Get emergency medical help if you have signs of an allergic reaction to Premarin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, sweating;
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
signs of a blood clot - sudden vision loss, stabbing chest pain, coughing up blood, pain or warmth in one or both legs;
swelling, rapid weight gain;
jaundice (yellowing of the skin or eyes);
memory problems, confusion, unusual behavior;
unusual vaginal bleeding, pelvic pain;
a lump in your breast; or
high levels of calcium in your blood - vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.
Common Premarin side effects may include:
swelling;
hair loss;
numbness, tingling, burning pain;
back pain, leg cramps, pain;
bloating, gas, indigestion, nausea, vomiting, stomach pain;
dizziness, headache;
breast pain; or
vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Premarin side effects (more detail)
