--- a +++ b/README.md @@ -0,0 +1,75 @@ +<table><tbody><tr><td><table cellpadding="2" cellspacing="0" width="600"><tbody><tr bgcolor="#cccccc" valign="top"><td colspan="2"><table width="600"><tbody><tr><td><strong class="acc" id="GSE241405"><a href="/geo/query/acc.cgi?acc=GSE241405" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">Series GSE241405</a></strong></td> +<td></td> +<td align="right" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_gds)"><a href="/gds/?term=GSE241405[Accession]">Query DataSets for GSE241405</a></td> +</tr></tbody></table></td></tr> +<tr valign="top"><td>Status</td> +<td>Public on Mar 07, 2025</td> +</tr> +<tr valign="top"><td nowrap="">Title</td> +<td style="text-align: justify">Single cell transcriptomic landscape of pediatric B-cell acute lymphoblastic leukemia: dissection of transcriptional heterogeneity and B-cell developmental state</td> +</tr> +<tr valign="top"><td nowrap="">Organism</td> +<td><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=9606" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_organismus)">Homo sapiens</a></td> +</tr> +<tr valign="top"><td nowrap="">Experiment type</td> +<td>Expression profiling by high throughput sequencing<br></td> +</tr> +<tr valign="top"><td nowrap="">Summary</td> +<td style="text-align: justify">Genomic analyses of bulk ALL samples have improved our understanding of the genetic basis and risk stratification of B-cell acute lymphoblastic leukemia (B-ALL), but do not directly examine intratumor heterogeneity or enable inference of leukemia developmental state and cell of origin. In this study we profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) to investigate transcriptional heterogeneity and developmental states of leukemic cells.<br></td> +</tr> +<tr valign="top"><td nowrap=""> </td> +<td></td> +</tr> +<tr valign="top"><td nowrap="">Overall design</td> +<td style="text-align: justify">We profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) and compared them to a scRNA-seq reference map of normal human B-cell development.<br>**Submitter states that clinical description will be provided in the corresponding publication as supplemental tables, if relevant to the study's conclusion**<br>**Raw data were submitted to EGA under accession number EGAS00001007512**<br></td> +</tr> +<tr valign="top"><td nowrap=""> </td> +<td></td> +</tr> +<tr valign="top"><td>Contributor(s)</td> +<td><a href="/pubmed/?term=Iacobucci I[Author]">Iacobucci I</a>, <a href="/pubmed/?term=Mullighan C[Author]">Mullighan C</a></td> +</tr> +<tr valign="top"><td>Citation missing</td> +<td class="message" id="pmidCell">Has this study been published? Please <a href="/geo/submitter">login</a> to update or <a href="mailto:geo@ncbi.nlm.nih.gov?subject=Citation for GSE241405 [not logged in]&body=Thank you very much for helping to keep GEO citation links up-to-date. Please enter the PubMed ID (PMID) or full citation for GSE241405 below, and we will update the record accordingly within the next day or two. The PubMed ID or citation is: +">notify GEO</a>.</td> +</tr> +<tr valign="top"><td colspan="2"><span id="geo2r"></span> <span id="rnaseq_counts"></span></td></tr> +<tr bgcolor="#eeeeee" valign="top"><td>Submission date</td> +<td>Aug 22, 2023</td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td>Last update date</td> +<td>Mar 08, 2025</td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td>Contact name</td> +<td>QINGSONG GAO</td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">E-mail(s)</td> +<td><a href="mailto:gaoqs313@gmail.com">gaoqs313@gmail.com</a><br></td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Organization name</td> +<td style="text-align: justify">ST JUDE CHILDREN'S RESEARCH HOSPITAL<br></td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Street address</td> +<td style="text-align: justify">262 DANNY THOMAS PLACE<br></td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">City</td> +<td style="text-align: justify">MEMPHIS</td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">State/province</td> +<td style="text-align: justify">Tennessee</td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">ZIP/Postal code</td> +<td style="text-align: justify">38105</td> +</tr> +<tr bgcolor="#eeeeee" valign="top"><td nowrap="">Country</td> +<td style="text-align: justify">USA</td> +</tr> +<tr valign="top"><td nowrap=""> </td> +<td></td> +</tr> +<tr valign="top"><td>Platforms (1)</td> +<td onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)"><table cellpadding="3" style="position:relative;top:-5px;left:-5px"><tbody><tr><td valign="top"><a href="/geo/query/acc.cgi?acc=GPL24676" onmouseout="onLinkOut('HelpMessage' , geo_empty_help)" onmouseover="onLinkOver('HelpMessage' , geoaxema_recenter)">GPL24676</a></td> +<td valign="top">Illumina NovaSeq 6000 (Homo sapiens)</td> +</tr></tbody></table></td> +</tr> +</td></tr></tbody></table> \ No newline at end of file