You should not use desmopressin if you have severe kidney disease or hyponatremia (low sodium levels in your body). You also should not take Nocdurna if you have severe thirst, uncontrolled hypertension, heart failure, high levels of a hormone that causes fluid retention, or if you take a diuretic or use steroid medication.
Limit your intake of water and other fluids while you are using desmopressin. Drinking too much water may lead to a serious, life-threatening electrolyte imbalance.
Call your doctor right away if you have signs of low sodium: headache, confusion, muscle cramps, severe weakness, vomiting, loss of coordination, and feeling restless or unsteady.
Before taking this medicine
You should not use desmopressin if you are allergic to it, or if you have:
severe kidney disease; or
hyponatremia (low sodium levels in your body).
You also should not take Nocdurna sublingual desmopressin if you have:
a disease or psychologic disorder that causes extreme or unusual thirst;
syndrome of inappropriate antidiuretic hormone secretion (SIADH, high levels of a hormone that causes fluid retention);
severe or uncontrolled high blood pressure;
heart failure; or
if you take a diuretic ("water pill") or use a steroid medicine (oral, nasal, inhaled, or injectable).
Desmopressin is not approved to treat bed-wetting in a child younger than 6 years old. Nocdurna is not approved for use in anyone younger than 18 years old.
Do not give  desmopressin to a child for any reason without medical advice.
Tell your doctor if you have ever had:
an electrolyte imbalance;
unusual thirst;
fluid retention;
congestive heart failure, coronary artery disease;
high blood pressure;
urination problems;
kidney disease; or
cystic fibrosis.
Tell your doctor if you are pregnant or breast-feeding.
