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| Status |
Public on Mar 07, 2025 |
| Title |
Single cell transcriptomic landscape of pediatric B-cell acute lymphoblastic leukemia: dissection of transcriptional heterogeneity and B-cell developmental state |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Genomic analyses of bulk ALL samples have improved our understanding of the genetic basis and risk stratification of B-cell acute lymphoblastic leukemia (B-ALL), but do not directly examine intratumor heterogeneity or enable inference of leukemia developmental state and cell of origin. In this study we profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) to investigate transcriptional heterogeneity and developmental states of leukemic cells.
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| Overall design |
We profiled 89 B-ALL samples by single-cell RNA-seq (scRNA-seq) (10X Genomics 5’v2) and compared them to a scRNA-seq reference map of normal human B-cell development.
**Submitter states that clinical description will be provided in the corresponding publication as supplemental tables, if relevant to the study's conclusion**
**Raw data were submitted to EGA under accession number EGAS00001007512**
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| Contributor(s) |
Iacobucci I, Mullighan C |
| Citation missing |
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| Submission date |
Aug 22, 2023 |
| Last update date |
Mar 08, 2025 |
| Contact name |
QINGSONG GAO |
| E-mail(s) |
gaoqs313@gmail.com
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| Organization name |
ST JUDE CHILDREN'S RESEARCH HOSPITAL
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| Street address |
262 DANNY THOMAS PLACE
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| City |
MEMPHIS |
| State/province |
Tennessee |
| ZIP/Postal code |
38105 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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