Usual Adult Dose for Urothelial Carcinoma:
MONOTHERAPY:
840 mg IV every 2 weeks OR 1200 mg IV every 3 weeks OR 1680 mg IV every 4 weeks until disease progression or unacceptable toxicity
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
Comments:
-Select cisplatin-ineligible patients with previously untreated locally advanced or metastatic UC for therapy with this drug based on the PD-L1 expression on tumor-infiltrating immune cells.
Use: For patients with locally advanced or metastatic urothelial carcinoma (UC) who are not eligible for cisplatin-containing chemotherapy and whose tumors express PD-L1 (PD-L1 stained tumor-infiltrating immune cells [IC] covering 5% or greater of the tumor area) OR are not eligible for any platinum-containing chemotherapy regardless of level of tumor PD-L1 expression OR have disease progression during or following any platinum-containing chemotherapy or within 12 months of neoadjuvant or adjuvant chemotherapy.
Usual Adult Dose for Non-Small Cell Lung Cancer:
MONOTHERAPY:
840 mg IV every 2 weeks OR 1200 mg IV every 3 weeks OR 1680 mg IV every 4 weeks until disease progression or unacceptable toxicity
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
IN COMBINATION WITH PLATINUM-BASED CHEMOTHERAPY:
1200 mg IV every 3 weeks for 4 or 6 cycles until disease progression or unacceptable toxicity; administer atezolizumab prior to chemotherapy and bevacizumab when given on the same day; following completion of 4 to 6 cycles of chemotherapy, and if bevacizumab is discontinued, the recommended dosage of atezolizumab is:
840 mg IV every 2 weeks OR 1200 mg IV every 3 weeks OR 1680 mg IV every 4 weeks until disease progression or unacceptable toxicity
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
Comments:
-When administering this drug in combination with chemotherapy or other antineoplastic drugs, administer this drug prior to chemotherapy or other antineoplastic drugs when given on the same day.
-Refer to the Prescribing Information for bevacizumab, paclitaxel, and carboplatin for recommended dosing information.
Uses:
Non-small cell lung cancer (NSCLC):
-As a single agent for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have high PD-L1 expression (PD-L1 stained greater than or equal to 50% of tumor cells [TC greater than or equal to 50%] or PD-L1 stained tumor-infiltrating immune cells [IC] covering greater than or equal to 10% of the tumor area [IC greater than or equal to 10%]), as determined by an approved test, with no EGFR or ALK genomic tumor aberrations
-In combination with bevacizumab, paclitaxel, and carboplatin, for the first-line treatment of adult patients with metastatic non-squamous NSCLC with no EGFR or ALK genomic tumor aberrations
-In combination with paclitaxel protein-bound and carboplatin, for the first-line treatment of adult patients with metastatic non-squamous NSCLC with no EGFR or ALK genomic tumor aberrations
-As a single-agent, for the treatment of adult patients with metastatic NSCLC who have disease progression during or following platinum-containing chemotherapy; patients with EGFR or ALK genomic tumor aberrations should have disease progression on approved therapy for NSCLC harboring these aberrations prior to receiving this drug
Usual Adult Dose for Breast Cancer:
840 mg IV on Days 1 and 15 followed by paclitaxel protein-bound 100 mg/m2 IV on Days 1, 8, and 15 for each 28-day cycle until disease progression or unacceptable toxicity
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
Comments:
-Atezolizumab and paclitaxel protein-bound may be discontinued for toxicity independently of each other.
-Refer to the Prescribing Information for paclitaxel protein-bound for recommended dosing information.
Use:
Triple-Negative Breast Cancer (TNBC): In combination with paclitaxel protein-bound for the treatment of adult patients with unresectable locally advanced or metastatic TNBC whose tumors express PD-L1 (PD-L1 stained tumor-infiltrating immune cells [IC] of any intensity covering 1% or greater of the tumor area), as determined by an approved test
Usual Adult Dose for Small Cell Lung Cancer:
1200 mg IV every 3 weeks in combination with carboplatin and etoposide until disease progression or unacceptable toxicity; following completion of 4 cycles of carboplatin and etoposide, the recommended dosage of atezolizumab is:
840 mg IV every 2 weeks OR 1200 mg IV every 3 weeks OR 1680 mg IV every 4 weeks until disease progression or unacceptable toxicity
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
Comments:
-When administering atezolizumab in combination with chemotherapy, administer it prior to chemotherapy when given on the same day.
-Refer to the prescribing information for the chemotherapy agents administered in combination with this drug for recommended dosing information.
Use: In combination with carboplatin and etoposide for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC)
Usual Adult Dose for Hepatocellular Carcinoma:
1200 mg IV over 60 minutes, followed by 15 mg/kg of bevacizumab on the same day, every 3 weeks until disease progression or unacceptable toxicity; if bevacizumab is discontinued for toxicity, the recommended dosage of atezolizumab is:
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
Comments:
-Refer to the Prescribing Information for bevacizumab prior to initiation.
Use: In combination with bevacizumab for the treatment of patients with unresectable or metastatic hepatocellular carcinoma (HCC) who have not received prior systemic therapy
Usual Adult Dose for Melanoma -- Metastatic:
Prior to initiating atezolizumab, patients should receive a 28 day treatment cycle of cobimetinib 60 mg orally once a day (21 days on and 7 days off) and vemurafenib 960 mg orally 2 times a day on Days 1 through 21, and vemurafenib 720 mg orally 2 times a day on Days 22 through 28 followed by atezolizumab 840 mg IV over 60 minutes every 2 weeks until disease progression or unacceptable toxicity, when administered with cobimetinib 60 mg orally once a day (21 days on and 7 days off) and vemurafenib 720 mg orally 2 times a day
NOTE: Administer the first infusion over 60 minutes; if well tolerated, administer subsequent infusions over 30 minutes
Comments:
-Refer to the Prescribing Information for cobimetinib and vemurafenib prior to initiation.
Use: In combination with cobimetinib and vemurafenib for the treatment of patients with BRAF V600 mutation-positive unresectable or metastatic melanoma
 Detailed Tecentriq dosage information
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Tecentriq injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
