Get emergency medical help if you have signs of an allergic reaction to Opdivo (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, short of breath, itchy, or tingly, or if you have a fever, chills, back pain or neck pain.
Call your doctor at once if you have:
severe or ongoing diarrhea, severe stomach pain, bloody or tarry stools;
eye pain, vision changes, sensitivity to light;
severe muscle pain or weakness;
confusion, memory problems, neck stiffness, drowsiness, balance problems;
numbness or tingling in your arms or legs;
kidney problems - little or no urination, swelling in your feet or ankles, blood in your urine;
liver problems - severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);
lung problems - new or worsening cough, chest pain, feeling short of breath;
skin problems - rash, itching, redness, swelling, pain, sores, blisters, sores in your mouth or nose or on your genitals;
signs of a hormonal disorder - frequent or unusual headaches, vision problems, fast heartbeats, dizziness, fainting, tiredness, mood or behavior changes, hunger, increased thirst or urination, constipation, hair loss, hoarse or deepened voice, sweating, feeling cold, weight gain or loss; or
(if you have had a stem cell transplant) feeling sick or uneasy, with pain or swelling near your transplanted organ.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Opdivo side effects may include:
nausea, vomiting, stomach pain, loss of appetite, diarrhea, constipation;
mouth sores, altered sense of taste;
itching, rash, redness or blisters on your hands or feet;
hormonal problems;
liver problems;
numbness, tingling, or burning pain in your hands or feet;
fever, body aches;
feeling weak, tired, or short of breath;
cold symptoms such as runny or stuffy nose, cough, sore throat;
headache, dizziness, increased blood pressure; or
weight loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Opdivo side effects (more detail)
