Usual Adult Dose for Reversal of Acquired Coagulation Factor Deficiency:
INR 2 to less than 4: 25 units of Factor IX/kg body weight given intravenously
INR 4 to 6: 35 units of Factor IX/kg body weight given intravenously
INR greater than 6: 50 units of Factor IX/kg body weight given intravenously
Maximum dose:
INR 2 to less than 4: 2500 units of Factor IX
INR 4 to 6: 3500 units of Factor IX
INR greater than 6: 5000 units of Factor IX
Duration of therapy: Single dose. Repeat dosing is not supported by clinical data and is not recommended.
Comments:
-Administer Vitamin K concurrently to maintain Vitamin K dependent clotting factor levels once the effects of Kcentra concentrate have diminished.
-Individualize dosing based on the patient's current predose International Normalized Ratio (INR) value, and body weight.
-Dose is based on body weight up to but not exceeding 100 kg. Do not exceed stated maximum dose for patients weighing more than 100 kg.
-Dosing is based on actual potency. The potency varies from vial to vial and is stated on the carton. Potency varies from 20-31 Factor IX units/mL. Nominal potency is 500 units per vial or approximately 25 units per mL after reconstitution.
 Detailed Kcentra dosage information
What happens if I miss a dose?
Since Kcentra is used when needed, it is usually given as a single dose.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
