Ask your doctor before using naproxen if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.
Ask a doctor or pharmacist if it is safe for you to use this medicine if you are also using any of the following drugs:
cholestyramine;
cyclosporine;
digoxin;
lithium;
methotrexate;
pemetrexed;
phenytoin or similar seizure medications;
probenecid;
warfarin (Coumadin, Jantoven) or similar blood thinners;
a diuretic or "water pill";
heart or blood pressure medication; or
insulin or oral diabetes medicine.
This list is not complete. Other drugs may interact with naproxen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
 Naproxen drug interactions (more detail)
