Get emergency medical help if you have signs of an allergic reaction to Eliquis: hives; chest pain, wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.
Also seek emergency medical attention if you have symptoms of a spinal blood clot: back pain, numbness or muscle weakness in your lower body, or loss of bladder or bowel control.
Call your doctor at once if you have:
bleeding (from any area including nose, mouth, vagina, or rectum) that will not stop;
headache, dizziness, weakness, feeling like you might pass out;
urine that looks red, pink, or brown; or
black or bloody stools, coughing up blood or vomit that looks like coffee grounds.
The most common side effects of Eliquis include easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), or bleeding from injection sites.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Eliquis side effects (more detail)
