Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
Some medicines can cause unwanted or dangerous effects when used with lorlatinib. Tell your doctor about all your current medicines and any you start or stop using.
To make sure lorlatinib is safe for you, tell your doctor if you have:
heart problems, such as "AV block" (unless you have a pacemaker);
lung disease, breathing problems;
liver disease;
depression;
seizures; or
high cholesterol or triglycerides (a type of fat in the blood).
Lorlatinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
If you are a woman, do not use lorlatinib if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using lorlatinib.
This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because lorlatinib can harm an unborn baby.
Lorlatinib can make hormonal birth control less effective (birth control pills, injections, implants, skin patches, vaginal rings). Ask your doctor about the best form of birth control to use during treatment with this medicine.
Do not breastfeed while using this medicine, and for at least 7 days after your last dose.
How should I take lorlatinib?
Take lorlatinib exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Swallow the tablet whole and do not crush, chew, or break it.
Take the medicine at the same time each day, with or without food.
Do not use a broken or cracked tablet.
If you vomit shortly after taking lorlatinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
Store at room temperature away from moisture and heat.
Do not change your dose or stop taking lorlatinib without your doctor's advice.
