Get emergency medical help if you have signs of an allergic reaction to Sprycel: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor right away if you have any symptoms of pulmonary arterial hypertension (PAH), such as:
chest pain, feeling tired or short of breath (even with mild exertion);
swelling in your feet, lower legs, or midsection;
blue-colored lips and skin; and
a light-headed feeling, like you might pass out.
Also call your doctor at once if you have:
severe ongoing nausea, vomiting, or diarrhea;
severe headaches, extreme tiredness, muscle or joint pain;
pain when you breathe, shortness of breath (especially when lying down);
swelling, rapid weight gain;
chest pain, pounding heartbeats or fluttering in your chest;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
other signs of bleeding - blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, confusion, headache, problems with speech;
low blood cell counts - fever, chills, tiredness, flu-like symptoms, mouth sores, skin sores, pale skin, cold hands and feet, feeling light-headed; or
signs of tumor cell breakdown - muscle cramps, nausea, vomiting, weakness, swelling, feeling short of breath, or seizure.
Sprycel may affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common Sprycel side effects may include:
nausea, diarrhea, stomach pain;
headache, muscle pain, pain in your hands or feet;
breathing problems;
skin rash; or
feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Sprycel side effects (more detail)
