Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
new or unusual pain in your thigh or hip;
jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work;
severe joint, bone, or muscle pain;
kidney problems--little or no urination, swelling in your feet or ankles, feeling tired;
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).
Serious side effects on the kidneys may be more likely in older adults.
Common side effects may include:
trouble breathing;
nausea, vomiting, diarrhea, constipation;
bone pain, muscle or joint pain;
fever or other flu symptoms;
tiredness;
eye pain or swelling;
pain in your arms or legs;
headache; or
anemia.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Zoledronic acid side effects (more detail)
