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Kathleen Warren
KathleenW/
Ischemic-Stroke-miRna
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Series GSE272079 Query DataSets for GSE272079
Status Public on Oct 25, 2024
Title miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, and immune regulation, and monitor disease development. We established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM). Clean data (15.48 Gb) were obtained for lncRNAs and mRNAs. Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified. Finally, gene expression profiles and differentially expressed genes were analysed in 20 samples. In the plasma samples, 74 miRNAs, 12 lncRNAs, and 693 mRNAs were identified. Tumour-derived tissue samples contained 61 miRNAs, 67 lncRNAs, and 433 mRNAs. This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS versus CM without stroke.
 
Overall design We established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).
 
Contributor(s) Ma L, Liu G
Citation(s)
  • Ma L, Liu YH, Liu C, Wang SQ et al. lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke. Sci Data 2025 Jan 16;12(1):91. PMID: 39820519
BioProject
  • PRJNA1111286 miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke
Submission date Jul 11, 2024
Last update date Feb 14, 2025
Contact name Lin Ma
E-mail(s) linma0720@aliyun.com
Organization name Beijing Anzhen Hospital
Street address No. 2 Anzhen Rd District, Beijing, China
City Beijing
ZIP/Postal code 100029
Country China
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (20)
GSM8392622 A1, mi, non-IS
GSM8392623 A3, mi, non-IS
GSM8392624 A4, mi, non-IS
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Supplementary file Size Download File type/resource
GSE272079_All_miRNA_UMI.TPM.list.txt.gz 44.2 Kb (ftp)(http) TXT
GSE272079_differential_analysis_table_of_miRNA_in_plasma_exosomes.DEG_final.txt.gz 4.2 Kb (ftp)(http) TXT
GSE272079_differential_analysis_table_of_miRNA_in_tumor_exosomes.DEG_final.txt.gz 3.8 Kb (ftp)(http) TXT
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