|
| Status |
Public on Oct 25, 2024 |
| Title |
miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, and immune regulation, and monitor disease development. We established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM). Clean data (15.48 Gb) were obtained for lncRNAs and mRNAs. Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified. Finally, gene expression profiles and differentially expressed genes were analysed in 20 samples. In the plasma samples, 74 miRNAs, 12 lncRNAs, and 693 mRNAs were identified. Tumour-derived tissue samples contained 61 miRNAs, 67 lncRNAs, and 433 mRNAs. This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS versus CM without stroke.
|
| |
|
| Overall design |
We established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM).
|
| |
|
| Contributor(s) |
Ma L, Liu G |
| Citation(s) |
- Ma L, Liu YH, Liu C, Wang SQ et al. lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke. Sci Data 2025 Jan 16;12(1):91. PMID: 39820519
|
| BioProject |
- PRJNA1111286 miRNA profiles of plasma and tumor-derived exosomes of cardiac myxoma-related ischemic stroke
|
| |
| Submission date |
Jul 11, 2024 |
| Last update date |
Feb 14, 2025 |
| Contact name |
Lin Ma |
| E-mail(s) |
linma0720@aliyun.com
|
| Organization name |
Beijing Anzhen Hospital
|
| Street address |
No. 2 Anzhen Rd District, Beijing, China
|
| City |
Beijing |
| ZIP/Postal code |
100029 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
|
