Do not use if you are pregnant. Use effective birth control, and ask your doctor how long to prevent pregnancy after you stop using zoledronic acid.
Zoledronic acid can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease. Call your doctor if you urinate less than usual, if you have swelling in your feet or ankles, or if you feel tired or short of breath.
Also call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, or severe pain in your joints, bones, or muscles.
Before taking this medicine
You should not be treated with zoledronic acid if you are allergic to it.
You also should not receive Reclast if you have:
low levels of calcium in your blood (hypocalcemia); or
severe kidney disease.
You should not be treated with zoledronic acid if are currently using any other bisphosphonate (such as alendronate, etidronate, ibandronate, pamidronate, risedronate, or tiludronate).
Tell your doctor if you have ever had:
kidney disease;
hypocalcemia;
thyroid or parathyroid surgery;
surgery to remove part of your intestine;
asthma caused by taking aspirin;
any condition that makes it hard for your body to absorb nutrients from food (malabsorption);
a dental problem (you may need a dental exam before you receive zoledronic acid);
if you are dehydrated; or
if you take a diuretic or "water pill".
Zoledronic acid can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease.
 zoledronic acid may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk.
You may need to have a negative pregnancy test before starting this treatment.
Do not use if you are pregnant. This medicine may harm an unborn baby or cause birth defects. Zoledronic acid can remain in your body for weeks or years after your last dose. Use effective birth control to prevent pregnancy while using this medicine. Talk with your doctor about the need to prevent pregnancy after you stop using zoledronic acid.
This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because zoledronic acid can harm an unborn baby.
You should not breastfeed while using zoledronic acid.
