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Haley Delamora
Haley-Delamora/
GDS-in-Cancer
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# DRUG_ID SCREENING_SITE DRUG_NAME SYNONYMS TARGET TARGET_PATHWAY
1 1 MGH Erlotinib Tarceva, RG-1415, CP-358774, OSI-774, Ro-508231, R-1415 EGFR EGFR signaling
2 3 MGH Rapamycin AY-22989, Sirolimus, WY-090217, Torisel, Rapamune MTORC1 PI3K/MTOR signaling
3 5 MGH Sunitinib Sutent, Sunitinib Malate, SU-11248 PDGFR, KIT, VEGFR, FLT3, RET, CSF1R RTK signaling
4 6 MGH PHA-665752 PHA665752, PHA 665752 MET RTK signaling
5 9 MGH MG-132 LLL cpd, MG 132, MG132 Proteasome, CAPN1 Protein stability and degradation
6 11 MGH Paclitaxel BMS-181339-01, Taxol, Onxol, Paxene, Praxel, Abraxane Microtubule stabiliser Mitosis
7 17 MGH Cyclopamine SMO Other
8 29 MGH AZ628 AZ-628, AZ 628 BRAF ERK MAPK signaling
9 30 MGH Sorafenib Nexavar, 284461-73-0, BAY 43-9006 PDGFR, KIT, VEGFR, RAF RTK signaling
10 32 MGH Tozasertib MK 0457,MK-0457,MK-045, VX-680 VX 680 VX-68 AURKA, AURKB, AURKC, others Mitosis
11 34 MGH Imatinib Gleevec, STI-571 ABL, KIT, PDGFR Other, kinases
12 35 MGH NVP-TAE684 NVP-TAE 684, TAE684, TAE-684 ALK RTK signaling
13 37 MGH Crizotinib Xalkori, PF2341066, PF-2341066, PF 2341066 MET, ALK, ROS1 RTK signaling
14 38 MGH Saracatinib AZD0530, AZD-0530, AZ-10353926 ABL, SRC Other, kinases
15 41 MGH S-Trityl-L-cysteine NSC 83265, Tritylcysteine KIF11 Mitosis
16 45 MGH Z-LLNle-CHO Z-L-Norleucine-CHO, Gamma-Secretase Inhibitor 1 gamma-secretase Other
17 51 MGH Dasatinib BMS-354825-03, BMS-354825, Sprycel ABL, SRC, Ephrins, PDGFR, KIT RTK signaling
18 52 MGH GNF-2 KIN001-013 BCR-ABL ABL signaling
19 53 MGH CGP-60474 KIN001-019, CGP60474, CGP 60474 CDK1,CDK2,CDK5,CDK7,CDK9, PKC Cell cycle
20 54 MGH CGP-082996 CINK4, KIN001-021 CDK4 Cell cycle
21 55 MGH A-770041 KIN001-111 LCK, FYN Other, kinases
22 56 MGH WH-4-023 KIN001-112 SRC, LCK Other, kinases
23 59 MGH WZ-1-84 KIN001-123 BMX Other, kinases
24 60 MGH BI-2536 PLK1, PLK2, PLK3 Cell cycle
25 62 MGH BMS-536924 BMS 536924 IGF1R, IR IGF1R signaling
26 63 MGH BMS-509744 KIN001-127, ITK inhibitor ITK Other, kinases
27 64 MGH CMK KIN001-128 RSK2 Other, kinases
28 71 MGH Pyrimethamine Daraprim, Chloridine Dihydrofolate reductase (DHFR) Other
29 83 MGH JW-7-52-1 NA MTOR PI3K/MTOR signaling
30 86 MGH A-443654 KIN001-139 AKT1, AKT2, AKT3 PI3K/MTOR signaling
31 87 MGH GW843682X GW843682X (AN-13) PLK1 Cell cycle
32 88 MGH Entinostat MS-275 HDAC1, HDAC3 Chromatin histone acetylation
33 89 MGH Parthenolide HDAC1 Chromatin histone acetylation
34 91 MGH GSK319347A KIN001-135, IKK-3 inhibitor IKK Other, kinases
35 94 MGH TGX221 TGX-221, Tgx 221 PI3Kbeta PI3K/MTOR signaling
36 104 MGH Bortezomib PS-341, LDP-341, Velcade Proteasome Protein stability and degradation
37 106 MGH XMD8-85 ERK5-IN-1 ERK5, BET Other
38 110 MGH Seliciclib Roscovitine, CYC-202, AL-39256 CDK2, CDK7, CDK9 Cell cycle
39 111 MGH Salubrinal EIF-2alpha Inhibitor EIF2A Other
40 119 MGH Lapatinib Tykerb, Tyverb EGFR, ERBB2 RTK signaling
41 127 MGH GSK269962A GSK 269962A ROCK1, ROCK2 Cytoskeleton
42 133 MGH Doxorubicin Doxil, Rubex, Adriamycin, Adriablastin, Doxorubicine Anthracycline DNA replication
43 134 MGH Etoposide Etopophos, Vepesid, Eposin, VP-16 TOP2 DNA replication
44 135 MGH Gemcitabine Gemzar, LY-188011 Pyrimidine antimetabolite DNA replication
45 136 MGH Mitomycin-C Mytozytrex, NSC-26980, MMC, Mitosol, Mitozytrex DNA crosslinker DNA replication
46 140 MGH Vinorelbine vinorelbine tartrate, Navelbine, Exelbine Microtubule destabiliser Mitosis
47 147 MGH NSC-87877 NSC 87877 SHP-1 (PTPN6), SHP-2 (PTPN11) Other
48 150 MGH Bicalutamide ICI-176334, Casodex, Cosudex, ICI 176334 AR Hormone-related
49 151 MGH QS11 944328-88-5 ARFGAP1 Other
50 152 MGH CP466722 CP-466722, CP 466722, 1080622-86-1 ATM Genome integrity
51 153 MGH Midostaurin PKC412, benzoylstaurosporine, CGP-41251 PKC, PPK, FLT1, c-FGR, others Other
52 154 MGH CHIR-99021 CT 99021, CHIR99021, CHIR 99021 GSK3A, GSK3B WNT signaling
53 155 MGH Ponatinib AP24534, AP-24534, KIN001-192, Iclusig ABL, PDGFRA, VEGFR2, FGFR1, SRC, TIE2, FLT3 Other, kinases
54 156 MGH AZD6482 AZD 6482, AZD-6482, AK-55409 PI3Kbeta PI3K/MTOR signaling
55 157 MGH JNK-9L KIN001-204, JNK inhibitor 9l JNK2, JNK3 JNK and p38 signaling
56 158 MGH PF-562271 PF-00562271 FAK, FAK2 Cytoskeleton
57 159 MGH HG6-64-1 KIN001-206 BRAF ERK MAPK signaling
58 163 MGH JQ1 JQ-1, (+)-JQ-1 BRD2, BRD3, BRD4, BRDT Chromatin other
59 164 MGH JQ12 HDAC1, HDAC2 Chromatin histone acetylation
60 165 MGH DMOG Dimethyloxalylglcine HIF-PH Metabolism
61 166 MGH FTI-277 Farnesyl-transferase (FNTA) Other
62 167 MGH OSU-03012 AR-12, OSU 03012, OSU03012, PDK1 inhibitor AR-12 PDK1 (PDPK1) Metabolism
63 170 MGH Shikonin Anchusin not defined Other
64 171 MGH AKT inhibitor VIII Akti-1/2, KIN001-102 AKT1, AKT2, AKT3 PI3K/MTOR signaling
65 172 MGH Embelin Emberine, Embelic acid XIAP Apoptosis regulation
66 173 MGH FH535 PPARgamma, PPARdelta Other
67 175 MGH PAC-1 GTPL5238 Procaspase-3, Procaspase-7 Apoptosis regulation
68 176 MGH IPA-3 IPA 3 PAK1 Cytoskeleton
69 177 MGH GSK650394 GSK-650394, GSK 650394 SGK2, SGK3 Other, kinases
70 178 MGH BAY-61-3606 Syk Inhibitor, BAY-613606 SYK Other, kinases
71 179 MGH 5-Fluorouracil 5-FU Antimetabolite (DNA & RNA) Other
72 180 MGH Thapsigargin Octanoic acid SERCA Other
73 182 MGH Obatoclax Mesylate GX15-070MS, Obatoclax, GX15-070 BCL2, BCL-XL, BCL-W, MCL1 Apoptosis regulation
74 184 MGH BMS-754807 BMS754807, BMS 754807 IGF1R, IR RTK signaling
75 185 MGH Linsitinib OSI-906, ASP-7487 IGF1R IGF1R signaling
76 186 MGH Bexarotene LG-100069, Targretin, Targret, Targrexin, Targretyn, Bexarotenum Retinioic X receptor (RXR) agonist Other
77 190 MGH Bleomycin dsDNA break induction DNA replication
78 192 MGH LFM-A13 DDE-28 BTK Other, kinases
79 193 MGH GW-2580 GX2580, CFMS receptor tyrosine kinase inhibitor CSF1R RTK signaling
80 194 MGH Luminespib AUY922, VER-52296,NVP-AUY922, AUY HSP90 Protein stability and degradation
81 196 MGH Phenformin DBI Biguanide agent Other
82 197 MGH Bryostatin 1 Bryostatin PKC Other
83 199 MGH Pazopanib Votrient CSF1R, KIT, PDGFRA, PDGFRB RTK signaling
84 200 MGH Dacinostat NVP-LAQ824, LAQ824 HDAC1 Chromatin histone acetylation
85 201 MGH Epothilone B Patupilone, EpoB, EPO906, GNF-PF-193 Microtubule stabiliser Mitosis
86 202 MGH GSK1904529A GSK-1904529A, GSK 1904529A IGF1R, IR RTK signaling
87 203 MGH BMS-345541 BMS345541, IKK Inhibitor 3 IKK1, IKK2 Other, kinases
88 204 MGH Tipifarnib Zarnestra Farnesyl-transferase (FNTA) Other
89 205 MGH Avagacestat BMS-708163, BMS 708163 Amyloid beta20, Amyloid beta40 Other
90 206 MGH Ruxolitinib INCB-18424, Ruxolitinib Phosphate, Jakafi JAK1, JAK2 Other, kinases
91 207 MGH AS601245 JNK1, JNK2, JNK2 JNK and p38 signaling
92 208 MGH Ispinesib Mesylate SB-715992 KSP Mitosis
93 211 MGH TL-2-105 not defined Other
94 219 MGH AT-7519 AT7519 CDK1, CDK2, CDK4, CDK6, CDK9 Cell cycle
95 221 MGH TAK-715 KIN001-201, TAK 715 p38alpha, p38beta JNK and p38 signaling
96 222 MGH BX-912 PDK1 (PDPK1) Metabolism
97 223 MGH ZSTK474 KIN001-167, ZSTK-474, ZSTK 474 PI3K (class 1) PI3K/MTOR signaling
98 224 MGH AS605240 KIN001-173, AS-605240 PI3Kgamma PI3K/MTOR signaling
99 225 MGH Genentech Cpd 10 AURKA, AURKB Mitosis
100 226 MGH GSK1070916 GSK-1070916 AURKA, AURKC Mitosis