n",
"303 ST-638__HA1E__trt_cp ISL1 -2.139165 ST-638\n",
"314 tributyltin__HA1E__trt_cp ISL1 -3.094550 tributyltin\n",
"315 triphenyl-tin__HA1E__trt_cp ISL1 -2.005953 triphenyl-tin\n",
" cellLine\n",
"67 HA1E\n",
"72 HA1E\n",
"74 HA1E\n",
"76 HA1E\n",
"101 HA1E\n",
"117 HA1E\n",
"231 HA1E\n",
"282 HA1E\n",
"303 HA1E\n",
"314 HA1E\n",
"315 HA1E\n",
"\n",
"$G401\n",
"NULL\n",
"\n",
"$RCC10RGB\n",
"NULL\n"
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"#Engineered Kidney --- HA1E, HA1E,HK2\n",
"#kidney; Embryo --- HEK293T\n",
"RCCl.cellLines <- c(\"769P\", \"786O\", \"A704\", \"A498\", \"ACHN\", \"CaKi\", \"HEK293\", \"RCC\", \"HEKTE\", \"HA1E\", \"G401\", \"RCC10RGB\")\n",
"RCC.drug.results <- sapply(RCCl.cellLines, function(x){\n",
" index <- grep(x, drug.result$Drug)\n",
" if(length(index)>0){\n",
" return(drug.result[index,])\n",
" }else{\n",
" return(NULL)\n",
" }\n",
"})\n",
"RCC.drug.results"
]
},
{
"cell_type": "code",
"execution_count": 39,
"id": "9d42620e-ae65-45f2-a333-056cd55d70a1",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:23:08.276912Z",
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"shell.execute_reply": "2021-09-23T06:23:08.316167Z"
},
"tags": [],
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}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 11 × 5</caption>\n",
"<thead>\n",
"\t<tr><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
"\t<tr><th scope=col><fct></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><fct></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>HOXC5</td><td>-2.349426</td><td>aminomethyltransferase</td><td>HA1E</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>ISL1 </td><td>-2.888882</td><td>anagrelide </td><td>HA1E</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>HOXC5</td><td>-2.420850</td><td>ARP-101 </td><td>HA1E</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>VENTX</td><td>-2.028199</td><td>AVA </td><td>HA1E</td></tr>\n",
"\t<tr><td>BRD-A51929314__HA1E__trt_cp </td><td>ISL1 </td><td>-2.227154</td><td>BRD-A51929314 </td><td>HA1E</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>ISL1 </td><td>-2.309873</td><td>BRD-K05402890 </td><td>HA1E</td></tr>\n",
"\t<tr><td>homoharringtonine__HA1E__trt_cp </td><td>HOXC5</td><td>-2.545411</td><td>homoharringtonine </td><td>HA1E</td></tr>\n",
"\t<tr><td>R-59022__HA1E__trt_cp </td><td>HOXC5</td><td>-2.440392</td><td>R-59022 </td><td>HA1E</td></tr>\n",
"\t<tr><td>ST-638__HA1E__trt_cp </td><td>ISL1 </td><td>-2.139165</td><td>ST-638 </td><td>HA1E</td></tr>\n",
"\t<tr><td>tributyltin__HA1E__trt_cp </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin </td><td>HA1E</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin </td><td>HA1E</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 11 × 5\n",
"\\begin{tabular}{lllll}\n",
" Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
" <fct> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
"\\hline\n",
"\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.349426 & aminomethyltransferase & HA1E\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.888882 & anagrelide & HA1E\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.420850 & ARP-101 & HA1E\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & VENTX & -2.028199 & AVA & HA1E\\\\\n",
"\t BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.227154 & BRD-A51929314 & HA1E\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.309873 & BRD-K05402890 & HA1E\\\\\n",
"\t homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.545411 & homoharringtonine & HA1E\\\\\n",
"\t R-59022\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.440392 & R-59022 & HA1E\\\\\n",
"\t ST-638\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.139165 & ST-638 & HA1E\\\\\n",
"\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -3.094550 & tributyltin & HA1E\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.005953 & triphenyl-tin & HA1E\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 11 × 5\n",
"\n",
"| Drug <fct> | TF <chr> | ZSCORE <dbl> | Drug.name <fct> | cellLine <chr> |\n",
"|---|---|---|---|---|\n",
"| aminomethyltransferase__HA1E__trt_cp | HOXC5 | -2.349426 | aminomethyltransferase | HA1E |\n",
"| anagrelide__HA1E__trt_cp | ISL1 | -2.888882 | anagrelide | HA1E |\n",
"| ARP-101__HA1E__trt_cp | HOXC5 | -2.420850 | ARP-101 | HA1E |\n",
"| AVA__HA1E__trt_cp | VENTX | -2.028199 | AVA | HA1E |\n",
"| BRD-A51929314__HA1E__trt_cp | ISL1 | -2.227154 | BRD-A51929314 | HA1E |\n",
"| BRD-K05402890__HA1E__trt_cp | ISL1 | -2.309873 | BRD-K05402890 | HA1E |\n",
"| homoharringtonine__HA1E__trt_cp | HOXC5 | -2.545411 | homoharringtonine | HA1E |\n",
"| R-59022__HA1E__trt_cp | HOXC5 | -2.440392 | R-59022 | HA1E |\n",
"| ST-638__HA1E__trt_cp | ISL1 | -2.139165 | ST-638 | HA1E |\n",
"| tributyltin__HA1E__trt_cp | ISL1 | -3.094550 | tributyltin | HA1E |\n",
"| triphenyl-tin__HA1E__trt_cp | ISL1 | -2.005953 | triphenyl-tin | HA1E |\n",
"\n"
],
"text/plain": [
" Drug TF ZSCORE Drug.name \n",
"1 aminomethyltransferase__HA1E__trt_cp HOXC5 -2.349426 aminomethyltransferase\n",
"2 anagrelide__HA1E__trt_cp ISL1 -2.888882 anagrelide \n",
"3 ARP-101__HA1E__trt_cp HOXC5 -2.420850 ARP-101 \n",
"4 AVA__HA1E__trt_cp VENTX -2.028199 AVA \n",
"5 BRD-A51929314__HA1E__trt_cp ISL1 -2.227154 BRD-A51929314 \n",
"6 BRD-K05402890__HA1E__trt_cp ISL1 -2.309873 BRD-K05402890 \n",
"7 homoharringtonine__HA1E__trt_cp HOXC5 -2.545411 homoharringtonine \n",
"8 R-59022__HA1E__trt_cp HOXC5 -2.440392 R-59022 \n",
"9 ST-638__HA1E__trt_cp ISL1 -2.139165 ST-638 \n",
"10 tributyltin__HA1E__trt_cp ISL1 -3.094550 tributyltin \n",
"11 triphenyl-tin__HA1E__trt_cp ISL1 -2.005953 triphenyl-tin \n",
" cellLine\n",
"1 HA1E \n",
"2 HA1E \n",
"3 HA1E \n",
"4 HA1E \n",
"5 HA1E \n",
"6 HA1E \n",
"7 HA1E \n",
"8 HA1E \n",
"9 HA1E \n",
"10 HA1E \n",
"11 HA1E "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"####output\n",
"RCC.drug.result <- rbind(RCC.drug.results[[7]], RCC.drug.results[[10]])\n",
"library (plyr)\n",
"library(writexl)\n",
"drug.idx <- sort(table(RCC.drug.result$Drug),decreasing = T)\n",
"RCC.drug.result$Drug <- factor(RCC.drug.result$Drug, levels = names(drug.idx))\n",
"RCC.drug.result <- arrange(RCC.drug.result, Drug)\n",
"write_xlsx(RCC.drug.result, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.negative.drug.result.xlsx\")\n",
"RCC.drug.result"
]
},
{
"cell_type": "code",
"execution_count": 40,
"id": "ab3e7788-a5fe-46ec-ba50-c149a53e81fb",
"metadata": {
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"scrolled": true,
"tags": [],
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},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 52 × 36</caption>\n",
"<thead>\n",
"\t<tr><th scope=col>.id</th><th scope=col>bead_batch</th><th scope=col>nearest_dose</th><th scope=col>pert_dose</th><th scope=col>pert_dose_unit</th><th scope=col>pert_idose</th><th scope=col>pert_itime</th><th scope=col>pert_time</th><th scope=col>pert_time_unit</th><th scope=col>cell_mfc_name</th><th scope=col>⋯</th><th scope=col>sig_id</th><th scope=col>pert_type</th><th scope=col>cell_iname</th><th scope=col>det_wells</th><th scope=col>det_plates</th><th scope=col>distil_ids</th><th scope=col>build_name</th><th scope=col>project_code</th><th scope=col>cmap_name</th><th scope=col>is_ncs_exemplar</th></tr>\n",
"\t<tr><th scope=col><chr></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><dbl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col>⋯</th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><lgl></th><th scope=col><chr></th><th scope=col><chr></th><th scope=col><int></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC001_HA1E_24H:BRD-A28318179-003-03-6:10 </td><td>trt_cp</td><td>HA1E</td><td>J07 </td><td>CPC001_HA1E_24H_X1_B3_DUO52HI53LO|CPC001_HA1E_24H_X2_B3_DUO52HI53LO|CPC001_HA1E_24H_X3_B3_DUO52HI53LO </td><td>CPC001_HA1E_24H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X3_B3_DUO52HI53LO:J07 </td><td>NA</td><td>CPC </td><td>aminomethyltransferase</td><td>0</td></tr>\n",
"\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC001_HA1E_6H:BRD-A28318179-003-03-6:10 </td><td>trt_cp</td><td>HA1E</td><td>J07 </td><td>CPC001_HA1E_6H_X1_B3_DUO52HI53LO|CPC001_HA1E_6H_X2_B3_DUO52HI53LO|CPC001_HA1E_6H_X3_B3_DUO52HI53LO </td><td>CPC001_HA1E_6H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X3_B3_DUO52HI53LO:J07 </td><td>NA</td><td>CPC </td><td>aminomethyltransferase</td><td>1</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC004_HA1E_6H:BRD-K62200014-003-05-5:10 </td><td>trt_cp</td><td>HA1E</td><td>L03 </td><td>CPC004_HA1E_6H_X1_B3_DUO52HI53LO|CPC004_HA1E_6H_X2_B3_DUO52HI53LO|CPC004_HA1E_6H_X3_B3_DUO52HI53LO </td><td>CPC004_HA1E_6H_X1_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X2_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X3_B3_DUO52HI53LO:L03 </td><td>NA</td><td>CPC </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>f1b3</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC011_HA1E_6H:BRD-K62200014-003-07-1:10 </td><td>trt_cp</td><td>HA1E</td><td>H10 </td><td>CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO </td><td>CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO:H10|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO:H10 </td><td>NA</td><td>CPC </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b23 </td><td> 0.740</td><td> 0.76923100</td><td>uM</td><td>0.74 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B14 </td><td>trt_cp</td><td>HA1E</td><td>B14 </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 </td><td>REP.B018_HA1E_24H_X1_B23:B14|REP.B018_HA1E_24H_X2_B23:B14 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>1</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b24 </td><td> 1.110</td><td> 1.11111000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B15 </td><td>trt_cp</td><td>HA1E</td><td>B15 </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 </td><td>REP.A018_HA1E_24H_X1_B24:B15|REP.A018_HA1E_24H_X2_B23:B15|REP.A018_HA1E_24H_X3_B23:B15 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b24 </td><td> 0.040</td><td> 0.04115230</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B18 </td><td>trt_cp</td><td>HA1E</td><td>B18 </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 </td><td>REP.A018_HA1E_24H_X1_B24:B18|REP.A018_HA1E_24H_X2_B23:B18|REP.A018_HA1E_24H_X3_B23:B18 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b23 </td><td> 0.080</td><td> 0.08547010</td><td>uM</td><td>0.08 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B16 </td><td>trt_cp</td><td>HA1E</td><td>B16 </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 </td><td>REP.B018_HA1E_24H_X1_B23:B16|REP.B018_HA1E_24H_X2_B23:B16 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b24 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B13 </td><td>trt_cp</td><td>HA1E</td><td>B13 </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 </td><td>REP.A018_HA1E_24H_X1_B24:B13|REP.A018_HA1E_24H_X2_B23:B13|REP.A018_HA1E_24H_X3_B23:B13 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b23 </td><td> 0.250</td><td> 0.25641000</td><td>uM</td><td>0.25 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B15 </td><td>trt_cp</td><td>HA1E</td><td>B15 </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 </td><td>REP.B018_HA1E_24H_X1_B23:B15|REP.B018_HA1E_24H_X2_B23:B15 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b24 </td><td> 0.125</td><td> 0.12345700</td><td>uM</td><td>0.125 uM</td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B17 </td><td>trt_cp</td><td>HA1E</td><td>B17 </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 </td><td>REP.A018_HA1E_24H_X1_B24:B17|REP.A018_HA1E_24H_X2_B23:B17|REP.A018_HA1E_24H_X3_B23:B17 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b23 </td><td> 0.010</td><td> 0.00949668</td><td>uM</td><td>0.01 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B18 </td><td>trt_cp</td><td>HA1E</td><td>B18 </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 </td><td>REP.B018_HA1E_24H_X1_B23:B18|REP.B018_HA1E_24H_X2_B23:B18 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b24 </td><td> 0.370</td><td> 0.37037000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B16 </td><td>trt_cp</td><td>HA1E</td><td>B16 </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 </td><td>REP.A018_HA1E_24H_X1_B24:B16|REP.A018_HA1E_24H_X2_B23:B16|REP.A018_HA1E_24H_X3_B23:B16 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b24 </td><td> 3.330</td><td> 3.33333000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B14 </td><td>trt_cp</td><td>HA1E</td><td>B14 </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 </td><td>REP.A018_HA1E_24H_X1_B24:B14|REP.A018_HA1E_24H_X2_B23:B14|REP.A018_HA1E_24H_X3_B23:B14 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b23 </td><td> 2.220</td><td> 2.30769000</td><td>uM</td><td>2.22 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B13 </td><td>trt_cp</td><td>HA1E</td><td>B13 </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 </td><td>REP.B018_HA1E_24H_X1_B23:B13|REP.B018_HA1E_24H_X2_B23:B13 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>b23 </td><td> 0.030</td><td> 0.02849000</td><td>uM</td><td>0.03 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B17 </td><td>trt_cp</td><td>HA1E</td><td>B17 </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 </td><td>REP.B018_HA1E_24H_X1_B23:B17|REP.B018_HA1E_24H_X2_B23:B17 </td><td>NA</td><td>REP </td><td>anagrelide </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC006_HA1E_6H:BRD-K73395020-001-01-5:10 </td><td>trt_cp</td><td>HA1E</td><td>K04 </td><td>CPC006_HA1E_6H_X1_B3_DUO52HI53LO|CPC006_HA1E_6H_X2_B3_DUO52HI53LO|CPC006_HA1E_6H_X3_B3_DUO52HI53LO|CPC006_HA1E_6H_X4_B4_DUO52HI53LO|CPC006_HA1E_6H_X5_B4_DUO52HI53LO</td><td>CPC006_HA1E_6H_X1_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X2_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X3_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X4_B4_DUO52HI53LO:K04|CPC006_HA1E_6H_X5_B4_DUO52HI53LO:K04 </td><td>NA</td><td>CPC </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b24 </td><td> 0.030</td><td> 0.02849000</td><td>uM</td><td>0.03 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M17 </td><td>trt_cp</td><td>HA1E</td><td>M17 </td><td>REP.B007_HA1E_24H_X1_B24 </td><td>REP.B007_HA1E_24H_X1_B24:M17 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b22 </td><td> 0.040</td><td> 0.04115230</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M18 </td><td>trt_cp</td><td>HA1E</td><td>M18 </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 </td><td>REP.A007_HA1E_24H_X1_B22:M18|REP.A007_HA1E_24H_X2_B24:M18|REP.A007_HA1E_24H_X3_B22:M18 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b24 </td><td> 0.250</td><td> 0.25641000</td><td>uM</td><td>0.25 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M15 </td><td>trt_cp</td><td>HA1E</td><td>M15 </td><td>REP.B007_HA1E_24H_X1_B24 </td><td>REP.B007_HA1E_24H_X1_B24:M15 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b22 </td><td> 0.125</td><td> 0.12345700</td><td>uM</td><td>0.125 uM</td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M17 </td><td>trt_cp</td><td>HA1E</td><td>M17 </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 </td><td>REP.A007_HA1E_24H_X1_B22:M17|REP.A007_HA1E_24H_X2_B24:M17|REP.A007_HA1E_24H_X3_B22:M17 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b24 </td><td> 2.220</td><td> 2.30769000</td><td>uM</td><td>2.22 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M13 </td><td>trt_cp</td><td>HA1E</td><td>M13 </td><td>REP.B007_HA1E_24H_X1_B24 </td><td>REP.B007_HA1E_24H_X1_B24:M13 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b24 </td><td> 0.010</td><td> 0.00949668</td><td>uM</td><td>0.01 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M18 </td><td>trt_cp</td><td>HA1E</td><td>M18 </td><td>REP.B007_HA1E_24H_X1_B24 </td><td>REP.B007_HA1E_24H_X1_B24:M18 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b24 </td><td> 0.080</td><td> 0.08547010</td><td>uM</td><td>0.08 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M16 </td><td>trt_cp</td><td>HA1E</td><td>M16 </td><td>REP.B007_HA1E_24H_X1_B24 </td><td>REP.B007_HA1E_24H_X1_B24:M16 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b22 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M13 </td><td>trt_cp</td><td>HA1E</td><td>M13 </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 </td><td>REP.A007_HA1E_24H_X1_B22:M13|REP.A007_HA1E_24H_X2_B24:M13|REP.A007_HA1E_24H_X3_B22:M13 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b22 </td><td> 0.370</td><td> 0.37037000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M16 </td><td>trt_cp</td><td>HA1E</td><td>M16 </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X3_B22 </td><td>REP.A007_HA1E_24H_X1_B22:M16|REP.A007_HA1E_24H_X3_B22:M16 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b22 </td><td> 1.110</td><td> 1.11111000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M15 </td><td>trt_cp</td><td>HA1E</td><td>M15 </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 </td><td>REP.A007_HA1E_24H_X1_B22:M15|REP.A007_HA1E_24H_X2_B24:M15|REP.A007_HA1E_24H_X3_B22:M15 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b22 </td><td> 3.330</td><td> 3.33333000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M14 </td><td>trt_cp</td><td>HA1E</td><td>M14 </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 </td><td>REP.A007_HA1E_24H_X1_B22:M14|REP.A007_HA1E_24H_X2_B24:M14|REP.A007_HA1E_24H_X3_B22:M14 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>1</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>b24 </td><td> 0.740</td><td> 0.76923100</td><td>uM</td><td>0.74 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M14 </td><td>trt_cp</td><td>HA1E</td><td>M14 </td><td>REP.B007_HA1E_24H_X1_B24 </td><td>REP.B007_HA1E_24H_X1_B24:M14 </td><td>NA</td><td>REP </td><td>ARP-101 </td><td>0</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>b13 </td><td> 3.330</td><td> 3.33000000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:3.33 </td><td>trt_cp</td><td>HA1E</td><td>N20 </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 </td><td>PCLB003_HA1E_24H_X1_B13:N20|PCLB003_HA1E_24H_X2_B13:N20|PCLB003_HA1E_24H_X3_B13:N20 </td><td>NA</td><td>PCLB </td><td>AVA </td><td>0</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>b13 </td><td> 0.370</td><td> 0.37000000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.37 </td><td>trt_cp</td><td>HA1E</td><td>N22 </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 </td><td>PCLB003_HA1E_24H_X1_B13:N22|PCLB003_HA1E_24H_X2_B13:N22|PCLB003_HA1E_24H_X3_B13:N22 </td><td>NA</td><td>PCLB </td><td>AVA </td><td>0</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>b13 </td><td> 1.110</td><td> 1.11000000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:1.11 </td><td>trt_cp</td><td>HA1E</td><td>N21 </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 </td><td>PCLB003_HA1E_24H_X1_B13:N21|PCLB003_HA1E_24H_X2_B13:N21|PCLB003_HA1E_24H_X3_B13:N21 </td><td>NA</td><td>PCLB </td><td>AVA </td><td>0</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>b13 </td><td> 0.040</td><td> 0.04000000</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.04 </td><td>trt_cp</td><td>HA1E</td><td>N24 </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 </td><td>PCLB003_HA1E_24H_X1_B13:N24|PCLB003_HA1E_24H_X2_B13:N24|PCLB003_HA1E_24H_X3_B13:N24 </td><td>NA</td><td>PCLB </td><td>AVA </td><td>0</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>b13 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:10 </td><td>trt_cp</td><td>HA1E</td><td>N19 </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 </td><td>PCLB003_HA1E_24H_X1_B13:N19|PCLB003_HA1E_24H_X2_B13:N19|PCLB003_HA1E_24H_X3_B13:N19 </td><td>NA</td><td>PCLB </td><td>AVA </td><td>1</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>b13 </td><td> 0.120</td><td> 0.12000000</td><td>uM</td><td>0.12 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.12 </td><td>trt_cp</td><td>HA1E</td><td>N23 </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 </td><td>PCLB003_HA1E_24H_X1_B13:N23|PCLB003_HA1E_24H_X2_B13:N23|PCLB003_HA1E_24H_X3_B13:N23 </td><td>NA</td><td>PCLB </td><td>AVA </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>f1b3</td><td> 0.370</td><td> 0.35000000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC006_HA1E_24H:N13 </td><td>trt_cp</td><td>HA1E</td><td>N13 </td><td>CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO|CPC006_HA1E_24H_X2_B3_DUO52HI53LO|CPC006_HA1E_24H_X3_B3_DUO52HI53LO </td><td>CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X2_B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X3_B3_DUO52HI53LO:N13 </td><td>NA</td><td>CPC </td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC007_HA1E_24H:BRD-K05402890-001-09-2:10 </td><td>trt_cp</td><td>HA1E</td><td>H03 </td><td>CPC007_HA1E_24H_X1_B3_DUO52HI53LO|CPC007_HA1E_24H_X2_B3_DUO52HI53LO|CPC007_HA1E_24H_X3_B3_DUO52HI53LO </td><td>CPC007_HA1E_24H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X3_B3_DUO52HI53LO:H03 </td><td>NA</td><td>CPC </td><td>BRD-K05402890 </td><td>1</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC007_HA1E_6H:BRD-K05402890-001-09-2:10 </td><td>trt_cp</td><td>HA1E</td><td>H03 </td><td>CPC007_HA1E_6H_X1_B3_DUO52HI53LO|CPC007_HA1E_6H_X2_B3_DUO52HI53LO|CPC007_HA1E_6H_X3_B3_DUO52HI53LO </td><td>CPC007_HA1E_6H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X3_B3_DUO52HI53LO:H03 </td><td>NA</td><td>CPC </td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b21 </td><td> 0.370</td><td> 0.37037000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L04 </td><td>trt_cp</td><td>HA1E</td><td>L04 </td><td>PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 </td><td>PBIOA014_HA1E_24H_X2_B21:L04|PBIOA014_HA1E_24H_X3_B21:L04 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b21 </td><td> 0.125</td><td> 0.12345700</td><td>uM</td><td>0.125 uM</td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L05 </td><td>trt_cp</td><td>HA1E</td><td>L05 </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 </td><td>PBIOA014_HA1E_24H_X1_B21:L05|PBIOA014_HA1E_24H_X2_B21:L05|PBIOA014_HA1E_24H_X3_B21:L05 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b21 </td><td> 3.330</td><td> 3.33333000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L02 </td><td>trt_cp</td><td>HA1E</td><td>L02 </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 </td><td>PBIOA014_HA1E_24H_X1_B21:L02|PBIOA014_HA1E_24H_X2_B21:L02|PBIOA014_HA1E_24H_X3_B21:L02 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b21 </td><td> 1.110</td><td> 1.11111000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L03 </td><td>trt_cp</td><td>HA1E</td><td>L03 </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 </td><td>PBIOA014_HA1E_24H_X1_B21:L03|PBIOA014_HA1E_24H_X2_B21:L03|PBIOA014_HA1E_24H_X3_B21:L03 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b21 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L01 </td><td>trt_cp</td><td>HA1E</td><td>L01 </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 </td><td>PBIOA014_HA1E_24H_X1_B21:L01|PBIOA014_HA1E_24H_X2_B21:L01|PBIOA014_HA1E_24H_X3_B21:L01 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>b21 </td><td> 0.040</td><td> 0.04115230</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L06 </td><td>trt_cp</td><td>HA1E</td><td>L06 </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 </td><td>PBIOA014_HA1E_24H_X1_B21:L06|PBIOA014_HA1E_24H_X2_B21:L06|PBIOA014_HA1E_24H_X3_B21:L06 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890 </td><td>0</td></tr>\n",
"\t<tr><td>R-59022__HA1E__trt_cp </td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC005_HA1E_6H:BRD-K54665485-001-04-6:10 </td><td>trt_cp</td><td>HA1E</td><td>P15 </td><td>CPC005_HA1E_6H_X3_B3_DUO52HI53LO </td><td>CPC005_HA1E_6H_X3_B3_DUO52HI53LO:P15 </td><td>NA</td><td>CPC </td><td>R-59022 </td><td>0</td></tr>\n",
"\t<tr><td>ST-638__HA1E__trt_cp </td><td>b3 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC005_HA1E_6H:BRD-K51476772-001-01-9:10 </td><td>trt_cp</td><td>HA1E</td><td>D03 </td><td>CPC005_HA1E_6H_X1_B3_DUO52HI53LO|CPC005_HA1E_6H_X3_B3_DUO52HI53LO </td><td>CPC005_HA1E_6H_X1_B3_DUO52HI53LO:D03|CPC005_HA1E_6H_X3_B3_DUO52HI53LO:D03 </td><td>NA</td><td>CPC </td><td>ST-638 </td><td>0</td></tr>\n",
"\t<tr><td>tributyltin__HA1E__trt_cp </td><td>f1b7</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN004_HA1E_6H:BRD-K88145757-001-01-6:10 </td><td>trt_cp</td><td>HA1E</td><td>H15|I13|L18 </td><td>CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO </td><td>CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:H15|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:I13|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:L18 </td><td>NA</td><td>CRCGN</td><td>tributyltin </td><td>0</td></tr>\n",
"\t<tr><td>tributyltin__HA1E__trt_cp </td><td>f1b4</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN001_HA1E_24H:BRD-K88145757-001-01-6:10 </td><td>trt_cp</td><td>HA1E</td><td>H15|I13 </td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO </td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:H15|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:I13 </td><td>NA</td><td>CRCGN</td><td>tributyltin </td><td>1</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>f1b7</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10 </td><td>trt_cp</td><td>HA1E</td><td>D19|F18|G07 </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07 </td><td>NA</td><td>CRCGN</td><td>triphenyl-tin </td><td>0</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>f1b7</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10UM</td><td>trt_cp</td><td>HA1E</td><td>D19|F18|G07 </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07 </td><td>NA</td><td>CRCGN</td><td>triphenyl-tin </td><td>0</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>f1b4</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN001_HA1E_6H:BRD-K78683072-001-01-6:10 </td><td>trt_cp</td><td>HA1E</td><td>D19|F18|G07 </td><td>CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO </td><td>CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:G07 </td><td>NA</td><td>CRCGN</td><td>triphenyl-tin </td><td>0</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>f1b4</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN001_HA1E_24H:BRD-K78683072-001-01-6:10 </td><td>trt_cp</td><td>HA1E</td><td>D14|D19|F18|G07|K11</td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO </td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:K11|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:G07</td><td>NA</td><td>CRCGN</td><td>triphenyl-tin </td><td>0</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 52 × 36\n",
"\\begin{tabular}{lllllllllllllllllllll}\n",
" .id & bead\\_batch & nearest\\_dose & pert\\_dose & pert\\_dose\\_unit & pert\\_idose & pert\\_itime & pert\\_time & pert\\_time\\_unit & cell\\_mfc\\_name & ⋯ & sig\\_id & pert\\_type & cell\\_iname & det\\_wells & det\\_plates & distil\\_ids & build\\_name & project\\_code & cmap\\_name & is\\_ncs\\_exemplar\\\\\n",
" <chr> & <chr> & <dbl> & <dbl> & <chr> & <chr> & <chr> & <dbl> & <chr> & <chr> & ⋯ & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <lgl> & <chr> & <chr> & <int>\\\\\n",
"\\hline\n",
"\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & CPC001\\_HA1E\\_24H:BRD-A28318179-003-03-6:10 & trt\\_cp & HA1E & J07 & CPC001\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO & CPC001\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO:J07 & NA & CPC & aminomethyltransferase & 0\\\\\n",
"\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC001\\_HA1E\\_6H:BRD-A28318179-003-03-6:10 & trt\\_cp & HA1E & J07 & CPC001\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO & CPC001\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:J07 & NA & CPC & aminomethyltransferase & 1\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC004\\_HA1E\\_6H:BRD-K62200014-003-05-5:10 & trt\\_cp & HA1E & L03 & CPC004\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC004\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC004\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO & CPC004\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:L03\\textbar{}CPC004\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:L03\\textbar{}CPC004\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:L03 & NA & CPC & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & f1b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC011\\_HA1E\\_6H:BRD-K62200014-003-07-1:10 & trt\\_cp & HA1E & H10 & CPC011\\_HA1E\\_6H\\_X1\\_F1B3\\_DUO52HI53LO\\textbar{}CPC011\\_HA1E\\_6H\\_X3\\_F1B3\\_DUO52HI53LO & CPC011\\_HA1E\\_6H\\_X1\\_F1B3\\_DUO52HI53LO:H10\\textbar{}CPC011\\_HA1E\\_6H\\_X3\\_F1B3\\_DUO52HI53LO:H10 & NA & CPC & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b23 & 0.740 & 0.76923100 & uM & 0.74 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B14 & trt\\_cp & HA1E & B14 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23 & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B14\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B14 & NA & REP & anagrelide & 1\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b24 & 1.110 & 1.11111000 & uM & 1.11 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B15 & trt\\_cp & HA1E & B15 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23 & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B15\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B15\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B15 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.040 & 0.04115230 & uM & 0.04 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B18 & trt\\_cp & HA1E & B18 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23 & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B18\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B18\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B18 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b23 & 0.080 & 0.08547010 & uM & 0.08 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B16 & trt\\_cp & HA1E & B16 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23 & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B16\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B16 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b24 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B13 & trt\\_cp & HA1E & B13 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23 & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B13\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B13\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B13 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b23 & 0.250 & 0.25641000 & uM & 0.25 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B15 & trt\\_cp & HA1E & B15 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23 & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B15\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B15 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.125 & 0.12345700 & uM & 0.125 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B17 & trt\\_cp & HA1E & B17 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23 & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B17\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B17\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B17 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b23 & 0.010 & 0.00949668 & uM & 0.01 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B18 & trt\\_cp & HA1E & B18 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23 & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B18\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B18 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.370 & 0.37037000 & uM & 0.37 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B16 & trt\\_cp & HA1E & B16 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23 & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B16\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B16\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B16 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b24 & 3.330 & 3.33333000 & uM & 3.33 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B14 & trt\\_cp & HA1E & B14 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23 & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B14\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B14\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B14 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b23 & 2.220 & 2.30769000 & uM & 2.22 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B13 & trt\\_cp & HA1E & B13 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23 & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B13\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B13 & NA & REP & anagrelide & 0\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & b23 & 0.030 & 0.02849000 & uM & 0.03 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B17 & trt\\_cp & HA1E & B17 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23 & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B17\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B17 & NA & REP & anagrelide & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC006\\_HA1E\\_6H:BRD-K73395020-001-01-5:10 & trt\\_cp & HA1E & K04 & CPC006\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X4\\_B4\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X5\\_B4\\_DUO52HI53LO & CPC006\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X4\\_B4\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X5\\_B4\\_DUO52HI53LO:K04 & NA & CPC & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.030 & 0.02849000 & uM & 0.03 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M17 & trt\\_cp & HA1E & M17 & REP.B007\\_HA1E\\_24H\\_X1\\_B24 & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M17 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b22 & 0.040 & 0.04115230 & uM & 0.04 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M18 & trt\\_cp & HA1E & M18 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22 & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M18\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M18\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M18 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.250 & 0.25641000 & uM & 0.25 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M15 & trt\\_cp & HA1E & M15 & REP.B007\\_HA1E\\_24H\\_X1\\_B24 & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M15 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b22 & 0.125 & 0.12345700 & uM & 0.125 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M17 & trt\\_cp & HA1E & M17 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22 & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M17\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M17\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M17 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b24 & 2.220 & 2.30769000 & uM & 2.22 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M13 & trt\\_cp & HA1E & M13 & REP.B007\\_HA1E\\_24H\\_X1\\_B24 & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M13 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.010 & 0.00949668 & uM & 0.01 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M18 & trt\\_cp & HA1E & M18 & REP.B007\\_HA1E\\_24H\\_X1\\_B24 & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M18 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.080 & 0.08547010 & uM & 0.08 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M16 & trt\\_cp & HA1E & M16 & REP.B007\\_HA1E\\_24H\\_X1\\_B24 & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M16 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b22 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M13 & trt\\_cp & HA1E & M13 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22 & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M13\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M13\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M13 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b22 & 0.370 & 0.37037000 & uM & 0.37 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M16 & trt\\_cp & HA1E & M16 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22 & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M16\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M16 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b22 & 1.110 & 1.11111000 & uM & 1.11 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M15 & trt\\_cp & HA1E & M15 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22 & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M15\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M15\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M15 & NA & REP & ARP-101 & 0\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b22 & 3.330 & 3.33333000 & uM & 3.33 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M14 & trt\\_cp & HA1E & M14 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22 & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M14\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M14\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M14 & NA & REP & ARP-101 & 1\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & b24 & 0.740 & 0.76923100 & uM & 0.74 uM & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M14 & trt\\_cp & HA1E & M14 & REP.B007\\_HA1E\\_24H\\_X1\\_B24 & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M14 & NA & REP & ARP-101 & 0\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & b13 & 3.330 & 3.33000000 & uM & 3.33 uM & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:3.33 & trt\\_cp & HA1E & N20 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13 & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N20\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N20\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N20 & NA & PCLB & AVA & 0\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & b13 & 0.370 & 0.37000000 & uM & 0.37 uM & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:0.37 & trt\\_cp & HA1E & N22 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13 & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N22\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N22\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N22 & NA & PCLB & AVA & 0\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & b13 & 1.110 & 1.11000000 & uM & 1.11 uM & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:1.11 & trt\\_cp & HA1E & N21 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13 & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N21\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N21\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N21 & NA & PCLB & AVA & 0\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & b13 & 0.040 & 0.04000000 & uM & 0.04 uM & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:0.04 & trt\\_cp & HA1E & N24 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13 & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N24\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N24\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N24 & NA & PCLB & AVA & 0\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & b13 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:10 & trt\\_cp & HA1E & N19 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13 & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N19\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N19\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N19 & NA & PCLB & AVA & 1\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & b13 & 0.120 & 0.12000000 & uM & 0.12 uM & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:0.12 & trt\\_cp & HA1E & N23 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13 & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N23\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N23\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N23 & NA & PCLB & AVA & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & f1b3 & 0.370 & 0.35000000 & uM & 0.37 uM & 24 h & 24 & h & HA1E & ⋯ & CPC006\\_HA1E\\_24H:N13 & trt\\_cp & HA1E & N13 & CPC006\\_HA1E\\_24H\\_X1.A2\\_F1B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO & CPC006\\_HA1E\\_24H\\_X1.A2\\_F1B3\\_DUO52HI53LO:N13\\textbar{}CPC006\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO:N13\\textbar{}CPC006\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO:N13 & NA & CPC & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & CPC007\\_HA1E\\_24H:BRD-K05402890-001-09-2:10 & trt\\_cp & HA1E & H03 & CPC007\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO & CPC007\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO:H03 & NA & CPC & BRD-K05402890 & 1\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC007\\_HA1E\\_6H:BRD-K05402890-001-09-2:10 & trt\\_cp & HA1E & H03 & CPC007\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO & CPC007\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:H03 & NA & CPC & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b21 & 0.370 & 0.37037000 & uM & 0.37 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L04 & trt\\_cp & HA1E & L04 & PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21 & PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L04\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L04 & NA & PBIOA & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b21 & 0.125 & 0.12345700 & uM & 0.125 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L05 & trt\\_cp & HA1E & L05 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L05\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L05\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L05 & NA & PBIOA & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b21 & 3.330 & 3.33333000 & uM & 3.33 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L02 & trt\\_cp & HA1E & L02 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L02\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L02\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L02 & NA & PBIOA & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b21 & 1.110 & 1.11111000 & uM & 1.11 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L03 & trt\\_cp & HA1E & L03 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L03\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L03\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L03 & NA & PBIOA & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b21 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L01 & trt\\_cp & HA1E & L01 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L01\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L01\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L01 & NA & PBIOA & BRD-K05402890 & 0\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & b21 & 0.040 & 0.04115230 & uM & 0.04 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L06 & trt\\_cp & HA1E & L06 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L06\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L06\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L06 & NA & PBIOA & BRD-K05402890 & 0\\\\\n",
"\t R-59022\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC005\\_HA1E\\_6H:BRD-K54665485-001-04-6:10 & trt\\_cp & HA1E & P15 & CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO & CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:P15 & NA & CPC & R-59022 & 0\\\\\n",
"\t ST-638\\_\\_HA1E\\_\\_trt\\_cp & b3 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CPC005\\_HA1E\\_6H:BRD-K51476772-001-01-9:10 & trt\\_cp & HA1E & D03 & CPC005\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO & CPC005\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:D03\\textbar{}CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:D03 & NA & CPC & ST-638 & 0\\\\\n",
"\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp & f1b7 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CRCGN004\\_HA1E\\_6H:BRD-K88145757-001-01-6:10 & trt\\_cp & HA1E & H15\\textbar{}I13\\textbar{}L18 & CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO & CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO:H15\\textbar{}CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO:I13\\textbar{}CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO:L18 & NA & CRCGN & tributyltin & 0\\\\\n",
"\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp & f1b4 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & CRCGN001\\_HA1E\\_24H:BRD-K88145757-001-01-6:10 & trt\\_cp & HA1E & H15\\textbar{}I13 & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:H15\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:I13 & NA & CRCGN & tributyltin & 1\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & f1b7 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & CRCGN004\\_HA1E\\_24H:BRD-K78683072-001-01-6:10 & trt\\_cp & HA1E & D19\\textbar{}F18\\textbar{}G07 & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:G07 & NA & CRCGN & triphenyl-tin & 0\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & f1b7 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & CRCGN004\\_HA1E\\_24H:BRD-K78683072-001-01-6:10UM & trt\\_cp & HA1E & D19\\textbar{}F18\\textbar{}G07 & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:G07 & NA & CRCGN & triphenyl-tin & 0\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & f1b4 & 10.000 & 10.00000000 & uM & 10 uM & 6 h & 6 & h & HA1E & ⋯ & CRCGN001\\_HA1E\\_6H:BRD-K78683072-001-01-6:10 & trt\\_cp & HA1E & D19\\textbar{}F18\\textbar{}G07 & CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO & CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO:G07 & NA & CRCGN & triphenyl-tin & 0\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & f1b4 & 10.000 & 10.00000000 & uM & 10 uM & 24 h & 24 & h & HA1E & ⋯ & CRCGN001\\_HA1E\\_24H:BRD-K78683072-001-01-6:10 & trt\\_cp & HA1E & D14\\textbar{}D19\\textbar{}F18\\textbar{}G07\\textbar{}K11 & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:D14\\textbar{}CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:K11\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:D14\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:G07 & NA & CRCGN & triphenyl-tin & 0\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 52 × 36\n",
"\n",
"| .id <chr> | bead_batch <chr> | nearest_dose <dbl> | pert_dose <dbl> | pert_dose_unit <chr> | pert_idose <chr> | pert_itime <chr> | pert_time <dbl> | pert_time_unit <chr> | cell_mfc_name <chr> | ⋯ ⋯ | sig_id <chr> | pert_type <chr> | cell_iname <chr> | det_wells <chr> | det_plates <chr> | distil_ids <chr> | build_name <lgl> | project_code <chr> | cmap_name <chr> | is_ncs_exemplar <int> |\n",
"|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
"| aminomethyltransferase__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | CPC001_HA1E_24H:BRD-A28318179-003-03-6:10 | trt_cp | HA1E | J07 | CPC001_HA1E_24H_X1_B3_DUO52HI53LO|CPC001_HA1E_24H_X2_B3_DUO52HI53LO|CPC001_HA1E_24H_X3_B3_DUO52HI53LO | CPC001_HA1E_24H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X3_B3_DUO52HI53LO:J07 | NA | CPC | aminomethyltransferase | 0 |\n",
"| aminomethyltransferase__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC001_HA1E_6H:BRD-A28318179-003-03-6:10 | trt_cp | HA1E | J07 | CPC001_HA1E_6H_X1_B3_DUO52HI53LO|CPC001_HA1E_6H_X2_B3_DUO52HI53LO|CPC001_HA1E_6H_X3_B3_DUO52HI53LO | CPC001_HA1E_6H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X3_B3_DUO52HI53LO:J07 | NA | CPC | aminomethyltransferase | 1 |\n",
"| anagrelide__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC004_HA1E_6H:BRD-K62200014-003-05-5:10 | trt_cp | HA1E | L03 | CPC004_HA1E_6H_X1_B3_DUO52HI53LO|CPC004_HA1E_6H_X2_B3_DUO52HI53LO|CPC004_HA1E_6H_X3_B3_DUO52HI53LO | CPC004_HA1E_6H_X1_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X2_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X3_B3_DUO52HI53LO:L03 | NA | CPC | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | f1b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC011_HA1E_6H:BRD-K62200014-003-07-1:10 | trt_cp | HA1E | H10 | CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO | CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO:H10|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO:H10 | NA | CPC | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b23 | 0.740 | 0.76923100 | uM | 0.74 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B14 | trt_cp | HA1E | B14 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 | REP.B018_HA1E_24H_X1_B23:B14|REP.B018_HA1E_24H_X2_B23:B14 | NA | REP | anagrelide | 1 |\n",
"| anagrelide__HA1E__trt_cp | b24 | 1.110 | 1.11111000 | uM | 1.11 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B15 | trt_cp | HA1E | B15 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 | REP.A018_HA1E_24H_X1_B24:B15|REP.A018_HA1E_24H_X2_B23:B15|REP.A018_HA1E_24H_X3_B23:B15 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b24 | 0.040 | 0.04115230 | uM | 0.04 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B18 | trt_cp | HA1E | B18 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 | REP.A018_HA1E_24H_X1_B24:B18|REP.A018_HA1E_24H_X2_B23:B18|REP.A018_HA1E_24H_X3_B23:B18 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b23 | 0.080 | 0.08547010 | uM | 0.08 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B16 | trt_cp | HA1E | B16 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 | REP.B018_HA1E_24H_X1_B23:B16|REP.B018_HA1E_24H_X2_B23:B16 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b24 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B13 | trt_cp | HA1E | B13 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 | REP.A018_HA1E_24H_X1_B24:B13|REP.A018_HA1E_24H_X2_B23:B13|REP.A018_HA1E_24H_X3_B23:B13 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b23 | 0.250 | 0.25641000 | uM | 0.25 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B15 | trt_cp | HA1E | B15 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 | REP.B018_HA1E_24H_X1_B23:B15|REP.B018_HA1E_24H_X2_B23:B15 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b24 | 0.125 | 0.12345700 | uM | 0.125 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B17 | trt_cp | HA1E | B17 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 | REP.A018_HA1E_24H_X1_B24:B17|REP.A018_HA1E_24H_X2_B23:B17|REP.A018_HA1E_24H_X3_B23:B17 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b23 | 0.010 | 0.00949668 | uM | 0.01 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B18 | trt_cp | HA1E | B18 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 | REP.B018_HA1E_24H_X1_B23:B18|REP.B018_HA1E_24H_X2_B23:B18 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b24 | 0.370 | 0.37037000 | uM | 0.37 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B16 | trt_cp | HA1E | B16 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 | REP.A018_HA1E_24H_X1_B24:B16|REP.A018_HA1E_24H_X2_B23:B16|REP.A018_HA1E_24H_X3_B23:B16 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b24 | 3.330 | 3.33333000 | uM | 3.33 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B14 | trt_cp | HA1E | B14 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 | REP.A018_HA1E_24H_X1_B24:B14|REP.A018_HA1E_24H_X2_B23:B14|REP.A018_HA1E_24H_X3_B23:B14 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b23 | 2.220 | 2.30769000 | uM | 2.22 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B13 | trt_cp | HA1E | B13 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 | REP.B018_HA1E_24H_X1_B23:B13|REP.B018_HA1E_24H_X2_B23:B13 | NA | REP | anagrelide | 0 |\n",
"| anagrelide__HA1E__trt_cp | b23 | 0.030 | 0.02849000 | uM | 0.03 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B17 | trt_cp | HA1E | B17 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 | REP.B018_HA1E_24H_X1_B23:B17|REP.B018_HA1E_24H_X2_B23:B17 | NA | REP | anagrelide | 0 |\n",
"| ARP-101__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC006_HA1E_6H:BRD-K73395020-001-01-5:10 | trt_cp | HA1E | K04 | CPC006_HA1E_6H_X1_B3_DUO52HI53LO|CPC006_HA1E_6H_X2_B3_DUO52HI53LO|CPC006_HA1E_6H_X3_B3_DUO52HI53LO|CPC006_HA1E_6H_X4_B4_DUO52HI53LO|CPC006_HA1E_6H_X5_B4_DUO52HI53LO | CPC006_HA1E_6H_X1_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X2_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X3_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X4_B4_DUO52HI53LO:K04|CPC006_HA1E_6H_X5_B4_DUO52HI53LO:K04 | NA | CPC | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b24 | 0.030 | 0.02849000 | uM | 0.03 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M17 | trt_cp | HA1E | M17 | REP.B007_HA1E_24H_X1_B24 | REP.B007_HA1E_24H_X1_B24:M17 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b22 | 0.040 | 0.04115230 | uM | 0.04 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M18 | trt_cp | HA1E | M18 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 | REP.A007_HA1E_24H_X1_B22:M18|REP.A007_HA1E_24H_X2_B24:M18|REP.A007_HA1E_24H_X3_B22:M18 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b24 | 0.250 | 0.25641000 | uM | 0.25 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M15 | trt_cp | HA1E | M15 | REP.B007_HA1E_24H_X1_B24 | REP.B007_HA1E_24H_X1_B24:M15 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b22 | 0.125 | 0.12345700 | uM | 0.125 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M17 | trt_cp | HA1E | M17 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 | REP.A007_HA1E_24H_X1_B22:M17|REP.A007_HA1E_24H_X2_B24:M17|REP.A007_HA1E_24H_X3_B22:M17 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b24 | 2.220 | 2.30769000 | uM | 2.22 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M13 | trt_cp | HA1E | M13 | REP.B007_HA1E_24H_X1_B24 | REP.B007_HA1E_24H_X1_B24:M13 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b24 | 0.010 | 0.00949668 | uM | 0.01 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M18 | trt_cp | HA1E | M18 | REP.B007_HA1E_24H_X1_B24 | REP.B007_HA1E_24H_X1_B24:M18 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b24 | 0.080 | 0.08547010 | uM | 0.08 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M16 | trt_cp | HA1E | M16 | REP.B007_HA1E_24H_X1_B24 | REP.B007_HA1E_24H_X1_B24:M16 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b22 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M13 | trt_cp | HA1E | M13 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 | REP.A007_HA1E_24H_X1_B22:M13|REP.A007_HA1E_24H_X2_B24:M13|REP.A007_HA1E_24H_X3_B22:M13 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b22 | 0.370 | 0.37037000 | uM | 0.37 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M16 | trt_cp | HA1E | M16 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X3_B22 | REP.A007_HA1E_24H_X1_B22:M16|REP.A007_HA1E_24H_X3_B22:M16 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b22 | 1.110 | 1.11111000 | uM | 1.11 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M15 | trt_cp | HA1E | M15 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 | REP.A007_HA1E_24H_X1_B22:M15|REP.A007_HA1E_24H_X2_B24:M15|REP.A007_HA1E_24H_X3_B22:M15 | NA | REP | ARP-101 | 0 |\n",
"| ARP-101__HA1E__trt_cp | b22 | 3.330 | 3.33333000 | uM | 3.33 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M14 | trt_cp | HA1E | M14 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 | REP.A007_HA1E_24H_X1_B22:M14|REP.A007_HA1E_24H_X2_B24:M14|REP.A007_HA1E_24H_X3_B22:M14 | NA | REP | ARP-101 | 1 |\n",
"| ARP-101__HA1E__trt_cp | b24 | 0.740 | 0.76923100 | uM | 0.74 uM | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M14 | trt_cp | HA1E | M14 | REP.B007_HA1E_24H_X1_B24 | REP.B007_HA1E_24H_X1_B24:M14 | NA | REP | ARP-101 | 0 |\n",
"| AVA__HA1E__trt_cp | b13 | 3.330 | 3.33000000 | uM | 3.33 uM | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:3.33 | trt_cp | HA1E | N20 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 | PCLB003_HA1E_24H_X1_B13:N20|PCLB003_HA1E_24H_X2_B13:N20|PCLB003_HA1E_24H_X3_B13:N20 | NA | PCLB | AVA | 0 |\n",
"| AVA__HA1E__trt_cp | b13 | 0.370 | 0.37000000 | uM | 0.37 uM | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.37 | trt_cp | HA1E | N22 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 | PCLB003_HA1E_24H_X1_B13:N22|PCLB003_HA1E_24H_X2_B13:N22|PCLB003_HA1E_24H_X3_B13:N22 | NA | PCLB | AVA | 0 |\n",
"| AVA__HA1E__trt_cp | b13 | 1.110 | 1.11000000 | uM | 1.11 uM | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:1.11 | trt_cp | HA1E | N21 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 | PCLB003_HA1E_24H_X1_B13:N21|PCLB003_HA1E_24H_X2_B13:N21|PCLB003_HA1E_24H_X3_B13:N21 | NA | PCLB | AVA | 0 |\n",
"| AVA__HA1E__trt_cp | b13 | 0.040 | 0.04000000 | uM | 0.04 uM | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.04 | trt_cp | HA1E | N24 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 | PCLB003_HA1E_24H_X1_B13:N24|PCLB003_HA1E_24H_X2_B13:N24|PCLB003_HA1E_24H_X3_B13:N24 | NA | PCLB | AVA | 0 |\n",
"| AVA__HA1E__trt_cp | b13 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:10 | trt_cp | HA1E | N19 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 | PCLB003_HA1E_24H_X1_B13:N19|PCLB003_HA1E_24H_X2_B13:N19|PCLB003_HA1E_24H_X3_B13:N19 | NA | PCLB | AVA | 1 |\n",
"| AVA__HA1E__trt_cp | b13 | 0.120 | 0.12000000 | uM | 0.12 uM | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.12 | trt_cp | HA1E | N23 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 | PCLB003_HA1E_24H_X1_B13:N23|PCLB003_HA1E_24H_X2_B13:N23|PCLB003_HA1E_24H_X3_B13:N23 | NA | PCLB | AVA | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | f1b3 | 0.370 | 0.35000000 | uM | 0.37 uM | 24 h | 24 | h | HA1E | ⋯ | CPC006_HA1E_24H:N13 | trt_cp | HA1E | N13 | CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO|CPC006_HA1E_24H_X2_B3_DUO52HI53LO|CPC006_HA1E_24H_X3_B3_DUO52HI53LO | CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X2_B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X3_B3_DUO52HI53LO:N13 | NA | CPC | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | CPC007_HA1E_24H:BRD-K05402890-001-09-2:10 | trt_cp | HA1E | H03 | CPC007_HA1E_24H_X1_B3_DUO52HI53LO|CPC007_HA1E_24H_X2_B3_DUO52HI53LO|CPC007_HA1E_24H_X3_B3_DUO52HI53LO | CPC007_HA1E_24H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X3_B3_DUO52HI53LO:H03 | NA | CPC | BRD-K05402890 | 1 |\n",
"| BRD-K05402890__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC007_HA1E_6H:BRD-K05402890-001-09-2:10 | trt_cp | HA1E | H03 | CPC007_HA1E_6H_X1_B3_DUO52HI53LO|CPC007_HA1E_6H_X2_B3_DUO52HI53LO|CPC007_HA1E_6H_X3_B3_DUO52HI53LO | CPC007_HA1E_6H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X3_B3_DUO52HI53LO:H03 | NA | CPC | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b21 | 0.370 | 0.37037000 | uM | 0.37 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L04 | trt_cp | HA1E | L04 | PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 | PBIOA014_HA1E_24H_X2_B21:L04|PBIOA014_HA1E_24H_X3_B21:L04 | NA | PBIOA | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b21 | 0.125 | 0.12345700 | uM | 0.125 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L05 | trt_cp | HA1E | L05 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 | PBIOA014_HA1E_24H_X1_B21:L05|PBIOA014_HA1E_24H_X2_B21:L05|PBIOA014_HA1E_24H_X3_B21:L05 | NA | PBIOA | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b21 | 3.330 | 3.33333000 | uM | 3.33 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L02 | trt_cp | HA1E | L02 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 | PBIOA014_HA1E_24H_X1_B21:L02|PBIOA014_HA1E_24H_X2_B21:L02|PBIOA014_HA1E_24H_X3_B21:L02 | NA | PBIOA | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b21 | 1.110 | 1.11111000 | uM | 1.11 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L03 | trt_cp | HA1E | L03 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 | PBIOA014_HA1E_24H_X1_B21:L03|PBIOA014_HA1E_24H_X2_B21:L03|PBIOA014_HA1E_24H_X3_B21:L03 | NA | PBIOA | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b21 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L01 | trt_cp | HA1E | L01 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 | PBIOA014_HA1E_24H_X1_B21:L01|PBIOA014_HA1E_24H_X2_B21:L01|PBIOA014_HA1E_24H_X3_B21:L01 | NA | PBIOA | BRD-K05402890 | 0 |\n",
"| BRD-K05402890__HA1E__trt_cp | b21 | 0.040 | 0.04115230 | uM | 0.04 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L06 | trt_cp | HA1E | L06 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 | PBIOA014_HA1E_24H_X1_B21:L06|PBIOA014_HA1E_24H_X2_B21:L06|PBIOA014_HA1E_24H_X3_B21:L06 | NA | PBIOA | BRD-K05402890 | 0 |\n",
"| R-59022__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC005_HA1E_6H:BRD-K54665485-001-04-6:10 | trt_cp | HA1E | P15 | CPC005_HA1E_6H_X3_B3_DUO52HI53LO | CPC005_HA1E_6H_X3_B3_DUO52HI53LO:P15 | NA | CPC | R-59022 | 0 |\n",
"| ST-638__HA1E__trt_cp | b3 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CPC005_HA1E_6H:BRD-K51476772-001-01-9:10 | trt_cp | HA1E | D03 | CPC005_HA1E_6H_X1_B3_DUO52HI53LO|CPC005_HA1E_6H_X3_B3_DUO52HI53LO | CPC005_HA1E_6H_X1_B3_DUO52HI53LO:D03|CPC005_HA1E_6H_X3_B3_DUO52HI53LO:D03 | NA | CPC | ST-638 | 0 |\n",
"| tributyltin__HA1E__trt_cp | f1b7 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CRCGN004_HA1E_6H:BRD-K88145757-001-01-6:10 | trt_cp | HA1E | H15|I13|L18 | CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO | CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:H15|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:I13|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:L18 | NA | CRCGN | tributyltin | 0 |\n",
"| tributyltin__HA1E__trt_cp | f1b4 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | CRCGN001_HA1E_24H:BRD-K88145757-001-01-6:10 | trt_cp | HA1E | H15|I13 | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:H15|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:I13 | NA | CRCGN | tributyltin | 1 |\n",
"| triphenyl-tin__HA1E__trt_cp | f1b7 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10 | trt_cp | HA1E | D19|F18|G07 | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07 | NA | CRCGN | triphenyl-tin | 0 |\n",
"| triphenyl-tin__HA1E__trt_cp | f1b7 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10UM | trt_cp | HA1E | D19|F18|G07 | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07 | NA | CRCGN | triphenyl-tin | 0 |\n",
"| triphenyl-tin__HA1E__trt_cp | f1b4 | 10.000 | 10.00000000 | uM | 10 uM | 6 h | 6 | h | HA1E | ⋯ | CRCGN001_HA1E_6H:BRD-K78683072-001-01-6:10 | trt_cp | HA1E | D19|F18|G07 | CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO | CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:G07 | NA | CRCGN | triphenyl-tin | 0 |\n",
"| triphenyl-tin__HA1E__trt_cp | f1b4 | 10.000 | 10.00000000 | uM | 10 uM | 24 h | 24 | h | HA1E | ⋯ | CRCGN001_HA1E_24H:BRD-K78683072-001-01-6:10 | trt_cp | HA1E | D14|D19|F18|G07|K11 | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:K11|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:G07 | NA | CRCGN | triphenyl-tin | 0 |\n",
"\n"
],
"text/plain": [
" .id bead_batch nearest_dose pert_dose \n",
"1 aminomethyltransferase__HA1E__trt_cp b3 10.000 10.00000000\n",
"2 aminomethyltransferase__HA1E__trt_cp b3 10.000 10.00000000\n",
"3 anagrelide__HA1E__trt_cp b3 10.000 10.00000000\n",
"4 anagrelide__HA1E__trt_cp f1b3 10.000 10.00000000\n",
"5 anagrelide__HA1E__trt_cp b23 0.740 0.76923100\n",
"6 anagrelide__HA1E__trt_cp b24 1.110 1.11111000\n",
"7 anagrelide__HA1E__trt_cp b24 0.040 0.04115230\n",
"8 anagrelide__HA1E__trt_cp b23 0.080 0.08547010\n",
"9 anagrelide__HA1E__trt_cp b24 10.000 10.00000000\n",
"10 anagrelide__HA1E__trt_cp b23 0.250 0.25641000\n",
"11 anagrelide__HA1E__trt_cp b24 0.125 0.12345700\n",
"12 anagrelide__HA1E__trt_cp b23 0.010 0.00949668\n",
"13 anagrelide__HA1E__trt_cp b24 0.370 0.37037000\n",
"14 anagrelide__HA1E__trt_cp b24 3.330 3.33333000\n",
"15 anagrelide__HA1E__trt_cp b23 2.220 2.30769000\n",
"16 anagrelide__HA1E__trt_cp b23 0.030 0.02849000\n",
"17 ARP-101__HA1E__trt_cp b3 10.000 10.00000000\n",
"18 ARP-101__HA1E__trt_cp b24 0.030 0.02849000\n",
"19 ARP-101__HA1E__trt_cp b22 0.040 0.04115230\n",
"20 ARP-101__HA1E__trt_cp b24 0.250 0.25641000\n",
"21 ARP-101__HA1E__trt_cp b22 0.125 0.12345700\n",
"22 ARP-101__HA1E__trt_cp b24 2.220 2.30769000\n",
"23 ARP-101__HA1E__trt_cp b24 0.010 0.00949668\n",
"24 ARP-101__HA1E__trt_cp b24 0.080 0.08547010\n",
"25 ARP-101__HA1E__trt_cp b22 10.000 10.00000000\n",
"26 ARP-101__HA1E__trt_cp b22 0.370 0.37037000\n",
"27 ARP-101__HA1E__trt_cp b22 1.110 1.11111000\n",
"28 ARP-101__HA1E__trt_cp b22 3.330 3.33333000\n",
"29 ARP-101__HA1E__trt_cp b24 0.740 0.76923100\n",
"30 AVA__HA1E__trt_cp b13 3.330 3.33000000\n",
"31 AVA__HA1E__trt_cp b13 0.370 0.37000000\n",
"32 AVA__HA1E__trt_cp b13 1.110 1.11000000\n",
"33 AVA__HA1E__trt_cp b13 0.040 0.04000000\n",
"34 AVA__HA1E__trt_cp b13 10.000 10.00000000\n",
"35 AVA__HA1E__trt_cp b13 0.120 0.12000000\n",
"36 BRD-K05402890__HA1E__trt_cp f1b3 0.370 0.35000000\n",
"37 BRD-K05402890__HA1E__trt_cp b3 10.000 10.00000000\n",
"38 BRD-K05402890__HA1E__trt_cp b3 10.000 10.00000000\n",
"39 BRD-K05402890__HA1E__trt_cp b21 0.370 0.37037000\n",
"40 BRD-K05402890__HA1E__trt_cp b21 0.125 0.12345700\n",
"41 BRD-K05402890__HA1E__trt_cp b21 3.330 3.33333000\n",
"42 BRD-K05402890__HA1E__trt_cp b21 1.110 1.11111000\n",
"43 BRD-K05402890__HA1E__trt_cp b21 10.000 10.00000000\n",
"44 BRD-K05402890__HA1E__trt_cp b21 0.040 0.04115230\n",
"45 R-59022__HA1E__trt_cp b3 10.000 10.00000000\n",
"46 ST-638__HA1E__trt_cp b3 10.000 10.00000000\n",
"47 tributyltin__HA1E__trt_cp f1b7 10.000 10.00000000\n",
"48 tributyltin__HA1E__trt_cp f1b4 10.000 10.00000000\n",
"49 triphenyl-tin__HA1E__trt_cp f1b7 10.000 10.00000000\n",
"50 triphenyl-tin__HA1E__trt_cp f1b7 10.000 10.00000000\n",
"51 triphenyl-tin__HA1E__trt_cp f1b4 10.000 10.00000000\n",
"52 triphenyl-tin__HA1E__trt_cp f1b4 10.000 10.00000000\n",
" pert_dose_unit pert_idose pert_itime pert_time pert_time_unit cell_mfc_name\n",
"1 uM 10 uM 24 h 24 h HA1E \n",
"2 uM 10 uM 6 h 6 h HA1E \n",
"3 uM 10 uM 6 h 6 h HA1E \n",
"4 uM 10 uM 6 h 6 h HA1E \n",
"5 uM 0.74 uM 24 h 24 h HA1E \n",
"6 uM 1.11 uM 24 h 24 h HA1E \n",
"7 uM 0.04 uM 24 h 24 h HA1E \n",
"8 uM 0.08 uM 24 h 24 h HA1E \n",
"9 uM 10 uM 24 h 24 h HA1E \n",
"10 uM 0.25 uM 24 h 24 h HA1E \n",
"11 uM 0.125 uM 24 h 24 h HA1E \n",
"12 uM 0.01 uM 24 h 24 h HA1E \n",
"13 uM 0.37 uM 24 h 24 h HA1E \n",
"14 uM 3.33 uM 24 h 24 h HA1E \n",
"15 uM 2.22 uM 24 h 24 h HA1E \n",
"16 uM 0.03 uM 24 h 24 h HA1E \n",
"17 uM 10 uM 6 h 6 h HA1E \n",
"18 uM 0.03 uM 24 h 24 h HA1E \n",
"19 uM 0.04 uM 24 h 24 h HA1E \n",
"20 uM 0.25 uM 24 h 24 h HA1E \n",
"21 uM 0.125 uM 24 h 24 h HA1E \n",
"22 uM 2.22 uM 24 h 24 h HA1E \n",
"23 uM 0.01 uM 24 h 24 h HA1E \n",
"24 uM 0.08 uM 24 h 24 h HA1E \n",
"25 uM 10 uM 24 h 24 h HA1E \n",
"26 uM 0.37 uM 24 h 24 h HA1E \n",
"27 uM 1.11 uM 24 h 24 h HA1E \n",
"28 uM 3.33 uM 24 h 24 h HA1E \n",
"29 uM 0.74 uM 24 h 24 h HA1E \n",
"30 uM 3.33 uM 24 h 24 h HA1E \n",
"31 uM 0.37 uM 24 h 24 h HA1E \n",
"32 uM 1.11 uM 24 h 24 h HA1E \n",
"33 uM 0.04 uM 24 h 24 h HA1E \n",
"34 uM 10 uM 24 h 24 h HA1E \n",
"35 uM 0.12 uM 24 h 24 h HA1E \n",
"36 uM 0.37 uM 24 h 24 h HA1E \n",
"37 uM 10 uM 24 h 24 h HA1E \n",
"38 uM 10 uM 6 h 6 h HA1E \n",
"39 uM 0.37 uM 24 h 24 h HA1E \n",
"40 uM 0.125 uM 24 h 24 h HA1E \n",
"41 uM 3.33 uM 24 h 24 h HA1E \n",
"42 uM 1.11 uM 24 h 24 h HA1E \n",
"43 uM 10 uM 24 h 24 h HA1E \n",
"44 uM 0.04 uM 24 h 24 h HA1E \n",
"45 uM 10 uM 6 h 6 h HA1E \n",
"46 uM 10 uM 6 h 6 h HA1E \n",
"47 uM 10 uM 6 h 6 h HA1E \n",
"48 uM 10 uM 24 h 24 h HA1E \n",
"49 uM 10 uM 24 h 24 h HA1E \n",
"50 uM 10 uM 24 h 24 h HA1E \n",
"51 uM 10 uM 6 h 6 h HA1E \n",
"52 uM 10 uM 24 h 24 h HA1E \n",
" ⋯ sig_id pert_type cell_iname\n",
"1 ⋯ CPC001_HA1E_24H:BRD-A28318179-003-03-6:10 trt_cp HA1E \n",
"2 ⋯ CPC001_HA1E_6H:BRD-A28318179-003-03-6:10 trt_cp HA1E \n",
"3 ⋯ CPC004_HA1E_6H:BRD-K62200014-003-05-5:10 trt_cp HA1E \n",
"4 ⋯ CPC011_HA1E_6H:BRD-K62200014-003-07-1:10 trt_cp HA1E \n",
"5 ⋯ REP.B018_HA1E_24H:B14 trt_cp HA1E \n",
"6 ⋯ REP.A018_HA1E_24H:B15 trt_cp HA1E \n",
"7 ⋯ REP.A018_HA1E_24H:B18 trt_cp HA1E \n",
"8 ⋯ REP.B018_HA1E_24H:B16 trt_cp HA1E \n",
"9 ⋯ REP.A018_HA1E_24H:B13 trt_cp HA1E \n",
"10 ⋯ REP.B018_HA1E_24H:B15 trt_cp HA1E \n",
"11 ⋯ REP.A018_HA1E_24H:B17 trt_cp HA1E \n",
"12 ⋯ REP.B018_HA1E_24H:B18 trt_cp HA1E \n",
"13 ⋯ REP.A018_HA1E_24H:B16 trt_cp HA1E \n",
"14 ⋯ REP.A018_HA1E_24H:B14 trt_cp HA1E \n",
"15 ⋯ REP.B018_HA1E_24H:B13 trt_cp HA1E \n",
"16 ⋯ REP.B018_HA1E_24H:B17 trt_cp HA1E \n",
"17 ⋯ CPC006_HA1E_6H:BRD-K73395020-001-01-5:10 trt_cp HA1E \n",
"18 ⋯ REP.B007_HA1E_24H:M17 trt_cp HA1E \n",
"19 ⋯ REP.A007_HA1E_24H:M18 trt_cp HA1E \n",
"20 ⋯ REP.B007_HA1E_24H:M15 trt_cp HA1E \n",
"21 ⋯ REP.A007_HA1E_24H:M17 trt_cp HA1E \n",
"22 ⋯ REP.B007_HA1E_24H:M13 trt_cp HA1E \n",
"23 ⋯ REP.B007_HA1E_24H:M18 trt_cp HA1E \n",
"24 ⋯ REP.B007_HA1E_24H:M16 trt_cp HA1E \n",
"25 ⋯ REP.A007_HA1E_24H:M13 trt_cp HA1E \n",
"26 ⋯ REP.A007_HA1E_24H:M16 trt_cp HA1E \n",
"27 ⋯ REP.A007_HA1E_24H:M15 trt_cp HA1E \n",
"28 ⋯ REP.A007_HA1E_24H:M14 trt_cp HA1E \n",
"29 ⋯ REP.B007_HA1E_24H:M14 trt_cp HA1E \n",
"30 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:3.33 trt_cp HA1E \n",
"31 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.37 trt_cp HA1E \n",
"32 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:1.11 trt_cp HA1E \n",
"33 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.04 trt_cp HA1E \n",
"34 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:10 trt_cp HA1E \n",
"35 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.12 trt_cp HA1E \n",
"36 ⋯ CPC006_HA1E_24H:N13 trt_cp HA1E \n",
"37 ⋯ CPC007_HA1E_24H:BRD-K05402890-001-09-2:10 trt_cp HA1E \n",
"38 ⋯ CPC007_HA1E_6H:BRD-K05402890-001-09-2:10 trt_cp HA1E \n",
"39 ⋯ PBIOA014_HA1E_24H:L04 trt_cp HA1E \n",
"40 ⋯ PBIOA014_HA1E_24H:L05 trt_cp HA1E \n",
"41 ⋯ PBIOA014_HA1E_24H:L02 trt_cp HA1E \n",
"42 ⋯ PBIOA014_HA1E_24H:L03 trt_cp HA1E \n",
"43 ⋯ PBIOA014_HA1E_24H:L01 trt_cp HA1E \n",
"44 ⋯ PBIOA014_HA1E_24H:L06 trt_cp HA1E \n",
"45 ⋯ CPC005_HA1E_6H:BRD-K54665485-001-04-6:10 trt_cp HA1E \n",
"46 ⋯ CPC005_HA1E_6H:BRD-K51476772-001-01-9:10 trt_cp HA1E \n",
"47 ⋯ CRCGN004_HA1E_6H:BRD-K88145757-001-01-6:10 trt_cp HA1E \n",
"48 ⋯ CRCGN001_HA1E_24H:BRD-K88145757-001-01-6:10 trt_cp HA1E \n",
"49 ⋯ CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10 trt_cp HA1E \n",
"50 ⋯ CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10UM trt_cp HA1E \n",
"51 ⋯ CRCGN001_HA1E_6H:BRD-K78683072-001-01-6:10 trt_cp HA1E \n",
"52 ⋯ CRCGN001_HA1E_24H:BRD-K78683072-001-01-6:10 trt_cp HA1E \n",
" det_wells \n",
"1 J07 \n",
"2 J07 \n",
"3 L03 \n",
"4 H10 \n",
"5 B14 \n",
"6 B15 \n",
"7 B18 \n",
"8 B16 \n",
"9 B13 \n",
"10 B15 \n",
"11 B17 \n",
"12 B18 \n",
"13 B16 \n",
"14 B14 \n",
"15 B13 \n",
"16 B17 \n",
"17 K04 \n",
"18 M17 \n",
"19 M18 \n",
"20 M15 \n",
"21 M17 \n",
"22 M13 \n",
"23 M18 \n",
"24 M16 \n",
"25 M13 \n",
"26 M16 \n",
"27 M15 \n",
"28 M14 \n",
"29 M14 \n",
"30 N20 \n",
"31 N22 \n",
"32 N21 \n",
"33 N24 \n",
"34 N19 \n",
"35 N23 \n",
"36 N13 \n",
"37 H03 \n",
"38 H03 \n",
"39 L04 \n",
"40 L05 \n",
"41 L02 \n",
"42 L03 \n",
"43 L01 \n",
"44 L06 \n",
"45 P15 \n",
"46 D03 \n",
"47 H15|I13|L18 \n",
"48 H15|I13 \n",
"49 D19|F18|G07 \n",
"50 D19|F18|G07 \n",
"51 D19|F18|G07 \n",
"52 D14|D19|F18|G07|K11\n",
" det_plates \n",
"1 CPC001_HA1E_24H_X1_B3_DUO52HI53LO|CPC001_HA1E_24H_X2_B3_DUO52HI53LO|CPC001_HA1E_24H_X3_B3_DUO52HI53LO \n",
"2 CPC001_HA1E_6H_X1_B3_DUO52HI53LO|CPC001_HA1E_6H_X2_B3_DUO52HI53LO|CPC001_HA1E_6H_X3_B3_DUO52HI53LO \n",
"3 CPC004_HA1E_6H_X1_B3_DUO52HI53LO|CPC004_HA1E_6H_X2_B3_DUO52HI53LO|CPC004_HA1E_6H_X3_B3_DUO52HI53LO \n",
"4 CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO \n",
"5 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 \n",
"6 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 \n",
"7 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 \n",
"8 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 \n",
"9 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 \n",
"10 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 \n",
"11 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 \n",
"12 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 \n",
"13 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 \n",
"14 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23 \n",
"15 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 \n",
"16 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23 \n",
"17 CPC006_HA1E_6H_X1_B3_DUO52HI53LO|CPC006_HA1E_6H_X2_B3_DUO52HI53LO|CPC006_HA1E_6H_X3_B3_DUO52HI53LO|CPC006_HA1E_6H_X4_B4_DUO52HI53LO|CPC006_HA1E_6H_X5_B4_DUO52HI53LO\n",
"18 REP.B007_HA1E_24H_X1_B24 \n",
"19 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 \n",
"20 REP.B007_HA1E_24H_X1_B24 \n",
"21 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 \n",
"22 REP.B007_HA1E_24H_X1_B24 \n",
"23 REP.B007_HA1E_24H_X1_B24 \n",
"24 REP.B007_HA1E_24H_X1_B24 \n",
"25 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 \n",
"26 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X3_B22 \n",
"27 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 \n",
"28 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22 \n",
"29 REP.B007_HA1E_24H_X1_B24 \n",
"30 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 \n",
"31 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 \n",
"32 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 \n",
"33 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 \n",
"34 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 \n",
"35 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13 \n",
"36 CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO|CPC006_HA1E_24H_X2_B3_DUO52HI53LO|CPC006_HA1E_24H_X3_B3_DUO52HI53LO \n",
"37 CPC007_HA1E_24H_X1_B3_DUO52HI53LO|CPC007_HA1E_24H_X2_B3_DUO52HI53LO|CPC007_HA1E_24H_X3_B3_DUO52HI53LO \n",
"38 CPC007_HA1E_6H_X1_B3_DUO52HI53LO|CPC007_HA1E_6H_X2_B3_DUO52HI53LO|CPC007_HA1E_6H_X3_B3_DUO52HI53LO \n",
"39 PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 \n",
"40 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 \n",
"41 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 \n",
"42 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 \n",
"43 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 \n",
"44 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21 \n",
"45 CPC005_HA1E_6H_X3_B3_DUO52HI53LO \n",
"46 CPC005_HA1E_6H_X1_B3_DUO52HI53LO|CPC005_HA1E_6H_X3_B3_DUO52HI53LO \n",
"47 CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO \n",
"48 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO \n",
"49 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO \n",
"50 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO \n",
"51 CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO \n",
"52 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO \n",
" distil_ids \n",
"1 CPC001_HA1E_24H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X3_B3_DUO52HI53LO:J07 \n",
"2 CPC001_HA1E_6H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X3_B3_DUO52HI53LO:J07 \n",
"3 CPC004_HA1E_6H_X1_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X2_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X3_B3_DUO52HI53LO:L03 \n",
"4 CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO:H10|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO:H10 \n",
"5 REP.B018_HA1E_24H_X1_B23:B14|REP.B018_HA1E_24H_X2_B23:B14 \n",
"6 REP.A018_HA1E_24H_X1_B24:B15|REP.A018_HA1E_24H_X2_B23:B15|REP.A018_HA1E_24H_X3_B23:B15 \n",
"7 REP.A018_HA1E_24H_X1_B24:B18|REP.A018_HA1E_24H_X2_B23:B18|REP.A018_HA1E_24H_X3_B23:B18 \n",
"8 REP.B018_HA1E_24H_X1_B23:B16|REP.B018_HA1E_24H_X2_B23:B16 \n",
"9 REP.A018_HA1E_24H_X1_B24:B13|REP.A018_HA1E_24H_X2_B23:B13|REP.A018_HA1E_24H_X3_B23:B13 \n",
"10 REP.B018_HA1E_24H_X1_B23:B15|REP.B018_HA1E_24H_X2_B23:B15 \n",
"11 REP.A018_HA1E_24H_X1_B24:B17|REP.A018_HA1E_24H_X2_B23:B17|REP.A018_HA1E_24H_X3_B23:B17 \n",
"12 REP.B018_HA1E_24H_X1_B23:B18|REP.B018_HA1E_24H_X2_B23:B18 \n",
"13 REP.A018_HA1E_24H_X1_B24:B16|REP.A018_HA1E_24H_X2_B23:B16|REP.A018_HA1E_24H_X3_B23:B16 \n",
"14 REP.A018_HA1E_24H_X1_B24:B14|REP.A018_HA1E_24H_X2_B23:B14|REP.A018_HA1E_24H_X3_B23:B14 \n",
"15 REP.B018_HA1E_24H_X1_B23:B13|REP.B018_HA1E_24H_X2_B23:B13 \n",
"16 REP.B018_HA1E_24H_X1_B23:B17|REP.B018_HA1E_24H_X2_B23:B17 \n",
"17 CPC006_HA1E_6H_X1_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X2_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X3_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X4_B4_DUO52HI53LO:K04|CPC006_HA1E_6H_X5_B4_DUO52HI53LO:K04 \n",
"18 REP.B007_HA1E_24H_X1_B24:M17 \n",
"19 REP.A007_HA1E_24H_X1_B22:M18|REP.A007_HA1E_24H_X2_B24:M18|REP.A007_HA1E_24H_X3_B22:M18 \n",
"20 REP.B007_HA1E_24H_X1_B24:M15 \n",
"21 REP.A007_HA1E_24H_X1_B22:M17|REP.A007_HA1E_24H_X2_B24:M17|REP.A007_HA1E_24H_X3_B22:M17 \n",
"22 REP.B007_HA1E_24H_X1_B24:M13 \n",
"23 REP.B007_HA1E_24H_X1_B24:M18 \n",
"24 REP.B007_HA1E_24H_X1_B24:M16 \n",
"25 REP.A007_HA1E_24H_X1_B22:M13|REP.A007_HA1E_24H_X2_B24:M13|REP.A007_HA1E_24H_X3_B22:M13 \n",
"26 REP.A007_HA1E_24H_X1_B22:M16|REP.A007_HA1E_24H_X3_B22:M16 \n",
"27 REP.A007_HA1E_24H_X1_B22:M15|REP.A007_HA1E_24H_X2_B24:M15|REP.A007_HA1E_24H_X3_B22:M15 \n",
"28 REP.A007_HA1E_24H_X1_B22:M14|REP.A007_HA1E_24H_X2_B24:M14|REP.A007_HA1E_24H_X3_B22:M14 \n",
"29 REP.B007_HA1E_24H_X1_B24:M14 \n",
"30 PCLB003_HA1E_24H_X1_B13:N20|PCLB003_HA1E_24H_X2_B13:N20|PCLB003_HA1E_24H_X3_B13:N20 \n",
"31 PCLB003_HA1E_24H_X1_B13:N22|PCLB003_HA1E_24H_X2_B13:N22|PCLB003_HA1E_24H_X3_B13:N22 \n",
"32 PCLB003_HA1E_24H_X1_B13:N21|PCLB003_HA1E_24H_X2_B13:N21|PCLB003_HA1E_24H_X3_B13:N21 \n",
"33 PCLB003_HA1E_24H_X1_B13:N24|PCLB003_HA1E_24H_X2_B13:N24|PCLB003_HA1E_24H_X3_B13:N24 \n",
"34 PCLB003_HA1E_24H_X1_B13:N19|PCLB003_HA1E_24H_X2_B13:N19|PCLB003_HA1E_24H_X3_B13:N19 \n",
"35 PCLB003_HA1E_24H_X1_B13:N23|PCLB003_HA1E_24H_X2_B13:N23|PCLB003_HA1E_24H_X3_B13:N23 \n",
"36 CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X2_B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X3_B3_DUO52HI53LO:N13 \n",
"37 CPC007_HA1E_24H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X3_B3_DUO52HI53LO:H03 \n",
"38 CPC007_HA1E_6H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X3_B3_DUO52HI53LO:H03 \n",
"39 PBIOA014_HA1E_24H_X2_B21:L04|PBIOA014_HA1E_24H_X3_B21:L04 \n",
"40 PBIOA014_HA1E_24H_X1_B21:L05|PBIOA014_HA1E_24H_X2_B21:L05|PBIOA014_HA1E_24H_X3_B21:L05 \n",
"41 PBIOA014_HA1E_24H_X1_B21:L02|PBIOA014_HA1E_24H_X2_B21:L02|PBIOA014_HA1E_24H_X3_B21:L02 \n",
"42 PBIOA014_HA1E_24H_X1_B21:L03|PBIOA014_HA1E_24H_X2_B21:L03|PBIOA014_HA1E_24H_X3_B21:L03 \n",
"43 PBIOA014_HA1E_24H_X1_B21:L01|PBIOA014_HA1E_24H_X2_B21:L01|PBIOA014_HA1E_24H_X3_B21:L01 \n",
"44 PBIOA014_HA1E_24H_X1_B21:L06|PBIOA014_HA1E_24H_X2_B21:L06|PBIOA014_HA1E_24H_X3_B21:L06 \n",
"45 CPC005_HA1E_6H_X3_B3_DUO52HI53LO:P15 \n",
"46 CPC005_HA1E_6H_X1_B3_DUO52HI53LO:D03|CPC005_HA1E_6H_X3_B3_DUO52HI53LO:D03 \n",
"47 CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:H15|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:I13|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:L18 \n",
"48 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:H15|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:I13 \n",
"49 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07 \n",
"50 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07 \n",
"51 CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:G07 \n",
"52 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:K11|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:G07\n",
" build_name project_code cmap_name is_ncs_exemplar\n",
"1 NA CPC aminomethyltransferase 0 \n",
"2 NA CPC aminomethyltransferase 1 \n",
"3 NA CPC anagrelide 0 \n",
"4 NA CPC anagrelide 0 \n",
"5 NA REP anagrelide 1 \n",
"6 NA REP anagrelide 0 \n",
"7 NA REP anagrelide 0 \n",
"8 NA REP anagrelide 0 \n",
"9 NA REP anagrelide 0 \n",
"10 NA REP anagrelide 0 \n",
"11 NA REP anagrelide 0 \n",
"12 NA REP anagrelide 0 \n",
"13 NA REP anagrelide 0 \n",
"14 NA REP anagrelide 0 \n",
"15 NA REP anagrelide 0 \n",
"16 NA REP anagrelide 0 \n",
"17 NA CPC ARP-101 0 \n",
"18 NA REP ARP-101 0 \n",
"19 NA REP ARP-101 0 \n",
"20 NA REP ARP-101 0 \n",
"21 NA REP ARP-101 0 \n",
"22 NA REP ARP-101 0 \n",
"23 NA REP ARP-101 0 \n",
"24 NA REP ARP-101 0 \n",
"25 NA REP ARP-101 0 \n",
"26 NA REP ARP-101 0 \n",
"27 NA REP ARP-101 0 \n",
"28 NA REP ARP-101 1 \n",
"29 NA REP ARP-101 0 \n",
"30 NA PCLB AVA 0 \n",
"31 NA PCLB AVA 0 \n",
"32 NA PCLB AVA 0 \n",
"33 NA PCLB AVA 0 \n",
"34 NA PCLB AVA 1 \n",
"35 NA PCLB AVA 0 \n",
"36 NA CPC BRD-K05402890 0 \n",
"37 NA CPC BRD-K05402890 1 \n",
"38 NA CPC BRD-K05402890 0 \n",
"39 NA PBIOA BRD-K05402890 0 \n",
"40 NA PBIOA BRD-K05402890 0 \n",
"41 NA PBIOA BRD-K05402890 0 \n",
"42 NA PBIOA BRD-K05402890 0 \n",
"43 NA PBIOA BRD-K05402890 0 \n",
"44 NA PBIOA BRD-K05402890 0 \n",
"45 NA CPC R-59022 0 \n",
"46 NA CPC ST-638 0 \n",
"47 NA CRCGN tributyltin 0 \n",
"48 NA CRCGN tributyltin 1 \n",
"49 NA CRCGN triphenyl-tin 0 \n",
"50 NA CRCGN triphenyl-tin 0 \n",
"51 NA CRCGN triphenyl-tin 0 \n",
"52 NA CRCGN triphenyl-tin 0 "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"####extract drug information\n",
"drug.RCC <- as.character(RCC.drug.result$Drug)\n",
"drug.RCC <- sapply(drug.RCC, function(x){\n",
" a <- unlist(strsplit(x, \"__\"))\n",
" return(a[1:2])\n",
"})\n",
"drug.RCC <- unique(t(drug.RCC))\n",
"\n",
"idx <- apply(drug.RCC, 1, function(x){\n",
" index <- which(siginfo_beta$cmap_name == x[1] & siginfo_beta$cell_iname == x[2])\n",
" return(siginfo_beta[index, ])\n",
"})\n",
"drug..RCC.info <- ldply (idx, data.frame)\n",
"write_xlsx(drug..RCC.info, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.drug.info.xlsx\")\n",
"drug..RCC.info"
]
},
{
"cell_type": "code",
"execution_count": 41,
"id": "c9077678-241d-4402-ab30-77ac9c4bd3cc",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:23:26.908720Z",
"iopub.status.busy": "2021-09-23T06:23:26.905235Z",
"iopub.status.idle": "2021-09-23T06:23:26.950160Z",
"shell.execute_reply": "2021-09-23T06:23:26.948785Z"
},
"scrolled": true,
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 11 × 2</caption>\n",
"<thead>\n",
"\t<tr><th></th><th scope=col>Drug</th><th scope=col>mean.Zscore</th></tr>\n",
"\t<tr><th></th><th scope=col><chr></th><th scope=col><dbl></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><th scope=row>triphenyl-tin__HA1E__trt_cp</th><td>triphenyl-tin__HA1E__trt_cp </td><td>-2.005953</td></tr>\n",
"\t<tr><th scope=row>AVA__HA1E__trt_cp</th><td>AVA__HA1E__trt_cp </td><td>-2.028199</td></tr>\n",
"\t<tr><th scope=row>ST-638__HA1E__trt_cp</th><td>ST-638__HA1E__trt_cp </td><td>-2.139165</td></tr>\n",
"\t<tr><th scope=row>BRD-A51929314__HA1E__trt_cp</th><td>BRD-A51929314__HA1E__trt_cp </td><td>-2.227154</td></tr>\n",
"\t<tr><th scope=row>BRD-K05402890__HA1E__trt_cp</th><td>BRD-K05402890__HA1E__trt_cp </td><td>-2.309873</td></tr>\n",
"\t<tr><th scope=row>aminomethyltransferase__HA1E__trt_cp</th><td>aminomethyltransferase__HA1E__trt_cp</td><td>-2.349426</td></tr>\n",
"\t<tr><th scope=row>ARP-101__HA1E__trt_cp</th><td>ARP-101__HA1E__trt_cp </td><td>-2.420850</td></tr>\n",
"\t<tr><th scope=row>R-59022__HA1E__trt_cp</th><td>R-59022__HA1E__trt_cp </td><td>-2.440392</td></tr>\n",
"\t<tr><th scope=row>homoharringtonine__HA1E__trt_cp</th><td>homoharringtonine__HA1E__trt_cp </td><td>-2.545411</td></tr>\n",
"\t<tr><th scope=row>anagrelide__HA1E__trt_cp</th><td>anagrelide__HA1E__trt_cp </td><td>-2.888882</td></tr>\n",
"\t<tr><th scope=row>tributyltin__HA1E__trt_cp</th><td>tributyltin__HA1E__trt_cp </td><td>-3.094550</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 11 × 2\n",
"\\begin{tabular}{r|ll}\n",
" & Drug & mean.Zscore\\\\\n",
" & <chr> & <dbl>\\\\\n",
"\\hline\n",
"\ttriphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & -2.005953\\\\\n",
"\tAVA\\_\\_HA1E\\_\\_trt\\_cp & AVA\\_\\_HA1E\\_\\_trt\\_cp & -2.028199\\\\\n",
"\tST-638\\_\\_HA1E\\_\\_trt\\_cp & ST-638\\_\\_HA1E\\_\\_trt\\_cp & -2.139165\\\\\n",
"\tBRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & -2.227154\\\\\n",
"\tBRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & -2.309873\\\\\n",
"\taminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & -2.349426\\\\\n",
"\tARP-101\\_\\_HA1E\\_\\_trt\\_cp & ARP-101\\_\\_HA1E\\_\\_trt\\_cp & -2.420850\\\\\n",
"\tR-59022\\_\\_HA1E\\_\\_trt\\_cp & R-59022\\_\\_HA1E\\_\\_trt\\_cp & -2.440392\\\\\n",
"\thomoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & -2.545411\\\\\n",
"\tanagrelide\\_\\_HA1E\\_\\_trt\\_cp & anagrelide\\_\\_HA1E\\_\\_trt\\_cp & -2.888882\\\\\n",
"\ttributyltin\\_\\_HA1E\\_\\_trt\\_cp & tributyltin\\_\\_HA1E\\_\\_trt\\_cp & -3.094550\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 11 × 2\n",
"\n",
"| <!--/--> | Drug <chr> | mean.Zscore <dbl> |\n",
"|---|---|---|\n",
"| triphenyl-tin__HA1E__trt_cp | triphenyl-tin__HA1E__trt_cp | -2.005953 |\n",
"| AVA__HA1E__trt_cp | AVA__HA1E__trt_cp | -2.028199 |\n",
"| ST-638__HA1E__trt_cp | ST-638__HA1E__trt_cp | -2.139165 |\n",
"| BRD-A51929314__HA1E__trt_cp | BRD-A51929314__HA1E__trt_cp | -2.227154 |\n",
"| BRD-K05402890__HA1E__trt_cp | BRD-K05402890__HA1E__trt_cp | -2.309873 |\n",
"| aminomethyltransferase__HA1E__trt_cp | aminomethyltransferase__HA1E__trt_cp | -2.349426 |\n",
"| ARP-101__HA1E__trt_cp | ARP-101__HA1E__trt_cp | -2.420850 |\n",
"| R-59022__HA1E__trt_cp | R-59022__HA1E__trt_cp | -2.440392 |\n",
"| homoharringtonine__HA1E__trt_cp | homoharringtonine__HA1E__trt_cp | -2.545411 |\n",
"| anagrelide__HA1E__trt_cp | anagrelide__HA1E__trt_cp | -2.888882 |\n",
"| tributyltin__HA1E__trt_cp | tributyltin__HA1E__trt_cp | -3.094550 |\n",
"\n"
],
"text/plain": [
" Drug \n",
"triphenyl-tin__HA1E__trt_cp triphenyl-tin__HA1E__trt_cp \n",
"AVA__HA1E__trt_cp AVA__HA1E__trt_cp \n",
"ST-638__HA1E__trt_cp ST-638__HA1E__trt_cp \n",
"BRD-A51929314__HA1E__trt_cp BRD-A51929314__HA1E__trt_cp \n",
"BRD-K05402890__HA1E__trt_cp BRD-K05402890__HA1E__trt_cp \n",
"aminomethyltransferase__HA1E__trt_cp aminomethyltransferase__HA1E__trt_cp\n",
"ARP-101__HA1E__trt_cp ARP-101__HA1E__trt_cp \n",
"R-59022__HA1E__trt_cp R-59022__HA1E__trt_cp \n",
"homoharringtonine__HA1E__trt_cp homoharringtonine__HA1E__trt_cp \n",
"anagrelide__HA1E__trt_cp anagrelide__HA1E__trt_cp \n",
"tributyltin__HA1E__trt_cp tributyltin__HA1E__trt_cp \n",
" mean.Zscore\n",
"triphenyl-tin__HA1E__trt_cp -2.005953 \n",
"AVA__HA1E__trt_cp -2.028199 \n",
"ST-638__HA1E__trt_cp -2.139165 \n",
"BRD-A51929314__HA1E__trt_cp -2.227154 \n",
"BRD-K05402890__HA1E__trt_cp -2.309873 \n",
"aminomethyltransferase__HA1E__trt_cp -2.349426 \n",
"ARP-101__HA1E__trt_cp -2.420850 \n",
"R-59022__HA1E__trt_cp -2.440392 \n",
"homoharringtonine__HA1E__trt_cp -2.545411 \n",
"anagrelide__HA1E__trt_cp -2.888882 \n",
"tributyltin__HA1E__trt_cp -3.094550 "
]
},
"metadata": {},
"output_type": "display_data"
}
],
"source": [
"####identify the candidate drugs with Z-score\n",
"mean.drug <- tapply(RCC.drug.result$ZSCORE, as.character(RCC.drug.result$Drug), mean)\n",
"mean.drug <- data.frame(Drug = names(mean.drug), mean.Zscore = mean.drug)\n",
"mean.drug <- mean.drug[order(mean.drug$mean.Zscore, decreasing = T),]\n",
"mean.drug\n",
"\n",
"rankMean <- RCC.drug.result\n",
"rankMean$Drug <- factor(rankMean $Drug, levels = mean.drug$Drug)\n",
"rankMean <- arrange(rankMean, Drug)\n",
"write_xlsx(rankMean, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.drug.meanRank.xlsx\")"
]
},
{
"cell_type": "code",
"execution_count": 42,
"id": "f972ca60-a183-4218-af20-0ce0be77891c",
"metadata": {
"execution": {
"iopub.execute_input": "2021-09-23T06:23:30.857272Z",
"iopub.status.busy": "2021-09-23T06:23:30.822297Z",
"iopub.status.idle": "2021-09-23T06:23:30.904004Z",
"shell.execute_reply": "2021-09-23T06:23:30.902795Z"
},
"tags": [],
"vscode": {
"languageId": "r"
}
},
"outputs": [
{
"data": {
"text/html": [
"<table class=\"dataframe\">\n",
"<caption>A data.frame: 11 × 5</caption>\n",
"<thead>\n",
"\t<tr><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
"\t<tr><th scope=col><fct></th><th scope=col><chr></th><th scope=col><dbl></th><th scope=col><fct></th><th scope=col><chr></th></tr>\n",
"</thead>\n",
"<tbody>\n",
"\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>HOXC5</td><td>-2.349426</td><td>aminomethyltransferase</td><td>HA1E</td></tr>\n",
"\t<tr><td>anagrelide__HA1E__trt_cp </td><td>ISL1 </td><td>-2.888882</td><td>anagrelide </td><td>HA1E</td></tr>\n",
"\t<tr><td>ARP-101__HA1E__trt_cp </td><td>HOXC5</td><td>-2.420850</td><td>ARP-101 </td><td>HA1E</td></tr>\n",
"\t<tr><td>AVA__HA1E__trt_cp </td><td>VENTX</td><td>-2.028199</td><td>AVA </td><td>HA1E</td></tr>\n",
"\t<tr><td>BRD-A51929314__HA1E__trt_cp </td><td>ISL1 </td><td>-2.227154</td><td>BRD-A51929314 </td><td>HA1E</td></tr>\n",
"\t<tr><td>BRD-K05402890__HA1E__trt_cp </td><td>ISL1 </td><td>-2.309873</td><td>BRD-K05402890 </td><td>HA1E</td></tr>\n",
"\t<tr><td>homoharringtonine__HA1E__trt_cp </td><td>HOXC5</td><td>-2.545411</td><td>homoharringtonine </td><td>HA1E</td></tr>\n",
"\t<tr><td>R-59022__HA1E__trt_cp </td><td>HOXC5</td><td>-2.440392</td><td>R-59022 </td><td>HA1E</td></tr>\n",
"\t<tr><td>ST-638__HA1E__trt_cp </td><td>ISL1 </td><td>-2.139165</td><td>ST-638 </td><td>HA1E</td></tr>\n",
"\t<tr><td>tributyltin__HA1E__trt_cp </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin </td><td>HA1E</td></tr>\n",
"\t<tr><td>triphenyl-tin__HA1E__trt_cp </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin </td><td>HA1E</td></tr>\n",
"</tbody>\n",
"</table>\n"
],
"text/latex": [
"A data.frame: 11 × 5\n",
"\\begin{tabular}{lllll}\n",
" Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
" <fct> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
"\\hline\n",
"\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.349426 & aminomethyltransferase & HA1E\\\\\n",
"\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.888882 & anagrelide & HA1E\\\\\n",
"\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.420850 & ARP-101 & HA1E\\\\\n",
"\t AVA\\_\\_HA1E\\_\\_trt\\_cp & VENTX & -2.028199 & AVA & HA1E\\\\\n",
"\t BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.227154 & BRD-A51929314 & HA1E\\\\\n",
"\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.309873 & BRD-K05402890 & HA1E\\\\\n",
"\t homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.545411 & homoharringtonine & HA1E\\\\\n",
"\t R-59022\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.440392 & R-59022 & HA1E\\\\\n",
"\t ST-638\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.139165 & ST-638 & HA1E\\\\\n",
"\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -3.094550 & tributyltin & HA1E\\\\\n",
"\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & ISL1 & -2.005953 & triphenyl-tin & HA1E\\\\\n",
"\\end{tabular}\n"
],
"text/markdown": [
"\n",
"A data.frame: 11 × 5\n",
"\n",
"| Drug <fct> | TF <chr> | ZSCORE <dbl> | Drug.name <fct> | cellLine <chr> |\n",
"|---|---|---|---|---|\n",
"| aminomethyltransferase__HA1E__trt_cp | HOXC5 | -2.349426 | aminomethyltransferase | HA1E |\n",
"| anagrelide__HA1E__trt_cp | ISL1 | -2.888882 | anagrelide | HA1E |\n",
"| ARP-101__HA1E__trt_cp | HOXC5 | -2.420850 | ARP-101 | HA1E |\n",
"| AVA__HA1E__trt_cp | VENTX | -2.028199 | AVA | HA1E |\n",
"| BRD-A51929314__HA1E__trt_cp | ISL1 | -2.227154 | BRD-A51929314 | HA1E |\n",
"| BRD-K05402890__HA1E__trt_cp | ISL1 | -2.309873 | BRD-K05402890 | HA1E |\n",
"| homoharringtonine__HA1E__trt_cp | HOXC5 | -2.545411 | homoharringtonine | HA1E |\n",
"| R-59022__HA1E__trt_cp | HOXC5 | -2.440392 | R-59022 | HA1E |\n",
"| ST-638__HA1E__trt_cp | ISL1 | -2.139165 | ST-638 | HA1E |\n",
"| tributyltin__HA1E__trt_cp | ISL1 | -3.094550 | tributyltin | HA1E |\n",
"| triphenyl-tin__HA1E__trt_cp | ISL1 | -2.005953 | triphenyl-tin | HA1E |\n",
"\n"
],
"text/plain": [
" Drug TF ZSCORE Drug.name \n",
"1 aminomethyltransferase__HA1E__trt_cp HOXC5 -2.349426 aminomethyltransferase\n",
"2 anagrelide__HA1E__trt_cp ISL1 -2.888882 anagrelide \n",
"3 ARP-101__HA1E__trt_cp HOXC5 -2.420850 ARP-101 \n",
"4 AVA__HA1E__trt_cp VENTX -2.028199 AVA \n",
"5 BRD-A51929314__HA1E__trt_cp ISL1 -2.227154 BRD-A51929314 \n",
"6 BRD-K05402890__HA1E__trt_cp ISL1 -2.309873 BRD-K05402890 \n",
"7 homoharringtonine__HA1E__trt_cp HOXC5 -2.545411 homoharringtonine \n",
"8 R-59022__HA1E__trt_cp HOXC5 -2.440392 R-59022 \n",
"9 ST-638__HA1E__trt_cp ISL1 -2.139165 ST-638 \n",
"10 tributyltin__HA1E__trt_cp ISL1 -3.094550 tributyltin \n",
"11 triphenyl-tin__HA1E__trt_cp ISL1 -2.005953 triphenyl-tin \n",
" cellLine\n",
"1 HA1E \n",
"2 HA1E \n",
"3 HA1E \n",
"4 HA1E \n",
"5 HA1E \n",
"6 HA1E \n",
"7 HA1E \n",
"8 HA1E \n",
"9 HA1E \n",
"10 HA1E \n",
"11 HA1E "
]
},
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"output_type": "display_data"
}
],
"source": [
"#### drug down-regulated the gene expression\n",
"negative.zscore <- RCC.drug.result[which(RCC.drug.result$ZSCORE<0),]\n",
"negative.zscore.mean <- tapply(negative.zscore$ZSCORE, as.character(negative.zscore$Drug), mean)\n",
"negative.zscore.mean <- data.frame(Drug = names(negative.zscore.mean), mean.Zscore = negative.zscore.mean)\n",
"negative.zscore.mean <- negative.zscore.mean[order(negative.zscore.mean$mean.Zscore),]\n",
"#negative.zscore.mean\n",
"\n",
"negative.rankMean <- negative.zscore\n",
"negative.rankMean$Drug.name <- gsub(\"__.*\", \"\", negative.rankMean$Drug)\n",
"idx <- names(sort(table(negative.rankMean$Drug.name), decreasing = T))\n",
"negative.rankMean$Drug.name <- factor(negative.rankMean$Drug.name, levels = idx)\n",
"negative.rankMean <- arrange(negative.rankMean, Drug.name)\n",
"write_xlsx(negative.rankMean, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.drug.negative.rankMean.xlsx\")\n",
"negative.rankMean"
]
}
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