# MI inverse inference

Code for the inverse inference of infarcted area from ECG and MRI for myocardial infarction (MI) patients. This is achieved within a cardiac digital twin (CDT) framework, where the anatomical twinning personalizes the geometrical model, while functional twinning personalizes the electrophysiological model.

![](fig/cardiac_digital_twins.png)

## Notes:<a id="Summary"/>

1. *Cardiac_Personalisation-SenAnalysis* fold only contain partial code for the ECG simulation and the sensitivity analysis. For the full Eikonal-based ECG simulation code, please contact [Dr Julia Camps](mailto:julia.camps@cs.ox.ac.uk).

2. *Cobiveco* fold only contrain partial code for converting biventicle mesh into cobiveco mesh. For the complete Cobiveco mesh reconstruction code, please visit [KIT-IBE Cobiveco Github repository](https://github.com/KIT-IBT/Cobiveco).

## Package dependencies:<a id="Package dependencies"/>

This repository is based on PyTorch, running on a computer with 3.50~GHz Intel(R) Xeon(R) E-2146G CPU and an NVIDIA GeForce RTX 3060.

## Dataset:<a id="Dataset"/>

Our network is trained based on UKB dataset, which contains paired multi-view MRIs and ECG data. We have reconstruced the cardiac geometry from the multi-view MRIs and converted it into cobiveco mesh. The scar/border zone area were assigned on the mesh and subsequently used for ECG simulation of MI patients.

The data folder should be like:

```

tree

`-- UKB_clinical_data

    `-- patientID

    |    |-- patientID_cobiveco_AHA17.vtu

    |    |-- patientID_heart_cobiveco.vtu

    |    |-- patientID_simulated_ECG_xxx_subendo.csv

    |    |-- patientID_simulated_ECG_xxx_transmural.csv

    |    |-- ...

    |    |-- patientID_electrodePosition.csv

```

## Citation:<a id="Citation"/>

If you find this code useful in your research, please consider citing:

```

@article{jounral/TMI/li2024,

  title={Towards Enabling Cardiac Digital Twins of Myocardial Infarction Using Deep Computational Models for Inverse Inference},

  author={Li, Lei and Camps, Julia and Wang, Zhinuo and Banerjee, Abhirup and Rodriguez, Blanca and Grau, Vicente},

  journal={IEEE Transactions on Medical Imaging},

  year={2024}

}

```