Get emergency medical help if you have signs of an allergic reaction to Zoladex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
When you start treatment with Zoladex, your tumor symptoms may get worse for a short time. Worsening of a prostate tumor may increase pressure on your spinal cord or urinary tract. Tell your doctor right away if you have symptoms such as: back pain, painful or difficult urination, loss of movement in any part of your body, or loss of bowel or bladder control.
Call your doctor at once if you have:
pain, bruising, swelling, redness, oozing, or bleeding where the implant was injected;
dizziness, trouble breathing, feeling light-headed (like you might pass out);
high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;
high calcium levels - confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss;
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
signs of a blood clot - sudden numbness or weakness on one side of the body, chest pain, problems with vision or speech, pain or swelling in one leg.
Common Zoladex side effects may include:
hot flashes, sweating;
painful urination;
mood changes, increased or decreased interest in sex;
changes in sexual function, fewer erections than normal;
headache;
swelling in your hands or feet;
vaginal dryness, itching, or discharge;
changes in breast size; or
acne, mild skin rash or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Zoladex side effects (more detail)
