Get emergency medical help if you have signs of an allergic reaction to Probuphine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Inserting or removing the Probuphine implant can cause serious or life-threatening complications, including damage to nerves or blood vessels. Ask your doctor about these risks.
Call your doctor at once if you have:
opioid withdrawal symptoms - shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, vomiting;
confusion, agitation, or other changes in your mental status;
extreme drowsiness, trouble concentrating;
a light-headed feeling, like you might pass out;
weak or shallow breathing, breathing that stops during sleep;
blurred vision, slurred speech, problems with walking, reflexes, or coordination; or
low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common Probuphine side effects may include:
pain, itching, redness, swelling, bruising, or bleeding where the implants were inserted;
headache, depressed mood;
nausea, vomiting, constipation;
back pain;
tooth pain; or
sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Probuphine side effects (more detail)
