You should not use Juxtapid if you have severe liver disease or a history of abnormal liver function tests.
Do not use if you are pregnant. Birth control pills may be less effective if you vomit or have diarrhea. Ask your doctor about the best way to prevent pregnancy while you are taking Juxtapid.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with lomitapide, and some drugs should not be used together.
Lomitapide can cause liver problems. Call your doctor at once if you have nausea, vomiting, upper stomach pain, tiredness, flu-like symptoms, dark urine, or jaundice (yellowing of the skin or eyes).
Before taking this medicine
You should not use Juxtapid if you are allergic to lomitapide, or if:
you have severe liver disease;
you have abnormal liver function tests; or
you are pregnant.
Many drugs can interact and cause dangerous effects. Some drugs should not be used together with lomitapide. Your doctor may change your treatment plan if you also use:
aprepitant;
conivaptan;
crizotinib, imatinib;
nefazodone;
an antibiotic - ciprofloxacin, clarithromycin, erythromycin, telithromycin;
antifungal medication - fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;
heart or blood pressure medicine - diltiazem, verapamil;
hepatitis C medication - boceprevir or telaprevir; or
HIV or AIDS medicine - atazanavir, darunavir when given with ritonavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir.
To make sure Juxtapid is safe for you, tell your doctor if you have:
liver problems, even if caused by taking certain medicines;
kidney disease (or if you are on dialysis);
bowel problems, or an intestinal disorder;
hereditary galactose intolerance, severe lactase deficiency, or glucose galactose malabsorption; or
if you drink large amounts of alcohol.
You may need to have a negative pregnancy test before starting this treatment.
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Lomitapide could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine.
If you become pregnant, your name may be listed on a pregnancy registry to track the effects of lomitapide on the baby.
Birth control pills may be less effective if you vomit or have diarrhea. Ask your doctor about the best way to prevent pregnancy while taking Juxtapid.
You should not breastfeed while using lomitapide.
Juxtapid is not approved for use by anyone younger than 18 years old.
How should I take Juxtapid?
Juxtapid is usually taken once daily, at least 2 hours after your evening meal. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Your doctor will perform blood tests to make sure lomitapide is safe for you to take.
Take Juxtapid on an empty stomach, at least 2 hours after your evening meal.
Swallow the capsule whole and do not crush, chew, break, or dissolve it. Take this medicine with a full glass of water.
Your doctor may have you take vitamin E or essential fatty acid supplements while you are taking Juxtapid. Take only the type and amount of vitamins or supplements your doctor has prescribed.
You will need frequent medical tests.
Juxtapid is only part of a treatment program that may also include exercise and weight control. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
