Taking  Butalbital Compound with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
You should not use Butalbital Compound if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor about all your current medicines and any you start or stop using, especially:
mercaptopurine;
methotrexate;
probenecid;
insulin or oral diabetes medicine;
a blood thinner--warfarin, Coumadin, Jantoven; or
steroid medicine--prednisone, dexamethasone, and others.
This list is not complete. Other drugs may interact with aspirin, butalbital, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
 Butalbital Compound drug interactions (more detail)
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