{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 17,
   "id": "f51e6ed2-079a-4a9c-a41d-02a11c95954c",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:08:54.360100Z",
     "iopub.status.busy": "2021-09-23T06:08:54.356702Z",
     "iopub.status.idle": "2021-09-23T06:08:59.232023Z",
     "shell.execute_reply": "2021-09-23T06:08:59.230494Z"
    },
    "scrolled": true,
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "snapshotDate(): 2020-10-27\n",
      "\n"
     ]
    }
   ],
   "source": [
    "library(ExperimentHub)\n",
    "library(HDF5Array)\n",
    "library(SummarizedExperiment)\n",
    "eh <- ExperimentHub() \n",
    "setwd(\"/data/ExtraDisk/sdd/longzhilin/Data/drugData/CMAP_LINCS_2020\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "id": "997d397b-78a1-4caa-9f02-57c6a7d7bfe0",
   "metadata": {
    "collapsed": true,
    "execution": {
     "iopub.execute_input": "2021-09-23T06:10:39.616836Z",
     "iopub.status.busy": "2021-09-23T06:10:39.613417Z",
     "iopub.status.idle": "2021-09-23T06:11:13.488294Z",
     "shell.execute_reply": "2021-09-23T06:11:13.487016Z"
    },
    "jupyter": {
     "outputs_hidden": true
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "ExperimentHub with 4 records\n",
       "# snapshotDate(): 2020-10-27\n",
       "# $dataprovider: Broad Institute, DrugBank, Broad Institute, STITCH\n",
       "# $species: Homo sapiens\n",
       "# $rdataclass: character, list\n",
       "# additional mcols(): taxonomyid, genome, description,\n",
       "#   coordinate_1_based, maintainer, rdatadateadded, preparerclass, tags,\n",
       "#   rdatapath, sourceurl, sourcetype \n",
       "# retrieve records with, e.g., 'object[[\"EH3226\"]]' \n",
       "\n",
       "           title             \n",
       "  EH3226 | lincs             \n",
       "  EH3227 | lincs_expr        \n",
       "  EH3228 | dtlink_db_clue_sti\n",
       "  EH3233 | taurefList        "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "see ?signatureSearchData and browseVignettes('signatureSearchData') for documentation\n",
      "\n",
      "loading from cache\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 3 × 5</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>group</th><th scope=col>name</th><th scope=col>otype</th><th scope=col>dclass</th><th scope=col>dim</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>0</th><td>/</td><td>assay   </td><td>H5I_DATASET</td><td>FLOAT </td><td>12328 x 45956</td></tr>\n",
       "\t<tr><th scope=row>1</th><td>/</td><td>colnames</td><td>H5I_DATASET</td><td>STRING</td><td>45956 x 1    </td></tr>\n",
       "\t<tr><th scope=row>2</th><td>/</td><td>rownames</td><td>H5I_DATASET</td><td>STRING</td><td>12328 x 1    </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 3 × 5\n",
       "\\begin{tabular}{r|lllll}\n",
       "  & group & name & otype & dclass & dim\\\\\n",
       "  & <chr> & <chr> & <chr> & <chr> & <chr>\\\\\n",
       "\\hline\n",
       "\t0 & / & assay    & H5I\\_DATASET & FLOAT  & 12328 x 45956\\\\\n",
       "\t1 & / & colnames & H5I\\_DATASET & STRING & 45956 x 1    \\\\\n",
       "\t2 & / & rownames & H5I\\_DATASET & STRING & 12328 x 1    \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 3 × 5\n",
       "\n",
       "| <!--/--> | group &lt;chr&gt; | name &lt;chr&gt; | otype &lt;chr&gt; | dclass &lt;chr&gt; | dim &lt;chr&gt; |\n",
       "|---|---|---|---|---|---|\n",
       "| 0 | / | assay    | H5I_DATASET | FLOAT  | 12328 x 45956 |\n",
       "| 1 | / | colnames | H5I_DATASET | STRING | 45956 x 1     |\n",
       "| 2 | / | rownames | H5I_DATASET | STRING | 12328 x 1     |\n",
       "\n"
      ],
      "text/plain": [
       "  group name     otype       dclass dim          \n",
       "0 /     assay    H5I_DATASET FLOAT  12328 x 45956\n",
       "1 /     colnames H5I_DATASET STRING 45956 x 1    \n",
       "2 /     rownames H5I_DATASET STRING 12328 x 1    "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
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       "\t<tr><th scope=row>2185</th><td>-0.59829998</td><td>-2.5377</td><td> 4.76999998</td><td>-0.27070001</td><td>-2.783349991</td><td> 1.25042439</td><td>-0.24249998</td><td>-3.3810499</td><td>-0.36440000</td><td> 0.63944995</td><td>⋯</td><td> 2.5788</td><td> 1.2502</td><td> 1.2122</td><td> 0.2189</td><td>-0.3260</td><td>-0.4259</td><td>-0.4624</td><td> 1.4268</td><td>-1.4473</td><td> 2.8440</td></tr>\n",
       "\t<tr><th scope=row>3315</th><td>-0.22889999</td><td>-1.1686</td><td> 1.73409986</td><td> 0.21175002</td><td>-3.493849993</td><td> 0.21799627</td><td>-0.32495001</td><td>-2.3188000</td><td>-0.12619999</td><td>-0.08780000</td><td>⋯</td><td> 0.0000</td><td>-0.5599</td><td>-0.7747</td><td> 0.9959</td><td>-0.9554</td><td>-0.6129</td><td> 2.3237</td><td>-0.7365</td><td>-0.4083</td><td>-3.0874</td></tr>\n",
       "\t<tr><th scope=row>5289</th><td> 0.04359999</td><td> 3.6465</td><td> 3.03125000</td><td> 0.90630001</td><td> 0.187049985</td><td> 3.19396544</td><td>-0.23465000</td><td> 1.0276000</td><td>-0.56045002</td><td>-0.05330001</td><td>⋯</td><td> 0.8281</td><td>-0.9206</td><td> 0.6822</td><td>-0.9480</td><td>-0.2322</td><td>-1.1048</td><td> 0.8300</td><td> 0.4654</td><td>-0.5206</td><td> 0.6745</td></tr>\n",
       "\t<tr><th scope=row>868</th><td> 0.10220000</td><td> 0.8592</td><td> 1.81244993</td><td>-0.25509998</td><td> 0.549250007</td><td>-0.19470868</td><td>-0.59965003</td><td> 0.4235500</td><td>-0.48370001</td><td>-1.28314996</td><td>⋯</td><td> 0.1421</td><td> 0.7650</td><td> 0.4446</td><td> 0.2584</td><td> 0.1067</td><td> 0.5922</td><td> 1.3067</td><td>-0.8527</td><td>-0.3135</td><td> 0.8328</td></tr>\n",
       "\t<tr><th scope=row>1677</th><td>-0.20805000</td><td> 0.7930</td><td> 1.97329998</td><td> 0.54895002</td><td>-0.111049995</td><td> 1.75220299</td><td>-0.52419996</td><td> 0.9599000</td><td>-0.76335001</td><td>-0.10170000</td><td>⋯</td><td> 0.3969</td><td> 0.9042</td><td> 0.0418</td><td> 0.4508</td><td> 0.3277</td><td> 4.0569</td><td>-3.5420</td><td>-0.8606</td><td>-0.0633</td><td> 2.4948</td></tr>\n",
       "\t<tr><th scope=row>7043</th><td>-0.27850002</td><td> 2.4205</td><td> 0.82440001</td><td>-0.50725001</td><td> 1.212399960</td><td>-0.33966029</td><td>-0.46219999</td><td> 0.2445500</td><td>-0.48930001</td><td> 0.63644999</td><td>⋯</td><td> 0.0147</td><td> 1.1314</td><td> 1.5184</td><td> 1.1396</td><td>-0.7535</td><td>-0.1550</td><td>-0.5552</td><td> 0.9483</td><td> 0.5121</td><td> 0.9929</td></tr>\n",
       "\t<tr><th scope=row>5613</th><td>-0.66865003</td><td> 0.5340</td><td> 3.83539987</td><td> 0.60944998</td><td>-1.195199966</td><td> 1.74077058</td><td>-0.14775001</td><td>-0.1435000</td><td> 0.24705002</td><td> 0.45889997</td><td>⋯</td><td> 0.0717</td><td> 0.5023</td><td> 0.3477</td><td>-2.3664</td><td>-0.3586</td><td>-0.3032</td><td>-0.4723</td><td>-0.3586</td><td>-0.7751</td><td> 1.1149</td></tr>\n",
       "\t<tr><th scope=row>⋮</th><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋱</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td></tr>\n",
       "\t<tr><th scope=row>54552</th><td>-0.547550023</td><td> 0.5666</td><td> 0.74390000</td><td>-0.32515001</td><td> 1.286950111</td><td> 0.6714719</td><td>-0.372799993</td><td> 1.4985501</td><td>-0.04715000</td><td>-0.15339999</td><td>⋯</td><td> 1.8504</td><td>-0.2516</td><td> 1.3114</td><td>-0.1993</td><td>-1.4090</td><td>-0.4407</td><td>-2.0924</td><td> 0.6877</td><td> 0.7649</td><td>-0.1186</td></tr>\n",
       "\t<tr><th scope=row>54920</th><td>-0.190850005</td><td> 2.6847</td><td> 0.61905003</td><td> 0.51645005</td><td>-0.408650011</td><td> 1.7125645</td><td>-0.076900005</td><td>-0.5360000</td><td>-1.17120004</td><td> 0.30594999</td><td>⋯</td><td> 0.4583</td><td> 0.8514</td><td> 0.3027</td><td> 1.4400</td><td>-1.0779</td><td>-0.6745</td><td> 0.0638</td><td> 0.4723</td><td> 0.0850</td><td> 0.7503</td></tr>\n",
       "\t<tr><th scope=row>11178</th><td>-0.007799983</td><td> 1.4589</td><td> 0.63424999</td><td>-0.62494999</td><td> 0.307300001</td><td>-0.3424515</td><td>-0.897199988</td><td> 0.0240500</td><td>-0.16354999</td><td> 0.00515002</td><td>⋯</td><td>-1.7519</td><td> 0.3908</td><td>-1.0155</td><td>-0.2487</td><td>-0.6887</td><td>-0.6171</td><td>-0.5462</td><td>-0.1172</td><td>-1.4105</td><td> 0.1631</td></tr>\n",
       "\t<tr><th scope=row>93643</th><td>-0.781599998</td><td> 0.9777</td><td> 2.61190009</td><td> 0.64004999</td><td> 0.713050008</td><td> 0.9237132</td><td> 0.206200004</td><td> 0.4028500</td><td> 0.18150002</td><td>-1.33759999</td><td>⋯</td><td> 2.1395</td><td>-0.4617</td><td> 1.2257</td><td> 0.0263</td><td>-1.3893</td><td>-1.9883</td><td> 0.7824</td><td> 0.2161</td><td>-0.5916</td><td> 2.0450</td></tr>\n",
       "\t<tr><th scope=row>112869</th><td>-0.174050003</td><td> 0.1336</td><td>-0.16070001</td><td> 0.83440006</td><td> 0.434750021</td><td> 0.5052795</td><td> 0.133000001</td><td>-0.2637000</td><td>-0.80325001</td><td>-0.37760001</td><td>⋯</td><td> 2.3786</td><td> 1.1703</td><td> 1.1386</td><td> 0.7210</td><td>-0.1182</td><td>-0.0510</td><td>-1.0956</td><td> 0.8456</td><td>-0.5989</td><td> 1.1402</td></tr>\n",
       "\t<tr><th scope=row>51147</th><td>-0.131500006</td><td> 2.5702</td><td> 2.79585004</td><td> 0.60960001</td><td> 1.184949994</td><td> 0.1883786</td><td>-0.194200009</td><td> 0.8002999</td><td>-0.16949999</td><td> 0.07554999</td><td>⋯</td><td> 1.9107</td><td> 1.5612</td><td> 0.3518</td><td> 1.2840</td><td>-1.4728</td><td>-0.3504</td><td> 0.0130</td><td> 0.4459</td><td>-0.4840</td><td> 0.9162</td></tr>\n",
       "\t<tr><th scope=row>196403</th><td>-0.179949999</td><td> 3.3629</td><td> 2.99699998</td><td> 1.06465006</td><td> 0.325349987</td><td> 1.2875153</td><td>-0.328400016</td><td> 1.8518502</td><td>-0.13325000</td><td>-1.07975006</td><td>⋯</td><td> 1.4798</td><td> 0.1850</td><td> 1.3844</td><td> 0.3240</td><td>-0.4564</td><td> 0.3414</td><td> 0.1307</td><td> 0.2026</td><td>-1.4586</td><td> 1.7090</td></tr>\n",
       "\t<tr><th scope=row>389677</th><td>-0.299800009</td><td>-1.7546</td><td> 1.62085009</td><td> 0.17885001</td><td> 0.346049994</td><td> 2.1395676</td><td> 0.425999999</td><td> 0.2757500</td><td>-0.60355002</td><td>-0.66229999</td><td>⋯</td><td> 0.6175</td><td>-0.6872</td><td> 1.1080</td><td>-0.3949</td><td>-0.7650</td><td> 0.6032</td><td>-0.5789</td><td> 0.8575</td><td> 1.2912</td><td>-0.5854</td></tr>\n",
       "\t<tr><th scope=row>1296</th><td>-0.568499982</td><td> 4.0283</td><td> 1.80404997</td><td> 0.68540001</td><td> 1.193750024</td><td>-0.3998278</td><td>-0.204600006</td><td> 2.2550499</td><td> 0.10470000</td><td> 0.11945000</td><td>⋯</td><td> 0.9755</td><td> 0.6923</td><td>-0.1845</td><td> 0.1797</td><td>-0.0929</td><td> 0.0885</td><td> 0.6156</td><td> 0.2872</td><td>-0.6606</td><td> 0.7912</td></tr>\n",
       "\t<tr><th scope=row>85352</th><td>-0.582249999</td><td> 2.8892</td><td> 2.65304995</td><td> 0.62145001</td><td> 0.426599979</td><td> 1.1645755</td><td> 0.086000010</td><td> 1.2165500</td><td> 0.69494998</td><td>-0.19315001</td><td>⋯</td><td>-0.0009</td><td> 3.7638</td><td> 1.6589</td><td> 0.1591</td><td>-0.6720</td><td>-1.0518</td><td>-1.5408</td><td>-0.1605</td><td> 0.1139</td><td> 2.4243</td></tr>\n",
       "\t<tr><th scope=row>57610</th><td> 0.498400003</td><td> 5.1220</td><td> 2.16345000</td><td> 0.01574999</td><td> 0.200550005</td><td> 0.1731201</td><td>-0.926600039</td><td> 0.0807500</td><td>-0.57225001</td><td> 0.07119998</td><td>⋯</td><td> 1.5447</td><td>-0.0599</td><td> 1.6722</td><td> 0.2858</td><td> 1.6272</td><td>-0.8244</td><td> 0.9907</td><td> 0.4710</td><td> 0.1368</td><td> 1.4276</td></tr>\n",
       "\t<tr><th scope=row>27147</th><td>-0.202250004</td><td> 2.5838</td><td> 1.67175007</td><td>-0.22469999</td><td> 1.058600068</td><td> 0.6260329</td><td>-0.410300016</td><td> 0.1346500</td><td>-0.54540002</td><td>-0.01105000</td><td>⋯</td><td> 1.3721</td><td>-0.4534</td><td>-0.3415</td><td> 0.3251</td><td>-1.3887</td><td> 0.4315</td><td> 0.1750</td><td>-0.6396</td><td>-1.0847</td><td> 1.3937</td></tr>\n",
       "\t<tr><th scope=row>79591</th><td> 1.026950002</td><td> 2.7480</td><td>-0.06799999</td><td> 0.64854997</td><td> 1.501299977</td><td> 1.2647009</td><td> 0.523100019</td><td>-0.0559500</td><td> 0.24710000</td><td> 0.37870002</td><td>⋯</td><td> 2.1479</td><td> 1.1361</td><td>-0.7604</td><td> 1.6378</td><td>-0.0226</td><td> 0.0510</td><td>-0.0003</td><td>-0.4592</td><td> 0.8158</td><td> 1.6554</td></tr>\n",
       "\t<tr><th scope=row>92595</th><td> 0.652800024</td><td>-0.7214</td><td> 0.21370000</td><td> 0.66485000</td><td> 1.284350038</td><td> 0.5647974</td><td> 0.559400022</td><td> 1.5563999</td><td> 0.02030000</td><td>-0.36090001</td><td>⋯</td><td> 0.3339</td><td> 1.3473</td><td> 0.0010</td><td> 0.0615</td><td>-0.2524</td><td> 0.0479</td><td>-0.3532</td><td>-0.2950</td><td> 0.0858</td><td> 0.1184</td></tr>\n",
       "\t<tr><th scope=row>51063</th><td> 0.343500018</td><td>-0.8015</td><td> 0.33515000</td><td> 1.91869998</td><td> 0.368699998</td><td> 0.5586674</td><td>-0.298150003</td><td> 0.2594000</td><td> 0.28309998</td><td> 0.09540004</td><td>⋯</td><td> 0.9597</td><td> 1.8933</td><td> 1.1444</td><td> 0.9759</td><td>-0.1300</td><td>-0.5763</td><td>-0.3481</td><td>-1.0736</td><td>-0.0896</td><td> 1.2923</td></tr>\n",
       "\t<tr><th scope=row>55223</th><td>-0.215350002</td><td> 4.3713</td><td> 1.97140002</td><td> 0.29425001</td><td> 1.258400083</td><td> 0.8483824</td><td> 0.505299985</td><td> 0.4320000</td><td>-0.73879999</td><td>-1.00734997</td><td>⋯</td><td>-0.7425</td><td> 1.5926</td><td> 0.3204</td><td> 0.3486</td><td>-1.2565</td><td>-0.0055</td><td>-0.3076</td><td>-0.5895</td><td>-0.6759</td><td> 1.1372</td></tr>\n",
       "\t<tr><th scope=row>80022</th><td>-0.499350011</td><td> 3.3540</td><td> 2.46420002</td><td> 0.21785000</td><td>-0.007000007</td><td> 1.1016043</td><td> 0.208849996</td><td>-0.3577000</td><td>-0.80614996</td><td> 0.93999994</td><td>⋯</td><td> 1.0909</td><td> 0.1379</td><td> 0.6538</td><td> 0.9385</td><td>-0.8598</td><td>-0.1190</td><td>-1.1109</td><td> 0.0832</td><td>-0.2971</td><td> 0.8936</td></tr>\n",
       "\t<tr><th scope=row>55589</th><td> 0.989849985</td><td>-1.7614</td><td>-0.52405000</td><td>-0.53944999</td><td> 2.766950130</td><td>-1.4092908</td><td> 0.037900001</td><td> 0.5296500</td><td> 0.20385003</td><td>-0.57599998</td><td>⋯</td><td>-1.7398</td><td> 1.1566</td><td>-0.5645</td><td> 1.4264</td><td> 1.8400</td><td>-0.1273</td><td> 1.2060</td><td> 0.2184</td><td> 1.3779</td><td>-0.5626</td></tr>\n",
       "\t<tr><th scope=row>376267</th><td>-0.697149992</td><td> 1.8690</td><td> 0.45809996</td><td>-0.03180003</td><td> 1.338700056</td><td>-0.2823215</td><td>-0.157900006</td><td> 1.0916001</td><td>-0.20415001</td><td>-0.42180002</td><td>⋯</td><td> 0.1199</td><td> 1.2685</td><td> 0.9052</td><td> 0.0267</td><td> 0.0809</td><td>-1.1636</td><td> 0.2976</td><td> 1.9446</td><td>-0.9014</td><td> 1.8036</td></tr>\n",
       "\t<tr><th scope=row>84820</th><td>-0.152749985</td><td> 1.8001</td><td> 1.37894988</td><td> 0.01440001</td><td> 1.192999959</td><td> 1.6359860</td><td>-0.251900017</td><td> 1.5041499</td><td>-0.12639999</td><td>-0.49724999</td><td>⋯</td><td> 1.1424</td><td>-0.0597</td><td> 0.7671</td><td> 0.5935</td><td>-0.5742</td><td>-1.0844</td><td>-0.5707</td><td> 2.0601</td><td>-0.2694</td><td> 1.1255</td></tr>\n",
       "\t<tr><th scope=row>2931</th><td>-0.489800006</td><td> 4.3996</td><td> 2.27640009</td><td> 0.27145001</td><td>-0.035150021</td><td> 0.5720488</td><td>-0.576700032</td><td> 0.1173000</td><td>-0.68005002</td><td> 0.33640003</td><td>⋯</td><td> 0.2727</td><td> 0.5013</td><td> 0.8471</td><td> 0.2688</td><td> 0.7681</td><td>-0.5762</td><td>-0.8154</td><td>-0.0992</td><td>-0.7370</td><td> 1.7226</td></tr>\n",
       "\t<tr><th scope=row>63876</th><td>-0.252000004</td><td> 2.4605</td><td> 1.21990001</td><td>-0.08165000</td><td> 1.008049965</td><td> 0.7371939</td><td>-0.005400002</td><td> 0.2307501</td><td>-0.44770002</td><td>-0.46705002</td><td>⋯</td><td>-0.7579</td><td>-0.6265</td><td> 0.8404</td><td>-0.2692</td><td> 0.8911</td><td>-0.2046</td><td>-0.8071</td><td>-0.1506</td><td>-1.6715</td><td> 0.9172</td></tr>\n",
       "\t<tr><th scope=row>51275</th><td>-0.829549968</td><td> 2.4557</td><td> 2.40814996</td><td> 0.42320001</td><td>-0.335050017</td><td>-0.9146695</td><td> 0.963299990</td><td> 1.4400499</td><td> 0.39770001</td><td> 0.27579999</td><td>⋯</td><td> 0.3883</td><td> 0.6793</td><td> 0.3237</td><td>-0.4276</td><td> 0.7665</td><td> 0.5685</td><td>-1.0498</td><td> 1.5715</td><td>-1.7042</td><td>-0.0870</td></tr>\n",
       "\t<tr><th scope=row>158747</th><td>-0.933599949</td><td> 2.2661</td><td> 2.48624992</td><td> 1.50850010</td><td>-1.788749933</td><td>-0.1306736</td><td>-0.646350026</td><td>-1.1307499</td><td> 0.18900004</td><td> 1.36570001</td><td>⋯</td><td> 2.4502</td><td> 1.9125</td><td> 0.2526</td><td> 0.5455</td><td> 0.1402</td><td>-0.9180</td><td>-1.9362</td><td> 1.3076</td><td>-0.5795</td><td> 0.3890</td></tr>\n",
       "\t<tr><th scope=row>283232</th><td>-0.549999952</td><td> 1.0838</td><td> 0.41525000</td><td>-0.09474999</td><td> 1.855700016</td><td>-0.2727659</td><td>-0.094699994</td><td> 1.7906501</td><td>-0.75310004</td><td> 0.58985001</td><td>⋯</td><td> 0.3257</td><td> 1.1194</td><td> 0.5754</td><td>-0.4345</td><td>-3.3375</td><td> 0.5196</td><td>-1.5637</td><td> 1.1416</td><td> 0.2517</td><td>-0.1119</td></tr>\n",
       "\t<tr><th scope=row>25960</th><td> 0.060000002</td><td> 1.8776</td><td> 0.34240001</td><td>-0.22815000</td><td> 1.623250008</td><td>-0.5708635</td><td> 0.072649986</td><td> 0.1602500</td><td> 0.26474997</td><td> 0.05900000</td><td>⋯</td><td> 0.8320</td><td>-0.3680</td><td> 0.6608</td><td>-0.2463</td><td>-2.4105</td><td> 0.1107</td><td>-0.2676</td><td> 0.6119</td><td> 1.1775</td><td> 0.9155</td></tr>\n",
       "\t<tr><th scope=row>6376</th><td>-0.391449988</td><td> 2.0942</td><td> 1.54129994</td><td> 0.29714999</td><td>-0.322299987</td><td> 0.6695740</td><td> 0.684000015</td><td>-0.2364000</td><td>-0.22969997</td><td>-1.19679999</td><td>⋯</td><td> 1.1901</td><td>-0.0144</td><td> 1.5630</td><td> 0.3335</td><td> 1.0411</td><td>-1.1291</td><td> 0.6466</td><td> 1.4029</td><td>-1.0273</td><td> 0.0192</td></tr>\n",
       "\t<tr><th scope=row>11033</th><td>-0.816999972</td><td> 0.0360</td><td> 1.86659992</td><td> 1.18130004</td><td>-1.078150034</td><td> 2.5671935</td><td>-0.160849988</td><td> 0.1246000</td><td> 1.15509999</td><td> 0.12650001</td><td>⋯</td><td> 1.2484</td><td>-0.1491</td><td> 0.0777</td><td> 0.3478</td><td>-0.7770</td><td>-0.2837</td><td>-0.0944</td><td> 0.7815</td><td>-0.3094</td><td> 2.2588</td></tr>\n",
       "\t<tr><th scope=row>54869</th><td>-0.491949975</td><td> 3.9373</td><td> 2.89374995</td><td> 0.08510001</td><td>-1.110100031</td><td> 1.1950539</td><td>-0.178350002</td><td> 1.4240000</td><td>-0.01594999</td><td> 1.36944997</td><td>⋯</td><td>-0.1743</td><td> 1.0657</td><td> 0.7791</td><td> 1.0932</td><td>-0.5247</td><td>-0.5104</td><td>-0.2863</td><td>-0.5035</td><td> 1.2087</td><td> 2.5072</td></tr>\n",
       "\t<tr><th scope=row>60</th><td>-0.487500012</td><td>-0.0225</td><td>-0.53219998</td><td>-0.72780001</td><td>-0.636449993</td><td>-0.1309013</td><td>-0.509249985</td><td>-0.4348000</td><td> 0.53165001</td><td> 0.25479999</td><td>⋯</td><td>-1.4556</td><td>-0.2475</td><td>-0.6307</td><td>-0.2042</td><td> 0.7773</td><td> 0.3077</td><td> 1.8114</td><td>-1.0285</td><td> 0.0535</td><td>-1.3198</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A matrix: 12328 × 45956 of type dbl\n",
       "\\begin{tabular}{r|lllllllllllllllllllll}\n",
       "  & BRD-A03772856\\_\\_CD34\\_\\_trt\\_cp & trichostatin-a\\_\\_CD34\\_\\_trt\\_cp & geldanamycin\\_\\_CD34\\_\\_trt\\_cp & KUC107191N\\_\\_CD34\\_\\_trt\\_cp & BRD-A35207501\\_\\_CD34\\_\\_trt\\_cp & iloprost\\_\\_CD34\\_\\_trt\\_cp & BRD-A72498772\\_\\_CD34\\_\\_trt\\_cp & BRD-A72796238\\_\\_CD34\\_\\_trt\\_cp & BRD-A73513677\\_\\_CD34\\_\\_trt\\_cp & BRD-A73558769\\_\\_CD34\\_\\_trt\\_cp & ⋯ & MW-MITF24\\_\\_MCF7\\_\\_trt\\_cp & l-buthionine-sulfoximine\\_\\_PC3\\_\\_trt\\_cp & alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & cisplatin\\_\\_PC3\\_\\_trt\\_cp & iniparib\\_\\_PC3\\_\\_trt\\_cp & JMW-MITF1\\_\\_PC3\\_\\_trt\\_cp & bortezomib\\_\\_PC3\\_\\_trt\\_cp & selumetinib\\_\\_PC3\\_\\_trt\\_cp & glutamine\\_\\_PC3\\_\\_trt\\_cp & MW-MITF24\\_\\_PC3\\_\\_trt\\_cp\\\\\n",
       "\\hline\n",
       "\t5720 &  0.36540002 & -1.9333 & -1.78014994 & -0.61925000 & -0.729250073 & -2.01719809 &  0.18455000 & -1.1793000 &  0.34680000 &  0.10225001 & ⋯ & -2.1606 & -0.2913 & -1.2731 & -0.5659 &  0.4571 &  0.0308 & -0.2913 & -0.9489 & -1.0550 & -1.9929\\\\\n",
       "\t466 &  0.69385004 & -4.0653 & -2.45910001 &  0.05739999 &  1.069949985 & -1.52120280 & -0.19575000 &  1.3569000 &  0.32670000 &  0.36719999 & ⋯ & -1.9576 & -0.6859 &  0.5907 & -0.2468 &  0.7582 &  0.4957 & -1.0830 &  0.3153 &  1.3292 & -0.5015\\\\\n",
       "\t6009 &  0.55435002 &  0.1850 &  0.22250000 &  0.05124998 &  0.336199999 & -1.32433784 &  0.78560001 & -0.2471000 &  1.50240004 & -0.47415000 & ⋯ & -1.9373 & -0.7577 & -1.8149 &  0.0000 &  0.3941 & -1.6190 &  0.1462 & -2.1747 & -0.2952 & -2.1053\\\\\n",
       "\t2309 & -0.31579998 &  2.2660 &  0.67035002 & -0.39039999 &  1.141200066 &  0.91430640 &  0.45165002 &  0.1099000 & -0.58609998 & -1.34329998 & ⋯ &  0.9808 & -0.0848 & -1.5376 &  0.6194 & -0.2978 &  0.5139 &  2.9324 & -0.9933 & -0.0140 & -1.1789\\\\\n",
       "\t387 &  0.37180001 & -0.2558 & -2.59875011 & -2.12490010 &  1.495700002 & -3.34633827 & -0.03835000 & -0.9017001 &  1.18655002 &  0.68274999 & ⋯ & -1.5168 &  0.0997 & -0.3862 &  0.1973 & -0.4246 & -0.5682 &  0.6157 & -0.3696 &  0.3436 & -3.2787\\\\\n",
       "\t3553 &  0.70824999 & -0.5149 & -0.73619998 & -0.41515002 &  1.960999966 &  0.22129090 & -0.20070001 &  0.8321000 &  2.93820000 & -0.08945002 & ⋯ &  3.2767 &  0.0000 & -0.1367 & -0.6745 & -1.0342 & -1.3800 & -0.9713 &  1.2338 & -1.3174 & -0.6564\\\\\n",
       "\t427 &  0.18295000 & -1.6045 &  0.42860001 &  0.30954999 &  1.228850007 &  0.06338993 &  0.44700000 &  0.3969500 &  0.57410002 & -0.11010003 & ⋯ &  0.5427 & -0.5669 & -0.7753 & -0.8029 &  1.6375 &  1.7251 &  1.2290 &  0.0243 & -0.7690 & -0.6058\\\\\n",
       "\t5898 & -0.40434998 &  3.5042 &  2.97979999 & -0.84810001 &  1.905500054 &  0.31654096 & -0.01730000 & -0.1905500 & -0.82900000 & -0.52789998 & ⋯ & -0.3057 &  0.1609 &  0.2776 &  0.0750 & -2.8649 &  0.5809 &  1.7948 & -0.0093 &  1.2902 &  0.2903\\\\\n",
       "\t23365 &  0.49500000 &  0.4630 &  0.48894998 & -0.25070000 &  0.521200001 & -0.62915254 & -0.67110002 & -0.7869500 &  0.49564999 &  1.38380003 & ⋯ & -0.7719 & -0.3665 &  0.7769 &  0.3405 & -0.6687 &  0.4276 & -2.5250 &  0.0963 &  0.0482 &  0.0963\\\\\n",
       "\t6657 & -0.58120000 &  2.3181 &  1.18390000 &  0.32394999 &  0.963199973 &  1.12940836 & -0.09670001 &  1.5269001 & -0.28994998 & -0.26674998 & ⋯ &  2.3400 &  0.8720 &  1.4368 &  0.5604 & -1.3073 & -0.8898 & -0.4415 &  0.7747 & -0.3321 &  2.5004\\\\\n",
       "\t5054 & -0.25055000 & -0.2075 & -0.43175000 &  0.16700003 &  1.369400024 &  1.35352969 & -0.11345001 &  0.5116500 & -0.07969996 & -0.21934998 & ⋯ &  0.6593 &  0.2299 &  0.5751 &  0.2370 &  0.4596 &  0.3050 & -1.6550 &  0.0137 &  0.4267 &  0.6745\\\\\n",
       "\t3108 & -0.06060000 & -1.8116 & -1.61284995 & -0.08275000 & -0.534399986 & -0.13355637 & -0.01085000 & -1.5620000 &  0.59775001 &  0.97039998 & ⋯ &  0.6745 &  0.3049 & -0.5842 & -0.3346 &  1.3939 & -0.4618 &  0.4915 &  0.0590 &  0.1180 &  1.7550\\\\\n",
       "\t1950 &  0.34324998 & -0.3875 &  1.33039999 &  0.69085002 & -1.051300049 &  3.66408134 &  0.38674998 &  2.6680501 & -0.73095000 & -0.51055002 & ⋯ &  0.8943 &  0.2505 &  1.1675 & -0.0811 & -0.4084 & -0.6610 & -0.0670 &  1.3110 & -1.1154 &  2.5754\\\\\n",
       "\t351 & -0.75015002 &  0.0000 &  1.67859995 &  0.01835000 &  0.958649993 &  0.42959470 &  0.31160000 &  0.9131501 &  0.33724999 & -0.51849997 & ⋯ &  1.2067 &  0.8746 & -1.4754 &  0.3245 &  1.2609 &  0.4734 &  1.3987 & -0.1130 & -0.8090 &  0.3988\\\\\n",
       "\t4846 &  0.44309998 &  2.6904 &  1.82799995 &  0.63379997 &  0.361950010 &  1.81054175 &  0.38900000 &  3.5537500 & -0.76929998 & -0.95864999 & ⋯ & -1.2723 &  1.0611 &  0.0000 &  0.8742 &  0.5819 &  0.4788 &  1.4877 & -0.3579 & -0.6335 & -0.7591\\\\\n",
       "\t1452 &  0.05585000 & -0.3123 &  0.57295001 & -0.44580001 &  0.636549950 & -0.72561306 & -3.03379989 & -0.7344500 &  0.70099998 &  0.10130000 & ⋯ & -1.9790 &  0.3489 & -0.7107 & -1.8170 &  0.3777 & -1.1747 &  1.5557 & -0.0845 & -1.1233 & -1.5332\\\\\n",
       "\t4776 & -0.92770004 &  0.6834 &  2.35645008 &  1.05629992 & -0.044949993 &  0.66652113 & -0.03335000 &  2.2428999 &  0.25165001 &  0.55704999 & ⋯ &  3.3373 &  0.5311 &  1.3320 &  0.3057 & -0.9554 & -0.9277 & -1.0772 &  0.3361 & -0.9042 &  3.1649\\\\\n",
       "\t6908 &  0.20305002 &  1.6617 & -0.03129999 &  0.27434999 &  0.650349975 & -0.19393554 & -0.39605001 &  0.2097500 &  0.72994995 &  0.24660000 & ⋯ & -2.6201 &  0.3546 & -0.8340 &  0.1707 &  0.7447 &  0.8058 & -0.3623 & -1.9207 &  0.1919 & -1.5016\\\\\n",
       "\t672 &  0.32475001 & -4.0764 & -3.70605016 &  0.08045001 & -0.453600019 & -0.40477309 &  0.57854998 &  0.4603500 & -0.35640001 & -0.57574999 & ⋯ & -0.0347 &  0.5236 & -1.3417 &  0.5860 &  0.7067 & -0.6479 &  2.8601 &  2.8988 & -0.1277 &  0.1526\\\\\n",
       "\t5710 &  0.63964999 &  0.2391 &  0.23535000 & -1.49465001 & -1.058050036 & -1.23082113 &  0.30835003 & -1.5607500 & -1.05330002 &  1.03775001 & ⋯ & -0.8548 &  0.0244 & -0.4195 &  0.8007 &  0.8163 & -0.6469 &  2.6838 & -0.4705 & -1.5872 & -1.9920\\\\\n",
       "\t2115 & -0.46765000 &  2.5311 &  0.92490000 &  0.27040002 & -0.008450001 &  1.54992425 &  0.02805001 &  0.9752501 & -0.80159998 & -0.07155001 & ⋯ &  1.7185 &  0.0407 &  0.8669 & -2.4175 & -1.3462 &  0.1283 & -0.6444 &  0.9818 & -0.0399 &  0.1548\\\\\n",
       "\t7015 & -0.62810004 &  2.9025 &  1.92159998 &  0.28770000 &  0.454999983 &  1.53958702 &  0.56625003 &  0.9501500 & -0.29589999 & -0.62774998 & ⋯ &  1.2487 &  0.5907 &  0.8714 &  0.6421 & -0.9362 & -0.4963 & -0.4187 &  0.6203 & -0.1979 &  3.4552\\\\\n",
       "\t8726 &  0.46415001 & -3.4828 & -2.23075008 &  0.99154997 &  0.230650008 &  0.27298701 &  0.02245000 & -0.7093000 & -0.07795000 & -0.39450002 & ⋯ & -1.6259 & -0.1834 & -0.9279 & -5.2129 & -0.4035 &  0.8041 &  1.4548 &  1.4854 &  1.7362 &  1.4854\\\\\n",
       "\t2185 & -0.59829998 & -2.5377 &  4.76999998 & -0.27070001 & -2.783349991 &  1.25042439 & -0.24249998 & -3.3810499 & -0.36440000 &  0.63944995 & ⋯ &  2.5788 &  1.2502 &  1.2122 &  0.2189 & -0.3260 & -0.4259 & -0.4624 &  1.4268 & -1.4473 &  2.8440\\\\\n",
       "\t3315 & -0.22889999 & -1.1686 &  1.73409986 &  0.21175002 & -3.493849993 &  0.21799627 & -0.32495001 & -2.3188000 & -0.12619999 & -0.08780000 & ⋯ &  0.0000 & -0.5599 & -0.7747 &  0.9959 & -0.9554 & -0.6129 &  2.3237 & -0.7365 & -0.4083 & -3.0874\\\\\n",
       "\t5289 &  0.04359999 &  3.6465 &  3.03125000 &  0.90630001 &  0.187049985 &  3.19396544 & -0.23465000 &  1.0276000 & -0.56045002 & -0.05330001 & ⋯ &  0.8281 & -0.9206 &  0.6822 & -0.9480 & -0.2322 & -1.1048 &  0.8300 &  0.4654 & -0.5206 &  0.6745\\\\\n",
       "\t868 &  0.10220000 &  0.8592 &  1.81244993 & -0.25509998 &  0.549250007 & -0.19470868 & -0.59965003 &  0.4235500 & -0.48370001 & -1.28314996 & ⋯ &  0.1421 &  0.7650 &  0.4446 &  0.2584 &  0.1067 &  0.5922 &  1.3067 & -0.8527 & -0.3135 &  0.8328\\\\\n",
       "\t1677 & -0.20805000 &  0.7930 &  1.97329998 &  0.54895002 & -0.111049995 &  1.75220299 & -0.52419996 &  0.9599000 & -0.76335001 & -0.10170000 & ⋯ &  0.3969 &  0.9042 &  0.0418 &  0.4508 &  0.3277 &  4.0569 & -3.5420 & -0.8606 & -0.0633 &  2.4948\\\\\n",
       "\t7043 & -0.27850002 &  2.4205 &  0.82440001 & -0.50725001 &  1.212399960 & -0.33966029 & -0.46219999 &  0.2445500 & -0.48930001 &  0.63644999 & ⋯ &  0.0147 &  1.1314 &  1.5184 &  1.1396 & -0.7535 & -0.1550 & -0.5552 &  0.9483 &  0.5121 &  0.9929\\\\\n",
       "\t5613 & -0.66865003 &  0.5340 &  3.83539987 &  0.60944998 & -1.195199966 &  1.74077058 & -0.14775001 & -0.1435000 &  0.24705002 &  0.45889997 & ⋯ &  0.0717 &  0.5023 &  0.3477 & -2.3664 & -0.3586 & -0.3032 & -0.4723 & -0.3586 & -0.7751 &  1.1149\\\\\n",
       "\t⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋱ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮\\\\\n",
       "\t54552 & -0.547550023 &  0.5666 &  0.74390000 & -0.32515001 &  1.286950111 &  0.6714719 & -0.372799993 &  1.4985501 & -0.04715000 & -0.15339999 & ⋯ &  1.8504 & -0.2516 &  1.3114 & -0.1993 & -1.4090 & -0.4407 & -2.0924 &  0.6877 &  0.7649 & -0.1186\\\\\n",
       "\t54920 & -0.190850005 &  2.6847 &  0.61905003 &  0.51645005 & -0.408650011 &  1.7125645 & -0.076900005 & -0.5360000 & -1.17120004 &  0.30594999 & ⋯ &  0.4583 &  0.8514 &  0.3027 &  1.4400 & -1.0779 & -0.6745 &  0.0638 &  0.4723 &  0.0850 &  0.7503\\\\\n",
       "\t11178 & -0.007799983 &  1.4589 &  0.63424999 & -0.62494999 &  0.307300001 & -0.3424515 & -0.897199988 &  0.0240500 & -0.16354999 &  0.00515002 & ⋯ & -1.7519 &  0.3908 & -1.0155 & -0.2487 & -0.6887 & -0.6171 & -0.5462 & -0.1172 & -1.4105 &  0.1631\\\\\n",
       "\t93643 & -0.781599998 &  0.9777 &  2.61190009 &  0.64004999 &  0.713050008 &  0.9237132 &  0.206200004 &  0.4028500 &  0.18150002 & -1.33759999 & ⋯ &  2.1395 & -0.4617 &  1.2257 &  0.0263 & -1.3893 & -1.9883 &  0.7824 &  0.2161 & -0.5916 &  2.0450\\\\\n",
       "\t112869 & -0.174050003 &  0.1336 & -0.16070001 &  0.83440006 &  0.434750021 &  0.5052795 &  0.133000001 & -0.2637000 & -0.80325001 & -0.37760001 & ⋯ &  2.3786 &  1.1703 &  1.1386 &  0.7210 & -0.1182 & -0.0510 & -1.0956 &  0.8456 & -0.5989 &  1.1402\\\\\n",
       "\t51147 & -0.131500006 &  2.5702 &  2.79585004 &  0.60960001 &  1.184949994 &  0.1883786 & -0.194200009 &  0.8002999 & -0.16949999 &  0.07554999 & ⋯ &  1.9107 &  1.5612 &  0.3518 &  1.2840 & -1.4728 & -0.3504 &  0.0130 &  0.4459 & -0.4840 &  0.9162\\\\\n",
       "\t196403 & -0.179949999 &  3.3629 &  2.99699998 &  1.06465006 &  0.325349987 &  1.2875153 & -0.328400016 &  1.8518502 & -0.13325000 & -1.07975006 & ⋯ &  1.4798 &  0.1850 &  1.3844 &  0.3240 & -0.4564 &  0.3414 &  0.1307 &  0.2026 & -1.4586 &  1.7090\\\\\n",
       "\t389677 & -0.299800009 & -1.7546 &  1.62085009 &  0.17885001 &  0.346049994 &  2.1395676 &  0.425999999 &  0.2757500 & -0.60355002 & -0.66229999 & ⋯ &  0.6175 & -0.6872 &  1.1080 & -0.3949 & -0.7650 &  0.6032 & -0.5789 &  0.8575 &  1.2912 & -0.5854\\\\\n",
       "\t1296 & -0.568499982 &  4.0283 &  1.80404997 &  0.68540001 &  1.193750024 & -0.3998278 & -0.204600006 &  2.2550499 &  0.10470000 &  0.11945000 & ⋯ &  0.9755 &  0.6923 & -0.1845 &  0.1797 & -0.0929 &  0.0885 &  0.6156 &  0.2872 & -0.6606 &  0.7912\\\\\n",
       "\t85352 & -0.582249999 &  2.8892 &  2.65304995 &  0.62145001 &  0.426599979 &  1.1645755 &  0.086000010 &  1.2165500 &  0.69494998 & -0.19315001 & ⋯ & -0.0009 &  3.7638 &  1.6589 &  0.1591 & -0.6720 & -1.0518 & -1.5408 & -0.1605 &  0.1139 &  2.4243\\\\\n",
       "\t57610 &  0.498400003 &  5.1220 &  2.16345000 &  0.01574999 &  0.200550005 &  0.1731201 & -0.926600039 &  0.0807500 & -0.57225001 &  0.07119998 & ⋯ &  1.5447 & -0.0599 &  1.6722 &  0.2858 &  1.6272 & -0.8244 &  0.9907 &  0.4710 &  0.1368 &  1.4276\\\\\n",
       "\t27147 & -0.202250004 &  2.5838 &  1.67175007 & -0.22469999 &  1.058600068 &  0.6260329 & -0.410300016 &  0.1346500 & -0.54540002 & -0.01105000 & ⋯ &  1.3721 & -0.4534 & -0.3415 &  0.3251 & -1.3887 &  0.4315 &  0.1750 & -0.6396 & -1.0847 &  1.3937\\\\\n",
       "\t79591 &  1.026950002 &  2.7480 & -0.06799999 &  0.64854997 &  1.501299977 &  1.2647009 &  0.523100019 & -0.0559500 &  0.24710000 &  0.37870002 & ⋯ &  2.1479 &  1.1361 & -0.7604 &  1.6378 & -0.0226 &  0.0510 & -0.0003 & -0.4592 &  0.8158 &  1.6554\\\\\n",
       "\t92595 &  0.652800024 & -0.7214 &  0.21370000 &  0.66485000 &  1.284350038 &  0.5647974 &  0.559400022 &  1.5563999 &  0.02030000 & -0.36090001 & ⋯ &  0.3339 &  1.3473 &  0.0010 &  0.0615 & -0.2524 &  0.0479 & -0.3532 & -0.2950 &  0.0858 &  0.1184\\\\\n",
       "\t51063 &  0.343500018 & -0.8015 &  0.33515000 &  1.91869998 &  0.368699998 &  0.5586674 & -0.298150003 &  0.2594000 &  0.28309998 &  0.09540004 & ⋯ &  0.9597 &  1.8933 &  1.1444 &  0.9759 & -0.1300 & -0.5763 & -0.3481 & -1.0736 & -0.0896 &  1.2923\\\\\n",
       "\t55223 & -0.215350002 &  4.3713 &  1.97140002 &  0.29425001 &  1.258400083 &  0.8483824 &  0.505299985 &  0.4320000 & -0.73879999 & -1.00734997 & ⋯ & -0.7425 &  1.5926 &  0.3204 &  0.3486 & -1.2565 & -0.0055 & -0.3076 & -0.5895 & -0.6759 &  1.1372\\\\\n",
       "\t80022 & -0.499350011 &  3.3540 &  2.46420002 &  0.21785000 & -0.007000007 &  1.1016043 &  0.208849996 & -0.3577000 & -0.80614996 &  0.93999994 & ⋯ &  1.0909 &  0.1379 &  0.6538 &  0.9385 & -0.8598 & -0.1190 & -1.1109 &  0.0832 & -0.2971 &  0.8936\\\\\n",
       "\t55589 &  0.989849985 & -1.7614 & -0.52405000 & -0.53944999 &  2.766950130 & -1.4092908 &  0.037900001 &  0.5296500 &  0.20385003 & -0.57599998 & ⋯ & -1.7398 &  1.1566 & -0.5645 &  1.4264 &  1.8400 & -0.1273 &  1.2060 &  0.2184 &  1.3779 & -0.5626\\\\\n",
       "\t376267 & -0.697149992 &  1.8690 &  0.45809996 & -0.03180003 &  1.338700056 & -0.2823215 & -0.157900006 &  1.0916001 & -0.20415001 & -0.42180002 & ⋯ &  0.1199 &  1.2685 &  0.9052 &  0.0267 &  0.0809 & -1.1636 &  0.2976 &  1.9446 & -0.9014 &  1.8036\\\\\n",
       "\t84820 & -0.152749985 &  1.8001 &  1.37894988 &  0.01440001 &  1.192999959 &  1.6359860 & -0.251900017 &  1.5041499 & -0.12639999 & -0.49724999 & ⋯ &  1.1424 & -0.0597 &  0.7671 &  0.5935 & -0.5742 & -1.0844 & -0.5707 &  2.0601 & -0.2694 &  1.1255\\\\\n",
       "\t2931 & -0.489800006 &  4.3996 &  2.27640009 &  0.27145001 & -0.035150021 &  0.5720488 & -0.576700032 &  0.1173000 & -0.68005002 &  0.33640003 & ⋯ &  0.2727 &  0.5013 &  0.8471 &  0.2688 &  0.7681 & -0.5762 & -0.8154 & -0.0992 & -0.7370 &  1.7226\\\\\n",
       "\t63876 & -0.252000004 &  2.4605 &  1.21990001 & -0.08165000 &  1.008049965 &  0.7371939 & -0.005400002 &  0.2307501 & -0.44770002 & -0.46705002 & ⋯ & -0.7579 & -0.6265 &  0.8404 & -0.2692 &  0.8911 & -0.2046 & -0.8071 & -0.1506 & -1.6715 &  0.9172\\\\\n",
       "\t51275 & -0.829549968 &  2.4557 &  2.40814996 &  0.42320001 & -0.335050017 & -0.9146695 &  0.963299990 &  1.4400499 &  0.39770001 &  0.27579999 & ⋯ &  0.3883 &  0.6793 &  0.3237 & -0.4276 &  0.7665 &  0.5685 & -1.0498 &  1.5715 & -1.7042 & -0.0870\\\\\n",
       "\t158747 & -0.933599949 &  2.2661 &  2.48624992 &  1.50850010 & -1.788749933 & -0.1306736 & -0.646350026 & -1.1307499 &  0.18900004 &  1.36570001 & ⋯ &  2.4502 &  1.9125 &  0.2526 &  0.5455 &  0.1402 & -0.9180 & -1.9362 &  1.3076 & -0.5795 &  0.3890\\\\\n",
       "\t283232 & -0.549999952 &  1.0838 &  0.41525000 & -0.09474999 &  1.855700016 & -0.2727659 & -0.094699994 &  1.7906501 & -0.75310004 &  0.58985001 & ⋯ &  0.3257 &  1.1194 &  0.5754 & -0.4345 & -3.3375 &  0.5196 & -1.5637 &  1.1416 &  0.2517 & -0.1119\\\\\n",
       "\t25960 &  0.060000002 &  1.8776 &  0.34240001 & -0.22815000 &  1.623250008 & -0.5708635 &  0.072649986 &  0.1602500 &  0.26474997 &  0.05900000 & ⋯ &  0.8320 & -0.3680 &  0.6608 & -0.2463 & -2.4105 &  0.1107 & -0.2676 &  0.6119 &  1.1775 &  0.9155\\\\\n",
       "\t6376 & -0.391449988 &  2.0942 &  1.54129994 &  0.29714999 & -0.322299987 &  0.6695740 &  0.684000015 & -0.2364000 & -0.22969997 & -1.19679999 & ⋯ &  1.1901 & -0.0144 &  1.5630 &  0.3335 &  1.0411 & -1.1291 &  0.6466 &  1.4029 & -1.0273 &  0.0192\\\\\n",
       "\t11033 & -0.816999972 &  0.0360 &  1.86659992 &  1.18130004 & -1.078150034 &  2.5671935 & -0.160849988 &  0.1246000 &  1.15509999 &  0.12650001 & ⋯ &  1.2484 & -0.1491 &  0.0777 &  0.3478 & -0.7770 & -0.2837 & -0.0944 &  0.7815 & -0.3094 &  2.2588\\\\\n",
       "\t54869 & -0.491949975 &  3.9373 &  2.89374995 &  0.08510001 & -1.110100031 &  1.1950539 & -0.178350002 &  1.4240000 & -0.01594999 &  1.36944997 & ⋯ & -0.1743 &  1.0657 &  0.7791 &  1.0932 & -0.5247 & -0.5104 & -0.2863 & -0.5035 &  1.2087 &  2.5072\\\\\n",
       "\t60 & -0.487500012 & -0.0225 & -0.53219998 & -0.72780001 & -0.636449993 & -0.1309013 & -0.509249985 & -0.4348000 &  0.53165001 &  0.25479999 & ⋯ & -1.4556 & -0.2475 & -0.6307 & -0.2042 &  0.7773 &  0.3077 &  1.8114 & -1.0285 &  0.0535 & -1.3198\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A matrix: 12328 × 45956 of type dbl\n",
       "\n",
       "| <!--/--> | BRD-A03772856__CD34__trt_cp | trichostatin-a__CD34__trt_cp | geldanamycin__CD34__trt_cp | KUC107191N__CD34__trt_cp | BRD-A35207501__CD34__trt_cp | iloprost__CD34__trt_cp | BRD-A72498772__CD34__trt_cp | BRD-A72796238__CD34__trt_cp | BRD-A73513677__CD34__trt_cp | BRD-A73558769__CD34__trt_cp | ⋯ | MW-MITF24__MCF7__trt_cp | l-buthionine-sulfoximine__PC3__trt_cp | alpha-tocopherol__PC3__trt_cp | cisplatin__PC3__trt_cp | iniparib__PC3__trt_cp | JMW-MITF1__PC3__trt_cp | bortezomib__PC3__trt_cp | selumetinib__PC3__trt_cp | glutamine__PC3__trt_cp | MW-MITF24__PC3__trt_cp |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| 5720 |  0.36540002 | -1.9333 | -1.78014994 | -0.61925000 | -0.729250073 | -2.01719809 |  0.18455000 | -1.1793000 |  0.34680000 |  0.10225001 | ⋯ | -2.1606 | -0.2913 | -1.2731 | -0.5659 |  0.4571 |  0.0308 | -0.2913 | -0.9489 | -1.0550 | -1.9929 |\n",
       "| 466 |  0.69385004 | -4.0653 | -2.45910001 |  0.05739999 |  1.069949985 | -1.52120280 | -0.19575000 |  1.3569000 |  0.32670000 |  0.36719999 | ⋯ | -1.9576 | -0.6859 |  0.5907 | -0.2468 |  0.7582 |  0.4957 | -1.0830 |  0.3153 |  1.3292 | -0.5015 |\n",
       "| 6009 |  0.55435002 |  0.1850 |  0.22250000 |  0.05124998 |  0.336199999 | -1.32433784 |  0.78560001 | -0.2471000 |  1.50240004 | -0.47415000 | ⋯ | -1.9373 | -0.7577 | -1.8149 |  0.0000 |  0.3941 | -1.6190 |  0.1462 | -2.1747 | -0.2952 | -2.1053 |\n",
       "| 2309 | -0.31579998 |  2.2660 |  0.67035002 | -0.39039999 |  1.141200066 |  0.91430640 |  0.45165002 |  0.1099000 | -0.58609998 | -1.34329998 | ⋯ |  0.9808 | -0.0848 | -1.5376 |  0.6194 | -0.2978 |  0.5139 |  2.9324 | -0.9933 | -0.0140 | -1.1789 |\n",
       "| 387 |  0.37180001 | -0.2558 | -2.59875011 | -2.12490010 |  1.495700002 | -3.34633827 | -0.03835000 | -0.9017001 |  1.18655002 |  0.68274999 | ⋯ | -1.5168 |  0.0997 | -0.3862 |  0.1973 | -0.4246 | -0.5682 |  0.6157 | -0.3696 |  0.3436 | -3.2787 |\n",
       "| 3553 |  0.70824999 | -0.5149 | -0.73619998 | -0.41515002 |  1.960999966 |  0.22129090 | -0.20070001 |  0.8321000 |  2.93820000 | -0.08945002 | ⋯ |  3.2767 |  0.0000 | -0.1367 | -0.6745 | -1.0342 | -1.3800 | -0.9713 |  1.2338 | -1.3174 | -0.6564 |\n",
       "| 427 |  0.18295000 | -1.6045 |  0.42860001 |  0.30954999 |  1.228850007 |  0.06338993 |  0.44700000 |  0.3969500 |  0.57410002 | -0.11010003 | ⋯ |  0.5427 | -0.5669 | -0.7753 | -0.8029 |  1.6375 |  1.7251 |  1.2290 |  0.0243 | -0.7690 | -0.6058 |\n",
       "| 5898 | -0.40434998 |  3.5042 |  2.97979999 | -0.84810001 |  1.905500054 |  0.31654096 | -0.01730000 | -0.1905500 | -0.82900000 | -0.52789998 | ⋯ | -0.3057 |  0.1609 |  0.2776 |  0.0750 | -2.8649 |  0.5809 |  1.7948 | -0.0093 |  1.2902 |  0.2903 |\n",
       "| 23365 |  0.49500000 |  0.4630 |  0.48894998 | -0.25070000 |  0.521200001 | -0.62915254 | -0.67110002 | -0.7869500 |  0.49564999 |  1.38380003 | ⋯ | -0.7719 | -0.3665 |  0.7769 |  0.3405 | -0.6687 |  0.4276 | -2.5250 |  0.0963 |  0.0482 |  0.0963 |\n",
       "| 6657 | -0.58120000 |  2.3181 |  1.18390000 |  0.32394999 |  0.963199973 |  1.12940836 | -0.09670001 |  1.5269001 | -0.28994998 | -0.26674998 | ⋯ |  2.3400 |  0.8720 |  1.4368 |  0.5604 | -1.3073 | -0.8898 | -0.4415 |  0.7747 | -0.3321 |  2.5004 |\n",
       "| 5054 | -0.25055000 | -0.2075 | -0.43175000 |  0.16700003 |  1.369400024 |  1.35352969 | -0.11345001 |  0.5116500 | -0.07969996 | -0.21934998 | ⋯ |  0.6593 |  0.2299 |  0.5751 |  0.2370 |  0.4596 |  0.3050 | -1.6550 |  0.0137 |  0.4267 |  0.6745 |\n",
       "| 3108 | -0.06060000 | -1.8116 | -1.61284995 | -0.08275000 | -0.534399986 | -0.13355637 | -0.01085000 | -1.5620000 |  0.59775001 |  0.97039998 | ⋯ |  0.6745 |  0.3049 | -0.5842 | -0.3346 |  1.3939 | -0.4618 |  0.4915 |  0.0590 |  0.1180 |  1.7550 |\n",
       "| 1950 |  0.34324998 | -0.3875 |  1.33039999 |  0.69085002 | -1.051300049 |  3.66408134 |  0.38674998 |  2.6680501 | -0.73095000 | -0.51055002 | ⋯ |  0.8943 |  0.2505 |  1.1675 | -0.0811 | -0.4084 | -0.6610 | -0.0670 |  1.3110 | -1.1154 |  2.5754 |\n",
       "| 351 | -0.75015002 |  0.0000 |  1.67859995 |  0.01835000 |  0.958649993 |  0.42959470 |  0.31160000 |  0.9131501 |  0.33724999 | -0.51849997 | ⋯ |  1.2067 |  0.8746 | -1.4754 |  0.3245 |  1.2609 |  0.4734 |  1.3987 | -0.1130 | -0.8090 |  0.3988 |\n",
       "| 4846 |  0.44309998 |  2.6904 |  1.82799995 |  0.63379997 |  0.361950010 |  1.81054175 |  0.38900000 |  3.5537500 | -0.76929998 | -0.95864999 | ⋯ | -1.2723 |  1.0611 |  0.0000 |  0.8742 |  0.5819 |  0.4788 |  1.4877 | -0.3579 | -0.6335 | -0.7591 |\n",
       "| 1452 |  0.05585000 | -0.3123 |  0.57295001 | -0.44580001 |  0.636549950 | -0.72561306 | -3.03379989 | -0.7344500 |  0.70099998 |  0.10130000 | ⋯ | -1.9790 |  0.3489 | -0.7107 | -1.8170 |  0.3777 | -1.1747 |  1.5557 | -0.0845 | -1.1233 | -1.5332 |\n",
       "| 4776 | -0.92770004 |  0.6834 |  2.35645008 |  1.05629992 | -0.044949993 |  0.66652113 | -0.03335000 |  2.2428999 |  0.25165001 |  0.55704999 | ⋯ |  3.3373 |  0.5311 |  1.3320 |  0.3057 | -0.9554 | -0.9277 | -1.0772 |  0.3361 | -0.9042 |  3.1649 |\n",
       "| 6908 |  0.20305002 |  1.6617 | -0.03129999 |  0.27434999 |  0.650349975 | -0.19393554 | -0.39605001 |  0.2097500 |  0.72994995 |  0.24660000 | ⋯ | -2.6201 |  0.3546 | -0.8340 |  0.1707 |  0.7447 |  0.8058 | -0.3623 | -1.9207 |  0.1919 | -1.5016 |\n",
       "| 672 |  0.32475001 | -4.0764 | -3.70605016 |  0.08045001 | -0.453600019 | -0.40477309 |  0.57854998 |  0.4603500 | -0.35640001 | -0.57574999 | ⋯ | -0.0347 |  0.5236 | -1.3417 |  0.5860 |  0.7067 | -0.6479 |  2.8601 |  2.8988 | -0.1277 |  0.1526 |\n",
       "| 5710 |  0.63964999 |  0.2391 |  0.23535000 | -1.49465001 | -1.058050036 | -1.23082113 |  0.30835003 | -1.5607500 | -1.05330002 |  1.03775001 | ⋯ | -0.8548 |  0.0244 | -0.4195 |  0.8007 |  0.8163 | -0.6469 |  2.6838 | -0.4705 | -1.5872 | -1.9920 |\n",
       "| 2115 | -0.46765000 |  2.5311 |  0.92490000 |  0.27040002 | -0.008450001 |  1.54992425 |  0.02805001 |  0.9752501 | -0.80159998 | -0.07155001 | ⋯ |  1.7185 |  0.0407 |  0.8669 | -2.4175 | -1.3462 |  0.1283 | -0.6444 |  0.9818 | -0.0399 |  0.1548 |\n",
       "| 7015 | -0.62810004 |  2.9025 |  1.92159998 |  0.28770000 |  0.454999983 |  1.53958702 |  0.56625003 |  0.9501500 | -0.29589999 | -0.62774998 | ⋯ |  1.2487 |  0.5907 |  0.8714 |  0.6421 | -0.9362 | -0.4963 | -0.4187 |  0.6203 | -0.1979 |  3.4552 |\n",
       "| 8726 |  0.46415001 | -3.4828 | -2.23075008 |  0.99154997 |  0.230650008 |  0.27298701 |  0.02245000 | -0.7093000 | -0.07795000 | -0.39450002 | ⋯ | -1.6259 | -0.1834 | -0.9279 | -5.2129 | -0.4035 |  0.8041 |  1.4548 |  1.4854 |  1.7362 |  1.4854 |\n",
       "| 2185 | -0.59829998 | -2.5377 |  4.76999998 | -0.27070001 | -2.783349991 |  1.25042439 | -0.24249998 | -3.3810499 | -0.36440000 |  0.63944995 | ⋯ |  2.5788 |  1.2502 |  1.2122 |  0.2189 | -0.3260 | -0.4259 | -0.4624 |  1.4268 | -1.4473 |  2.8440 |\n",
       "| 3315 | -0.22889999 | -1.1686 |  1.73409986 |  0.21175002 | -3.493849993 |  0.21799627 | -0.32495001 | -2.3188000 | -0.12619999 | -0.08780000 | ⋯ |  0.0000 | -0.5599 | -0.7747 |  0.9959 | -0.9554 | -0.6129 |  2.3237 | -0.7365 | -0.4083 | -3.0874 |\n",
       "| 5289 |  0.04359999 |  3.6465 |  3.03125000 |  0.90630001 |  0.187049985 |  3.19396544 | -0.23465000 |  1.0276000 | -0.56045002 | -0.05330001 | ⋯ |  0.8281 | -0.9206 |  0.6822 | -0.9480 | -0.2322 | -1.1048 |  0.8300 |  0.4654 | -0.5206 |  0.6745 |\n",
       "| 868 |  0.10220000 |  0.8592 |  1.81244993 | -0.25509998 |  0.549250007 | -0.19470868 | -0.59965003 |  0.4235500 | -0.48370001 | -1.28314996 | ⋯ |  0.1421 |  0.7650 |  0.4446 |  0.2584 |  0.1067 |  0.5922 |  1.3067 | -0.8527 | -0.3135 |  0.8328 |\n",
       "| 1677 | -0.20805000 |  0.7930 |  1.97329998 |  0.54895002 | -0.111049995 |  1.75220299 | -0.52419996 |  0.9599000 | -0.76335001 | -0.10170000 | ⋯ |  0.3969 |  0.9042 |  0.0418 |  0.4508 |  0.3277 |  4.0569 | -3.5420 | -0.8606 | -0.0633 |  2.4948 |\n",
       "| 7043 | -0.27850002 |  2.4205 |  0.82440001 | -0.50725001 |  1.212399960 | -0.33966029 | -0.46219999 |  0.2445500 | -0.48930001 |  0.63644999 | ⋯ |  0.0147 |  1.1314 |  1.5184 |  1.1396 | -0.7535 | -0.1550 | -0.5552 |  0.9483 |  0.5121 |  0.9929 |\n",
       "| 5613 | -0.66865003 |  0.5340 |  3.83539987 |  0.60944998 | -1.195199966 |  1.74077058 | -0.14775001 | -0.1435000 |  0.24705002 |  0.45889997 | ⋯ |  0.0717 |  0.5023 |  0.3477 | -2.3664 | -0.3586 | -0.3032 | -0.4723 | -0.3586 | -0.7751 |  1.1149 |\n",
       "| ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋱ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ |\n",
       "| 54552 | -0.547550023 |  0.5666 |  0.74390000 | -0.32515001 |  1.286950111 |  0.6714719 | -0.372799993 |  1.4985501 | -0.04715000 | -0.15339999 | ⋯ |  1.8504 | -0.2516 |  1.3114 | -0.1993 | -1.4090 | -0.4407 | -2.0924 |  0.6877 |  0.7649 | -0.1186 |\n",
       "| 54920 | -0.190850005 |  2.6847 |  0.61905003 |  0.51645005 | -0.408650011 |  1.7125645 | -0.076900005 | -0.5360000 | -1.17120004 |  0.30594999 | ⋯ |  0.4583 |  0.8514 |  0.3027 |  1.4400 | -1.0779 | -0.6745 |  0.0638 |  0.4723 |  0.0850 |  0.7503 |\n",
       "| 11178 | -0.007799983 |  1.4589 |  0.63424999 | -0.62494999 |  0.307300001 | -0.3424515 | -0.897199988 |  0.0240500 | -0.16354999 |  0.00515002 | ⋯ | -1.7519 |  0.3908 | -1.0155 | -0.2487 | -0.6887 | -0.6171 | -0.5462 | -0.1172 | -1.4105 |  0.1631 |\n",
       "| 93643 | -0.781599998 |  0.9777 |  2.61190009 |  0.64004999 |  0.713050008 |  0.9237132 |  0.206200004 |  0.4028500 |  0.18150002 | -1.33759999 | ⋯ |  2.1395 | -0.4617 |  1.2257 |  0.0263 | -1.3893 | -1.9883 |  0.7824 |  0.2161 | -0.5916 |  2.0450 |\n",
       "| 112869 | -0.174050003 |  0.1336 | -0.16070001 |  0.83440006 |  0.434750021 |  0.5052795 |  0.133000001 | -0.2637000 | -0.80325001 | -0.37760001 | ⋯ |  2.3786 |  1.1703 |  1.1386 |  0.7210 | -0.1182 | -0.0510 | -1.0956 |  0.8456 | -0.5989 |  1.1402 |\n",
       "| 51147 | -0.131500006 |  2.5702 |  2.79585004 |  0.60960001 |  1.184949994 |  0.1883786 | -0.194200009 |  0.8002999 | -0.16949999 |  0.07554999 | ⋯ |  1.9107 |  1.5612 |  0.3518 |  1.2840 | -1.4728 | -0.3504 |  0.0130 |  0.4459 | -0.4840 |  0.9162 |\n",
       "| 196403 | -0.179949999 |  3.3629 |  2.99699998 |  1.06465006 |  0.325349987 |  1.2875153 | -0.328400016 |  1.8518502 | -0.13325000 | -1.07975006 | ⋯ |  1.4798 |  0.1850 |  1.3844 |  0.3240 | -0.4564 |  0.3414 |  0.1307 |  0.2026 | -1.4586 |  1.7090 |\n",
       "| 389677 | -0.299800009 | -1.7546 |  1.62085009 |  0.17885001 |  0.346049994 |  2.1395676 |  0.425999999 |  0.2757500 | -0.60355002 | -0.66229999 | ⋯ |  0.6175 | -0.6872 |  1.1080 | -0.3949 | -0.7650 |  0.6032 | -0.5789 |  0.8575 |  1.2912 | -0.5854 |\n",
       "| 1296 | -0.568499982 |  4.0283 |  1.80404997 |  0.68540001 |  1.193750024 | -0.3998278 | -0.204600006 |  2.2550499 |  0.10470000 |  0.11945000 | ⋯ |  0.9755 |  0.6923 | -0.1845 |  0.1797 | -0.0929 |  0.0885 |  0.6156 |  0.2872 | -0.6606 |  0.7912 |\n",
       "| 85352 | -0.582249999 |  2.8892 |  2.65304995 |  0.62145001 |  0.426599979 |  1.1645755 |  0.086000010 |  1.2165500 |  0.69494998 | -0.19315001 | ⋯ | -0.0009 |  3.7638 |  1.6589 |  0.1591 | -0.6720 | -1.0518 | -1.5408 | -0.1605 |  0.1139 |  2.4243 |\n",
       "| 57610 |  0.498400003 |  5.1220 |  2.16345000 |  0.01574999 |  0.200550005 |  0.1731201 | -0.926600039 |  0.0807500 | -0.57225001 |  0.07119998 | ⋯ |  1.5447 | -0.0599 |  1.6722 |  0.2858 |  1.6272 | -0.8244 |  0.9907 |  0.4710 |  0.1368 |  1.4276 |\n",
       "| 27147 | -0.202250004 |  2.5838 |  1.67175007 | -0.22469999 |  1.058600068 |  0.6260329 | -0.410300016 |  0.1346500 | -0.54540002 | -0.01105000 | ⋯ |  1.3721 | -0.4534 | -0.3415 |  0.3251 | -1.3887 |  0.4315 |  0.1750 | -0.6396 | -1.0847 |  1.3937 |\n",
       "| 79591 |  1.026950002 |  2.7480 | -0.06799999 |  0.64854997 |  1.501299977 |  1.2647009 |  0.523100019 | -0.0559500 |  0.24710000 |  0.37870002 | ⋯ |  2.1479 |  1.1361 | -0.7604 |  1.6378 | -0.0226 |  0.0510 | -0.0003 | -0.4592 |  0.8158 |  1.6554 |\n",
       "| 92595 |  0.652800024 | -0.7214 |  0.21370000 |  0.66485000 |  1.284350038 |  0.5647974 |  0.559400022 |  1.5563999 |  0.02030000 | -0.36090001 | ⋯ |  0.3339 |  1.3473 |  0.0010 |  0.0615 | -0.2524 |  0.0479 | -0.3532 | -0.2950 |  0.0858 |  0.1184 |\n",
       "| 51063 |  0.343500018 | -0.8015 |  0.33515000 |  1.91869998 |  0.368699998 |  0.5586674 | -0.298150003 |  0.2594000 |  0.28309998 |  0.09540004 | ⋯ |  0.9597 |  1.8933 |  1.1444 |  0.9759 | -0.1300 | -0.5763 | -0.3481 | -1.0736 | -0.0896 |  1.2923 |\n",
       "| 55223 | -0.215350002 |  4.3713 |  1.97140002 |  0.29425001 |  1.258400083 |  0.8483824 |  0.505299985 |  0.4320000 | -0.73879999 | -1.00734997 | ⋯ | -0.7425 |  1.5926 |  0.3204 |  0.3486 | -1.2565 | -0.0055 | -0.3076 | -0.5895 | -0.6759 |  1.1372 |\n",
       "| 80022 | -0.499350011 |  3.3540 |  2.46420002 |  0.21785000 | -0.007000007 |  1.1016043 |  0.208849996 | -0.3577000 | -0.80614996 |  0.93999994 | ⋯ |  1.0909 |  0.1379 |  0.6538 |  0.9385 | -0.8598 | -0.1190 | -1.1109 |  0.0832 | -0.2971 |  0.8936 |\n",
       "| 55589 |  0.989849985 | -1.7614 | -0.52405000 | -0.53944999 |  2.766950130 | -1.4092908 |  0.037900001 |  0.5296500 |  0.20385003 | -0.57599998 | ⋯ | -1.7398 |  1.1566 | -0.5645 |  1.4264 |  1.8400 | -0.1273 |  1.2060 |  0.2184 |  1.3779 | -0.5626 |\n",
       "| 376267 | -0.697149992 |  1.8690 |  0.45809996 | -0.03180003 |  1.338700056 | -0.2823215 | -0.157900006 |  1.0916001 | -0.20415001 | -0.42180002 | ⋯ |  0.1199 |  1.2685 |  0.9052 |  0.0267 |  0.0809 | -1.1636 |  0.2976 |  1.9446 | -0.9014 |  1.8036 |\n",
       "| 84820 | -0.152749985 |  1.8001 |  1.37894988 |  0.01440001 |  1.192999959 |  1.6359860 | -0.251900017 |  1.5041499 | -0.12639999 | -0.49724999 | ⋯ |  1.1424 | -0.0597 |  0.7671 |  0.5935 | -0.5742 | -1.0844 | -0.5707 |  2.0601 | -0.2694 |  1.1255 |\n",
       "| 2931 | -0.489800006 |  4.3996 |  2.27640009 |  0.27145001 | -0.035150021 |  0.5720488 | -0.576700032 |  0.1173000 | -0.68005002 |  0.33640003 | ⋯ |  0.2727 |  0.5013 |  0.8471 |  0.2688 |  0.7681 | -0.5762 | -0.8154 | -0.0992 | -0.7370 |  1.7226 |\n",
       "| 63876 | -0.252000004 |  2.4605 |  1.21990001 | -0.08165000 |  1.008049965 |  0.7371939 | -0.005400002 |  0.2307501 | -0.44770002 | -0.46705002 | ⋯ | -0.7579 | -0.6265 |  0.8404 | -0.2692 |  0.8911 | -0.2046 | -0.8071 | -0.1506 | -1.6715 |  0.9172 |\n",
       "| 51275 | -0.829549968 |  2.4557 |  2.40814996 |  0.42320001 | -0.335050017 | -0.9146695 |  0.963299990 |  1.4400499 |  0.39770001 |  0.27579999 | ⋯ |  0.3883 |  0.6793 |  0.3237 | -0.4276 |  0.7665 |  0.5685 | -1.0498 |  1.5715 | -1.7042 | -0.0870 |\n",
       "| 158747 | -0.933599949 |  2.2661 |  2.48624992 |  1.50850010 | -1.788749933 | -0.1306736 | -0.646350026 | -1.1307499 |  0.18900004 |  1.36570001 | ⋯ |  2.4502 |  1.9125 |  0.2526 |  0.5455 |  0.1402 | -0.9180 | -1.9362 |  1.3076 | -0.5795 |  0.3890 |\n",
       "| 283232 | -0.549999952 |  1.0838 |  0.41525000 | -0.09474999 |  1.855700016 | -0.2727659 | -0.094699994 |  1.7906501 | -0.75310004 |  0.58985001 | ⋯ |  0.3257 |  1.1194 |  0.5754 | -0.4345 | -3.3375 |  0.5196 | -1.5637 |  1.1416 |  0.2517 | -0.1119 |\n",
       "| 25960 |  0.060000002 |  1.8776 |  0.34240001 | -0.22815000 |  1.623250008 | -0.5708635 |  0.072649986 |  0.1602500 |  0.26474997 |  0.05900000 | ⋯ |  0.8320 | -0.3680 |  0.6608 | -0.2463 | -2.4105 |  0.1107 | -0.2676 |  0.6119 |  1.1775 |  0.9155 |\n",
       "| 6376 | -0.391449988 |  2.0942 |  1.54129994 |  0.29714999 | -0.322299987 |  0.6695740 |  0.684000015 | -0.2364000 | -0.22969997 | -1.19679999 | ⋯ |  1.1901 | -0.0144 |  1.5630 |  0.3335 |  1.0411 | -1.1291 |  0.6466 |  1.4029 | -1.0273 |  0.0192 |\n",
       "| 11033 | -0.816999972 |  0.0360 |  1.86659992 |  1.18130004 | -1.078150034 |  2.5671935 | -0.160849988 |  0.1246000 |  1.15509999 |  0.12650001 | ⋯ |  1.2484 | -0.1491 |  0.0777 |  0.3478 | -0.7770 | -0.2837 | -0.0944 |  0.7815 | -0.3094 |  2.2588 |\n",
       "| 54869 | -0.491949975 |  3.9373 |  2.89374995 |  0.08510001 | -1.110100031 |  1.1950539 | -0.178350002 |  1.4240000 | -0.01594999 |  1.36944997 | ⋯ | -0.1743 |  1.0657 |  0.7791 |  1.0932 | -0.5247 | -0.5104 | -0.2863 | -0.5035 |  1.2087 |  2.5072 |\n",
       "| 60 | -0.487500012 | -0.0225 | -0.53219998 | -0.72780001 | -0.636449993 | -0.1309013 | -0.509249985 | -0.4348000 |  0.53165001 |  0.25479999 | ⋯ | -1.4556 | -0.2475 | -0.6307 | -0.2042 |  0.7773 |  0.3077 |  1.8114 | -1.0285 |  0.0535 | -1.3198 |\n",
       "\n"
      ],
      "text/plain": [
       "       BRD-A03772856__CD34__trt_cp trichostatin-a__CD34__trt_cp\n",
       "5720    0.36540002                 -1.9333                     \n",
       "466     0.69385004                 -4.0653                     \n",
       "6009    0.55435002                  0.1850                     \n",
       "2309   -0.31579998                  2.2660                     \n",
       "387     0.37180001                 -0.2558                     \n",
       "3553    0.70824999                 -0.5149                     \n",
       "427     0.18295000                 -1.6045                     \n",
       "5898   -0.40434998                  3.5042                     \n",
       "23365   0.49500000                  0.4630                     \n",
       "6657   -0.58120000                  2.3181                     \n",
       "5054   -0.25055000                 -0.2075                     \n",
       "3108   -0.06060000                 -1.8116                     \n",
       "1950    0.34324998                 -0.3875                     \n",
       "351    -0.75015002                  0.0000                     \n",
       "4846    0.44309998                  2.6904                     \n",
       "1452    0.05585000                 -0.3123                     \n",
       "4776   -0.92770004                  0.6834                     \n",
       "6908    0.20305002                  1.6617                     \n",
       "672     0.32475001                 -4.0764                     \n",
       "5710    0.63964999                  0.2391                     \n",
       "2115   -0.46765000                  2.5311                     \n",
       "7015   -0.62810004                  2.9025                     \n",
       "8726    0.46415001                 -3.4828                     \n",
       "2185   -0.59829998                 -2.5377                     \n",
       "3315   -0.22889999                 -1.1686                     \n",
       "5289    0.04359999                  3.6465                     \n",
       "868     0.10220000                  0.8592                     \n",
       "1677   -0.20805000                  0.7930                     \n",
       "7043   -0.27850002                  2.4205                     \n",
       "5613   -0.66865003                  0.5340                     \n",
       "⋮      ⋮                           ⋮                           \n",
       "54552  -0.547550023                 0.5666                     \n",
       "54920  -0.190850005                 2.6847                     \n",
       "11178  -0.007799983                 1.4589                     \n",
       "93643  -0.781599998                 0.9777                     \n",
       "112869 -0.174050003                 0.1336                     \n",
       "51147  -0.131500006                 2.5702                     \n",
       "196403 -0.179949999                 3.3629                     \n",
       "389677 -0.299800009                -1.7546                     \n",
       "1296   -0.568499982                 4.0283                     \n",
       "85352  -0.582249999                 2.8892                     \n",
       "57610   0.498400003                 5.1220                     \n",
       "27147  -0.202250004                 2.5838                     \n",
       "79591   1.026950002                 2.7480                     \n",
       "92595   0.652800024                -0.7214                     \n",
       "51063   0.343500018                -0.8015                     \n",
       "55223  -0.215350002                 4.3713                     \n",
       "80022  -0.499350011                 3.3540                     \n",
       "55589   0.989849985                -1.7614                     \n",
       "376267 -0.697149992                 1.8690                     \n",
       "84820  -0.152749985                 1.8001                     \n",
       "2931   -0.489800006                 4.3996                     \n",
       "63876  -0.252000004                 2.4605                     \n",
       "51275  -0.829549968                 2.4557                     \n",
       "158747 -0.933599949                 2.2661                     \n",
       "283232 -0.549999952                 1.0838                     \n",
       "25960   0.060000002                 1.8776                     \n",
       "6376   -0.391449988                 2.0942                     \n",
       "11033  -0.816999972                 0.0360                     \n",
       "54869  -0.491949975                 3.9373                     \n",
       "60     -0.487500012                -0.0225                     \n",
       "       geldanamycin__CD34__trt_cp KUC107191N__CD34__trt_cp\n",
       "5720   -1.78014994                -0.61925000             \n",
       "466    -2.45910001                 0.05739999             \n",
       "6009    0.22250000                 0.05124998             \n",
       "2309    0.67035002                -0.39039999             \n",
       "387    -2.59875011                -2.12490010             \n",
       "3553   -0.73619998                -0.41515002             \n",
       "427     0.42860001                 0.30954999             \n",
       "5898    2.97979999                -0.84810001             \n",
       "23365   0.48894998                -0.25070000             \n",
       "6657    1.18390000                 0.32394999             \n",
       "5054   -0.43175000                 0.16700003             \n",
       "3108   -1.61284995                -0.08275000             \n",
       "1950    1.33039999                 0.69085002             \n",
       "351     1.67859995                 0.01835000             \n",
       "4846    1.82799995                 0.63379997             \n",
       "1452    0.57295001                -0.44580001             \n",
       "4776    2.35645008                 1.05629992             \n",
       "6908   -0.03129999                 0.27434999             \n",
       "672    -3.70605016                 0.08045001             \n",
       "5710    0.23535000                -1.49465001             \n",
       "2115    0.92490000                 0.27040002             \n",
       "7015    1.92159998                 0.28770000             \n",
       "8726   -2.23075008                 0.99154997             \n",
       "2185    4.76999998                -0.27070001             \n",
       "3315    1.73409986                 0.21175002             \n",
       "5289    3.03125000                 0.90630001             \n",
       "868     1.81244993                -0.25509998             \n",
       "1677    1.97329998                 0.54895002             \n",
       "7043    0.82440001                -0.50725001             \n",
       "5613    3.83539987                 0.60944998             \n",
       "⋮      ⋮                          ⋮                       \n",
       "54552   0.74390000                -0.32515001             \n",
       "54920   0.61905003                 0.51645005             \n",
       "11178   0.63424999                -0.62494999             \n",
       "93643   2.61190009                 0.64004999             \n",
       "112869 -0.16070001                 0.83440006             \n",
       "51147   2.79585004                 0.60960001             \n",
       "196403  2.99699998                 1.06465006             \n",
       "389677  1.62085009                 0.17885001             \n",
       "1296    1.80404997                 0.68540001             \n",
       "85352   2.65304995                 0.62145001             \n",
       "57610   2.16345000                 0.01574999             \n",
       "27147   1.67175007                -0.22469999             \n",
       "79591  -0.06799999                 0.64854997             \n",
       "92595   0.21370000                 0.66485000             \n",
       "51063   0.33515000                 1.91869998             \n",
       "55223   1.97140002                 0.29425001             \n",
       "80022   2.46420002                 0.21785000             \n",
       "55589  -0.52405000                -0.53944999             \n",
       "376267  0.45809996                -0.03180003             \n",
       "84820   1.37894988                 0.01440001             \n",
       "2931    2.27640009                 0.27145001             \n",
       "63876   1.21990001                -0.08165000             \n",
       "51275   2.40814996                 0.42320001             \n",
       "158747  2.48624992                 1.50850010             \n",
       "283232  0.41525000                -0.09474999             \n",
       "25960   0.34240001                -0.22815000             \n",
       "6376    1.54129994                 0.29714999             \n",
       "11033   1.86659992                 1.18130004             \n",
       "54869   2.89374995                 0.08510001             \n",
       "60     -0.53219998                -0.72780001             \n",
       "       BRD-A35207501__CD34__trt_cp iloprost__CD34__trt_cp\n",
       "5720   -0.729250073                -2.01719809           \n",
       "466     1.069949985                -1.52120280           \n",
       "6009    0.336199999                -1.32433784           \n",
       "2309    1.141200066                 0.91430640           \n",
       "387     1.495700002                -3.34633827           \n",
       "3553    1.960999966                 0.22129090           \n",
       "427     1.228850007                 0.06338993           \n",
       "5898    1.905500054                 0.31654096           \n",
       "23365   0.521200001                -0.62915254           \n",
       "6657    0.963199973                 1.12940836           \n",
       "5054    1.369400024                 1.35352969           \n",
       "3108   -0.534399986                -0.13355637           \n",
       "1950   -1.051300049                 3.66408134           \n",
       "351     0.958649993                 0.42959470           \n",
       "4846    0.361950010                 1.81054175           \n",
       "1452    0.636549950                -0.72561306           \n",
       "4776   -0.044949993                 0.66652113           \n",
       "6908    0.650349975                -0.19393554           \n",
       "672    -0.453600019                -0.40477309           \n",
       "5710   -1.058050036                -1.23082113           \n",
       "2115   -0.008450001                 1.54992425           \n",
       "7015    0.454999983                 1.53958702           \n",
       "8726    0.230650008                 0.27298701           \n",
       "2185   -2.783349991                 1.25042439           \n",
       "3315   -3.493849993                 0.21799627           \n",
       "5289    0.187049985                 3.19396544           \n",
       "868     0.549250007                -0.19470868           \n",
       "1677   -0.111049995                 1.75220299           \n",
       "7043    1.212399960                -0.33966029           \n",
       "5613   -1.195199966                 1.74077058           \n",
       "⋮      ⋮                           ⋮                     \n",
       "54552   1.286950111                 0.6714719            \n",
       "54920  -0.408650011                 1.7125645            \n",
       "11178   0.307300001                -0.3424515            \n",
       "93643   0.713050008                 0.9237132            \n",
       "112869  0.434750021                 0.5052795            \n",
       "51147   1.184949994                 0.1883786            \n",
       "196403  0.325349987                 1.2875153            \n",
       "389677  0.346049994                 2.1395676            \n",
       "1296    1.193750024                -0.3998278            \n",
       "85352   0.426599979                 1.1645755            \n",
       "57610   0.200550005                 0.1731201            \n",
       "27147   1.058600068                 0.6260329            \n",
       "79591   1.501299977                 1.2647009            \n",
       "92595   1.284350038                 0.5647974            \n",
       "51063   0.368699998                 0.5586674            \n",
       "55223   1.258400083                 0.8483824            \n",
       "80022  -0.007000007                 1.1016043            \n",
       "55589   2.766950130                -1.4092908            \n",
       "376267  1.338700056                -0.2823215            \n",
       "84820   1.192999959                 1.6359860            \n",
       "2931   -0.035150021                 0.5720488            \n",
       "63876   1.008049965                 0.7371939            \n",
       "51275  -0.335050017                -0.9146695            \n",
       "158747 -1.788749933                -0.1306736            \n",
       "283232  1.855700016                -0.2727659            \n",
       "25960   1.623250008                -0.5708635            \n",
       "6376   -0.322299987                 0.6695740            \n",
       "11033  -1.078150034                 2.5671935            \n",
       "54869  -1.110100031                 1.1950539            \n",
       "60     -0.636449993                -0.1309013            \n",
       "       BRD-A72498772__CD34__trt_cp BRD-A72796238__CD34__trt_cp\n",
       "5720    0.18455000                 -1.1793000                 \n",
       "466    -0.19575000                  1.3569000                 \n",
       "6009    0.78560001                 -0.2471000                 \n",
       "2309    0.45165002                  0.1099000                 \n",
       "387    -0.03835000                 -0.9017001                 \n",
       "3553   -0.20070001                  0.8321000                 \n",
       "427     0.44700000                  0.3969500                 \n",
       "5898   -0.01730000                 -0.1905500                 \n",
       "23365  -0.67110002                 -0.7869500                 \n",
       "6657   -0.09670001                  1.5269001                 \n",
       "5054   -0.11345001                  0.5116500                 \n",
       "3108   -0.01085000                 -1.5620000                 \n",
       "1950    0.38674998                  2.6680501                 \n",
       "351     0.31160000                  0.9131501                 \n",
       "4846    0.38900000                  3.5537500                 \n",
       "1452   -3.03379989                 -0.7344500                 \n",
       "4776   -0.03335000                  2.2428999                 \n",
       "6908   -0.39605001                  0.2097500                 \n",
       "672     0.57854998                  0.4603500                 \n",
       "5710    0.30835003                 -1.5607500                 \n",
       "2115    0.02805001                  0.9752501                 \n",
       "7015    0.56625003                  0.9501500                 \n",
       "8726    0.02245000                 -0.7093000                 \n",
       "2185   -0.24249998                 -3.3810499                 \n",
       "3315   -0.32495001                 -2.3188000                 \n",
       "5289   -0.23465000                  1.0276000                 \n",
       "868    -0.59965003                  0.4235500                 \n",
       "1677   -0.52419996                  0.9599000                 \n",
       "7043   -0.46219999                  0.2445500                 \n",
       "5613   -0.14775001                 -0.1435000                 \n",
       "⋮      ⋮                           ⋮                          \n",
       "54552  -0.372799993                 1.4985501                 \n",
       "54920  -0.076900005                -0.5360000                 \n",
       "11178  -0.897199988                 0.0240500                 \n",
       "93643   0.206200004                 0.4028500                 \n",
       "112869  0.133000001                -0.2637000                 \n",
       "51147  -0.194200009                 0.8002999                 \n",
       "196403 -0.328400016                 1.8518502                 \n",
       "389677  0.425999999                 0.2757500                 \n",
       "1296   -0.204600006                 2.2550499                 \n",
       "85352   0.086000010                 1.2165500                 \n",
       "57610  -0.926600039                 0.0807500                 \n",
       "27147  -0.410300016                 0.1346500                 \n",
       "79591   0.523100019                -0.0559500                 \n",
       "92595   0.559400022                 1.5563999                 \n",
       "51063  -0.298150003                 0.2594000                 \n",
       "55223   0.505299985                 0.4320000                 \n",
       "80022   0.208849996                -0.3577000                 \n",
       "55589   0.037900001                 0.5296500                 \n",
       "376267 -0.157900006                 1.0916001                 \n",
       "84820  -0.251900017                 1.5041499                 \n",
       "2931   -0.576700032                 0.1173000                 \n",
       "63876  -0.005400002                 0.2307501                 \n",
       "51275   0.963299990                 1.4400499                 \n",
       "158747 -0.646350026                -1.1307499                 \n",
       "283232 -0.094699994                 1.7906501                 \n",
       "25960   0.072649986                 0.1602500                 \n",
       "6376    0.684000015                -0.2364000                 \n",
       "11033  -0.160849988                 0.1246000                 \n",
       "54869  -0.178350002                 1.4240000                 \n",
       "60     -0.509249985                -0.4348000                 \n",
       "       BRD-A73513677__CD34__trt_cp BRD-A73558769__CD34__trt_cp ⋯\n",
       "5720    0.34680000                  0.10225001                 ⋯\n",
       "466     0.32670000                  0.36719999                 ⋯\n",
       "6009    1.50240004                 -0.47415000                 ⋯\n",
       "2309   -0.58609998                 -1.34329998                 ⋯\n",
       "387     1.18655002                  0.68274999                 ⋯\n",
       "3553    2.93820000                 -0.08945002                 ⋯\n",
       "427     0.57410002                 -0.11010003                 ⋯\n",
       "5898   -0.82900000                 -0.52789998                 ⋯\n",
       "23365   0.49564999                  1.38380003                 ⋯\n",
       "6657   -0.28994998                 -0.26674998                 ⋯\n",
       "5054   -0.07969996                 -0.21934998                 ⋯\n",
       "3108    0.59775001                  0.97039998                 ⋯\n",
       "1950   -0.73095000                 -0.51055002                 ⋯\n",
       "351     0.33724999                 -0.51849997                 ⋯\n",
       "4846   -0.76929998                 -0.95864999                 ⋯\n",
       "1452    0.70099998                  0.10130000                 ⋯\n",
       "4776    0.25165001                  0.55704999                 ⋯\n",
       "6908    0.72994995                  0.24660000                 ⋯\n",
       "672    -0.35640001                 -0.57574999                 ⋯\n",
       "5710   -1.05330002                  1.03775001                 ⋯\n",
       "2115   -0.80159998                 -0.07155001                 ⋯\n",
       "7015   -0.29589999                 -0.62774998                 ⋯\n",
       "8726   -0.07795000                 -0.39450002                 ⋯\n",
       "2185   -0.36440000                  0.63944995                 ⋯\n",
       "3315   -0.12619999                 -0.08780000                 ⋯\n",
       "5289   -0.56045002                 -0.05330001                 ⋯\n",
       "868    -0.48370001                 -1.28314996                 ⋯\n",
       "1677   -0.76335001                 -0.10170000                 ⋯\n",
       "7043   -0.48930001                  0.63644999                 ⋯\n",
       "5613    0.24705002                  0.45889997                 ⋯\n",
       "⋮      ⋮                           ⋮                           ⋱\n",
       "54552  -0.04715000                 -0.15339999                 ⋯\n",
       "54920  -1.17120004                  0.30594999                 ⋯\n",
       "11178  -0.16354999                  0.00515002                 ⋯\n",
       "93643   0.18150002                 -1.33759999                 ⋯\n",
       "112869 -0.80325001                 -0.37760001                 ⋯\n",
       "51147  -0.16949999                  0.07554999                 ⋯\n",
       "196403 -0.13325000                 -1.07975006                 ⋯\n",
       "389677 -0.60355002                 -0.66229999                 ⋯\n",
       "1296    0.10470000                  0.11945000                 ⋯\n",
       "85352   0.69494998                 -0.19315001                 ⋯\n",
       "57610  -0.57225001                  0.07119998                 ⋯\n",
       "27147  -0.54540002                 -0.01105000                 ⋯\n",
       "79591   0.24710000                  0.37870002                 ⋯\n",
       "92595   0.02030000                 -0.36090001                 ⋯\n",
       "51063   0.28309998                  0.09540004                 ⋯\n",
       "55223  -0.73879999                 -1.00734997                 ⋯\n",
       "80022  -0.80614996                  0.93999994                 ⋯\n",
       "55589   0.20385003                 -0.57599998                 ⋯\n",
       "376267 -0.20415001                 -0.42180002                 ⋯\n",
       "84820  -0.12639999                 -0.49724999                 ⋯\n",
       "2931   -0.68005002                  0.33640003                 ⋯\n",
       "63876  -0.44770002                 -0.46705002                 ⋯\n",
       "51275   0.39770001                  0.27579999                 ⋯\n",
       "158747  0.18900004                  1.36570001                 ⋯\n",
       "283232 -0.75310004                  0.58985001                 ⋯\n",
       "25960   0.26474997                  0.05900000                 ⋯\n",
       "6376   -0.22969997                 -1.19679999                 ⋯\n",
       "11033   1.15509999                  0.12650001                 ⋯\n",
       "54869  -0.01594999                  1.36944997                 ⋯\n",
       "60      0.53165001                  0.25479999                 ⋯\n",
       "       MW-MITF24__MCF7__trt_cp l-buthionine-sulfoximine__PC3__trt_cp\n",
       "5720   -2.1606                 -0.2913                              \n",
       "466    -1.9576                 -0.6859                              \n",
       "6009   -1.9373                 -0.7577                              \n",
       "2309    0.9808                 -0.0848                              \n",
       "387    -1.5168                  0.0997                              \n",
       "3553    3.2767                  0.0000                              \n",
       "427     0.5427                 -0.5669                              \n",
       "5898   -0.3057                  0.1609                              \n",
       "23365  -0.7719                 -0.3665                              \n",
       "6657    2.3400                  0.8720                              \n",
       "5054    0.6593                  0.2299                              \n",
       "3108    0.6745                  0.3049                              \n",
       "1950    0.8943                  0.2505                              \n",
       "351     1.2067                  0.8746                              \n",
       "4846   -1.2723                  1.0611                              \n",
       "1452   -1.9790                  0.3489                              \n",
       "4776    3.3373                  0.5311                              \n",
       "6908   -2.6201                  0.3546                              \n",
       "672    -0.0347                  0.5236                              \n",
       "5710   -0.8548                  0.0244                              \n",
       "2115    1.7185                  0.0407                              \n",
       "7015    1.2487                  0.5907                              \n",
       "8726   -1.6259                 -0.1834                              \n",
       "2185    2.5788                  1.2502                              \n",
       "3315    0.0000                 -0.5599                              \n",
       "5289    0.8281                 -0.9206                              \n",
       "868     0.1421                  0.7650                              \n",
       "1677    0.3969                  0.9042                              \n",
       "7043    0.0147                  1.1314                              \n",
       "5613    0.0717                  0.5023                              \n",
       "⋮      ⋮                       ⋮                                    \n",
       "54552   1.8504                 -0.2516                              \n",
       "54920   0.4583                  0.8514                              \n",
       "11178  -1.7519                  0.3908                              \n",
       "93643   2.1395                 -0.4617                              \n",
       "112869  2.3786                  1.1703                              \n",
       "51147   1.9107                  1.5612                              \n",
       "196403  1.4798                  0.1850                              \n",
       "389677  0.6175                 -0.6872                              \n",
       "1296    0.9755                  0.6923                              \n",
       "85352  -0.0009                  3.7638                              \n",
       "57610   1.5447                 -0.0599                              \n",
       "27147   1.3721                 -0.4534                              \n",
       "79591   2.1479                  1.1361                              \n",
       "92595   0.3339                  1.3473                              \n",
       "51063   0.9597                  1.8933                              \n",
       "55223  -0.7425                  1.5926                              \n",
       "80022   1.0909                  0.1379                              \n",
       "55589  -1.7398                  1.1566                              \n",
       "376267  0.1199                  1.2685                              \n",
       "84820   1.1424                 -0.0597                              \n",
       "2931    0.2727                  0.5013                              \n",
       "63876  -0.7579                 -0.6265                              \n",
       "51275   0.3883                  0.6793                              \n",
       "158747  2.4502                  1.9125                              \n",
       "283232  0.3257                  1.1194                              \n",
       "25960   0.8320                 -0.3680                              \n",
       "6376    1.1901                 -0.0144                              \n",
       "11033   1.2484                 -0.1491                              \n",
       "54869  -0.1743                  1.0657                              \n",
       "60     -1.4556                 -0.2475                              \n",
       "       alpha-tocopherol__PC3__trt_cp cisplatin__PC3__trt_cp\n",
       "5720   -1.2731                       -0.5659               \n",
       "466     0.5907                       -0.2468               \n",
       "6009   -1.8149                        0.0000               \n",
       "2309   -1.5376                        0.6194               \n",
       "387    -0.3862                        0.1973               \n",
       "3553   -0.1367                       -0.6745               \n",
       "427    -0.7753                       -0.8029               \n",
       "5898    0.2776                        0.0750               \n",
       "23365   0.7769                        0.3405               \n",
       "6657    1.4368                        0.5604               \n",
       "5054    0.5751                        0.2370               \n",
       "3108   -0.5842                       -0.3346               \n",
       "1950    1.1675                       -0.0811               \n",
       "351    -1.4754                        0.3245               \n",
       "4846    0.0000                        0.8742               \n",
       "1452   -0.7107                       -1.8170               \n",
       "4776    1.3320                        0.3057               \n",
       "6908   -0.8340                        0.1707               \n",
       "672    -1.3417                        0.5860               \n",
       "5710   -0.4195                        0.8007               \n",
       "2115    0.8669                       -2.4175               \n",
       "7015    0.8714                        0.6421               \n",
       "8726   -0.9279                       -5.2129               \n",
       "2185    1.2122                        0.2189               \n",
       "3315   -0.7747                        0.9959               \n",
       "5289    0.6822                       -0.9480               \n",
       "868     0.4446                        0.2584               \n",
       "1677    0.0418                        0.4508               \n",
       "7043    1.5184                        1.1396               \n",
       "5613    0.3477                       -2.3664               \n",
       "⋮      ⋮                             ⋮                     \n",
       "54552   1.3114                       -0.1993               \n",
       "54920   0.3027                        1.4400               \n",
       "11178  -1.0155                       -0.2487               \n",
       "93643   1.2257                        0.0263               \n",
       "112869  1.1386                        0.7210               \n",
       "51147   0.3518                        1.2840               \n",
       "196403  1.3844                        0.3240               \n",
       "389677  1.1080                       -0.3949               \n",
       "1296   -0.1845                        0.1797               \n",
       "85352   1.6589                        0.1591               \n",
       "57610   1.6722                        0.2858               \n",
       "27147  -0.3415                        0.3251               \n",
       "79591  -0.7604                        1.6378               \n",
       "92595   0.0010                        0.0615               \n",
       "51063   1.1444                        0.9759               \n",
       "55223   0.3204                        0.3486               \n",
       "80022   0.6538                        0.9385               \n",
       "55589  -0.5645                        1.4264               \n",
       "376267  0.9052                        0.0267               \n",
       "84820   0.7671                        0.5935               \n",
       "2931    0.8471                        0.2688               \n",
       "63876   0.8404                       -0.2692               \n",
       "51275   0.3237                       -0.4276               \n",
       "158747  0.2526                        0.5455               \n",
       "283232  0.5754                       -0.4345               \n",
       "25960   0.6608                       -0.2463               \n",
       "6376    1.5630                        0.3335               \n",
       "11033   0.0777                        0.3478               \n",
       "54869   0.7791                        1.0932               \n",
       "60     -0.6307                       -0.2042               \n",
       "       iniparib__PC3__trt_cp JMW-MITF1__PC3__trt_cp bortezomib__PC3__trt_cp\n",
       "5720    0.4571                0.0308                -0.2913                \n",
       "466     0.7582                0.4957                -1.0830                \n",
       "6009    0.3941               -1.6190                 0.1462                \n",
       "2309   -0.2978                0.5139                 2.9324                \n",
       "387    -0.4246               -0.5682                 0.6157                \n",
       "3553   -1.0342               -1.3800                -0.9713                \n",
       "427     1.6375                1.7251                 1.2290                \n",
       "5898   -2.8649                0.5809                 1.7948                \n",
       "23365  -0.6687                0.4276                -2.5250                \n",
       "6657   -1.3073               -0.8898                -0.4415                \n",
       "5054    0.4596                0.3050                -1.6550                \n",
       "3108    1.3939               -0.4618                 0.4915                \n",
       "1950   -0.4084               -0.6610                -0.0670                \n",
       "351     1.2609                0.4734                 1.3987                \n",
       "4846    0.5819                0.4788                 1.4877                \n",
       "1452    0.3777               -1.1747                 1.5557                \n",
       "4776   -0.9554               -0.9277                -1.0772                \n",
       "6908    0.7447                0.8058                -0.3623                \n",
       "672     0.7067               -0.6479                 2.8601                \n",
       "5710    0.8163               -0.6469                 2.6838                \n",
       "2115   -1.3462                0.1283                -0.6444                \n",
       "7015   -0.9362               -0.4963                -0.4187                \n",
       "8726   -0.4035                0.8041                 1.4548                \n",
       "2185   -0.3260               -0.4259                -0.4624                \n",
       "3315   -0.9554               -0.6129                 2.3237                \n",
       "5289   -0.2322               -1.1048                 0.8300                \n",
       "868     0.1067                0.5922                 1.3067                \n",
       "1677    0.3277                4.0569                -3.5420                \n",
       "7043   -0.7535               -0.1550                -0.5552                \n",
       "5613   -0.3586               -0.3032                -0.4723                \n",
       "⋮      ⋮                     ⋮                      ⋮                      \n",
       "54552  -1.4090               -0.4407                -2.0924                \n",
       "54920  -1.0779               -0.6745                 0.0638                \n",
       "11178  -0.6887               -0.6171                -0.5462                \n",
       "93643  -1.3893               -1.9883                 0.7824                \n",
       "112869 -0.1182               -0.0510                -1.0956                \n",
       "51147  -1.4728               -0.3504                 0.0130                \n",
       "196403 -0.4564                0.3414                 0.1307                \n",
       "389677 -0.7650                0.6032                -0.5789                \n",
       "1296   -0.0929                0.0885                 0.6156                \n",
       "85352  -0.6720               -1.0518                -1.5408                \n",
       "57610   1.6272               -0.8244                 0.9907                \n",
       "27147  -1.3887                0.4315                 0.1750                \n",
       "79591  -0.0226                0.0510                -0.0003                \n",
       "92595  -0.2524                0.0479                -0.3532                \n",
       "51063  -0.1300               -0.5763                -0.3481                \n",
       "55223  -1.2565               -0.0055                -0.3076                \n",
       "80022  -0.8598               -0.1190                -1.1109                \n",
       "55589   1.8400               -0.1273                 1.2060                \n",
       "376267  0.0809               -1.1636                 0.2976                \n",
       "84820  -0.5742               -1.0844                -0.5707                \n",
       "2931    0.7681               -0.5762                -0.8154                \n",
       "63876   0.8911               -0.2046                -0.8071                \n",
       "51275   0.7665                0.5685                -1.0498                \n",
       "158747  0.1402               -0.9180                -1.9362                \n",
       "283232 -3.3375                0.5196                -1.5637                \n",
       "25960  -2.4105                0.1107                -0.2676                \n",
       "6376    1.0411               -1.1291                 0.6466                \n",
       "11033  -0.7770               -0.2837                -0.0944                \n",
       "54869  -0.5247               -0.5104                -0.2863                \n",
       "60      0.7773                0.3077                 1.8114                \n",
       "       selumetinib__PC3__trt_cp glutamine__PC3__trt_cp MW-MITF24__PC3__trt_cp\n",
       "5720   -0.9489                  -1.0550                -1.9929               \n",
       "466     0.3153                   1.3292                -0.5015               \n",
       "6009   -2.1747                  -0.2952                -2.1053               \n",
       "2309   -0.9933                  -0.0140                -1.1789               \n",
       "387    -0.3696                   0.3436                -3.2787               \n",
       "3553    1.2338                  -1.3174                -0.6564               \n",
       "427     0.0243                  -0.7690                -0.6058               \n",
       "5898   -0.0093                   1.2902                 0.2903               \n",
       "23365   0.0963                   0.0482                 0.0963               \n",
       "6657    0.7747                  -0.3321                 2.5004               \n",
       "5054    0.0137                   0.4267                 0.6745               \n",
       "3108    0.0590                   0.1180                 1.7550               \n",
       "1950    1.3110                  -1.1154                 2.5754               \n",
       "351    -0.1130                  -0.8090                 0.3988               \n",
       "4846   -0.3579                  -0.6335                -0.7591               \n",
       "1452   -0.0845                  -1.1233                -1.5332               \n",
       "4776    0.3361                  -0.9042                 3.1649               \n",
       "6908   -1.9207                   0.1919                -1.5016               \n",
       "672     2.8988                  -0.1277                 0.1526               \n",
       "5710   -0.4705                  -1.5872                -1.9920               \n",
       "2115    0.9818                  -0.0399                 0.1548               \n",
       "7015    0.6203                  -0.1979                 3.4552               \n",
       "8726    1.4854                   1.7362                 1.4854               \n",
       "2185    1.4268                  -1.4473                 2.8440               \n",
       "3315   -0.7365                  -0.4083                -3.0874               \n",
       "5289    0.4654                  -0.5206                 0.6745               \n",
       "868    -0.8527                  -0.3135                 0.8328               \n",
       "1677   -0.8606                  -0.0633                 2.4948               \n",
       "7043    0.9483                   0.5121                 0.9929               \n",
       "5613   -0.3586                  -0.7751                 1.1149               \n",
       "⋮      ⋮                        ⋮                      ⋮                     \n",
       "54552   0.6877                   0.7649                -0.1186               \n",
       "54920   0.4723                   0.0850                 0.7503               \n",
       "11178  -0.1172                  -1.4105                 0.1631               \n",
       "93643   0.2161                  -0.5916                 2.0450               \n",
       "112869  0.8456                  -0.5989                 1.1402               \n",
       "51147   0.4459                  -0.4840                 0.9162               \n",
       "196403  0.2026                  -1.4586                 1.7090               \n",
       "389677  0.8575                   1.2912                -0.5854               \n",
       "1296    0.2872                  -0.6606                 0.7912               \n",
       "85352  -0.1605                   0.1139                 2.4243               \n",
       "57610   0.4710                   0.1368                 1.4276               \n",
       "27147  -0.6396                  -1.0847                 1.3937               \n",
       "79591  -0.4592                   0.8158                 1.6554               \n",
       "92595  -0.2950                   0.0858                 0.1184               \n",
       "51063  -1.0736                  -0.0896                 1.2923               \n",
       "55223  -0.5895                  -0.6759                 1.1372               \n",
       "80022   0.0832                  -0.2971                 0.8936               \n",
       "55589   0.2184                   1.3779                -0.5626               \n",
       "376267  1.9446                  -0.9014                 1.8036               \n",
       "84820   2.0601                  -0.2694                 1.1255               \n",
       "2931   -0.0992                  -0.7370                 1.7226               \n",
       "63876  -0.1506                  -1.6715                 0.9172               \n",
       "51275   1.5715                  -1.7042                -0.0870               \n",
       "158747  1.3076                  -0.5795                 0.3890               \n",
       "283232  1.1416                   0.2517                -0.1119               \n",
       "25960   0.6119                   1.1775                 0.9155               \n",
       "6376    1.4029                  -1.0273                 0.0192               \n",
       "11033   0.7815                  -0.3094                 2.2588               \n",
       "54869  -0.5035                   1.2087                 2.5072               \n",
       "60     -1.0285                   0.0535                -1.3198               "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "query(eh, c(\"signatureSearchData\", \"lincs\"))\n",
    "lincs_path <- eh[[\"EH3226\"]]\n",
    "h5ls(lincs_path)\n",
    "lincs <- SummarizedExperiment(HDF5Array(lincs_path, name=\"assay\"))\n",
    "lincs <- as.matrix(lincs@assays@data[[1]])\n",
    "rownames(lincs) <- HDF5Array(lincs_path, name=\"rownames\")[,1]\n",
    "colnames(lincs) <- HDF5Array(lincs_path, name=\"colnames\")[,1] #12328 x 45956\n",
    "lincs"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 31,
   "id": "246033ee-57cb-4f94-87cc-5c4e940eb77d",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:12.753494Z",
     "iopub.status.busy": "2021-09-23T06:22:12.750009Z",
     "iopub.status.idle": "2021-09-23T06:22:12.908881Z",
     "shell.execute_reply": "2021-09-23T06:22:12.907709Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "'select()' returned 1:1 mapping between keys and columns\n",
      "\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 4 × 2</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>SYMBOL</th><th scope=col>ENTREZID</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>1</th><td>VENTX</td><td>27287</td></tr>\n",
       "\t<tr><th scope=row>2</th><td>OTP  </td><td>23440</td></tr>\n",
       "\t<tr><th scope=row>3</th><td>ISL1 </td><td>3670 </td></tr>\n",
       "\t<tr><th scope=row>4</th><td>HOXC5</td><td>3222 </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 4 × 2\n",
       "\\begin{tabular}{r|ll}\n",
       "  & SYMBOL & ENTREZID\\\\\n",
       "  & <chr> & <chr>\\\\\n",
       "\\hline\n",
       "\t1 & VENTX & 27287\\\\\n",
       "\t2 & OTP   & 23440\\\\\n",
       "\t3 & ISL1  & 3670 \\\\\n",
       "\t4 & HOXC5 & 3222 \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 4 × 2\n",
       "\n",
       "| <!--/--> | SYMBOL &lt;chr&gt; | ENTREZID &lt;chr&gt; |\n",
       "|---|---|---|\n",
       "| 1 | VENTX | 27287 |\n",
       "| 2 | OTP   | 23440 |\n",
       "| 3 | ISL1  | 3670  |\n",
       "| 4 | HOXC5 | 3222  |\n",
       "\n"
      ],
      "text/plain": [
       "  SYMBOL ENTREZID\n",
       "1 VENTX  27287   \n",
       "2 OTP    23440   \n",
       "3 ISL1   3670    \n",
       "4 HOXC5  3222    "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "#### load tumor-specific TFs\n",
    "tumor.specific.TFs <- readRDS(\"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/scATAC/5.Motif/Analysis/tumor.specific.TFs.rds\")\n",
    "idx <- which(tumor.specific.TFs$Name %in% c(\"HOXC5\", \"VENTX\", \"ISL1\", \"OTP\"))\n",
    "tumor.specific.TFs <- tumor.specific.TFs[idx,]\n",
    "#convert to entrez id\n",
    "source(file = \"/home/longzhilin/Analysis_Code/IDConvert.R\")\n",
    "gene.info <- IDConvert(tumor.specific.TFs$Name, method = \"clusterProfiler\", fromType = \"SYMBOL\", toType = \"ENTREZID\")\n",
    "gene.info"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "e9468716-4dad-4a8d-8df4-d1169132a807",
   "metadata": {
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "id": "62aad8e3-20fb-4ae0-9b99-b33a18cac8f4",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:17.113899Z",
     "iopub.status.busy": "2021-09-23T06:22:17.109459Z",
     "iopub.status.idle": "2021-09-23T06:22:17.249510Z",
     "shell.execute_reply": "2021-09-23T06:22:17.248321Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A matrix: 3 × 45956 of type dbl</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>BRD-A03772856__CD34__trt_cp</th><th scope=col>trichostatin-a__CD34__trt_cp</th><th scope=col>geldanamycin__CD34__trt_cp</th><th scope=col>KUC107191N__CD34__trt_cp</th><th scope=col>BRD-A35207501__CD34__trt_cp</th><th scope=col>iloprost__CD34__trt_cp</th><th scope=col>BRD-A72498772__CD34__trt_cp</th><th scope=col>BRD-A72796238__CD34__trt_cp</th><th scope=col>BRD-A73513677__CD34__trt_cp</th><th scope=col>BRD-A73558769__CD34__trt_cp</th><th scope=col>⋯</th><th scope=col>MW-MITF24__MCF7__trt_cp</th><th scope=col>l-buthionine-sulfoximine__PC3__trt_cp</th><th scope=col>alpha-tocopherol__PC3__trt_cp</th><th scope=col>cisplatin__PC3__trt_cp</th><th scope=col>iniparib__PC3__trt_cp</th><th scope=col>JMW-MITF1__PC3__trt_cp</th><th scope=col>bortezomib__PC3__trt_cp</th><th scope=col>selumetinib__PC3__trt_cp</th><th scope=col>glutamine__PC3__trt_cp</th><th scope=col>MW-MITF24__PC3__trt_cp</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>VENTX</th><td>-0.86745</td><td>2.6854</td><td>2.93140</td><td>0.31655</td><td>0.26720</td><td>1.3062376</td><td>-0.37835</td><td>0.5864</td><td>-0.19235</td><td>-0.36255</td><td>⋯</td><td>1.6858</td><td>0.4772</td><td> 0.6672</td><td>0.4269</td><td>-0.6599</td><td>-0.7321</td><td>-0.5295</td><td>0.8246</td><td>-0.9867</td><td> 1.9501</td></tr>\n",
       "\t<tr><th scope=row>ISL1</th><td>-0.18340</td><td>0.0290</td><td>2.10840</td><td>0.86345</td><td>0.12125</td><td>0.4669212</td><td> 0.60240</td><td>1.9325</td><td> 0.64980</td><td>-0.45065</td><td>⋯</td><td>2.4253</td><td>2.1372</td><td>-2.3109</td><td>0.4266</td><td>-0.1666</td><td> 0.6976</td><td>-3.8550</td><td>1.1637</td><td> 0.0608</td><td>-0.5077</td></tr>\n",
       "\t<tr><th scope=row>HOXC5</th><td>-0.59025</td><td>3.2782</td><td>2.69445</td><td>1.32265</td><td>0.61415</td><td>2.0156755</td><td>-0.21200</td><td>1.0597</td><td>-0.46980</td><td> 0.28235</td><td>⋯</td><td>1.1215</td><td>0.7762</td><td> 0.2086</td><td>0.1258</td><td>-0.5124</td><td> 0.6798</td><td>-1.9251</td><td>0.6460</td><td>-1.3305</td><td> 0.4147</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A matrix: 3 × 45956 of type dbl\n",
       "\\begin{tabular}{r|lllllllllllllllllllll}\n",
       "  & BRD-A03772856\\_\\_CD34\\_\\_trt\\_cp & trichostatin-a\\_\\_CD34\\_\\_trt\\_cp & geldanamycin\\_\\_CD34\\_\\_trt\\_cp & KUC107191N\\_\\_CD34\\_\\_trt\\_cp & BRD-A35207501\\_\\_CD34\\_\\_trt\\_cp & iloprost\\_\\_CD34\\_\\_trt\\_cp & BRD-A72498772\\_\\_CD34\\_\\_trt\\_cp & BRD-A72796238\\_\\_CD34\\_\\_trt\\_cp & BRD-A73513677\\_\\_CD34\\_\\_trt\\_cp & BRD-A73558769\\_\\_CD34\\_\\_trt\\_cp & ⋯ & MW-MITF24\\_\\_MCF7\\_\\_trt\\_cp & l-buthionine-sulfoximine\\_\\_PC3\\_\\_trt\\_cp & alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & cisplatin\\_\\_PC3\\_\\_trt\\_cp & iniparib\\_\\_PC3\\_\\_trt\\_cp & JMW-MITF1\\_\\_PC3\\_\\_trt\\_cp & bortezomib\\_\\_PC3\\_\\_trt\\_cp & selumetinib\\_\\_PC3\\_\\_trt\\_cp & glutamine\\_\\_PC3\\_\\_trt\\_cp & MW-MITF24\\_\\_PC3\\_\\_trt\\_cp\\\\\n",
       "\\hline\n",
       "\tVENTX & -0.86745 & 2.6854 & 2.93140 & 0.31655 & 0.26720 & 1.3062376 & -0.37835 & 0.5864 & -0.19235 & -0.36255 & ⋯ & 1.6858 & 0.4772 &  0.6672 & 0.4269 & -0.6599 & -0.7321 & -0.5295 & 0.8246 & -0.9867 &  1.9501\\\\\n",
       "\tISL1 & -0.18340 & 0.0290 & 2.10840 & 0.86345 & 0.12125 & 0.4669212 &  0.60240 & 1.9325 &  0.64980 & -0.45065 & ⋯ & 2.4253 & 2.1372 & -2.3109 & 0.4266 & -0.1666 &  0.6976 & -3.8550 & 1.1637 &  0.0608 & -0.5077\\\\\n",
       "\tHOXC5 & -0.59025 & 3.2782 & 2.69445 & 1.32265 & 0.61415 & 2.0156755 & -0.21200 & 1.0597 & -0.46980 &  0.28235 & ⋯ & 1.1215 & 0.7762 &  0.2086 & 0.1258 & -0.5124 &  0.6798 & -1.9251 & 0.6460 & -1.3305 &  0.4147\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A matrix: 3 × 45956 of type dbl\n",
       "\n",
       "| <!--/--> | BRD-A03772856__CD34__trt_cp | trichostatin-a__CD34__trt_cp | geldanamycin__CD34__trt_cp | KUC107191N__CD34__trt_cp | BRD-A35207501__CD34__trt_cp | iloprost__CD34__trt_cp | BRD-A72498772__CD34__trt_cp | BRD-A72796238__CD34__trt_cp | BRD-A73513677__CD34__trt_cp | BRD-A73558769__CD34__trt_cp | ⋯ | MW-MITF24__MCF7__trt_cp | l-buthionine-sulfoximine__PC3__trt_cp | alpha-tocopherol__PC3__trt_cp | cisplatin__PC3__trt_cp | iniparib__PC3__trt_cp | JMW-MITF1__PC3__trt_cp | bortezomib__PC3__trt_cp | selumetinib__PC3__trt_cp | glutamine__PC3__trt_cp | MW-MITF24__PC3__trt_cp |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| VENTX | -0.86745 | 2.6854 | 2.93140 | 0.31655 | 0.26720 | 1.3062376 | -0.37835 | 0.5864 | -0.19235 | -0.36255 | ⋯ | 1.6858 | 0.4772 |  0.6672 | 0.4269 | -0.6599 | -0.7321 | -0.5295 | 0.8246 | -0.9867 |  1.9501 |\n",
       "| ISL1 | -0.18340 | 0.0290 | 2.10840 | 0.86345 | 0.12125 | 0.4669212 |  0.60240 | 1.9325 |  0.64980 | -0.45065 | ⋯ | 2.4253 | 2.1372 | -2.3109 | 0.4266 | -0.1666 |  0.6976 | -3.8550 | 1.1637 |  0.0608 | -0.5077 |\n",
       "| HOXC5 | -0.59025 | 3.2782 | 2.69445 | 1.32265 | 0.61415 | 2.0156755 | -0.21200 | 1.0597 | -0.46980 |  0.28235 | ⋯ | 1.1215 | 0.7762 |  0.2086 | 0.1258 | -0.5124 |  0.6798 | -1.9251 | 0.6460 | -1.3305 |  0.4147 |\n",
       "\n"
      ],
      "text/plain": [
       "      BRD-A03772856__CD34__trt_cp trichostatin-a__CD34__trt_cp\n",
       "VENTX -0.86745                    2.6854                      \n",
       "ISL1  -0.18340                    0.0290                      \n",
       "HOXC5 -0.59025                    3.2782                      \n",
       "      geldanamycin__CD34__trt_cp KUC107191N__CD34__trt_cp\n",
       "VENTX 2.93140                    0.31655                 \n",
       "ISL1  2.10840                    0.86345                 \n",
       "HOXC5 2.69445                    1.32265                 \n",
       "      BRD-A35207501__CD34__trt_cp iloprost__CD34__trt_cp\n",
       "VENTX 0.26720                     1.3062376             \n",
       "ISL1  0.12125                     0.4669212             \n",
       "HOXC5 0.61415                     2.0156755             \n",
       "      BRD-A72498772__CD34__trt_cp BRD-A72796238__CD34__trt_cp\n",
       "VENTX -0.37835                    0.5864                     \n",
       "ISL1   0.60240                    1.9325                     \n",
       "HOXC5 -0.21200                    1.0597                     \n",
       "      BRD-A73513677__CD34__trt_cp BRD-A73558769__CD34__trt_cp ⋯\n",
       "VENTX -0.19235                    -0.36255                    ⋯\n",
       "ISL1   0.64980                    -0.45065                    ⋯\n",
       "HOXC5 -0.46980                     0.28235                    ⋯\n",
       "      MW-MITF24__MCF7__trt_cp l-buthionine-sulfoximine__PC3__trt_cp\n",
       "VENTX 1.6858                  0.4772                               \n",
       "ISL1  2.4253                  2.1372                               \n",
       "HOXC5 1.1215                  0.7762                               \n",
       "      alpha-tocopherol__PC3__trt_cp cisplatin__PC3__trt_cp\n",
       "VENTX  0.6672                       0.4269                \n",
       "ISL1  -2.3109                       0.4266                \n",
       "HOXC5  0.2086                       0.1258                \n",
       "      iniparib__PC3__trt_cp JMW-MITF1__PC3__trt_cp bortezomib__PC3__trt_cp\n",
       "VENTX -0.6599               -0.7321                -0.5295                \n",
       "ISL1  -0.1666                0.6976                -3.8550                \n",
       "HOXC5 -0.5124                0.6798                -1.9251                \n",
       "      selumetinib__PC3__trt_cp glutamine__PC3__trt_cp MW-MITF24__PC3__trt_cp\n",
       "VENTX 0.8246                   -0.9867                 1.9501               \n",
       "ISL1  1.1637                    0.0608                -0.5077               \n",
       "HOXC5 0.6460                   -1.3305                 0.4147               "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/html": [
       "<style>\n",
       ".list-inline {list-style: none; margin:0; padding: 0}\n",
       ".list-inline>li {display: inline-block}\n",
       ".list-inline>li:not(:last-child)::after {content: \"\\00b7\"; padding: 0 .5ex}\n",
       "</style>\n",
       "<ol class=list-inline><li>3</li><li>45956</li></ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item 3\n",
       "\\item 45956\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. 3\n",
       "2. 45956\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "[1]     3 45956"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "index <- match(gene.info$ENTREZID, rownames(lincs))\n",
    "lincs.TF.matrix <- lincs[na.omit(index),]\n",
    "rownames(lincs.TF.matrix) <- gene.info$SYMBOL[which(!is.na(index))]\n",
    "lincs.TF.matrix\n",
    "dim(lincs.TF.matrix)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "id": "d4a31f92-a011-4a97-be3b-347fc8c2f761",
   "metadata": {
    "collapsed": true,
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:27.432913Z",
     "iopub.status.busy": "2021-09-23T06:22:27.429496Z",
     "iopub.status.idle": "2021-09-23T06:22:27.599993Z",
     "shell.execute_reply": "2021-09-23T06:22:27.598811Z"
    },
    "jupyter": {
     "outputs_hidden": true
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<dl>\n",
       "\t<dt>$VENTX</dt>\n",
       "\t\t<dd><table class=\"dataframe\">\n",
       "<caption>A data.frame: 80 × 2</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>drug</th><th scope=col>zscore</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>butoconazole__HCC515__trt_cp</th><td>butoconazole__HCC515__trt_cp</td><td>-2.043097</td></tr>\n",
       "\t<tr><th scope=row>amcinonide__VCAP__trt_cp</th><td>amcinonide__VCAP__trt_cp    </td><td>-2.013700</td></tr>\n",
       "\t<tr><th scope=row>verteporfin__VCAP__trt_cp</th><td>verteporfin__VCAP__trt_cp   </td><td>-2.372383</td></tr>\n",
       "\t<tr><th scope=row>napelline__HT29__trt_cp</th><td>napelline__HT29__trt_cp     </td><td>-2.024536</td></tr>\n",
       "\t<tr><th scope=row>clioquinol__HT29__trt_cp</th><td>clioquinol__HT29__trt_cp    </td><td>-2.086267</td></tr>\n",
       "\t<tr><th scope=row>NS-3694__VCAP__trt_cp</th><td>NS-3694__VCAP__trt_cp       </td><td>-2.178900</td></tr>\n",
       "\t<tr><th scope=row>AS-605240__VCAP__trt_cp</th><td>AS-605240__VCAP__trt_cp     </td><td>-2.451528</td></tr>\n",
       "\t<tr><th scope=row>SJ-172550__VCAP__trt_cp</th><td>SJ-172550__VCAP__trt_cp     </td><td>-2.893954</td></tr>\n",
       "\t<tr><th scope=row>JAS07-005__VCAP__trt_cp</th><td>JAS07-005__VCAP__trt_cp     </td><td>-2.086582</td></tr>\n",
       "\t<tr><th scope=row>BRD-A38425832__MCF7__trt_cp</th><td>BRD-A38425832__MCF7__trt_cp </td><td>-2.438600</td></tr>\n",
       "\t<tr><th scope=row>BRD-K32827536__PC3__trt_cp</th><td>BRD-K32827536__PC3__trt_cp  </td><td>-2.027371</td></tr>\n",
       "\t<tr><th scope=row>BRD-K48844671__PC3__trt_cp</th><td>BRD-K48844671__PC3__trt_cp  </td><td>-2.115793</td></tr>\n",
       "\t<tr><th scope=row>BRD-K23165181__VCAP__trt_cp</th><td>BRD-K23165181__VCAP__trt_cp </td><td>-2.151439</td></tr>\n",
       "\t<tr><th scope=row>BRD-K58247702__VCAP__trt_cp</th><td>BRD-K58247702__VCAP__trt_cp </td><td>-2.014121</td></tr>\n",
       "\t<tr><th scope=row>BRD-K70917163__VCAP__trt_cp</th><td>BRD-K70917163__VCAP__trt_cp </td><td>-2.195663</td></tr>\n",
       "\t<tr><th scope=row>KU-C104140__A549__trt_cp</th><td>KU-C104140__A549__trt_cp    </td><td>-2.076100</td></tr>\n",
       "\t<tr><th scope=row>BRD-A11095214__MCF7__trt_cp</th><td>BRD-A11095214__MCF7__trt_cp </td><td>-2.200500</td></tr>\n",
       "\t<tr><th scope=row>BRD-K33182644__MCF7__trt_cp</th><td>BRD-K33182644__MCF7__trt_cp </td><td>-2.137250</td></tr>\n",
       "\t<tr><th scope=row>BRD-K98991361__A549__trt_cp</th><td>BRD-K98991361__A549__trt_cp </td><td>-2.161300</td></tr>\n",
       "\t<tr><th scope=row>oxcarbazepine__MCF7__trt_cp</th><td>oxcarbazepine__MCF7__trt_cp </td><td>-2.080350</td></tr>\n",
       "\t<tr><th scope=row>lansoprazole__VCAP__trt_cp</th><td>lansoprazole__VCAP__trt_cp  </td><td>-2.672177</td></tr>\n",
       "\t<tr><th scope=row>kitasamycin__VCAP__trt_cp</th><td>kitasamycin__VCAP__trt_cp   </td><td>-2.771939</td></tr>\n",
       "\t<tr><th scope=row>BRD-A16581344__A549__trt_cp</th><td>BRD-A16581344__A549__trt_cp </td><td>-2.207200</td></tr>\n",
       "\t<tr><th scope=row>BRD-K88556033__A549__trt_cp</th><td>BRD-K88556033__A549__trt_cp </td><td>-2.038800</td></tr>\n",
       "\t<tr><th scope=row>RAN-27__NEU__trt_cp</th><td>RAN-27__NEU__trt_cp         </td><td>-2.076294</td></tr>\n",
       "\t<tr><th scope=row>BRD-K44893543__NEU__trt_cp</th><td>BRD-K44893543__NEU__trt_cp  </td><td>-2.608974</td></tr>\n",
       "\t<tr><th scope=row>BRD-K58279162__NEU__trt_cp</th><td>BRD-K58279162__NEU__trt_cp  </td><td>-2.688838</td></tr>\n",
       "\t<tr><th scope=row>BRD-K14316227__NPC__trt_cp</th><td>BRD-K14316227__NPC__trt_cp  </td><td>-2.204158</td></tr>\n",
       "\t<tr><th scope=row>treprostinil__PHH__trt_cp</th><td>treprostinil__PHH__trt_cp   </td><td>-2.756694</td></tr>\n",
       "\t<tr><th scope=row>BRD-K82971429__PHH__trt_cp</th><td>BRD-K82971429__PHH__trt_cp  </td><td>-2.028831</td></tr>\n",
       "\t<tr><th scope=row>⋮</th><td>⋮</td><td>⋮</td></tr>\n",
       "\t<tr><th scope=row>NSC-663284__PHH__trt_cp</th><td>NSC-663284__PHH__trt_cp        </td><td>-2.211250</td></tr>\n",
       "\t<tr><th scope=row>zoxazolamine__PHH__trt_cp</th><td>zoxazolamine__PHH__trt_cp      </td><td>-2.148100</td></tr>\n",
       "\t<tr><th scope=row>nateglinide__PHH__trt_cp</th><td>nateglinide__PHH__trt_cp       </td><td>-2.026000</td></tr>\n",
       "\t<tr><th scope=row>LFM-A13__NEU__trt_cp</th><td>LFM-A13__NEU__trt_cp           </td><td>-2.864500</td></tr>\n",
       "\t<tr><th scope=row>BML-257__NEU__trt_cp</th><td>BML-257__NEU__trt_cp           </td><td>-3.350300</td></tr>\n",
       "\t<tr><th scope=row>lamotrigine__NEU__trt_cp</th><td>lamotrigine__NEU__trt_cp       </td><td>-2.059334</td></tr>\n",
       "\t<tr><th scope=row>IC-261__PHH__trt_cp</th><td>IC-261__PHH__trt_cp            </td><td>-2.089171</td></tr>\n",
       "\t<tr><th scope=row>L-701252__PHH__trt_cp</th><td>L-701252__PHH__trt_cp          </td><td>-3.265500</td></tr>\n",
       "\t<tr><th scope=row>mometasone__PHH__trt_cp</th><td>mometasone__PHH__trt_cp        </td><td>-2.173689</td></tr>\n",
       "\t<tr><th scope=row>scoulerine__PHH__trt_cp</th><td>scoulerine__PHH__trt_cp        </td><td>-2.078122</td></tr>\n",
       "\t<tr><th scope=row>dihydroergotamine__PHH__trt_cp</th><td>dihydroergotamine__PHH__trt_cp </td><td>-2.580976</td></tr>\n",
       "\t<tr><th scope=row>dipyridamole__PHH__trt_cp</th><td>dipyridamole__PHH__trt_cp      </td><td>-2.045686</td></tr>\n",
       "\t<tr><th scope=row>tyrphostin-AG-825__MCF7__trt_cp</th><td>tyrphostin-AG-825__MCF7__trt_cp</td><td>-2.394913</td></tr>\n",
       "\t<tr><th scope=row>rosmarinic-acid__NPC__trt_cp</th><td>rosmarinic-acid__NPC__trt_cp   </td><td>-2.170692</td></tr>\n",
       "\t<tr><th scope=row>amthamine__PHH__trt_cp</th><td>amthamine__PHH__trt_cp         </td><td>-2.258550</td></tr>\n",
       "\t<tr><th scope=row>NAN-190__PHH__trt_cp</th><td>NAN-190__PHH__trt_cp           </td><td>-4.584300</td></tr>\n",
       "\t<tr><th scope=row>BRD-K24053449__MCF7__trt_cp</th><td>BRD-K24053449__MCF7__trt_cp    </td><td>-2.124968</td></tr>\n",
       "\t<tr><th scope=row>BRD-K88278225__PC3__trt_cp</th><td>BRD-K88278225__PC3__trt_cp     </td><td>-5.143122</td></tr>\n",
       "\t<tr><th scope=row>BRD-K03358980__VCAP__trt_cp</th><td>BRD-K03358980__VCAP__trt_cp    </td><td>-2.230576</td></tr>\n",
       "\t<tr><th scope=row>BRD-K06592610__VCAP__trt_cp</th><td>BRD-K06592610__VCAP__trt_cp    </td><td>-2.063635</td></tr>\n",
       "\t<tr><th scope=row>RDR-01440SC__VCAP__trt_cp</th><td>RDR-01440SC__VCAP__trt_cp      </td><td>-2.042054</td></tr>\n",
       "\t<tr><th scope=row>BRD-K76691125__VCAP__trt_cp</th><td>BRD-K76691125__VCAP__trt_cp    </td><td>-2.113669</td></tr>\n",
       "\t<tr><th scope=row>tubacin__VCAP__trt_cp</th><td>tubacin__VCAP__trt_cp          </td><td>-3.499640</td></tr>\n",
       "\t<tr><th scope=row>BRD-K47512679__NPC__trt_cp</th><td>BRD-K47512679__NPC__trt_cp     </td><td>-2.032956</td></tr>\n",
       "\t<tr><th scope=row>BRD-K05353139__HT29__trt_cp</th><td>BRD-K05353139__HT29__trt_cp    </td><td>-2.013206</td></tr>\n",
       "\t<tr><th scope=row>BRD-K48598367__NEU__trt_cp</th><td>BRD-K48598367__NEU__trt_cp     </td><td>-2.556500</td></tr>\n",
       "\t<tr><th scope=row>SA-419083__NPC__trt_cp</th><td>SA-419083__NPC__trt_cp         </td><td>-2.028479</td></tr>\n",
       "\t<tr><th scope=row>BRD-K28772322__VCAP__trt_cp</th><td>BRD-K28772322__VCAP__trt_cp    </td><td>-2.263741</td></tr>\n",
       "\t<tr><th scope=row>nocodazole__FIBRNPC__trt_cp</th><td>nocodazole__FIBRNPC__trt_cp    </td><td>-2.172350</td></tr>\n",
       "\t<tr><th scope=row>AVA__HA1E__trt_cp</th><td>AVA__HA1E__trt_cp              </td><td>-2.028199</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "</dd>\n",
       "\t<dt>$ISL1</dt>\n",
       "\t\t<dd><table class=\"dataframe\">\n",
       "<caption>A data.frame: 197 × 2</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>drug</th><th scope=col>zscore</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>BRD-K26684619__CD34__trt_cp</th><td>BRD-K26684619__CD34__trt_cp         </td><td>-2.040950</td></tr>\n",
       "\t<tr><th scope=row>BRD-A51929314__HA1E__trt_cp</th><td>BRD-A51929314__HA1E__trt_cp         </td><td>-2.227154</td></tr>\n",
       "\t<tr><th scope=row>MRS-1845__HCC515__trt_cp</th><td>MRS-1845__HCC515__trt_cp            </td><td>-2.417191</td></tr>\n",
       "\t<tr><th scope=row>melperone__HCC515__trt_cp</th><td>melperone__HCC515__trt_cp           </td><td>-2.385237</td></tr>\n",
       "\t<tr><th scope=row>FCCP__HCC515__trt_cp</th><td>FCCP__HCC515__trt_cp                </td><td>-2.176191</td></tr>\n",
       "\t<tr><th scope=row>BCL2-inhibitor__VCAP__trt_cp</th><td>BCL2-inhibitor__VCAP__trt_cp        </td><td>-2.520154</td></tr>\n",
       "\t<tr><th scope=row>ubenimex__VCAP__trt_cp</th><td>ubenimex__VCAP__trt_cp              </td><td>-2.167702</td></tr>\n",
       "\t<tr><th scope=row>epitestosterone__VCAP__trt_cp</th><td>epitestosterone__VCAP__trt_cp       </td><td>-2.142600</td></tr>\n",
       "\t<tr><th scope=row>procainamide__VCAP__trt_cp</th><td>procainamide__VCAP__trt_cp          </td><td>-2.136900</td></tr>\n",
       "\t<tr><th scope=row>anagrelide__HA1E__trt_cp</th><td>anagrelide__HA1E__trt_cp            </td><td>-2.888882</td></tr>\n",
       "\t<tr><th scope=row>bithionol__HCC515__trt_cp</th><td>bithionol__HCC515__trt_cp           </td><td>-2.335168</td></tr>\n",
       "\t<tr><th scope=row>GW-1929__VCAP__trt_cp</th><td>GW-1929__VCAP__trt_cp               </td><td>-3.890623</td></tr>\n",
       "\t<tr><th scope=row>CMPD-1__A375__trt_cp</th><td>CMPD-1__A375__trt_cp                </td><td>-2.118605</td></tr>\n",
       "\t<tr><th scope=row>ST-638__HA1E__trt_cp</th><td>ST-638__HA1E__trt_cp                </td><td>-2.139165</td></tr>\n",
       "\t<tr><th scope=row>fluocinolone-acetonide__HT29__trt_cp</th><td>fluocinolone-acetonide__HT29__trt_cp</td><td>-2.311850</td></tr>\n",
       "\t<tr><th scope=row>mitoxantrone__HT29__trt_cp</th><td>mitoxantrone__HT29__trt_cp          </td><td>-2.173384</td></tr>\n",
       "\t<tr><th scope=row>L-168049__VCAP__trt_cp</th><td>L-168049__VCAP__trt_cp              </td><td>-2.498789</td></tr>\n",
       "\t<tr><th scope=row>BX-795__HT29__trt_cp</th><td>BX-795__HT29__trt_cp                </td><td>-2.146887</td></tr>\n",
       "\t<tr><th scope=row>cucurbitacin-i__MCF7__trt_cp</th><td>cucurbitacin-i__MCF7__trt_cp        </td><td>-2.131572</td></tr>\n",
       "\t<tr><th scope=row>CT-200783__VCAP__trt_cp</th><td>CT-200783__VCAP__trt_cp             </td><td>-2.346538</td></tr>\n",
       "\t<tr><th scope=row>BRD-K60870698__A375__trt_cp</th><td>BRD-K60870698__A375__trt_cp         </td><td>-2.611861</td></tr>\n",
       "\t<tr><th scope=row>BRD-K84203638__A375__trt_cp</th><td>BRD-K84203638__A375__trt_cp         </td><td>-2.241982</td></tr>\n",
       "\t<tr><th scope=row>BRD-K05153001__A549__trt_cp</th><td>BRD-K05153001__A549__trt_cp         </td><td>-2.140815</td></tr>\n",
       "\t<tr><th scope=row>BRD-K85275009__A549__trt_cp</th><td>BRD-K85275009__A549__trt_cp         </td><td>-4.711900</td></tr>\n",
       "\t<tr><th scope=row>BRD-K05402890__HA1E__trt_cp</th><td>BRD-K05402890__HA1E__trt_cp         </td><td>-2.309873</td></tr>\n",
       "\t<tr><th scope=row>BRD-A58924247__HT29__trt_cp</th><td>BRD-A58924247__HT29__trt_cp         </td><td>-2.229404</td></tr>\n",
       "\t<tr><th scope=row>BRD-K91691979__PC3__trt_cp</th><td>BRD-K91691979__PC3__trt_cp          </td><td>-2.309459</td></tr>\n",
       "\t<tr><th scope=row>BRD-K19735876__A375__trt_cp</th><td>BRD-K19735876__A375__trt_cp         </td><td>-2.083350</td></tr>\n",
       "\t<tr><th scope=row>BRD-A21406558__MCF7__trt_cp</th><td>BRD-A21406558__MCF7__trt_cp         </td><td>-2.156250</td></tr>\n",
       "\t<tr><th scope=row>BRD-K07259155__MCF7__trt_cp</th><td>BRD-K07259155__MCF7__trt_cp         </td><td>-2.299050</td></tr>\n",
       "\t<tr><th scope=row>⋮</th><td>⋮</td><td>⋮</td></tr>\n",
       "\t<tr><th scope=row>SR-12813__NEU__trt_cp</th><td>SR-12813__NEU__trt_cp               </td><td>-2.061450</td></tr>\n",
       "\t<tr><th scope=row>LBH-589__NEU__trt_cp</th><td>LBH-589__NEU__trt_cp                </td><td>-2.051542</td></tr>\n",
       "\t<tr><th scope=row>BG-1003__NPC__trt_cp</th><td>BG-1003__NPC__trt_cp                </td><td>-2.050464</td></tr>\n",
       "\t<tr><th scope=row>LBH-589__NPC__trt_cp</th><td>LBH-589__NPC__trt_cp                </td><td>-2.351810</td></tr>\n",
       "\t<tr><th scope=row>BG-1008__NEU__trt_cp</th><td>BG-1008__NEU__trt_cp                </td><td>-2.506527</td></tr>\n",
       "\t<tr><th scope=row>temozolomide__NEU__trt_cp</th><td>temozolomide__NEU__trt_cp           </td><td>-2.358148</td></tr>\n",
       "\t<tr><th scope=row>BG-1005__NEU__trt_cp</th><td>BG-1005__NEU__trt_cp                </td><td>-2.408175</td></tr>\n",
       "\t<tr><th scope=row>BG-1025__NEU__trt_cp</th><td>BG-1025__NEU__trt_cp                </td><td>-2.330200</td></tr>\n",
       "\t<tr><th scope=row>C2-dihydroceramide__NEU__trt_cp</th><td>C2-dihydroceramide__NEU__trt_cp     </td><td>-2.060200</td></tr>\n",
       "\t<tr><th scope=row>BG-1030__NEU__trt_cp</th><td>BG-1030__NEU__trt_cp                </td><td>-2.047566</td></tr>\n",
       "\t<tr><th scope=row>oxamflatin__NPC__trt_cp</th><td>oxamflatin__NPC__trt_cp             </td><td>-2.670142</td></tr>\n",
       "\t<tr><th scope=row>BG-1029__NPC__trt_cp</th><td>BG-1029__NPC__trt_cp                </td><td>-2.168213</td></tr>\n",
       "\t<tr><th scope=row>BG-1006__NPC__trt_cp</th><td>BG-1006__NPC__trt_cp                </td><td>-2.664152</td></tr>\n",
       "\t<tr><th scope=row>BML-284__NPC__trt_cp</th><td>BML-284__NPC__trt_cp                </td><td>-4.036828</td></tr>\n",
       "\t<tr><th scope=row>M-344__NPC__trt_cp</th><td>M-344__NPC__trt_cp                  </td><td>-2.041860</td></tr>\n",
       "\t<tr><th scope=row>BG-1025__NPC__trt_cp</th><td>BG-1025__NPC__trt_cp                </td><td>-2.107575</td></tr>\n",
       "\t<tr><th scope=row>BG-1026__NPC__trt_cp</th><td>BG-1026__NPC__trt_cp                </td><td>-2.440128</td></tr>\n",
       "\t<tr><th scope=row>NCH-51__NPC__trt_cp</th><td>NCH-51__NPC__trt_cp                 </td><td>-2.122013</td></tr>\n",
       "\t<tr><th scope=row>BG-1007__NPC__trt_cp</th><td>BG-1007__NPC__trt_cp                </td><td>-2.229874</td></tr>\n",
       "\t<tr><th scope=row>BG-1028__NPC__trt_cp</th><td>BG-1028__NPC__trt_cp                </td><td>-2.391268</td></tr>\n",
       "\t<tr><th scope=row>BG-1027__NPC__trt_cp</th><td>BG-1027__NPC__trt_cp                </td><td>-2.334610</td></tr>\n",
       "\t<tr><th scope=row>tert-butylhydroquinone__MCF7__trt_cp</th><td>tert-butylhydroquinone__MCF7__trt_cp</td><td>-3.080953</td></tr>\n",
       "\t<tr><th scope=row>panobinostat__A375__trt_cp</th><td>panobinostat__A375__trt_cp          </td><td>-2.063759</td></tr>\n",
       "\t<tr><th scope=row>staurosporine__A375__trt_cp</th><td>staurosporine__A375__trt_cp         </td><td>-3.507200</td></tr>\n",
       "\t<tr><th scope=row>apicidin__A375__trt_cp</th><td>apicidin__A375__trt_cp              </td><td>-2.681550</td></tr>\n",
       "\t<tr><th scope=row>BRD-K57064803__MCF7__trt_cp</th><td>BRD-K57064803__MCF7__trt_cp         </td><td>-2.356925</td></tr>\n",
       "\t<tr><th scope=row>alpha-tocopherol__MCF7__trt_cp</th><td>alpha-tocopherol__MCF7__trt_cp      </td><td>-2.502400</td></tr>\n",
       "\t<tr><th scope=row>JMW-MITF1__MCF7__trt_cp</th><td>JMW-MITF1__MCF7__trt_cp             </td><td>-2.199600</td></tr>\n",
       "\t<tr><th scope=row>alpha-tocopherol__PC3__trt_cp</th><td>alpha-tocopherol__PC3__trt_cp       </td><td>-2.310900</td></tr>\n",
       "\t<tr><th scope=row>bortezomib__PC3__trt_cp</th><td>bortezomib__PC3__trt_cp             </td><td>-3.855000</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "</dd>\n",
       "\t<dt>$HOXC5</dt>\n",
       "\t\t<dd><table class=\"dataframe\">\n",
       "<caption>A data.frame: 49 × 2</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>drug</th><th scope=col>zscore</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>aminomethyltransferase__HA1E__trt_cp</th><td>aminomethyltransferase__HA1E__trt_cp  </td><td>-2.349426</td></tr>\n",
       "\t<tr><th scope=row>ARP-101__HA1E__trt_cp</th><td>ARP-101__HA1E__trt_cp                 </td><td>-2.420850</td></tr>\n",
       "\t<tr><th scope=row>homoharringtonine__HA1E__trt_cp</th><td>homoharringtonine__HA1E__trt_cp       </td><td>-2.545411</td></tr>\n",
       "\t<tr><th scope=row>CFM-1571__HCC515__trt_cp</th><td>CFM-1571__HCC515__trt_cp              </td><td>-2.027797</td></tr>\n",
       "\t<tr><th scope=row>apoptosis-activator-II__HCC515__trt_cp</th><td>apoptosis-activator-II__HCC515__trt_cp</td><td>-2.027338</td></tr>\n",
       "\t<tr><th scope=row>puromycin__VCAP__trt_cp</th><td>puromycin__VCAP__trt_cp               </td><td>-3.208967</td></tr>\n",
       "\t<tr><th scope=row>NSC-632839__VCAP__trt_cp</th><td>NSC-632839__VCAP__trt_cp              </td><td>-2.437900</td></tr>\n",
       "\t<tr><th scope=row>NNC-711__VCAP__trt_cp</th><td>NNC-711__VCAP__trt_cp                 </td><td>-2.587158</td></tr>\n",
       "\t<tr><th scope=row>MG-132__VCAP__trt_cp</th><td>MG-132__VCAP__trt_cp                  </td><td>-2.497801</td></tr>\n",
       "\t<tr><th scope=row>Ro-15-4513__VCAP__trt_cp</th><td>Ro-15-4513__VCAP__trt_cp              </td><td>-2.462467</td></tr>\n",
       "\t<tr><th scope=row>R-59022__HA1E__trt_cp</th><td>R-59022__HA1E__trt_cp                 </td><td>-2.440392</td></tr>\n",
       "\t<tr><th scope=row>cucurbitacin-i__MCF7__trt_cp</th><td>cucurbitacin-i__MCF7__trt_cp          </td><td>-2.504937</td></tr>\n",
       "\t<tr><th scope=row>SCH-79797__MCF7__trt_cp</th><td>SCH-79797__MCF7__trt_cp               </td><td>-3.103155</td></tr>\n",
       "\t<tr><th scope=row>BRD-K19290969__A549__trt_cp</th><td>BRD-K19290969__A549__trt_cp           </td><td>-2.442208</td></tr>\n",
       "\t<tr><th scope=row>BIX-02188__VCAP__trt_cp</th><td>BIX-02188__VCAP__trt_cp               </td><td>-2.021193</td></tr>\n",
       "\t<tr><th scope=row>BRD-A98444709__A549__trt_cp</th><td>BRD-A98444709__A549__trt_cp           </td><td>-2.181950</td></tr>\n",
       "\t<tr><th scope=row>BRD-K18726304__MCF7__trt_cp</th><td>BRD-K18726304__MCF7__trt_cp           </td><td>-2.498750</td></tr>\n",
       "\t<tr><th scope=row>toremifene__MCF7__trt_cp</th><td>toremifene__MCF7__trt_cp              </td><td>-2.111762</td></tr>\n",
       "\t<tr><th scope=row>BRD-K32896438__MCF7__trt_cp</th><td>BRD-K32896438__MCF7__trt_cp           </td><td>-2.568452</td></tr>\n",
       "\t<tr><th scope=row>RAN-27__NEU__trt_cp</th><td>RAN-27__NEU__trt_cp                   </td><td>-2.057970</td></tr>\n",
       "\t<tr><th scope=row>BRD-K44893543__NEU__trt_cp</th><td>BRD-K44893543__NEU__trt_cp            </td><td>-2.403568</td></tr>\n",
       "\t<tr><th scope=row>cytochalasin-d__MCF7__trt_cp</th><td>cytochalasin-d__MCF7__trt_cp          </td><td>-2.524929</td></tr>\n",
       "\t<tr><th scope=row>ST-4029010__NEU__trt_cp</th><td>ST-4029010__NEU__trt_cp               </td><td>-2.160550</td></tr>\n",
       "\t<tr><th scope=row>sorafenib__VCAP__trt_cp</th><td>sorafenib__VCAP__trt_cp               </td><td>-2.387828</td></tr>\n",
       "\t<tr><th scope=row>BG-FA-0953__VCAP__trt_cp</th><td>BG-FA-0953__VCAP__trt_cp              </td><td>-2.010978</td></tr>\n",
       "\t<tr><th scope=row>WYE-354__ASC__trt_cp</th><td>WYE-354__ASC__trt_cp                  </td><td>-2.030976</td></tr>\n",
       "\t<tr><th scope=row>WYE-125132__MCF7__trt_cp</th><td>WYE-125132__MCF7__trt_cp              </td><td>-2.019033</td></tr>\n",
       "\t<tr><th scope=row>verrucarin-a__NEU__trt_cp</th><td>verrucarin-a__NEU__trt_cp             </td><td>-2.535550</td></tr>\n",
       "\t<tr><th scope=row>mirin__VCAP__trt_cp</th><td>mirin__VCAP__trt_cp                   </td><td>-2.051119</td></tr>\n",
       "\t<tr><th scope=row>CGP-71683__MCF7__trt_cp</th><td>CGP-71683__MCF7__trt_cp               </td><td>-2.191356</td></tr>\n",
       "\t<tr><th scope=row>NSC-663284__PHH__trt_cp</th><td>NSC-663284__PHH__trt_cp               </td><td>-2.232050</td></tr>\n",
       "\t<tr><th scope=row>proadifen__ASC__trt_cp</th><td>proadifen__ASC__trt_cp                </td><td>-2.171099</td></tr>\n",
       "\t<tr><th scope=row>anisomycin__NEU__trt_cp</th><td>anisomycin__NEU__trt_cp               </td><td>-2.530992</td></tr>\n",
       "\t<tr><th scope=row>formoterol__SKB__trt_cp</th><td>formoterol__SKB__trt_cp               </td><td>-2.052984</td></tr>\n",
       "\t<tr><th scope=row>FCCP__MCF7__trt_cp</th><td>FCCP__MCF7__trt_cp                    </td><td>-2.068842</td></tr>\n",
       "\t<tr><th scope=row>diphenyleneiodonium__MCF7__trt_cp</th><td>diphenyleneiodonium__MCF7__trt_cp     </td><td>-2.738179</td></tr>\n",
       "\t<tr><th scope=row>NSC-94258__MCF7__trt_cp</th><td>NSC-94258__MCF7__trt_cp               </td><td>-2.348442</td></tr>\n",
       "\t<tr><th scope=row>SQ-22536__NPC__trt_cp</th><td>SQ-22536__NPC__trt_cp                 </td><td>-2.024650</td></tr>\n",
       "\t<tr><th scope=row>pyrvinium__MCF7__trt_cp</th><td>pyrvinium__MCF7__trt_cp               </td><td>-2.287450</td></tr>\n",
       "\t<tr><th scope=row>BRD-K00835201__NEU__trt_cp</th><td>BRD-K00835201__NEU__trt_cp            </td><td>-2.013800</td></tr>\n",
       "\t<tr><th scope=row>BRD-K75264577__NEU__trt_cp</th><td>BRD-K75264577__NEU__trt_cp            </td><td>-2.051050</td></tr>\n",
       "\t<tr><th scope=row>BRD-K01477275__NPC__trt_cp</th><td>BRD-K01477275__NPC__trt_cp            </td><td>-2.038408</td></tr>\n",
       "\t<tr><th scope=row>BRD-K02519835__VCAP__trt_cp</th><td>BRD-K02519835__VCAP__trt_cp           </td><td>-2.148807</td></tr>\n",
       "\t<tr><th scope=row>motesanib__HS578T__trt_cp</th><td>motesanib__HS578T__trt_cp             </td><td>-2.047123</td></tr>\n",
       "\t<tr><th scope=row>SYK-inhibitor__SKBR3__trt_cp</th><td>SYK-inhibitor__SKBR3__trt_cp          </td><td>-2.655849</td></tr>\n",
       "\t<tr><th scope=row>ENMD-2076__A375__trt_cp</th><td>ENMD-2076__A375__trt_cp               </td><td>-2.061680</td></tr>\n",
       "\t<tr><th scope=row>BRD-K99636700__HCC515__trt_cp</th><td>BRD-K99636700__HCC515__trt_cp         </td><td>-2.166222</td></tr>\n",
       "\t<tr><th scope=row>apicidin__HEPG2__trt_cp</th><td>apicidin__HEPG2__trt_cp               </td><td>-2.335700</td></tr>\n",
       "\t<tr><th scope=row>avrainvillamide-analog-4__MCF7__trt_cp</th><td>avrainvillamide-analog-4__MCF7__trt_cp</td><td>-2.152519</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "</dd>\n",
       "</dl>\n"
      ],
      "text/latex": [
       "\\begin{description}\n",
       "\\item[\\$VENTX] A data.frame: 80 × 2\n",
       "\\begin{tabular}{r|ll}\n",
       "  & drug & zscore\\\\\n",
       "  & <chr> & <dbl>\\\\\n",
       "\\hline\n",
       "\tbutoconazole\\_\\_HCC515\\_\\_trt\\_cp & butoconazole\\_\\_HCC515\\_\\_trt\\_cp & -2.043097\\\\\n",
       "\tamcinonide\\_\\_VCAP\\_\\_trt\\_cp & amcinonide\\_\\_VCAP\\_\\_trt\\_cp     & -2.013700\\\\\n",
       "\tverteporfin\\_\\_VCAP\\_\\_trt\\_cp & verteporfin\\_\\_VCAP\\_\\_trt\\_cp    & -2.372383\\\\\n",
       "\tnapelline\\_\\_HT29\\_\\_trt\\_cp & napelline\\_\\_HT29\\_\\_trt\\_cp      & -2.024536\\\\\n",
       "\tclioquinol\\_\\_HT29\\_\\_trt\\_cp & clioquinol\\_\\_HT29\\_\\_trt\\_cp     & -2.086267\\\\\n",
       "\tNS-3694\\_\\_VCAP\\_\\_trt\\_cp & NS-3694\\_\\_VCAP\\_\\_trt\\_cp        & -2.178900\\\\\n",
       "\tAS-605240\\_\\_VCAP\\_\\_trt\\_cp & AS-605240\\_\\_VCAP\\_\\_trt\\_cp      & -2.451528\\\\\n",
       "\tSJ-172550\\_\\_VCAP\\_\\_trt\\_cp & SJ-172550\\_\\_VCAP\\_\\_trt\\_cp      & -2.893954\\\\\n",
       "\tJAS07-005\\_\\_VCAP\\_\\_trt\\_cp & JAS07-005\\_\\_VCAP\\_\\_trt\\_cp      & -2.086582\\\\\n",
       "\tBRD-A38425832\\_\\_MCF7\\_\\_trt\\_cp & BRD-A38425832\\_\\_MCF7\\_\\_trt\\_cp  & -2.438600\\\\\n",
       "\tBRD-K32827536\\_\\_PC3\\_\\_trt\\_cp & BRD-K32827536\\_\\_PC3\\_\\_trt\\_cp   & -2.027371\\\\\n",
       "\tBRD-K48844671\\_\\_PC3\\_\\_trt\\_cp & BRD-K48844671\\_\\_PC3\\_\\_trt\\_cp   & -2.115793\\\\\n",
       "\tBRD-K23165181\\_\\_VCAP\\_\\_trt\\_cp & BRD-K23165181\\_\\_VCAP\\_\\_trt\\_cp  & -2.151439\\\\\n",
       "\tBRD-K58247702\\_\\_VCAP\\_\\_trt\\_cp & BRD-K58247702\\_\\_VCAP\\_\\_trt\\_cp  & -2.014121\\\\\n",
       "\tBRD-K70917163\\_\\_VCAP\\_\\_trt\\_cp & BRD-K70917163\\_\\_VCAP\\_\\_trt\\_cp  & -2.195663\\\\\n",
       "\tKU-C104140\\_\\_A549\\_\\_trt\\_cp & KU-C104140\\_\\_A549\\_\\_trt\\_cp     & -2.076100\\\\\n",
       "\tBRD-A11095214\\_\\_MCF7\\_\\_trt\\_cp & BRD-A11095214\\_\\_MCF7\\_\\_trt\\_cp  & -2.200500\\\\\n",
       "\tBRD-K33182644\\_\\_MCF7\\_\\_trt\\_cp & BRD-K33182644\\_\\_MCF7\\_\\_trt\\_cp  & -2.137250\\\\\n",
       "\tBRD-K98991361\\_\\_A549\\_\\_trt\\_cp & BRD-K98991361\\_\\_A549\\_\\_trt\\_cp  & -2.161300\\\\\n",
       "\toxcarbazepine\\_\\_MCF7\\_\\_trt\\_cp & oxcarbazepine\\_\\_MCF7\\_\\_trt\\_cp  & -2.080350\\\\\n",
       "\tlansoprazole\\_\\_VCAP\\_\\_trt\\_cp & lansoprazole\\_\\_VCAP\\_\\_trt\\_cp   & -2.672177\\\\\n",
       "\tkitasamycin\\_\\_VCAP\\_\\_trt\\_cp & kitasamycin\\_\\_VCAP\\_\\_trt\\_cp    & -2.771939\\\\\n",
       "\tBRD-A16581344\\_\\_A549\\_\\_trt\\_cp & BRD-A16581344\\_\\_A549\\_\\_trt\\_cp  & -2.207200\\\\\n",
       "\tBRD-K88556033\\_\\_A549\\_\\_trt\\_cp & BRD-K88556033\\_\\_A549\\_\\_trt\\_cp  & -2.038800\\\\\n",
       "\tRAN-27\\_\\_NEU\\_\\_trt\\_cp & RAN-27\\_\\_NEU\\_\\_trt\\_cp          & -2.076294\\\\\n",
       "\tBRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp   & -2.608974\\\\\n",
       "\tBRD-K58279162\\_\\_NEU\\_\\_trt\\_cp & BRD-K58279162\\_\\_NEU\\_\\_trt\\_cp   & -2.688838\\\\\n",
       "\tBRD-K14316227\\_\\_NPC\\_\\_trt\\_cp & BRD-K14316227\\_\\_NPC\\_\\_trt\\_cp   & -2.204158\\\\\n",
       "\ttreprostinil\\_\\_PHH\\_\\_trt\\_cp & treprostinil\\_\\_PHH\\_\\_trt\\_cp    & -2.756694\\\\\n",
       "\tBRD-K82971429\\_\\_PHH\\_\\_trt\\_cp & BRD-K82971429\\_\\_PHH\\_\\_trt\\_cp   & -2.028831\\\\\n",
       "\t⋮ & ⋮ & ⋮\\\\\n",
       "\tNSC-663284\\_\\_PHH\\_\\_trt\\_cp & NSC-663284\\_\\_PHH\\_\\_trt\\_cp         & -2.211250\\\\\n",
       "\tzoxazolamine\\_\\_PHH\\_\\_trt\\_cp & zoxazolamine\\_\\_PHH\\_\\_trt\\_cp       & -2.148100\\\\\n",
       "\tnateglinide\\_\\_PHH\\_\\_trt\\_cp & nateglinide\\_\\_PHH\\_\\_trt\\_cp        & -2.026000\\\\\n",
       "\tLFM-A13\\_\\_NEU\\_\\_trt\\_cp & LFM-A13\\_\\_NEU\\_\\_trt\\_cp            & -2.864500\\\\\n",
       "\tBML-257\\_\\_NEU\\_\\_trt\\_cp & BML-257\\_\\_NEU\\_\\_trt\\_cp            & -3.350300\\\\\n",
       "\tlamotrigine\\_\\_NEU\\_\\_trt\\_cp & lamotrigine\\_\\_NEU\\_\\_trt\\_cp        & -2.059334\\\\\n",
       "\tIC-261\\_\\_PHH\\_\\_trt\\_cp & IC-261\\_\\_PHH\\_\\_trt\\_cp             & -2.089171\\\\\n",
       "\tL-701252\\_\\_PHH\\_\\_trt\\_cp & L-701252\\_\\_PHH\\_\\_trt\\_cp           & -3.265500\\\\\n",
       "\tmometasone\\_\\_PHH\\_\\_trt\\_cp & mometasone\\_\\_PHH\\_\\_trt\\_cp         & -2.173689\\\\\n",
       "\tscoulerine\\_\\_PHH\\_\\_trt\\_cp & scoulerine\\_\\_PHH\\_\\_trt\\_cp         & -2.078122\\\\\n",
       "\tdihydroergotamine\\_\\_PHH\\_\\_trt\\_cp & dihydroergotamine\\_\\_PHH\\_\\_trt\\_cp  & -2.580976\\\\\n",
       "\tdipyridamole\\_\\_PHH\\_\\_trt\\_cp & dipyridamole\\_\\_PHH\\_\\_trt\\_cp       & -2.045686\\\\\n",
       "\ttyrphostin-AG-825\\_\\_MCF7\\_\\_trt\\_cp & tyrphostin-AG-825\\_\\_MCF7\\_\\_trt\\_cp & -2.394913\\\\\n",
       "\trosmarinic-acid\\_\\_NPC\\_\\_trt\\_cp & rosmarinic-acid\\_\\_NPC\\_\\_trt\\_cp    & -2.170692\\\\\n",
       "\tamthamine\\_\\_PHH\\_\\_trt\\_cp & amthamine\\_\\_PHH\\_\\_trt\\_cp          & -2.258550\\\\\n",
       "\tNAN-190\\_\\_PHH\\_\\_trt\\_cp & NAN-190\\_\\_PHH\\_\\_trt\\_cp            & -4.584300\\\\\n",
       "\tBRD-K24053449\\_\\_MCF7\\_\\_trt\\_cp & BRD-K24053449\\_\\_MCF7\\_\\_trt\\_cp     & -2.124968\\\\\n",
       "\tBRD-K88278225\\_\\_PC3\\_\\_trt\\_cp & BRD-K88278225\\_\\_PC3\\_\\_trt\\_cp      & -5.143122\\\\\n",
       "\tBRD-K03358980\\_\\_VCAP\\_\\_trt\\_cp & BRD-K03358980\\_\\_VCAP\\_\\_trt\\_cp     & -2.230576\\\\\n",
       "\tBRD-K06592610\\_\\_VCAP\\_\\_trt\\_cp & BRD-K06592610\\_\\_VCAP\\_\\_trt\\_cp     & -2.063635\\\\\n",
       "\tRDR-01440SC\\_\\_VCAP\\_\\_trt\\_cp & RDR-01440SC\\_\\_VCAP\\_\\_trt\\_cp       & -2.042054\\\\\n",
       "\tBRD-K76691125\\_\\_VCAP\\_\\_trt\\_cp & BRD-K76691125\\_\\_VCAP\\_\\_trt\\_cp     & -2.113669\\\\\n",
       "\ttubacin\\_\\_VCAP\\_\\_trt\\_cp & tubacin\\_\\_VCAP\\_\\_trt\\_cp           & -3.499640\\\\\n",
       "\tBRD-K47512679\\_\\_NPC\\_\\_trt\\_cp & BRD-K47512679\\_\\_NPC\\_\\_trt\\_cp      & -2.032956\\\\\n",
       "\tBRD-K05353139\\_\\_HT29\\_\\_trt\\_cp & BRD-K05353139\\_\\_HT29\\_\\_trt\\_cp     & -2.013206\\\\\n",
       "\tBRD-K48598367\\_\\_NEU\\_\\_trt\\_cp & BRD-K48598367\\_\\_NEU\\_\\_trt\\_cp      & -2.556500\\\\\n",
       "\tSA-419083\\_\\_NPC\\_\\_trt\\_cp & SA-419083\\_\\_NPC\\_\\_trt\\_cp          & -2.028479\\\\\n",
       "\tBRD-K28772322\\_\\_VCAP\\_\\_trt\\_cp & BRD-K28772322\\_\\_VCAP\\_\\_trt\\_cp     & -2.263741\\\\\n",
       "\tnocodazole\\_\\_FIBRNPC\\_\\_trt\\_cp & nocodazole\\_\\_FIBRNPC\\_\\_trt\\_cp     & -2.172350\\\\\n",
       "\tAVA\\_\\_HA1E\\_\\_trt\\_cp & AVA\\_\\_HA1E\\_\\_trt\\_cp               & -2.028199\\\\\n",
       "\\end{tabular}\n",
       "\n",
       "\\item[\\$ISL1] A data.frame: 197 × 2\n",
       "\\begin{tabular}{r|ll}\n",
       "  & drug & zscore\\\\\n",
       "  & <chr> & <dbl>\\\\\n",
       "\\hline\n",
       "\tBRD-K26684619\\_\\_CD34\\_\\_trt\\_cp & BRD-K26684619\\_\\_CD34\\_\\_trt\\_cp          & -2.040950\\\\\n",
       "\tBRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp          & -2.227154\\\\\n",
       "\tMRS-1845\\_\\_HCC515\\_\\_trt\\_cp & MRS-1845\\_\\_HCC515\\_\\_trt\\_cp             & -2.417191\\\\\n",
       "\tmelperone\\_\\_HCC515\\_\\_trt\\_cp & melperone\\_\\_HCC515\\_\\_trt\\_cp            & -2.385237\\\\\n",
       "\tFCCP\\_\\_HCC515\\_\\_trt\\_cp & FCCP\\_\\_HCC515\\_\\_trt\\_cp                 & -2.176191\\\\\n",
       "\tBCL2-inhibitor\\_\\_VCAP\\_\\_trt\\_cp & BCL2-inhibitor\\_\\_VCAP\\_\\_trt\\_cp         & -2.520154\\\\\n",
       "\tubenimex\\_\\_VCAP\\_\\_trt\\_cp & ubenimex\\_\\_VCAP\\_\\_trt\\_cp               & -2.167702\\\\\n",
       "\tepitestosterone\\_\\_VCAP\\_\\_trt\\_cp & epitestosterone\\_\\_VCAP\\_\\_trt\\_cp        & -2.142600\\\\\n",
       "\tprocainamide\\_\\_VCAP\\_\\_trt\\_cp & procainamide\\_\\_VCAP\\_\\_trt\\_cp           & -2.136900\\\\\n",
       "\tanagrelide\\_\\_HA1E\\_\\_trt\\_cp & anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & -2.888882\\\\\n",
       "\tbithionol\\_\\_HCC515\\_\\_trt\\_cp & bithionol\\_\\_HCC515\\_\\_trt\\_cp            & -2.335168\\\\\n",
       "\tGW-1929\\_\\_VCAP\\_\\_trt\\_cp & GW-1929\\_\\_VCAP\\_\\_trt\\_cp                & -3.890623\\\\\n",
       "\tCMPD-1\\_\\_A375\\_\\_trt\\_cp & CMPD-1\\_\\_A375\\_\\_trt\\_cp                 & -2.118605\\\\\n",
       "\tST-638\\_\\_HA1E\\_\\_trt\\_cp & ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & -2.139165\\\\\n",
       "\tfluocinolone-acetonide\\_\\_HT29\\_\\_trt\\_cp & fluocinolone-acetonide\\_\\_HT29\\_\\_trt\\_cp & -2.311850\\\\\n",
       "\tmitoxantrone\\_\\_HT29\\_\\_trt\\_cp & mitoxantrone\\_\\_HT29\\_\\_trt\\_cp           & -2.173384\\\\\n",
       "\tL-168049\\_\\_VCAP\\_\\_trt\\_cp & L-168049\\_\\_VCAP\\_\\_trt\\_cp               & -2.498789\\\\\n",
       "\tBX-795\\_\\_HT29\\_\\_trt\\_cp & BX-795\\_\\_HT29\\_\\_trt\\_cp                 & -2.146887\\\\\n",
       "\tcucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp         & -2.131572\\\\\n",
       "\tCT-200783\\_\\_VCAP\\_\\_trt\\_cp & CT-200783\\_\\_VCAP\\_\\_trt\\_cp              & -2.346538\\\\\n",
       "\tBRD-K60870698\\_\\_A375\\_\\_trt\\_cp & BRD-K60870698\\_\\_A375\\_\\_trt\\_cp          & -2.611861\\\\\n",
       "\tBRD-K84203638\\_\\_A375\\_\\_trt\\_cp & BRD-K84203638\\_\\_A375\\_\\_trt\\_cp          & -2.241982\\\\\n",
       "\tBRD-K05153001\\_\\_A549\\_\\_trt\\_cp & BRD-K05153001\\_\\_A549\\_\\_trt\\_cp          & -2.140815\\\\\n",
       "\tBRD-K85275009\\_\\_A549\\_\\_trt\\_cp & BRD-K85275009\\_\\_A549\\_\\_trt\\_cp          & -4.711900\\\\\n",
       "\tBRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & -2.309873\\\\\n",
       "\tBRD-A58924247\\_\\_HT29\\_\\_trt\\_cp & BRD-A58924247\\_\\_HT29\\_\\_trt\\_cp          & -2.229404\\\\\n",
       "\tBRD-K91691979\\_\\_PC3\\_\\_trt\\_cp & BRD-K91691979\\_\\_PC3\\_\\_trt\\_cp           & -2.309459\\\\\n",
       "\tBRD-K19735876\\_\\_A375\\_\\_trt\\_cp & BRD-K19735876\\_\\_A375\\_\\_trt\\_cp          & -2.083350\\\\\n",
       "\tBRD-A21406558\\_\\_MCF7\\_\\_trt\\_cp & BRD-A21406558\\_\\_MCF7\\_\\_trt\\_cp          & -2.156250\\\\\n",
       "\tBRD-K07259155\\_\\_MCF7\\_\\_trt\\_cp & BRD-K07259155\\_\\_MCF7\\_\\_trt\\_cp          & -2.299050\\\\\n",
       "\t⋮ & ⋮ & ⋮\\\\\n",
       "\tSR-12813\\_\\_NEU\\_\\_trt\\_cp & SR-12813\\_\\_NEU\\_\\_trt\\_cp                & -2.061450\\\\\n",
       "\tLBH-589\\_\\_NEU\\_\\_trt\\_cp & LBH-589\\_\\_NEU\\_\\_trt\\_cp                 & -2.051542\\\\\n",
       "\tBG-1003\\_\\_NPC\\_\\_trt\\_cp & BG-1003\\_\\_NPC\\_\\_trt\\_cp                 & -2.050464\\\\\n",
       "\tLBH-589\\_\\_NPC\\_\\_trt\\_cp & LBH-589\\_\\_NPC\\_\\_trt\\_cp                 & -2.351810\\\\\n",
       "\tBG-1008\\_\\_NEU\\_\\_trt\\_cp & BG-1008\\_\\_NEU\\_\\_trt\\_cp                 & -2.506527\\\\\n",
       "\ttemozolomide\\_\\_NEU\\_\\_trt\\_cp & temozolomide\\_\\_NEU\\_\\_trt\\_cp            & -2.358148\\\\\n",
       "\tBG-1005\\_\\_NEU\\_\\_trt\\_cp & BG-1005\\_\\_NEU\\_\\_trt\\_cp                 & -2.408175\\\\\n",
       "\tBG-1025\\_\\_NEU\\_\\_trt\\_cp & BG-1025\\_\\_NEU\\_\\_trt\\_cp                 & -2.330200\\\\\n",
       "\tC2-dihydroceramide\\_\\_NEU\\_\\_trt\\_cp & C2-dihydroceramide\\_\\_NEU\\_\\_trt\\_cp      & -2.060200\\\\\n",
       "\tBG-1030\\_\\_NEU\\_\\_trt\\_cp & BG-1030\\_\\_NEU\\_\\_trt\\_cp                 & -2.047566\\\\\n",
       "\toxamflatin\\_\\_NPC\\_\\_trt\\_cp & oxamflatin\\_\\_NPC\\_\\_trt\\_cp              & -2.670142\\\\\n",
       "\tBG-1029\\_\\_NPC\\_\\_trt\\_cp & BG-1029\\_\\_NPC\\_\\_trt\\_cp                 & -2.168213\\\\\n",
       "\tBG-1006\\_\\_NPC\\_\\_trt\\_cp & BG-1006\\_\\_NPC\\_\\_trt\\_cp                 & -2.664152\\\\\n",
       "\tBML-284\\_\\_NPC\\_\\_trt\\_cp & BML-284\\_\\_NPC\\_\\_trt\\_cp                 & -4.036828\\\\\n",
       "\tM-344\\_\\_NPC\\_\\_trt\\_cp & M-344\\_\\_NPC\\_\\_trt\\_cp                   & -2.041860\\\\\n",
       "\tBG-1025\\_\\_NPC\\_\\_trt\\_cp & BG-1025\\_\\_NPC\\_\\_trt\\_cp                 & -2.107575\\\\\n",
       "\tBG-1026\\_\\_NPC\\_\\_trt\\_cp & BG-1026\\_\\_NPC\\_\\_trt\\_cp                 & -2.440128\\\\\n",
       "\tNCH-51\\_\\_NPC\\_\\_trt\\_cp & NCH-51\\_\\_NPC\\_\\_trt\\_cp                  & -2.122013\\\\\n",
       "\tBG-1007\\_\\_NPC\\_\\_trt\\_cp & BG-1007\\_\\_NPC\\_\\_trt\\_cp                 & -2.229874\\\\\n",
       "\tBG-1028\\_\\_NPC\\_\\_trt\\_cp & BG-1028\\_\\_NPC\\_\\_trt\\_cp                 & -2.391268\\\\\n",
       "\tBG-1027\\_\\_NPC\\_\\_trt\\_cp & BG-1027\\_\\_NPC\\_\\_trt\\_cp                 & -2.334610\\\\\n",
       "\ttert-butylhydroquinone\\_\\_MCF7\\_\\_trt\\_cp & tert-butylhydroquinone\\_\\_MCF7\\_\\_trt\\_cp & -3.080953\\\\\n",
       "\tpanobinostat\\_\\_A375\\_\\_trt\\_cp & panobinostat\\_\\_A375\\_\\_trt\\_cp           & -2.063759\\\\\n",
       "\tstaurosporine\\_\\_A375\\_\\_trt\\_cp & staurosporine\\_\\_A375\\_\\_trt\\_cp          & -3.507200\\\\\n",
       "\tapicidin\\_\\_A375\\_\\_trt\\_cp & apicidin\\_\\_A375\\_\\_trt\\_cp               & -2.681550\\\\\n",
       "\tBRD-K57064803\\_\\_MCF7\\_\\_trt\\_cp & BRD-K57064803\\_\\_MCF7\\_\\_trt\\_cp          & -2.356925\\\\\n",
       "\talpha-tocopherol\\_\\_MCF7\\_\\_trt\\_cp & alpha-tocopherol\\_\\_MCF7\\_\\_trt\\_cp       & -2.502400\\\\\n",
       "\tJMW-MITF1\\_\\_MCF7\\_\\_trt\\_cp & JMW-MITF1\\_\\_MCF7\\_\\_trt\\_cp              & -2.199600\\\\\n",
       "\talpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp & alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp        & -2.310900\\\\\n",
       "\tbortezomib\\_\\_PC3\\_\\_trt\\_cp & bortezomib\\_\\_PC3\\_\\_trt\\_cp              & -3.855000\\\\\n",
       "\\end{tabular}\n",
       "\n",
       "\\item[\\$HOXC5] A data.frame: 49 × 2\n",
       "\\begin{tabular}{r|ll}\n",
       "  & drug & zscore\\\\\n",
       "  & <chr> & <dbl>\\\\\n",
       "\\hline\n",
       "\taminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp   & -2.349426\\\\\n",
       "\tARP-101\\_\\_HA1E\\_\\_trt\\_cp & ARP-101\\_\\_HA1E\\_\\_trt\\_cp                  & -2.420850\\\\\n",
       "\thomoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp        & -2.545411\\\\\n",
       "\tCFM-1571\\_\\_HCC515\\_\\_trt\\_cp & CFM-1571\\_\\_HCC515\\_\\_trt\\_cp               & -2.027797\\\\\n",
       "\tapoptosis-activator-II\\_\\_HCC515\\_\\_trt\\_cp & apoptosis-activator-II\\_\\_HCC515\\_\\_trt\\_cp & -2.027338\\\\\n",
       "\tpuromycin\\_\\_VCAP\\_\\_trt\\_cp & puromycin\\_\\_VCAP\\_\\_trt\\_cp                & -3.208967\\\\\n",
       "\tNSC-632839\\_\\_VCAP\\_\\_trt\\_cp & NSC-632839\\_\\_VCAP\\_\\_trt\\_cp               & -2.437900\\\\\n",
       "\tNNC-711\\_\\_VCAP\\_\\_trt\\_cp & NNC-711\\_\\_VCAP\\_\\_trt\\_cp                  & -2.587158\\\\\n",
       "\tMG-132\\_\\_VCAP\\_\\_trt\\_cp & MG-132\\_\\_VCAP\\_\\_trt\\_cp                   & -2.497801\\\\\n",
       "\tRo-15-4513\\_\\_VCAP\\_\\_trt\\_cp & Ro-15-4513\\_\\_VCAP\\_\\_trt\\_cp               & -2.462467\\\\\n",
       "\tR-59022\\_\\_HA1E\\_\\_trt\\_cp & R-59022\\_\\_HA1E\\_\\_trt\\_cp                  & -2.440392\\\\\n",
       "\tcucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp & cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp           & -2.504937\\\\\n",
       "\tSCH-79797\\_\\_MCF7\\_\\_trt\\_cp & SCH-79797\\_\\_MCF7\\_\\_trt\\_cp                & -3.103155\\\\\n",
       "\tBRD-K19290969\\_\\_A549\\_\\_trt\\_cp & BRD-K19290969\\_\\_A549\\_\\_trt\\_cp            & -2.442208\\\\\n",
       "\tBIX-02188\\_\\_VCAP\\_\\_trt\\_cp & BIX-02188\\_\\_VCAP\\_\\_trt\\_cp                & -2.021193\\\\\n",
       "\tBRD-A98444709\\_\\_A549\\_\\_trt\\_cp & BRD-A98444709\\_\\_A549\\_\\_trt\\_cp            & -2.181950\\\\\n",
       "\tBRD-K18726304\\_\\_MCF7\\_\\_trt\\_cp & BRD-K18726304\\_\\_MCF7\\_\\_trt\\_cp            & -2.498750\\\\\n",
       "\ttoremifene\\_\\_MCF7\\_\\_trt\\_cp & toremifene\\_\\_MCF7\\_\\_trt\\_cp               & -2.111762\\\\\n",
       "\tBRD-K32896438\\_\\_MCF7\\_\\_trt\\_cp & BRD-K32896438\\_\\_MCF7\\_\\_trt\\_cp            & -2.568452\\\\\n",
       "\tRAN-27\\_\\_NEU\\_\\_trt\\_cp & RAN-27\\_\\_NEU\\_\\_trt\\_cp                    & -2.057970\\\\\n",
       "\tBRD-K44893543\\_\\_NEU\\_\\_trt\\_cp & BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp             & -2.403568\\\\\n",
       "\tcytochalasin-d\\_\\_MCF7\\_\\_trt\\_cp & cytochalasin-d\\_\\_MCF7\\_\\_trt\\_cp           & -2.524929\\\\\n",
       "\tST-4029010\\_\\_NEU\\_\\_trt\\_cp & ST-4029010\\_\\_NEU\\_\\_trt\\_cp                & -2.160550\\\\\n",
       "\tsorafenib\\_\\_VCAP\\_\\_trt\\_cp & sorafenib\\_\\_VCAP\\_\\_trt\\_cp                & -2.387828\\\\\n",
       "\tBG-FA-0953\\_\\_VCAP\\_\\_trt\\_cp & BG-FA-0953\\_\\_VCAP\\_\\_trt\\_cp               & -2.010978\\\\\n",
       "\tWYE-354\\_\\_ASC\\_\\_trt\\_cp & WYE-354\\_\\_ASC\\_\\_trt\\_cp                   & -2.030976\\\\\n",
       "\tWYE-125132\\_\\_MCF7\\_\\_trt\\_cp & WYE-125132\\_\\_MCF7\\_\\_trt\\_cp               & -2.019033\\\\\n",
       "\tverrucarin-a\\_\\_NEU\\_\\_trt\\_cp & verrucarin-a\\_\\_NEU\\_\\_trt\\_cp              & -2.535550\\\\\n",
       "\tmirin\\_\\_VCAP\\_\\_trt\\_cp & mirin\\_\\_VCAP\\_\\_trt\\_cp                    & -2.051119\\\\\n",
       "\tCGP-71683\\_\\_MCF7\\_\\_trt\\_cp & CGP-71683\\_\\_MCF7\\_\\_trt\\_cp                & -2.191356\\\\\n",
       "\tNSC-663284\\_\\_PHH\\_\\_trt\\_cp & NSC-663284\\_\\_PHH\\_\\_trt\\_cp                & -2.232050\\\\\n",
       "\tproadifen\\_\\_ASC\\_\\_trt\\_cp & proadifen\\_\\_ASC\\_\\_trt\\_cp                 & -2.171099\\\\\n",
       "\tanisomycin\\_\\_NEU\\_\\_trt\\_cp & anisomycin\\_\\_NEU\\_\\_trt\\_cp                & -2.530992\\\\\n",
       "\tformoterol\\_\\_SKB\\_\\_trt\\_cp & formoterol\\_\\_SKB\\_\\_trt\\_cp                & -2.052984\\\\\n",
       "\tFCCP\\_\\_MCF7\\_\\_trt\\_cp & FCCP\\_\\_MCF7\\_\\_trt\\_cp                     & -2.068842\\\\\n",
       "\tdiphenyleneiodonium\\_\\_MCF7\\_\\_trt\\_cp & diphenyleneiodonium\\_\\_MCF7\\_\\_trt\\_cp      & -2.738179\\\\\n",
       "\tNSC-94258\\_\\_MCF7\\_\\_trt\\_cp & NSC-94258\\_\\_MCF7\\_\\_trt\\_cp                & -2.348442\\\\\n",
       "\tSQ-22536\\_\\_NPC\\_\\_trt\\_cp & SQ-22536\\_\\_NPC\\_\\_trt\\_cp                  & -2.024650\\\\\n",
       "\tpyrvinium\\_\\_MCF7\\_\\_trt\\_cp & pyrvinium\\_\\_MCF7\\_\\_trt\\_cp                & -2.287450\\\\\n",
       "\tBRD-K00835201\\_\\_NEU\\_\\_trt\\_cp & BRD-K00835201\\_\\_NEU\\_\\_trt\\_cp             & -2.013800\\\\\n",
       "\tBRD-K75264577\\_\\_NEU\\_\\_trt\\_cp & BRD-K75264577\\_\\_NEU\\_\\_trt\\_cp             & -2.051050\\\\\n",
       "\tBRD-K01477275\\_\\_NPC\\_\\_trt\\_cp & BRD-K01477275\\_\\_NPC\\_\\_trt\\_cp             & -2.038408\\\\\n",
       "\tBRD-K02519835\\_\\_VCAP\\_\\_trt\\_cp & BRD-K02519835\\_\\_VCAP\\_\\_trt\\_cp            & -2.148807\\\\\n",
       "\tmotesanib\\_\\_HS578T\\_\\_trt\\_cp & motesanib\\_\\_HS578T\\_\\_trt\\_cp              & -2.047123\\\\\n",
       "\tSYK-inhibitor\\_\\_SKBR3\\_\\_trt\\_cp & SYK-inhibitor\\_\\_SKBR3\\_\\_trt\\_cp           & -2.655849\\\\\n",
       "\tENMD-2076\\_\\_A375\\_\\_trt\\_cp & ENMD-2076\\_\\_A375\\_\\_trt\\_cp                & -2.061680\\\\\n",
       "\tBRD-K99636700\\_\\_HCC515\\_\\_trt\\_cp & BRD-K99636700\\_\\_HCC515\\_\\_trt\\_cp          & -2.166222\\\\\n",
       "\tapicidin\\_\\_HEPG2\\_\\_trt\\_cp & apicidin\\_\\_HEPG2\\_\\_trt\\_cp                & -2.335700\\\\\n",
       "\tavrainvillamide-analog-4\\_\\_MCF7\\_\\_trt\\_cp & avrainvillamide-analog-4\\_\\_MCF7\\_\\_trt\\_cp & -2.152519\\\\\n",
       "\\end{tabular}\n",
       "\n",
       "\\end{description}\n"
      ],
      "text/markdown": [
       "$VENTX\n",
       ":   \n",
       "A data.frame: 80 × 2\n",
       "\n",
       "| <!--/--> | drug &lt;chr&gt; | zscore &lt;dbl&gt; |\n",
       "|---|---|---|\n",
       "| butoconazole__HCC515__trt_cp | butoconazole__HCC515__trt_cp | -2.043097 |\n",
       "| amcinonide__VCAP__trt_cp | amcinonide__VCAP__trt_cp     | -2.013700 |\n",
       "| verteporfin__VCAP__trt_cp | verteporfin__VCAP__trt_cp    | -2.372383 |\n",
       "| napelline__HT29__trt_cp | napelline__HT29__trt_cp      | -2.024536 |\n",
       "| clioquinol__HT29__trt_cp | clioquinol__HT29__trt_cp     | -2.086267 |\n",
       "| NS-3694__VCAP__trt_cp | NS-3694__VCAP__trt_cp        | -2.178900 |\n",
       "| AS-605240__VCAP__trt_cp | AS-605240__VCAP__trt_cp      | -2.451528 |\n",
       "| SJ-172550__VCAP__trt_cp | SJ-172550__VCAP__trt_cp      | -2.893954 |\n",
       "| JAS07-005__VCAP__trt_cp | JAS07-005__VCAP__trt_cp      | -2.086582 |\n",
       "| BRD-A38425832__MCF7__trt_cp | BRD-A38425832__MCF7__trt_cp  | -2.438600 |\n",
       "| BRD-K32827536__PC3__trt_cp | BRD-K32827536__PC3__trt_cp   | -2.027371 |\n",
       "| BRD-K48844671__PC3__trt_cp | BRD-K48844671__PC3__trt_cp   | -2.115793 |\n",
       "| BRD-K23165181__VCAP__trt_cp | BRD-K23165181__VCAP__trt_cp  | -2.151439 |\n",
       "| BRD-K58247702__VCAP__trt_cp | BRD-K58247702__VCAP__trt_cp  | -2.014121 |\n",
       "| BRD-K70917163__VCAP__trt_cp | BRD-K70917163__VCAP__trt_cp  | -2.195663 |\n",
       "| KU-C104140__A549__trt_cp | KU-C104140__A549__trt_cp     | -2.076100 |\n",
       "| BRD-A11095214__MCF7__trt_cp | BRD-A11095214__MCF7__trt_cp  | -2.200500 |\n",
       "| BRD-K33182644__MCF7__trt_cp | BRD-K33182644__MCF7__trt_cp  | -2.137250 |\n",
       "| BRD-K98991361__A549__trt_cp | BRD-K98991361__A549__trt_cp  | -2.161300 |\n",
       "| oxcarbazepine__MCF7__trt_cp | oxcarbazepine__MCF7__trt_cp  | -2.080350 |\n",
       "| lansoprazole__VCAP__trt_cp | lansoprazole__VCAP__trt_cp   | -2.672177 |\n",
       "| kitasamycin__VCAP__trt_cp | kitasamycin__VCAP__trt_cp    | -2.771939 |\n",
       "| BRD-A16581344__A549__trt_cp | BRD-A16581344__A549__trt_cp  | -2.207200 |\n",
       "| BRD-K88556033__A549__trt_cp | BRD-K88556033__A549__trt_cp  | -2.038800 |\n",
       "| RAN-27__NEU__trt_cp | RAN-27__NEU__trt_cp          | -2.076294 |\n",
       "| BRD-K44893543__NEU__trt_cp | BRD-K44893543__NEU__trt_cp   | -2.608974 |\n",
       "| BRD-K58279162__NEU__trt_cp | BRD-K58279162__NEU__trt_cp   | -2.688838 |\n",
       "| BRD-K14316227__NPC__trt_cp | BRD-K14316227__NPC__trt_cp   | -2.204158 |\n",
       "| treprostinil__PHH__trt_cp | treprostinil__PHH__trt_cp    | -2.756694 |\n",
       "| BRD-K82971429__PHH__trt_cp | BRD-K82971429__PHH__trt_cp   | -2.028831 |\n",
       "| ⋮ | ⋮ | ⋮ |\n",
       "| NSC-663284__PHH__trt_cp | NSC-663284__PHH__trt_cp         | -2.211250 |\n",
       "| zoxazolamine__PHH__trt_cp | zoxazolamine__PHH__trt_cp       | -2.148100 |\n",
       "| nateglinide__PHH__trt_cp | nateglinide__PHH__trt_cp        | -2.026000 |\n",
       "| LFM-A13__NEU__trt_cp | LFM-A13__NEU__trt_cp            | -2.864500 |\n",
       "| BML-257__NEU__trt_cp | BML-257__NEU__trt_cp            | -3.350300 |\n",
       "| lamotrigine__NEU__trt_cp | lamotrigine__NEU__trt_cp        | -2.059334 |\n",
       "| IC-261__PHH__trt_cp | IC-261__PHH__trt_cp             | -2.089171 |\n",
       "| L-701252__PHH__trt_cp | L-701252__PHH__trt_cp           | -3.265500 |\n",
       "| mometasone__PHH__trt_cp | mometasone__PHH__trt_cp         | -2.173689 |\n",
       "| scoulerine__PHH__trt_cp | scoulerine__PHH__trt_cp         | -2.078122 |\n",
       "| dihydroergotamine__PHH__trt_cp | dihydroergotamine__PHH__trt_cp  | -2.580976 |\n",
       "| dipyridamole__PHH__trt_cp | dipyridamole__PHH__trt_cp       | -2.045686 |\n",
       "| tyrphostin-AG-825__MCF7__trt_cp | tyrphostin-AG-825__MCF7__trt_cp | -2.394913 |\n",
       "| rosmarinic-acid__NPC__trt_cp | rosmarinic-acid__NPC__trt_cp    | -2.170692 |\n",
       "| amthamine__PHH__trt_cp | amthamine__PHH__trt_cp          | -2.258550 |\n",
       "| NAN-190__PHH__trt_cp | NAN-190__PHH__trt_cp            | -4.584300 |\n",
       "| BRD-K24053449__MCF7__trt_cp | BRD-K24053449__MCF7__trt_cp     | -2.124968 |\n",
       "| BRD-K88278225__PC3__trt_cp | BRD-K88278225__PC3__trt_cp      | -5.143122 |\n",
       "| BRD-K03358980__VCAP__trt_cp | BRD-K03358980__VCAP__trt_cp     | -2.230576 |\n",
       "| BRD-K06592610__VCAP__trt_cp | BRD-K06592610__VCAP__trt_cp     | -2.063635 |\n",
       "| RDR-01440SC__VCAP__trt_cp | RDR-01440SC__VCAP__trt_cp       | -2.042054 |\n",
       "| BRD-K76691125__VCAP__trt_cp | BRD-K76691125__VCAP__trt_cp     | -2.113669 |\n",
       "| tubacin__VCAP__trt_cp | tubacin__VCAP__trt_cp           | -3.499640 |\n",
       "| BRD-K47512679__NPC__trt_cp | BRD-K47512679__NPC__trt_cp      | -2.032956 |\n",
       "| BRD-K05353139__HT29__trt_cp | BRD-K05353139__HT29__trt_cp     | -2.013206 |\n",
       "| BRD-K48598367__NEU__trt_cp | BRD-K48598367__NEU__trt_cp      | -2.556500 |\n",
       "| SA-419083__NPC__trt_cp | SA-419083__NPC__trt_cp          | -2.028479 |\n",
       "| BRD-K28772322__VCAP__trt_cp | BRD-K28772322__VCAP__trt_cp     | -2.263741 |\n",
       "| nocodazole__FIBRNPC__trt_cp | nocodazole__FIBRNPC__trt_cp     | -2.172350 |\n",
       "| AVA__HA1E__trt_cp | AVA__HA1E__trt_cp               | -2.028199 |\n",
       "\n",
       "\n",
       "$ISL1\n",
       ":   \n",
       "A data.frame: 197 × 2\n",
       "\n",
       "| <!--/--> | drug &lt;chr&gt; | zscore &lt;dbl&gt; |\n",
       "|---|---|---|\n",
       "| BRD-K26684619__CD34__trt_cp | BRD-K26684619__CD34__trt_cp          | -2.040950 |\n",
       "| BRD-A51929314__HA1E__trt_cp | BRD-A51929314__HA1E__trt_cp          | -2.227154 |\n",
       "| MRS-1845__HCC515__trt_cp | MRS-1845__HCC515__trt_cp             | -2.417191 |\n",
       "| melperone__HCC515__trt_cp | melperone__HCC515__trt_cp            | -2.385237 |\n",
       "| FCCP__HCC515__trt_cp | FCCP__HCC515__trt_cp                 | -2.176191 |\n",
       "| BCL2-inhibitor__VCAP__trt_cp | BCL2-inhibitor__VCAP__trt_cp         | -2.520154 |\n",
       "| ubenimex__VCAP__trt_cp | ubenimex__VCAP__trt_cp               | -2.167702 |\n",
       "| epitestosterone__VCAP__trt_cp | epitestosterone__VCAP__trt_cp        | -2.142600 |\n",
       "| procainamide__VCAP__trt_cp | procainamide__VCAP__trt_cp           | -2.136900 |\n",
       "| anagrelide__HA1E__trt_cp | anagrelide__HA1E__trt_cp             | -2.888882 |\n",
       "| bithionol__HCC515__trt_cp | bithionol__HCC515__trt_cp            | -2.335168 |\n",
       "| GW-1929__VCAP__trt_cp | GW-1929__VCAP__trt_cp                | -3.890623 |\n",
       "| CMPD-1__A375__trt_cp | CMPD-1__A375__trt_cp                 | -2.118605 |\n",
       "| ST-638__HA1E__trt_cp | ST-638__HA1E__trt_cp                 | -2.139165 |\n",
       "| fluocinolone-acetonide__HT29__trt_cp | fluocinolone-acetonide__HT29__trt_cp | -2.311850 |\n",
       "| mitoxantrone__HT29__trt_cp | mitoxantrone__HT29__trt_cp           | -2.173384 |\n",
       "| L-168049__VCAP__trt_cp | L-168049__VCAP__trt_cp               | -2.498789 |\n",
       "| BX-795__HT29__trt_cp | BX-795__HT29__trt_cp                 | -2.146887 |\n",
       "| cucurbitacin-i__MCF7__trt_cp | cucurbitacin-i__MCF7__trt_cp         | -2.131572 |\n",
       "| CT-200783__VCAP__trt_cp | CT-200783__VCAP__trt_cp              | -2.346538 |\n",
       "| BRD-K60870698__A375__trt_cp | BRD-K60870698__A375__trt_cp          | -2.611861 |\n",
       "| BRD-K84203638__A375__trt_cp | BRD-K84203638__A375__trt_cp          | -2.241982 |\n",
       "| BRD-K05153001__A549__trt_cp | BRD-K05153001__A549__trt_cp          | -2.140815 |\n",
       "| BRD-K85275009__A549__trt_cp | BRD-K85275009__A549__trt_cp          | -4.711900 |\n",
       "| BRD-K05402890__HA1E__trt_cp | BRD-K05402890__HA1E__trt_cp          | -2.309873 |\n",
       "| BRD-A58924247__HT29__trt_cp | BRD-A58924247__HT29__trt_cp          | -2.229404 |\n",
       "| BRD-K91691979__PC3__trt_cp | BRD-K91691979__PC3__trt_cp           | -2.309459 |\n",
       "| BRD-K19735876__A375__trt_cp | BRD-K19735876__A375__trt_cp          | -2.083350 |\n",
       "| BRD-A21406558__MCF7__trt_cp | BRD-A21406558__MCF7__trt_cp          | -2.156250 |\n",
       "| BRD-K07259155__MCF7__trt_cp | BRD-K07259155__MCF7__trt_cp          | -2.299050 |\n",
       "| ⋮ | ⋮ | ⋮ |\n",
       "| SR-12813__NEU__trt_cp | SR-12813__NEU__trt_cp                | -2.061450 |\n",
       "| LBH-589__NEU__trt_cp | LBH-589__NEU__trt_cp                 | -2.051542 |\n",
       "| BG-1003__NPC__trt_cp | BG-1003__NPC__trt_cp                 | -2.050464 |\n",
       "| LBH-589__NPC__trt_cp | LBH-589__NPC__trt_cp                 | -2.351810 |\n",
       "| BG-1008__NEU__trt_cp | BG-1008__NEU__trt_cp                 | -2.506527 |\n",
       "| temozolomide__NEU__trt_cp | temozolomide__NEU__trt_cp            | -2.358148 |\n",
       "| BG-1005__NEU__trt_cp | BG-1005__NEU__trt_cp                 | -2.408175 |\n",
       "| BG-1025__NEU__trt_cp | BG-1025__NEU__trt_cp                 | -2.330200 |\n",
       "| C2-dihydroceramide__NEU__trt_cp | C2-dihydroceramide__NEU__trt_cp      | -2.060200 |\n",
       "| BG-1030__NEU__trt_cp | BG-1030__NEU__trt_cp                 | -2.047566 |\n",
       "| oxamflatin__NPC__trt_cp | oxamflatin__NPC__trt_cp              | -2.670142 |\n",
       "| BG-1029__NPC__trt_cp | BG-1029__NPC__trt_cp                 | -2.168213 |\n",
       "| BG-1006__NPC__trt_cp | BG-1006__NPC__trt_cp                 | -2.664152 |\n",
       "| BML-284__NPC__trt_cp | BML-284__NPC__trt_cp                 | -4.036828 |\n",
       "| M-344__NPC__trt_cp | M-344__NPC__trt_cp                   | -2.041860 |\n",
       "| BG-1025__NPC__trt_cp | BG-1025__NPC__trt_cp                 | -2.107575 |\n",
       "| BG-1026__NPC__trt_cp | BG-1026__NPC__trt_cp                 | -2.440128 |\n",
       "| NCH-51__NPC__trt_cp | NCH-51__NPC__trt_cp                  | -2.122013 |\n",
       "| BG-1007__NPC__trt_cp | BG-1007__NPC__trt_cp                 | -2.229874 |\n",
       "| BG-1028__NPC__trt_cp | BG-1028__NPC__trt_cp                 | -2.391268 |\n",
       "| BG-1027__NPC__trt_cp | BG-1027__NPC__trt_cp                 | -2.334610 |\n",
       "| tert-butylhydroquinone__MCF7__trt_cp | tert-butylhydroquinone__MCF7__trt_cp | -3.080953 |\n",
       "| panobinostat__A375__trt_cp | panobinostat__A375__trt_cp           | -2.063759 |\n",
       "| staurosporine__A375__trt_cp | staurosporine__A375__trt_cp          | -3.507200 |\n",
       "| apicidin__A375__trt_cp | apicidin__A375__trt_cp               | -2.681550 |\n",
       "| BRD-K57064803__MCF7__trt_cp | BRD-K57064803__MCF7__trt_cp          | -2.356925 |\n",
       "| alpha-tocopherol__MCF7__trt_cp | alpha-tocopherol__MCF7__trt_cp       | -2.502400 |\n",
       "| JMW-MITF1__MCF7__trt_cp | JMW-MITF1__MCF7__trt_cp              | -2.199600 |\n",
       "| alpha-tocopherol__PC3__trt_cp | alpha-tocopherol__PC3__trt_cp        | -2.310900 |\n",
       "| bortezomib__PC3__trt_cp | bortezomib__PC3__trt_cp              | -3.855000 |\n",
       "\n",
       "\n",
       "$HOXC5\n",
       ":   \n",
       "A data.frame: 49 × 2\n",
       "\n",
       "| <!--/--> | drug &lt;chr&gt; | zscore &lt;dbl&gt; |\n",
       "|---|---|---|\n",
       "| aminomethyltransferase__HA1E__trt_cp | aminomethyltransferase__HA1E__trt_cp   | -2.349426 |\n",
       "| ARP-101__HA1E__trt_cp | ARP-101__HA1E__trt_cp                  | -2.420850 |\n",
       "| homoharringtonine__HA1E__trt_cp | homoharringtonine__HA1E__trt_cp        | -2.545411 |\n",
       "| CFM-1571__HCC515__trt_cp | CFM-1571__HCC515__trt_cp               | -2.027797 |\n",
       "| apoptosis-activator-II__HCC515__trt_cp | apoptosis-activator-II__HCC515__trt_cp | -2.027338 |\n",
       "| puromycin__VCAP__trt_cp | puromycin__VCAP__trt_cp                | -3.208967 |\n",
       "| NSC-632839__VCAP__trt_cp | NSC-632839__VCAP__trt_cp               | -2.437900 |\n",
       "| NNC-711__VCAP__trt_cp | NNC-711__VCAP__trt_cp                  | -2.587158 |\n",
       "| MG-132__VCAP__trt_cp | MG-132__VCAP__trt_cp                   | -2.497801 |\n",
       "| Ro-15-4513__VCAP__trt_cp | Ro-15-4513__VCAP__trt_cp               | -2.462467 |\n",
       "| R-59022__HA1E__trt_cp | R-59022__HA1E__trt_cp                  | -2.440392 |\n",
       "| cucurbitacin-i__MCF7__trt_cp | cucurbitacin-i__MCF7__trt_cp           | -2.504937 |\n",
       "| SCH-79797__MCF7__trt_cp | SCH-79797__MCF7__trt_cp                | -3.103155 |\n",
       "| BRD-K19290969__A549__trt_cp | BRD-K19290969__A549__trt_cp            | -2.442208 |\n",
       "| BIX-02188__VCAP__trt_cp | BIX-02188__VCAP__trt_cp                | -2.021193 |\n",
       "| BRD-A98444709__A549__trt_cp | BRD-A98444709__A549__trt_cp            | -2.181950 |\n",
       "| BRD-K18726304__MCF7__trt_cp | BRD-K18726304__MCF7__trt_cp            | -2.498750 |\n",
       "| toremifene__MCF7__trt_cp | toremifene__MCF7__trt_cp               | -2.111762 |\n",
       "| BRD-K32896438__MCF7__trt_cp | BRD-K32896438__MCF7__trt_cp            | -2.568452 |\n",
       "| RAN-27__NEU__trt_cp | RAN-27__NEU__trt_cp                    | -2.057970 |\n",
       "| BRD-K44893543__NEU__trt_cp | BRD-K44893543__NEU__trt_cp             | -2.403568 |\n",
       "| cytochalasin-d__MCF7__trt_cp | cytochalasin-d__MCF7__trt_cp           | -2.524929 |\n",
       "| ST-4029010__NEU__trt_cp | ST-4029010__NEU__trt_cp                | -2.160550 |\n",
       "| sorafenib__VCAP__trt_cp | sorafenib__VCAP__trt_cp                | -2.387828 |\n",
       "| BG-FA-0953__VCAP__trt_cp | BG-FA-0953__VCAP__trt_cp               | -2.010978 |\n",
       "| WYE-354__ASC__trt_cp | WYE-354__ASC__trt_cp                   | -2.030976 |\n",
       "| WYE-125132__MCF7__trt_cp | WYE-125132__MCF7__trt_cp               | -2.019033 |\n",
       "| verrucarin-a__NEU__trt_cp | verrucarin-a__NEU__trt_cp              | -2.535550 |\n",
       "| mirin__VCAP__trt_cp | mirin__VCAP__trt_cp                    | -2.051119 |\n",
       "| CGP-71683__MCF7__trt_cp | CGP-71683__MCF7__trt_cp                | -2.191356 |\n",
       "| NSC-663284__PHH__trt_cp | NSC-663284__PHH__trt_cp                | -2.232050 |\n",
       "| proadifen__ASC__trt_cp | proadifen__ASC__trt_cp                 | -2.171099 |\n",
       "| anisomycin__NEU__trt_cp | anisomycin__NEU__trt_cp                | -2.530992 |\n",
       "| formoterol__SKB__trt_cp | formoterol__SKB__trt_cp                | -2.052984 |\n",
       "| FCCP__MCF7__trt_cp | FCCP__MCF7__trt_cp                     | -2.068842 |\n",
       "| diphenyleneiodonium__MCF7__trt_cp | diphenyleneiodonium__MCF7__trt_cp      | -2.738179 |\n",
       "| NSC-94258__MCF7__trt_cp | NSC-94258__MCF7__trt_cp                | -2.348442 |\n",
       "| SQ-22536__NPC__trt_cp | SQ-22536__NPC__trt_cp                  | -2.024650 |\n",
       "| pyrvinium__MCF7__trt_cp | pyrvinium__MCF7__trt_cp                | -2.287450 |\n",
       "| BRD-K00835201__NEU__trt_cp | BRD-K00835201__NEU__trt_cp             | -2.013800 |\n",
       "| BRD-K75264577__NEU__trt_cp | BRD-K75264577__NEU__trt_cp             | -2.051050 |\n",
       "| BRD-K01477275__NPC__trt_cp | BRD-K01477275__NPC__trt_cp             | -2.038408 |\n",
       "| BRD-K02519835__VCAP__trt_cp | BRD-K02519835__VCAP__trt_cp            | -2.148807 |\n",
       "| motesanib__HS578T__trt_cp | motesanib__HS578T__trt_cp              | -2.047123 |\n",
       "| SYK-inhibitor__SKBR3__trt_cp | SYK-inhibitor__SKBR3__trt_cp           | -2.655849 |\n",
       "| ENMD-2076__A375__trt_cp | ENMD-2076__A375__trt_cp                | -2.061680 |\n",
       "| BRD-K99636700__HCC515__trt_cp | BRD-K99636700__HCC515__trt_cp          | -2.166222 |\n",
       "| apicidin__HEPG2__trt_cp | apicidin__HEPG2__trt_cp                | -2.335700 |\n",
       "| avrainvillamide-analog-4__MCF7__trt_cp | avrainvillamide-analog-4__MCF7__trt_cp | -2.152519 |\n",
       "\n",
       "\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "$VENTX\n",
       "                                                                                       drug\n",
       "butoconazole__HCC515__trt_cp                                   butoconazole__HCC515__trt_cp\n",
       "amcinonide__VCAP__trt_cp                                           amcinonide__VCAP__trt_cp\n",
       "verteporfin__VCAP__trt_cp                                         verteporfin__VCAP__trt_cp\n",
       "napelline__HT29__trt_cp                                             napelline__HT29__trt_cp\n",
       "clioquinol__HT29__trt_cp                                           clioquinol__HT29__trt_cp\n",
       "NS-3694__VCAP__trt_cp                                                 NS-3694__VCAP__trt_cp\n",
       "AS-605240__VCAP__trt_cp                                             AS-605240__VCAP__trt_cp\n",
       "SJ-172550__VCAP__trt_cp                                             SJ-172550__VCAP__trt_cp\n",
       "JAS07-005__VCAP__trt_cp                                             JAS07-005__VCAP__trt_cp\n",
       "BRD-A38425832__MCF7__trt_cp                                     BRD-A38425832__MCF7__trt_cp\n",
       "BRD-K32827536__PC3__trt_cp                                       BRD-K32827536__PC3__trt_cp\n",
       "BRD-K48844671__PC3__trt_cp                                       BRD-K48844671__PC3__trt_cp\n",
       "BRD-K23165181__VCAP__trt_cp                                     BRD-K23165181__VCAP__trt_cp\n",
       "BRD-K58247702__VCAP__trt_cp                                     BRD-K58247702__VCAP__trt_cp\n",
       "BRD-K70917163__VCAP__trt_cp                                     BRD-K70917163__VCAP__trt_cp\n",
       "KU-C104140__A549__trt_cp                                           KU-C104140__A549__trt_cp\n",
       "BRD-A11095214__MCF7__trt_cp                                     BRD-A11095214__MCF7__trt_cp\n",
       "BRD-K33182644__MCF7__trt_cp                                     BRD-K33182644__MCF7__trt_cp\n",
       "BRD-K98991361__A549__trt_cp                                     BRD-K98991361__A549__trt_cp\n",
       "oxcarbazepine__MCF7__trt_cp                                     oxcarbazepine__MCF7__trt_cp\n",
       "lansoprazole__VCAP__trt_cp                                       lansoprazole__VCAP__trt_cp\n",
       "kitasamycin__VCAP__trt_cp                                         kitasamycin__VCAP__trt_cp\n",
       "BRD-A16581344__A549__trt_cp                                     BRD-A16581344__A549__trt_cp\n",
       "BRD-K88556033__A549__trt_cp                                     BRD-K88556033__A549__trt_cp\n",
       "RAN-27__NEU__trt_cp                                                     RAN-27__NEU__trt_cp\n",
       "BRD-K44893543__NEU__trt_cp                                       BRD-K44893543__NEU__trt_cp\n",
       "BRD-K58279162__NEU__trt_cp                                       BRD-K58279162__NEU__trt_cp\n",
       "BRD-K14316227__NPC__trt_cp                                       BRD-K14316227__NPC__trt_cp\n",
       "treprostinil__PHH__trt_cp                                         treprostinil__PHH__trt_cp\n",
       "BRD-K82971429__PHH__trt_cp                                       BRD-K82971429__PHH__trt_cp\n",
       "BRD-K21672423__SKB__trt_cp                                       BRD-K21672423__SKB__trt_cp\n",
       "BRD-K35568648__SKB__trt_cp                                       BRD-K35568648__SKB__trt_cp\n",
       "BRD-K98731749__VCAP__trt_cp                                     BRD-K98731749__VCAP__trt_cp\n",
       "BRD-K54159704__NEU__trt_cp                                       BRD-K54159704__NEU__trt_cp\n",
       "BRD-A60386802__NPC__trt_cp                                       BRD-A60386802__NPC__trt_cp\n",
       "BRD-K09460252__SKB__trt_cp                                       BRD-K09460252__SKB__trt_cp\n",
       "BRD-A30083233__VCAP__trt_cp                                     BRD-A30083233__VCAP__trt_cp\n",
       "BRD-A68274214__VCAP__trt_cp                                     BRD-A68274214__VCAP__trt_cp\n",
       "BRD-K16180117__VCAP__trt_cp                                     BRD-K16180117__VCAP__trt_cp\n",
       "parthenolide-(alternate-stereo)__VCAP__trt_cp parthenolide-(alternate-stereo)__VCAP__trt_cp\n",
       "BRD-K47764688__VCAP__trt_cp                                     BRD-K47764688__VCAP__trt_cp\n",
       "BRD-K52914903__VCAP__trt_cp                                     BRD-K52914903__VCAP__trt_cp\n",
       "SEW-05685__VCAP__trt_cp                                             SEW-05685__VCAP__trt_cp\n",
       "BRD-K88542532__VCAP__trt_cp                                     BRD-K88542532__VCAP__trt_cp\n",
       "BRD-A77577770__A549__trt_cp                                     BRD-A77577770__A549__trt_cp\n",
       "EMF-BCA1-57__ASC__trt_cp                                           EMF-BCA1-57__ASC__trt_cp\n",
       "acitretin__NEU__trt_cp                                               acitretin__NEU__trt_cp\n",
       "mitotane__A549__trt_cp                                               mitotane__A549__trt_cp\n",
       "aminopentamide__A549__trt_cp                                   aminopentamide__A549__trt_cp\n",
       "probenecid__A549__trt_cp                                           probenecid__A549__trt_cp\n",
       "NSC-663284__PHH__trt_cp                                             NSC-663284__PHH__trt_cp\n",
       "zoxazolamine__PHH__trt_cp                                         zoxazolamine__PHH__trt_cp\n",
       "nateglinide__PHH__trt_cp                                           nateglinide__PHH__trt_cp\n",
       "LFM-A13__NEU__trt_cp                                                   LFM-A13__NEU__trt_cp\n",
       "BML-257__NEU__trt_cp                                                   BML-257__NEU__trt_cp\n",
       "lamotrigine__NEU__trt_cp                                           lamotrigine__NEU__trt_cp\n",
       "IC-261__PHH__trt_cp                                                     IC-261__PHH__trt_cp\n",
       "L-701252__PHH__trt_cp                                                 L-701252__PHH__trt_cp\n",
       "mometasone__PHH__trt_cp                                             mometasone__PHH__trt_cp\n",
       "scoulerine__PHH__trt_cp                                             scoulerine__PHH__trt_cp\n",
       "dihydroergotamine__PHH__trt_cp                               dihydroergotamine__PHH__trt_cp\n",
       "dipyridamole__PHH__trt_cp                                         dipyridamole__PHH__trt_cp\n",
       "tyrphostin-AG-825__MCF7__trt_cp                             tyrphostin-AG-825__MCF7__trt_cp\n",
       "rosmarinic-acid__NPC__trt_cp                                   rosmarinic-acid__NPC__trt_cp\n",
       "amthamine__PHH__trt_cp                                               amthamine__PHH__trt_cp\n",
       "NAN-190__PHH__trt_cp                                                   NAN-190__PHH__trt_cp\n",
       "BRD-K24053449__MCF7__trt_cp                                     BRD-K24053449__MCF7__trt_cp\n",
       "BRD-K88278225__PC3__trt_cp                                       BRD-K88278225__PC3__trt_cp\n",
       "BRD-K03358980__VCAP__trt_cp                                     BRD-K03358980__VCAP__trt_cp\n",
       "BRD-K06592610__VCAP__trt_cp                                     BRD-K06592610__VCAP__trt_cp\n",
       "RDR-01440SC__VCAP__trt_cp                                         RDR-01440SC__VCAP__trt_cp\n",
       "BRD-K76691125__VCAP__trt_cp                                     BRD-K76691125__VCAP__trt_cp\n",
       "tubacin__VCAP__trt_cp                                                 tubacin__VCAP__trt_cp\n",
       "BRD-K47512679__NPC__trt_cp                                       BRD-K47512679__NPC__trt_cp\n",
       "BRD-K05353139__HT29__trt_cp                                     BRD-K05353139__HT29__trt_cp\n",
       "BRD-K48598367__NEU__trt_cp                                       BRD-K48598367__NEU__trt_cp\n",
       "SA-419083__NPC__trt_cp                                               SA-419083__NPC__trt_cp\n",
       "BRD-K28772322__VCAP__trt_cp                                     BRD-K28772322__VCAP__trt_cp\n",
       "nocodazole__FIBRNPC__trt_cp                                     nocodazole__FIBRNPC__trt_cp\n",
       "AVA__HA1E__trt_cp                                                         AVA__HA1E__trt_cp\n",
       "                                                 zscore\n",
       "butoconazole__HCC515__trt_cp                  -2.043097\n",
       "amcinonide__VCAP__trt_cp                      -2.013700\n",
       "verteporfin__VCAP__trt_cp                     -2.372383\n",
       "napelline__HT29__trt_cp                       -2.024536\n",
       "clioquinol__HT29__trt_cp                      -2.086267\n",
       "NS-3694__VCAP__trt_cp                         -2.178900\n",
       "AS-605240__VCAP__trt_cp                       -2.451528\n",
       "SJ-172550__VCAP__trt_cp                       -2.893954\n",
       "JAS07-005__VCAP__trt_cp                       -2.086582\n",
       "BRD-A38425832__MCF7__trt_cp                   -2.438600\n",
       "BRD-K32827536__PC3__trt_cp                    -2.027371\n",
       "BRD-K48844671__PC3__trt_cp                    -2.115793\n",
       "BRD-K23165181__VCAP__trt_cp                   -2.151439\n",
       "BRD-K58247702__VCAP__trt_cp                   -2.014121\n",
       "BRD-K70917163__VCAP__trt_cp                   -2.195663\n",
       "KU-C104140__A549__trt_cp                      -2.076100\n",
       "BRD-A11095214__MCF7__trt_cp                   -2.200500\n",
       "BRD-K33182644__MCF7__trt_cp                   -2.137250\n",
       "BRD-K98991361__A549__trt_cp                   -2.161300\n",
       "oxcarbazepine__MCF7__trt_cp                   -2.080350\n",
       "lansoprazole__VCAP__trt_cp                    -2.672177\n",
       "kitasamycin__VCAP__trt_cp                     -2.771939\n",
       "BRD-A16581344__A549__trt_cp                   -2.207200\n",
       "BRD-K88556033__A549__trt_cp                   -2.038800\n",
       "RAN-27__NEU__trt_cp                           -2.076294\n",
       "BRD-K44893543__NEU__trt_cp                    -2.608974\n",
       "BRD-K58279162__NEU__trt_cp                    -2.688838\n",
       "BRD-K14316227__NPC__trt_cp                    -2.204158\n",
       "treprostinil__PHH__trt_cp                     -2.756694\n",
       "BRD-K82971429__PHH__trt_cp                    -2.028831\n",
       "BRD-K21672423__SKB__trt_cp                    -2.009029\n",
       "BRD-K35568648__SKB__trt_cp                    -2.132345\n",
       "BRD-K98731749__VCAP__trt_cp                   -2.255098\n",
       "BRD-K54159704__NEU__trt_cp                    -2.431950\n",
       "BRD-A60386802__NPC__trt_cp                    -2.105715\n",
       "BRD-K09460252__SKB__trt_cp                    -2.230373\n",
       "BRD-A30083233__VCAP__trt_cp                   -3.686601\n",
       "BRD-A68274214__VCAP__trt_cp                   -2.685372\n",
       "BRD-K16180117__VCAP__trt_cp                   -3.084749\n",
       "parthenolide-(alternate-stereo)__VCAP__trt_cp -2.591435\n",
       "BRD-K47764688__VCAP__trt_cp                   -2.465660\n",
       "BRD-K52914903__VCAP__trt_cp                   -2.128565\n",
       "SEW-05685__VCAP__trt_cp                       -2.412868\n",
       "BRD-K88542532__VCAP__trt_cp                   -2.193973\n",
       "BRD-A77577770__A549__trt_cp                   -2.333757\n",
       "EMF-BCA1-57__ASC__trt_cp                      -2.248311\n",
       "acitretin__NEU__trt_cp                        -2.018050\n",
       "mitotane__A549__trt_cp                        -2.225927\n",
       "aminopentamide__A549__trt_cp                  -2.421756\n",
       "probenecid__A549__trt_cp                      -2.769047\n",
       "NSC-663284__PHH__trt_cp                       -2.211250\n",
       "zoxazolamine__PHH__trt_cp                     -2.148100\n",
       "nateglinide__PHH__trt_cp                      -2.026000\n",
       "LFM-A13__NEU__trt_cp                          -2.864500\n",
       "BML-257__NEU__trt_cp                          -3.350300\n",
       "lamotrigine__NEU__trt_cp                      -2.059334\n",
       "IC-261__PHH__trt_cp                           -2.089171\n",
       "L-701252__PHH__trt_cp                         -3.265500\n",
       "mometasone__PHH__trt_cp                       -2.173689\n",
       "scoulerine__PHH__trt_cp                       -2.078122\n",
       "dihydroergotamine__PHH__trt_cp                -2.580976\n",
       "dipyridamole__PHH__trt_cp                     -2.045686\n",
       "tyrphostin-AG-825__MCF7__trt_cp               -2.394913\n",
       "rosmarinic-acid__NPC__trt_cp                  -2.170692\n",
       "amthamine__PHH__trt_cp                        -2.258550\n",
       "NAN-190__PHH__trt_cp                          -4.584300\n",
       "BRD-K24053449__MCF7__trt_cp                   -2.124968\n",
       "BRD-K88278225__PC3__trt_cp                    -5.143122\n",
       "BRD-K03358980__VCAP__trt_cp                   -2.230576\n",
       "BRD-K06592610__VCAP__trt_cp                   -2.063635\n",
       "RDR-01440SC__VCAP__trt_cp                     -2.042054\n",
       "BRD-K76691125__VCAP__trt_cp                   -2.113669\n",
       "tubacin__VCAP__trt_cp                         -3.499640\n",
       "BRD-K47512679__NPC__trt_cp                    -2.032956\n",
       "BRD-K05353139__HT29__trt_cp                   -2.013206\n",
       "BRD-K48598367__NEU__trt_cp                    -2.556500\n",
       "SA-419083__NPC__trt_cp                        -2.028479\n",
       "BRD-K28772322__VCAP__trt_cp                   -2.263741\n",
       "nocodazole__FIBRNPC__trt_cp                   -2.172350\n",
       "AVA__HA1E__trt_cp                             -2.028199\n",
       "\n",
       "$ISL1\n",
       "                                                                                       drug\n",
       "BRD-K26684619__CD34__trt_cp                                     BRD-K26684619__CD34__trt_cp\n",
       "BRD-A51929314__HA1E__trt_cp                                     BRD-A51929314__HA1E__trt_cp\n",
       "MRS-1845__HCC515__trt_cp                                           MRS-1845__HCC515__trt_cp\n",
       "melperone__HCC515__trt_cp                                         melperone__HCC515__trt_cp\n",
       "FCCP__HCC515__trt_cp                                                   FCCP__HCC515__trt_cp\n",
       "BCL2-inhibitor__VCAP__trt_cp                                   BCL2-inhibitor__VCAP__trt_cp\n",
       "ubenimex__VCAP__trt_cp                                               ubenimex__VCAP__trt_cp\n",
       "epitestosterone__VCAP__trt_cp                                 epitestosterone__VCAP__trt_cp\n",
       "procainamide__VCAP__trt_cp                                       procainamide__VCAP__trt_cp\n",
       "anagrelide__HA1E__trt_cp                                           anagrelide__HA1E__trt_cp\n",
       "bithionol__HCC515__trt_cp                                         bithionol__HCC515__trt_cp\n",
       "GW-1929__VCAP__trt_cp                                                 GW-1929__VCAP__trt_cp\n",
       "CMPD-1__A375__trt_cp                                                   CMPD-1__A375__trt_cp\n",
       "ST-638__HA1E__trt_cp                                                   ST-638__HA1E__trt_cp\n",
       "fluocinolone-acetonide__HT29__trt_cp                   fluocinolone-acetonide__HT29__trt_cp\n",
       "mitoxantrone__HT29__trt_cp                                       mitoxantrone__HT29__trt_cp\n",
       "L-168049__VCAP__trt_cp                                               L-168049__VCAP__trt_cp\n",
       "BX-795__HT29__trt_cp                                                   BX-795__HT29__trt_cp\n",
       "cucurbitacin-i__MCF7__trt_cp                                   cucurbitacin-i__MCF7__trt_cp\n",
       "CT-200783__VCAP__trt_cp                                             CT-200783__VCAP__trt_cp\n",
       "BRD-K60870698__A375__trt_cp                                     BRD-K60870698__A375__trt_cp\n",
       "BRD-K84203638__A375__trt_cp                                     BRD-K84203638__A375__trt_cp\n",
       "BRD-K05153001__A549__trt_cp                                     BRD-K05153001__A549__trt_cp\n",
       "BRD-K85275009__A549__trt_cp                                     BRD-K85275009__A549__trt_cp\n",
       "BRD-K05402890__HA1E__trt_cp                                     BRD-K05402890__HA1E__trt_cp\n",
       "BRD-A58924247__HT29__trt_cp                                     BRD-A58924247__HT29__trt_cp\n",
       "BRD-K91691979__PC3__trt_cp                                       BRD-K91691979__PC3__trt_cp\n",
       "BRD-K19735876__A375__trt_cp                                     BRD-K19735876__A375__trt_cp\n",
       "BRD-A21406558__MCF7__trt_cp                                     BRD-A21406558__MCF7__trt_cp\n",
       "BRD-K07259155__MCF7__trt_cp                                     BRD-K07259155__MCF7__trt_cp\n",
       "BRD-K66884694__MCF7__trt_cp                                     BRD-K66884694__MCF7__trt_cp\n",
       "BRD-K44366801__VCAP__trt_cp                                     BRD-K44366801__VCAP__trt_cp\n",
       "BRD-K66884694__VCAP__trt_cp                                     BRD-K66884694__VCAP__trt_cp\n",
       "BRD-K97936712__VCAP__trt_cp                                     BRD-K97936712__VCAP__trt_cp\n",
       "BRD-K43267173__A549__trt_cp                                     BRD-K43267173__A549__trt_cp\n",
       "BRD-K36354764__MCF7__trt_cp                                     BRD-K36354764__MCF7__trt_cp\n",
       "BRD-K69516039__MCF7__trt_cp                                     BRD-K69516039__MCF7__trt_cp\n",
       "BRD-K89224880__VCAP__trt_cp                                     BRD-K89224880__VCAP__trt_cp\n",
       "BRD-K31600199__A549__trt_cp                                     BRD-K31600199__A549__trt_cp\n",
       "BRD-K96213252__PC3__trt_cp                                       BRD-K96213252__PC3__trt_cp\n",
       "BRD-K01265221__VCAP__trt_cp                                     BRD-K01265221__VCAP__trt_cp\n",
       "BRD-K49403449__VCAP__trt_cp                                     BRD-K49403449__VCAP__trt_cp\n",
       "doxylamine__MCF7__trt_cp                                           doxylamine__MCF7__trt_cp\n",
       "BRD-K02223034__A549__trt_cp                                     BRD-K02223034__A549__trt_cp\n",
       "BRD-K25731886__A549__trt_cp                                     BRD-K25731886__A549__trt_cp\n",
       "alvocidib__A549__trt_cp                                             alvocidib__A549__trt_cp\n",
       "BRD-K04534322__NEU__trt_cp                                       BRD-K04534322__NEU__trt_cp\n",
       "doxercalciferol__NEU__trt_cp                                   doxercalciferol__NEU__trt_cp\n",
       "BRD-K25731886__NEU__trt_cp                                       BRD-K25731886__NEU__trt_cp\n",
       "fludarabine__NEU__trt_cp                                           fludarabine__NEU__trt_cp\n",
       "vorinostat__NEU__trt_cp                                             vorinostat__NEU__trt_cp\n",
       "BRD-K98731749__NEU__trt_cp                                       BRD-K98731749__NEU__trt_cp\n",
       "HU-211__NPC__trt_cp                                                     HU-211__NPC__trt_cp\n",
       "panobinostat__NPC__trt_cp                                         panobinostat__NPC__trt_cp\n",
       "MD-II-038__NPC__trt_cp                                               MD-II-038__NPC__trt_cp\n",
       "vorinostat__NPC__trt_cp                                             vorinostat__NPC__trt_cp\n",
       "BRD-K36767861__PHH__trt_cp                                       BRD-K36767861__PHH__trt_cp\n",
       "BRD-K76926998__PHH__trt_cp                                       BRD-K76926998__PHH__trt_cp\n",
       "BRD-K02223034__SKB__trt_cp                                       BRD-K02223034__SKB__trt_cp\n",
       "SA-1447005__VCAP__trt_cp                                           SA-1447005__VCAP__trt_cp\n",
       "KM-01366__A549__trt_cp                                               KM-01366__A549__trt_cp\n",
       "cilomilast__A549__trt_cp                                           cilomilast__A549__trt_cp\n",
       "STOCK1S-03920__MCF7__trt_cp                                     STOCK1S-03920__MCF7__trt_cp\n",
       "BRD-A68274214__NEU__trt_cp                                       BRD-A68274214__NEU__trt_cp\n",
       "F-1061-0166__NEU__trt_cp                                           F-1061-0166__NEU__trt_cp\n",
       "danusertib__NEU__trt_cp                                             danusertib__NEU__trt_cp\n",
       "daunorubicin__NEU__trt_cp                                         daunorubicin__NEU__trt_cp\n",
       "BRD-K03176945__NPC__trt_cp                                       BRD-K03176945__NPC__trt_cp\n",
       "daunorubicin__NPC__trt_cp                                         daunorubicin__NPC__trt_cp\n",
       "YM-155__NPC__trt_cp                                                     YM-155__NPC__trt_cp\n",
       "BRD-K18163752__VCAP__trt_cp                                     BRD-K18163752__VCAP__trt_cp\n",
       "parthenolide-(alternate-stereo)__VCAP__trt_cp parthenolide-(alternate-stereo)__VCAP__trt_cp\n",
       "fenretinide__A549__trt_cp                                         fenretinide__A549__trt_cp\n",
       "EI-231__NEU__trt_cp                                                     EI-231__NEU__trt_cp\n",
       "STK-397047__NEU__trt_cp                                             STK-397047__NEU__trt_cp\n",
       "HO-013__NEU__trt_cp                                                     HO-013__NEU__trt_cp\n",
       "SB-590885__NPC__trt_cp                                               SB-590885__NPC__trt_cp\n",
       "A-443644__NPC__trt_cp                                                 A-443644__NPC__trt_cp\n",
       "crizotinib__NPC__trt_cp                                             crizotinib__NPC__trt_cp\n",
       "SB-239063__NPC__trt_cp                                               SB-239063__NPC__trt_cp\n",
       "fenretinide__NPC__trt_cp                                           fenretinide__NPC__trt_cp\n",
       "WZ-3105__NPC__trt_cp                                                   WZ-3105__NPC__trt_cp\n",
       "torin-2__PHH__trt_cp                                                   torin-2__PHH__trt_cp\n",
       "linifanib__PHH__trt_cp                                               linifanib__PHH__trt_cp\n",
       "BRD-K07061353__VCAP__trt_cp                                     BRD-K07061353__VCAP__trt_cp\n",
       "mitotane__A549__trt_cp                                               mitotane__A549__trt_cp\n",
       "nocodazole__NPC__trt_cp                                             nocodazole__NPC__trt_cp\n",
       "penfluridol__NPC__trt_cp                                           penfluridol__NPC__trt_cp\n",
       "podophyllotoxin__NPC__trt_cp                                   podophyllotoxin__NPC__trt_cp\n",
       "butoconazole__PHH__trt_cp                                         butoconazole__PHH__trt_cp\n",
       "vinblastine__PHH__trt_cp                                           vinblastine__PHH__trt_cp\n",
       "paroxetine__PHH__trt_cp                                             paroxetine__PHH__trt_cp\n",
       "dicyclohexylurea__SKB__trt_cp                                 dicyclohexylurea__SKB__trt_cp\n",
       "anisomycin__ASC__trt_cp                                             anisomycin__ASC__trt_cp\n",
       "LFM-A13__NEU__trt_cp                                                   LFM-A13__NEU__trt_cp\n",
       "bisindolylmaleimide-ix__NEU__trt_cp                     bisindolylmaleimide-ix__NEU__trt_cp\n",
       "BML-257__NEU__trt_cp                                                   BML-257__NEU__trt_cp\n",
       "caffeic-acid__NEU__trt_cp                                         caffeic-acid__NEU__trt_cp\n",
       "BRD-K93541117__NEU__trt_cp                                       BRD-K93541117__NEU__trt_cp\n",
       "teniposide__NPC__trt_cp                                             teniposide__NPC__trt_cp\n",
       "aminopurvalanol-a__NPC__trt_cp                               aminopurvalanol-a__NPC__trt_cp\n",
       "dextromethorphan__NPC__trt_cp                                 dextromethorphan__NPC__trt_cp\n",
       "LY-2183240__NPC__trt_cp                                             LY-2183240__NPC__trt_cp\n",
       "methyl-2,5-dihydroxycinnamate__NPC__trt_cp       methyl-2,5-dihydroxycinnamate__NPC__trt_cp\n",
       "mocimycin__A549__trt_cp                                             mocimycin__A549__trt_cp\n",
       "calycanthine__A549__trt_cp                                       calycanthine__A549__trt_cp\n",
       "L-701252__ASC__trt_cp                                                 L-701252__ASC__trt_cp\n",
       "BMY-14802__NPC__trt_cp                                               BMY-14802__NPC__trt_cp\n",
       "KF-38789__NPC__trt_cp                                                 KF-38789__NPC__trt_cp\n",
       "ryuvidine__NPC__trt_cp                                               ryuvidine__NPC__trt_cp\n",
       "ER-27319__NPC__trt_cp                                                 ER-27319__NPC__trt_cp\n",
       "SYK-inhibitor__NPC__trt_cp                                       SYK-inhibitor__NPC__trt_cp\n",
       "SB-431542__NPC__trt_cp                                               SB-431542__NPC__trt_cp\n",
       "BMY-14802__PHH__trt_cp                                               BMY-14802__PHH__trt_cp\n",
       "ER-27319__PHH__trt_cp                                                 ER-27319__PHH__trt_cp\n",
       "milrinone__PHH__trt_cp                                               milrinone__PHH__trt_cp\n",
       "CS-110266__ASC__trt_cp                                               CS-110266__ASC__trt_cp\n",
       "gitoxigenin__NPC__trt_cp                                           gitoxigenin__NPC__trt_cp\n",
       "cymarin__NPC__trt_cp                                                   cymarin__NPC__trt_cp\n",
       "amiodarone__PHH__trt_cp                                             amiodarone__PHH__trt_cp\n",
       "tranilast__PHH__trt_cp                                               tranilast__PHH__trt_cp\n",
       "DMeOB__PHH__trt_cp                                                       DMeOB__PHH__trt_cp\n",
       "DCEBIO__PHH__trt_cp                                                     DCEBIO__PHH__trt_cp\n",
       "hexamethyleneamiloride__PHH__trt_cp                     hexamethyleneamiloride__PHH__trt_cp\n",
       "EMF-bca1-16__VCAP__trt_cp                                         EMF-bca1-16__VCAP__trt_cp\n",
       "LY-2140023__VCAP__trt_cp                                           LY-2140023__VCAP__trt_cp\n",
       "aminohippuric-acid__PC3__trt_cp                             aminohippuric-acid__PC3__trt_cp\n",
       "triphenyl-tin__HA1E__trt_cp                                     triphenyl-tin__HA1E__trt_cp\n",
       "tributyltin__HA1E__trt_cp                                         tributyltin__HA1E__trt_cp\n",
       "BRD-K86671899__A375__trt_cp                                     BRD-K86671899__A375__trt_cp\n",
       "BRD-K23985857__HT29__trt_cp                                     BRD-K23985857__HT29__trt_cp\n",
       "BRD-K62242359__HT29__trt_cp                                     BRD-K62242359__HT29__trt_cp\n",
       "BRD-K90734091__HT29__trt_cp                                     BRD-K90734091__HT29__trt_cp\n",
       "BRD-K00381581__NEU__trt_cp                                       BRD-K00381581__NEU__trt_cp\n",
       "BRD-K38294617__NEU__trt_cp                                       BRD-K38294617__NEU__trt_cp\n",
       "BRD-K48673964__NEU__trt_cp                                       BRD-K48673964__NEU__trt_cp\n",
       "BRD-K88822846__NEU__trt_cp                                       BRD-K88822846__NEU__trt_cp\n",
       "BRD-K86048057__NPC__trt_cp                                       BRD-K86048057__NPC__trt_cp\n",
       "BRD-K29423519__A549__trt_cp                                     BRD-K29423519__A549__trt_cp\n",
       "BRD-K73276569__A549__trt_cp                                     BRD-K73276569__A549__trt_cp\n",
       "BRD-K15524596__NEU__trt_cp                                       BRD-K15524596__NEU__trt_cp\n",
       "BRD-K79532217__NEU__trt_cp                                       BRD-K79532217__NEU__trt_cp\n",
       "BRD-K68504618__NPC__trt_cp                                       BRD-K68504618__NPC__trt_cp\n",
       "BRD-K80169513__NPC__trt_cp                                       BRD-K80169513__NPC__trt_cp\n",
       "BRD-K81408913__NPC__trt_cp                                       BRD-K81408913__NPC__trt_cp\n",
       "BRD-K85205404__NPC__trt_cp                                       BRD-K85205404__NPC__trt_cp\n",
       "BRD-K36620425__VCAP__trt_cp                                     BRD-K36620425__VCAP__trt_cp\n",
       "BRD-K18545493__VCAP__trt_cp                                     BRD-K18545493__VCAP__trt_cp\n",
       "BRD-K97255584__VCAP__trt_cp                                     BRD-K97255584__VCAP__trt_cp\n",
       "peruvoside__VCAP__trt_cp                                           peruvoside__VCAP__trt_cp\n",
       "lanatoside-c__VCAP__trt_cp                                       lanatoside-c__VCAP__trt_cp\n",
       "BRD-K34314104__VCAP__trt_cp                                     BRD-K34314104__VCAP__trt_cp\n",
       "BRD-K26510616__PC3__trt_cp                                       BRD-K26510616__PC3__trt_cp\n",
       "QL-X-138__MCF10A__trt_cp                                           QL-X-138__MCF10A__trt_cp\n",
       "PD-0325901__BT20__trt_cp                                           PD-0325901__BT20__trt_cp\n",
       "ON-01910__BT20__trt_cp                                               ON-01910__BT20__trt_cp\n",
       "SA-1925610__MCF7__trt_cp                                           SA-1925610__MCF7__trt_cp\n",
       "SA-3676__NKDBA__trt_cp                                               SA-3676__NKDBA__trt_cp\n",
       "SA-1459213__MCF7__trt_cp                                           SA-1459213__MCF7__trt_cp\n",
       "BRD-A12426960__FIBRNPC__trt_cp                               BRD-A12426960__FIBRNPC__trt_cp\n",
       "ephedrine__FIBRNPC__trt_cp                                       ephedrine__FIBRNPC__trt_cp\n",
       "6-nitrodopamine__FIBRNPC__trt_cp                           6-nitrodopamine__FIBRNPC__trt_cp\n",
       "BRD-K19653414__FIBRNPC__trt_cp                               BRD-K19653414__FIBRNPC__trt_cp\n",
       "n-bromoacetyltryptamine__FIBRNPC__trt_cp           n-bromoacetyltryptamine__FIBRNPC__trt_cp\n",
       "BRD-A42610307__NEU__trt_cp                                       BRD-A42610307__NEU__trt_cp\n",
       "BRD-A86146706__NEU__trt_cp                                       BRD-A86146706__NEU__trt_cp\n",
       "BG-1003__NEU__trt_cp                                                   BG-1003__NEU__trt_cp\n",
       "SR-12813__NEU__trt_cp                                                 SR-12813__NEU__trt_cp\n",
       "LBH-589__NEU__trt_cp                                                   LBH-589__NEU__trt_cp\n",
       "BG-1003__NPC__trt_cp                                                   BG-1003__NPC__trt_cp\n",
       "LBH-589__NPC__trt_cp                                                   LBH-589__NPC__trt_cp\n",
       "BG-1008__NEU__trt_cp                                                   BG-1008__NEU__trt_cp\n",
       "temozolomide__NEU__trt_cp                                         temozolomide__NEU__trt_cp\n",
       "BG-1005__NEU__trt_cp                                                   BG-1005__NEU__trt_cp\n",
       "BG-1025__NEU__trt_cp                                                   BG-1025__NEU__trt_cp\n",
       "C2-dihydroceramide__NEU__trt_cp                             C2-dihydroceramide__NEU__trt_cp\n",
       "BG-1030__NEU__trt_cp                                                   BG-1030__NEU__trt_cp\n",
       "oxamflatin__NPC__trt_cp                                             oxamflatin__NPC__trt_cp\n",
       "BG-1029__NPC__trt_cp                                                   BG-1029__NPC__trt_cp\n",
       "BG-1006__NPC__trt_cp                                                   BG-1006__NPC__trt_cp\n",
       "BML-284__NPC__trt_cp                                                   BML-284__NPC__trt_cp\n",
       "M-344__NPC__trt_cp                                                       M-344__NPC__trt_cp\n",
       "BG-1025__NPC__trt_cp                                                   BG-1025__NPC__trt_cp\n",
       "BG-1026__NPC__trt_cp                                                   BG-1026__NPC__trt_cp\n",
       "NCH-51__NPC__trt_cp                                                     NCH-51__NPC__trt_cp\n",
       "BG-1007__NPC__trt_cp                                                   BG-1007__NPC__trt_cp\n",
       "BG-1028__NPC__trt_cp                                                   BG-1028__NPC__trt_cp\n",
       "BG-1027__NPC__trt_cp                                                   BG-1027__NPC__trt_cp\n",
       "tert-butylhydroquinone__MCF7__trt_cp                   tert-butylhydroquinone__MCF7__trt_cp\n",
       "panobinostat__A375__trt_cp                                       panobinostat__A375__trt_cp\n",
       "staurosporine__A375__trt_cp                                     staurosporine__A375__trt_cp\n",
       "apicidin__A375__trt_cp                                               apicidin__A375__trt_cp\n",
       "BRD-K57064803__MCF7__trt_cp                                     BRD-K57064803__MCF7__trt_cp\n",
       "alpha-tocopherol__MCF7__trt_cp                               alpha-tocopherol__MCF7__trt_cp\n",
       "JMW-MITF1__MCF7__trt_cp                                             JMW-MITF1__MCF7__trt_cp\n",
       "alpha-tocopherol__PC3__trt_cp                                 alpha-tocopherol__PC3__trt_cp\n",
       "bortezomib__PC3__trt_cp                                             bortezomib__PC3__trt_cp\n",
       "                                                 zscore\n",
       "BRD-K26684619__CD34__trt_cp                   -2.040950\n",
       "BRD-A51929314__HA1E__trt_cp                   -2.227154\n",
       "MRS-1845__HCC515__trt_cp                      -2.417191\n",
       "melperone__HCC515__trt_cp                     -2.385237\n",
       "FCCP__HCC515__trt_cp                          -2.176191\n",
       "BCL2-inhibitor__VCAP__trt_cp                  -2.520154\n",
       "ubenimex__VCAP__trt_cp                        -2.167702\n",
       "epitestosterone__VCAP__trt_cp                 -2.142600\n",
       "procainamide__VCAP__trt_cp                    -2.136900\n",
       "anagrelide__HA1E__trt_cp                      -2.888882\n",
       "bithionol__HCC515__trt_cp                     -2.335168\n",
       "GW-1929__VCAP__trt_cp                         -3.890623\n",
       "CMPD-1__A375__trt_cp                          -2.118605\n",
       "ST-638__HA1E__trt_cp                          -2.139165\n",
       "fluocinolone-acetonide__HT29__trt_cp          -2.311850\n",
       "mitoxantrone__HT29__trt_cp                    -2.173384\n",
       "L-168049__VCAP__trt_cp                        -2.498789\n",
       "BX-795__HT29__trt_cp                          -2.146887\n",
       "cucurbitacin-i__MCF7__trt_cp                  -2.131572\n",
       "CT-200783__VCAP__trt_cp                       -2.346538\n",
       "BRD-K60870698__A375__trt_cp                   -2.611861\n",
       "BRD-K84203638__A375__trt_cp                   -2.241982\n",
       "BRD-K05153001__A549__trt_cp                   -2.140815\n",
       "BRD-K85275009__A549__trt_cp                   -4.711900\n",
       "BRD-K05402890__HA1E__trt_cp                   -2.309873\n",
       "BRD-A58924247__HT29__trt_cp                   -2.229404\n",
       "BRD-K91691979__PC3__trt_cp                    -2.309459\n",
       "BRD-K19735876__A375__trt_cp                   -2.083350\n",
       "BRD-A21406558__MCF7__trt_cp                   -2.156250\n",
       "BRD-K07259155__MCF7__trt_cp                   -2.299050\n",
       "BRD-K66884694__MCF7__trt_cp                   -2.475050\n",
       "BRD-K44366801__VCAP__trt_cp                   -2.178808\n",
       "BRD-K66884694__VCAP__trt_cp                   -2.011937\n",
       "BRD-K97936712__VCAP__trt_cp                   -3.313371\n",
       "BRD-K43267173__A549__trt_cp                   -2.390900\n",
       "BRD-K36354764__MCF7__trt_cp                   -3.101150\n",
       "BRD-K69516039__MCF7__trt_cp                   -2.021250\n",
       "BRD-K89224880__VCAP__trt_cp                   -2.112464\n",
       "BRD-K31600199__A549__trt_cp                   -2.020900\n",
       "BRD-K96213252__PC3__trt_cp                    -2.565480\n",
       "BRD-K01265221__VCAP__trt_cp                   -2.176564\n",
       "BRD-K49403449__VCAP__trt_cp                   -2.060382\n",
       "doxylamine__MCF7__trt_cp                      -2.074550\n",
       "BRD-K02223034__A549__trt_cp                   -2.238800\n",
       "BRD-K25731886__A549__trt_cp                   -4.073600\n",
       "alvocidib__A549__trt_cp                       -3.286200\n",
       "BRD-K04534322__NEU__trt_cp                    -2.297000\n",
       "doxercalciferol__NEU__trt_cp                  -2.532200\n",
       "BRD-K25731886__NEU__trt_cp                    -2.935900\n",
       "fludarabine__NEU__trt_cp                      -2.533750\n",
       "vorinostat__NEU__trt_cp                       -2.218620\n",
       "BRD-K98731749__NEU__trt_cp                    -3.041465\n",
       "HU-211__NPC__trt_cp                           -2.471365\n",
       "panobinostat__NPC__trt_cp                     -2.327604\n",
       "MD-II-038__NPC__trt_cp                        -2.662000\n",
       "vorinostat__NPC__trt_cp                       -3.182482\n",
       "BRD-K36767861__PHH__trt_cp                    -3.222438\n",
       "BRD-K76926998__PHH__trt_cp                    -2.428900\n",
       "BRD-K02223034__SKB__trt_cp                    -2.220776\n",
       "SA-1447005__VCAP__trt_cp                      -2.625348\n",
       "KM-01366__A549__trt_cp                        -2.407488\n",
       "cilomilast__A549__trt_cp                      -2.377500\n",
       "STOCK1S-03920__MCF7__trt_cp                   -2.238906\n",
       "BRD-A68274214__NEU__trt_cp                    -2.049750\n",
       "F-1061-0166__NEU__trt_cp                      -2.821000\n",
       "danusertib__NEU__trt_cp                       -2.525500\n",
       "daunorubicin__NEU__trt_cp                     -3.230900\n",
       "BRD-K03176945__NPC__trt_cp                    -3.337900\n",
       "daunorubicin__NPC__trt_cp                     -2.862800\n",
       "YM-155__NPC__trt_cp                           -2.259500\n",
       "BRD-K18163752__VCAP__trt_cp                   -2.160134\n",
       "parthenolide-(alternate-stereo)__VCAP__trt_cp -2.302193\n",
       "fenretinide__A549__trt_cp                     -2.163292\n",
       "EI-231__NEU__trt_cp                           -2.552800\n",
       "STK-397047__NEU__trt_cp                       -2.067650\n",
       "HO-013__NEU__trt_cp                           -2.231300\n",
       "SB-590885__NPC__trt_cp                        -2.488000\n",
       "A-443644__NPC__trt_cp                         -3.773600\n",
       "crizotinib__NPC__trt_cp                       -2.158628\n",
       "SB-239063__NPC__trt_cp                        -2.090600\n",
       "fenretinide__NPC__trt_cp                      -2.259500\n",
       "WZ-3105__NPC__trt_cp                          -2.444200\n",
       "torin-2__PHH__trt_cp                          -2.098830\n",
       "linifanib__PHH__trt_cp                        -2.263827\n",
       "BRD-K07061353__VCAP__trt_cp                   -2.104658\n",
       "mitotane__A549__trt_cp                        -2.035658\n",
       "nocodazole__NPC__trt_cp                       -2.571381\n",
       "penfluridol__NPC__trt_cp                      -4.722900\n",
       "podophyllotoxin__NPC__trt_cp                  -2.724479\n",
       "butoconazole__PHH__trt_cp                     -2.217050\n",
       "vinblastine__PHH__trt_cp                      -2.215100\n",
       "paroxetine__PHH__trt_cp                       -2.036100\n",
       "dicyclohexylurea__SKB__trt_cp                 -2.763450\n",
       "anisomycin__ASC__trt_cp                       -2.111786\n",
       "LFM-A13__NEU__trt_cp                          -4.818600\n",
       "bisindolylmaleimide-ix__NEU__trt_cp           -2.053642\n",
       "BML-257__NEU__trt_cp                          -5.686600\n",
       "caffeic-acid__NEU__trt_cp                     -2.145504\n",
       "BRD-K93541117__NEU__trt_cp                    -2.055563\n",
       "teniposide__NPC__trt_cp                       -2.629349\n",
       "aminopurvalanol-a__NPC__trt_cp                -2.470100\n",
       "dextromethorphan__NPC__trt_cp                 -2.140700\n",
       "LY-2183240__NPC__trt_cp                       -2.371386\n",
       "methyl-2,5-dihydroxycinnamate__NPC__trt_cp    -2.420496\n",
       "mocimycin__A549__trt_cp                       -2.049930\n",
       "calycanthine__A549__trt_cp                    -2.105199\n",
       "L-701252__ASC__trt_cp                         -4.062200\n",
       "BMY-14802__NPC__trt_cp                        -2.252357\n",
       "KF-38789__NPC__trt_cp                         -2.480147\n",
       "ryuvidine__NPC__trt_cp                        -2.028050\n",
       "ER-27319__NPC__trt_cp                         -2.306100\n",
       "SYK-inhibitor__NPC__trt_cp                    -2.415230\n",
       "SB-431542__NPC__trt_cp                        -3.160610\n",
       "BMY-14802__PHH__trt_cp                        -2.118578\n",
       "ER-27319__PHH__trt_cp                         -2.346425\n",
       "milrinone__PHH__trt_cp                        -2.402087\n",
       "CS-110266__ASC__trt_cp                        -3.594700\n",
       "gitoxigenin__NPC__trt_cp                      -2.226500\n",
       "cymarin__NPC__trt_cp                          -2.899550\n",
       "amiodarone__PHH__trt_cp                       -3.548564\n",
       "tranilast__PHH__trt_cp                        -3.020363\n",
       "DMeOB__PHH__trt_cp                            -2.837748\n",
       "DCEBIO__PHH__trt_cp                           -4.610377\n",
       "hexamethyleneamiloride__PHH__trt_cp           -2.153800\n",
       "EMF-bca1-16__VCAP__trt_cp                     -2.197326\n",
       "LY-2140023__VCAP__trt_cp                      -2.124259\n",
       "aminohippuric-acid__PC3__trt_cp               -2.049750\n",
       "triphenyl-tin__HA1E__trt_cp                   -2.005953\n",
       "tributyltin__HA1E__trt_cp                     -3.094550\n",
       "BRD-K86671899__A375__trt_cp                   -2.286732\n",
       "BRD-K23985857__HT29__trt_cp                   -2.080577\n",
       "BRD-K62242359__HT29__trt_cp                   -2.488255\n",
       "BRD-K90734091__HT29__trt_cp                   -2.162145\n",
       "BRD-K00381581__NEU__trt_cp                    -2.035250\n",
       "BRD-K38294617__NEU__trt_cp                    -2.160950\n",
       "BRD-K48673964__NEU__trt_cp                    -2.307650\n",
       "BRD-K88822846__NEU__trt_cp                    -2.472500\n",
       "BRD-K86048057__NPC__trt_cp                    -2.548067\n",
       "BRD-K29423519__A549__trt_cp                   -2.396733\n",
       "BRD-K73276569__A549__trt_cp                   -2.140650\n",
       "BRD-K15524596__NEU__trt_cp                    -2.229450\n",
       "BRD-K79532217__NEU__trt_cp                    -2.014550\n",
       "BRD-K68504618__NPC__trt_cp                    -2.003538\n",
       "BRD-K80169513__NPC__trt_cp                    -2.226549\n",
       "BRD-K81408913__NPC__trt_cp                    -2.731183\n",
       "BRD-K85205404__NPC__trt_cp                    -2.147588\n",
       "BRD-K36620425__VCAP__trt_cp                   -2.140300\n",
       "BRD-K18545493__VCAP__trt_cp                   -2.066177\n",
       "BRD-K97255584__VCAP__trt_cp                   -2.006109\n",
       "peruvoside__VCAP__trt_cp                      -2.691100\n",
       "lanatoside-c__VCAP__trt_cp                    -2.178000\n",
       "BRD-K34314104__VCAP__trt_cp                   -3.205300\n",
       "BRD-K26510616__PC3__trt_cp                    -2.360850\n",
       "QL-X-138__MCF10A__trt_cp                      -2.111429\n",
       "PD-0325901__BT20__trt_cp                      -2.014726\n",
       "ON-01910__BT20__trt_cp                        -2.140587\n",
       "SA-1925610__MCF7__trt_cp                      -2.547700\n",
       "SA-3676__NKDBA__trt_cp                        -2.158700\n",
       "SA-1459213__MCF7__trt_cp                      -2.359300\n",
       "BRD-A12426960__FIBRNPC__trt_cp                -2.284850\n",
       "ephedrine__FIBRNPC__trt_cp                    -2.402400\n",
       "6-nitrodopamine__FIBRNPC__trt_cp              -2.209700\n",
       "BRD-K19653414__FIBRNPC__trt_cp                -2.113800\n",
       "n-bromoacetyltryptamine__FIBRNPC__trt_cp      -2.205550\n",
       "BRD-A42610307__NEU__trt_cp                    -2.110316\n",
       "BRD-A86146706__NEU__trt_cp                    -2.311600\n",
       "BG-1003__NEU__trt_cp                          -2.279669\n",
       "SR-12813__NEU__trt_cp                         -2.061450\n",
       "LBH-589__NEU__trt_cp                          -2.051542\n",
       "BG-1003__NPC__trt_cp                          -2.050464\n",
       "LBH-589__NPC__trt_cp                          -2.351810\n",
       "BG-1008__NEU__trt_cp                          -2.506527\n",
       "temozolomide__NEU__trt_cp                     -2.358148\n",
       "BG-1005__NEU__trt_cp                          -2.408175\n",
       "BG-1025__NEU__trt_cp                          -2.330200\n",
       "C2-dihydroceramide__NEU__trt_cp               -2.060200\n",
       "BG-1030__NEU__trt_cp                          -2.047566\n",
       "oxamflatin__NPC__trt_cp                       -2.670142\n",
       "BG-1029__NPC__trt_cp                          -2.168213\n",
       "BG-1006__NPC__trt_cp                          -2.664152\n",
       "BML-284__NPC__trt_cp                          -4.036828\n",
       "M-344__NPC__trt_cp                            -2.041860\n",
       "BG-1025__NPC__trt_cp                          -2.107575\n",
       "BG-1026__NPC__trt_cp                          -2.440128\n",
       "NCH-51__NPC__trt_cp                           -2.122013\n",
       "BG-1007__NPC__trt_cp                          -2.229874\n",
       "BG-1028__NPC__trt_cp                          -2.391268\n",
       "BG-1027__NPC__trt_cp                          -2.334610\n",
       "tert-butylhydroquinone__MCF7__trt_cp          -3.080953\n",
       "panobinostat__A375__trt_cp                    -2.063759\n",
       "staurosporine__A375__trt_cp                   -3.507200\n",
       "apicidin__A375__trt_cp                        -2.681550\n",
       "BRD-K57064803__MCF7__trt_cp                   -2.356925\n",
       "alpha-tocopherol__MCF7__trt_cp                -2.502400\n",
       "JMW-MITF1__MCF7__trt_cp                       -2.199600\n",
       "alpha-tocopherol__PC3__trt_cp                 -2.310900\n",
       "bortezomib__PC3__trt_cp                       -3.855000\n",
       "\n",
       "$HOXC5\n",
       "                                                                         drug\n",
       "aminomethyltransferase__HA1E__trt_cp     aminomethyltransferase__HA1E__trt_cp\n",
       "ARP-101__HA1E__trt_cp                                   ARP-101__HA1E__trt_cp\n",
       "homoharringtonine__HA1E__trt_cp               homoharringtonine__HA1E__trt_cp\n",
       "CFM-1571__HCC515__trt_cp                             CFM-1571__HCC515__trt_cp\n",
       "apoptosis-activator-II__HCC515__trt_cp apoptosis-activator-II__HCC515__trt_cp\n",
       "puromycin__VCAP__trt_cp                               puromycin__VCAP__trt_cp\n",
       "NSC-632839__VCAP__trt_cp                             NSC-632839__VCAP__trt_cp\n",
       "NNC-711__VCAP__trt_cp                                   NNC-711__VCAP__trt_cp\n",
       "MG-132__VCAP__trt_cp                                     MG-132__VCAP__trt_cp\n",
       "Ro-15-4513__VCAP__trt_cp                             Ro-15-4513__VCAP__trt_cp\n",
       "R-59022__HA1E__trt_cp                                   R-59022__HA1E__trt_cp\n",
       "cucurbitacin-i__MCF7__trt_cp                     cucurbitacin-i__MCF7__trt_cp\n",
       "SCH-79797__MCF7__trt_cp                               SCH-79797__MCF7__trt_cp\n",
       "BRD-K19290969__A549__trt_cp                       BRD-K19290969__A549__trt_cp\n",
       "BIX-02188__VCAP__trt_cp                               BIX-02188__VCAP__trt_cp\n",
       "BRD-A98444709__A549__trt_cp                       BRD-A98444709__A549__trt_cp\n",
       "BRD-K18726304__MCF7__trt_cp                       BRD-K18726304__MCF7__trt_cp\n",
       "toremifene__MCF7__trt_cp                             toremifene__MCF7__trt_cp\n",
       "BRD-K32896438__MCF7__trt_cp                       BRD-K32896438__MCF7__trt_cp\n",
       "RAN-27__NEU__trt_cp                                       RAN-27__NEU__trt_cp\n",
       "BRD-K44893543__NEU__trt_cp                         BRD-K44893543__NEU__trt_cp\n",
       "cytochalasin-d__MCF7__trt_cp                     cytochalasin-d__MCF7__trt_cp\n",
       "ST-4029010__NEU__trt_cp                               ST-4029010__NEU__trt_cp\n",
       "sorafenib__VCAP__trt_cp                               sorafenib__VCAP__trt_cp\n",
       "BG-FA-0953__VCAP__trt_cp                             BG-FA-0953__VCAP__trt_cp\n",
       "WYE-354__ASC__trt_cp                                     WYE-354__ASC__trt_cp\n",
       "WYE-125132__MCF7__trt_cp                             WYE-125132__MCF7__trt_cp\n",
       "verrucarin-a__NEU__trt_cp                           verrucarin-a__NEU__trt_cp\n",
       "mirin__VCAP__trt_cp                                       mirin__VCAP__trt_cp\n",
       "CGP-71683__MCF7__trt_cp                               CGP-71683__MCF7__trt_cp\n",
       "NSC-663284__PHH__trt_cp                               NSC-663284__PHH__trt_cp\n",
       "proadifen__ASC__trt_cp                                 proadifen__ASC__trt_cp\n",
       "anisomycin__NEU__trt_cp                               anisomycin__NEU__trt_cp\n",
       "formoterol__SKB__trt_cp                               formoterol__SKB__trt_cp\n",
       "FCCP__MCF7__trt_cp                                         FCCP__MCF7__trt_cp\n",
       "diphenyleneiodonium__MCF7__trt_cp           diphenyleneiodonium__MCF7__trt_cp\n",
       "NSC-94258__MCF7__trt_cp                               NSC-94258__MCF7__trt_cp\n",
       "SQ-22536__NPC__trt_cp                                   SQ-22536__NPC__trt_cp\n",
       "pyrvinium__MCF7__trt_cp                               pyrvinium__MCF7__trt_cp\n",
       "BRD-K00835201__NEU__trt_cp                         BRD-K00835201__NEU__trt_cp\n",
       "BRD-K75264577__NEU__trt_cp                         BRD-K75264577__NEU__trt_cp\n",
       "BRD-K01477275__NPC__trt_cp                         BRD-K01477275__NPC__trt_cp\n",
       "BRD-K02519835__VCAP__trt_cp                       BRD-K02519835__VCAP__trt_cp\n",
       "motesanib__HS578T__trt_cp                           motesanib__HS578T__trt_cp\n",
       "SYK-inhibitor__SKBR3__trt_cp                     SYK-inhibitor__SKBR3__trt_cp\n",
       "ENMD-2076__A375__trt_cp                               ENMD-2076__A375__trt_cp\n",
       "BRD-K99636700__HCC515__trt_cp                   BRD-K99636700__HCC515__trt_cp\n",
       "apicidin__HEPG2__trt_cp                               apicidin__HEPG2__trt_cp\n",
       "avrainvillamide-analog-4__MCF7__trt_cp avrainvillamide-analog-4__MCF7__trt_cp\n",
       "                                          zscore\n",
       "aminomethyltransferase__HA1E__trt_cp   -2.349426\n",
       "ARP-101__HA1E__trt_cp                  -2.420850\n",
       "homoharringtonine__HA1E__trt_cp        -2.545411\n",
       "CFM-1571__HCC515__trt_cp               -2.027797\n",
       "apoptosis-activator-II__HCC515__trt_cp -2.027338\n",
       "puromycin__VCAP__trt_cp                -3.208967\n",
       "NSC-632839__VCAP__trt_cp               -2.437900\n",
       "NNC-711__VCAP__trt_cp                  -2.587158\n",
       "MG-132__VCAP__trt_cp                   -2.497801\n",
       "Ro-15-4513__VCAP__trt_cp               -2.462467\n",
       "R-59022__HA1E__trt_cp                  -2.440392\n",
       "cucurbitacin-i__MCF7__trt_cp           -2.504937\n",
       "SCH-79797__MCF7__trt_cp                -3.103155\n",
       "BRD-K19290969__A549__trt_cp            -2.442208\n",
       "BIX-02188__VCAP__trt_cp                -2.021193\n",
       "BRD-A98444709__A549__trt_cp            -2.181950\n",
       "BRD-K18726304__MCF7__trt_cp            -2.498750\n",
       "toremifene__MCF7__trt_cp               -2.111762\n",
       "BRD-K32896438__MCF7__trt_cp            -2.568452\n",
       "RAN-27__NEU__trt_cp                    -2.057970\n",
       "BRD-K44893543__NEU__trt_cp             -2.403568\n",
       "cytochalasin-d__MCF7__trt_cp           -2.524929\n",
       "ST-4029010__NEU__trt_cp                -2.160550\n",
       "sorafenib__VCAP__trt_cp                -2.387828\n",
       "BG-FA-0953__VCAP__trt_cp               -2.010978\n",
       "WYE-354__ASC__trt_cp                   -2.030976\n",
       "WYE-125132__MCF7__trt_cp               -2.019033\n",
       "verrucarin-a__NEU__trt_cp              -2.535550\n",
       "mirin__VCAP__trt_cp                    -2.051119\n",
       "CGP-71683__MCF7__trt_cp                -2.191356\n",
       "NSC-663284__PHH__trt_cp                -2.232050\n",
       "proadifen__ASC__trt_cp                 -2.171099\n",
       "anisomycin__NEU__trt_cp                -2.530992\n",
       "formoterol__SKB__trt_cp                -2.052984\n",
       "FCCP__MCF7__trt_cp                     -2.068842\n",
       "diphenyleneiodonium__MCF7__trt_cp      -2.738179\n",
       "NSC-94258__MCF7__trt_cp                -2.348442\n",
       "SQ-22536__NPC__trt_cp                  -2.024650\n",
       "pyrvinium__MCF7__trt_cp                -2.287450\n",
       "BRD-K00835201__NEU__trt_cp             -2.013800\n",
       "BRD-K75264577__NEU__trt_cp             -2.051050\n",
       "BRD-K01477275__NPC__trt_cp             -2.038408\n",
       "BRD-K02519835__VCAP__trt_cp            -2.148807\n",
       "motesanib__HS578T__trt_cp              -2.047123\n",
       "SYK-inhibitor__SKBR3__trt_cp           -2.655849\n",
       "ENMD-2076__A375__trt_cp                -2.061680\n",
       "BRD-K99636700__HCC515__trt_cp          -2.166222\n",
       "apicidin__HEPG2__trt_cp                -2.335700\n",
       "avrainvillamide-analog-4__MCF7__trt_cp -2.152519\n"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "####screen the drug with decreased the TF's expression\n",
    "drug.lists <- list()\n",
    "for(i in 1:nrow(lincs.TF.matrix)){\n",
    "    zscore <- lincs.TF.matrix[i,]\n",
    "    info <- data.frame(drug = colnames(lincs.TF.matrix), zscore = zscore)\n",
    "    sig.drug <- which(info$zscore < -2) \n",
    "    if(length(sig.drug)>0){\n",
    "        sig.info <- info[sig.drug,]\n",
    "    }else{\n",
    "        sig.info <- NULL\n",
    "    }\n",
    "    drug.lists <- c(drug.lists, list(sig.info))\n",
    "}\n",
    "names(drug.lists) <- rownames(lincs.TF.matrix)\n",
    "drug.lists"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "61e3f9ea-c347-4e6e-bb49-0119d7e72528",
   "metadata": {
    "collapsed": true,
    "execution": {
     "iopub.execute_input": "2021-09-22T03:01:15.962166Z",
     "iopub.status.busy": "2021-09-22T03:01:15.961282Z",
     "iopub.status.idle": "2021-09-22T03:01:15.991988Z",
     "shell.execute_reply": "2021-09-22T03:01:15.990966Z"
    },
    "jupyter": {
     "outputs_hidden": true,
     "source_hidden": true
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "drugs\n",
       "                  BRD-A30083233__VCAP__trt_cp \n",
       "                                            6 \n",
       "parthenolide-(alternate-stereo)__VCAP__trt_cp \n",
       "                                            6 \n",
       "                         BML-257__NEU__trt_cp \n",
       "                                            5 \n",
       "                        tubacin__VCAP__trt_cp \n",
       "                                            5 \n",
       "               1-phenylbiguanide__PHH__trt_cp \n",
       "                                            4 \n",
       "                  BRD-A68274214__VCAP__trt_cp \n",
       "                                            4 \n",
       "                  BRD-K25731886__A549__trt_cp \n",
       "                                            4 \n",
       "                      genistein__VCAP__trt_cp \n",
       "                                            4 \n",
       "              homoharringtonine__HA1E__trt_cp \n",
       "                                            4 \n",
       "                    kitasamycin__VCAP__trt_cp \n",
       "                                            4 \n",
       "                         LFM-A13__NEU__trt_cp \n",
       "                                            4 \n",
       "                      NSC-663284__PHH__trt_cp \n",
       "                                            4 \n",
       "                      anisomycin__NEU__trt_cp \n",
       "                                            3 \n",
       "                  BRD-K02519835__VCAP__trt_cp \n",
       "                                            3 \n",
       "                  BRD-K16180117__VCAP__trt_cp \n",
       "                                            3 \n",
       "                   BRD-K39345836__PC3__trt_cp \n",
       "                                            3 \n",
       "                   BRD-K44893543__NEU__trt_cp \n",
       "                                            3 \n",
       "                  BRD-K52914903__VCAP__trt_cp \n",
       "                                            3 \n",
       "                   BRD-K88278225__PC3__trt_cp \n",
       "                                            3 \n",
       "                      CGP-71683__MCF7__trt_cp \n",
       "                                            3 \n",
       "                  cucurbitacin-i__PHH__trt_cp \n",
       "                                            3 \n",
       "                        emetine__HA1E__trt_cp \n",
       "                                            3 \n",
       "                          IC-261__PHH__trt_cp \n",
       "                                            3 \n",
       "                   lansoprazole__VCAP__trt_cp \n",
       "                                            3 \n",
       "                         NAN-190__PHH__trt_cp \n",
       "                                            3 \n",
       "                       PD-173074__PHH__trt_cp \n",
       "                                            3 \n",
       "                     probenecid__A549__trt_cp \n",
       "                                            3 \n",
       "                      SEW-05685__VCAP__trt_cp \n",
       "                                            3 \n",
       "                      SJ-172550__VCAP__trt_cp \n",
       "                                            3 \n",
       "                    treprostinil__PHH__trt_cp \n",
       "                                            3 \n",
       "                 trichostatin-a__HA1E__trt_cp \n",
       "                                            3 \n",
       "                    verrucarin-a__NEU__trt_cp \n",
       "                                            3 \n",
       "                    verteporfin__VCAP__trt_cp \n",
       "                                            3 \n",
       "                     vinblastine__PHH__trt_cp \n",
       "                                            3 \n",
       "                       acitretin__NEU__trt_cp \n",
       "                                            2 \n",
       "                       apicidin__A375__trt_cp \n",
       "                                            2 \n",
       "                      apicidin__HEPG2__trt_cp \n",
       "                                            2 \n",
       "                      AS-605240__VCAP__trt_cp \n",
       "                                            2 \n",
       "       avrainvillamide-analog-4__MCF7__trt_cp \n",
       "                                            2 \n",
       "                 BCL2-inhibitor__VCAP__trt_cp \n",
       "                                            2 \n",
       "                         BG-1003__NEU__trt_cp \n",
       "                                            2 \n",
       "                         BG-1006__NPC__trt_cp \n",
       "                                            2 \n",
       "                       BMY-14802__PHH__trt_cp \n",
       "                                            2 \n",
       "                      bortezomib__PC3__trt_cp \n",
       "                                            2 \n",
       "                  BRD-A16581344__A549__trt_cp \n",
       "                                            2 \n",
       "                  BRD-A38425832__VCAP__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K03176945__NPC__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K04534322__NEU__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K05153001__A549__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K05402890__HT29__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K16827616__HT29__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K25731886__NEU__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K26684619__CD34__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K34314104__VCAP__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K44494044__NEU__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K47764688__VCAP__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K58247702__VCAP__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K58279162__NEU__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K59556282__NEU__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K67236950__HT29__trt_cp \n",
       "                                            2 \n",
       "                  BRD-K72307842__HA1E__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K75907833__PC3__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K96213252__PC3__trt_cp \n",
       "                                            2 \n",
       "                   BRD-K98731749__NEU__trt_cp \n",
       "                                            2 \n",
       "                    brefeldin-a__HA1E__trt_cp \n",
       "                                            2 \n",
       "                     caffeine__HCC515__trt_cp \n",
       "                                            2 \n",
       "                      cephaeline__ASC__trt_cp \n",
       "                                            2 \n",
       "                     cilomilast__A549__trt_cp \n",
       "                                            2 \n",
       "                 cucurbitacin-i__MCF7__trt_cp \n",
       "                                            2 \n",
       "              cyclopiazonic-acid__NEU__trt_cp \n",
       "                                            2 \n",
       "                           DMeOB__PHH__trt_cp \n",
       "                                            2 \n",
       "                     EMF-BCA1-57__ASC__trt_cp \n",
       "                                            2 \n",
       "                      GW-405833__HA1E__trt_cp \n",
       "                                            2 \n",
       "                         GW-7647__PHH__trt_cp \n",
       "                                            2 \n",
       "                         GW-7647__SKB__trt_cp \n",
       "                                            2 \n",
       "                  helveticoside__HA1E__trt_cp \n",
       "                                            2 \n",
       "                    HG-5-113-01__BT20__trt_cp \n",
       "                                            2 \n",
       "                          HO-013__NEU__trt_cp \n",
       "                                            2 \n",
       "                     ipsapirone__HT29__trt_cp \n",
       "                                            2 \n",
       "                      JMW-MITF1__MCF7__trt_cp \n",
       "                                            2 \n",
       "               kinetin-riboside__HA1E__trt_cp \n",
       "                                            2 \n",
       "                     KU-C103853__MCF7__trt_cp \n",
       "                                            2 \n",
       "                        L-701252__PHH__trt_cp \n",
       "                                            2 \n",
       "                           M-344__NEU__trt_cp \n",
       "                                            2 \n",
       "                       mitotane__A549__trt_cp \n",
       "                                            2 \n",
       "                    MW-STK33-2B__A549__trt_cp \n",
       "                                            2 \n",
       "                   panobinostat__A375__trt_cp \n",
       "                                            2 \n",
       "                  panobinostat__HEPG2__trt_cp \n",
       "                                            2 \n",
       "                    panobinostat__NPC__trt_cp \n",
       "                                            2 \n",
       "                      PCI-24781__VCAP__trt_cp \n",
       "                                            2 \n",
       "                     PNU-96415E__HA1E__trt_cp \n",
       "                                            2 \n",
       "                          RAN-27__NEU__trt_cp \n",
       "                                            2 \n",
       "                     SA-1459213__MCF7__trt_cp \n",
       "                                            2 \n",
       "                       SB-239063__NEU__trt_cp \n",
       "                                            2 \n",
       "                       SB-239063__PHH__trt_cp \n",
       "                                            2 \n",
       "                       scriptaid__ASC__trt_cp \n",
       "                                            2 \n",
       "                      scriptaid__HA1E__trt_cp \n",
       "                                            2 \n",
       "                        SQ-22536__NPC__trt_cp \n",
       "                                            2 \n",
       "                  STOCK1S-03920__MCF7__trt_cp \n",
       "                                            2 \n",
       "                      terguride__A549__trt_cp \n",
       "                                            2 \n",
       "                      TG-100115__VCAP__trt_cp \n",
       "                                            2 \n",
       "                thiocolchicoside__NPC__trt_cp \n",
       "                                            2 \n",
       "                thiocolchicoside__SKB__trt_cp \n",
       "                                            2 \n",
       "                     vorinostat__HA1E__trt_cp \n",
       "                                            2 \n",
       "                          YM-155__NPC__trt_cp \n",
       "                                            2 \n",
       "                    zoxazolamine__PHH__trt_cp \n",
       "                                            2 \n",
       "               1-phenylbiguanide__NPC__trt_cp \n",
       "                                            1 \n",
       "          10-hydroxycamptothecin__PHH__trt_cp \n",
       "                                            1 \n",
       "      15-delta-prostaglandin-j2__HA1E__trt_cp \n",
       "                                            1 \n",
       "             6-nitrodopamine__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                       A-23187__HEPG2__trt_cp \n",
       "                                            1 \n",
       "                        A-23187__HUH7__trt_cp \n",
       "                                            1 \n",
       "                        A-443644__NPC__trt_cp \n",
       "                                            1 \n",
       "                        ABT-751__HT29__trt_cp \n",
       "                                            1 \n",
       "                      acitretin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                         AG-592__HA1E__trt_cp \n",
       "                                            1 \n",
       "               AKT-inhibitor-IV__HT29__trt_cp \n",
       "                                            1 \n",
       "                 alendronic-acid__NEU__trt_cp \n",
       "                                            1 \n",
       "           alpha-linolenic-acid__A549__trt_cp \n",
       "                                            1 \n",
       "               alpha-tocopherol__MCF7__trt_cp \n",
       "                                            1 \n",
       "                alpha-tocopherol__PC3__trt_cp \n",
       "                                            1 \n",
       "                    alvespimycin__PHH__trt_cp \n",
       "                                            1 \n",
       "                      alvocidib__A549__trt_cp \n",
       "                                            1 \n",
       "                      amcinonide__PHH__trt_cp \n",
       "                                            1 \n",
       "                     amcinonide__VCAP__trt_cp \n",
       "                                            1 \n",
       "              aminohippuric-acid__PC3__trt_cp \n",
       "                                            1 \n",
       "         aminomethyltransferase__HA1E__trt_cp \n",
       "                                            1 \n",
       "                 aminopentamide__A549__trt_cp \n",
       "                                            1 \n",
       "               aminopurvalanol-a__NPC__trt_cp \n",
       "                                            1 \n",
       "                      amiodarone__PHH__trt_cp \n",
       "                                            1 \n",
       "                    amisulpride__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     amodiaquine__NEU__trt_cp \n",
       "                                            1 \n",
       "                       amthamine__PHH__trt_cp \n",
       "                                            1 \n",
       "                     anagrelide__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     androstenol__NEU__trt_cp \n",
       "                                            1 \n",
       "                      anisomycin__ASC__trt_cp \n",
       "                                            1 \n",
       "                     anisomycin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                      anisomycin__SKB__trt_cp \n",
       "                                            1 \n",
       "                     anthothecol__PHH__trt_cp \n",
       "                                            1 \n",
       "                    apicidin__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                       apicidin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       apicidin__HT29__trt_cp \n",
       "                                            1 \n",
       "                        apicidin__NEU__trt_cp \n",
       "                                            1 \n",
       "                        apigenin__NEU__trt_cp \n",
       "                                            1 \n",
       "       apoptosis-activator-II__HCC515__trt_cp \n",
       "                                            1 \n",
       "                        ARP-101__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       AS-604850__ASC__trt_cp \n",
       "                                            1 \n",
       "                            AVA__HA1E__trt_cp \n",
       "                                            1 \n",
       "       avrainvillamide-analog-3__A375__trt_cp \n",
       "                                            1 \n",
       "                     benazepril__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    beta-alanine__NEU__trt_cp \n",
       "                                            1 \n",
       "                   betamethasone__PHH__trt_cp \n",
       "                                            1 \n",
       "                         BG-1003__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1005__NEU__trt_cp \n",
       "                                            1 \n",
       "                         BG-1007__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1008__NEU__trt_cp \n",
       "                                            1 \n",
       "                         BG-1025__NEU__trt_cp \n",
       "                                            1 \n",
       "                         BG-1025__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1026__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1027__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1028__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1029__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BG-1030__NEU__trt_cp \n",
       "                                            1 \n",
       "                     BG-FA-0953__VCAP__trt_cp \n",
       "                                            1 \n",
       "                          BH3I-1__PHH__trt_cp \n",
       "                                            1 \n",
       "                        BI-2536__A375__trt_cp \n",
       "                                            1 \n",
       "                        BI-2536__A549__trt_cp \n",
       "                                            1 \n",
       "                        BI-2536__BT20__trt_cp \n",
       "                                            1 \n",
       "                         BI-2536__PC3__trt_cp \n",
       "                                            1 \n",
       "          bisindolylmaleimide-ix__NEU__trt_cp \n",
       "                                            1 \n",
       "                      bithionol__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    bithionol__HCC515__trt_cp \n",
       "                                            1 \n",
       "                      BIX-02188__VCAP__trt_cp \n",
       "                                            1 \n",
       "                         BML-257__NPC__trt_cp \n",
       "                                            1 \n",
       "                         BML-284__NPC__trt_cp \n",
       "                                            1 \n",
       "                       BMY-14802__NPC__trt_cp \n",
       "                                            1 \n",
       "                           BNTX__HT29__trt_cp \n",
       "                                            1 \n",
       "                       brazilin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A00474148__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A11095214__MCF7__trt_cp \n",
       "                                            1 \n",
       "               BRD-A12426960__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A16581344__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A21406558__MCF7__trt_cp \n",
       "                                            1 \n",
       "               BRD-A35072120__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A36411721__PHH__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A38425832__MCF7__trt_cp \n",
       "                                            1 \n",
       "               BRD-A40163033__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A42610307__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A43126523__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A51929314__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A58924247__HT29__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A60386802__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A60386802__NPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A68274214__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A72069525__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A73929928__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A77577770__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A79058669__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A81936046__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A84445767__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A86146706__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A93015352__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A93015352__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A94675310__HT29__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A95820578__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A95820578__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-A95937159__NPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-A98444709__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K00381581__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K00381581__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K00835201__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K00954209__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K01265221__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K01477275__NPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K02025760__PC3__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K02117849__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K02223034__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K02223034__SKB__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K03358980__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K03601405__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K04534322__PHH__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K04534322__SKB__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K04676863__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K05002121__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K05353139__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K05402890__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K06592610__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K07061353__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K07161233__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K07259155__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K07877311__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K08438429__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K09460252__SKB__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K10361096__A375__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K10846167__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K13146765__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K13872703__ASC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K14316227__NPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K14704318__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K14842454__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K15524596__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K16346331__PHH__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K16410418__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K17203693__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K18163752__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K18545493__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K18722736__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K18726304__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K19290969__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K19433082__HT29__trt_cp \n",
       "                                            1 \n",
       "               BRD-K19653414__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K19696793__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K19735876__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K20401833__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K21064560__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K21672423__SKB__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K22006123__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K22261046__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K23027438__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K23165181__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K23985857__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K24053449__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K24053449__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K24156250__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K24205443__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K24754728__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K25731886__ASC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K25731886__PHH__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K26510616__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K26767475__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K28452084__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K28772322__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K28841686__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K29423519__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K30126976__A375__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K30704475__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K31290914__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K31600199__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K32598858__PHH__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K32827536__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K32896438__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K33182644__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K33676730__PHH__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K33743361__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K34547533__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K35254025__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K35568648__PHH__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K35568648__SKB__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K35716340__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K36354764__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K36620425__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K36767861__PHH__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K36864553__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K37340241__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K37340241__NPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K37724988__PC3__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K37762845__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K38294617__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K39345836__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K39799535__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K40185230__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K40758391__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K41925105__PC3__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K43253317__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K43267173__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K44261129__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K44366801__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K44575778__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K45114207__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K45114207__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K45205755__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K45230579__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K45627302__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K45842176__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K46814258__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K47512679__NPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K48199208__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K48598367__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K48673964__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K48844671__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K49403449__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K49562544__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K49861754__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K50748030__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K51696048__ASC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K53335770__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K53833301__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K54159704__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K54558492__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K57064803__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K57353465__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K59472190__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K60379529__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K60870698__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K60870698__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K60870698__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K61359235__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K62056344__HUH7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K62242359__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K62578746__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K63000292__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K63770300__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K64985742__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K66426634__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K66658536__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K66884694__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K66884694__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K67010098__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K67118123__PC3__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K67470788__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K67514995__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K67774729__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K67925802__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K68504618__NPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K69406317__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K69516039__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K69795440__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K70891562__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K70917163__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K71265179__HT29__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K71292008__ASC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K73125384__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K73143528__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K73276569__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K74109131__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K74109131__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K74534237__PHH__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K75264577__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K75329208__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K75641083__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K76079827__PC3__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K76236182__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K76264608__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K76691125__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K76926998__PHH__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K77547920__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K78062244__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K78133682__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K78133682__HT29__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K79532217__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K79657514__NPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K80169513__NPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K80962769__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K81408913__NPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K82732294__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K82732294__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K82732294__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K82971429__PHH__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K83589469__HA1E__trt_cp \n",
       "                                            1 \n",
       "                 BRD-K83694683__HEPG2__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K83694683__MCF7__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K84203638__A375__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K85174275__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K85205404__NPC__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K85266146__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K85275009__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K85694079__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K86048057__NPC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K86671899__A375__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K88373420__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K88542532__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K88556033__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K88822846__NEU__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K88899793__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K89107430__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K89224880__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K89326053__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K90734091__HT29__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K91691979__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K91781484__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K91781484__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K92033419__A549__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K92202821__PC3__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K92302554__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K93541117__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K93610587__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K93760529__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K95037415__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K95352812__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K95482240__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K95789946__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K95895342__ASC__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K96041907__HT29__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K96194181__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K96703623__HT29__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K97149069__SKB__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K97255584__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K97936712__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K98645985__A549__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K98731749__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K98945308__NEU__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K98991361__A549__trt_cp \n",
       "                                            1 \n",
       "                BRD-K99636700__HCC515__trt_cp \n",
       "                                            1 \n",
       "                  BRD-K99737413__A375__trt_cp \n",
       "                                            1 \n",
       "                   BRD-K99756483__PC3__trt_cp \n",
       "                                            1 \n",
       "                    brefeldin-a__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     brefeldin-a__PC3__trt_cp \n",
       "                                            1 \n",
       "                      BRL-37344__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         brucine__PC3__trt_cp \n",
       "                                            1 \n",
       "                   budesonide__HCC515__trt_cp \n",
       "                                            1 \n",
       "                        bufalin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    buphenine__HCC515__trt_cp \n",
       "                                            1 \n",
       "                 butoconazole__HCC515__trt_cp \n",
       "                                            1 \n",
       "                    butoconazole__PHH__trt_cp \n",
       "                                            1 \n",
       "                         BX-795__HT29__trt_cp \n",
       "                                            1 \n",
       "              C2-dihydroceramide__NEU__trt_cp \n",
       "                                            1 \n",
       "                      CA-074-Me__A375__trt_cp \n",
       "                                            1 \n",
       "                    caffeic-acid__NEU__trt_cp \n",
       "                                            1 \n",
       "                   calmidazolium__ASC__trt_cp \n",
       "                                            1 \n",
       "                   calycanthine__A549__trt_cp \n",
       "                                            1 \n",
       "                   camptothecin__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     carbetocin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      CAY-10415__VCAP__trt_cp \n",
       "                                            1 \n",
       "                            CCMQ__ASC__trt_cp \n",
       "                                            1 \n",
       "                       cefotiam__MCF7__trt_cp \n",
       "                                            1 \n",
       "                      celecoxib__A549__trt_cp \n",
       "                                            1 \n",
       "                     cephaeline__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    cerivastatin__PC3__trt_cp \n",
       "                                            1 \n",
       "                     CFM-1571__HCC515__trt_cp \n",
       "                                            1 \n",
       "                       CGS-21680__ASC__trt_cp \n",
       "                                            1 \n",
       "                    chelidonine__HT29__trt_cp \n",
       "                                            1 \n",
       "                      chloroxine__ASC__trt_cp \n",
       "                                            1 \n",
       "                     chloroxine__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     ciglitazone__SKB__trt_cp \n",
       "                                            1 \n",
       "                      cinalukast__PHH__trt_cp \n",
       "                                            1 \n",
       "                    cinobufagin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       CL-82198__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     clioquinol__HT29__trt_cp \n",
       "                                            1 \n",
       "                         CMPD-1__A375__trt_cp \n",
       "                                            1 \n",
       "               cortisone-acetate__PC3__trt_cp \n",
       "                                            1 \n",
       "                      crizotinib__NPC__trt_cp \n",
       "                                            1 \n",
       "                       CS-110266__ASC__trt_cp \n",
       "                                            1 \n",
       "                      CT-200783__VCAP__trt_cp \n",
       "                                            1 \n",
       "                 cucurbitacin-i__HT29__trt_cp \n",
       "                                            1 \n",
       "                   cycloheximide__ASC__trt_cp \n",
       "                                            1 \n",
       "                   cycloheximide__NEU__trt_cp \n",
       "                                            1 \n",
       "                   cycloheximide__SKB__trt_cp \n",
       "                                            1 \n",
       "                   cyclopentene__A549__trt_cp \n",
       "                                            1 \n",
       "                        cymarin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         cymarin__NPC__trt_cp \n",
       "                                            1 \n",
       "                  cyproterone__HCC515__trt_cp \n",
       "                                            1 \n",
       "                 cytochalasin-d__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   dactinomycin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      dantrolene__PHH__trt_cp \n",
       "                                            1 \n",
       "                      danusertib__NEU__trt_cp \n",
       "                                            1 \n",
       "                    daunorubicin__NEU__trt_cp \n",
       "                                            1 \n",
       "                    daunorubicin__NPC__trt_cp \n",
       "                                            1 \n",
       "                          DCEBIO__PHH__trt_cp \n",
       "                                            1 \n",
       "                      decitabine__NPC__trt_cp \n",
       "                                            1 \n",
       "                  dehydrocholate__SKB__trt_cp \n",
       "                                            1 \n",
       "                   desoxycortone__NEU__trt_cp \n",
       "                                            1 \n",
       "                   desoxycortone__SKB__trt_cp \n",
       "                                            1 \n",
       "                   dexamethasone__PHH__trt_cp \n",
       "                                            1 \n",
       "                     dexrazoxane__PHH__trt_cp \n",
       "                                            1 \n",
       "                dextromethorphan__NPC__trt_cp \n",
       "                                            1 \n",
       "            dibutyrylcyclic-gmp__A549__trt_cp \n",
       "                                            1 \n",
       "                dicyclohexylurea__SKB__trt_cp \n",
       "                                            1 \n",
       "                  digitoxigenin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    digoxigenin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                        digoxin__HA1E__trt_cp \n",
       "                                            1 \n",
       "            dihydroergocristine__HA1E__trt_cp \n",
       "                                            1 \n",
       "               dihydroergotamine__PHH__trt_cp \n",
       "                                            1 \n",
       "                       diltiazem__ASC__trt_cp \n",
       "                                            1 \n",
       "                         diosmin__PC3__trt_cp \n",
       "                                            1 \n",
       "            diphenyleneiodonium__MCF7__trt_cp \n",
       "                                            1 \n",
       "                    dipyridamole__PHH__trt_cp \n",
       "                                            1 \n",
       "                 dorsomorphin__HCC515__trt_cp \n",
       "                                            1 \n",
       "                 doxercalciferol__NEU__trt_cp \n",
       "                                            1 \n",
       "                    doxorubicin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     doxylamine__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     doxylamine__VCAP__trt_cp \n",
       "                                            1 \n",
       "                          EI-231__NEU__trt_cp \n",
       "                                            1 \n",
       "                    EMF-bca1-16__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     EMF-sumo1-9__ASC__trt_cp \n",
       "                                            1 \n",
       "                    emodic-acid__HA1E__trt_cp \n",
       "                                            1 \n",
       "                      ENMD-2076__A375__trt_cp \n",
       "                                            1 \n",
       "                    entinostat__HEPG2__trt_cp \n",
       "                                            1 \n",
       "                   ephedrine__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                epitestosterone__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      eplerenone__SKB__trt_cp \n",
       "                                            1 \n",
       "                        ER-27319__NPC__trt_cp \n",
       "                                            1 \n",
       "                        ER-27319__PHH__trt_cp \n",
       "                                            1 \n",
       "                         esculin__SKB__trt_cp \n",
       "                                            1 \n",
       "                     everolimus__A549__trt_cp \n",
       "                                            1 \n",
       "                     evodiamine__HT29__trt_cp \n",
       "                                            1 \n",
       "                     F-1061-0166__NEU__trt_cp \n",
       "                                            1 \n",
       "                         FCCP__HCC515__trt_cp \n",
       "                                            1 \n",
       "                           FCCP__MCF7__trt_cp \n",
       "                                            1 \n",
       "                      fenoterol__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    fenretinide__A549__trt_cp \n",
       "                                            1 \n",
       "                     fenretinide__NPC__trt_cp \n",
       "                                            1 \n",
       "                  fluconazole__HCC515__trt_cp \n",
       "                                            1 \n",
       "                     fludarabine__NEU__trt_cp \n",
       "                                            1 \n",
       "        fludrocortisone-acetate__A375__trt_cp \n",
       "                                            1 \n",
       "         fluocinolone-acetonide__HT29__trt_cp \n",
       "                                            1 \n",
       "                   fluprostenol__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     formestane__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      formoterol__SKB__trt_cp \n",
       "                                            1 \n",
       "                       FPL-64176__PHH__trt_cp \n",
       "                                            1 \n",
       "                     gitoxigenin__NPC__trt_cp \n",
       "                                            1 \n",
       "                glycocholic-acid__PHH__trt_cp \n",
       "                                            1 \n",
       "           glycodeoxycholic-acid__NEU__trt_cp \n",
       "                                            1 \n",
       "                    GR-159897__HCC515__trt_cp \n",
       "                                            1 \n",
       "                          GR-206__ASC__trt_cp \n",
       "                                            1 \n",
       "                          GR-235__NEU__trt_cp \n",
       "                                            1 \n",
       "             GSK-3-inhibitor-II__HA1E__trt_cp \n",
       "                                            1 \n",
       "            GSK-3-inhibitor-IX__SKBR3__trt_cp \n",
       "                                            1 \n",
       "                  GSK-429286A__HS578T__trt_cp \n",
       "                                            1 \n",
       "                     GSK-461364__VCAP__trt_cp \n",
       "                                            1 \n",
       "                         GW-1929__NPC__trt_cp \n",
       "                                            1 \n",
       "                        GW-1929__VCAP__trt_cp \n",
       "                                            1 \n",
       "                         GW-7647__ASC__trt_cp \n",
       "                                            1 \n",
       "                        GW-9508__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         HA-14-1__NEU__trt_cp \n",
       "                                            1 \n",
       "          hexamethyleneamiloride__PHH__trt_cp \n",
       "                                            1 \n",
       "                         HO-013__A549__trt_cp \n",
       "                                            1 \n",
       "                          HO-013__SKB__trt_cp \n",
       "                                            1 \n",
       "               homoharringtonine__SKB__trt_cp \n",
       "                                            1 \n",
       "                          HU-211__NPC__trt_cp \n",
       "                                            1 \n",
       "         hydrocortisone-valerate__ASC__trt_cp \n",
       "                                            1 \n",
       "                          icilin__NPC__trt_cp \n",
       "                                            1 \n",
       "                       IKK-16__HCC515__trt_cp \n",
       "                                            1 \n",
       "             IKK-2-inhibitor-V__HEPG2__trt_cp \n",
       "                                            1 \n",
       "              IKK-2-inhibitor-V__HUH7__trt_cp \n",
       "                                            1 \n",
       "                    ipratropium__A549__trt_cp \n",
       "                                            1 \n",
       "                     ipratropium__NPC__trt_cp \n",
       "                                            1 \n",
       "                    irsogladine__HA1E__trt_cp \n",
       "                                            1 \n",
       "                isocarboxazid__HCC515__trt_cp \n",
       "                                            1 \n",
       "                      ixazomib__NKDBA__trt_cp \n",
       "                                            1 \n",
       "                     J-104129__HCC515__trt_cp \n",
       "                                            1 \n",
       "                      JAS07-005__VCAP__trt_cp \n",
       "                                            1 \n",
       "                          JX-401__PHH__trt_cp \n",
       "                                            1 \n",
       "                        KF-38789__NPC__trt_cp \n",
       "                                            1 \n",
       "                         khellin__PC3__trt_cp \n",
       "                                            1 \n",
       "                        KI-8751__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         KI-8751__PHH__trt_cp \n",
       "                                            1 \n",
       "               kinetin-riboside__A375__trt_cp \n",
       "                                            1 \n",
       "                       KM-00799__A549__trt_cp \n",
       "                                            1 \n",
       "                       KM-00927__MCF7__trt_cp \n",
       "                                            1 \n",
       "                       KM-01366__A549__trt_cp \n",
       "                                            1 \n",
       "                     KM-04644SC__A549__trt_cp \n",
       "                                            1 \n",
       "                   KU-0060648__HCC515__trt_cp \n",
       "                                            1 \n",
       "                      KU-0060648__PC3__trt_cp \n",
       "                                            1 \n",
       "                     KU-C103656__A549__trt_cp \n",
       "                                            1 \n",
       "                    KU-C103898N__A549__trt_cp \n",
       "                                            1 \n",
       "                     KU-C104140__A549__trt_cp \n",
       "                                            1 \n",
       "                     KUC103424N__A549__trt_cp \n",
       "                                            1 \n",
       "                        L-161982__PHH__trt_cp \n",
       "                                            1 \n",
       "                       L-168049__VCAP__trt_cp \n",
       "                                            1 \n",
       "                        L-701252__ASC__trt_cp \n",
       "                                            1 \n",
       "                     lamotrigine__NEU__trt_cp \n",
       "                                            1 \n",
       "                   lanatoside-c__VCAP__trt_cp \n",
       "                                            1 \n",
       "                       lasalocid__ASC__trt_cp \n",
       "                                            1 \n",
       "                  latrunculin-b__A549__trt_cp \n",
       "                                            1 \n",
       "                         LBH-589__NEU__trt_cp \n",
       "                                            1 \n",
       "                         LBH-589__NPC__trt_cp \n",
       "                                            1 \n",
       "                   LDN-193189__MCF10A__trt_cp \n",
       "                                            1 \n",
       "                      letrozole__A549__trt_cp \n",
       "                                            1 \n",
       "                       leucodin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       linifanib__PHH__trt_cp \n",
       "                                            1 \n",
       "                       lobeline__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     lobendazole__PHH__trt_cp \n",
       "                                            1 \n",
       "                     lobendazole__SKB__trt_cp \n",
       "                                            1 \n",
       "                       LY-165163__NEU__trt_cp \n",
       "                                            1 \n",
       "                     LY-2140023__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     LY-2183240__HT29__trt_cp \n",
       "                                            1 \n",
       "                      LY-2183240__NPC__trt_cp \n",
       "                                            1 \n",
       "                      LY-225910__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      LY-341495__HA1E__trt_cp \n",
       "                                            1 \n",
       "                           M-344__NPC__trt_cp \n",
       "                                            1 \n",
       "                       m-3M3FBS__A549__trt_cp \n",
       "                                            1 \n",
       "                       mafenide__A549__trt_cp \n",
       "                                            1 \n",
       "                      malonoben__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         MAZ-51__HT29__trt_cp \n",
       "                                            1 \n",
       "                       MD-II-038__NPC__trt_cp \n",
       "                                            1 \n",
       "                       meclizine__NPC__trt_cp \n",
       "                                            1 \n",
       "                  mefenamic-acid__PHH__trt_cp \n",
       "                                            1 \n",
       "                 mefenamic-acid__VCAP__trt_cp \n",
       "                                            1 \n",
       "                    melperone__HCC515__trt_cp \n",
       "                                            1 \n",
       "                     mepenzolate__PC3__trt_cp \n",
       "                                            1 \n",
       "  methyl-2,5-dihydroxycinnamate__HA1E__trt_cp \n",
       "                                            1 \n",
       "   methyl-2,5-dihydroxycinnamate__NPC__trt_cp \n",
       "                                            1 \n",
       "                 methylene-blue__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     mevastatin__A549__trt_cp \n",
       "                                            1 \n",
       "                     mexiletine__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         MG-132__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   mifepristone__MCF7__trt_cp \n",
       "                                            1 \n",
       "                       milrinone__PHH__trt_cp \n",
       "                                            1 \n",
       "                          mirin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     mirtazapine__SKB__trt_cp \n",
       "                                            1 \n",
       "                   mitoxantrone__HT29__trt_cp \n",
       "                                            1 \n",
       "                        MK-1775__HT29__trt_cp \n",
       "                                            1 \n",
       "                    mocetinostat__ASC__trt_cp \n",
       "                                            1 \n",
       "                      mocimycin__A549__trt_cp \n",
       "                                            1 \n",
       "                      mometasone__PHH__trt_cp \n",
       "                                            1 \n",
       "                        monensin__PC3__trt_cp \n",
       "                                            1 \n",
       "                    motesanib__HS578T__trt_cp \n",
       "                                            1 \n",
       "                        MPEP__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                       MRS-1220__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     MRS-1845__HCC515__trt_cp \n",
       "                                            1 \n",
       "     n-bromoacetyltryptamine__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                      napelline__HT29__trt_cp \n",
       "                                            1 \n",
       "                        naproxen__PC3__trt_cp \n",
       "                                            1 \n",
       "                   narciclasine__A375__trt_cp \n",
       "                                            1 \n",
       "                   narciclasine__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   narciclasine__HT29__trt_cp \n",
       "                                            1 \n",
       "                     nateglinide__PHH__trt_cp \n",
       "                                            1 \n",
       "                          NCH-51__NPC__trt_cp \n",
       "                                            1 \n",
       "                        NGB-2904__SKB__trt_cp \n",
       "                                            1 \n",
       "                    nicergoline__A549__trt_cp \n",
       "                                            1 \n",
       "                  niclosamide__HCC515__trt_cp \n",
       "                                            1 \n",
       "                      nimesulide__NEU__trt_cp \n",
       "                                            1 \n",
       "                        NNC-711__VCAP__trt_cp \n",
       "                                            1 \n",
       "                  nocodazole__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                      nocodazole__NPC__trt_cp \n",
       "                                            1 \n",
       "                        NS-3694__VCAP__trt_cp \n",
       "                                            1 \n",
       "                       NSC-3852__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     NSC-632839__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     NSC-663284__HA1E__trt_cp \n",
       "                                            1 \n",
       "                      NSC-94258__MCF7__trt_cp \n",
       "                                            1 \n",
       "                      ofloxacin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                       ON-01910__BT20__trt_cp \n",
       "                                            1 \n",
       "                       ON-01910__VCAP__trt_cp \n",
       "                                            1 \n",
       "                 orphenadrine__HCC515__trt_cp \n",
       "                                            1 \n",
       "                        ouabain__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         ouabain__NEU__trt_cp \n",
       "                                            1 \n",
       "                      oxamflatin__NEU__trt_cp \n",
       "                                            1 \n",
       "                      oxamflatin__NPC__trt_cp \n",
       "                                            1 \n",
       "                  oxcarbazepine__MCF7__trt_cp \n",
       "                                            1 \n",
       "                          PAC-1__A375__trt_cp \n",
       "                                            1 \n",
       "           palmitoylethanolamide__NPC__trt_cp \n",
       "                                            1 \n",
       "                    panobinostat__ASC__trt_cp \n",
       "                                            1 \n",
       "                 panobinostat__HCC515__trt_cp \n",
       "                                            1 \n",
       "                   panobinostat__MCF7__trt_cp \n",
       "                                            1 \n",
       "                      parecoxib__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      paroxetine__PHH__trt_cp \n",
       "                                            1 \n",
       "                    PCI-24781__HCC515__trt_cp \n",
       "                                            1 \n",
       "                       PCI-34051__NEU__trt_cp \n",
       "                                            1 \n",
       "                     PD-0325901__BT20__trt_cp \n",
       "                                            1 \n",
       "                   PD-0325901__HS578T__trt_cp \n",
       "                                            1 \n",
       "                 PD-0325901__MDAMB231__trt_cp \n",
       "                                            1 \n",
       "                      PD-198306__HA1E__trt_cp \n",
       "                                            1 \n",
       "                      PD-407824__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       PD-407824__PHH__trt_cp \n",
       "                                            1 \n",
       "                     penfluridol__NPC__trt_cp \n",
       "                                            1 \n",
       "                     perindopril__PHH__trt_cp \n",
       "                                            1 \n",
       "                 periplocymarin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     peruvoside__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   PHA-665752__MCF10A__trt_cp \n",
       "                                            1 \n",
       "                   phentolamine__A549__trt_cp \n",
       "                                            1 \n",
       "               phenylbutazone__HCC515__trt_cp \n",
       "                                            1 \n",
       "                   physostigmine__PHH__trt_cp \n",
       "                                            1 \n",
       "                          PIK-75__PHH__trt_cp \n",
       "                                            1 \n",
       "                     pirarubicin__NEU__trt_cp \n",
       "                                            1 \n",
       "                  pivmecillinam__A549__trt_cp \n",
       "                                            1 \n",
       "                      PNU-22394__VCAP__trt_cp \n",
       "                                            1 \n",
       "                 podophyllotoxin__NPC__trt_cp \n",
       "                                            1 \n",
       "                    prednisolone__PHH__trt_cp \n",
       "                                            1 \n",
       "                       proadifen__ASC__trt_cp \n",
       "                                            1 \n",
       "                       proadifen__NEU__trt_cp \n",
       "                                            1 \n",
       "                       proadifen__NPC__trt_cp \n",
       "                                            1 \n",
       "                       probucol__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   procainamide__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   procaterol__HCC515__trt_cp \n",
       "                                            1 \n",
       "                        PSH-003__HT29__trt_cp \n",
       "                                            1 \n",
       "                      puromycin__VCAP__trt_cp \n",
       "                                            1 \n",
       "                      pyrvinium__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     QL-X-138__MCF10A__trt_cp \n",
       "                                            1 \n",
       "                        QL-X-138__NEU__trt_cp \n",
       "                                            1 \n",
       "                       quinapril__NEU__trt_cp \n",
       "                                            1 \n",
       "                       quinapril__NPC__trt_cp \n",
       "                                            1 \n",
       "                        R-59022__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       ramipril__A549__trt_cp \n",
       "                                            1 \n",
       "                    RDR-01440SC__VCAP__trt_cp \n",
       "                                            1 \n",
       "                    remoxipride__A549__trt_cp \n",
       "                                            1 \n",
       "                     resmethrin__HT29__trt_cp \n",
       "                                            1 \n",
       "                    rifapentine__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     rizatriptan__SKB__trt_cp \n",
       "                                            1 \n",
       "                     Ro-08-2750__HA1E__trt_cp \n",
       "                                            1 \n",
       "                     Ro-15-4513__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   Ro-19-4605__HCC515__trt_cp \n",
       "                                            1 \n",
       "                 rosmarinic-acid__NPC__trt_cp \n",
       "                                            1 \n",
       "                   RS-45041-190__VCAP__trt_cp \n",
       "                                            1 \n",
       "                       RU-28318__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       ryuvidine__NPC__trt_cp \n",
       "                                            1 \n",
       "                     SA-1447005__A549__trt_cp \n",
       "                                            1 \n",
       "                     SA-1447005__VCAP__trt_cp \n",
       "                                            1 \n",
       "                    SA-1456456__NKDBA__trt_cp \n",
       "                                            1 \n",
       "                    SA-1457415__NKDBA__trt_cp \n",
       "                                            1 \n",
       "                      SA-1921617__NEU__trt_cp \n",
       "                                            1 \n",
       "                     SA-1925610__MCF7__trt_cp \n",
       "                                            1 \n",
       "                       SA-3676__NKDBA__trt_cp \n",
       "                                            1 \n",
       "                       SA-419083__NPC__trt_cp \n",
       "                                            1 \n",
       "                       SA-89068__A549__trt_cp \n",
       "                                            1 \n",
       "                  sarmentogenin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                      SB-218078__HA1E__trt_cp \n",
       "                                            1 \n",
       "                       SB-239063__NPC__trt_cp \n",
       "                                            1 \n",
       "                       SB-239063__SKB__trt_cp \n",
       "                                            1 \n",
       "                       SB-415286__SKB__trt_cp \n",
       "                                            1 \n",
       "                       SB-431542__NPC__trt_cp \n",
       "                                            1 \n",
       "                       SB-590885__NPC__trt_cp \n",
       "                                            1 \n",
       "                      SCH-79797__MCF7__trt_cp \n",
       "                                            1 \n",
       "                      scoulerine__PHH__trt_cp \n",
       "                                            1 \n",
       "                   scriptaid__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                     securinine__U937__trt_cp \n",
       "                                            1 \n",
       "                  sertaconazole__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         SKI-II__A549__trt_cp \n",
       "                                            1 \n",
       "                    somatostatin__NEU__trt_cp \n",
       "                                            1 \n",
       "                   sorafenib__HEK293T__trt_cp \n",
       "                                            1 \n",
       "                      sorafenib__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     sphingosine__PC3__trt_cp \n",
       "                                            1 \n",
       "                     spiramide__HEPG2__trt_cp \n",
       "                                            1 \n",
       "                        SR-12813__NEU__trt_cp \n",
       "                                            1 \n",
       "                       SR-142948__ASC__trt_cp \n",
       "                                            1 \n",
       "                       SR-142948__SKB__trt_cp \n",
       "                                            1 \n",
       "                      ST-4029010__NEU__trt_cp \n",
       "                                            1 \n",
       "                         ST-638__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  staurosporine__A375__trt_cp \n",
       "                                            1 \n",
       "                      STK-397047__NEU__trt_cp \n",
       "                                            1 \n",
       "                 strophanthidin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         SU-1498__NPC__trt_cp \n",
       "                                            1 \n",
       "                      sunitinib__A549__trt_cp \n",
       "                                            1 \n",
       "                  SYK-inhibitor__HA1E__trt_cp \n",
       "                                            1 \n",
       "                SYK-inhibitor__HS578T__trt_cp \n",
       "                                            1 \n",
       "                   SYK-inhibitor__NPC__trt_cp \n",
       "                                            1 \n",
       "                 SYK-inhibitor__SKBR3__trt_cp \n",
       "                                            1 \n",
       "                      tacrolimus__NEU__trt_cp \n",
       "                                            1 \n",
       "                      tangeritin__PHH__trt_cp \n",
       "                                            1 \n",
       "                        tegafur__A549__trt_cp \n",
       "                                            1 \n",
       "                    temozolomide__NEU__trt_cp \n",
       "                                            1 \n",
       "                      teniposide__NPC__trt_cp \n",
       "                                            1 \n",
       "         tert-butylhydroquinone__MCF7__trt_cp \n",
       "                                            1 \n",
       "                   tetrabenazine__NEU__trt_cp \n",
       "                                            1 \n",
       "tetrahydrocannabinol-7-oic-acid__HA1E__trt_cp \n",
       "                                            1 \n",
       "                    thalidomide__HA1E__trt_cp \n",
       "                                            1 \n",
       "                   thapsigargin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                thioproperazine__VCAP__trt_cp \n",
       "                                            1 \n",
       "                       thiorphan__ASC__trt_cp \n",
       "                                            1 \n",
       "                   tolcapone__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                        tolmetin__ASC__trt_cp \n",
       "                                            1 \n",
       "                    tolterodine__VCAP__trt_cp \n",
       "                                            1 \n",
       "                     toremifene__MCF7__trt_cp \n",
       "                                            1 \n",
       "                         torin-2__PHH__trt_cp \n",
       "                                            1 \n",
       "                       tranilast__PHH__trt_cp \n",
       "                                            1 \n",
       "                triamcinolone__HCC515__trt_cp \n",
       "                                            1 \n",
       "                    tributyltin__HA1E__trt_cp \n",
       "                                            1 \n",
       "               trichostatin-a__HCC515__trt_cp \n",
       "                                            1 \n",
       "                  trichostatin-a__NPC__trt_cp \n",
       "                                            1 \n",
       "                    trimetozine__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  triphenyl-tin__HA1E__trt_cp \n",
       "                                            1 \n",
       "                         tubacin__PC3__trt_cp \n",
       "                                            1 \n",
       "                  tyrphostin-A9__HUH7__trt_cp \n",
       "                                            1 \n",
       "              tyrphostin-AG-825__MCF7__trt_cp \n",
       "                                            1 \n",
       "                        U-0126__HEPG2__trt_cp \n",
       "                                            1 \n",
       "                       ubenimex__VCAP__trt_cp \n",
       "                                            1 \n",
       "                    vinblastine__HUH7__trt_cp \n",
       "                                            1 \n",
       "                     vinblastine__NEU__trt_cp \n",
       "                                            1 \n",
       "                      vorinostat__NEU__trt_cp \n",
       "                                            1 \n",
       "                      vorinostat__NPC__trt_cp \n",
       "                                            1 \n",
       "                   VU-0400071-3__A549__trt_cp \n",
       "                                            1 \n",
       "                   VU-0420363-1__VCAP__trt_cp \n",
       "                                            1 \n",
       "                   VU-0447127-2__MCF7__trt_cp \n",
       "                                            1 \n",
       "                     WAY-213613__A549__trt_cp \n",
       "                                            1 \n",
       "                         WH-4025__ASC__trt_cp \n",
       "                                            1 \n",
       "                        WHI-P154__PHH__trt_cp \n",
       "                                            1 \n",
       "                          WT-171__PHH__trt_cp \n",
       "                                            1 \n",
       "                     WYE-125132__MCF7__trt_cp \n",
       "                                            1 \n",
       "                         WYE-354__ASC__trt_cp \n",
       "                                            1 \n",
       "                         WZ-3105__NPC__trt_cp \n",
       "                                            1 \n",
       "                        YK-4279__HT29__trt_cp \n",
       "                                            1 \n",
       "                          YM-155__NEU__trt_cp \n",
       "                                            1 \n",
       "                      zaprinast__HA1E__trt_cp \n",
       "                                            1 \n",
       "                  zebularine__FIBRNPC__trt_cp \n",
       "                                            1 \n",
       "                      zosuquidar__PHH__trt_cp \n",
       "                                            1 "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "#### which drug can target multiple TFs at the one experiment\n",
    "multi.TFs <- sapply(drug.lists, function(x){\n",
    "    return(rownames(x))\n",
    "})\n",
    "drugs <- unlist(multi.TFs)\n",
    "sort(table(drugs),decreasing = T)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "id": "a4eda857-0d7a-4a50-bf1b-14d50537f4a8",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:32.923192Z",
     "iopub.status.busy": "2021-09-23T06:22:32.919656Z",
     "iopub.status.idle": "2021-09-23T06:22:33.015687Z",
     "shell.execute_reply": "2021-09-23T06:22:33.014391Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 326 × 5</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
       "\t<tr><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;fct&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td>alpha-tocopherol__MCF7__trt_cp</td><td>ISL1 </td><td>-2.502400</td><td>alpha-tocopherol</td><td>MCF7  </td></tr>\n",
       "\t<tr><td>alpha-tocopherol__PC3__trt_cp </td><td>ISL1 </td><td>-2.310900</td><td>alpha-tocopherol</td><td>PC3   </td></tr>\n",
       "\t<tr><td>anisomycin__NEU__trt_cp       </td><td>HOXC5</td><td>-2.530992</td><td>anisomycin      </td><td>NEU   </td></tr>\n",
       "\t<tr><td>anisomycin__ASC__trt_cp       </td><td>ISL1 </td><td>-2.111786</td><td>anisomycin      </td><td>ASC   </td></tr>\n",
       "\t<tr><td>apicidin__HEPG2__trt_cp       </td><td>HOXC5</td><td>-2.335700</td><td>apicidin        </td><td>HEPG2 </td></tr>\n",
       "\t<tr><td>apicidin__A375__trt_cp        </td><td>ISL1 </td><td>-2.681550</td><td>apicidin        </td><td>A375  </td></tr>\n",
       "\t<tr><td>BG-1003__NEU__trt_cp          </td><td>ISL1 </td><td>-2.279669</td><td>BG-1003         </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BG-1003__NPC__trt_cp          </td><td>ISL1 </td><td>-2.050464</td><td>BG-1003         </td><td>NPC   </td></tr>\n",
       "\t<tr><td>BG-1025__NEU__trt_cp          </td><td>ISL1 </td><td>-2.330200</td><td>BG-1025         </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BG-1025__NPC__trt_cp          </td><td>ISL1 </td><td>-2.107575</td><td>BG-1025         </td><td>NPC   </td></tr>\n",
       "\t<tr><td>BML-257__NEU__trt_cp          </td><td>ISL1 </td><td>-5.686600</td><td>BML-257         </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BML-257__NEU__trt_cp          </td><td>VENTX</td><td>-3.350300</td><td>BML-257         </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BMY-14802__NPC__trt_cp        </td><td>ISL1 </td><td>-2.252357</td><td>BMY-14802       </td><td>NPC   </td></tr>\n",
       "\t<tr><td>BMY-14802__PHH__trt_cp        </td><td>ISL1 </td><td>-2.118578</td><td>BMY-14802       </td><td>PHH   </td></tr>\n",
       "\t<tr><td>BRD-A68274214__NEU__trt_cp    </td><td>ISL1 </td><td>-2.049750</td><td>BRD-A68274214   </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BRD-A68274214__VCAP__trt_cp   </td><td>VENTX</td><td>-2.685372</td><td>BRD-A68274214   </td><td>VCAP  </td></tr>\n",
       "\t<tr><td>BRD-K02223034__A549__trt_cp   </td><td>ISL1 </td><td>-2.238800</td><td>BRD-K02223034   </td><td>A549  </td></tr>\n",
       "\t<tr><td>BRD-K02223034__SKB__trt_cp    </td><td>ISL1 </td><td>-2.220776</td><td>BRD-K02223034   </td><td>SKB   </td></tr>\n",
       "\t<tr><td>BRD-K25731886__A549__trt_cp   </td><td>ISL1 </td><td>-4.073600</td><td>BRD-K25731886   </td><td>A549  </td></tr>\n",
       "\t<tr><td>BRD-K25731886__NEU__trt_cp    </td><td>ISL1 </td><td>-2.935900</td><td>BRD-K25731886   </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BRD-K44893543__NEU__trt_cp    </td><td>HOXC5</td><td>-2.403568</td><td>BRD-K44893543   </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BRD-K44893543__NEU__trt_cp    </td><td>VENTX</td><td>-2.608974</td><td>BRD-K44893543   </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BRD-K66884694__MCF7__trt_cp   </td><td>ISL1 </td><td>-2.475050</td><td>BRD-K66884694   </td><td>MCF7  </td></tr>\n",
       "\t<tr><td>BRD-K66884694__VCAP__trt_cp   </td><td>ISL1 </td><td>-2.011937</td><td>BRD-K66884694   </td><td>VCAP  </td></tr>\n",
       "\t<tr><td>BRD-K98731749__NEU__trt_cp    </td><td>ISL1 </td><td>-3.041465</td><td>BRD-K98731749   </td><td>NEU   </td></tr>\n",
       "\t<tr><td>BRD-K98731749__VCAP__trt_cp   </td><td>VENTX</td><td>-2.255098</td><td>BRD-K98731749   </td><td>VCAP  </td></tr>\n",
       "\t<tr><td>butoconazole__PHH__trt_cp     </td><td>ISL1 </td><td>-2.217050</td><td>butoconazole    </td><td>PHH   </td></tr>\n",
       "\t<tr><td>butoconazole__HCC515__trt_cp  </td><td>VENTX</td><td>-2.043097</td><td>butoconazole    </td><td>HCC515</td></tr>\n",
       "\t<tr><td>cucurbitacin-i__MCF7__trt_cp  </td><td>HOXC5</td><td>-2.504937</td><td>cucurbitacin-i  </td><td>MCF7  </td></tr>\n",
       "\t<tr><td>cucurbitacin-i__MCF7__trt_cp  </td><td>ISL1 </td><td>-2.131572</td><td>cucurbitacin-i  </td><td>MCF7  </td></tr>\n",
       "\t<tr><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td></tr>\n",
       "\t<tr><td>SEW-05685__VCAP__trt_cp             </td><td>VENTX</td><td>-2.412868</td><td>SEW-05685             </td><td>VCAP</td></tr>\n",
       "\t<tr><td>SJ-172550__VCAP__trt_cp             </td><td>VENTX</td><td>-2.893954</td><td>SJ-172550             </td><td>VCAP</td></tr>\n",
       "\t<tr><td>sorafenib__VCAP__trt_cp             </td><td>HOXC5</td><td>-2.387828</td><td>sorafenib             </td><td>VCAP</td></tr>\n",
       "\t<tr><td>SQ-22536__NPC__trt_cp               </td><td>HOXC5</td><td>-2.024650</td><td>SQ-22536              </td><td>NPC </td></tr>\n",
       "\t<tr><td>SR-12813__NEU__trt_cp               </td><td>ISL1 </td><td>-2.061450</td><td>SR-12813              </td><td>NEU </td></tr>\n",
       "\t<tr><td>ST-4029010__NEU__trt_cp             </td><td>HOXC5</td><td>-2.160550</td><td>ST-4029010            </td><td>NEU </td></tr>\n",
       "\t<tr><td>ST-638__HA1E__trt_cp                </td><td>ISL1 </td><td>-2.139165</td><td>ST-638                </td><td>HA1E</td></tr>\n",
       "\t<tr><td>staurosporine__A375__trt_cp         </td><td>ISL1 </td><td>-3.507200</td><td>staurosporine         </td><td>A375</td></tr>\n",
       "\t<tr><td>STK-397047__NEU__trt_cp             </td><td>ISL1 </td><td>-2.067650</td><td>STK-397047            </td><td>NEU </td></tr>\n",
       "\t<tr><td>STOCK1S-03920__MCF7__trt_cp         </td><td>ISL1 </td><td>-2.238906</td><td>STOCK1S-03920         </td><td>MCF7</td></tr>\n",
       "\t<tr><td>temozolomide__NEU__trt_cp           </td><td>ISL1 </td><td>-2.358148</td><td>temozolomide          </td><td>NEU </td></tr>\n",
       "\t<tr><td>teniposide__NPC__trt_cp             </td><td>ISL1 </td><td>-2.629349</td><td>teniposide            </td><td>NPC </td></tr>\n",
       "\t<tr><td>tert-butylhydroquinone__MCF7__trt_cp</td><td>ISL1 </td><td>-3.080953</td><td>tert-butylhydroquinone</td><td>MCF7</td></tr>\n",
       "\t<tr><td>toremifene__MCF7__trt_cp            </td><td>HOXC5</td><td>-2.111762</td><td>toremifene            </td><td>MCF7</td></tr>\n",
       "\t<tr><td>torin-2__PHH__trt_cp                </td><td>ISL1 </td><td>-2.098830</td><td>torin-2               </td><td>PHH </td></tr>\n",
       "\t<tr><td>tranilast__PHH__trt_cp              </td><td>ISL1 </td><td>-3.020363</td><td>tranilast             </td><td>PHH </td></tr>\n",
       "\t<tr><td>treprostinil__PHH__trt_cp           </td><td>VENTX</td><td>-2.756694</td><td>treprostinil          </td><td>PHH </td></tr>\n",
       "\t<tr><td>tributyltin__HA1E__trt_cp           </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin           </td><td>HA1E</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin         </td><td>HA1E</td></tr>\n",
       "\t<tr><td>tubacin__VCAP__trt_cp               </td><td>VENTX</td><td>-3.499640</td><td>tubacin               </td><td>VCAP</td></tr>\n",
       "\t<tr><td>tyrphostin-AG-825__MCF7__trt_cp     </td><td>VENTX</td><td>-2.394913</td><td>tyrphostin-AG-825     </td><td>MCF7</td></tr>\n",
       "\t<tr><td>ubenimex__VCAP__trt_cp              </td><td>ISL1 </td><td>-2.167702</td><td>ubenimex              </td><td>VCAP</td></tr>\n",
       "\t<tr><td>verrucarin-a__NEU__trt_cp           </td><td>HOXC5</td><td>-2.535550</td><td>verrucarin-a          </td><td>NEU </td></tr>\n",
       "\t<tr><td>verteporfin__VCAP__trt_cp           </td><td>VENTX</td><td>-2.372383</td><td>verteporfin           </td><td>VCAP</td></tr>\n",
       "\t<tr><td>vinblastine__PHH__trt_cp            </td><td>ISL1 </td><td>-2.215100</td><td>vinblastine           </td><td>PHH </td></tr>\n",
       "\t<tr><td>WYE-125132__MCF7__trt_cp            </td><td>HOXC5</td><td>-2.019033</td><td>WYE-125132            </td><td>MCF7</td></tr>\n",
       "\t<tr><td>WYE-354__ASC__trt_cp                </td><td>HOXC5</td><td>-2.030976</td><td>WYE-354               </td><td>ASC </td></tr>\n",
       "\t<tr><td>WZ-3105__NPC__trt_cp                </td><td>ISL1 </td><td>-2.444200</td><td>WZ-3105               </td><td>NPC </td></tr>\n",
       "\t<tr><td>YM-155__NPC__trt_cp                 </td><td>ISL1 </td><td>-2.259500</td><td>YM-155                </td><td>NPC </td></tr>\n",
       "\t<tr><td>zoxazolamine__PHH__trt_cp           </td><td>VENTX</td><td>-2.148100</td><td>zoxazolamine          </td><td>PHH </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 326 × 5\n",
       "\\begin{tabular}{lllll}\n",
       " Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
       " <chr> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
       "\\hline\n",
       "\t alpha-tocopherol\\_\\_MCF7\\_\\_trt\\_cp & ISL1  & -2.502400 & alpha-tocopherol & MCF7  \\\\\n",
       "\t alpha-tocopherol\\_\\_PC3\\_\\_trt\\_cp  & ISL1  & -2.310900 & alpha-tocopherol & PC3   \\\\\n",
       "\t anisomycin\\_\\_NEU\\_\\_trt\\_cp        & HOXC5 & -2.530992 & anisomycin       & NEU   \\\\\n",
       "\t anisomycin\\_\\_ASC\\_\\_trt\\_cp        & ISL1  & -2.111786 & anisomycin       & ASC   \\\\\n",
       "\t apicidin\\_\\_HEPG2\\_\\_trt\\_cp        & HOXC5 & -2.335700 & apicidin         & HEPG2 \\\\\n",
       "\t apicidin\\_\\_A375\\_\\_trt\\_cp         & ISL1  & -2.681550 & apicidin         & A375  \\\\\n",
       "\t BG-1003\\_\\_NEU\\_\\_trt\\_cp           & ISL1  & -2.279669 & BG-1003          & NEU   \\\\\n",
       "\t BG-1003\\_\\_NPC\\_\\_trt\\_cp           & ISL1  & -2.050464 & BG-1003          & NPC   \\\\\n",
       "\t BG-1025\\_\\_NEU\\_\\_trt\\_cp           & ISL1  & -2.330200 & BG-1025          & NEU   \\\\\n",
       "\t BG-1025\\_\\_NPC\\_\\_trt\\_cp           & ISL1  & -2.107575 & BG-1025          & NPC   \\\\\n",
       "\t BML-257\\_\\_NEU\\_\\_trt\\_cp           & ISL1  & -5.686600 & BML-257          & NEU   \\\\\n",
       "\t BML-257\\_\\_NEU\\_\\_trt\\_cp           & VENTX & -3.350300 & BML-257          & NEU   \\\\\n",
       "\t BMY-14802\\_\\_NPC\\_\\_trt\\_cp         & ISL1  & -2.252357 & BMY-14802        & NPC   \\\\\n",
       "\t BMY-14802\\_\\_PHH\\_\\_trt\\_cp         & ISL1  & -2.118578 & BMY-14802        & PHH   \\\\\n",
       "\t BRD-A68274214\\_\\_NEU\\_\\_trt\\_cp     & ISL1  & -2.049750 & BRD-A68274214    & NEU   \\\\\n",
       "\t BRD-A68274214\\_\\_VCAP\\_\\_trt\\_cp    & VENTX & -2.685372 & BRD-A68274214    & VCAP  \\\\\n",
       "\t BRD-K02223034\\_\\_A549\\_\\_trt\\_cp    & ISL1  & -2.238800 & BRD-K02223034    & A549  \\\\\n",
       "\t BRD-K02223034\\_\\_SKB\\_\\_trt\\_cp     & ISL1  & -2.220776 & BRD-K02223034    & SKB   \\\\\n",
       "\t BRD-K25731886\\_\\_A549\\_\\_trt\\_cp    & ISL1  & -4.073600 & BRD-K25731886    & A549  \\\\\n",
       "\t BRD-K25731886\\_\\_NEU\\_\\_trt\\_cp     & ISL1  & -2.935900 & BRD-K25731886    & NEU   \\\\\n",
       "\t BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp     & HOXC5 & -2.403568 & BRD-K44893543    & NEU   \\\\\n",
       "\t BRD-K44893543\\_\\_NEU\\_\\_trt\\_cp     & VENTX & -2.608974 & BRD-K44893543    & NEU   \\\\\n",
       "\t BRD-K66884694\\_\\_MCF7\\_\\_trt\\_cp    & ISL1  & -2.475050 & BRD-K66884694    & MCF7  \\\\\n",
       "\t BRD-K66884694\\_\\_VCAP\\_\\_trt\\_cp    & ISL1  & -2.011937 & BRD-K66884694    & VCAP  \\\\\n",
       "\t BRD-K98731749\\_\\_NEU\\_\\_trt\\_cp     & ISL1  & -3.041465 & BRD-K98731749    & NEU   \\\\\n",
       "\t BRD-K98731749\\_\\_VCAP\\_\\_trt\\_cp    & VENTX & -2.255098 & BRD-K98731749    & VCAP  \\\\\n",
       "\t butoconazole\\_\\_PHH\\_\\_trt\\_cp      & ISL1  & -2.217050 & butoconazole     & PHH   \\\\\n",
       "\t butoconazole\\_\\_HCC515\\_\\_trt\\_cp   & VENTX & -2.043097 & butoconazole     & HCC515\\\\\n",
       "\t cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp   & HOXC5 & -2.504937 & cucurbitacin-i   & MCF7  \\\\\n",
       "\t cucurbitacin-i\\_\\_MCF7\\_\\_trt\\_cp   & ISL1  & -2.131572 & cucurbitacin-i   & MCF7  \\\\\n",
       "\t ⋮ & ⋮ & ⋮ & ⋮ & ⋮\\\\\n",
       "\t SEW-05685\\_\\_VCAP\\_\\_trt\\_cp              & VENTX & -2.412868 & SEW-05685              & VCAP\\\\\n",
       "\t SJ-172550\\_\\_VCAP\\_\\_trt\\_cp              & VENTX & -2.893954 & SJ-172550              & VCAP\\\\\n",
       "\t sorafenib\\_\\_VCAP\\_\\_trt\\_cp              & HOXC5 & -2.387828 & sorafenib              & VCAP\\\\\n",
       "\t SQ-22536\\_\\_NPC\\_\\_trt\\_cp                & HOXC5 & -2.024650 & SQ-22536               & NPC \\\\\n",
       "\t SR-12813\\_\\_NEU\\_\\_trt\\_cp                & ISL1  & -2.061450 & SR-12813               & NEU \\\\\n",
       "\t ST-4029010\\_\\_NEU\\_\\_trt\\_cp              & HOXC5 & -2.160550 & ST-4029010             & NEU \\\\\n",
       "\t ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & ISL1  & -2.139165 & ST-638                 & HA1E\\\\\n",
       "\t staurosporine\\_\\_A375\\_\\_trt\\_cp          & ISL1  & -3.507200 & staurosporine          & A375\\\\\n",
       "\t STK-397047\\_\\_NEU\\_\\_trt\\_cp              & ISL1  & -2.067650 & STK-397047             & NEU \\\\\n",
       "\t STOCK1S-03920\\_\\_MCF7\\_\\_trt\\_cp          & ISL1  & -2.238906 & STOCK1S-03920          & MCF7\\\\\n",
       "\t temozolomide\\_\\_NEU\\_\\_trt\\_cp            & ISL1  & -2.358148 & temozolomide           & NEU \\\\\n",
       "\t teniposide\\_\\_NPC\\_\\_trt\\_cp              & ISL1  & -2.629349 & teniposide             & NPC \\\\\n",
       "\t tert-butylhydroquinone\\_\\_MCF7\\_\\_trt\\_cp & ISL1  & -3.080953 & tert-butylhydroquinone & MCF7\\\\\n",
       "\t toremifene\\_\\_MCF7\\_\\_trt\\_cp             & HOXC5 & -2.111762 & toremifene             & MCF7\\\\\n",
       "\t torin-2\\_\\_PHH\\_\\_trt\\_cp                 & ISL1  & -2.098830 & torin-2                & PHH \\\\\n",
       "\t tranilast\\_\\_PHH\\_\\_trt\\_cp               & ISL1  & -3.020363 & tranilast              & PHH \\\\\n",
       "\t treprostinil\\_\\_PHH\\_\\_trt\\_cp            & VENTX & -2.756694 & treprostinil           & PHH \\\\\n",
       "\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & ISL1  & -3.094550 & tributyltin            & HA1E\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.005953 & triphenyl-tin          & HA1E\\\\\n",
       "\t tubacin\\_\\_VCAP\\_\\_trt\\_cp                & VENTX & -3.499640 & tubacin                & VCAP\\\\\n",
       "\t tyrphostin-AG-825\\_\\_MCF7\\_\\_trt\\_cp      & VENTX & -2.394913 & tyrphostin-AG-825      & MCF7\\\\\n",
       "\t ubenimex\\_\\_VCAP\\_\\_trt\\_cp               & ISL1  & -2.167702 & ubenimex               & VCAP\\\\\n",
       "\t verrucarin-a\\_\\_NEU\\_\\_trt\\_cp            & HOXC5 & -2.535550 & verrucarin-a           & NEU \\\\\n",
       "\t verteporfin\\_\\_VCAP\\_\\_trt\\_cp            & VENTX & -2.372383 & verteporfin            & VCAP\\\\\n",
       "\t vinblastine\\_\\_PHH\\_\\_trt\\_cp             & ISL1  & -2.215100 & vinblastine            & PHH \\\\\n",
       "\t WYE-125132\\_\\_MCF7\\_\\_trt\\_cp             & HOXC5 & -2.019033 & WYE-125132             & MCF7\\\\\n",
       "\t WYE-354\\_\\_ASC\\_\\_trt\\_cp                 & HOXC5 & -2.030976 & WYE-354                & ASC \\\\\n",
       "\t WZ-3105\\_\\_NPC\\_\\_trt\\_cp                 & ISL1  & -2.444200 & WZ-3105                & NPC \\\\\n",
       "\t YM-155\\_\\_NPC\\_\\_trt\\_cp                  & ISL1  & -2.259500 & YM-155                 & NPC \\\\\n",
       "\t zoxazolamine\\_\\_PHH\\_\\_trt\\_cp            & VENTX & -2.148100 & zoxazolamine           & PHH \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 326 × 5\n",
       "\n",
       "| Drug &lt;chr&gt; | TF &lt;chr&gt; | ZSCORE &lt;dbl&gt; | Drug.name &lt;fct&gt; | cellLine &lt;chr&gt; |\n",
       "|---|---|---|---|---|\n",
       "| alpha-tocopherol__MCF7__trt_cp | ISL1  | -2.502400 | alpha-tocopherol | MCF7   |\n",
       "| alpha-tocopherol__PC3__trt_cp  | ISL1  | -2.310900 | alpha-tocopherol | PC3    |\n",
       "| anisomycin__NEU__trt_cp        | HOXC5 | -2.530992 | anisomycin       | NEU    |\n",
       "| anisomycin__ASC__trt_cp        | ISL1  | -2.111786 | anisomycin       | ASC    |\n",
       "| apicidin__HEPG2__trt_cp        | HOXC5 | -2.335700 | apicidin         | HEPG2  |\n",
       "| apicidin__A375__trt_cp         | ISL1  | -2.681550 | apicidin         | A375   |\n",
       "| BG-1003__NEU__trt_cp           | ISL1  | -2.279669 | BG-1003          | NEU    |\n",
       "| BG-1003__NPC__trt_cp           | ISL1  | -2.050464 | BG-1003          | NPC    |\n",
       "| BG-1025__NEU__trt_cp           | ISL1  | -2.330200 | BG-1025          | NEU    |\n",
       "| BG-1025__NPC__trt_cp           | ISL1  | -2.107575 | BG-1025          | NPC    |\n",
       "| BML-257__NEU__trt_cp           | ISL1  | -5.686600 | BML-257          | NEU    |\n",
       "| BML-257__NEU__trt_cp           | VENTX | -3.350300 | BML-257          | NEU    |\n",
       "| BMY-14802__NPC__trt_cp         | ISL1  | -2.252357 | BMY-14802        | NPC    |\n",
       "| BMY-14802__PHH__trt_cp         | ISL1  | -2.118578 | BMY-14802        | PHH    |\n",
       "| BRD-A68274214__NEU__trt_cp     | ISL1  | -2.049750 | BRD-A68274214    | NEU    |\n",
       "| BRD-A68274214__VCAP__trt_cp    | VENTX | -2.685372 | BRD-A68274214    | VCAP   |\n",
       "| BRD-K02223034__A549__trt_cp    | ISL1  | -2.238800 | BRD-K02223034    | A549   |\n",
       "| BRD-K02223034__SKB__trt_cp     | ISL1  | -2.220776 | BRD-K02223034    | SKB    |\n",
       "| BRD-K25731886__A549__trt_cp    | ISL1  | -4.073600 | BRD-K25731886    | A549   |\n",
       "| BRD-K25731886__NEU__trt_cp     | ISL1  | -2.935900 | BRD-K25731886    | NEU    |\n",
       "| BRD-K44893543__NEU__trt_cp     | HOXC5 | -2.403568 | BRD-K44893543    | NEU    |\n",
       "| BRD-K44893543__NEU__trt_cp     | VENTX | -2.608974 | BRD-K44893543    | NEU    |\n",
       "| BRD-K66884694__MCF7__trt_cp    | ISL1  | -2.475050 | BRD-K66884694    | MCF7   |\n",
       "| BRD-K66884694__VCAP__trt_cp    | ISL1  | -2.011937 | BRD-K66884694    | VCAP   |\n",
       "| BRD-K98731749__NEU__trt_cp     | ISL1  | -3.041465 | BRD-K98731749    | NEU    |\n",
       "| BRD-K98731749__VCAP__trt_cp    | VENTX | -2.255098 | BRD-K98731749    | VCAP   |\n",
       "| butoconazole__PHH__trt_cp      | ISL1  | -2.217050 | butoconazole     | PHH    |\n",
       "| butoconazole__HCC515__trt_cp   | VENTX | -2.043097 | butoconazole     | HCC515 |\n",
       "| cucurbitacin-i__MCF7__trt_cp   | HOXC5 | -2.504937 | cucurbitacin-i   | MCF7   |\n",
       "| cucurbitacin-i__MCF7__trt_cp   | ISL1  | -2.131572 | cucurbitacin-i   | MCF7   |\n",
       "| ⋮ | ⋮ | ⋮ | ⋮ | ⋮ |\n",
       "| SEW-05685__VCAP__trt_cp              | VENTX | -2.412868 | SEW-05685              | VCAP |\n",
       "| SJ-172550__VCAP__trt_cp              | VENTX | -2.893954 | SJ-172550              | VCAP |\n",
       "| sorafenib__VCAP__trt_cp              | HOXC5 | -2.387828 | sorafenib              | VCAP |\n",
       "| SQ-22536__NPC__trt_cp                | HOXC5 | -2.024650 | SQ-22536               | NPC  |\n",
       "| SR-12813__NEU__trt_cp                | ISL1  | -2.061450 | SR-12813               | NEU  |\n",
       "| ST-4029010__NEU__trt_cp              | HOXC5 | -2.160550 | ST-4029010             | NEU  |\n",
       "| ST-638__HA1E__trt_cp                 | ISL1  | -2.139165 | ST-638                 | HA1E |\n",
       "| staurosporine__A375__trt_cp          | ISL1  | -3.507200 | staurosporine          | A375 |\n",
       "| STK-397047__NEU__trt_cp              | ISL1  | -2.067650 | STK-397047             | NEU  |\n",
       "| STOCK1S-03920__MCF7__trt_cp          | ISL1  | -2.238906 | STOCK1S-03920          | MCF7 |\n",
       "| temozolomide__NEU__trt_cp            | ISL1  | -2.358148 | temozolomide           | NEU  |\n",
       "| teniposide__NPC__trt_cp              | ISL1  | -2.629349 | teniposide             | NPC  |\n",
       "| tert-butylhydroquinone__MCF7__trt_cp | ISL1  | -3.080953 | tert-butylhydroquinone | MCF7 |\n",
       "| toremifene__MCF7__trt_cp             | HOXC5 | -2.111762 | toremifene             | MCF7 |\n",
       "| torin-2__PHH__trt_cp                 | ISL1  | -2.098830 | torin-2                | PHH  |\n",
       "| tranilast__PHH__trt_cp               | ISL1  | -3.020363 | tranilast              | PHH  |\n",
       "| treprostinil__PHH__trt_cp            | VENTX | -2.756694 | treprostinil           | PHH  |\n",
       "| tributyltin__HA1E__trt_cp            | ISL1  | -3.094550 | tributyltin            | HA1E |\n",
       "| triphenyl-tin__HA1E__trt_cp          | ISL1  | -2.005953 | triphenyl-tin          | HA1E |\n",
       "| tubacin__VCAP__trt_cp                | VENTX | -3.499640 | tubacin                | VCAP |\n",
       "| tyrphostin-AG-825__MCF7__trt_cp      | VENTX | -2.394913 | tyrphostin-AG-825      | MCF7 |\n",
       "| ubenimex__VCAP__trt_cp               | ISL1  | -2.167702 | ubenimex               | VCAP |\n",
       "| verrucarin-a__NEU__trt_cp            | HOXC5 | -2.535550 | verrucarin-a           | NEU  |\n",
       "| verteporfin__VCAP__trt_cp            | VENTX | -2.372383 | verteporfin            | VCAP |\n",
       "| vinblastine__PHH__trt_cp             | ISL1  | -2.215100 | vinblastine            | PHH  |\n",
       "| WYE-125132__MCF7__trt_cp             | HOXC5 | -2.019033 | WYE-125132             | MCF7 |\n",
       "| WYE-354__ASC__trt_cp                 | HOXC5 | -2.030976 | WYE-354                | ASC  |\n",
       "| WZ-3105__NPC__trt_cp                 | ISL1  | -2.444200 | WZ-3105                | NPC  |\n",
       "| YM-155__NPC__trt_cp                  | ISL1  | -2.259500 | YM-155                 | NPC  |\n",
       "| zoxazolamine__PHH__trt_cp            | VENTX | -2.148100 | zoxazolamine           | PHH  |\n",
       "\n"
      ],
      "text/plain": [
       "    Drug                                 TF    ZSCORE    Drug.name             \n",
       "1   alpha-tocopherol__MCF7__trt_cp       ISL1  -2.502400 alpha-tocopherol      \n",
       "2   alpha-tocopherol__PC3__trt_cp        ISL1  -2.310900 alpha-tocopherol      \n",
       "3   anisomycin__NEU__trt_cp              HOXC5 -2.530992 anisomycin            \n",
       "4   anisomycin__ASC__trt_cp              ISL1  -2.111786 anisomycin            \n",
       "5   apicidin__HEPG2__trt_cp              HOXC5 -2.335700 apicidin              \n",
       "6   apicidin__A375__trt_cp               ISL1  -2.681550 apicidin              \n",
       "7   BG-1003__NEU__trt_cp                 ISL1  -2.279669 BG-1003               \n",
       "8   BG-1003__NPC__trt_cp                 ISL1  -2.050464 BG-1003               \n",
       "9   BG-1025__NEU__trt_cp                 ISL1  -2.330200 BG-1025               \n",
       "10  BG-1025__NPC__trt_cp                 ISL1  -2.107575 BG-1025               \n",
       "11  BML-257__NEU__trt_cp                 ISL1  -5.686600 BML-257               \n",
       "12  BML-257__NEU__trt_cp                 VENTX -3.350300 BML-257               \n",
       "13  BMY-14802__NPC__trt_cp               ISL1  -2.252357 BMY-14802             \n",
       "14  BMY-14802__PHH__trt_cp               ISL1  -2.118578 BMY-14802             \n",
       "15  BRD-A68274214__NEU__trt_cp           ISL1  -2.049750 BRD-A68274214         \n",
       "16  BRD-A68274214__VCAP__trt_cp          VENTX -2.685372 BRD-A68274214         \n",
       "17  BRD-K02223034__A549__trt_cp          ISL1  -2.238800 BRD-K02223034         \n",
       "18  BRD-K02223034__SKB__trt_cp           ISL1  -2.220776 BRD-K02223034         \n",
       "19  BRD-K25731886__A549__trt_cp          ISL1  -4.073600 BRD-K25731886         \n",
       "20  BRD-K25731886__NEU__trt_cp           ISL1  -2.935900 BRD-K25731886         \n",
       "21  BRD-K44893543__NEU__trt_cp           HOXC5 -2.403568 BRD-K44893543         \n",
       "22  BRD-K44893543__NEU__trt_cp           VENTX -2.608974 BRD-K44893543         \n",
       "23  BRD-K66884694__MCF7__trt_cp          ISL1  -2.475050 BRD-K66884694         \n",
       "24  BRD-K66884694__VCAP__trt_cp          ISL1  -2.011937 BRD-K66884694         \n",
       "25  BRD-K98731749__NEU__trt_cp           ISL1  -3.041465 BRD-K98731749         \n",
       "26  BRD-K98731749__VCAP__trt_cp          VENTX -2.255098 BRD-K98731749         \n",
       "27  butoconazole__PHH__trt_cp            ISL1  -2.217050 butoconazole          \n",
       "28  butoconazole__HCC515__trt_cp         VENTX -2.043097 butoconazole          \n",
       "29  cucurbitacin-i__MCF7__trt_cp         HOXC5 -2.504937 cucurbitacin-i        \n",
       "30  cucurbitacin-i__MCF7__trt_cp         ISL1  -2.131572 cucurbitacin-i        \n",
       "⋮   ⋮                                    ⋮     ⋮         ⋮                     \n",
       "297 SEW-05685__VCAP__trt_cp              VENTX -2.412868 SEW-05685             \n",
       "298 SJ-172550__VCAP__trt_cp              VENTX -2.893954 SJ-172550             \n",
       "299 sorafenib__VCAP__trt_cp              HOXC5 -2.387828 sorafenib             \n",
       "300 SQ-22536__NPC__trt_cp                HOXC5 -2.024650 SQ-22536              \n",
       "301 SR-12813__NEU__trt_cp                ISL1  -2.061450 SR-12813              \n",
       "302 ST-4029010__NEU__trt_cp              HOXC5 -2.160550 ST-4029010            \n",
       "303 ST-638__HA1E__trt_cp                 ISL1  -2.139165 ST-638                \n",
       "304 staurosporine__A375__trt_cp          ISL1  -3.507200 staurosporine         \n",
       "305 STK-397047__NEU__trt_cp              ISL1  -2.067650 STK-397047            \n",
       "306 STOCK1S-03920__MCF7__trt_cp          ISL1  -2.238906 STOCK1S-03920         \n",
       "307 temozolomide__NEU__trt_cp            ISL1  -2.358148 temozolomide          \n",
       "308 teniposide__NPC__trt_cp              ISL1  -2.629349 teniposide            \n",
       "309 tert-butylhydroquinone__MCF7__trt_cp ISL1  -3.080953 tert-butylhydroquinone\n",
       "310 toremifene__MCF7__trt_cp             HOXC5 -2.111762 toremifene            \n",
       "311 torin-2__PHH__trt_cp                 ISL1  -2.098830 torin-2               \n",
       "312 tranilast__PHH__trt_cp               ISL1  -3.020363 tranilast             \n",
       "313 treprostinil__PHH__trt_cp            VENTX -2.756694 treprostinil          \n",
       "314 tributyltin__HA1E__trt_cp            ISL1  -3.094550 tributyltin           \n",
       "315 triphenyl-tin__HA1E__trt_cp          ISL1  -2.005953 triphenyl-tin         \n",
       "316 tubacin__VCAP__trt_cp                VENTX -3.499640 tubacin               \n",
       "317 tyrphostin-AG-825__MCF7__trt_cp      VENTX -2.394913 tyrphostin-AG-825     \n",
       "318 ubenimex__VCAP__trt_cp               ISL1  -2.167702 ubenimex              \n",
       "319 verrucarin-a__NEU__trt_cp            HOXC5 -2.535550 verrucarin-a          \n",
       "320 verteporfin__VCAP__trt_cp            VENTX -2.372383 verteporfin           \n",
       "321 vinblastine__PHH__trt_cp             ISL1  -2.215100 vinblastine           \n",
       "322 WYE-125132__MCF7__trt_cp             HOXC5 -2.019033 WYE-125132            \n",
       "323 WYE-354__ASC__trt_cp                 HOXC5 -2.030976 WYE-354               \n",
       "324 WZ-3105__NPC__trt_cp                 ISL1  -2.444200 WZ-3105               \n",
       "325 YM-155__NPC__trt_cp                  ISL1  -2.259500 YM-155                \n",
       "326 zoxazolamine__PHH__trt_cp            VENTX -2.148100 zoxazolamine          \n",
       "    cellLine\n",
       "1   MCF7    \n",
       "2   PC3     \n",
       "3   NEU     \n",
       "4   ASC     \n",
       "5   HEPG2   \n",
       "6   A375    \n",
       "7   NEU     \n",
       "8   NPC     \n",
       "9   NEU     \n",
       "10  NPC     \n",
       "11  NEU     \n",
       "12  NEU     \n",
       "13  NPC     \n",
       "14  PHH     \n",
       "15  NEU     \n",
       "16  VCAP    \n",
       "17  A549    \n",
       "18  SKB     \n",
       "19  A549    \n",
       "20  NEU     \n",
       "21  NEU     \n",
       "22  NEU     \n",
       "23  MCF7    \n",
       "24  VCAP    \n",
       "25  NEU     \n",
       "26  VCAP    \n",
       "27  PHH     \n",
       "28  HCC515  \n",
       "29  MCF7    \n",
       "30  MCF7    \n",
       "⋮   ⋮       \n",
       "297 VCAP    \n",
       "298 VCAP    \n",
       "299 VCAP    \n",
       "300 NPC     \n",
       "301 NEU     \n",
       "302 NEU     \n",
       "303 HA1E    \n",
       "304 A375    \n",
       "305 NEU     \n",
       "306 MCF7    \n",
       "307 NEU     \n",
       "308 NPC     \n",
       "309 MCF7    \n",
       "310 MCF7    \n",
       "311 PHH     \n",
       "312 PHH     \n",
       "313 PHH     \n",
       "314 HA1E    \n",
       "315 HA1E    \n",
       "316 VCAP    \n",
       "317 MCF7    \n",
       "318 VCAP    \n",
       "319 NEU     \n",
       "320 VCAP    \n",
       "321 PHH     \n",
       "322 MCF7    \n",
       "323 ASC     \n",
       "324 NPC     \n",
       "325 NPC     \n",
       "326 PHH     "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "####output \n",
    "library (plyr)\n",
    "drug.result <- ldply (drug.lists, data.frame)\n",
    "drug.result <- drug.result[,c(2,1,3)]\n",
    "colnames(drug.result) <- c(\"Drug\", \"TF\", \"ZSCORE\")\n",
    "library(writexl)\n",
    "drug.result$Drug.name <- gsub(\"__.*\", \"\", drug.result$Drug)\n",
    "drug.result$cellLine <- gsub(\"__trt_cp\", \"\", drug.result$Drug)\n",
    "drug.result$cellLine <- gsub(\".*__\", \"\", drug.result$cellLine)\n",
    "drug.idx <- sort(table(drug.result$Drug.name),decreasing = T)\n",
    "drug.result$Drug.name <- factor(drug.result$Drug.name, levels = names(drug.idx))\n",
    "drug.result <- arrange(drug.result, Drug.name, TF, Drug)\n",
    "write_xlsx(drug.result, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.negative.drug.result.xlsx\")\n",
    "drug.result"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "d84ea99d-1cdd-492b-a2c7-8f7f86f2ac1b",
   "metadata": {},
   "source": [
    "##### 查看Lincs中的药物信息和细胞系信息"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "id": "a23c2274-8430-4715-9f07-385ba9e74767",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:38.342470Z",
     "iopub.status.busy": "2021-09-23T06:22:38.338912Z",
     "iopub.status.idle": "2021-09-23T06:22:50.668557Z",
     "shell.execute_reply": "2021-09-23T06:22:50.667164Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 6 × 35</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>bead_batch</th><th scope=col>nearest_dose</th><th scope=col>pert_dose</th><th scope=col>pert_dose_unit</th><th scope=col>pert_idose</th><th scope=col>pert_itime</th><th scope=col>pert_time</th><th scope=col>pert_time_unit</th><th scope=col>cell_mfc_name</th><th scope=col>pert_mfc_id</th><th scope=col>⋯</th><th scope=col>sig_id</th><th scope=col>pert_type</th><th scope=col>cell_iname</th><th scope=col>det_wells</th><th scope=col>det_plates</th><th scope=col>distil_ids</th><th scope=col>build_name</th><th scope=col>project_code</th><th scope=col>cmap_name</th><th scope=col>is_ncs_exemplar</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>⋯</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;lgl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;int&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>1</th><td>b17</td><td>  NA</td><td>100.0</td><td>ug/ml</td><td>100 ug/ml</td><td>336 h</td><td>336</td><td>h</td><td>N8   </td><td>BRD-U44432129</td><td>⋯</td><td>MET001_N8_XH:BRD-U44432129:100:336 </td><td>trt_cp</td><td>NAMEC8</td><td>H05|H06|H07|H08</td><td>MET001_N8_XH_X1_B17   </td><td>MET001_N8_XH_X1_B17:H05|MET001_N8_XH_X1_B17:H06|MET001_N8_XH_X1_B17:H07|MET001_N8_XH_X1_B17:H08</td><td>NA</td><td>MET</td><td>BRD-U44432129</td><td>0</td></tr>\n",
       "\t<tr><th scope=row>2</th><td>b15</td><td>10.0</td><td> 10.0</td><td>uM   </td><td>10 uM    </td><td>3 h  </td><td>  3</td><td>h</td><td>A549 </td><td>BRD-K81418486</td><td>⋯</td><td>ABY001_A549_XH:BRD-K81418486:10:3  </td><td>trt_cp</td><td>A549  </td><td>L04|L08|L12    </td><td>ABY001_A549_XH_X1_B15 </td><td>ABY001_A549_XH_X1_B15:L04|ABY001_A549_XH_X1_B15:L08|ABY001_A549_XH_X1_B15:L12                  </td><td>NA</td><td>ABY</td><td>vorinostat   </td><td>0</td></tr>\n",
       "\t<tr><th scope=row>3</th><td>b15</td><td> 2.5</td><td>  2.5</td><td>uM   </td><td>2.5 uM   </td><td>24 h </td><td> 24</td><td>h</td><td>HT29 </td><td>BRD-K70511574</td><td>⋯</td><td>ABY001_HT29_XH:BRD-K70511574:2.5:24</td><td>trt_cp</td><td>HT29  </td><td>E18|E22        </td><td>ABY001_HT29_XH_X1_B15 </td><td>ABY001_HT29_XH_X1_B15:E18|ABY001_HT29_XH_X1_B15:E22                                            </td><td>NA</td><td>ABY</td><td>HMN-214      </td><td>0</td></tr>\n",
       "\t<tr><th scope=row>4</th><td>b18</td><td>10.0</td><td> 10.0</td><td>uM   </td><td>10 uM    </td><td>3 h  </td><td>  3</td><td>h</td><td>HME1 </td><td>BRD-K81418486</td><td>⋯</td><td>LTC002_HME1_3H:BRD-K81418486:10    </td><td>trt_cp</td><td>HME1  </td><td>F19            </td><td>LTC002_HME1_3H_X1_B18 </td><td>LTC002_HME1_3H_X1_B18:F19                                                                      </td><td>NA</td><td>LTC</td><td>vorinostat   </td><td>0</td></tr>\n",
       "\t<tr><th scope=row>5</th><td>b15</td><td>10.0</td><td> 10.0</td><td>uM   </td><td>10 uM    </td><td>3 h  </td><td>  3</td><td>h</td><td>H1975</td><td>BRD-A61304759</td><td>⋯</td><td>ABY001_H1975_XH:BRD-A61304759:10:3 </td><td>trt_cp</td><td>H1975 </td><td>P01|P05|P09    </td><td>ABY001_H1975_XH_X1_B15</td><td>ABY001_H1975_XH_X1_B15:P01|ABY001_H1975_XH_X1_B15:P05|ABY001_H1975_XH_X1_B15:P09               </td><td>NA</td><td>ABY</td><td>tanespimycin </td><td>0</td></tr>\n",
       "\t<tr><th scope=row>6</th><td>b15</td><td>10.0</td><td> 10.0</td><td>uM   </td><td>10 uM    </td><td>24 h </td><td> 24</td><td>h</td><td>H1975</td><td>BRD-K85606544</td><td>⋯</td><td>ABY001_H1975_XH:BRD-K85606544:10:24</td><td>trt_cp</td><td>H1975 </td><td>A15|A19|A23    </td><td>ABY001_H1975_XH_X1_B15</td><td>ABY001_H1975_XH_X1_B15:A15|ABY001_H1975_XH_X1_B15:A19|ABY001_H1975_XH_X1_B15:A23               </td><td>NA</td><td>ABY</td><td>neratinib    </td><td>0</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 6 × 35\n",
       "\\begin{tabular}{r|lllllllllllllllllllll}\n",
       "  & bead\\_batch & nearest\\_dose & pert\\_dose & pert\\_dose\\_unit & pert\\_idose & pert\\_itime & pert\\_time & pert\\_time\\_unit & cell\\_mfc\\_name & pert\\_mfc\\_id & ⋯ & sig\\_id & pert\\_type & cell\\_iname & det\\_wells & det\\_plates & distil\\_ids & build\\_name & project\\_code & cmap\\_name & is\\_ncs\\_exemplar\\\\\n",
       "  & <chr> & <dbl> & <dbl> & <chr> & <chr> & <chr> & <dbl> & <chr> & <chr> & <chr> & ⋯ & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <lgl> & <chr> & <chr> & <int>\\\\\n",
       "\\hline\n",
       "\t1 & b17 &   NA & 100.0 & ug/ml & 100 ug/ml & 336 h & 336 & h & N8    & BRD-U44432129 & ⋯ & MET001\\_N8\\_XH:BRD-U44432129:100:336  & trt\\_cp & NAMEC8 & H05\\textbar{}H06\\textbar{}H07\\textbar{}H08 & MET001\\_N8\\_XH\\_X1\\_B17    & MET001\\_N8\\_XH\\_X1\\_B17:H05\\textbar{}MET001\\_N8\\_XH\\_X1\\_B17:H06\\textbar{}MET001\\_N8\\_XH\\_X1\\_B17:H07\\textbar{}MET001\\_N8\\_XH\\_X1\\_B17:H08 & NA & MET & BRD-U44432129 & 0\\\\\n",
       "\t2 & b15 & 10.0 &  10.0 & uM    & 10 uM     & 3 h   &   3 & h & A549  & BRD-K81418486 & ⋯ & ABY001\\_A549\\_XH:BRD-K81418486:10:3   & trt\\_cp & A549   & L04\\textbar{}L08\\textbar{}L12     & ABY001\\_A549\\_XH\\_X1\\_B15  & ABY001\\_A549\\_XH\\_X1\\_B15:L04\\textbar{}ABY001\\_A549\\_XH\\_X1\\_B15:L08\\textbar{}ABY001\\_A549\\_XH\\_X1\\_B15:L12                   & NA & ABY & vorinostat    & 0\\\\\n",
       "\t3 & b15 &  2.5 &   2.5 & uM    & 2.5 uM    & 24 h  &  24 & h & HT29  & BRD-K70511574 & ⋯ & ABY001\\_HT29\\_XH:BRD-K70511574:2.5:24 & trt\\_cp & HT29   & E18\\textbar{}E22         & ABY001\\_HT29\\_XH\\_X1\\_B15  & ABY001\\_HT29\\_XH\\_X1\\_B15:E18\\textbar{}ABY001\\_HT29\\_XH\\_X1\\_B15:E22                                             & NA & ABY & HMN-214       & 0\\\\\n",
       "\t4 & b18 & 10.0 &  10.0 & uM    & 10 uM     & 3 h   &   3 & h & HME1  & BRD-K81418486 & ⋯ & LTC002\\_HME1\\_3H:BRD-K81418486:10     & trt\\_cp & HME1   & F19             & LTC002\\_HME1\\_3H\\_X1\\_B18  & LTC002\\_HME1\\_3H\\_X1\\_B18:F19                                                                       & NA & LTC & vorinostat    & 0\\\\\n",
       "\t5 & b15 & 10.0 &  10.0 & uM    & 10 uM     & 3 h   &   3 & h & H1975 & BRD-A61304759 & ⋯ & ABY001\\_H1975\\_XH:BRD-A61304759:10:3  & trt\\_cp & H1975  & P01\\textbar{}P05\\textbar{}P09     & ABY001\\_H1975\\_XH\\_X1\\_B15 & ABY001\\_H1975\\_XH\\_X1\\_B15:P01\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:P05\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:P09                & NA & ABY & tanespimycin  & 0\\\\\n",
       "\t6 & b15 & 10.0 &  10.0 & uM    & 10 uM     & 24 h  &  24 & h & H1975 & BRD-K85606544 & ⋯ & ABY001\\_H1975\\_XH:BRD-K85606544:10:24 & trt\\_cp & H1975  & A15\\textbar{}A19\\textbar{}A23     & ABY001\\_H1975\\_XH\\_X1\\_B15 & ABY001\\_H1975\\_XH\\_X1\\_B15:A15\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:A19\\textbar{}ABY001\\_H1975\\_XH\\_X1\\_B15:A23                & NA & ABY & neratinib     & 0\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 6 × 35\n",
       "\n",
       "| <!--/--> | bead_batch &lt;chr&gt; | nearest_dose &lt;dbl&gt; | pert_dose &lt;dbl&gt; | pert_dose_unit &lt;chr&gt; | pert_idose &lt;chr&gt; | pert_itime &lt;chr&gt; | pert_time &lt;dbl&gt; | pert_time_unit &lt;chr&gt; | cell_mfc_name &lt;chr&gt; | pert_mfc_id &lt;chr&gt; | ⋯ ⋯ | sig_id &lt;chr&gt; | pert_type &lt;chr&gt; | cell_iname &lt;chr&gt; | det_wells &lt;chr&gt; | det_plates &lt;chr&gt; | distil_ids &lt;chr&gt; | build_name &lt;lgl&gt; | project_code &lt;chr&gt; | cmap_name &lt;chr&gt; | is_ncs_exemplar &lt;int&gt; |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| 1 | b17 |   NA | 100.0 | ug/ml | 100 ug/ml | 336 h | 336 | h | N8    | BRD-U44432129 | ⋯ | MET001_N8_XH:BRD-U44432129:100:336  | trt_cp | NAMEC8 | H05|H06|H07|H08 | MET001_N8_XH_X1_B17    | MET001_N8_XH_X1_B17:H05|MET001_N8_XH_X1_B17:H06|MET001_N8_XH_X1_B17:H07|MET001_N8_XH_X1_B17:H08 | NA | MET | BRD-U44432129 | 0 |\n",
       "| 2 | b15 | 10.0 |  10.0 | uM    | 10 uM     | 3 h   |   3 | h | A549  | BRD-K81418486 | ⋯ | ABY001_A549_XH:BRD-K81418486:10:3   | trt_cp | A549   | L04|L08|L12     | ABY001_A549_XH_X1_B15  | ABY001_A549_XH_X1_B15:L04|ABY001_A549_XH_X1_B15:L08|ABY001_A549_XH_X1_B15:L12                   | NA | ABY | vorinostat    | 0 |\n",
       "| 3 | b15 |  2.5 |   2.5 | uM    | 2.5 uM    | 24 h  |  24 | h | HT29  | BRD-K70511574 | ⋯ | ABY001_HT29_XH:BRD-K70511574:2.5:24 | trt_cp | HT29   | E18|E22         | ABY001_HT29_XH_X1_B15  | ABY001_HT29_XH_X1_B15:E18|ABY001_HT29_XH_X1_B15:E22                                             | NA | ABY | HMN-214       | 0 |\n",
       "| 4 | b18 | 10.0 |  10.0 | uM    | 10 uM     | 3 h   |   3 | h | HME1  | BRD-K81418486 | ⋯ | LTC002_HME1_3H:BRD-K81418486:10     | trt_cp | HME1   | F19             | LTC002_HME1_3H_X1_B18  | LTC002_HME1_3H_X1_B18:F19                                                                       | NA | LTC | vorinostat    | 0 |\n",
       "| 5 | b15 | 10.0 |  10.0 | uM    | 10 uM     | 3 h   |   3 | h | H1975 | BRD-A61304759 | ⋯ | ABY001_H1975_XH:BRD-A61304759:10:3  | trt_cp | H1975  | P01|P05|P09     | ABY001_H1975_XH_X1_B15 | ABY001_H1975_XH_X1_B15:P01|ABY001_H1975_XH_X1_B15:P05|ABY001_H1975_XH_X1_B15:P09                | NA | ABY | tanespimycin  | 0 |\n",
       "| 6 | b15 | 10.0 |  10.0 | uM    | 10 uM     | 24 h  |  24 | h | H1975 | BRD-K85606544 | ⋯ | ABY001_H1975_XH:BRD-K85606544:10:24 | trt_cp | H1975  | A15|A19|A23     | ABY001_H1975_XH_X1_B15 | ABY001_H1975_XH_X1_B15:A15|ABY001_H1975_XH_X1_B15:A19|ABY001_H1975_XH_X1_B15:A23                | NA | ABY | neratinib     | 0 |\n",
       "\n"
      ],
      "text/plain": [
       "  bead_batch nearest_dose pert_dose pert_dose_unit pert_idose pert_itime\n",
       "1 b17          NA         100.0     ug/ml          100 ug/ml  336 h     \n",
       "2 b15        10.0          10.0     uM             10 uM      3 h       \n",
       "3 b15         2.5           2.5     uM             2.5 uM     24 h      \n",
       "4 b18        10.0          10.0     uM             10 uM      3 h       \n",
       "5 b15        10.0          10.0     uM             10 uM      3 h       \n",
       "6 b15        10.0          10.0     uM             10 uM      24 h      \n",
       "  pert_time pert_time_unit cell_mfc_name pert_mfc_id   ⋯\n",
       "1 336       h              N8            BRD-U44432129 ⋯\n",
       "2   3       h              A549          BRD-K81418486 ⋯\n",
       "3  24       h              HT29          BRD-K70511574 ⋯\n",
       "4   3       h              HME1          BRD-K81418486 ⋯\n",
       "5   3       h              H1975         BRD-A61304759 ⋯\n",
       "6  24       h              H1975         BRD-K85606544 ⋯\n",
       "  sig_id                              pert_type cell_iname det_wells      \n",
       "1 MET001_N8_XH:BRD-U44432129:100:336  trt_cp    NAMEC8     H05|H06|H07|H08\n",
       "2 ABY001_A549_XH:BRD-K81418486:10:3   trt_cp    A549       L04|L08|L12    \n",
       "3 ABY001_HT29_XH:BRD-K70511574:2.5:24 trt_cp    HT29       E18|E22        \n",
       "4 LTC002_HME1_3H:BRD-K81418486:10     trt_cp    HME1       F19            \n",
       "5 ABY001_H1975_XH:BRD-A61304759:10:3  trt_cp    H1975      P01|P05|P09    \n",
       "6 ABY001_H1975_XH:BRD-K85606544:10:24 trt_cp    H1975      A15|A19|A23    \n",
       "  det_plates            \n",
       "1 MET001_N8_XH_X1_B17   \n",
       "2 ABY001_A549_XH_X1_B15 \n",
       "3 ABY001_HT29_XH_X1_B15 \n",
       "4 LTC002_HME1_3H_X1_B18 \n",
       "5 ABY001_H1975_XH_X1_B15\n",
       "6 ABY001_H1975_XH_X1_B15\n",
       "  distil_ids                                                                                     \n",
       "1 MET001_N8_XH_X1_B17:H05|MET001_N8_XH_X1_B17:H06|MET001_N8_XH_X1_B17:H07|MET001_N8_XH_X1_B17:H08\n",
       "2 ABY001_A549_XH_X1_B15:L04|ABY001_A549_XH_X1_B15:L08|ABY001_A549_XH_X1_B15:L12                  \n",
       "3 ABY001_HT29_XH_X1_B15:E18|ABY001_HT29_XH_X1_B15:E22                                            \n",
       "4 LTC002_HME1_3H_X1_B18:F19                                                                      \n",
       "5 ABY001_H1975_XH_X1_B15:P01|ABY001_H1975_XH_X1_B15:P05|ABY001_H1975_XH_X1_B15:P09               \n",
       "6 ABY001_H1975_XH_X1_B15:A15|ABY001_H1975_XH_X1_B15:A19|ABY001_H1975_XH_X1_B15:A23               \n",
       "  build_name project_code cmap_name     is_ncs_exemplar\n",
       "1 NA         MET          BRD-U44432129 0              \n",
       "2 NA         ABY          vorinostat    0              \n",
       "3 NA         ABY          HMN-214       0              \n",
       "4 NA         LTC          vorinostat    0              \n",
       "5 NA         ABY          tanespimycin  0              \n",
       "6 NA         ABY          neratinib     0              "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "####drug information\n",
    "siginfo_beta <- read.table(file = \"siginfo_beta.txt\", header = T, stringsAsFactors = F, sep = \"\\t\")\n",
    "head(siginfo_beta)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "id": "32fd238a-fb78-4b15-bdfa-e401de3ff7eb",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:55.046444Z",
     "iopub.status.busy": "2021-09-23T06:22:55.041761Z",
     "iopub.status.idle": "2021-09-23T06:22:55.068934Z",
     "shell.execute_reply": "2021-09-23T06:22:55.067514Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
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       ".list-inline>li:not(:last-child)::after {content: \"\\00b7\"; padding: 0 .5ex}\n",
       "</style>\n",
       "<ol class=list-inline><li>'1HAE'</li><li>'AALE'</li><li>'AG06263_2'</li><li>'AG06840_A'</li><li>'AG078N1_1'</li><li>'C42'</li><li>'CD34'</li><li>'HAP1'</li><li>'HEK293T'</li><li>'HIMG001'</li><li>'HIMG002'</li><li>'HME'</li><li>'HMELZ'</li><li>'HPTEC'</li><li>'HS27A'</li><li>'HUES3'</li><li>'HUH751'</li><li>'HUVEC'</li><li>'IPS-15-2'</li><li>'IPS-3'</li><li>'IPS-ND34732'</li><li>'LHSAR'</li><li>'MCH58'</li><li>'MCLF0067SZ'</li><li>'MCLF015CN'</li><li>'MCLF022CN'</li><li>'MCLF027CN'</li><li>'MCLF033SZ'</li><li>'MCLF035SZ'</li><li>'MCLF037SZ'</li><li>'MCLF040SZ'</li><li>'MCLF051CN'</li><li>'MCLF054CN'</li><li>'MCLF056CN'</li><li>'MCLF076SZ'</li><li>'MCLF100SZ'</li><li>'MCLF117SZ'</li><li>'MCLF123SZ'</li><li>'MCLF126CN'</li><li>'MCLF130CN'</li><li>'MCLF135CN'</li><li>'MCLF137CN'</li><li>'MCLF141SZ'</li><li>'MCLF162SZ'</li><li>'MICROGLIA-PSEN1'</li><li>'MNEU'</li><li>'NAMEC8'</li><li>'ND34732_7'</li><li>'NKDBA'</li><li>'P1A82'</li><li>'P2X2B2'</li><li>'SKB'</li><li>'WA09'</li><li>'XC.500'</li><li>'XC.L10'</li><li>'XC.L100'</li><li>'XC.P026'</li><li>'XC.P031'</li><li>'XC.P033'</li><li>'XC.P091'</li><li>'XC.P092'</li><li>'XC.P901'</li><li>'XC.P904'</li><li>'XC.P905'</li><li>'XC.P906'</li><li>'XC.P907'</li><li>'XC.P908'</li><li>'XC.P909'</li><li>'XC.P910'</li><li>'XC.P911'</li><li>'XC.P912'</li><li>'XC.P914'</li><li>'XC.P915'</li><li>'XC.P922'</li><li>'XC.P930'</li><li>'XC.P931'</li><li>'XC.P932'</li><li>'XC.P933'</li><li>'XC.P934'</li><li>'XC.P935'</li><li>'XC.P936'</li><li>'XC.R10'</li><li>'HME1'</li><li>'BJAB'</li><li>'HBL1'</li><li>'OCILY10'</li><li>'TMD8'</li><li>'TC32'</li><li>'H1299'</li><li>'H1975'</li><li>'HCC515'</li><li>'SALE'</li><li>'SHSY5Y'</li><li>'22RV1'</li><li>'HEC1A'</li><li>'NL20'</li><li>'PHH'</li><li>'HA1E'</li><li>'HEK293'</li><li>'HEKTE'</li><li>'NEU'</li><li>'NPC'</li><li>'ASC'</li><li>'U266B1'</li><li>'HL60'</li><li>'K562'</li><li>'TF1'</li><li>'THP1'</li><li>'MINO'</li><li>'U937'</li><li>'A673'</li><li>'SKES1'</li><li>'U2OS'</li><li>'A549'</li><li>'HCC827'</li><li>'NCIH1437'</li><li>'NCIH1563'</li><li>'NCIH1573'</li><li>'NCIH1694'</li><li>'NCIH1781'</li><li>'NCIH1836'</li><li>'NCIH1975'</li><li>'NCIH2073'</li><li>'NCIH2110'</li><li>'NCIH2172'</li><li>'NCIH596'</li><li>'NCIH838'</li><li>'NCIH841'</li><li>'SKLU1'</li><li>'A375'</li><li>'SH4'</li><li>'SKMEL1'</li><li>'SKMEL28'</li><li>'SKMEL3'</li><li>'SKMEL5'</li><li>'LN229'</li><li>'DLD1'</li><li>'HCT116'</li><li>'HT29'</li><li>'LOVO'</li><li>'NCIH508'</li><li>'NCIH716'</li><li>'RKO'</li><li>'SW480'</li><li>'SW620'</li><li>'SW948'</li><li>'HEPG2'</li><li>'BT20'</li><li>'BT474'</li><li>'HS578T'</li><li>'MCF10A'</li><li>'MCF7'</li><li>'MDAMB231'</li><li>'MDAMB468'</li><li>'SKBR3'</li><li>'T47D'</li><li>'ZR751'</li><li>'G401'</li><li>'SKNSH'</li><li>'5637'</li><li>'J82'</li><li>'AGS'</li><li>'ES2'</li><li>'HELA'</li><li>'DU145'</li><li>'PC3'</li><li>'RWPE1'</li><li>'VCAP'</li><li>'A204'</li><li>'AN3CA'</li><li>'TOV112D'</li><li>'WI38'</li><li>'JURKAT'</li><li>'NALM6'</li><li>'PL21'</li><li>'OCILY19'</li><li>'SUDHL4'</li><li>'WSUDLCL2'</li><li>'BEN'</li><li>'DV90'</li><li>'HCC15'</li><li>'HCC44'</li><li>'IGR37'</li><li>'MELHO'</li><li>'CL34'</li><li>'BC3C'</li><li>'CAL29'</li><li>'VMCUB1'</li><li>'EFO27'</li><li>'LNCAP'</li><li>'YAPC'</li><li>'MFE319'</li><li>'OC314'</li><li>'OC316'</li><li>'HFL1'</li><li>'IMR90'</li><li>'HCC1588'</li><li>'HCC95'</li><li>'SNU1040'</li><li>'SNU407'</li><li>'SNUC4'</li><li>'SNUC5'</li><li>'CORL23'</li><li>'GP2D'</li><li>'HT115'</li><li>'MDST8'</li><li>'COV434'</li><li>'COV644'</li><li>'OAW28'</li><li>'OV7'</li><li>'BICR6'</li><li>'KMS34'</li><li>'NOMO1'</li><li>'SKM1'</li><li>'U251MG'</li><li>'YH13'</li><li>'HUH7'</li><li>'JHH5'</li><li>'JHH7'</li><li>'IM95'</li><li>'MKN45'</li><li>'OVTOKO'</li><li>'RMGI'</li><li>'RMUGS'</li><li>'TYKNU'</li><li>'HEC108'</li><li>'HEC151'</li><li>'HEC251'</li><li>'HEC265'</li><li>'SNGM'</li><li>'SKL'</li><li>'T3M10'</li><li>'CJM'</li><li>'GI1'</li><li>'CW2'</li><li>'RCC10RGB'</li><li>'OVK18'</li><li>'JHUEM2'</li><li>'OVCAR8'</li><li>'OCILY3'</li></ol>\n"
      ],
      "text/latex": [
       "\\begin{enumerate*}\n",
       "\\item '1HAE'\n",
       "\\item 'AALE'\n",
       "\\item 'AG06263\\_2'\n",
       "\\item 'AG06840\\_A'\n",
       "\\item 'AG078N1\\_1'\n",
       "\\item 'C42'\n",
       "\\item 'CD34'\n",
       "\\item 'HAP1'\n",
       "\\item 'HEK293T'\n",
       "\\item 'HIMG001'\n",
       "\\item 'HIMG002'\n",
       "\\item 'HME'\n",
       "\\item 'HMELZ'\n",
       "\\item 'HPTEC'\n",
       "\\item 'HS27A'\n",
       "\\item 'HUES3'\n",
       "\\item 'HUH751'\n",
       "\\item 'HUVEC'\n",
       "\\item 'IPS-15-2'\n",
       "\\item 'IPS-3'\n",
       "\\item 'IPS-ND34732'\n",
       "\\item 'LHSAR'\n",
       "\\item 'MCH58'\n",
       "\\item 'MCLF0067SZ'\n",
       "\\item 'MCLF015CN'\n",
       "\\item 'MCLF022CN'\n",
       "\\item 'MCLF027CN'\n",
       "\\item 'MCLF033SZ'\n",
       "\\item 'MCLF035SZ'\n",
       "\\item 'MCLF037SZ'\n",
       "\\item 'MCLF040SZ'\n",
       "\\item 'MCLF051CN'\n",
       "\\item 'MCLF054CN'\n",
       "\\item 'MCLF056CN'\n",
       "\\item 'MCLF076SZ'\n",
       "\\item 'MCLF100SZ'\n",
       "\\item 'MCLF117SZ'\n",
       "\\item 'MCLF123SZ'\n",
       "\\item 'MCLF126CN'\n",
       "\\item 'MCLF130CN'\n",
       "\\item 'MCLF135CN'\n",
       "\\item 'MCLF137CN'\n",
       "\\item 'MCLF141SZ'\n",
       "\\item 'MCLF162SZ'\n",
       "\\item 'MICROGLIA-PSEN1'\n",
       "\\item 'MNEU'\n",
       "\\item 'NAMEC8'\n",
       "\\item 'ND34732\\_7'\n",
       "\\item 'NKDBA'\n",
       "\\item 'P1A82'\n",
       "\\item 'P2X2B2'\n",
       "\\item 'SKB'\n",
       "\\item 'WA09'\n",
       "\\item 'XC.500'\n",
       "\\item 'XC.L10'\n",
       "\\item 'XC.L100'\n",
       "\\item 'XC.P026'\n",
       "\\item 'XC.P031'\n",
       "\\item 'XC.P033'\n",
       "\\item 'XC.P091'\n",
       "\\item 'XC.P092'\n",
       "\\item 'XC.P901'\n",
       "\\item 'XC.P904'\n",
       "\\item 'XC.P905'\n",
       "\\item 'XC.P906'\n",
       "\\item 'XC.P907'\n",
       "\\item 'XC.P908'\n",
       "\\item 'XC.P909'\n",
       "\\item 'XC.P910'\n",
       "\\item 'XC.P911'\n",
       "\\item 'XC.P912'\n",
       "\\item 'XC.P914'\n",
       "\\item 'XC.P915'\n",
       "\\item 'XC.P922'\n",
       "\\item 'XC.P930'\n",
       "\\item 'XC.P931'\n",
       "\\item 'XC.P932'\n",
       "\\item 'XC.P933'\n",
       "\\item 'XC.P934'\n",
       "\\item 'XC.P935'\n",
       "\\item 'XC.P936'\n",
       "\\item 'XC.R10'\n",
       "\\item 'HME1'\n",
       "\\item 'BJAB'\n",
       "\\item 'HBL1'\n",
       "\\item 'OCILY10'\n",
       "\\item 'TMD8'\n",
       "\\item 'TC32'\n",
       "\\item 'H1299'\n",
       "\\item 'H1975'\n",
       "\\item 'HCC515'\n",
       "\\item 'SALE'\n",
       "\\item 'SHSY5Y'\n",
       "\\item '22RV1'\n",
       "\\item 'HEC1A'\n",
       "\\item 'NL20'\n",
       "\\item 'PHH'\n",
       "\\item 'HA1E'\n",
       "\\item 'HEK293'\n",
       "\\item 'HEKTE'\n",
       "\\item 'NEU'\n",
       "\\item 'NPC'\n",
       "\\item 'ASC'\n",
       "\\item 'U266B1'\n",
       "\\item 'HL60'\n",
       "\\item 'K562'\n",
       "\\item 'TF1'\n",
       "\\item 'THP1'\n",
       "\\item 'MINO'\n",
       "\\item 'U937'\n",
       "\\item 'A673'\n",
       "\\item 'SKES1'\n",
       "\\item 'U2OS'\n",
       "\\item 'A549'\n",
       "\\item 'HCC827'\n",
       "\\item 'NCIH1437'\n",
       "\\item 'NCIH1563'\n",
       "\\item 'NCIH1573'\n",
       "\\item 'NCIH1694'\n",
       "\\item 'NCIH1781'\n",
       "\\item 'NCIH1836'\n",
       "\\item 'NCIH1975'\n",
       "\\item 'NCIH2073'\n",
       "\\item 'NCIH2110'\n",
       "\\item 'NCIH2172'\n",
       "\\item 'NCIH596'\n",
       "\\item 'NCIH838'\n",
       "\\item 'NCIH841'\n",
       "\\item 'SKLU1'\n",
       "\\item 'A375'\n",
       "\\item 'SH4'\n",
       "\\item 'SKMEL1'\n",
       "\\item 'SKMEL28'\n",
       "\\item 'SKMEL3'\n",
       "\\item 'SKMEL5'\n",
       "\\item 'LN229'\n",
       "\\item 'DLD1'\n",
       "\\item 'HCT116'\n",
       "\\item 'HT29'\n",
       "\\item 'LOVO'\n",
       "\\item 'NCIH508'\n",
       "\\item 'NCIH716'\n",
       "\\item 'RKO'\n",
       "\\item 'SW480'\n",
       "\\item 'SW620'\n",
       "\\item 'SW948'\n",
       "\\item 'HEPG2'\n",
       "\\item 'BT20'\n",
       "\\item 'BT474'\n",
       "\\item 'HS578T'\n",
       "\\item 'MCF10A'\n",
       "\\item 'MCF7'\n",
       "\\item 'MDAMB231'\n",
       "\\item 'MDAMB468'\n",
       "\\item 'SKBR3'\n",
       "\\item 'T47D'\n",
       "\\item 'ZR751'\n",
       "\\item 'G401'\n",
       "\\item 'SKNSH'\n",
       "\\item '5637'\n",
       "\\item 'J82'\n",
       "\\item 'AGS'\n",
       "\\item 'ES2'\n",
       "\\item 'HELA'\n",
       "\\item 'DU145'\n",
       "\\item 'PC3'\n",
       "\\item 'RWPE1'\n",
       "\\item 'VCAP'\n",
       "\\item 'A204'\n",
       "\\item 'AN3CA'\n",
       "\\item 'TOV112D'\n",
       "\\item 'WI38'\n",
       "\\item 'JURKAT'\n",
       "\\item 'NALM6'\n",
       "\\item 'PL21'\n",
       "\\item 'OCILY19'\n",
       "\\item 'SUDHL4'\n",
       "\\item 'WSUDLCL2'\n",
       "\\item 'BEN'\n",
       "\\item 'DV90'\n",
       "\\item 'HCC15'\n",
       "\\item 'HCC44'\n",
       "\\item 'IGR37'\n",
       "\\item 'MELHO'\n",
       "\\item 'CL34'\n",
       "\\item 'BC3C'\n",
       "\\item 'CAL29'\n",
       "\\item 'VMCUB1'\n",
       "\\item 'EFO27'\n",
       "\\item 'LNCAP'\n",
       "\\item 'YAPC'\n",
       "\\item 'MFE319'\n",
       "\\item 'OC314'\n",
       "\\item 'OC316'\n",
       "\\item 'HFL1'\n",
       "\\item 'IMR90'\n",
       "\\item 'HCC1588'\n",
       "\\item 'HCC95'\n",
       "\\item 'SNU1040'\n",
       "\\item 'SNU407'\n",
       "\\item 'SNUC4'\n",
       "\\item 'SNUC5'\n",
       "\\item 'CORL23'\n",
       "\\item 'GP2D'\n",
       "\\item 'HT115'\n",
       "\\item 'MDST8'\n",
       "\\item 'COV434'\n",
       "\\item 'COV644'\n",
       "\\item 'OAW28'\n",
       "\\item 'OV7'\n",
       "\\item 'BICR6'\n",
       "\\item 'KMS34'\n",
       "\\item 'NOMO1'\n",
       "\\item 'SKM1'\n",
       "\\item 'U251MG'\n",
       "\\item 'YH13'\n",
       "\\item 'HUH7'\n",
       "\\item 'JHH5'\n",
       "\\item 'JHH7'\n",
       "\\item 'IM95'\n",
       "\\item 'MKN45'\n",
       "\\item 'OVTOKO'\n",
       "\\item 'RMGI'\n",
       "\\item 'RMUGS'\n",
       "\\item 'TYKNU'\n",
       "\\item 'HEC108'\n",
       "\\item 'HEC151'\n",
       "\\item 'HEC251'\n",
       "\\item 'HEC265'\n",
       "\\item 'SNGM'\n",
       "\\item 'SKL'\n",
       "\\item 'T3M10'\n",
       "\\item 'CJM'\n",
       "\\item 'GI1'\n",
       "\\item 'CW2'\n",
       "\\item 'RCC10RGB'\n",
       "\\item 'OVK18'\n",
       "\\item 'JHUEM2'\n",
       "\\item 'OVCAR8'\n",
       "\\item 'OCILY3'\n",
       "\\end{enumerate*}\n"
      ],
      "text/markdown": [
       "1. '1HAE'\n",
       "2. 'AALE'\n",
       "3. 'AG06263_2'\n",
       "4. 'AG06840_A'\n",
       "5. 'AG078N1_1'\n",
       "6. 'C42'\n",
       "7. 'CD34'\n",
       "8. 'HAP1'\n",
       "9. 'HEK293T'\n",
       "10. 'HIMG001'\n",
       "11. 'HIMG002'\n",
       "12. 'HME'\n",
       "13. 'HMELZ'\n",
       "14. 'HPTEC'\n",
       "15. 'HS27A'\n",
       "16. 'HUES3'\n",
       "17. 'HUH751'\n",
       "18. 'HUVEC'\n",
       "19. 'IPS-15-2'\n",
       "20. 'IPS-3'\n",
       "21. 'IPS-ND34732'\n",
       "22. 'LHSAR'\n",
       "23. 'MCH58'\n",
       "24. 'MCLF0067SZ'\n",
       "25. 'MCLF015CN'\n",
       "26. 'MCLF022CN'\n",
       "27. 'MCLF027CN'\n",
       "28. 'MCLF033SZ'\n",
       "29. 'MCLF035SZ'\n",
       "30. 'MCLF037SZ'\n",
       "31. 'MCLF040SZ'\n",
       "32. 'MCLF051CN'\n",
       "33. 'MCLF054CN'\n",
       "34. 'MCLF056CN'\n",
       "35. 'MCLF076SZ'\n",
       "36. 'MCLF100SZ'\n",
       "37. 'MCLF117SZ'\n",
       "38. 'MCLF123SZ'\n",
       "39. 'MCLF126CN'\n",
       "40. 'MCLF130CN'\n",
       "41. 'MCLF135CN'\n",
       "42. 'MCLF137CN'\n",
       "43. 'MCLF141SZ'\n",
       "44. 'MCLF162SZ'\n",
       "45. 'MICROGLIA-PSEN1'\n",
       "46. 'MNEU'\n",
       "47. 'NAMEC8'\n",
       "48. 'ND34732_7'\n",
       "49. 'NKDBA'\n",
       "50. 'P1A82'\n",
       "51. 'P2X2B2'\n",
       "52. 'SKB'\n",
       "53. 'WA09'\n",
       "54. 'XC.500'\n",
       "55. 'XC.L10'\n",
       "56. 'XC.L100'\n",
       "57. 'XC.P026'\n",
       "58. 'XC.P031'\n",
       "59. 'XC.P033'\n",
       "60. 'XC.P091'\n",
       "61. 'XC.P092'\n",
       "62. 'XC.P901'\n",
       "63. 'XC.P904'\n",
       "64. 'XC.P905'\n",
       "65. 'XC.P906'\n",
       "66. 'XC.P907'\n",
       "67. 'XC.P908'\n",
       "68. 'XC.P909'\n",
       "69. 'XC.P910'\n",
       "70. 'XC.P911'\n",
       "71. 'XC.P912'\n",
       "72. 'XC.P914'\n",
       "73. 'XC.P915'\n",
       "74. 'XC.P922'\n",
       "75. 'XC.P930'\n",
       "76. 'XC.P931'\n",
       "77. 'XC.P932'\n",
       "78. 'XC.P933'\n",
       "79. 'XC.P934'\n",
       "80. 'XC.P935'\n",
       "81. 'XC.P936'\n",
       "82. 'XC.R10'\n",
       "83. 'HME1'\n",
       "84. 'BJAB'\n",
       "85. 'HBL1'\n",
       "86. 'OCILY10'\n",
       "87. 'TMD8'\n",
       "88. 'TC32'\n",
       "89. 'H1299'\n",
       "90. 'H1975'\n",
       "91. 'HCC515'\n",
       "92. 'SALE'\n",
       "93. 'SHSY5Y'\n",
       "94. '22RV1'\n",
       "95. 'HEC1A'\n",
       "96. 'NL20'\n",
       "97. 'PHH'\n",
       "98. 'HA1E'\n",
       "99. 'HEK293'\n",
       "100. 'HEKTE'\n",
       "101. 'NEU'\n",
       "102. 'NPC'\n",
       "103. 'ASC'\n",
       "104. 'U266B1'\n",
       "105. 'HL60'\n",
       "106. 'K562'\n",
       "107. 'TF1'\n",
       "108. 'THP1'\n",
       "109. 'MINO'\n",
       "110. 'U937'\n",
       "111. 'A673'\n",
       "112. 'SKES1'\n",
       "113. 'U2OS'\n",
       "114. 'A549'\n",
       "115. 'HCC827'\n",
       "116. 'NCIH1437'\n",
       "117. 'NCIH1563'\n",
       "118. 'NCIH1573'\n",
       "119. 'NCIH1694'\n",
       "120. 'NCIH1781'\n",
       "121. 'NCIH1836'\n",
       "122. 'NCIH1975'\n",
       "123. 'NCIH2073'\n",
       "124. 'NCIH2110'\n",
       "125. 'NCIH2172'\n",
       "126. 'NCIH596'\n",
       "127. 'NCIH838'\n",
       "128. 'NCIH841'\n",
       "129. 'SKLU1'\n",
       "130. 'A375'\n",
       "131. 'SH4'\n",
       "132. 'SKMEL1'\n",
       "133. 'SKMEL28'\n",
       "134. 'SKMEL3'\n",
       "135. 'SKMEL5'\n",
       "136. 'LN229'\n",
       "137. 'DLD1'\n",
       "138. 'HCT116'\n",
       "139. 'HT29'\n",
       "140. 'LOVO'\n",
       "141. 'NCIH508'\n",
       "142. 'NCIH716'\n",
       "143. 'RKO'\n",
       "144. 'SW480'\n",
       "145. 'SW620'\n",
       "146. 'SW948'\n",
       "147. 'HEPG2'\n",
       "148. 'BT20'\n",
       "149. 'BT474'\n",
       "150. 'HS578T'\n",
       "151. 'MCF10A'\n",
       "152. 'MCF7'\n",
       "153. 'MDAMB231'\n",
       "154. 'MDAMB468'\n",
       "155. 'SKBR3'\n",
       "156. 'T47D'\n",
       "157. 'ZR751'\n",
       "158. 'G401'\n",
       "159. 'SKNSH'\n",
       "160. '5637'\n",
       "161. 'J82'\n",
       "162. 'AGS'\n",
       "163. 'ES2'\n",
       "164. 'HELA'\n",
       "165. 'DU145'\n",
       "166. 'PC3'\n",
       "167. 'RWPE1'\n",
       "168. 'VCAP'\n",
       "169. 'A204'\n",
       "170. 'AN3CA'\n",
       "171. 'TOV112D'\n",
       "172. 'WI38'\n",
       "173. 'JURKAT'\n",
       "174. 'NALM6'\n",
       "175. 'PL21'\n",
       "176. 'OCILY19'\n",
       "177. 'SUDHL4'\n",
       "178. 'WSUDLCL2'\n",
       "179. 'BEN'\n",
       "180. 'DV90'\n",
       "181. 'HCC15'\n",
       "182. 'HCC44'\n",
       "183. 'IGR37'\n",
       "184. 'MELHO'\n",
       "185. 'CL34'\n",
       "186. 'BC3C'\n",
       "187. 'CAL29'\n",
       "188. 'VMCUB1'\n",
       "189. 'EFO27'\n",
       "190. 'LNCAP'\n",
       "191. 'YAPC'\n",
       "192. 'MFE319'\n",
       "193. 'OC314'\n",
       "194. 'OC316'\n",
       "195. 'HFL1'\n",
       "196. 'IMR90'\n",
       "197. 'HCC1588'\n",
       "198. 'HCC95'\n",
       "199. 'SNU1040'\n",
       "200. 'SNU407'\n",
       "201. 'SNUC4'\n",
       "202. 'SNUC5'\n",
       "203. 'CORL23'\n",
       "204. 'GP2D'\n",
       "205. 'HT115'\n",
       "206. 'MDST8'\n",
       "207. 'COV434'\n",
       "208. 'COV644'\n",
       "209. 'OAW28'\n",
       "210. 'OV7'\n",
       "211. 'BICR6'\n",
       "212. 'KMS34'\n",
       "213. 'NOMO1'\n",
       "214. 'SKM1'\n",
       "215. 'U251MG'\n",
       "216. 'YH13'\n",
       "217. 'HUH7'\n",
       "218. 'JHH5'\n",
       "219. 'JHH7'\n",
       "220. 'IM95'\n",
       "221. 'MKN45'\n",
       "222. 'OVTOKO'\n",
       "223. 'RMGI'\n",
       "224. 'RMUGS'\n",
       "225. 'TYKNU'\n",
       "226. 'HEC108'\n",
       "227. 'HEC151'\n",
       "228. 'HEC251'\n",
       "229. 'HEC265'\n",
       "230. 'SNGM'\n",
       "231. 'SKL'\n",
       "232. 'T3M10'\n",
       "233. 'CJM'\n",
       "234. 'GI1'\n",
       "235. 'CW2'\n",
       "236. 'RCC10RGB'\n",
       "237. 'OVK18'\n",
       "238. 'JHUEM2'\n",
       "239. 'OVCAR8'\n",
       "240. 'OCILY3'\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "  [1] \"1HAE\"            \"AALE\"            \"AG06263_2\"       \"AG06840_A\"      \n",
       "  [5] \"AG078N1_1\"       \"C42\"             \"CD34\"            \"HAP1\"           \n",
       "  [9] \"HEK293T\"         \"HIMG001\"         \"HIMG002\"         \"HME\"            \n",
       " [13] \"HMELZ\"           \"HPTEC\"           \"HS27A\"           \"HUES3\"          \n",
       " [17] \"HUH751\"          \"HUVEC\"           \"IPS-15-2\"        \"IPS-3\"          \n",
       " [21] \"IPS-ND34732\"     \"LHSAR\"           \"MCH58\"           \"MCLF0067SZ\"     \n",
       " [25] \"MCLF015CN\"       \"MCLF022CN\"       \"MCLF027CN\"       \"MCLF033SZ\"      \n",
       " [29] \"MCLF035SZ\"       \"MCLF037SZ\"       \"MCLF040SZ\"       \"MCLF051CN\"      \n",
       " [33] \"MCLF054CN\"       \"MCLF056CN\"       \"MCLF076SZ\"       \"MCLF100SZ\"      \n",
       " [37] \"MCLF117SZ\"       \"MCLF123SZ\"       \"MCLF126CN\"       \"MCLF130CN\"      \n",
       " [41] \"MCLF135CN\"       \"MCLF137CN\"       \"MCLF141SZ\"       \"MCLF162SZ\"      \n",
       " [45] \"MICROGLIA-PSEN1\" \"MNEU\"            \"NAMEC8\"          \"ND34732_7\"      \n",
       " [49] \"NKDBA\"           \"P1A82\"           \"P2X2B2\"          \"SKB\"            \n",
       " [53] \"WA09\"            \"XC.500\"          \"XC.L10\"          \"XC.L100\"        \n",
       " [57] \"XC.P026\"         \"XC.P031\"         \"XC.P033\"         \"XC.P091\"        \n",
       " [61] \"XC.P092\"         \"XC.P901\"         \"XC.P904\"         \"XC.P905\"        \n",
       " [65] \"XC.P906\"         \"XC.P907\"         \"XC.P908\"         \"XC.P909\"        \n",
       " [69] \"XC.P910\"         \"XC.P911\"         \"XC.P912\"         \"XC.P914\"        \n",
       " [73] \"XC.P915\"         \"XC.P922\"         \"XC.P930\"         \"XC.P931\"        \n",
       " [77] \"XC.P932\"         \"XC.P933\"         \"XC.P934\"         \"XC.P935\"        \n",
       " [81] \"XC.P936\"         \"XC.R10\"          \"HME1\"            \"BJAB\"           \n",
       " [85] \"HBL1\"            \"OCILY10\"         \"TMD8\"            \"TC32\"           \n",
       " [89] \"H1299\"           \"H1975\"           \"HCC515\"          \"SALE\"           \n",
       " [93] \"SHSY5Y\"          \"22RV1\"           \"HEC1A\"           \"NL20\"           \n",
       " [97] \"PHH\"             \"HA1E\"            \"HEK293\"          \"HEKTE\"          \n",
       "[101] \"NEU\"             \"NPC\"             \"ASC\"             \"U266B1\"         \n",
       "[105] \"HL60\"            \"K562\"            \"TF1\"             \"THP1\"           \n",
       "[109] \"MINO\"            \"U937\"            \"A673\"            \"SKES1\"          \n",
       "[113] \"U2OS\"            \"A549\"            \"HCC827\"          \"NCIH1437\"       \n",
       "[117] \"NCIH1563\"        \"NCIH1573\"        \"NCIH1694\"        \"NCIH1781\"       \n",
       "[121] \"NCIH1836\"        \"NCIH1975\"        \"NCIH2073\"        \"NCIH2110\"       \n",
       "[125] \"NCIH2172\"        \"NCIH596\"         \"NCIH838\"         \"NCIH841\"        \n",
       "[129] \"SKLU1\"           \"A375\"            \"SH4\"             \"SKMEL1\"         \n",
       "[133] \"SKMEL28\"         \"SKMEL3\"          \"SKMEL5\"          \"LN229\"          \n",
       "[137] \"DLD1\"            \"HCT116\"          \"HT29\"            \"LOVO\"           \n",
       "[141] \"NCIH508\"         \"NCIH716\"         \"RKO\"             \"SW480\"          \n",
       "[145] \"SW620\"           \"SW948\"           \"HEPG2\"           \"BT20\"           \n",
       "[149] \"BT474\"           \"HS578T\"          \"MCF10A\"          \"MCF7\"           \n",
       "[153] \"MDAMB231\"        \"MDAMB468\"        \"SKBR3\"           \"T47D\"           \n",
       "[157] \"ZR751\"           \"G401\"            \"SKNSH\"           \"5637\"           \n",
       "[161] \"J82\"             \"AGS\"             \"ES2\"             \"HELA\"           \n",
       "[165] \"DU145\"           \"PC3\"             \"RWPE1\"           \"VCAP\"           \n",
       "[169] \"A204\"            \"AN3CA\"           \"TOV112D\"         \"WI38\"           \n",
       "[173] \"JURKAT\"          \"NALM6\"           \"PL21\"            \"OCILY19\"        \n",
       "[177] \"SUDHL4\"          \"WSUDLCL2\"        \"BEN\"             \"DV90\"           \n",
       "[181] \"HCC15\"           \"HCC44\"           \"IGR37\"           \"MELHO\"          \n",
       "[185] \"CL34\"            \"BC3C\"            \"CAL29\"           \"VMCUB1\"         \n",
       "[189] \"EFO27\"           \"LNCAP\"           \"YAPC\"            \"MFE319\"         \n",
       "[193] \"OC314\"           \"OC316\"           \"HFL1\"            \"IMR90\"          \n",
       "[197] \"HCC1588\"         \"HCC95\"           \"SNU1040\"         \"SNU407\"         \n",
       "[201] \"SNUC4\"           \"SNUC5\"           \"CORL23\"          \"GP2D\"           \n",
       "[205] \"HT115\"           \"MDST8\"           \"COV434\"          \"COV644\"         \n",
       "[209] \"OAW28\"           \"OV7\"             \"BICR6\"           \"KMS34\"          \n",
       "[213] \"NOMO1\"           \"SKM1\"            \"U251MG\"          \"YH13\"           \n",
       "[217] \"HUH7\"            \"JHH5\"            \"JHH7\"            \"IM95\"           \n",
       "[221] \"MKN45\"           \"OVTOKO\"          \"RMGI\"            \"RMUGS\"          \n",
       "[225] \"TYKNU\"           \"HEC108\"          \"HEC151\"          \"HEC251\"         \n",
       "[229] \"HEC265\"          \"SNGM\"            \"SKL\"             \"T3M10\"          \n",
       "[233] \"CJM\"             \"GI1\"             \"CW2\"             \"RCC10RGB\"       \n",
       "[237] \"OVK18\"           \"JHUEM2\"          \"OVCAR8\"          \"OCILY3\"         "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "cellinfo_beta <- read.table(file = \"cellinfo_beta.modify.txt\", header = T, stringsAsFactors = F, sep = \"\\t\", comment.char = \"!\")\n",
    "cellinfo_beta$cell_iname"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "id": "16a3c5f4-a7e8-4e7e-bdc1-60c838a2daf5",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:22:57.611433Z",
     "iopub.status.busy": "2021-09-23T06:22:57.607919Z",
     "iopub.status.idle": "2021-09-23T06:22:57.657961Z",
     "shell.execute_reply": "2021-09-23T06:22:57.656660Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 5 × 20</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>cell_iname</th><th scope=col>cellosaurus_id</th><th scope=col>donor_age</th><th scope=col>donor_age_death</th><th scope=col>donor_disease_age_onset</th><th scope=col>doubling_time</th><th scope=col>growth_medium</th><th scope=col>provider_catalog_id</th><th scope=col>feature_id</th><th scope=col>cell_type</th><th scope=col>donor_ethnicity</th><th scope=col>donor_sex</th><th scope=col>donor_tumor_phase</th><th scope=col>cell_lineage</th><th scope=col>primary_disease</th><th scope=col>subtype</th><th scope=col>provider_name</th><th scope=col>growth_pattern</th><th scope=col>ccle_name</th><th scope=col>cell_alias</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;lgl&gt;</th><th scope=col>&lt;lgl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>98</th><td>HA1E    </td><td>         </td><td>        </td><td>NA</td><td>NA</td><td>60 </td><td>MEM-ALPHA (Invitrogen A1049001) supplemented with 10% v/v fetal bovine serum (Sigma F4135) and 1% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016)                                               </td><td>        </td><td>     </td><td>normal</td><td>Unknown  </td><td>Unknown</td><td>Unknown</td><td>kidney     </td><td>normal kidney sample</td><td>normal kidney sample          </td><td>     </td><td>unknown </td><td>HA1E_KIDNEY     </td><td>           </td></tr>\n",
       "\t<tr><th scope=row>99</th><td>HEK293  </td><td>CVCL_0045</td><td>        </td><td>NA</td><td>NA</td><td>24 </td><td>ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%.</td><td>        </td><td>     </td><td>normal</td><td>Unknown  </td><td>F      </td><td>Unknown</td><td>kidney     </td><td>normal kidney sample</td><td>normal embryonal kidney sample</td><td>     </td><td>adherent</td><td>                </td><td>293        </td></tr>\n",
       "\t<tr><th scope=row>100</th><td>HEKTE   </td><td>         </td><td>        </td><td>NA</td><td>NA</td><td>   </td><td>                                                                                                                                                                                                              </td><td>        </td><td>     </td><td>normal</td><td>Unknown  </td><td>Unknown</td><td>Unknown</td><td>kidney     </td><td>normal kidney sample</td><td>normal kidney sample          </td><td>     </td><td>unknown </td><td>HEKTE_KIDNEY    </td><td>HEK TE     </td></tr>\n",
       "\t<tr><th scope=row>158</th><td>G401    </td><td>CVCL_0270</td><td>3 months</td><td>NA</td><td>NA</td><td>48 </td><td>McCoys5A                                                                                                                                                                                                      </td><td>CRL-1441</td><td>c-108</td><td>tumor </td><td>Caucasian</td><td>M      </td><td>Primary</td><td>soft_tissue</td><td>kidney cancer       </td><td>carcinoma                     </td><td>ATCC </td><td>adherent</td><td>G401_SOFT_TISSUE</td><td>G 401|G-401</td></tr>\n",
       "\t<tr><th scope=row>236</th><td>RCC10RGB</td><td>CVCL_1647</td><td>        </td><td>NA</td><td>NA</td><td>108</td><td>DMEM+ 1%FBS                                                                                                                                                                                                   </td><td>        </td><td>c-526</td><td>tumor </td><td>Unknown  </td><td>M      </td><td>Unknown</td><td>kidney     </td><td>kidney cancer       </td><td>carcinoma                     </td><td>RIKEN</td><td>adherent</td><td>RCC10RGB_KIDNEY </td><td>10RGB      </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 5 × 20\n",
       "\\begin{tabular}{r|llllllllllllllllllll}\n",
       "  & cell\\_iname & cellosaurus\\_id & donor\\_age & donor\\_age\\_death & donor\\_disease\\_age\\_onset & doubling\\_time & growth\\_medium & provider\\_catalog\\_id & feature\\_id & cell\\_type & donor\\_ethnicity & donor\\_sex & donor\\_tumor\\_phase & cell\\_lineage & primary\\_disease & subtype & provider\\_name & growth\\_pattern & ccle\\_name & cell\\_alias\\\\\n",
       "  & <chr> & <chr> & <chr> & <lgl> & <lgl> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <chr>\\\\\n",
       "\\hline\n",
       "\t98 & HA1E     &           &          & NA & NA & 60  & MEM-ALPHA (Invitrogen A1049001) supplemented with 10\\% v/v fetal bovine serum (Sigma F4135) and 1\\% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016)                                                &          &       & normal & Unknown   & Unknown & Unknown & kidney      & normal kidney sample & normal kidney sample           &       & unknown  & HA1E\\_KIDNEY      &            \\\\\n",
       "\t99 & HEK293   & CVCL\\_0045 &          & NA & NA & 24  & ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10\\%. &          &       & normal & Unknown   & F       & Unknown & kidney      & normal kidney sample & normal embryonal kidney sample &       & adherent &                  & 293        \\\\\n",
       "\t100 & HEKTE    &           &          & NA & NA &     &                                                                                                                                                                                                                &          &       & normal & Unknown   & Unknown & Unknown & kidney      & normal kidney sample & normal kidney sample           &       & unknown  & HEKTE\\_KIDNEY     & HEK TE     \\\\\n",
       "\t158 & G401     & CVCL\\_0270 & 3 months & NA & NA & 48  & McCoys5A                                                                                                                                                                                                       & CRL-1441 & c-108 & tumor  & Caucasian & M       & Primary & soft\\_tissue & kidney cancer        & carcinoma                      & ATCC  & adherent & G401\\_SOFT\\_TISSUE & G 401\\textbar{}G-401\\\\\n",
       "\t236 & RCC10RGB & CVCL\\_1647 &          & NA & NA & 108 & DMEM+ 1\\%FBS                                                                                                                                                                                                    &          & c-526 & tumor  & Unknown   & M       & Unknown & kidney      & kidney cancer        & carcinoma                      & RIKEN & adherent & RCC10RGB\\_KIDNEY  & 10RGB      \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 5 × 20\n",
       "\n",
       "| <!--/--> | cell_iname &lt;chr&gt; | cellosaurus_id &lt;chr&gt; | donor_age &lt;chr&gt; | donor_age_death &lt;lgl&gt; | donor_disease_age_onset &lt;lgl&gt; | doubling_time &lt;chr&gt; | growth_medium &lt;chr&gt; | provider_catalog_id &lt;chr&gt; | feature_id &lt;chr&gt; | cell_type &lt;chr&gt; | donor_ethnicity &lt;chr&gt; | donor_sex &lt;chr&gt; | donor_tumor_phase &lt;chr&gt; | cell_lineage &lt;chr&gt; | primary_disease &lt;chr&gt; | subtype &lt;chr&gt; | provider_name &lt;chr&gt; | growth_pattern &lt;chr&gt; | ccle_name &lt;chr&gt; | cell_alias &lt;chr&gt; |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| 98 | HA1E     | <!----> | <!----> | NA | NA | 60  | MEM-ALPHA (Invitrogen A1049001) supplemented with 10% v/v fetal bovine serum (Sigma F4135) and 1% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016)                                                | <!----> | <!----> | normal | Unknown   | Unknown | Unknown | kidney      | normal kidney sample | normal kidney sample           | <!----> | unknown  | HA1E_KIDNEY      | <!----> |\n",
       "| 99 | HEK293   | CVCL_0045 | <!----> | NA | NA | 24  | ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%. | <!----> | <!----> | normal | Unknown   | F       | Unknown | kidney      | normal kidney sample | normal embryonal kidney sample | <!----> | adherent | <!----> | 293         |\n",
       "| 100 | HEKTE    | <!----> | <!----> | NA | NA | <!----> | <!----> | <!----> | <!----> | normal | Unknown   | Unknown | Unknown | kidney      | normal kidney sample | normal kidney sample           | <!----> | unknown  | HEKTE_KIDNEY     | HEK TE      |\n",
       "| 158 | G401     | CVCL_0270 | 3 months | NA | NA | 48  | McCoys5A                                                                                                                                                                                                       | CRL-1441 | c-108 | tumor  | Caucasian | M       | Primary | soft_tissue | kidney cancer        | carcinoma                      | ATCC  | adherent | G401_SOFT_TISSUE | G 401|G-401 |\n",
       "| 236 | RCC10RGB | CVCL_1647 | <!----> | NA | NA | 108 | DMEM+ 1%FBS                                                                                                                                                                                                    | <!----> | c-526 | tumor  | Unknown   | M       | Unknown | kidney      | kidney cancer        | carcinoma                      | RIKEN | adherent | RCC10RGB_KIDNEY  | 10RGB       |\n",
       "\n"
      ],
      "text/plain": [
       "    cell_iname cellosaurus_id donor_age donor_age_death donor_disease_age_onset\n",
       "98  HA1E                                NA              NA                     \n",
       "99  HEK293     CVCL_0045                NA              NA                     \n",
       "100 HEKTE                               NA              NA                     \n",
       "158 G401       CVCL_0270      3 months  NA              NA                     \n",
       "236 RCC10RGB   CVCL_1647                NA              NA                     \n",
       "    doubling_time\n",
       "98  60           \n",
       "99  24           \n",
       "100              \n",
       "158 48           \n",
       "236 108          \n",
       "    growth_medium                                                                                                                                                                                                 \n",
       "98  MEM-ALPHA (Invitrogen A1049001) supplemented with 10% v/v fetal bovine serum (Sigma F4135) and 1% 100X penicillin-streptomycin-glutamine (Invitrogen 10378-016)                                               \n",
       "99  ATCC-formulated Eagles Minimum Essential Medium, Catalog No. 30-2003. To make the complete growth medium, add the following components to the base medium: fetal bovine serum to a final concentration of 10%.\n",
       "100                                                                                                                                                                                                               \n",
       "158 McCoys5A                                                                                                                                                                                                      \n",
       "236 DMEM+ 1%FBS                                                                                                                                                                                                   \n",
       "    provider_catalog_id feature_id cell_type donor_ethnicity donor_sex\n",
       "98                                 normal    Unknown         Unknown  \n",
       "99                                 normal    Unknown         F        \n",
       "100                                normal    Unknown         Unknown  \n",
       "158 CRL-1441            c-108      tumor     Caucasian       M        \n",
       "236                     c-526      tumor     Unknown         M        \n",
       "    donor_tumor_phase cell_lineage primary_disease     \n",
       "98  Unknown           kidney       normal kidney sample\n",
       "99  Unknown           kidney       normal kidney sample\n",
       "100 Unknown           kidney       normal kidney sample\n",
       "158 Primary           soft_tissue  kidney cancer       \n",
       "236 Unknown           kidney       kidney cancer       \n",
       "    subtype                        provider_name growth_pattern\n",
       "98  normal kidney sample                         unknown       \n",
       "99  normal embryonal kidney sample               adherent      \n",
       "100 normal kidney sample                         unknown       \n",
       "158 carcinoma                      ATCC          adherent      \n",
       "236 carcinoma                      RIKEN         adherent      \n",
       "    ccle_name        cell_alias \n",
       "98  HA1E_KIDNEY                 \n",
       "99                   293        \n",
       "100 HEKTE_KIDNEY     HEK TE     \n",
       "158 G401_SOFT_TISSUE G 401|G-401\n",
       "236 RCC10RGB_KIDNEY  10RGB      "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "#kidney cell line\n",
    "index <- grep(\"kidney\", cellinfo_beta$primary_disease)\n",
    "cellinfo_beta[index,]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "id": "30ad500d-8d9c-48f3-9e21-58fa3b552151",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:23:00.915705Z",
     "iopub.status.busy": "2021-09-23T06:23:00.912259Z",
     "iopub.status.idle": "2021-09-23T06:23:00.957267Z",
     "shell.execute_reply": "2021-09-23T06:23:00.955958Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<dl>\n",
       "\t<dt>$`769P`</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$`786O`</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$A704</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$A498</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$ACHN</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$CaKi</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$HEK293</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$RCC</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$HEKTE</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$HA1E</dt>\n",
       "\t\t<dd><table class=\"dataframe\">\n",
       "<caption>A data.frame: 11 × 5</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;fct&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>67</th><td>aminomethyltransferase__HA1E__trt_cp</td><td>HOXC5</td><td>-2.349426</td><td>aminomethyltransferase</td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>72</th><td>anagrelide__HA1E__trt_cp            </td><td>ISL1 </td><td>-2.888882</td><td>anagrelide            </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>74</th><td>ARP-101__HA1E__trt_cp               </td><td>HOXC5</td><td>-2.420850</td><td>ARP-101               </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>76</th><td>AVA__HA1E__trt_cp                   </td><td>VENTX</td><td>-2.028199</td><td>AVA                   </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>101</th><td>BRD-A51929314__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.227154</td><td>BRD-A51929314         </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>117</th><td>BRD-K05402890__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.309873</td><td>BRD-K05402890         </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>231</th><td>homoharringtonine__HA1E__trt_cp     </td><td>HOXC5</td><td>-2.545411</td><td>homoharringtonine     </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>282</th><td>R-59022__HA1E__trt_cp               </td><td>HOXC5</td><td>-2.440392</td><td>R-59022               </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>303</th><td>ST-638__HA1E__trt_cp                </td><td>ISL1 </td><td>-2.139165</td><td>ST-638                </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>314</th><td>tributyltin__HA1E__trt_cp           </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin           </td><td>HA1E</td></tr>\n",
       "\t<tr><th scope=row>315</th><td>triphenyl-tin__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin         </td><td>HA1E</td></tr>\n",
       "</tbody>\n",
       "</table>\n",
       "</dd>\n",
       "\t<dt>$G401</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "\t<dt>$RCC10RGB</dt>\n",
       "\t\t<dd>NULL</dd>\n",
       "</dl>\n"
      ],
      "text/latex": [
       "\\begin{description}\n",
       "\\item[\\$`769P`] NULL\n",
       "\\item[\\$`786O`] NULL\n",
       "\\item[\\$A704] NULL\n",
       "\\item[\\$A498] NULL\n",
       "\\item[\\$ACHN] NULL\n",
       "\\item[\\$CaKi] NULL\n",
       "\\item[\\$HEK293] NULL\n",
       "\\item[\\$RCC] NULL\n",
       "\\item[\\$HEKTE] NULL\n",
       "\\item[\\$HA1E] A data.frame: 11 × 5\n",
       "\\begin{tabular}{r|lllll}\n",
       "  & Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
       "  & <chr> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
       "\\hline\n",
       "\t67 & aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.349426 & aminomethyltransferase & HA1E\\\\\n",
       "\t72 & anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & ISL1  & -2.888882 & anagrelide             & HA1E\\\\\n",
       "\t74 & ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & HOXC5 & -2.420850 & ARP-101                & HA1E\\\\\n",
       "\t76 & AVA\\_\\_HA1E\\_\\_trt\\_cp                    & VENTX & -2.028199 & AVA                    & HA1E\\\\\n",
       "\t101 & BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.227154 & BRD-A51929314          & HA1E\\\\\n",
       "\t117 & BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.309873 & BRD-K05402890          & HA1E\\\\\n",
       "\t231 & homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp      & HOXC5 & -2.545411 & homoharringtonine      & HA1E\\\\\n",
       "\t282 & R-59022\\_\\_HA1E\\_\\_trt\\_cp                & HOXC5 & -2.440392 & R-59022                & HA1E\\\\\n",
       "\t303 & ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & ISL1  & -2.139165 & ST-638                 & HA1E\\\\\n",
       "\t314 & tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & ISL1  & -3.094550 & tributyltin            & HA1E\\\\\n",
       "\t315 & triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.005953 & triphenyl-tin          & HA1E\\\\\n",
       "\\end{tabular}\n",
       "\n",
       "\\item[\\$G401] NULL\n",
       "\\item[\\$RCC10RGB] NULL\n",
       "\\end{description}\n"
      ],
      "text/markdown": [
       "$`769P`\n",
       ":   NULL\n",
       "$`786O`\n",
       ":   NULL\n",
       "$A704\n",
       ":   NULL\n",
       "$A498\n",
       ":   NULL\n",
       "$ACHN\n",
       ":   NULL\n",
       "$CaKi\n",
       ":   NULL\n",
       "$HEK293\n",
       ":   NULL\n",
       "$RCC\n",
       ":   NULL\n",
       "$HEKTE\n",
       ":   NULL\n",
       "$HA1E\n",
       ":   \n",
       "A data.frame: 11 × 5\n",
       "\n",
       "| <!--/--> | Drug &lt;chr&gt; | TF &lt;chr&gt; | ZSCORE &lt;dbl&gt; | Drug.name &lt;fct&gt; | cellLine &lt;chr&gt; |\n",
       "|---|---|---|---|---|---|\n",
       "| 67 | aminomethyltransferase__HA1E__trt_cp | HOXC5 | -2.349426 | aminomethyltransferase | HA1E |\n",
       "| 72 | anagrelide__HA1E__trt_cp             | ISL1  | -2.888882 | anagrelide             | HA1E |\n",
       "| 74 | ARP-101__HA1E__trt_cp                | HOXC5 | -2.420850 | ARP-101                | HA1E |\n",
       "| 76 | AVA__HA1E__trt_cp                    | VENTX | -2.028199 | AVA                    | HA1E |\n",
       "| 101 | BRD-A51929314__HA1E__trt_cp          | ISL1  | -2.227154 | BRD-A51929314          | HA1E |\n",
       "| 117 | BRD-K05402890__HA1E__trt_cp          | ISL1  | -2.309873 | BRD-K05402890          | HA1E |\n",
       "| 231 | homoharringtonine__HA1E__trt_cp      | HOXC5 | -2.545411 | homoharringtonine      | HA1E |\n",
       "| 282 | R-59022__HA1E__trt_cp                | HOXC5 | -2.440392 | R-59022                | HA1E |\n",
       "| 303 | ST-638__HA1E__trt_cp                 | ISL1  | -2.139165 | ST-638                 | HA1E |\n",
       "| 314 | tributyltin__HA1E__trt_cp            | ISL1  | -3.094550 | tributyltin            | HA1E |\n",
       "| 315 | triphenyl-tin__HA1E__trt_cp          | ISL1  | -2.005953 | triphenyl-tin          | HA1E |\n",
       "\n",
       "\n",
       "$G401\n",
       ":   NULL\n",
       "$RCC10RGB\n",
       ":   NULL\n",
       "\n",
       "\n"
      ],
      "text/plain": [
       "$`769P`\n",
       "NULL\n",
       "\n",
       "$`786O`\n",
       "NULL\n",
       "\n",
       "$A704\n",
       "NULL\n",
       "\n",
       "$A498\n",
       "NULL\n",
       "\n",
       "$ACHN\n",
       "NULL\n",
       "\n",
       "$CaKi\n",
       "NULL\n",
       "\n",
       "$HEK293\n",
       "NULL\n",
       "\n",
       "$RCC\n",
       "NULL\n",
       "\n",
       "$HEKTE\n",
       "NULL\n",
       "\n",
       "$HA1E\n",
       "                                    Drug    TF    ZSCORE              Drug.name\n",
       "67  aminomethyltransferase__HA1E__trt_cp HOXC5 -2.349426 aminomethyltransferase\n",
       "72              anagrelide__HA1E__trt_cp  ISL1 -2.888882             anagrelide\n",
       "74                 ARP-101__HA1E__trt_cp HOXC5 -2.420850                ARP-101\n",
       "76                     AVA__HA1E__trt_cp VENTX -2.028199                    AVA\n",
       "101          BRD-A51929314__HA1E__trt_cp  ISL1 -2.227154          BRD-A51929314\n",
       "117          BRD-K05402890__HA1E__trt_cp  ISL1 -2.309873          BRD-K05402890\n",
       "231      homoharringtonine__HA1E__trt_cp HOXC5 -2.545411      homoharringtonine\n",
       "282                R-59022__HA1E__trt_cp HOXC5 -2.440392                R-59022\n",
       "303                 ST-638__HA1E__trt_cp  ISL1 -2.139165                 ST-638\n",
       "314            tributyltin__HA1E__trt_cp  ISL1 -3.094550            tributyltin\n",
       "315          triphenyl-tin__HA1E__trt_cp  ISL1 -2.005953          triphenyl-tin\n",
       "    cellLine\n",
       "67      HA1E\n",
       "72      HA1E\n",
       "74      HA1E\n",
       "76      HA1E\n",
       "101     HA1E\n",
       "117     HA1E\n",
       "231     HA1E\n",
       "282     HA1E\n",
       "303     HA1E\n",
       "314     HA1E\n",
       "315     HA1E\n",
       "\n",
       "$G401\n",
       "NULL\n",
       "\n",
       "$RCC10RGB\n",
       "NULL\n"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "#Engineered Kidney --- HA1E, HA1E,HK2\n",
    "#kidney; Embryo --- HEK293T\n",
    "RCCl.cellLines <- c(\"769P\", \"786O\", \"A704\", \"A498\", \"ACHN\", \"CaKi\", \"HEK293\", \"RCC\", \"HEKTE\", \"HA1E\", \"G401\", \"RCC10RGB\")\n",
    "RCC.drug.results <- sapply(RCCl.cellLines, function(x){\n",
    "    index <- grep(x, drug.result$Drug)\n",
    "    if(length(index)>0){\n",
    "        return(drug.result[index,])\n",
    "    }else{\n",
    "        return(NULL)\n",
    "    }\n",
    "})\n",
    "RCC.drug.results"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "id": "9d42620e-ae65-45f2-a333-056cd55d70a1",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:23:08.276912Z",
     "iopub.status.busy": "2021-09-23T06:23:08.273429Z",
     "iopub.status.idle": "2021-09-23T06:23:08.317468Z",
     "shell.execute_reply": "2021-09-23T06:23:08.316167Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 11 × 5</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
       "\t<tr><th scope=col>&lt;fct&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;fct&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>HOXC5</td><td>-2.349426</td><td>aminomethyltransferase</td><td>HA1E</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>ISL1 </td><td>-2.888882</td><td>anagrelide            </td><td>HA1E</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>HOXC5</td><td>-2.420850</td><td>ARP-101               </td><td>HA1E</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>VENTX</td><td>-2.028199</td><td>AVA                   </td><td>HA1E</td></tr>\n",
       "\t<tr><td>BRD-A51929314__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.227154</td><td>BRD-A51929314         </td><td>HA1E</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.309873</td><td>BRD-K05402890         </td><td>HA1E</td></tr>\n",
       "\t<tr><td>homoharringtonine__HA1E__trt_cp     </td><td>HOXC5</td><td>-2.545411</td><td>homoharringtonine     </td><td>HA1E</td></tr>\n",
       "\t<tr><td>R-59022__HA1E__trt_cp               </td><td>HOXC5</td><td>-2.440392</td><td>R-59022               </td><td>HA1E</td></tr>\n",
       "\t<tr><td>ST-638__HA1E__trt_cp                </td><td>ISL1 </td><td>-2.139165</td><td>ST-638                </td><td>HA1E</td></tr>\n",
       "\t<tr><td>tributyltin__HA1E__trt_cp           </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin           </td><td>HA1E</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin         </td><td>HA1E</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 11 × 5\n",
       "\\begin{tabular}{lllll}\n",
       " Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
       " <fct> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
       "\\hline\n",
       "\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.349426 & aminomethyltransferase & HA1E\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & ISL1  & -2.888882 & anagrelide             & HA1E\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & HOXC5 & -2.420850 & ARP-101                & HA1E\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & VENTX & -2.028199 & AVA                    & HA1E\\\\\n",
       "\t BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.227154 & BRD-A51929314          & HA1E\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.309873 & BRD-K05402890          & HA1E\\\\\n",
       "\t homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp      & HOXC5 & -2.545411 & homoharringtonine      & HA1E\\\\\n",
       "\t R-59022\\_\\_HA1E\\_\\_trt\\_cp                & HOXC5 & -2.440392 & R-59022                & HA1E\\\\\n",
       "\t ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & ISL1  & -2.139165 & ST-638                 & HA1E\\\\\n",
       "\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & ISL1  & -3.094550 & tributyltin            & HA1E\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.005953 & triphenyl-tin          & HA1E\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 11 × 5\n",
       "\n",
       "| Drug &lt;fct&gt; | TF &lt;chr&gt; | ZSCORE &lt;dbl&gt; | Drug.name &lt;fct&gt; | cellLine &lt;chr&gt; |\n",
       "|---|---|---|---|---|\n",
       "| aminomethyltransferase__HA1E__trt_cp | HOXC5 | -2.349426 | aminomethyltransferase | HA1E |\n",
       "| anagrelide__HA1E__trt_cp             | ISL1  | -2.888882 | anagrelide             | HA1E |\n",
       "| ARP-101__HA1E__trt_cp                | HOXC5 | -2.420850 | ARP-101                | HA1E |\n",
       "| AVA__HA1E__trt_cp                    | VENTX | -2.028199 | AVA                    | HA1E |\n",
       "| BRD-A51929314__HA1E__trt_cp          | ISL1  | -2.227154 | BRD-A51929314          | HA1E |\n",
       "| BRD-K05402890__HA1E__trt_cp          | ISL1  | -2.309873 | BRD-K05402890          | HA1E |\n",
       "| homoharringtonine__HA1E__trt_cp      | HOXC5 | -2.545411 | homoharringtonine      | HA1E |\n",
       "| R-59022__HA1E__trt_cp                | HOXC5 | -2.440392 | R-59022                | HA1E |\n",
       "| ST-638__HA1E__trt_cp                 | ISL1  | -2.139165 | ST-638                 | HA1E |\n",
       "| tributyltin__HA1E__trt_cp            | ISL1  | -3.094550 | tributyltin            | HA1E |\n",
       "| triphenyl-tin__HA1E__trt_cp          | ISL1  | -2.005953 | triphenyl-tin          | HA1E |\n",
       "\n"
      ],
      "text/plain": [
       "   Drug                                 TF    ZSCORE    Drug.name             \n",
       "1  aminomethyltransferase__HA1E__trt_cp HOXC5 -2.349426 aminomethyltransferase\n",
       "2  anagrelide__HA1E__trt_cp             ISL1  -2.888882 anagrelide            \n",
       "3  ARP-101__HA1E__trt_cp                HOXC5 -2.420850 ARP-101               \n",
       "4  AVA__HA1E__trt_cp                    VENTX -2.028199 AVA                   \n",
       "5  BRD-A51929314__HA1E__trt_cp          ISL1  -2.227154 BRD-A51929314         \n",
       "6  BRD-K05402890__HA1E__trt_cp          ISL1  -2.309873 BRD-K05402890         \n",
       "7  homoharringtonine__HA1E__trt_cp      HOXC5 -2.545411 homoharringtonine     \n",
       "8  R-59022__HA1E__trt_cp                HOXC5 -2.440392 R-59022               \n",
       "9  ST-638__HA1E__trt_cp                 ISL1  -2.139165 ST-638                \n",
       "10 tributyltin__HA1E__trt_cp            ISL1  -3.094550 tributyltin           \n",
       "11 triphenyl-tin__HA1E__trt_cp          ISL1  -2.005953 triphenyl-tin         \n",
       "   cellLine\n",
       "1  HA1E    \n",
       "2  HA1E    \n",
       "3  HA1E    \n",
       "4  HA1E    \n",
       "5  HA1E    \n",
       "6  HA1E    \n",
       "7  HA1E    \n",
       "8  HA1E    \n",
       "9  HA1E    \n",
       "10 HA1E    \n",
       "11 HA1E    "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "####output\n",
    "RCC.drug.result <- rbind(RCC.drug.results[[7]], RCC.drug.results[[10]])\n",
    "library (plyr)\n",
    "library(writexl)\n",
    "drug.idx <- sort(table(RCC.drug.result$Drug),decreasing = T)\n",
    "RCC.drug.result$Drug <- factor(RCC.drug.result$Drug, levels = names(drug.idx))\n",
    "RCC.drug.result <- arrange(RCC.drug.result, Drug)\n",
    "write_xlsx(RCC.drug.result, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.negative.drug.result.xlsx\")\n",
    "RCC.drug.result"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 40,
   "id": "ab3e7788-a5fe-46ec-ba50-c149a53e81fb",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:23:15.996376Z",
     "iopub.status.busy": "2021-09-23T06:23:15.992831Z",
     "iopub.status.idle": "2021-09-23T06:23:16.293657Z",
     "shell.execute_reply": "2021-09-23T06:23:16.292420Z"
    },
    "scrolled": true,
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 52 × 36</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>.id</th><th scope=col>bead_batch</th><th scope=col>nearest_dose</th><th scope=col>pert_dose</th><th scope=col>pert_dose_unit</th><th scope=col>pert_idose</th><th scope=col>pert_itime</th><th scope=col>pert_time</th><th scope=col>pert_time_unit</th><th scope=col>cell_mfc_name</th><th scope=col>⋯</th><th scope=col>sig_id</th><th scope=col>pert_type</th><th scope=col>cell_iname</th><th scope=col>det_wells</th><th scope=col>det_plates</th><th scope=col>distil_ids</th><th scope=col>build_name</th><th scope=col>project_code</th><th scope=col>cmap_name</th><th scope=col>is_ncs_exemplar</th></tr>\n",
       "\t<tr><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>⋯</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;lgl&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;int&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC001_HA1E_24H:BRD-A28318179-003-03-6:10    </td><td>trt_cp</td><td>HA1E</td><td>J07                </td><td>CPC001_HA1E_24H_X1_B3_DUO52HI53LO|CPC001_HA1E_24H_X2_B3_DUO52HI53LO|CPC001_HA1E_24H_X3_B3_DUO52HI53LO                                                               </td><td>CPC001_HA1E_24H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X3_B3_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                      </td><td>NA</td><td>CPC  </td><td>aminomethyltransferase</td><td>0</td></tr>\n",
       "\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC001_HA1E_6H:BRD-A28318179-003-03-6:10     </td><td>trt_cp</td><td>HA1E</td><td>J07                </td><td>CPC001_HA1E_6H_X1_B3_DUO52HI53LO|CPC001_HA1E_6H_X2_B3_DUO52HI53LO|CPC001_HA1E_6H_X3_B3_DUO52HI53LO                                                                  </td><td>CPC001_HA1E_6H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X3_B3_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                         </td><td>NA</td><td>CPC  </td><td>aminomethyltransferase</td><td>1</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC004_HA1E_6H:BRD-K62200014-003-05-5:10     </td><td>trt_cp</td><td>HA1E</td><td>L03                </td><td>CPC004_HA1E_6H_X1_B3_DUO52HI53LO|CPC004_HA1E_6H_X2_B3_DUO52HI53LO|CPC004_HA1E_6H_X3_B3_DUO52HI53LO                                                                  </td><td>CPC004_HA1E_6H_X1_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X2_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X3_B3_DUO52HI53LO:L03                                                                                                                                                                                                                                                                                                                                                                                                         </td><td>NA</td><td>CPC  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>f1b3</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC011_HA1E_6H:BRD-K62200014-003-07-1:10     </td><td>trt_cp</td><td>HA1E</td><td>H10                </td><td>CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO                                                                                               </td><td>CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO:H10|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO:H10                                                                                                                                                                                                                                                                                                                                                                                                                                          </td><td>NA</td><td>CPC  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b23 </td><td> 0.740</td><td> 0.76923100</td><td>uM</td><td>0.74 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B14                        </td><td>trt_cp</td><td>HA1E</td><td>B14                </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   </td><td>REP.B018_HA1E_24H_X1_B23:B14|REP.B018_HA1E_24H_X2_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>1</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b24 </td><td> 1.110</td><td> 1.11111000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B15                        </td><td>trt_cp</td><td>HA1E</td><td>B15                </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          </td><td>REP.A018_HA1E_24H_X1_B24:B15|REP.A018_HA1E_24H_X2_B23:B15|REP.A018_HA1E_24H_X3_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b24 </td><td> 0.040</td><td> 0.04115230</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B18                        </td><td>trt_cp</td><td>HA1E</td><td>B18                </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          </td><td>REP.A018_HA1E_24H_X1_B24:B18|REP.A018_HA1E_24H_X2_B23:B18|REP.A018_HA1E_24H_X3_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b23 </td><td> 0.080</td><td> 0.08547010</td><td>uM</td><td>0.08 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B16                        </td><td>trt_cp</td><td>HA1E</td><td>B16                </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   </td><td>REP.B018_HA1E_24H_X1_B23:B16|REP.B018_HA1E_24H_X2_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b24 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B13                        </td><td>trt_cp</td><td>HA1E</td><td>B13                </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          </td><td>REP.A018_HA1E_24H_X1_B24:B13|REP.A018_HA1E_24H_X2_B23:B13|REP.A018_HA1E_24H_X3_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b23 </td><td> 0.250</td><td> 0.25641000</td><td>uM</td><td>0.25 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B15                        </td><td>trt_cp</td><td>HA1E</td><td>B15                </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   </td><td>REP.B018_HA1E_24H_X1_B23:B15|REP.B018_HA1E_24H_X2_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b24 </td><td> 0.125</td><td> 0.12345700</td><td>uM</td><td>0.125 uM</td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B17                        </td><td>trt_cp</td><td>HA1E</td><td>B17                </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          </td><td>REP.A018_HA1E_24H_X1_B24:B17|REP.A018_HA1E_24H_X2_B23:B17|REP.A018_HA1E_24H_X3_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b23 </td><td> 0.010</td><td> 0.00949668</td><td>uM</td><td>0.01 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B18                        </td><td>trt_cp</td><td>HA1E</td><td>B18                </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   </td><td>REP.B018_HA1E_24H_X1_B23:B18|REP.B018_HA1E_24H_X2_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b24 </td><td> 0.370</td><td> 0.37037000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B16                        </td><td>trt_cp</td><td>HA1E</td><td>B16                </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          </td><td>REP.A018_HA1E_24H_X1_B24:B16|REP.A018_HA1E_24H_X2_B23:B16|REP.A018_HA1E_24H_X3_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b24 </td><td> 3.330</td><td> 3.33333000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A018_HA1E_24H:B14                        </td><td>trt_cp</td><td>HA1E</td><td>B14                </td><td>REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          </td><td>REP.A018_HA1E_24H_X1_B24:B14|REP.A018_HA1E_24H_X2_B23:B14|REP.A018_HA1E_24H_X3_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b23 </td><td> 2.220</td><td> 2.30769000</td><td>uM</td><td>2.22 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B13                        </td><td>trt_cp</td><td>HA1E</td><td>B13                </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   </td><td>REP.B018_HA1E_24H_X1_B23:B13|REP.B018_HA1E_24H_X2_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>b23 </td><td> 0.030</td><td> 0.02849000</td><td>uM</td><td>0.03 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B018_HA1E_24H:B17                        </td><td>trt_cp</td><td>HA1E</td><td>B17                </td><td>REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   </td><td>REP.B018_HA1E_24H_X1_B23:B17|REP.B018_HA1E_24H_X2_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>anagrelide            </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC006_HA1E_6H:BRD-K73395020-001-01-5:10     </td><td>trt_cp</td><td>HA1E</td><td>K04                </td><td>CPC006_HA1E_6H_X1_B3_DUO52HI53LO|CPC006_HA1E_6H_X2_B3_DUO52HI53LO|CPC006_HA1E_6H_X3_B3_DUO52HI53LO|CPC006_HA1E_6H_X4_B4_DUO52HI53LO|CPC006_HA1E_6H_X5_B4_DUO52HI53LO</td><td>CPC006_HA1E_6H_X1_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X2_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X3_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X4_B4_DUO52HI53LO:K04|CPC006_HA1E_6H_X5_B4_DUO52HI53LO:K04                                                                                                                                                                                                                                                                                                                               </td><td>NA</td><td>CPC  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b24 </td><td> 0.030</td><td> 0.02849000</td><td>uM</td><td>0.03 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M17                        </td><td>trt_cp</td><td>HA1E</td><td>M17                </td><td>REP.B007_HA1E_24H_X1_B24                                                                                                                                            </td><td>REP.B007_HA1E_24H_X1_B24:M17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b22 </td><td> 0.040</td><td> 0.04115230</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M18                        </td><td>trt_cp</td><td>HA1E</td><td>M18                </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          </td><td>REP.A007_HA1E_24H_X1_B22:M18|REP.A007_HA1E_24H_X2_B24:M18|REP.A007_HA1E_24H_X3_B22:M18                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b24 </td><td> 0.250</td><td> 0.25641000</td><td>uM</td><td>0.25 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M15                        </td><td>trt_cp</td><td>HA1E</td><td>M15                </td><td>REP.B007_HA1E_24H_X1_B24                                                                                                                                            </td><td>REP.B007_HA1E_24H_X1_B24:M15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b22 </td><td> 0.125</td><td> 0.12345700</td><td>uM</td><td>0.125 uM</td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M17                        </td><td>trt_cp</td><td>HA1E</td><td>M17                </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          </td><td>REP.A007_HA1E_24H_X1_B22:M17|REP.A007_HA1E_24H_X2_B24:M17|REP.A007_HA1E_24H_X3_B22:M17                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b24 </td><td> 2.220</td><td> 2.30769000</td><td>uM</td><td>2.22 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M13                        </td><td>trt_cp</td><td>HA1E</td><td>M13                </td><td>REP.B007_HA1E_24H_X1_B24                                                                                                                                            </td><td>REP.B007_HA1E_24H_X1_B24:M13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b24 </td><td> 0.010</td><td> 0.00949668</td><td>uM</td><td>0.01 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M18                        </td><td>trt_cp</td><td>HA1E</td><td>M18                </td><td>REP.B007_HA1E_24H_X1_B24                                                                                                                                            </td><td>REP.B007_HA1E_24H_X1_B24:M18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b24 </td><td> 0.080</td><td> 0.08547010</td><td>uM</td><td>0.08 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M16                        </td><td>trt_cp</td><td>HA1E</td><td>M16                </td><td>REP.B007_HA1E_24H_X1_B24                                                                                                                                            </td><td>REP.B007_HA1E_24H_X1_B24:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b22 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M13                        </td><td>trt_cp</td><td>HA1E</td><td>M13                </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          </td><td>REP.A007_HA1E_24H_X1_B22:M13|REP.A007_HA1E_24H_X2_B24:M13|REP.A007_HA1E_24H_X3_B22:M13                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b22 </td><td> 0.370</td><td> 0.37037000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M16                        </td><td>trt_cp</td><td>HA1E</td><td>M16                </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X3_B22                                                                                                                   </td><td>REP.A007_HA1E_24H_X1_B22:M16|REP.A007_HA1E_24H_X3_B22:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b22 </td><td> 1.110</td><td> 1.11111000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M15                        </td><td>trt_cp</td><td>HA1E</td><td>M15                </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          </td><td>REP.A007_HA1E_24H_X1_B22:M15|REP.A007_HA1E_24H_X2_B24:M15|REP.A007_HA1E_24H_X3_B22:M15                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b22 </td><td> 3.330</td><td> 3.33333000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.A007_HA1E_24H:M14                        </td><td>trt_cp</td><td>HA1E</td><td>M14                </td><td>REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          </td><td>REP.A007_HA1E_24H_X1_B22:M14|REP.A007_HA1E_24H_X2_B24:M14|REP.A007_HA1E_24H_X3_B22:M14                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>1</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>b24 </td><td> 0.740</td><td> 0.76923100</td><td>uM</td><td>0.74 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>REP.B007_HA1E_24H:M14                        </td><td>trt_cp</td><td>HA1E</td><td>M14                </td><td>REP.B007_HA1E_24H_X1_B24                                                                                                                                            </td><td>REP.B007_HA1E_24H_X1_B24:M14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           </td><td>NA</td><td>REP  </td><td>ARP-101               </td><td>0</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>b13 </td><td> 3.330</td><td> 3.33000000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:3.33 </td><td>trt_cp</td><td>HA1E</td><td>N20                </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             </td><td>PCLB003_HA1E_24H_X1_B13:N20|PCLB003_HA1E_24H_X2_B13:N20|PCLB003_HA1E_24H_X3_B13:N20                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>PCLB </td><td>AVA                   </td><td>0</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>b13 </td><td> 0.370</td><td> 0.37000000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.37 </td><td>trt_cp</td><td>HA1E</td><td>N22                </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             </td><td>PCLB003_HA1E_24H_X1_B13:N22|PCLB003_HA1E_24H_X2_B13:N22|PCLB003_HA1E_24H_X3_B13:N22                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>PCLB </td><td>AVA                   </td><td>0</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>b13 </td><td> 1.110</td><td> 1.11000000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:1.11 </td><td>trt_cp</td><td>HA1E</td><td>N21                </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             </td><td>PCLB003_HA1E_24H_X1_B13:N21|PCLB003_HA1E_24H_X2_B13:N21|PCLB003_HA1E_24H_X3_B13:N21                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>PCLB </td><td>AVA                   </td><td>0</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>b13 </td><td> 0.040</td><td> 0.04000000</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.04 </td><td>trt_cp</td><td>HA1E</td><td>N24                </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             </td><td>PCLB003_HA1E_24H_X1_B13:N24|PCLB003_HA1E_24H_X2_B13:N24|PCLB003_HA1E_24H_X3_B13:N24                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>PCLB </td><td>AVA                   </td><td>0</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>b13 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:10   </td><td>trt_cp</td><td>HA1E</td><td>N19                </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             </td><td>PCLB003_HA1E_24H_X1_B13:N19|PCLB003_HA1E_24H_X2_B13:N19|PCLB003_HA1E_24H_X3_B13:N19                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>PCLB </td><td>AVA                   </td><td>1</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>b13 </td><td> 0.120</td><td> 0.12000000</td><td>uM</td><td>0.12 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.12 </td><td>trt_cp</td><td>HA1E</td><td>N23                </td><td>PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             </td><td>PCLB003_HA1E_24H_X1_B13:N23|PCLB003_HA1E_24H_X2_B13:N23|PCLB003_HA1E_24H_X3_B13:N23                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>PCLB </td><td>AVA                   </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>f1b3</td><td> 0.370</td><td> 0.35000000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC006_HA1E_24H:N13                          </td><td>trt_cp</td><td>HA1E</td><td>N13                </td><td>CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO|CPC006_HA1E_24H_X2_B3_DUO52HI53LO|CPC006_HA1E_24H_X3_B3_DUO52HI53LO                                                          </td><td>CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X2_B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X3_B3_DUO52HI53LO:N13                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>CPC  </td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC007_HA1E_24H:BRD-K05402890-001-09-2:10    </td><td>trt_cp</td><td>HA1E</td><td>H03                </td><td>CPC007_HA1E_24H_X1_B3_DUO52HI53LO|CPC007_HA1E_24H_X2_B3_DUO52HI53LO|CPC007_HA1E_24H_X3_B3_DUO52HI53LO                                                               </td><td>CPC007_HA1E_24H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X3_B3_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                      </td><td>NA</td><td>CPC  </td><td>BRD-K05402890         </td><td>1</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC007_HA1E_6H:BRD-K05402890-001-09-2:10     </td><td>trt_cp</td><td>HA1E</td><td>H03                </td><td>CPC007_HA1E_6H_X1_B3_DUO52HI53LO|CPC007_HA1E_6H_X2_B3_DUO52HI53LO|CPC007_HA1E_6H_X3_B3_DUO52HI53LO                                                                  </td><td>CPC007_HA1E_6H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X3_B3_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                         </td><td>NA</td><td>CPC  </td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b21 </td><td> 0.370</td><td> 0.37037000</td><td>uM</td><td>0.37 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L04                        </td><td>trt_cp</td><td>HA1E</td><td>L04                </td><td>PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                                                   </td><td>PBIOA014_HA1E_24H_X2_B21:L04|PBIOA014_HA1E_24H_X3_B21:L04                                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b21 </td><td> 0.125</td><td> 0.12345700</td><td>uM</td><td>0.125 uM</td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L05                        </td><td>trt_cp</td><td>HA1E</td><td>L05                </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          </td><td>PBIOA014_HA1E_24H_X1_B21:L05|PBIOA014_HA1E_24H_X2_B21:L05|PBIOA014_HA1E_24H_X3_B21:L05                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b21 </td><td> 3.330</td><td> 3.33333000</td><td>uM</td><td>3.33 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L02                        </td><td>trt_cp</td><td>HA1E</td><td>L02                </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          </td><td>PBIOA014_HA1E_24H_X1_B21:L02|PBIOA014_HA1E_24H_X2_B21:L02|PBIOA014_HA1E_24H_X3_B21:L02                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b21 </td><td> 1.110</td><td> 1.11111000</td><td>uM</td><td>1.11 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L03                        </td><td>trt_cp</td><td>HA1E</td><td>L03                </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          </td><td>PBIOA014_HA1E_24H_X1_B21:L03|PBIOA014_HA1E_24H_X2_B21:L03|PBIOA014_HA1E_24H_X3_B21:L03                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b21 </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L01                        </td><td>trt_cp</td><td>HA1E</td><td>L01                </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          </td><td>PBIOA014_HA1E_24H_X1_B21:L01|PBIOA014_HA1E_24H_X2_B21:L01|PBIOA014_HA1E_24H_X3_B21:L01                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>b21 </td><td> 0.040</td><td> 0.04115230</td><td>uM</td><td>0.04 uM </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>PBIOA014_HA1E_24H:L06                        </td><td>trt_cp</td><td>HA1E</td><td>L06                </td><td>PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          </td><td>PBIOA014_HA1E_24H_X1_B21:L06|PBIOA014_HA1E_24H_X2_B21:L06|PBIOA014_HA1E_24H_X3_B21:L06                                                                                                                                                                                                                                                                                                                                                                                                                                 </td><td>NA</td><td>PBIOA</td><td>BRD-K05402890         </td><td>0</td></tr>\n",
       "\t<tr><td>R-59022__HA1E__trt_cp               </td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC005_HA1E_6H:BRD-K54665485-001-04-6:10     </td><td>trt_cp</td><td>HA1E</td><td>P15                </td><td>CPC005_HA1E_6H_X3_B3_DUO52HI53LO                                                                                                                                    </td><td>CPC005_HA1E_6H_X3_B3_DUO52HI53LO:P15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   </td><td>NA</td><td>CPC  </td><td>R-59022               </td><td>0</td></tr>\n",
       "\t<tr><td>ST-638__HA1E__trt_cp                </td><td>b3  </td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CPC005_HA1E_6H:BRD-K51476772-001-01-9:10     </td><td>trt_cp</td><td>HA1E</td><td>D03                </td><td>CPC005_HA1E_6H_X1_B3_DUO52HI53LO|CPC005_HA1E_6H_X3_B3_DUO52HI53LO                                                                                                   </td><td>CPC005_HA1E_6H_X1_B3_DUO52HI53LO:D03|CPC005_HA1E_6H_X3_B3_DUO52HI53LO:D03                                                                                                                                                                                                                                                                                                                                                                                                                                              </td><td>NA</td><td>CPC  </td><td>ST-638                </td><td>0</td></tr>\n",
       "\t<tr><td>tributyltin__HA1E__trt_cp           </td><td>f1b7</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN004_HA1E_6H:BRD-K88145757-001-01-6:10   </td><td>trt_cp</td><td>HA1E</td><td>H15|I13|L18        </td><td>CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO                                                                                                                                </td><td>CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:H15|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:I13|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:L18                                                                                                                                                                                                                                                                                                                                                                                             </td><td>NA</td><td>CRCGN</td><td>tributyltin           </td><td>0</td></tr>\n",
       "\t<tr><td>tributyltin__HA1E__trt_cp           </td><td>f1b4</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN001_HA1E_24H:BRD-K88145757-001-01-6:10  </td><td>trt_cp</td><td>HA1E</td><td>H15|I13            </td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO                                                                                         </td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:H15|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:I13                                                                                                                                                                                                                                                                                                                                                                                                                                    </td><td>NA</td><td>CRCGN</td><td>tributyltin           </td><td>1</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>f1b7</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10  </td><td>trt_cp</td><td>HA1E</td><td>D19|F18|G07        </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO                                                   </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07                                                                                                                              </td><td>NA</td><td>CRCGN</td><td>triphenyl-tin         </td><td>0</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>f1b7</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10UM</td><td>trt_cp</td><td>HA1E</td><td>D19|F18|G07        </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO                                                   </td><td>CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07                                                                                                                              </td><td>NA</td><td>CRCGN</td><td>triphenyl-tin         </td><td>0</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>f1b4</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>6 h </td><td> 6</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN001_HA1E_6H:BRD-K78683072-001-01-6:10   </td><td>trt_cp</td><td>HA1E</td><td>D19|F18|G07        </td><td>CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO                                                      </td><td>CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:G07                                                                                                                                       </td><td>NA</td><td>CRCGN</td><td>triphenyl-tin         </td><td>0</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>f1b4</td><td>10.000</td><td>10.00000000</td><td>uM</td><td>10 uM   </td><td>24 h</td><td>24</td><td>h</td><td>HA1E</td><td>⋯</td><td>CRCGN001_HA1E_24H:BRD-K78683072-001-01-6:10  </td><td>trt_cp</td><td>HA1E</td><td>D14|D19|F18|G07|K11</td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO                                                   </td><td>CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:K11|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:G07</td><td>NA</td><td>CRCGN</td><td>triphenyl-tin         </td><td>0</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 52 × 36\n",
       "\\begin{tabular}{lllllllllllllllllllll}\n",
       " .id & bead\\_batch & nearest\\_dose & pert\\_dose & pert\\_dose\\_unit & pert\\_idose & pert\\_itime & pert\\_time & pert\\_time\\_unit & cell\\_mfc\\_name & ⋯ & sig\\_id & pert\\_type & cell\\_iname & det\\_wells & det\\_plates & distil\\_ids & build\\_name & project\\_code & cmap\\_name & is\\_ncs\\_exemplar\\\\\n",
       " <chr> & <chr> & <dbl> & <dbl> & <chr> & <chr> & <chr> & <dbl> & <chr> & <chr> & ⋯ & <chr> & <chr> & <chr> & <chr> & <chr> & <chr> & <lgl> & <chr> & <chr> & <int>\\\\\n",
       "\\hline\n",
       "\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & CPC001\\_HA1E\\_24H:BRD-A28318179-003-03-6:10     & trt\\_cp & HA1E & J07                 & CPC001\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO                                                                & CPC001\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                       & NA & CPC   & aminomethyltransferase & 0\\\\\n",
       "\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC001\\_HA1E\\_6H:BRD-A28318179-003-03-6:10      & trt\\_cp & HA1E & J07                 & CPC001\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC001\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO                                                                   & CPC001\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:J07\\textbar{}CPC001\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                          & NA & CPC   & aminomethyltransferase & 1\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC004\\_HA1E\\_6H:BRD-K62200014-003-05-5:10      & trt\\_cp & HA1E & L03                 & CPC004\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC004\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC004\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO                                                                   & CPC004\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:L03\\textbar{}CPC004\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:L03\\textbar{}CPC004\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:L03                                                                                                                                                                                                                                                                                                                                                                                                          & NA & CPC   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & f1b3 & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC011\\_HA1E\\_6H:BRD-K62200014-003-07-1:10      & trt\\_cp & HA1E & H10                 & CPC011\\_HA1E\\_6H\\_X1\\_F1B3\\_DUO52HI53LO\\textbar{}CPC011\\_HA1E\\_6H\\_X3\\_F1B3\\_DUO52HI53LO                                                                                                & CPC011\\_HA1E\\_6H\\_X1\\_F1B3\\_DUO52HI53LO:H10\\textbar{}CPC011\\_HA1E\\_6H\\_X3\\_F1B3\\_DUO52HI53LO:H10                                                                                                                                                                                                                                                                                                                                                                                                                                           & NA & CPC   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b23  &  0.740 &  0.76923100 & uM & 0.74 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B14                         & trt\\_cp & HA1E & B14                 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23                                                                                                                    & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B14\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & anagrelide             & 1\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b24  &  1.110 &  1.11111000 & uM & 1.11 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B15                         & trt\\_cp & HA1E & B15                 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23                                                                                           & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B15\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B15\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b24  &  0.040 &  0.04115230 & uM & 0.04 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B18                         & trt\\_cp & HA1E & B18                 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23                                                                                           & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B18\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B18\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b23  &  0.080 &  0.08547010 & uM & 0.08 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B16                         & trt\\_cp & HA1E & B16                 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23                                                                                                                    & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B16\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b24  & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B13                         & trt\\_cp & HA1E & B13                 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23                                                                                           & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B13\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B13\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b23  &  0.250 &  0.25641000 & uM & 0.25 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B15                         & trt\\_cp & HA1E & B15                 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23                                                                                                                    & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B15\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b24  &  0.125 &  0.12345700 & uM & 0.125 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B17                         & trt\\_cp & HA1E & B17                 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23                                                                                           & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B17\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B17\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b23  &  0.010 &  0.00949668 & uM & 0.01 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B18                         & trt\\_cp & HA1E & B18                 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23                                                                                                                    & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B18\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b24  &  0.370 &  0.37037000 & uM & 0.37 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B16                         & trt\\_cp & HA1E & B16                 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23                                                                                           & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B16\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B16\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b24  &  3.330 &  3.33333000 & uM & 3.33 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A018\\_HA1E\\_24H:B14                         & trt\\_cp & HA1E & B14                 & REP.A018\\_HA1E\\_24H\\_X1\\_B24\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23                                                                                           & REP.A018\\_HA1E\\_24H\\_X1\\_B24:B14\\textbar{}REP.A018\\_HA1E\\_24H\\_X2\\_B23:B14\\textbar{}REP.A018\\_HA1E\\_24H\\_X3\\_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b23  &  2.220 &  2.30769000 & uM & 2.22 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B13                         & trt\\_cp & HA1E & B13                 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23                                                                                                                    & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B13\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & anagrelide             & 0\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & b23  &  0.030 &  0.02849000 & uM & 0.03 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B018\\_HA1E\\_24H:B17                         & trt\\_cp & HA1E & B17                 & REP.B018\\_HA1E\\_24H\\_X1\\_B23\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23                                                                                                                    & REP.B018\\_HA1E\\_24H\\_X1\\_B23:B17\\textbar{}REP.B018\\_HA1E\\_24H\\_X2\\_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & anagrelide             & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC006\\_HA1E\\_6H:BRD-K73395020-001-01-5:10      & trt\\_cp & HA1E & K04                 & CPC006\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X4\\_B4\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_6H\\_X5\\_B4\\_DUO52HI53LO & CPC006\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X4\\_B4\\_DUO52HI53LO:K04\\textbar{}CPC006\\_HA1E\\_6H\\_X5\\_B4\\_DUO52HI53LO:K04                                                                                                                                                                                                                                                                                                                                & NA & CPC   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b24  &  0.030 &  0.02849000 & uM & 0.03 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M17                         & trt\\_cp & HA1E & M17                 & REP.B007\\_HA1E\\_24H\\_X1\\_B24                                                                                                                                             & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b22  &  0.040 &  0.04115230 & uM & 0.04 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M18                         & trt\\_cp & HA1E & M18                 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22                                                                                           & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M18\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M18\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M18                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b24  &  0.250 &  0.25641000 & uM & 0.25 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M15                         & trt\\_cp & HA1E & M15                 & REP.B007\\_HA1E\\_24H\\_X1\\_B24                                                                                                                                             & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b22  &  0.125 &  0.12345700 & uM & 0.125 uM & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M17                         & trt\\_cp & HA1E & M17                 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22                                                                                           & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M17\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M17\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M17                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b24  &  2.220 &  2.30769000 & uM & 2.22 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M13                         & trt\\_cp & HA1E & M13                 & REP.B007\\_HA1E\\_24H\\_X1\\_B24                                                                                                                                             & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b24  &  0.010 &  0.00949668 & uM & 0.01 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M18                         & trt\\_cp & HA1E & M18                 & REP.B007\\_HA1E\\_24H\\_X1\\_B24                                                                                                                                             & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b24  &  0.080 &  0.08547010 & uM & 0.08 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M16                         & trt\\_cp & HA1E & M16                 & REP.B007\\_HA1E\\_24H\\_X1\\_B24                                                                                                                                             & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b22  & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M13                         & trt\\_cp & HA1E & M13                 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22                                                                                           & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M13\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M13\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M13                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b22  &  0.370 &  0.37037000 & uM & 0.37 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M16                         & trt\\_cp & HA1E & M16                 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22                                                                                                                    & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M16\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b22  &  1.110 &  1.11111000 & uM & 1.11 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M15                         & trt\\_cp & HA1E & M15                 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22                                                                                           & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M15\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M15\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M15                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & ARP-101                & 0\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b22  &  3.330 &  3.33333000 & uM & 3.33 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.A007\\_HA1E\\_24H:M14                         & trt\\_cp & HA1E & M14                 & REP.A007\\_HA1E\\_24H\\_X1\\_B22\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22                                                                                           & REP.A007\\_HA1E\\_24H\\_X1\\_B22:M14\\textbar{}REP.A007\\_HA1E\\_24H\\_X2\\_B24:M14\\textbar{}REP.A007\\_HA1E\\_24H\\_X3\\_B22:M14                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & REP   & ARP-101                & 1\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & b24  &  0.740 &  0.76923100 & uM & 0.74 uM  & 24 h & 24 & h & HA1E & ⋯ & REP.B007\\_HA1E\\_24H:M14                         & trt\\_cp & HA1E & M14                 & REP.B007\\_HA1E\\_24H\\_X1\\_B24                                                                                                                                             & REP.B007\\_HA1E\\_24H\\_X1\\_B24:M14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            & NA & REP   & ARP-101                & 0\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & b13  &  3.330 &  3.33000000 & uM & 3.33 uM  & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:3.33  & trt\\_cp & HA1E & N20                 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13                                                                                              & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N20\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N20\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N20                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & PCLB  & AVA                    & 0\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & b13  &  0.370 &  0.37000000 & uM & 0.37 uM  & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:0.37  & trt\\_cp & HA1E & N22                 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13                                                                                              & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N22\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N22\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N22                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & PCLB  & AVA                    & 0\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & b13  &  1.110 &  1.11000000 & uM & 1.11 uM  & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:1.11  & trt\\_cp & HA1E & N21                 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13                                                                                              & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N21\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N21\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N21                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & PCLB  & AVA                    & 0\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & b13  &  0.040 &  0.04000000 & uM & 0.04 uM  & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:0.04  & trt\\_cp & HA1E & N24                 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13                                                                                              & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N24\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N24\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N24                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & PCLB  & AVA                    & 0\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & b13  & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:10    & trt\\_cp & HA1E & N19                 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13                                                                                              & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N19\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N19\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N19                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & PCLB  & AVA                    & 1\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & b13  &  0.120 &  0.12000000 & uM & 0.12 uM  & 24 h & 24 & h & HA1E & ⋯ & PCLB003\\_HA1E\\_24H:BRD-K10466330-001-01-5:0.12  & trt\\_cp & HA1E & N23                 & PCLB003\\_HA1E\\_24H\\_X1\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13                                                                                              & PCLB003\\_HA1E\\_24H\\_X1\\_B13:N23\\textbar{}PCLB003\\_HA1E\\_24H\\_X2\\_B13:N23\\textbar{}PCLB003\\_HA1E\\_24H\\_X3\\_B13:N23                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & PCLB  & AVA                    & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & f1b3 &  0.370 &  0.35000000 & uM & 0.37 uM  & 24 h & 24 & h & HA1E & ⋯ & CPC006\\_HA1E\\_24H:N13                           & trt\\_cp & HA1E & N13                 & CPC006\\_HA1E\\_24H\\_X1.A2\\_F1B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC006\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO                                                           & CPC006\\_HA1E\\_24H\\_X1.A2\\_F1B3\\_DUO52HI53LO:N13\\textbar{}CPC006\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO:N13\\textbar{}CPC006\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO:N13                                                                                                                                                                                                                                                                                                                                                                                                  & NA & CPC   & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & CPC007\\_HA1E\\_24H:BRD-K05402890-001-09-2:10     & trt\\_cp & HA1E & H03                 & CPC007\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO                                                                & CPC007\\_HA1E\\_24H\\_X1\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_24H\\_X2\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_24H\\_X3\\_B3\\_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                       & NA & CPC   & BRD-K05402890          & 1\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC007\\_HA1E\\_6H:BRD-K05402890-001-09-2:10      & trt\\_cp & HA1E & H03                 & CPC007\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO\\textbar{}CPC007\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO                                                                   & CPC007\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_6H\\_X2\\_B3\\_DUO52HI53LO:H03\\textbar{}CPC007\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                          & NA & CPC   & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b21  &  0.370 &  0.37037000 & uM & 0.37 uM  & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L04                         & trt\\_cp & HA1E & L04                 & PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21                                                                                                                    & PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L04\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L04                                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & PBIOA & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b21  &  0.125 &  0.12345700 & uM & 0.125 uM & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L05                         & trt\\_cp & HA1E & L05                 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21                                                                                           & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L05\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L05\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L05                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & PBIOA & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b21  &  3.330 &  3.33333000 & uM & 3.33 uM  & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L02                         & trt\\_cp & HA1E & L02                 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21                                                                                           & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L02\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L02\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L02                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & PBIOA & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b21  &  1.110 &  1.11111000 & uM & 1.11 uM  & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L03                         & trt\\_cp & HA1E & L03                 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21                                                                                           & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L03\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L03\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L03                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & PBIOA & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b21  & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L01                         & trt\\_cp & HA1E & L01                 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21                                                                                           & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L01\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L01\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L01                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & PBIOA & BRD-K05402890          & 0\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & b21  &  0.040 &  0.04115230 & uM & 0.04 uM  & 24 h & 24 & h & HA1E & ⋯ & PBIOA014\\_HA1E\\_24H:L06                         & trt\\_cp & HA1E & L06                 & PBIOA014\\_HA1E\\_24H\\_X1\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21                                                                                           & PBIOA014\\_HA1E\\_24H\\_X1\\_B21:L06\\textbar{}PBIOA014\\_HA1E\\_24H\\_X2\\_B21:L06\\textbar{}PBIOA014\\_HA1E\\_24H\\_X3\\_B21:L06                                                                                                                                                                                                                                                                                                                                                                                                                                  & NA & PBIOA & BRD-K05402890          & 0\\\\\n",
       "\t R-59022\\_\\_HA1E\\_\\_trt\\_cp                & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC005\\_HA1E\\_6H:BRD-K54665485-001-04-6:10      & trt\\_cp & HA1E & P15                 & CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO                                                                                                                                     & CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:P15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    & NA & CPC   & R-59022                & 0\\\\\n",
       "\t ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & b3   & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CPC005\\_HA1E\\_6H:BRD-K51476772-001-01-9:10      & trt\\_cp & HA1E & D03                 & CPC005\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO\\textbar{}CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO                                                                                                    & CPC005\\_HA1E\\_6H\\_X1\\_B3\\_DUO52HI53LO:D03\\textbar{}CPC005\\_HA1E\\_6H\\_X3\\_B3\\_DUO52HI53LO:D03                                                                                                                                                                                                                                                                                                                                                                                                                                               & NA & CPC   & ST-638                 & 0\\\\\n",
       "\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & f1b7 & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CRCGN004\\_HA1E\\_6H:BRD-K88145757-001-01-6:10    & trt\\_cp & HA1E & H15\\textbar{}I13\\textbar{}L18         & CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO                                                                                                                                 & CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO:H15\\textbar{}CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO:I13\\textbar{}CRCGN004\\_HA1E\\_6H\\_X6\\_F1B7\\_DUO52HI53LO:L18                                                                                                                                                                                                                                                                                                                                                                                              & NA & CRCGN & tributyltin            & 0\\\\\n",
       "\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & f1b4 & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & CRCGN001\\_HA1E\\_24H:BRD-K88145757-001-01-6:10   & trt\\_cp & HA1E & H15\\textbar{}I13             & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO                                                                                          & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:H15\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:I13                                                                                                                                                                                                                                                                                                                                                                                                                                     & NA & CRCGN & tributyltin            & 1\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & f1b7 & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & CRCGN004\\_HA1E\\_24H:BRD-K78683072-001-01-6:10   & trt\\_cp & HA1E & D19\\textbar{}F18\\textbar{}G07         & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO                                                    & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:G07                                                                                                                               & NA & CRCGN & triphenyl-tin          & 0\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & f1b7 & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & CRCGN004\\_HA1E\\_24H:BRD-K78683072-001-01-6:10UM & trt\\_cp & HA1E & D19\\textbar{}F18\\textbar{}G07         & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO                                                    & CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X6\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X7\\_F1B7\\_DUO52HI53LO:G07\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:D19\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:F18\\textbar{}CRCGN004\\_HA1E\\_24H\\_X8\\_F1B7\\_DUO52HI53LO:G07                                                                                                                               & NA & CRCGN & triphenyl-tin          & 0\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & f1b4 & 10.000 & 10.00000000 & uM & 10 uM    & 6 h  &  6 & h & HA1E & ⋯ & CRCGN001\\_HA1E\\_6H:BRD-K78683072-001-01-6:10    & trt\\_cp & HA1E & D19\\textbar{}F18\\textbar{}G07         & CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO                                                       & CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_6H\\_X1\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_6H\\_X2\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_6H\\_X3\\_F1B4\\_DUO52HI53LO:G07                                                                                                                                        & NA & CRCGN & triphenyl-tin          & 0\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & f1b4 & 10.000 & 10.00000000 & uM & 10 uM    & 24 h & 24 & h & HA1E & ⋯ & CRCGN001\\_HA1E\\_24H:BRD-K78683072-001-01-6:10   & trt\\_cp & HA1E & D14\\textbar{}D19\\textbar{}F18\\textbar{}G07\\textbar{}K11 & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO                                                    & CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:D14\\textbar{}CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_24H\\_X1\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:G07\\textbar{}CRCGN001\\_HA1E\\_24H\\_X2\\_F1B4\\_DUO52HI53LO:K11\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:D14\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:D19\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:F18\\textbar{}CRCGN001\\_HA1E\\_24H\\_X3\\_F1B4\\_DUO52HI53LO:G07 & NA & CRCGN & triphenyl-tin          & 0\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 52 × 36\n",
       "\n",
       "| .id &lt;chr&gt; | bead_batch &lt;chr&gt; | nearest_dose &lt;dbl&gt; | pert_dose &lt;dbl&gt; | pert_dose_unit &lt;chr&gt; | pert_idose &lt;chr&gt; | pert_itime &lt;chr&gt; | pert_time &lt;dbl&gt; | pert_time_unit &lt;chr&gt; | cell_mfc_name &lt;chr&gt; | ⋯ ⋯ | sig_id &lt;chr&gt; | pert_type &lt;chr&gt; | cell_iname &lt;chr&gt; | det_wells &lt;chr&gt; | det_plates &lt;chr&gt; | distil_ids &lt;chr&gt; | build_name &lt;lgl&gt; | project_code &lt;chr&gt; | cmap_name &lt;chr&gt; | is_ncs_exemplar &lt;int&gt; |\n",
       "|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|\n",
       "| aminomethyltransferase__HA1E__trt_cp | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | CPC001_HA1E_24H:BRD-A28318179-003-03-6:10     | trt_cp | HA1E | J07                 | CPC001_HA1E_24H_X1_B3_DUO52HI53LO|CPC001_HA1E_24H_X2_B3_DUO52HI53LO|CPC001_HA1E_24H_X3_B3_DUO52HI53LO                                                                | CPC001_HA1E_24H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X3_B3_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                       | NA | CPC   | aminomethyltransferase | 0 |\n",
       "| aminomethyltransferase__HA1E__trt_cp | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC001_HA1E_6H:BRD-A28318179-003-03-6:10      | trt_cp | HA1E | J07                 | CPC001_HA1E_6H_X1_B3_DUO52HI53LO|CPC001_HA1E_6H_X2_B3_DUO52HI53LO|CPC001_HA1E_6H_X3_B3_DUO52HI53LO                                                                   | CPC001_HA1E_6H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X3_B3_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                          | NA | CPC   | aminomethyltransferase | 1 |\n",
       "| anagrelide__HA1E__trt_cp             | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC004_HA1E_6H:BRD-K62200014-003-05-5:10      | trt_cp | HA1E | L03                 | CPC004_HA1E_6H_X1_B3_DUO52HI53LO|CPC004_HA1E_6H_X2_B3_DUO52HI53LO|CPC004_HA1E_6H_X3_B3_DUO52HI53LO                                                                   | CPC004_HA1E_6H_X1_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X2_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X3_B3_DUO52HI53LO:L03                                                                                                                                                                                                                                                                                                                                                                                                          | NA | CPC   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | f1b3 | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC011_HA1E_6H:BRD-K62200014-003-07-1:10      | trt_cp | HA1E | H10                 | CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO                                                                                                | CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO:H10|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO:H10                                                                                                                                                                                                                                                                                                                                                                                                                                           | NA | CPC   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b23  |  0.740 |  0.76923100 | uM | 0.74 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B14                         | trt_cp | HA1E | B14                 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                    | REP.B018_HA1E_24H_X1_B23:B14|REP.B018_HA1E_24H_X2_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | anagrelide             | 1 |\n",
       "| anagrelide__HA1E__trt_cp             | b24  |  1.110 |  1.11111000 | uM | 1.11 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B15                         | trt_cp | HA1E | B15                 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                           | REP.A018_HA1E_24H_X1_B24:B15|REP.A018_HA1E_24H_X2_B23:B15|REP.A018_HA1E_24H_X3_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b24  |  0.040 |  0.04115230 | uM | 0.04 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B18                         | trt_cp | HA1E | B18                 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                           | REP.A018_HA1E_24H_X1_B24:B18|REP.A018_HA1E_24H_X2_B23:B18|REP.A018_HA1E_24H_X3_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b23  |  0.080 |  0.08547010 | uM | 0.08 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B16                         | trt_cp | HA1E | B16                 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                    | REP.B018_HA1E_24H_X1_B23:B16|REP.B018_HA1E_24H_X2_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b24  | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B13                         | trt_cp | HA1E | B13                 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                           | REP.A018_HA1E_24H_X1_B24:B13|REP.A018_HA1E_24H_X2_B23:B13|REP.A018_HA1E_24H_X3_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b23  |  0.250 |  0.25641000 | uM | 0.25 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B15                         | trt_cp | HA1E | B15                 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                    | REP.B018_HA1E_24H_X1_B23:B15|REP.B018_HA1E_24H_X2_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b24  |  0.125 |  0.12345700 | uM | 0.125 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B17                         | trt_cp | HA1E | B17                 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                           | REP.A018_HA1E_24H_X1_B24:B17|REP.A018_HA1E_24H_X2_B23:B17|REP.A018_HA1E_24H_X3_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b23  |  0.010 |  0.00949668 | uM | 0.01 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B18                         | trt_cp | HA1E | B18                 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                    | REP.B018_HA1E_24H_X1_B23:B18|REP.B018_HA1E_24H_X2_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b24  |  0.370 |  0.37037000 | uM | 0.37 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B16                         | trt_cp | HA1E | B16                 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                           | REP.A018_HA1E_24H_X1_B24:B16|REP.A018_HA1E_24H_X2_B23:B16|REP.A018_HA1E_24H_X3_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b24  |  3.330 |  3.33333000 | uM | 3.33 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A018_HA1E_24H:B14                         | trt_cp | HA1E | B14                 | REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                           | REP.A018_HA1E_24H_X1_B24:B14|REP.A018_HA1E_24H_X2_B23:B14|REP.A018_HA1E_24H_X3_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b23  |  2.220 |  2.30769000 | uM | 2.22 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B13                         | trt_cp | HA1E | B13                 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                    | REP.B018_HA1E_24H_X1_B23:B13|REP.B018_HA1E_24H_X2_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | anagrelide             | 0 |\n",
       "| anagrelide__HA1E__trt_cp             | b23  |  0.030 |  0.02849000 | uM | 0.03 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B018_HA1E_24H:B17                         | trt_cp | HA1E | B17                 | REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                    | REP.B018_HA1E_24H_X1_B23:B17|REP.B018_HA1E_24H_X2_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | anagrelide             | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC006_HA1E_6H:BRD-K73395020-001-01-5:10      | trt_cp | HA1E | K04                 | CPC006_HA1E_6H_X1_B3_DUO52HI53LO|CPC006_HA1E_6H_X2_B3_DUO52HI53LO|CPC006_HA1E_6H_X3_B3_DUO52HI53LO|CPC006_HA1E_6H_X4_B4_DUO52HI53LO|CPC006_HA1E_6H_X5_B4_DUO52HI53LO | CPC006_HA1E_6H_X1_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X2_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X3_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X4_B4_DUO52HI53LO:K04|CPC006_HA1E_6H_X5_B4_DUO52HI53LO:K04                                                                                                                                                                                                                                                                                                                                | NA | CPC   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b24  |  0.030 |  0.02849000 | uM | 0.03 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M17                         | trt_cp | HA1E | M17                 | REP.B007_HA1E_24H_X1_B24                                                                                                                                             | REP.B007_HA1E_24H_X1_B24:M17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b22  |  0.040 |  0.04115230 | uM | 0.04 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M18                         | trt_cp | HA1E | M18                 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                           | REP.A007_HA1E_24H_X1_B22:M18|REP.A007_HA1E_24H_X2_B24:M18|REP.A007_HA1E_24H_X3_B22:M18                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b24  |  0.250 |  0.25641000 | uM | 0.25 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M15                         | trt_cp | HA1E | M15                 | REP.B007_HA1E_24H_X1_B24                                                                                                                                             | REP.B007_HA1E_24H_X1_B24:M15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b22  |  0.125 |  0.12345700 | uM | 0.125 uM | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M17                         | trt_cp | HA1E | M17                 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                           | REP.A007_HA1E_24H_X1_B22:M17|REP.A007_HA1E_24H_X2_B24:M17|REP.A007_HA1E_24H_X3_B22:M17                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b24  |  2.220 |  2.30769000 | uM | 2.22 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M13                         | trt_cp | HA1E | M13                 | REP.B007_HA1E_24H_X1_B24                                                                                                                                             | REP.B007_HA1E_24H_X1_B24:M13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b24  |  0.010 |  0.00949668 | uM | 0.01 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M18                         | trt_cp | HA1E | M18                 | REP.B007_HA1E_24H_X1_B24                                                                                                                                             | REP.B007_HA1E_24H_X1_B24:M18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b24  |  0.080 |  0.08547010 | uM | 0.08 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M16                         | trt_cp | HA1E | M16                 | REP.B007_HA1E_24H_X1_B24                                                                                                                                             | REP.B007_HA1E_24H_X1_B24:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b22  | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M13                         | trt_cp | HA1E | M13                 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                           | REP.A007_HA1E_24H_X1_B22:M13|REP.A007_HA1E_24H_X2_B24:M13|REP.A007_HA1E_24H_X3_B22:M13                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b22  |  0.370 |  0.37037000 | uM | 0.37 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M16                         | trt_cp | HA1E | M16                 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X3_B22                                                                                                                    | REP.A007_HA1E_24H_X1_B22:M16|REP.A007_HA1E_24H_X3_B22:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b22  |  1.110 |  1.11111000 | uM | 1.11 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M15                         | trt_cp | HA1E | M15                 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                           | REP.A007_HA1E_24H_X1_B22:M15|REP.A007_HA1E_24H_X2_B24:M15|REP.A007_HA1E_24H_X3_B22:M15                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | ARP-101                | 0 |\n",
       "| ARP-101__HA1E__trt_cp                | b22  |  3.330 |  3.33333000 | uM | 3.33 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.A007_HA1E_24H:M14                         | trt_cp | HA1E | M14                 | REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                           | REP.A007_HA1E_24H_X1_B22:M14|REP.A007_HA1E_24H_X2_B24:M14|REP.A007_HA1E_24H_X3_B22:M14                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | REP   | ARP-101                | 1 |\n",
       "| ARP-101__HA1E__trt_cp                | b24  |  0.740 |  0.76923100 | uM | 0.74 uM  | 24 h | 24 | h | HA1E | ⋯ | REP.B007_HA1E_24H:M14                         | trt_cp | HA1E | M14                 | REP.B007_HA1E_24H_X1_B24                                                                                                                                             | REP.B007_HA1E_24H_X1_B24:M14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | NA | REP   | ARP-101                | 0 |\n",
       "| AVA__HA1E__trt_cp                    | b13  |  3.330 |  3.33000000 | uM | 3.33 uM  | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:3.33  | trt_cp | HA1E | N20                 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                              | PCLB003_HA1E_24H_X1_B13:N20|PCLB003_HA1E_24H_X2_B13:N20|PCLB003_HA1E_24H_X3_B13:N20                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | PCLB  | AVA                    | 0 |\n",
       "| AVA__HA1E__trt_cp                    | b13  |  0.370 |  0.37000000 | uM | 0.37 uM  | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.37  | trt_cp | HA1E | N22                 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                              | PCLB003_HA1E_24H_X1_B13:N22|PCLB003_HA1E_24H_X2_B13:N22|PCLB003_HA1E_24H_X3_B13:N22                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | PCLB  | AVA                    | 0 |\n",
       "| AVA__HA1E__trt_cp                    | b13  |  1.110 |  1.11000000 | uM | 1.11 uM  | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:1.11  | trt_cp | HA1E | N21                 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                              | PCLB003_HA1E_24H_X1_B13:N21|PCLB003_HA1E_24H_X2_B13:N21|PCLB003_HA1E_24H_X3_B13:N21                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | PCLB  | AVA                    | 0 |\n",
       "| AVA__HA1E__trt_cp                    | b13  |  0.040 |  0.04000000 | uM | 0.04 uM  | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.04  | trt_cp | HA1E | N24                 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                              | PCLB003_HA1E_24H_X1_B13:N24|PCLB003_HA1E_24H_X2_B13:N24|PCLB003_HA1E_24H_X3_B13:N24                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | PCLB  | AVA                    | 0 |\n",
       "| AVA__HA1E__trt_cp                    | b13  | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:10    | trt_cp | HA1E | N19                 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                              | PCLB003_HA1E_24H_X1_B13:N19|PCLB003_HA1E_24H_X2_B13:N19|PCLB003_HA1E_24H_X3_B13:N19                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | PCLB  | AVA                    | 1 |\n",
       "| AVA__HA1E__trt_cp                    | b13  |  0.120 |  0.12000000 | uM | 0.12 uM  | 24 h | 24 | h | HA1E | ⋯ | PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.12  | trt_cp | HA1E | N23                 | PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                              | PCLB003_HA1E_24H_X1_B13:N23|PCLB003_HA1E_24H_X2_B13:N23|PCLB003_HA1E_24H_X3_B13:N23                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | PCLB  | AVA                    | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | f1b3 |  0.370 |  0.35000000 | uM | 0.37 uM  | 24 h | 24 | h | HA1E | ⋯ | CPC006_HA1E_24H:N13                           | trt_cp | HA1E | N13                 | CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO|CPC006_HA1E_24H_X2_B3_DUO52HI53LO|CPC006_HA1E_24H_X3_B3_DUO52HI53LO                                                           | CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X2_B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X3_B3_DUO52HI53LO:N13                                                                                                                                                                                                                                                                                                                                                                                                  | NA | CPC   | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | CPC007_HA1E_24H:BRD-K05402890-001-09-2:10     | trt_cp | HA1E | H03                 | CPC007_HA1E_24H_X1_B3_DUO52HI53LO|CPC007_HA1E_24H_X2_B3_DUO52HI53LO|CPC007_HA1E_24H_X3_B3_DUO52HI53LO                                                                | CPC007_HA1E_24H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X3_B3_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                       | NA | CPC   | BRD-K05402890          | 1 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC007_HA1E_6H:BRD-K05402890-001-09-2:10      | trt_cp | HA1E | H03                 | CPC007_HA1E_6H_X1_B3_DUO52HI53LO|CPC007_HA1E_6H_X2_B3_DUO52HI53LO|CPC007_HA1E_6H_X3_B3_DUO52HI53LO                                                                   | CPC007_HA1E_6H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X3_B3_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                          | NA | CPC   | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b21  |  0.370 |  0.37037000 | uM | 0.37 uM  | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L04                         | trt_cp | HA1E | L04                 | PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                                                    | PBIOA014_HA1E_24H_X2_B21:L04|PBIOA014_HA1E_24H_X3_B21:L04                                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | PBIOA | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b21  |  0.125 |  0.12345700 | uM | 0.125 uM | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L05                         | trt_cp | HA1E | L05                 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                           | PBIOA014_HA1E_24H_X1_B21:L05|PBIOA014_HA1E_24H_X2_B21:L05|PBIOA014_HA1E_24H_X3_B21:L05                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | PBIOA | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b21  |  3.330 |  3.33333000 | uM | 3.33 uM  | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L02                         | trt_cp | HA1E | L02                 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                           | PBIOA014_HA1E_24H_X1_B21:L02|PBIOA014_HA1E_24H_X2_B21:L02|PBIOA014_HA1E_24H_X3_B21:L02                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | PBIOA | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b21  |  1.110 |  1.11111000 | uM | 1.11 uM  | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L03                         | trt_cp | HA1E | L03                 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                           | PBIOA014_HA1E_24H_X1_B21:L03|PBIOA014_HA1E_24H_X2_B21:L03|PBIOA014_HA1E_24H_X3_B21:L03                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | PBIOA | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b21  | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L01                         | trt_cp | HA1E | L01                 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                           | PBIOA014_HA1E_24H_X1_B21:L01|PBIOA014_HA1E_24H_X2_B21:L01|PBIOA014_HA1E_24H_X3_B21:L01                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | PBIOA | BRD-K05402890          | 0 |\n",
       "| BRD-K05402890__HA1E__trt_cp          | b21  |  0.040 |  0.04115230 | uM | 0.04 uM  | 24 h | 24 | h | HA1E | ⋯ | PBIOA014_HA1E_24H:L06                         | trt_cp | HA1E | L06                 | PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                           | PBIOA014_HA1E_24H_X1_B21:L06|PBIOA014_HA1E_24H_X2_B21:L06|PBIOA014_HA1E_24H_X3_B21:L06                                                                                                                                                                                                                                                                                                                                                                                                                                  | NA | PBIOA | BRD-K05402890          | 0 |\n",
       "| R-59022__HA1E__trt_cp                | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC005_HA1E_6H:BRD-K54665485-001-04-6:10      | trt_cp | HA1E | P15                 | CPC005_HA1E_6H_X3_B3_DUO52HI53LO                                                                                                                                     | CPC005_HA1E_6H_X3_B3_DUO52HI53LO:P15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | NA | CPC   | R-59022                | 0 |\n",
       "| ST-638__HA1E__trt_cp                 | b3   | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CPC005_HA1E_6H:BRD-K51476772-001-01-9:10      | trt_cp | HA1E | D03                 | CPC005_HA1E_6H_X1_B3_DUO52HI53LO|CPC005_HA1E_6H_X3_B3_DUO52HI53LO                                                                                                    | CPC005_HA1E_6H_X1_B3_DUO52HI53LO:D03|CPC005_HA1E_6H_X3_B3_DUO52HI53LO:D03                                                                                                                                                                                                                                                                                                                                                                                                                                               | NA | CPC   | ST-638                 | 0 |\n",
       "| tributyltin__HA1E__trt_cp            | f1b7 | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CRCGN004_HA1E_6H:BRD-K88145757-001-01-6:10    | trt_cp | HA1E | H15|I13|L18         | CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO                                                                                                                                 | CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:H15|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:I13|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:L18                                                                                                                                                                                                                                                                                                                                                                                              | NA | CRCGN | tributyltin            | 0 |\n",
       "| tributyltin__HA1E__trt_cp            | f1b4 | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | CRCGN001_HA1E_24H:BRD-K88145757-001-01-6:10   | trt_cp | HA1E | H15|I13             | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO                                                                                          | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:H15|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:I13                                                                                                                                                                                                                                                                                                                                                                                                                                     | NA | CRCGN | tributyltin            | 1 |\n",
       "| triphenyl-tin__HA1E__trt_cp          | f1b7 | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10   | trt_cp | HA1E | D19|F18|G07         | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO                                                    | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07                                                                                                                               | NA | CRCGN | triphenyl-tin          | 0 |\n",
       "| triphenyl-tin__HA1E__trt_cp          | f1b7 | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10UM | trt_cp | HA1E | D19|F18|G07         | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO                                                    | CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07                                                                                                                               | NA | CRCGN | triphenyl-tin          | 0 |\n",
       "| triphenyl-tin__HA1E__trt_cp          | f1b4 | 10.000 | 10.00000000 | uM | 10 uM    | 6 h  |  6 | h | HA1E | ⋯ | CRCGN001_HA1E_6H:BRD-K78683072-001-01-6:10    | trt_cp | HA1E | D19|F18|G07         | CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO                                                       | CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:G07                                                                                                                                        | NA | CRCGN | triphenyl-tin          | 0 |\n",
       "| triphenyl-tin__HA1E__trt_cp          | f1b4 | 10.000 | 10.00000000 | uM | 10 uM    | 24 h | 24 | h | HA1E | ⋯ | CRCGN001_HA1E_24H:BRD-K78683072-001-01-6:10   | trt_cp | HA1E | D14|D19|F18|G07|K11 | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO                                                    | CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:K11|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:G07 | NA | CRCGN | triphenyl-tin          | 0 |\n",
       "\n"
      ],
      "text/plain": [
       "   .id                                  bead_batch nearest_dose pert_dose  \n",
       "1  aminomethyltransferase__HA1E__trt_cp b3         10.000       10.00000000\n",
       "2  aminomethyltransferase__HA1E__trt_cp b3         10.000       10.00000000\n",
       "3  anagrelide__HA1E__trt_cp             b3         10.000       10.00000000\n",
       "4  anagrelide__HA1E__trt_cp             f1b3       10.000       10.00000000\n",
       "5  anagrelide__HA1E__trt_cp             b23         0.740        0.76923100\n",
       "6  anagrelide__HA1E__trt_cp             b24         1.110        1.11111000\n",
       "7  anagrelide__HA1E__trt_cp             b24         0.040        0.04115230\n",
       "8  anagrelide__HA1E__trt_cp             b23         0.080        0.08547010\n",
       "9  anagrelide__HA1E__trt_cp             b24        10.000       10.00000000\n",
       "10 anagrelide__HA1E__trt_cp             b23         0.250        0.25641000\n",
       "11 anagrelide__HA1E__trt_cp             b24         0.125        0.12345700\n",
       "12 anagrelide__HA1E__trt_cp             b23         0.010        0.00949668\n",
       "13 anagrelide__HA1E__trt_cp             b24         0.370        0.37037000\n",
       "14 anagrelide__HA1E__trt_cp             b24         3.330        3.33333000\n",
       "15 anagrelide__HA1E__trt_cp             b23         2.220        2.30769000\n",
       "16 anagrelide__HA1E__trt_cp             b23         0.030        0.02849000\n",
       "17 ARP-101__HA1E__trt_cp                b3         10.000       10.00000000\n",
       "18 ARP-101__HA1E__trt_cp                b24         0.030        0.02849000\n",
       "19 ARP-101__HA1E__trt_cp                b22         0.040        0.04115230\n",
       "20 ARP-101__HA1E__trt_cp                b24         0.250        0.25641000\n",
       "21 ARP-101__HA1E__trt_cp                b22         0.125        0.12345700\n",
       "22 ARP-101__HA1E__trt_cp                b24         2.220        2.30769000\n",
       "23 ARP-101__HA1E__trt_cp                b24         0.010        0.00949668\n",
       "24 ARP-101__HA1E__trt_cp                b24         0.080        0.08547010\n",
       "25 ARP-101__HA1E__trt_cp                b22        10.000       10.00000000\n",
       "26 ARP-101__HA1E__trt_cp                b22         0.370        0.37037000\n",
       "27 ARP-101__HA1E__trt_cp                b22         1.110        1.11111000\n",
       "28 ARP-101__HA1E__trt_cp                b22         3.330        3.33333000\n",
       "29 ARP-101__HA1E__trt_cp                b24         0.740        0.76923100\n",
       "30 AVA__HA1E__trt_cp                    b13         3.330        3.33000000\n",
       "31 AVA__HA1E__trt_cp                    b13         0.370        0.37000000\n",
       "32 AVA__HA1E__trt_cp                    b13         1.110        1.11000000\n",
       "33 AVA__HA1E__trt_cp                    b13         0.040        0.04000000\n",
       "34 AVA__HA1E__trt_cp                    b13        10.000       10.00000000\n",
       "35 AVA__HA1E__trt_cp                    b13         0.120        0.12000000\n",
       "36 BRD-K05402890__HA1E__trt_cp          f1b3        0.370        0.35000000\n",
       "37 BRD-K05402890__HA1E__trt_cp          b3         10.000       10.00000000\n",
       "38 BRD-K05402890__HA1E__trt_cp          b3         10.000       10.00000000\n",
       "39 BRD-K05402890__HA1E__trt_cp          b21         0.370        0.37037000\n",
       "40 BRD-K05402890__HA1E__trt_cp          b21         0.125        0.12345700\n",
       "41 BRD-K05402890__HA1E__trt_cp          b21         3.330        3.33333000\n",
       "42 BRD-K05402890__HA1E__trt_cp          b21         1.110        1.11111000\n",
       "43 BRD-K05402890__HA1E__trt_cp          b21        10.000       10.00000000\n",
       "44 BRD-K05402890__HA1E__trt_cp          b21         0.040        0.04115230\n",
       "45 R-59022__HA1E__trt_cp                b3         10.000       10.00000000\n",
       "46 ST-638__HA1E__trt_cp                 b3         10.000       10.00000000\n",
       "47 tributyltin__HA1E__trt_cp            f1b7       10.000       10.00000000\n",
       "48 tributyltin__HA1E__trt_cp            f1b4       10.000       10.00000000\n",
       "49 triphenyl-tin__HA1E__trt_cp          f1b7       10.000       10.00000000\n",
       "50 triphenyl-tin__HA1E__trt_cp          f1b7       10.000       10.00000000\n",
       "51 triphenyl-tin__HA1E__trt_cp          f1b4       10.000       10.00000000\n",
       "52 triphenyl-tin__HA1E__trt_cp          f1b4       10.000       10.00000000\n",
       "   pert_dose_unit pert_idose pert_itime pert_time pert_time_unit cell_mfc_name\n",
       "1  uM             10 uM      24 h       24        h              HA1E         \n",
       "2  uM             10 uM      6 h         6        h              HA1E         \n",
       "3  uM             10 uM      6 h         6        h              HA1E         \n",
       "4  uM             10 uM      6 h         6        h              HA1E         \n",
       "5  uM             0.74 uM    24 h       24        h              HA1E         \n",
       "6  uM             1.11 uM    24 h       24        h              HA1E         \n",
       "7  uM             0.04 uM    24 h       24        h              HA1E         \n",
       "8  uM             0.08 uM    24 h       24        h              HA1E         \n",
       "9  uM             10 uM      24 h       24        h              HA1E         \n",
       "10 uM             0.25 uM    24 h       24        h              HA1E         \n",
       "11 uM             0.125 uM   24 h       24        h              HA1E         \n",
       "12 uM             0.01 uM    24 h       24        h              HA1E         \n",
       "13 uM             0.37 uM    24 h       24        h              HA1E         \n",
       "14 uM             3.33 uM    24 h       24        h              HA1E         \n",
       "15 uM             2.22 uM    24 h       24        h              HA1E         \n",
       "16 uM             0.03 uM    24 h       24        h              HA1E         \n",
       "17 uM             10 uM      6 h         6        h              HA1E         \n",
       "18 uM             0.03 uM    24 h       24        h              HA1E         \n",
       "19 uM             0.04 uM    24 h       24        h              HA1E         \n",
       "20 uM             0.25 uM    24 h       24        h              HA1E         \n",
       "21 uM             0.125 uM   24 h       24        h              HA1E         \n",
       "22 uM             2.22 uM    24 h       24        h              HA1E         \n",
       "23 uM             0.01 uM    24 h       24        h              HA1E         \n",
       "24 uM             0.08 uM    24 h       24        h              HA1E         \n",
       "25 uM             10 uM      24 h       24        h              HA1E         \n",
       "26 uM             0.37 uM    24 h       24        h              HA1E         \n",
       "27 uM             1.11 uM    24 h       24        h              HA1E         \n",
       "28 uM             3.33 uM    24 h       24        h              HA1E         \n",
       "29 uM             0.74 uM    24 h       24        h              HA1E         \n",
       "30 uM             3.33 uM    24 h       24        h              HA1E         \n",
       "31 uM             0.37 uM    24 h       24        h              HA1E         \n",
       "32 uM             1.11 uM    24 h       24        h              HA1E         \n",
       "33 uM             0.04 uM    24 h       24        h              HA1E         \n",
       "34 uM             10 uM      24 h       24        h              HA1E         \n",
       "35 uM             0.12 uM    24 h       24        h              HA1E         \n",
       "36 uM             0.37 uM    24 h       24        h              HA1E         \n",
       "37 uM             10 uM      24 h       24        h              HA1E         \n",
       "38 uM             10 uM      6 h         6        h              HA1E         \n",
       "39 uM             0.37 uM    24 h       24        h              HA1E         \n",
       "40 uM             0.125 uM   24 h       24        h              HA1E         \n",
       "41 uM             3.33 uM    24 h       24        h              HA1E         \n",
       "42 uM             1.11 uM    24 h       24        h              HA1E         \n",
       "43 uM             10 uM      24 h       24        h              HA1E         \n",
       "44 uM             0.04 uM    24 h       24        h              HA1E         \n",
       "45 uM             10 uM      6 h         6        h              HA1E         \n",
       "46 uM             10 uM      6 h         6        h              HA1E         \n",
       "47 uM             10 uM      6 h         6        h              HA1E         \n",
       "48 uM             10 uM      24 h       24        h              HA1E         \n",
       "49 uM             10 uM      24 h       24        h              HA1E         \n",
       "50 uM             10 uM      24 h       24        h              HA1E         \n",
       "51 uM             10 uM      6 h         6        h              HA1E         \n",
       "52 uM             10 uM      24 h       24        h              HA1E         \n",
       "   ⋯ sig_id                                        pert_type cell_iname\n",
       "1  ⋯ CPC001_HA1E_24H:BRD-A28318179-003-03-6:10     trt_cp    HA1E      \n",
       "2  ⋯ CPC001_HA1E_6H:BRD-A28318179-003-03-6:10      trt_cp    HA1E      \n",
       "3  ⋯ CPC004_HA1E_6H:BRD-K62200014-003-05-5:10      trt_cp    HA1E      \n",
       "4  ⋯ CPC011_HA1E_6H:BRD-K62200014-003-07-1:10      trt_cp    HA1E      \n",
       "5  ⋯ REP.B018_HA1E_24H:B14                         trt_cp    HA1E      \n",
       "6  ⋯ REP.A018_HA1E_24H:B15                         trt_cp    HA1E      \n",
       "7  ⋯ REP.A018_HA1E_24H:B18                         trt_cp    HA1E      \n",
       "8  ⋯ REP.B018_HA1E_24H:B16                         trt_cp    HA1E      \n",
       "9  ⋯ REP.A018_HA1E_24H:B13                         trt_cp    HA1E      \n",
       "10 ⋯ REP.B018_HA1E_24H:B15                         trt_cp    HA1E      \n",
       "11 ⋯ REP.A018_HA1E_24H:B17                         trt_cp    HA1E      \n",
       "12 ⋯ REP.B018_HA1E_24H:B18                         trt_cp    HA1E      \n",
       "13 ⋯ REP.A018_HA1E_24H:B16                         trt_cp    HA1E      \n",
       "14 ⋯ REP.A018_HA1E_24H:B14                         trt_cp    HA1E      \n",
       "15 ⋯ REP.B018_HA1E_24H:B13                         trt_cp    HA1E      \n",
       "16 ⋯ REP.B018_HA1E_24H:B17                         trt_cp    HA1E      \n",
       "17 ⋯ CPC006_HA1E_6H:BRD-K73395020-001-01-5:10      trt_cp    HA1E      \n",
       "18 ⋯ REP.B007_HA1E_24H:M17                         trt_cp    HA1E      \n",
       "19 ⋯ REP.A007_HA1E_24H:M18                         trt_cp    HA1E      \n",
       "20 ⋯ REP.B007_HA1E_24H:M15                         trt_cp    HA1E      \n",
       "21 ⋯ REP.A007_HA1E_24H:M17                         trt_cp    HA1E      \n",
       "22 ⋯ REP.B007_HA1E_24H:M13                         trt_cp    HA1E      \n",
       "23 ⋯ REP.B007_HA1E_24H:M18                         trt_cp    HA1E      \n",
       "24 ⋯ REP.B007_HA1E_24H:M16                         trt_cp    HA1E      \n",
       "25 ⋯ REP.A007_HA1E_24H:M13                         trt_cp    HA1E      \n",
       "26 ⋯ REP.A007_HA1E_24H:M16                         trt_cp    HA1E      \n",
       "27 ⋯ REP.A007_HA1E_24H:M15                         trt_cp    HA1E      \n",
       "28 ⋯ REP.A007_HA1E_24H:M14                         trt_cp    HA1E      \n",
       "29 ⋯ REP.B007_HA1E_24H:M14                         trt_cp    HA1E      \n",
       "30 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:3.33  trt_cp    HA1E      \n",
       "31 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.37  trt_cp    HA1E      \n",
       "32 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:1.11  trt_cp    HA1E      \n",
       "33 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.04  trt_cp    HA1E      \n",
       "34 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:10    trt_cp    HA1E      \n",
       "35 ⋯ PCLB003_HA1E_24H:BRD-K10466330-001-01-5:0.12  trt_cp    HA1E      \n",
       "36 ⋯ CPC006_HA1E_24H:N13                           trt_cp    HA1E      \n",
       "37 ⋯ CPC007_HA1E_24H:BRD-K05402890-001-09-2:10     trt_cp    HA1E      \n",
       "38 ⋯ CPC007_HA1E_6H:BRD-K05402890-001-09-2:10      trt_cp    HA1E      \n",
       "39 ⋯ PBIOA014_HA1E_24H:L04                         trt_cp    HA1E      \n",
       "40 ⋯ PBIOA014_HA1E_24H:L05                         trt_cp    HA1E      \n",
       "41 ⋯ PBIOA014_HA1E_24H:L02                         trt_cp    HA1E      \n",
       "42 ⋯ PBIOA014_HA1E_24H:L03                         trt_cp    HA1E      \n",
       "43 ⋯ PBIOA014_HA1E_24H:L01                         trt_cp    HA1E      \n",
       "44 ⋯ PBIOA014_HA1E_24H:L06                         trt_cp    HA1E      \n",
       "45 ⋯ CPC005_HA1E_6H:BRD-K54665485-001-04-6:10      trt_cp    HA1E      \n",
       "46 ⋯ CPC005_HA1E_6H:BRD-K51476772-001-01-9:10      trt_cp    HA1E      \n",
       "47 ⋯ CRCGN004_HA1E_6H:BRD-K88145757-001-01-6:10    trt_cp    HA1E      \n",
       "48 ⋯ CRCGN001_HA1E_24H:BRD-K88145757-001-01-6:10   trt_cp    HA1E      \n",
       "49 ⋯ CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10   trt_cp    HA1E      \n",
       "50 ⋯ CRCGN004_HA1E_24H:BRD-K78683072-001-01-6:10UM trt_cp    HA1E      \n",
       "51 ⋯ CRCGN001_HA1E_6H:BRD-K78683072-001-01-6:10    trt_cp    HA1E      \n",
       "52 ⋯ CRCGN001_HA1E_24H:BRD-K78683072-001-01-6:10   trt_cp    HA1E      \n",
       "   det_wells          \n",
       "1  J07                \n",
       "2  J07                \n",
       "3  L03                \n",
       "4  H10                \n",
       "5  B14                \n",
       "6  B15                \n",
       "7  B18                \n",
       "8  B16                \n",
       "9  B13                \n",
       "10 B15                \n",
       "11 B17                \n",
       "12 B18                \n",
       "13 B16                \n",
       "14 B14                \n",
       "15 B13                \n",
       "16 B17                \n",
       "17 K04                \n",
       "18 M17                \n",
       "19 M18                \n",
       "20 M15                \n",
       "21 M17                \n",
       "22 M13                \n",
       "23 M18                \n",
       "24 M16                \n",
       "25 M13                \n",
       "26 M16                \n",
       "27 M15                \n",
       "28 M14                \n",
       "29 M14                \n",
       "30 N20                \n",
       "31 N22                \n",
       "32 N21                \n",
       "33 N24                \n",
       "34 N19                \n",
       "35 N23                \n",
       "36 N13                \n",
       "37 H03                \n",
       "38 H03                \n",
       "39 L04                \n",
       "40 L05                \n",
       "41 L02                \n",
       "42 L03                \n",
       "43 L01                \n",
       "44 L06                \n",
       "45 P15                \n",
       "46 D03                \n",
       "47 H15|I13|L18        \n",
       "48 H15|I13            \n",
       "49 D19|F18|G07        \n",
       "50 D19|F18|G07        \n",
       "51 D19|F18|G07        \n",
       "52 D14|D19|F18|G07|K11\n",
       "   det_plates                                                                                                                                                          \n",
       "1  CPC001_HA1E_24H_X1_B3_DUO52HI53LO|CPC001_HA1E_24H_X2_B3_DUO52HI53LO|CPC001_HA1E_24H_X3_B3_DUO52HI53LO                                                               \n",
       "2  CPC001_HA1E_6H_X1_B3_DUO52HI53LO|CPC001_HA1E_6H_X2_B3_DUO52HI53LO|CPC001_HA1E_6H_X3_B3_DUO52HI53LO                                                                  \n",
       "3  CPC004_HA1E_6H_X1_B3_DUO52HI53LO|CPC004_HA1E_6H_X2_B3_DUO52HI53LO|CPC004_HA1E_6H_X3_B3_DUO52HI53LO                                                                  \n",
       "4  CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO                                                                                               \n",
       "5  REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   \n",
       "6  REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          \n",
       "7  REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          \n",
       "8  REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   \n",
       "9  REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          \n",
       "10 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   \n",
       "11 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          \n",
       "12 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   \n",
       "13 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          \n",
       "14 REP.A018_HA1E_24H_X1_B24|REP.A018_HA1E_24H_X2_B23|REP.A018_HA1E_24H_X3_B23                                                                                          \n",
       "15 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   \n",
       "16 REP.B018_HA1E_24H_X1_B23|REP.B018_HA1E_24H_X2_B23                                                                                                                   \n",
       "17 CPC006_HA1E_6H_X1_B3_DUO52HI53LO|CPC006_HA1E_6H_X2_B3_DUO52HI53LO|CPC006_HA1E_6H_X3_B3_DUO52HI53LO|CPC006_HA1E_6H_X4_B4_DUO52HI53LO|CPC006_HA1E_6H_X5_B4_DUO52HI53LO\n",
       "18 REP.B007_HA1E_24H_X1_B24                                                                                                                                            \n",
       "19 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          \n",
       "20 REP.B007_HA1E_24H_X1_B24                                                                                                                                            \n",
       "21 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          \n",
       "22 REP.B007_HA1E_24H_X1_B24                                                                                                                                            \n",
       "23 REP.B007_HA1E_24H_X1_B24                                                                                                                                            \n",
       "24 REP.B007_HA1E_24H_X1_B24                                                                                                                                            \n",
       "25 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          \n",
       "26 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X3_B22                                                                                                                   \n",
       "27 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          \n",
       "28 REP.A007_HA1E_24H_X1_B22|REP.A007_HA1E_24H_X2_B24|REP.A007_HA1E_24H_X3_B22                                                                                          \n",
       "29 REP.B007_HA1E_24H_X1_B24                                                                                                                                            \n",
       "30 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             \n",
       "31 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             \n",
       "32 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             \n",
       "33 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             \n",
       "34 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             \n",
       "35 PCLB003_HA1E_24H_X1_B13|PCLB003_HA1E_24H_X2_B13|PCLB003_HA1E_24H_X3_B13                                                                                             \n",
       "36 CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO|CPC006_HA1E_24H_X2_B3_DUO52HI53LO|CPC006_HA1E_24H_X3_B3_DUO52HI53LO                                                          \n",
       "37 CPC007_HA1E_24H_X1_B3_DUO52HI53LO|CPC007_HA1E_24H_X2_B3_DUO52HI53LO|CPC007_HA1E_24H_X3_B3_DUO52HI53LO                                                               \n",
       "38 CPC007_HA1E_6H_X1_B3_DUO52HI53LO|CPC007_HA1E_6H_X2_B3_DUO52HI53LO|CPC007_HA1E_6H_X3_B3_DUO52HI53LO                                                                  \n",
       "39 PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                                                   \n",
       "40 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          \n",
       "41 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          \n",
       "42 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          \n",
       "43 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          \n",
       "44 PBIOA014_HA1E_24H_X1_B21|PBIOA014_HA1E_24H_X2_B21|PBIOA014_HA1E_24H_X3_B21                                                                                          \n",
       "45 CPC005_HA1E_6H_X3_B3_DUO52HI53LO                                                                                                                                    \n",
       "46 CPC005_HA1E_6H_X1_B3_DUO52HI53LO|CPC005_HA1E_6H_X3_B3_DUO52HI53LO                                                                                                   \n",
       "47 CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO                                                                                                                                \n",
       "48 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO                                                                                         \n",
       "49 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO                                                   \n",
       "50 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO                                                   \n",
       "51 CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO                                                      \n",
       "52 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO                                                   \n",
       "   distil_ids                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             \n",
       "1  CPC001_HA1E_24H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_24H_X3_B3_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                      \n",
       "2  CPC001_HA1E_6H_X1_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X2_B3_DUO52HI53LO:J07|CPC001_HA1E_6H_X3_B3_DUO52HI53LO:J07                                                                                                                                                                                                                                                                                                                                                                                                         \n",
       "3  CPC004_HA1E_6H_X1_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X2_B3_DUO52HI53LO:L03|CPC004_HA1E_6H_X3_B3_DUO52HI53LO:L03                                                                                                                                                                                                                                                                                                                                                                                                         \n",
       "4  CPC011_HA1E_6H_X1_F1B3_DUO52HI53LO:H10|CPC011_HA1E_6H_X3_F1B3_DUO52HI53LO:H10                                                                                                                                                                                                                                                                                                                                                                                                                                          \n",
       "5  REP.B018_HA1E_24H_X1_B23:B14|REP.B018_HA1E_24H_X2_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "6  REP.A018_HA1E_24H_X1_B24:B15|REP.A018_HA1E_24H_X2_B23:B15|REP.A018_HA1E_24H_X3_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "7  REP.A018_HA1E_24H_X1_B24:B18|REP.A018_HA1E_24H_X2_B23:B18|REP.A018_HA1E_24H_X3_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "8  REP.B018_HA1E_24H_X1_B23:B16|REP.B018_HA1E_24H_X2_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "9  REP.A018_HA1E_24H_X1_B24:B13|REP.A018_HA1E_24H_X2_B23:B13|REP.A018_HA1E_24H_X3_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "10 REP.B018_HA1E_24H_X1_B23:B15|REP.B018_HA1E_24H_X2_B23:B15                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "11 REP.A018_HA1E_24H_X1_B24:B17|REP.A018_HA1E_24H_X2_B23:B17|REP.A018_HA1E_24H_X3_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "12 REP.B018_HA1E_24H_X1_B23:B18|REP.B018_HA1E_24H_X2_B23:B18                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "13 REP.A018_HA1E_24H_X1_B24:B16|REP.A018_HA1E_24H_X2_B23:B16|REP.A018_HA1E_24H_X3_B23:B16                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "14 REP.A018_HA1E_24H_X1_B24:B14|REP.A018_HA1E_24H_X2_B23:B14|REP.A018_HA1E_24H_X3_B23:B14                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "15 REP.B018_HA1E_24H_X1_B23:B13|REP.B018_HA1E_24H_X2_B23:B13                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "16 REP.B018_HA1E_24H_X1_B23:B17|REP.B018_HA1E_24H_X2_B23:B17                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "17 CPC006_HA1E_6H_X1_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X2_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X3_B3_DUO52HI53LO:K04|CPC006_HA1E_6H_X4_B4_DUO52HI53LO:K04|CPC006_HA1E_6H_X5_B4_DUO52HI53LO:K04                                                                                                                                                                                                                                                                                                                               \n",
       "18 REP.B007_HA1E_24H_X1_B24:M17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           \n",
       "19 REP.A007_HA1E_24H_X1_B22:M18|REP.A007_HA1E_24H_X2_B24:M18|REP.A007_HA1E_24H_X3_B22:M18                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "20 REP.B007_HA1E_24H_X1_B24:M15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           \n",
       "21 REP.A007_HA1E_24H_X1_B22:M17|REP.A007_HA1E_24H_X2_B24:M17|REP.A007_HA1E_24H_X3_B22:M17                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "22 REP.B007_HA1E_24H_X1_B24:M13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           \n",
       "23 REP.B007_HA1E_24H_X1_B24:M18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           \n",
       "24 REP.B007_HA1E_24H_X1_B24:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           \n",
       "25 REP.A007_HA1E_24H_X1_B22:M13|REP.A007_HA1E_24H_X2_B24:M13|REP.A007_HA1E_24H_X3_B22:M13                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "26 REP.A007_HA1E_24H_X1_B22:M16|REP.A007_HA1E_24H_X3_B22:M16                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "27 REP.A007_HA1E_24H_X1_B22:M15|REP.A007_HA1E_24H_X2_B24:M15|REP.A007_HA1E_24H_X3_B22:M15                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "28 REP.A007_HA1E_24H_X1_B22:M14|REP.A007_HA1E_24H_X2_B24:M14|REP.A007_HA1E_24H_X3_B22:M14                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "29 REP.B007_HA1E_24H_X1_B24:M14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           \n",
       "30 PCLB003_HA1E_24H_X1_B13:N20|PCLB003_HA1E_24H_X2_B13:N20|PCLB003_HA1E_24H_X3_B13:N20                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "31 PCLB003_HA1E_24H_X1_B13:N22|PCLB003_HA1E_24H_X2_B13:N22|PCLB003_HA1E_24H_X3_B13:N22                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "32 PCLB003_HA1E_24H_X1_B13:N21|PCLB003_HA1E_24H_X2_B13:N21|PCLB003_HA1E_24H_X3_B13:N21                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "33 PCLB003_HA1E_24H_X1_B13:N24|PCLB003_HA1E_24H_X2_B13:N24|PCLB003_HA1E_24H_X3_B13:N24                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "34 PCLB003_HA1E_24H_X1_B13:N19|PCLB003_HA1E_24H_X2_B13:N19|PCLB003_HA1E_24H_X3_B13:N19                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "35 PCLB003_HA1E_24H_X1_B13:N23|PCLB003_HA1E_24H_X2_B13:N23|PCLB003_HA1E_24H_X3_B13:N23                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "36 CPC006_HA1E_24H_X1.A2_F1B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X2_B3_DUO52HI53LO:N13|CPC006_HA1E_24H_X3_B3_DUO52HI53LO:N13                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "37 CPC007_HA1E_24H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_24H_X3_B3_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                      \n",
       "38 CPC007_HA1E_6H_X1_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X2_B3_DUO52HI53LO:H03|CPC007_HA1E_6H_X3_B3_DUO52HI53LO:H03                                                                                                                                                                                                                                                                                                                                                                                                         \n",
       "39 PBIOA014_HA1E_24H_X2_B21:L04|PBIOA014_HA1E_24H_X3_B21:L04                                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "40 PBIOA014_HA1E_24H_X1_B21:L05|PBIOA014_HA1E_24H_X2_B21:L05|PBIOA014_HA1E_24H_X3_B21:L05                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "41 PBIOA014_HA1E_24H_X1_B21:L02|PBIOA014_HA1E_24H_X2_B21:L02|PBIOA014_HA1E_24H_X3_B21:L02                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "42 PBIOA014_HA1E_24H_X1_B21:L03|PBIOA014_HA1E_24H_X2_B21:L03|PBIOA014_HA1E_24H_X3_B21:L03                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "43 PBIOA014_HA1E_24H_X1_B21:L01|PBIOA014_HA1E_24H_X2_B21:L01|PBIOA014_HA1E_24H_X3_B21:L01                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "44 PBIOA014_HA1E_24H_X1_B21:L06|PBIOA014_HA1E_24H_X2_B21:L06|PBIOA014_HA1E_24H_X3_B21:L06                                                                                                                                                                                                                                                                                                                                                                                                                                 \n",
       "45 CPC005_HA1E_6H_X3_B3_DUO52HI53LO:P15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   \n",
       "46 CPC005_HA1E_6H_X1_B3_DUO52HI53LO:D03|CPC005_HA1E_6H_X3_B3_DUO52HI53LO:D03                                                                                                                                                                                                                                                                                                                                                                                                                                              \n",
       "47 CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:H15|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:I13|CRCGN004_HA1E_6H_X6_F1B7_DUO52HI53LO:L18                                                                                                                                                                                                                                                                                                                                                                                             \n",
       "48 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:H15|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:I13                                                                                                                                                                                                                                                                                                                                                                                                                                    \n",
       "49 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07                                                                                                                              \n",
       "50 CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X6_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X7_F1B7_DUO52HI53LO:G07|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:D19|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:F18|CRCGN004_HA1E_24H_X8_F1B7_DUO52HI53LO:G07                                                                                                                              \n",
       "51 CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_6H_X3_F1B4_DUO52HI53LO:G07                                                                                                                                       \n",
       "52 CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X1_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:G07|CRCGN001_HA1E_24H_X2_F1B4_DUO52HI53LO:K11|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D14|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:D19|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:F18|CRCGN001_HA1E_24H_X3_F1B4_DUO52HI53LO:G07\n",
       "   build_name project_code cmap_name              is_ncs_exemplar\n",
       "1  NA         CPC          aminomethyltransferase 0              \n",
       "2  NA         CPC          aminomethyltransferase 1              \n",
       "3  NA         CPC          anagrelide             0              \n",
       "4  NA         CPC          anagrelide             0              \n",
       "5  NA         REP          anagrelide             1              \n",
       "6  NA         REP          anagrelide             0              \n",
       "7  NA         REP          anagrelide             0              \n",
       "8  NA         REP          anagrelide             0              \n",
       "9  NA         REP          anagrelide             0              \n",
       "10 NA         REP          anagrelide             0              \n",
       "11 NA         REP          anagrelide             0              \n",
       "12 NA         REP          anagrelide             0              \n",
       "13 NA         REP          anagrelide             0              \n",
       "14 NA         REP          anagrelide             0              \n",
       "15 NA         REP          anagrelide             0              \n",
       "16 NA         REP          anagrelide             0              \n",
       "17 NA         CPC          ARP-101                0              \n",
       "18 NA         REP          ARP-101                0              \n",
       "19 NA         REP          ARP-101                0              \n",
       "20 NA         REP          ARP-101                0              \n",
       "21 NA         REP          ARP-101                0              \n",
       "22 NA         REP          ARP-101                0              \n",
       "23 NA         REP          ARP-101                0              \n",
       "24 NA         REP          ARP-101                0              \n",
       "25 NA         REP          ARP-101                0              \n",
       "26 NA         REP          ARP-101                0              \n",
       "27 NA         REP          ARP-101                0              \n",
       "28 NA         REP          ARP-101                1              \n",
       "29 NA         REP          ARP-101                0              \n",
       "30 NA         PCLB         AVA                    0              \n",
       "31 NA         PCLB         AVA                    0              \n",
       "32 NA         PCLB         AVA                    0              \n",
       "33 NA         PCLB         AVA                    0              \n",
       "34 NA         PCLB         AVA                    1              \n",
       "35 NA         PCLB         AVA                    0              \n",
       "36 NA         CPC          BRD-K05402890          0              \n",
       "37 NA         CPC          BRD-K05402890          1              \n",
       "38 NA         CPC          BRD-K05402890          0              \n",
       "39 NA         PBIOA        BRD-K05402890          0              \n",
       "40 NA         PBIOA        BRD-K05402890          0              \n",
       "41 NA         PBIOA        BRD-K05402890          0              \n",
       "42 NA         PBIOA        BRD-K05402890          0              \n",
       "43 NA         PBIOA        BRD-K05402890          0              \n",
       "44 NA         PBIOA        BRD-K05402890          0              \n",
       "45 NA         CPC          R-59022                0              \n",
       "46 NA         CPC          ST-638                 0              \n",
       "47 NA         CRCGN        tributyltin            0              \n",
       "48 NA         CRCGN        tributyltin            1              \n",
       "49 NA         CRCGN        triphenyl-tin          0              \n",
       "50 NA         CRCGN        triphenyl-tin          0              \n",
       "51 NA         CRCGN        triphenyl-tin          0              \n",
       "52 NA         CRCGN        triphenyl-tin          0              "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "####extract drug information\n",
    "drug.RCC <- as.character(RCC.drug.result$Drug)\n",
    "drug.RCC <- sapply(drug.RCC, function(x){\n",
    "    a <- unlist(strsplit(x, \"__\"))\n",
    "    return(a[1:2])\n",
    "})\n",
    "drug.RCC <- unique(t(drug.RCC))\n",
    "\n",
    "idx <- apply(drug.RCC, 1, function(x){\n",
    "    index <- which(siginfo_beta$cmap_name == x[1] & siginfo_beta$cell_iname == x[2])\n",
    "    return(siginfo_beta[index, ])\n",
    "})\n",
    "drug..RCC.info <- ldply (idx, data.frame)\n",
    "write_xlsx(drug..RCC.info, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.drug.info.xlsx\")\n",
    "drug..RCC.info"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 41,
   "id": "c9077678-241d-4402-ab30-77ac9c4bd3cc",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:23:26.908720Z",
     "iopub.status.busy": "2021-09-23T06:23:26.905235Z",
     "iopub.status.idle": "2021-09-23T06:23:26.950160Z",
     "shell.execute_reply": "2021-09-23T06:23:26.948785Z"
    },
    "scrolled": true,
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 11 × 2</caption>\n",
       "<thead>\n",
       "\t<tr><th></th><th scope=col>Drug</th><th scope=col>mean.Zscore</th></tr>\n",
       "\t<tr><th></th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><th scope=row>triphenyl-tin__HA1E__trt_cp</th><td>triphenyl-tin__HA1E__trt_cp         </td><td>-2.005953</td></tr>\n",
       "\t<tr><th scope=row>AVA__HA1E__trt_cp</th><td>AVA__HA1E__trt_cp                   </td><td>-2.028199</td></tr>\n",
       "\t<tr><th scope=row>ST-638__HA1E__trt_cp</th><td>ST-638__HA1E__trt_cp                </td><td>-2.139165</td></tr>\n",
       "\t<tr><th scope=row>BRD-A51929314__HA1E__trt_cp</th><td>BRD-A51929314__HA1E__trt_cp         </td><td>-2.227154</td></tr>\n",
       "\t<tr><th scope=row>BRD-K05402890__HA1E__trt_cp</th><td>BRD-K05402890__HA1E__trt_cp         </td><td>-2.309873</td></tr>\n",
       "\t<tr><th scope=row>aminomethyltransferase__HA1E__trt_cp</th><td>aminomethyltransferase__HA1E__trt_cp</td><td>-2.349426</td></tr>\n",
       "\t<tr><th scope=row>ARP-101__HA1E__trt_cp</th><td>ARP-101__HA1E__trt_cp               </td><td>-2.420850</td></tr>\n",
       "\t<tr><th scope=row>R-59022__HA1E__trt_cp</th><td>R-59022__HA1E__trt_cp               </td><td>-2.440392</td></tr>\n",
       "\t<tr><th scope=row>homoharringtonine__HA1E__trt_cp</th><td>homoharringtonine__HA1E__trt_cp     </td><td>-2.545411</td></tr>\n",
       "\t<tr><th scope=row>anagrelide__HA1E__trt_cp</th><td>anagrelide__HA1E__trt_cp            </td><td>-2.888882</td></tr>\n",
       "\t<tr><th scope=row>tributyltin__HA1E__trt_cp</th><td>tributyltin__HA1E__trt_cp           </td><td>-3.094550</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 11 × 2\n",
       "\\begin{tabular}{r|ll}\n",
       "  & Drug & mean.Zscore\\\\\n",
       "  & <chr> & <dbl>\\\\\n",
       "\\hline\n",
       "\ttriphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp & triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & -2.005953\\\\\n",
       "\tAVA\\_\\_HA1E\\_\\_trt\\_cp & AVA\\_\\_HA1E\\_\\_trt\\_cp                    & -2.028199\\\\\n",
       "\tST-638\\_\\_HA1E\\_\\_trt\\_cp & ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & -2.139165\\\\\n",
       "\tBRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp & BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp          & -2.227154\\\\\n",
       "\tBRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp & BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & -2.309873\\\\\n",
       "\taminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & -2.349426\\\\\n",
       "\tARP-101\\_\\_HA1E\\_\\_trt\\_cp & ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & -2.420850\\\\\n",
       "\tR-59022\\_\\_HA1E\\_\\_trt\\_cp & R-59022\\_\\_HA1E\\_\\_trt\\_cp                & -2.440392\\\\\n",
       "\thomoharringtonine\\_\\_HA1E\\_\\_trt\\_cp & homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp      & -2.545411\\\\\n",
       "\tanagrelide\\_\\_HA1E\\_\\_trt\\_cp & anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & -2.888882\\\\\n",
       "\ttributyltin\\_\\_HA1E\\_\\_trt\\_cp & tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & -3.094550\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 11 × 2\n",
       "\n",
       "| <!--/--> | Drug &lt;chr&gt; | mean.Zscore &lt;dbl&gt; |\n",
       "|---|---|---|\n",
       "| triphenyl-tin__HA1E__trt_cp | triphenyl-tin__HA1E__trt_cp          | -2.005953 |\n",
       "| AVA__HA1E__trt_cp | AVA__HA1E__trt_cp                    | -2.028199 |\n",
       "| ST-638__HA1E__trt_cp | ST-638__HA1E__trt_cp                 | -2.139165 |\n",
       "| BRD-A51929314__HA1E__trt_cp | BRD-A51929314__HA1E__trt_cp          | -2.227154 |\n",
       "| BRD-K05402890__HA1E__trt_cp | BRD-K05402890__HA1E__trt_cp          | -2.309873 |\n",
       "| aminomethyltransferase__HA1E__trt_cp | aminomethyltransferase__HA1E__trt_cp | -2.349426 |\n",
       "| ARP-101__HA1E__trt_cp | ARP-101__HA1E__trt_cp                | -2.420850 |\n",
       "| R-59022__HA1E__trt_cp | R-59022__HA1E__trt_cp                | -2.440392 |\n",
       "| homoharringtonine__HA1E__trt_cp | homoharringtonine__HA1E__trt_cp      | -2.545411 |\n",
       "| anagrelide__HA1E__trt_cp | anagrelide__HA1E__trt_cp             | -2.888882 |\n",
       "| tributyltin__HA1E__trt_cp | tributyltin__HA1E__trt_cp            | -3.094550 |\n",
       "\n"
      ],
      "text/plain": [
       "                                     Drug                                \n",
       "triphenyl-tin__HA1E__trt_cp          triphenyl-tin__HA1E__trt_cp         \n",
       "AVA__HA1E__trt_cp                    AVA__HA1E__trt_cp                   \n",
       "ST-638__HA1E__trt_cp                 ST-638__HA1E__trt_cp                \n",
       "BRD-A51929314__HA1E__trt_cp          BRD-A51929314__HA1E__trt_cp         \n",
       "BRD-K05402890__HA1E__trt_cp          BRD-K05402890__HA1E__trt_cp         \n",
       "aminomethyltransferase__HA1E__trt_cp aminomethyltransferase__HA1E__trt_cp\n",
       "ARP-101__HA1E__trt_cp                ARP-101__HA1E__trt_cp               \n",
       "R-59022__HA1E__trt_cp                R-59022__HA1E__trt_cp               \n",
       "homoharringtonine__HA1E__trt_cp      homoharringtonine__HA1E__trt_cp     \n",
       "anagrelide__HA1E__trt_cp             anagrelide__HA1E__trt_cp            \n",
       "tributyltin__HA1E__trt_cp            tributyltin__HA1E__trt_cp           \n",
       "                                     mean.Zscore\n",
       "triphenyl-tin__HA1E__trt_cp          -2.005953  \n",
       "AVA__HA1E__trt_cp                    -2.028199  \n",
       "ST-638__HA1E__trt_cp                 -2.139165  \n",
       "BRD-A51929314__HA1E__trt_cp          -2.227154  \n",
       "BRD-K05402890__HA1E__trt_cp          -2.309873  \n",
       "aminomethyltransferase__HA1E__trt_cp -2.349426  \n",
       "ARP-101__HA1E__trt_cp                -2.420850  \n",
       "R-59022__HA1E__trt_cp                -2.440392  \n",
       "homoharringtonine__HA1E__trt_cp      -2.545411  \n",
       "anagrelide__HA1E__trt_cp             -2.888882  \n",
       "tributyltin__HA1E__trt_cp            -3.094550  "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "####identify the candidate drugs with Z-score\n",
    "mean.drug <- tapply(RCC.drug.result$ZSCORE, as.character(RCC.drug.result$Drug), mean)\n",
    "mean.drug <- data.frame(Drug = names(mean.drug), mean.Zscore = mean.drug)\n",
    "mean.drug <- mean.drug[order(mean.drug$mean.Zscore, decreasing = T),]\n",
    "mean.drug\n",
    "\n",
    "rankMean <- RCC.drug.result\n",
    "rankMean$Drug <- factor(rankMean $Drug, levels = mean.drug$Drug)\n",
    "rankMean <- arrange(rankMean, Drug)\n",
    "write_xlsx(rankMean, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.drug.meanRank.xlsx\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 42,
   "id": "f972ca60-a183-4218-af20-0ce0be77891c",
   "metadata": {
    "execution": {
     "iopub.execute_input": "2021-09-23T06:23:30.857272Z",
     "iopub.status.busy": "2021-09-23T06:23:30.822297Z",
     "iopub.status.idle": "2021-09-23T06:23:30.904004Z",
     "shell.execute_reply": "2021-09-23T06:23:30.902795Z"
    },
    "tags": [],
    "vscode": {
     "languageId": "r"
    }
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 11 × 5</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>Drug</th><th scope=col>TF</th><th scope=col>ZSCORE</th><th scope=col>Drug.name</th><th scope=col>cellLine</th></tr>\n",
       "\t<tr><th scope=col>&lt;fct&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;fct&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td>aminomethyltransferase__HA1E__trt_cp</td><td>HOXC5</td><td>-2.349426</td><td>aminomethyltransferase</td><td>HA1E</td></tr>\n",
       "\t<tr><td>anagrelide__HA1E__trt_cp            </td><td>ISL1 </td><td>-2.888882</td><td>anagrelide            </td><td>HA1E</td></tr>\n",
       "\t<tr><td>ARP-101__HA1E__trt_cp               </td><td>HOXC5</td><td>-2.420850</td><td>ARP-101               </td><td>HA1E</td></tr>\n",
       "\t<tr><td>AVA__HA1E__trt_cp                   </td><td>VENTX</td><td>-2.028199</td><td>AVA                   </td><td>HA1E</td></tr>\n",
       "\t<tr><td>BRD-A51929314__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.227154</td><td>BRD-A51929314         </td><td>HA1E</td></tr>\n",
       "\t<tr><td>BRD-K05402890__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.309873</td><td>BRD-K05402890         </td><td>HA1E</td></tr>\n",
       "\t<tr><td>homoharringtonine__HA1E__trt_cp     </td><td>HOXC5</td><td>-2.545411</td><td>homoharringtonine     </td><td>HA1E</td></tr>\n",
       "\t<tr><td>R-59022__HA1E__trt_cp               </td><td>HOXC5</td><td>-2.440392</td><td>R-59022               </td><td>HA1E</td></tr>\n",
       "\t<tr><td>ST-638__HA1E__trt_cp                </td><td>ISL1 </td><td>-2.139165</td><td>ST-638                </td><td>HA1E</td></tr>\n",
       "\t<tr><td>tributyltin__HA1E__trt_cp           </td><td>ISL1 </td><td>-3.094550</td><td>tributyltin           </td><td>HA1E</td></tr>\n",
       "\t<tr><td>triphenyl-tin__HA1E__trt_cp         </td><td>ISL1 </td><td>-2.005953</td><td>triphenyl-tin         </td><td>HA1E</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 11 × 5\n",
       "\\begin{tabular}{lllll}\n",
       " Drug & TF & ZSCORE & Drug.name & cellLine\\\\\n",
       " <fct> & <chr> & <dbl> & <fct> & <chr>\\\\\n",
       "\\hline\n",
       "\t aminomethyltransferase\\_\\_HA1E\\_\\_trt\\_cp & HOXC5 & -2.349426 & aminomethyltransferase & HA1E\\\\\n",
       "\t anagrelide\\_\\_HA1E\\_\\_trt\\_cp             & ISL1  & -2.888882 & anagrelide             & HA1E\\\\\n",
       "\t ARP-101\\_\\_HA1E\\_\\_trt\\_cp                & HOXC5 & -2.420850 & ARP-101                & HA1E\\\\\n",
       "\t AVA\\_\\_HA1E\\_\\_trt\\_cp                    & VENTX & -2.028199 & AVA                    & HA1E\\\\\n",
       "\t BRD-A51929314\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.227154 & BRD-A51929314          & HA1E\\\\\n",
       "\t BRD-K05402890\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.309873 & BRD-K05402890          & HA1E\\\\\n",
       "\t homoharringtonine\\_\\_HA1E\\_\\_trt\\_cp      & HOXC5 & -2.545411 & homoharringtonine      & HA1E\\\\\n",
       "\t R-59022\\_\\_HA1E\\_\\_trt\\_cp                & HOXC5 & -2.440392 & R-59022                & HA1E\\\\\n",
       "\t ST-638\\_\\_HA1E\\_\\_trt\\_cp                 & ISL1  & -2.139165 & ST-638                 & HA1E\\\\\n",
       "\t tributyltin\\_\\_HA1E\\_\\_trt\\_cp            & ISL1  & -3.094550 & tributyltin            & HA1E\\\\\n",
       "\t triphenyl-tin\\_\\_HA1E\\_\\_trt\\_cp          & ISL1  & -2.005953 & triphenyl-tin          & HA1E\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 11 × 5\n",
       "\n",
       "| Drug &lt;fct&gt; | TF &lt;chr&gt; | ZSCORE &lt;dbl&gt; | Drug.name &lt;fct&gt; | cellLine &lt;chr&gt; |\n",
       "|---|---|---|---|---|\n",
       "| aminomethyltransferase__HA1E__trt_cp | HOXC5 | -2.349426 | aminomethyltransferase | HA1E |\n",
       "| anagrelide__HA1E__trt_cp             | ISL1  | -2.888882 | anagrelide             | HA1E |\n",
       "| ARP-101__HA1E__trt_cp                | HOXC5 | -2.420850 | ARP-101                | HA1E |\n",
       "| AVA__HA1E__trt_cp                    | VENTX | -2.028199 | AVA                    | HA1E |\n",
       "| BRD-A51929314__HA1E__trt_cp          | ISL1  | -2.227154 | BRD-A51929314          | HA1E |\n",
       "| BRD-K05402890__HA1E__trt_cp          | ISL1  | -2.309873 | BRD-K05402890          | HA1E |\n",
       "| homoharringtonine__HA1E__trt_cp      | HOXC5 | -2.545411 | homoharringtonine      | HA1E |\n",
       "| R-59022__HA1E__trt_cp                | HOXC5 | -2.440392 | R-59022                | HA1E |\n",
       "| ST-638__HA1E__trt_cp                 | ISL1  | -2.139165 | ST-638                 | HA1E |\n",
       "| tributyltin__HA1E__trt_cp            | ISL1  | -3.094550 | tributyltin            | HA1E |\n",
       "| triphenyl-tin__HA1E__trt_cp          | ISL1  | -2.005953 | triphenyl-tin          | HA1E |\n",
       "\n"
      ],
      "text/plain": [
       "   Drug                                 TF    ZSCORE    Drug.name             \n",
       "1  aminomethyltransferase__HA1E__trt_cp HOXC5 -2.349426 aminomethyltransferase\n",
       "2  anagrelide__HA1E__trt_cp             ISL1  -2.888882 anagrelide            \n",
       "3  ARP-101__HA1E__trt_cp                HOXC5 -2.420850 ARP-101               \n",
       "4  AVA__HA1E__trt_cp                    VENTX -2.028199 AVA                   \n",
       "5  BRD-A51929314__HA1E__trt_cp          ISL1  -2.227154 BRD-A51929314         \n",
       "6  BRD-K05402890__HA1E__trt_cp          ISL1  -2.309873 BRD-K05402890         \n",
       "7  homoharringtonine__HA1E__trt_cp      HOXC5 -2.545411 homoharringtonine     \n",
       "8  R-59022__HA1E__trt_cp                HOXC5 -2.440392 R-59022               \n",
       "9  ST-638__HA1E__trt_cp                 ISL1  -2.139165 ST-638                \n",
       "10 tributyltin__HA1E__trt_cp            ISL1  -3.094550 tributyltin           \n",
       "11 triphenyl-tin__HA1E__trt_cp          ISL1  -2.005953 triphenyl-tin         \n",
       "   cellLine\n",
       "1  HA1E    \n",
       "2  HA1E    \n",
       "3  HA1E    \n",
       "4  HA1E    \n",
       "5  HA1E    \n",
       "6  HA1E    \n",
       "7  HA1E    \n",
       "8  HA1E    \n",
       "9  HA1E    \n",
       "10 HA1E    \n",
       "11 HA1E    "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "#### drug down-regulated the gene expression\n",
    "negative.zscore <- RCC.drug.result[which(RCC.drug.result$ZSCORE<0),]\n",
    "negative.zscore.mean <- tapply(negative.zscore$ZSCORE, as.character(negative.zscore$Drug), mean)\n",
    "negative.zscore.mean <- data.frame(Drug = names(negative.zscore.mean), mean.Zscore = negative.zscore.mean)\n",
    "negative.zscore.mean <- negative.zscore.mean[order(negative.zscore.mean$mean.Zscore),]\n",
    "#negative.zscore.mean\n",
    "\n",
    "negative.rankMean <- negative.zscore\n",
    "negative.rankMean$Drug.name <- gsub(\"__.*\", \"\", negative.rankMean$Drug)\n",
    "idx <- names(sort(table(negative.rankMean$Drug.name), decreasing = T))\n",
    "negative.rankMean$Drug.name <- factor(negative.rankMean$Drug.name, levels = idx)\n",
    "negative.rankMean <- arrange(negative.rankMean, Drug.name)\n",
    "write_xlsx(negative.rankMean, \"/data/active_data/lzl/RenalTumor-20200713/DataAnalysis-20210803/Drug/LINCS/lincs.TF.RCC.drug.negative.rankMean.xlsx\")\n",
    "negative.rankMean"
   ]
  }
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