Some medicines can make Juxtapid much less effective when taken at the same time. If you take cholestyramine or colesevelam, take your lomitapide dose 4 hours before or 4 hours after you take the other medicine.
Tell your doctor about all your current medicines. Many drugs can interact with lomitapide, especially:
acetaminophen, isotretinoin, methotrexate, or tamoxifen;
an antidepressant;
antiviral medicine to treat HIV or hepatitis C;
heart or blood pressure medicine;
birth control pills;
an antibiotic - demeclocycline, doxycycline, minocycline, eravacycline, omadacycline, sarecycline, tetracycline;
a blood thinner - warfarin, Coumadin, Jantoven; or
cholesterol medication - atorvastatin or simvastatin.
This list is not complete and many other drugs may affect lomitapide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Juxtapid drug interactions (more detail)
