(591,'nerlynx','Usual Adult Dose for Breast Cancer -- Adjuvant:\n240 mg orally once a day continuously for 1 year\nNOTE: Antidiarrheal prophylaxis is recommended during the first 2 cycles (56 days) of therapy and should be initiated with the first dose. Titrate loperamide to 1 to 2 bowel movements per day.\nMANUFACTURER SUGGESTED PROPHYLACTIC LOPERAMIDE DOSING:\n-Weeks 1 and 2 (days 1 through 14): 4 mg orally 3 times a day\n-Weeks 3 through 8 (days 15 through 56): 4 mg orally 2 times a day\n-Weeks 9 through 52 (days 57 through 365): 4 mg as needed (not to exceed 16 mg per day)\nUse: For the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer (to follow adjuvant trastuzumab-based therapy)\n Detailed Nerlynx dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose at the regular time. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include severe diarrhea or vomiting, stomach pain, increased thirst, decreased urination, dark urine, dizziness, or hot and dry skin.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nIf you also take an antacid: Wait at least 3 hours after taking the antacid before you take Nerlynx.\nIf you also take a stomach acid reducer: Take your Nerlynx dose 2 hours before or 10 hours after you take the other medicine (this includes cimetidine, famotidine, nizatidine, ranitidine, Axid, Pepcid, Tagamet, Zantac, and others).\nYou should not use certain stomach acid reducers, such as esomeprazole, lansoprazole, omeprazole, pantoprazole Nexium, Prevacid, Prilosec, Protonix, and others.\nOther drugs may interact with neratinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Nerlynx drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nerlynx: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere or ongoing diarrhea;\npain or burning when you urinate;\nkidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or\nliver problems - right-sided upper stomach pain, vomiting, tiredness, fever, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nYour cancer treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon Nerlynx side effects may include:\nkidney problems;\nabnormal liver function tests;\ndiarrhea, constipation;\npainful urination;\nnausea, vomiting, stomach pain, bloating;\nupset stomach, loss of appetite;\ndizziness, feeling weak or tired;\nnosebleed;\nrash, dry skin, problems with your fingernails or toenails;\ndry mouth, mouth sores;\nback pain, joint pain, muscle spasms;\nweight loss; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nerlynx side effects (more detail)\n','Nerlynx (neratinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.\nNerlynx is used alone or with other medicines to treat early-stage HER2-positive breast cancer. Nerlynx is also used to treat HER2-positive breast cancer that is advanced or has spread to other parts of the body (metastatic).\nNerlynx is used for breast cancer only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.\nNerlynx is usually given after you have been treated with another medicine called trastuzumab (Herceptin).\n','Nerlynx can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be given anti-diarrhea medications for the first 2 months of treatment with Nerlynx.\nCall your doctor if you are sick with severe diarrhea, or you also have weakness, dizziness, or a fever.\nBefore taking this medicine\nTo make sure Nerlynx is safe for you, tell your doctor if you have ever had:\nliver disease.\nYou may need to have a negative pregnancy test before starting this treatment.\nNeratinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.\nIf you are a woman, do not use Nerlynx if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.\nIf you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.\nTell your doctor right away if a pregnancy occurs while either the mother or the father is using Nerlynx.\nDo not breastfeed while using this medicine, and for at least 1 month after your last dose.\nHow should I take Nerlynx?\nTake Nerlynx exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nThe usual dose of Nerlynx is 6 tablets taken once daily. Take the medicine with food, at the same time each day.\nYou may need to take this medicine daily for up to one year. Nerlynx is sometimes taken daily in 21-day treatment cycles until the medicine stops working or until you have serious side effects.\nYour doctor will determine how long to treat you with this medicine. Follow your doctor\'s dosing instructions very carefully.\nSwallow the tablet whole and do not crush, chew, or break it.\nNerlynx can cause severe diarrhea, which can be life-threatening if it leads to dehydration. For the first 2 months of treatment with Nerlynx, you may need to take medication to prevent or quickly treat diarrhea.\nYour doctor may recommend you have an anti-diarrhea medicine such as loperamide (Imodium) available at all times while you are taking Nerlynx. Take the anti-diarrhea medicine exactly as prescribed by your doctor.\nTo best control diarrhea, you may need to follow a special diet. Get familiar with the list of foods you should eat or avoid to help control diarrhea. You may also need to drink extra fluids to keep from getting dehydrated.\nTell your doctor if you have more than 2 bowel movements in 1 day.\nCall your doctor if you are sick with severe diarrhea, or you also have weakness, dizziness, or a fever. You may need to stop taking this medicine for a short time.\nYou may need frequent blood tests.\nStore at room temperature away from moisture and heat.\n','Grapefruit may interact with neratinib and lead to unwanted side effects. Avoid the use of grapefruit products.\nAsk your doctor before using an antacid or stomach acid reducing medicine. Use only the type your doctor recommends.\n');
INSERT INTO `drugs` VALUES (592,'neulasta','Use Neulasta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. This medicine should not be given within 14 days before or 24 hours after you receive chemotherapy.\nNeulasta is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don\'t understand all instructions.\nPrepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.\nCarefully follow your doctor\'s instructions when giving Neulasta to a child who weighs less than 99 pounds (45 kilograms). The correct dose for a child this size cannot be accurately measured using the prefilled syringe.\nYou may need medical tests to help your doctor determine how long to treat you with this medicine.\nStore the prefilled syringe in its original package in the refrigerator, protected from light. Do not shake or freeze.\nTake the syringe out of the refrigerator and let it reach room temperature for 15 to 30 minutes before injecting your dose. If a syringe has become frozen, thaw it in a refrigerator. Do not use any syringe that has been frozen more than one time.\nDo not use a syringe that has been left at room temperature for longer than 48 hours.\nThe Neulasta Onpro Injector is a special device placed on the skin that delivers your pegfilgrastim dose at a specific time. You will need to wear the device for 27 hours before the dose begins. The timed dose will then be released from the device slowly over a 45-minute period.\nKeep Neulasta Onpro refrigerated until you are ready to wear it. Do not use an Onpro device that has been left out of a refrigerator for longer than 12 hours.\nWhile wearing Neulasta Onpro, you or a caregiver will need to check the device to make sure it is working properly.\nEach prefilled syringe or Onpro Injector is for one use only. Throw it away after one use, even if there is still medicine left inside.\nUse a needle and syringe only once and then place them in a puncture-proof \"sharps\" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.\n Detailed Neulasta dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss an injection, or if you have a problem with the Onpro device.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with pegfilgrastim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Neulasta drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Neulasta: hives, skin rash, sweating, warmth or tingly feeling; dizziness, fast heartbeats; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.\nCapillary leak syndrome is a rare but serious side effect of pegfilgrastim. Call your doctor right away if you have signs of this condition, which may include: decreased urination, tiredness, dizziness or light-headed feeling, trouble breathing, and sudden swelling, puffiness, or feeling of fullness.\nCall your doctor at once if you have:\nsudden or severe pain in your left upper stomach spreading up to your shoulder;\nsudden and severe pain in your chest, stomach, or back;\nsevere or ongoing pain anywhere in your body;\nfever, tiredness;\nshortness of breath, rapid breathing;\npale skin, easy bruising, unusual bleeding;\nbruising, swelling, or a hard lump where the medicine was injected; or\nkidney problems - little or no urination, pink or dark urine, swelling in your face or lower legs.\nYour cancer treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon Neulasta side effects may include:\nbone pain; or\npain in your arms or legs.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Neulasta side effects (more detail)\n','Neulasta (pegfilgrastim) is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.\nNeulasta is a prescription medicine used to prevent neutropenia (a lack of certain white blood cells) that is caused by receiving chemotherapy.\nNeulasta helps reduce the chance of infections.\n','Before using Neulasta, tell your doctor if you have sickle cell disorder, chronic myeloid leukemia, myelodysplasia (also called \"preleukemia\"), or if you are allergic to latex.\nFollow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nDo not self-inject Neulasta if you do not fully understand how to give the injection and properly dispose of used needles and syringes.\nNeulasta is usually given once per chemotherapy cycle. It should not be given within 14 days before or 24 hours after you receive chemotherapy.\nBefore taking this medicine\nYou should not use Neulasta if you are allergic to pegfilgrastim or filgrastim (Neupogen).\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\nsickle cell disorder;\nkidney disease;\nchronic myeloid leukemia;\nradiation treatment;\nmyelodysplasia syndrome (also called \"preleukemia\"); or\na latex allergy.\nTell your doctor if you are pregnant or breastfeeding.\n','When using Neulasta Onpro: Avoid traveling, driving, or operating machinery while wearing the device.\n'),(593,'neupro','Usual Adult Dose for Parkinson\'s Disease:\nInitial doses:\nEarly-stage Parkinson\'s disease: Apply 2 mg topically once a day\nAdvanced-stage Parkinson\'s disease: Apply 4 mg topically once a day\nMaintenance dose: Increase weekly in 2 mg/24 hours increments if additional therapeutic effect is needed\nLowest effective dose: 4 mg/24 hours\nMaximum dose for Early-stage Parkinson\'s disease: 6 mg/24 hours\nMaximum dose for Advanced-stage Parkinson\'s disease: 8 mg/24 hours\nComments:\n-Upon discontinuation, reduce the daily dose by a maximum of 2 mg every 24 hours, if possible; reduce the dose every other day until withdrawal is complete.\nUse: Treatment of Parkinson\'s disease\nUsual Adult Dose for Restless Legs Syndrome:\nInitial dose: Apply 1 mg topically once a day\nMaintenance dose: Increase weekly in 1 mg/24 hours increments if additional therapeutic effect is needed\nLowest effective dose: 1 mg/24 hours\nMaximum dose: 3 mg/24 hours\nComments:\n-Upon discontinuation, reduce the daily dose by a maximum of 1 mg every 24 hours, if possible; reduce the dose every other day until withdrawal is complete\nUse: Treatment of moderate-to-severe primary Restless Legs Syndrome\n Detailed Neupro dosage information\nWhat happens if I miss a dose?\nIf you forget to change a patch on your scheduled day, remove and replace the patch as soon as you remember. Wear the new patch until your next regular patch-changing time. Do not change your schedule, even if you wear the new patch for less than 24 hours.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using Neupro with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nOther drugs may interact with rotigotine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Neupro drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Neupro: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere skin irritation that does not clear up within several hours after removing a skin patch;\nextreme drowsiness, falling asleep suddenly, even after feeling alert;\na light-headed feeling, like you might pass out;\nagitation, confusion, hallucinations, paranoia (most commonly in elderly people);\nfast heart rate;\nincreased sexual urges, unusual urges to gamble, or other intense urges;\nunusual thoughts or behavior; or\nuncontrolled muscle movements.\nSome people using Neupro have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.\nCommon Neupro side effects may include:\nnausea, vomiting, loss of appetite;\nheadache, dizziness, drowsiness;\nvision problems;\nswelling in your hands or feet, rapid weight gain;\nincreased sweating;\nsleep problems (insomnia); or\nredness, itching, or swelling where a patch was worn.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Neupro side effects (more detail)\n','Neupro (rotigotine) has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson\'s disease.\nNeupro skin patches are used to treat symptoms of Parkinson\'s disease, such as stiffness, tremors, muscle spasms, and poor muscle control.\nNeupro is also used to treat restless legs syndrome (RLS).\n','Some people using Neupro have fallen asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. If you are unsure of how rotigotine will affect you, be careful if you drive or do anything that requires you to be awake and alert.\nYou may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication. Talk with your doctor if you believe you have any intense or unusual urges while using Neupro.\nDo not stop using Neupro suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using Neupro. Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by rotigotine. Tell your doctor if you regularly use any of these other medicines. Drinking alcohol can increase certain side effects of rotigotine. The Neupro patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. Neupro may cause hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you have hallucinations.\nFollow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use Neupro if you are allergic to rotigotine.\nTo make sure Neupro is safe for you, tell your doctor if you have:\nasthma or a sulfite allergy;\nhigh or low blood pressure;\nheart problems;\nkidney disease;\nschizophrenia, bipolar disorder, or psychosis;\nnarcolepsy or other sleep disorder; or\nif you feel light-headed or nauseated when you stand up.\nPeople with Parkinson\'s disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nYou should not breast-feed while using rotigotine.\nHow should I use Neupro?\nUse Neupro skin patches exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nApply the patch to clean, dry, and hairless skin. Avoid placing the patch where it will be rubbed by a waistband or tight clothing. Press the patch firmly into place for about 30 seconds. You may leave the patch on while bathing, showering, or swimming.\nRemove the skin patch after 24 hours and replace it with a new one. Choose a different place on your body to wear the patch each time you put on a new one. Do not use the same skin area twice within 14 days.\nIf a patch falls off, put a new patch on a different place on your body and wear it the rest of the day. Then replace the patch the next day at your regular time.\nWash your hands with soap and water after applying or removing the patch.\nKeep used and unused Neupro skin patches out of the reach of children or pets.\nIf you are using Neupro for RLS, call your doctor if your symptoms get worse, or if they start earlier in the day than usual.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Neupro.\nThe Neupro patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test.\nDo not stop using Neupro suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.\nKeep the skin patch in its sealed pouch until you are ready to use it. Store the pouches at room temperature away from heat and moisture.\nAfter removing a patch, fold it in half so it sticks together and throw it away in a place where children or pets cannot get to it.\n','Drinking alcohol with this medicine can increase side effects.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nAvoid applying a patch to skin that is irritated, or to skin where you have applied lotion, oil, cream, ointment, or powder.\nDo not expose the skin patch to heat while you are wearing it. This includes a hot tub, heating pad, sauna, or heated water bed. Heat can increase the amount of drug absorbed through your skin and may cause harmful effects.\n'),(594,'neurontin','Usual Adult Dose for Epilepsy:\nInitial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three\nMaintenance dose: 300 to 600 mg orally 3 times a day\nMaximum dose: 3600 mg orally daily (in 3 divided doses)\n-Maximum time between doses in the 3 times a day schedule should not exceed 12 hours\nComment:\n-May be taken with or without food.\n-Half-tablets not used within 28 days of breaking the scored tablet should be discarded.\nUse: Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization\nUsual Adult Dose for Postherpetic Neuralgia:\n-Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three\n-Titrate up as needed for pain relief\n-Maximum dose: 1800 mg per day (600 mg orally 3 times a day)\nCOMMENT:\n-May be taken with or without food.\n-Half-tablets not used within 28 days of breaking the scored tablet should be discarded.\nUsual Pediatric Dose for Epilepsy:\nLess than 3 years: Not recommended\nGreater than or equal to 3 and less than 12 years:\nStarting Dose: Ranges from 10 to 15 mg/kg/day in 3 divided doses\nEffective Dose: Reached by upward titration over a period of approximately 3 days; the effective dose in patients 5 years of age and older is 25 to 35 mg/kg/day in divided doses (3 times a day). The effective dose in pediatric patients ages 3 and 4 years is 40 mg/kg/day and given in divided doses (3 times a day). Gabapentin may be administered as capsule, or tablet, or using combinations of these formulations. Dosages up to 50 mg/kg/day have been well tolerated in a long term clinical study. The maximum time interval between doses should not exceed 12 hours.\nGreater than 12 years:\n-Initial dose: 300 mg orally on day one, 300 mg orally 2 times a day on day two, then 300 mg orally 3 times a day on day three\n-Maintenance dose: 900 to 1800 mg orally in 3 divided doses; the dose may be increased up to 1800 mg/day. Dosages up to 2400 mg/day have been well tolerated in long term clinical studies. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. The maximum time between doses in the three times a day schedule should not exceed 12 hours.\nUse: Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization in patients 3 years of age and older\n Detailed Neurontin dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using Neurontin with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, cold or allergy medicine, a muscle relaxer, or medicine for anxiety or seizures.\nother drugs may interact with gabapentin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Neurontin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Neurontin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSeek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, upper stomach pain, or yellowing of your skin or eyes.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\nweak or shallow breathing;\nblue-colored skin, lips, fingers, and toes;\nconfusion, extreme drowsiness or weakness;\nproblems with balance or muscle movement;\nunusual or involuntary eye movements; or\nincreased seizures.\nGabapentin can cause life-threatening breathing problems. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Breathing problems may be more likely in older adults or in people with COPD.\nSome side effects are more likely in children taking Neurontin. Contact your doctor if the child taking this medicine has any of the following side effects:\nchanges in behavior;\nmemory problems;\ntrouble concentrating; or\nacting restless, hostile, or aggressive.\nCommon Neurontin side effects may include:\nfever, chills, sore throat, body aches, unusual tiredness;\njerky movements;\nheadache;\ndouble vision;\nswelling of your legs and feet;\ntremors;\ntrouble speaking;\ndizziness, drowsiness, tiredness;\nproblems with balance or eye movements; or\nnausea, vomiting.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Neurontin side effects (more detail)\n','Neurontin (gabapentin) is an anti-epileptic drug, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.\nNeurontin is used in adults to treat neuropathic pain (nerve pain) caused by herpes virus or shingles (herpes zoster).\nNeurontin is also used to treat seizures in adults and children who are at least 3 years old.\nUse only the brand and form of gabapentin your doctor has prescribed. Check your medicine each time you get a refill to make sure you receive the correct form.\n','Do not stop using Neurontin suddenly, even if you feel fine.\nGabapentin can cause life-threatening breathing problems, especially if you already have a breathing disorder or if you use other medicines that can make you drowsy or slow your breathing. Seek emergency medical attention if you have very slow breathing.\nSome people have thoughts about suicide or behavior changes while taking Neurontin. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\nBefore taking this medicine\nYou should not use Neurontin if you are allergic to gabapentin.\nTo make sure Neurontin is safe for you, tell your doctor if you have ever had:\nbreathing problems or lung disease, such as chronic obstructive pulmonary disease (COPD);\nkidney disease (or if you are on dialysis);\ndiabetes;\ndepression, a mood disorder, or suicidal thoughts or actions;\na drug addiction;\na seizure (unless you take Neurontin to treat seizures);\nliver disease;\nheart disease; or\n(for patients with RLS) if you are a day sleeper or work a night shift.\nSome people have thoughts about suicide while taking this medicine. Children taking Neurontin may have behavior changes. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nSeizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking Neurontin for seizures without your doctor\'s advice, and tell your doctor right away if you become pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of gabapentin on the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nHow should I take Neurontin?\nTake Neurontin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nIf your doctor changes your brand, strength, or type of gabapentin, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of gabapentin you receive at the pharmacy.\nNeurontin can be taken with or without food.\nIf you break a tablet and take only half of it, take the other half at your next dose. Any tablet that has been broken should be used as soon as possible or within a few days.\nSwallow the capsule or tablet whole and do not crush, chew, break, or open it.\nMeasure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nDo not stop using Neurontin suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor\'s instructions about tapering your dose.\nIn case of emergency, wear or carry medical identification to let others know you have seizures.\nThis medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Neurontin.\nStore Neurontin tablets and capsules at room temperature away from light and moisture.\nStore the liquid medicine in the refrigerator. Do not freeze.\n','Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\nAvoid taking an antacid within 2 hours before you take Neurontin. Antacids can make it harder for your body to absorb gabapentin.\nAvoid drinking alcohol while taking Neurontin.\n'),(595,'nexium','Use Nexium exactly as directed on the label, or as prescribed by your doctor.\nTake each dose with a full glass (8 ounces) of water.\nNexium should be taken at least one hour before a meal.\nDo not crush or chew a delayed-release capsule. However to make swallowing easier, you may open the capsule and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow right away without chewing. Do not save the mixture for later use.\nThe capsule can be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nEsomeprazole is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.\nUse this medicine for the full prescribed length of time, even if your symptoms quickly improve.\nCall your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using esomeprazole.\nSome conditions are treated with a combination of esomeprazole and antibiotics. Use all medications as directed.\nStore at room temperature away from moisture and heat.\n Detailed Nexium dosage information\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your current medicines. Many drugs can affect esomeprazole, especially:\ncilostazol;\nclopidogrel;\ndiazepam;\ndigoxin;\nerlotinib;\niron-containing medicines (ferrous fumarate, ferrous gluconate, ferrous sulfate, and others);\nmethotrexate;\nmycophenolate mofetil;\nrifampin;\nSt. John\'s wort;\ntacrolimus;\nwarfarin (Coumadin, Jantoven);\nantifungal medication - ketoconazole, voriconazole; or\nHIV/AIDS medication - atazanavir, nelfinavir, saquinavir.\nThis list is not complete and many other drugs may interact with esomeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Nexium drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction ro Nexium: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\nseizure (convulsions);\nkidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;\nlow magnesium - dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or\nnew or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.\nTaking esomeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.\nIf you use esomeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.\nCommon Nexium side effects may include:\nheadache;\ndiarrhea;\nnausea, stomach pain, gas, constipation; or\ndry mouth.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nexium side effects (more detail)\n','Nexium (esomeprazole magnesium) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.\nNexium is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).\nNexium may also be given to prevent gastric ulcer caused by infection with Helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).\nNexium is not for immediate relief of heartburn symptoms.\n','Nexium can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.\nDiarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.\nEsomeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.\nYou may be more likely to have a broken bone while taking this medicine long term or more than once per day.\nBefore taking this medicine\nYou should not use Nexium if you are allergic to esomeprazole or to similar medicines such as lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), or rabeprazole (AcipHex).\nHeartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.\nYou should not use this medicine if you have had breathing or kidney problems.\nTell your doctor if you have ever had:\nsevere liver disease;\nlupus;\nosteoporosis or low bone mineral density (osteopenia); or\nlow levels of magnesium in your blood.\nYou may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.\nAsk a doctor before using this medicine if you are pregnant or breastfeeding.\n','This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\n'),(596,'nexletol','\nTake Nexletol exactly as your healthcare provider tells you to take it. Check with your healthcare provider or pharmacist if you are not sure.\nTake 1 Nexletol tablet by mouth each day.\nYou may take Nexletol with or without food.\nIf you take too much Nexletol, call your poison control center at 1-800-222-1222 or go to the nearest hospital emergency room right away.\n Detailed Nexletol dosage information\n',NULL,'Nexletol may cause serious side effects, including:\nincreased levels of uric acid in your blood (hyperuricemia). This can happen within 4 weeks of you starting Nexletol and continue throughout your treatment. Your healthcare provider may monitor your blood uric acid levels while you are taking Nexletol. High levels of blood uric acid may lead to gout. Call your healthcare provider if you have the following symptoms of hyperuricemia and gout:\nsevere foot pain especially in the toe joint\nwarm joints\nswelling\ntender joints\njoint redness\nGout may happen more in people who have had gout before but also can happen in people who have never had it before.\ntendon rupture or injury. Tendon problems can happen in people who take Nexletol. Tendons are tough cords of tissue that connect muscles to bones. Symptoms of tendon problems may include pain, swelling, tears, and inflammation of tendons including the arm, shoulder, and back of the ankle (Achilles).\nTendon rupture can happen while you are taking Nexletol. Tendon ruptures can happen within days or months of starting Nexletol.\nThe risk of getting tendon problems while you take Nexletol is higher if you:\nare over 60 years of age\nare taking antibiotics (fluoroquinolones)\nhave had tendon problems\nare taking steroids (corticosteroids)\nhave renal failure\nStop taking Nexletol immediately and get medical help right away if you get any of the following signs or symptoms of a tendon rupture:\nhear or feel a snap or pop in a tendon area\nbruising right after an injury in a tendon area\nunable to move the affected area or put weight on the affected area\nStop taking Nexletol until tendon rupture has been ruled out by your healthcare provider. Avoid exercise and using the affected area. The most common areas of pain and swelling are the rotator cuff (the shoulder), the biceps tendon (upper arm), and Achilles tendon at the back of the ankle. This can happen with other tendons.\nTalk to your healthcare provider about the risk of tendon rupture with continued use of Nexletol. You may need a different lipid-lowering medicine to treat your cholesterol levels.\n \nThe most common side effects of Nexletol include:\nsymptoms of the common cold, flu, or flu-like symptoms\nback pain\nstomach pain\nincreased liver enzymes\nmuscle spasms\npain in shoulder, legs, or arms\nanemia\nbronchitis\nTell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Nexletol. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nexletol side effects (more detail)\nHow should I store Nexletol?\nStore Nexletol in the original package at room temperature between 68ºF to 77ºF (20ºC to\n25ºC).\nDo not throw away the packet that helps to keep your medicine dry (desiccant).\nKeep Nexletol and all medicines out of the reach of children.\nGeneral information about the safe and effective use of Nexletol.\nMedicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Nexletol for a condition for which it was not prescribed. Do not give Nexletol to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Nexletol that is written for healthcare professionals.\nWhat are the ingredients in Nexletol?\nActive Ingredient: bempedoic acid\nInactive Ingredients: colloidal silicon dioxide, hydroxyl propyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate\ntablet coating: partially hydrolyzed polyvinyl alcohol, polyethylene glycol, talc, and titanium dioxide\n','Nexletol is a prescription medicine used along with diet and other lipid-lowering medicines in the treatment of adults with:\nheterozygous familial hypercholesterolemia (HeFH). HeFH is an inherited condition that causes high levels of “bad” cholesterol called low density lipoprotein (LDL).\nknown heart disease who need additional lowering of “bad” cholesterol (LDL-C) levels.\nIt is not known if Nexletol can decrease problems from high cholesterol, such as heart attacks, stroke, death, or other heart problems.It is not known if Nexletol is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis.\nIt is not known if Nexletol is safe and effective in people with severe liver problems.\nIt is not known if Nexletol is safe and effective in children under 18 years of age.\n',NULL,NULL),(597,'nexlizet','\nTake Nexlizet exactly as your healthcare provider tells you to take it. Check with your healthcare provider or pharmacist if you are not sure.\nTake 1 Nexlizet tablet by mouth each day.\nSwallow the tablet whole. Do not cut, chew, or crush the tablet.\nYou may take the tablet with or without food.\nIf you take a medicine that lowers cholesterol by binding bile acids, such as colesevelam or cholestyramine, take Nexlizet at least 2 hours before or 4 hours after you take bile acid binding medicines. Ask your healthcare provider if you are not sure if you take these medicines.\nIf you take too much Nexlizet, call your poison control center at 1-800-222-1222 or go to the nearest hospital emergency room right away.\n Detailed Nexlizet dosage information\n',NULL,'Nexlizet may cause serious side effects, including:\nincreased levels of uric acid in your blood (hyperuricemia). This can happen within 4 weeks of you starting Nexlizet and continue throughout your treatment. Your healthcare provider may monitor your blood uric acid levels while you are taking Nexlizet. High levels of blood uric acid may lead to gout. Call your healthcare provider if you have the following symptoms of hyperuricemia and gout:\nsevere foot pain especially in the toe joint\nwarm joints\nswelling\ntender joints\njoint redness\nGout may happen more in people who have had gout before but also can happen in people who have never had it before.\ntendon rupture or injury. Tendon problems can happen in people who take bempedoic acid, one of the medicines in Nexlizet. Tendons are tough cords of tissue that connect muscles to bones. Symptoms of tendon problems may include pain, swelling, tears, and inflammation of tendons including the arm, shoulder, and back of the ankle (Achilles).\nTendon rupture can happen while you are taking Nexlizet. Tendon ruptures can happen within weeks or months of starting Nexlizet.\nThe risk of getting tendon problems while you take Nexlizet is higher if you:\nare over 60 years of age\nare taking antibiotics (fluoroquinolones)\nhave had tendon problems\nare taking steroids (corticosteroids)\nhave renal failure\nStop taking Nexlizet immediately and get medical help right away if you get any of the following signs or symptoms of a tendon rupture:\nhear or feel a snap or pop in a tendon area\nbruising right after an injury in a tendon area\nunable to move the affected area or put weight on the affected area\nStop taking Nexlizet until tendon rupture has been ruled out by your healthcare provider. The most common areas of pain and swelling are the rotator cuff (the shoulder), the biceps tendon (upper arm), and the Achilles tendon at the back of the ankle. This can happen with other tendons.\nTalk to your healthcare provider about the risk of tendon rupture with continued use of Nexlizet. You may need a different lipid lowering medicine to treat your cholesterol levels.\nThe most common side effects include:\nsymptoms of the common cold, flu, or flu-like symptoms\nback pain\nbronchitis\nanemia\ndiarrhea\nmuscle spasms\nstomach pain\npain in shoulder, legs, or arms\nincreased liver enzymes\nfatigue\nTell your healthcare provider if you have any side effect that bothers you or that does not go away.\nThese are not all the possible side effects. Ask your healthcare provider or pharmacist for more information.\nCall your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nexlizet side effects (more detail)\nHow should I store Nexlizet?\nStore Nexlizet in the original package at room temperature between 68ºF to 77ºF (20ºC to 25ºC).\nProtect from heat and moisture.\nDo not throw away the packet that helps to keep your medicine dry (desiccant).\nNexlizet comes in a bottle with a child-resistant cap.\nKeep all medicines out of the reach of children and pets.\nGeneral information about the safe and effective use of Nexlizet.\nMedicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it wasnot prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.\nWhat are the ingredients in Nexlizet?\nActive Ingredients: bempedoic acid and ezetimibe\nInactive Ingredients: colloidal silicon dioxide, hydroxy propyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone K30, sodium lauryl sulfate, sodium starch glycolate\nTablet coating: FD&C Blue #1/Brilliant Blue FCF Aluminum Lake, FD&C Blue #2/Indigo Carmine Aluminum Lake, glyceryl monocaprylocaprate, partially hydrolyzed polyvinyl alcohol, sodium lauryl sulfate, talc, and titanium dioxide\n','Nexlizet is a prescription medicine that contains two cholesterol lowering medicines: bempedoic acid and ezetimibe. Nexlizet is used along with diet and other lipid-lowering medicines in the treatment of adults with:\nheterozygous familial hypercholesterolemia (HeFH). HeFH is an inherited condition that causes high levels of “bad” cholesterol called low density lipoprotein (LDL).\nknown heart disease who need additional lowering of “bad” cholesterol (LDL-C) levels.\nIt is not known if Nexlizet can decrease problems from high cholesterol, such as heart attacks, stroke, death, or other heart problems.\nIt is not known if Nexlizet is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis.\nIt is not known if Nexlizet is safe and effective in people with moderate to severe liver problems.\nIt is not known if Nexlizet is safe and effective in children under 18 years of age.\nWho should not take Nexlizet?\nYou should not take Nexlizet if you are allergic to ezetimibe tablets. Ezetimibe, one of the active ingredients in Nexlizet, can cause serious allergic reactions such as anaphylaxis, angioedema, rash, and urticaria. Stop taking Nexlizet, call your healthcare provider or go to the nearest hospital emergency room right away if you have any signs or symptoms of an allergic reaction including:\nswelling of your face, lips, mouth or tongue\nwheezing\nsevere itching\nfast heart beat or pounding in your chest\ntrouble breathing\ndizziness or fainting\nSee the end of this leaflet for a complete list of ingredients.\n',NULL,NULL),(598,'nexplanon',NULL,'Certain other medicines or herbal products may make etonogestrel less effective, which could result in pregnancy. You may need to use a non-hormonal form of back-up birth control (such as condoms with spermicide) while you are taking certain medicine, and for up to 28 days after stopping the medicine.\nTell your doctor about all your current medicines and any other medicines you start or stop using, especially:\naprepitant;\nbosentan;\ngriseofulvin;\nrifampin;\nSt. John\'s wort;\ntopiramate;\nmedicine to treat hepatitis C, HIV, or AIDS;\na barbiturate - butabarbital, secobarbital, phenobarbital (Solfoton); or\nseizure medicine - carbamazepine, felbamate, oxcarbazepine, phenytoin.\nThis list is not complete. Other drugs may interact with etonogestrel, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Nexplanon drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nexplanon: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nwarmth, redness, swelling, or oozing where the implant was inserted;\nsevere pain or cramping in your pelvic area (may be only on one side);\nsigns of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;\nsigns of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;\nheart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;\nincreased blood pressure - severe headache, blurred vision, pounding in your neck or ears;\nswelling in your hands, ankles, or feet;\njaundice (yellowing of the skin or eyes);\na breast lump; or\nsymptoms of depression - sleep problems, weakness, tired feeling, mood changes.\nCommon Nexplanon side effects may include:\npain where the implant was inserted;\nchanges in your menstrual periods;\nvaginal itching or discharge;\nacne, mood changes, weight gain;\nbreakthrough bleeding, menstrual cramps;\nnausea, stomach pain;\nbreast pain;\nheadache, dizziness; or\nflu-like symptoms, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nexplanon side effects (more detail)\n','Nexplanon (etonogestrel) is a hormone implant that prevents ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.\nNexplanon is radiopaque implant used as contraception to prevent pregnancy. Etonogestrel is contained in a small plastic rod that is implanted into the skin of your upper arm. The medicine is released slowly into the body.\nThe Nexplanon rod can remain in place and provide continuous contraception for up to 3 years.\nNexplanon implants contain a small amount of barium sulfate so that the implant can be seen by X-ray.\n','Do not use Nexplanon if you are pregnant or if you have recently had a baby.\nYou should not use a Nexplanon implant if you have: undiagnosed vaginal bleeding, liver disease or liver cancer, if you will be having major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.\nUsing a Nexplanon implant can increase your risk of blood clots, stroke, or heart attack.\nSmoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not smoke while using a Nexplanon implant.\n','You should not smoke while using a Nexplanon implant.\nNexplanon will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.\n'),(599,'niacin','Use niacin exactly as directed on the label, or as prescribed by your doctor. Read all medication guides or instruction sheets.\nNiacin can cause flushing (warmth, itching, redness, or tingly feeling under your skin). These effects should disappear over time as you keep taking the medicine. Flushing may be worse if you drink alcohol or hot beverages shortly after taking niacin.\nSwallow the capsule or tablet whole and do not crush, chew, break, or open it.\nYour dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes.\nIf you stop taking niacin for any length of time, talk with your doctor before starting the medication again. You may need to restart the medication at a lower dose.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.\nNiacin is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.\nYour doctor may recommend you take aspirin or an NSAID (such as ibuprofen, Advil, or Aleve) to help prevent flushing. Keep using these medicines for as long as your doctor has prescribed.\nStore at room temperature away from moisture and heat.\n Detailed Niacin dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your other medicines, especially:\nstatin cholesterol medication;\nheart or blood pressure medication; or\nother medicines that lower blood pressure.\nThis list is not complete. Other drugs may interact with niacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Niacin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to niacin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nirregular heartbeats;\nsevere warmth or redness under your skin;\nvision problems; or\njaundice (yellowing of the skin or eyes).\nCommon niacin side effects may include:\nflushing (sudden warmth, redness, or tingly feeling);\nupset stomach, vomiting, diarrhea;\nabnormal liver function tests;\nitching, dry skin;\ncough;\nskin discoloration; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Niacin side effects (more detail)\n','Niacin, also called nicotinic acid, is a B vitamin (vitamin B3). It occurs naturally in plants and animals, and is also added to many foods as a vitamin supplement. It is also present in many multiple vitamins and nutritional supplements.\nNiacin is used to lower blood levels of \"bad\" cholesterol (low-density lipoprotein, or LDL) and triglycerides, and increase levels of \"good\" cholesterol (high-density lipoprotein, or HDL).\nNiacin may also be used for purposes not listed in this medication guide.\n','You should not take niacin if you have severe liver disease, a stomach ulcer, or active bleeding.\nNiacin can cause certain side effects, such as flushing (warmth, itching, redness, or tingly feeling under your skin). These effects can be made worse if you drink alcohol or hot beverages shortly after you take this medicine. These effects should disappear over time as you keep taking the medication.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\nAvoid taking colestipol (Colestid) or cholestyramine (Locholest, Prevalite, Questran) at the same time you take niacin. If you take either of these other medications, take them at least 4 to 6 hours before or after you take this medicine.\nNiacin is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.\nBefore taking this medicine\nYou should not take niacin if you are allergic to it.\nTo make sure you can safely take niacin, tell your doctor if you have ever had:\nsevere liver disease;\na stomach ulcer; or\nactive bleeding.\nTell your doctor if you have ever had:\nliver disease;\nheart disease, chest pain (angina);\ngout; or\ndiabetes.\nIt is not known whether niacin will harm an unborn baby. You may not be able to use this medicine during pregnancy. Tell your doctor right away if you become pregnant.\nYou should not breastfeed while using this medicine.\nNiacin is not approved for use by anyone younger than 18 years old.\n','Avoid drinking alcohol. It may increase your risk of liver damage, and can also worsen the flushing effects of niacin.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nAvoid eating foods high in fat or cholesterol, or niacin will not be as effective.\n'),(600,'niaspan','Use Niaspan ER exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.\nNiaspan ER is sometimes taken at bedtime with a low-fat snack. Follow your doctor\'s instructions.\nNiaspan ER can cause certain side effects, such as flushing (warmth, itching, redness, or tingly feeling under your skin). These effects can be made worse if you drink alcohol or hot beverages shortly after you take Niaspan ER. These effects should disappear over time as you keep taking the medication.\nTake Niaspan ER with a full glass of cold or cool water. Taking the medication with a hot drink may increase your risk of side effects such as flushing. Do not crush, chew, break, or open an extended-release Niaspan ER tablet. Swallow it whole. Breaking or opening the tablet may cause too much of the drug to be released at one time. Extended-release tablets contain higher strengths of niacin than the regular tablets.\nNiaspan ER can cause you to have unusual results with certain medical tests (urine tests). Tell any doctor who treats you that you are using this medicine.\nIf you stop taking Niaspan ER for any length of time, talk with your doctor before starting the medication again. You may need to restart the medication at a lower dose.\nWhile using Niaspan ER, you may need blood tests at your doctor\'s office. Your kidney or liver function may also need to be checked. Visit your doctor regularly.\nNiaspan ER is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.\nStore at room temperature away from moisture and heat.\n Detailed Niaspan dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Be sure to take the missed dose with food if you normally take your Niaspan ER dose with a meal or snack.\nSkip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, dizziness, itching, vomiting, upset stomach, and flushing (warmth, redness, or tingly feeling).\n','Tell your doctor about all other cholesterol-lowering drugs you are taking with Niaspan ER, especially atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), or simvastatin (Zocor, Simcor, Vytorin, Juvisync).\nAsk a doctor or pharmacist if it is safe for you to use Niaspan ER if you are also using any of the following drugs:\na blood thinner such as warfarin (Coumadin, Jantoven);\nmultivitamins or mineral supplements that contain niacin;\nblood pressure or heart medications such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan); or\nheart medications such as doxazosin (Cardura), isosorbide (Dilatrate, Imdur, Isordil, Monoket, Sorbitrate), nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat), prazosin (Minipress), or terazosin (Hytrin).\nThis list is not complete and other drugs may interact with Niaspan ER. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.\n Niaspan drug interactions (more detail)\n','Get emergency medical help if you have any of these signs of an allergic reaction to Niaspan ER: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have any of these serious side effects:\nfeeling like you might pass out;\nfast, pounding, or uneven heart beats;\nfeeling short of breath;\nswelling;\njaundice (yellowing of your skin or eyes); or\nmuscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine.\nIf you are diabetic, tell your doctor about any changes in your blood sugar levels.\nLess serious Niaspan ER side effects include:\nmild dizziness;\nwarmth, redness, or tingly feeling under your skin;\nitching, dry skin;\nsweating or chills;\nnausea, diarrhea, belching, gas;\nmuscle pain, leg cramps; or\nsleep problems (insomnia).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Niaspan side effects (more detail)\n','Niaspan ER extended release works by reducing LDL (\"bad\") cholesterol and triglycerides and increasing HDL (\"good\") cholesterol. Niaspan contains niacin, also called nicotinic acid, a B vitamin (vitamin B3). It occurs naturally in plants and animals and is present in many multiple vitamin supplements.\nNiaspan ER is used to lower cholesterol and triglycerides (types of fat) in the blood. It is also used to lower the risk of heart attack in people with high cholesterol who have already had a heart attack. It is sometimes used to treat coronary artery disease (also called atherosclerosis).\nNiaspan ER may also be used for purposes not listed in this medication guide.\n','You should not take Niaspan ER if you are allergic to niacin, or if you have severe liver disease, a stomach ulcer, or active bleeding.\nNiaspan ER can cause certain side effects, such as flushing (warmth, itching, redness, or tingly feeling under your skin). These effects can be made worse if you drink alcohol or hot beverages shortly after you take Niaspan ER. These effects should disappear over time as you keep taking the medication.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\nAvoid taking colestipol (Colestid) or cholestyramine (Locholest, Prevalite, Questran) at the same time you take Niaspan ER. If you take either of these other medications, take them at least 4 to 6 hours before or after you take this medicine.\nNiaspan ER is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.\nBefore taking this medicine\nYou should not take Niaspan ER if you are allergic to niacin, or if you have severe liver disease, a stomach ulcer, or active bleeding.\nTo make sure you can safely take Niaspan ER, tell your doctor if you have any of these other conditions:\nliver or kidney disease;\nheart disease or uncontrolled angina (chest pain);\na stomach ulcer;\ndiabetes;\ngout; or\na muscle disorder such as myasthenia gravis.\nFDA pregnancy category C. Niaspan ER may be harmful to an unborn baby when the medication is taken at doses to treat high cholesterol or other conditions. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Niacin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.\n Niaspan pregnancy and breastfeeding warnings (more detail)\n','Avoid drinking hot beverages shortly after taking Niaspan ER. Hot drinks can worsen the flushing effect (warmth, itching, redness, or tingly feeling under your skin).\nAvoid drinking alcohol while taking Niaspan ER. Alcohol may increase your risk of liver damage, and can also worsen the flushing effects of this medicine.\nAvoid taking colestipol (Colestid) or cholestyramine (Locholest, Prevalite, Questran) at the same time you take Niaspan ER. If you take either of these other medications, take them at least 4 to 6 hours before or after you take Niaspan ER.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\n'),(601,'nicotine','General\nTo increase smoking cessation rate,     use as part of a comprehensive program of multiple treatment strategies, including behavioral modification.                    \nIndividualize duration of therapy based on patient response and degree of nicotine dependence.     \nStop smoking prior to initiating nicotine replacement therapy;    self-medication not recommended in patients who continue to smoke, chew tobacco, or use snuff or other nicotine-containing preparations.  \nDiscontinue therapy in patients who continue to smoke 4 weeks after initiating treatment;    may use nicotine replacement therapy again in subsequent attempts to quit smoking.    \nAdministration\nAdminister nicotine percutaneously by topical application of a transdermal system. \nAdminister nicotine transmucosally by oral inhalation using a special nicotine oral inhaler or intranasally using a metered-dose spray pump.   \nAdminister nicotine polacrilex intrabuccally (transmucosally) as a lozenge or chewing gum. \nMay be administered as a single nicotine preparation (i.e., intrabuccally, intranasally, percutaneously, or by oral inhalation); however, if single therapy does not enable patients to quit smoking, use of transdermal nicotine may be combined with another form of nicotine replacement (i.e., either buccal nicotine polacrilex or nicotine nasal spray).\nBuccal Administration\nChewing Gum\nSelf-administer one piece of gum in response to the urge to smoke.\nChew gum very slowly until a distinctive peppery taste of nicotine, minty, cinnamon, or orange taste of the gum, or a slight tingling in the mouth is perceived (typically about 15 chews); stop chewing gum and park between cheek and gum; once tingling is almost gone (about 1 minute), repeat chewing procedure. Continue for about 30 minutes or until taste dissipates. Do not swallow gum.\nDo not eat or drink anything other than water for 15 minutes before and during chewing of gum. \nDo not chew multiple pieces of gum simultaneously; do not chew too rapidly or chew pieces in succession. May cause excessive release of nicotine and result in adverse effects (e.g., lightheadedness, nausea, vomiting, irritation of the throat and mouth, hiccups, indigestion).\nChew at least 9 pieces of gum daily to improve chances of quitting.\nDo not attempt to discontinue nicotine polacrilex gum therapy until craving is satisfied by 1 or 2 pieces of the gum daily, but do not continue therapy for >6 months, unless otherwise instructed by clinician.  \n4-mg strength gum recommended in highly dependent smokers because of evidence of increased efficacy.\nLozenges\nSuck on lozenge until dissolved; do not swallow, bite, or chew.   Allow to slowly dissolve in the mouth over 20–30 minutes, periodically moving the lozenge (e.g., with the tongue) from one side of the mouth to the other; minimize swallowing.  A warm or tingling sensation may be perceived.\nDo not eat or drink anything other than water for 15 minutes before and during sucking on the lozenge.  \nUse at least 9 lozenges daily for the first 6 weeks to improve chances of quitting.\nUsing >1 lozenge simultaneously or using one lozenge after another in uninterrupted sequence may result in adverse effects (e.g., hiccups, heartburn, nausea).\nSelf-administer lozenge in response to nicotine craving; decrease frequency of administration over time. \nTopical Administration\nAdminister percutaneously by topical application of a transdermal system once daily. \nApply at the same time each day, usually after awakening.       \nExpose the adhesive surface of the system by peeling and discarding the protective liner just prior to application and apply system immediately to avoid loss of nicotine through volatilization.    \nApply transdermal system to a clean, dry, hairless area of intact skin   on the trunk or upper outer arm        by firmly pressing the system with the adhesive side touching the skin.   Press system firmly in place with heel of hand for about 10 seconds, ensuring good contact, particularly around the edges.    Do not apply to sites that are oily, damaged, or irritated;   if necessary, hair may be clipped, but do not shave area.\nSystem may be worn for 16 or 24 hours.  If cravings begin upon awakening, wear patch for 24 hours.  If vivid dreams or sleep disruptions occur, wear patch for 16 hours; remove at bedtime and apply new patch upon awakening.   \nIf system inadvertently comes off during the period of use, apply a new system;       continue current application schedule or change so that the next system is applied 24 hours later.\nRotate application sites to minimize potential skin irritation; allow ≥1 week before reusing a given site.    (See Dermatologic Effects under Cautions.)\nAvoid unnecessary contact with transdermal systems.    Avoid touching eyes after handling; wash hands with water alone as soap may enhance percutaneous absorption.    \nIntranasal Administration\nAdminister intranasally using a metered-dose spray pump.\nPrime spray pump prior to initial use by spraying into a tissue until a fine spray is seen (6–8 times); discard tissue.\nIf spray pump is not used for 24 hours, reprime pump by spraying into a tissue 1–2 times.\nClear nasal passages prior to administration.\nTilt the head back slightly;  insert tip of bottle into one nostril as far as is comfortable. Breathe through the mouth and spray once into nostril; do not sniff, swallow, or inhale through the nose while administering. Repeat this procedure for the other nostril.\nIf nose runs, sniff gently to keep nasal spray in nose; wait 2–3 minutes before blowing nose.\nAvoid contact with skin, eyes, and mouth; if contact occurs, rinse with plain water immediately. If intranasal bottle breaks, wear protective gloves, wipe with paper towels, and wash surfaces thoroughly.\nOral Inhalation\nAdminister transmucosally as an inhaled vapor by oral inhalation using a special nicotine oral inhaler that mimics smoking cigarettes.    \nHold the oral inhaler with two hands; separate the top and bottom pieces by pushing and turning the pieces until markings line up. Insert one nicotine cartridge and push the cartridge until it pops into place. Line up markings on the top and bottom pieces of the inhaler and push pieces together tightly; lock inhaler by turning pieces until markings do not line up.\nPlace the mouthpiece of the inhaler between lips and puff on the inhaler using rapid shallow sucking (“buccal mode”);  alternatively, inhale slowly and deeply into back of throat (“pulmonary mode”).  Nicotine is vaporized and absorbed in mouth and throat. (See Absorption under Pharmacokinetics.) Shallow puffing method generally is preferred.   Deep inhalation technique requires considerable effort and does not result in substantially increased drug delivery or other benefits.\nIndividualize orally inhaled dosage to the level of nicotine replacement required; optimum results generally achieved by frequent continuous puffing of the inhaler over 20 minutes.\nNicotine is used up from cartridge after about four 5-minute sessions or one 20-minute session of active puffing.\nWhen cartridge is empty, remove top of mouthpiece; discard empty cartridge away from children and pets. Store with mouthpiece in locked position and cartridges in plastic case. Clean reusable mouthpiece regularly with soap and water.\nUse inhaler at temperatures >60°F; cold temperatures decrease the amount of nicotine inhaled.\nAlso administered transmucosally as an inhaled vapor by oral inhalation via electronic nicotine delivery systems (ENDS) such as e-cigarettes and vape pens; however, safety and efficacy in smoking cessation not evaluated by FDA.  \nDosage\nChewing gum and lozenges available as nicotine polacrilex; dosage expressed in terms of nicotine. \nNicotine oral inhaler cartridges labeled as containing 10 mg of nicotine deliver ≤4 mg total with repeated inhalation.   The amount of nicotine released depends on the volume and temperature of the air passing through the inhaler.     An intensive inhalation regimen (80 deep inhalations over 20 minutes) releases approximately 4 mg of nicotine.\nMetered nasal spray delivers 0.5 mg of the nicotine per metered spray and about 200 sprays (i.e., 100 doses) per 100-mg container.\nAdults\nSmoking Cessation\nBuccal (Chewing Gum)\nPatients who smoke <25 cigarettes daily: Chew a 2-mg piece of gum every 2 hours during weeks 1–6; chew a 2-mg piece every 2–4 hours during weeks 7–9; and chew a 2-mg piece every 4–8 hours during weeks 10–12 of therapy. Alternatively, chew a 2-mg piece of gum whenever the urge to smoke occurs; do not exceed 2 pieces (4 mg) per hour.\nPatients who smoke ≥25 cigarettes daily: Chew a 4-mg piece of gum every 2 hours during weeks 1–6; chew a 4-mg piece every 2–4 hours during weeks 7–9; and chew a 4-mg piece every 4–8 hours during weeks 10–12 of therapy. Alternatively, chew a 4-mg piece whenever the urge to smoke occurs; do not exceed 2 pieces (8 mg) per hour.\nTaper dosage by chewing each piece for only 10–15 minutes and gradually reducing the number of pieces chewed, or chew each piece for longer than 30 minutes but reduce the total pieces per day, or substitute regular chewing gum for some pieces.\nBuccal (Lozenges)\nPatients who smoke first cigarette >30 minutes after waking: One 2-mg lozenge every 1–2 hours during weeks 1–6; then one 2-mg lozenge every 2–4 hours during weeks 7–9; and one 2-mg lozenge every 4–8 hours during weeks 10–12.  \nPatients who smoke first cigarette ≤30 minutes after waking: One 4-mg lozenge every 1–2 hours during weeks 1–6; then one 4-mg lozenge every 2–4 hours during weeks 7–9; and one 4-mg lozenge every 4–8 hours during weeks 10–12.  \nDo not exceed 5 lozenges in 6 hours or 20 lozenges daily. \nDiscontinue therapy if mouth problems, persistent indigestion, severe sore throat, irregular heartbeat, palpitations, or symptoms suggestive of overdosage (nausea, vomiting, dizziness, diarrhea, weakness, and rapid heartbeat) develop.\nTransdermal\nPatients who smoke ≤10 cigarettes daily: Initially, 14 mg daily for 6 weeks, then 7 mg daily for 2 weeks, then discontinue.  \nPatients who smoke >10 cigarettes daily: Initially, 21 mg daily for 4–6 weeks; then 14 mg daily for 2 weeks; then 7 mg daily for 2 weeks; then discontinue therapy.  \nIntranasal\nInitially, 1–2 sprays (0.5–1 mg) in each nostril per hour (1–2 mg per hour total); may increase up to a maximum of 5 sprays (5 mg) in each nostril per hour (10 mg total) or a maximum total of 80 sprays (40 mg) daily. \nInitially, use at least 16 sprays (8 mg total) daily to increase chance of efficacy. Then, individualize dosage based on nicotine dependence and occurrence of symptoms of nicotine excess.\nContinue treatment in successfully abstinent patients for up to 8 weeks then discontinue over 4–6 weeks.\nTaper dosage by using only 1 spray at a time, using the spray less frequently, keeping a tally of daily usage, trying to meet a steadily reducing usage target, skipping a dose by not medicating every hour, or setting a planned “quit date” for stopping use of the spray. Some patients may not require tapering.\nOral Inhalation\nInitially, 6–16 cartridges daily for up to 12 weeks, then gradually decrease daily dosage over 6–12 weeks.  \nUse ≥6 cartridges daily for the first 3–6 weeks to increase chance of efficacy. Individualize dosage based on nicotine dependence and occurrence of symptoms of nicotine excess.\nTaper dosage by using less frequently, keeping a tally of daily usage, trying to meet a steadily reducing usage target, or setting a planned “quit date” for stopping use of the inhaler. Some patients may not require tapering.\nPrescribing Limits\nAdults\nSmoking Cessation\nBuccal (Chewing Gum)\nMaximum 2 pieces of 2-mg gum per hour (i.e., maximum 24 pieces [48 mg nicotine] daily). Maximum 12 weeks of therapy.\nMaximum 2 pieces of 4-mg gum per hour (i.e., maximum 24 pieces [96 mg nicotine] daily). Maximum 12 weeks of therapy.\nClinician supervised: Maximum 30 pieces of 2-mg gum daily (i.e., 60 mg nicotine) or 24 pieces of 4-mg gum daily (i.e., 96 mg nicotine).  \nBuccal (Lozenges)\nMaximum 5 lozenges in 6 hours or 20 lozenges daily. Maximum 12 weeks of therapy.\nTransdermal\nPatients who smoke ≤10 cigarettes daily: Maximum 8 weeks of therapy.\nPatients who smoke >10 cigarettes daily: Maximum 10 weeks of therapy.\nContinued therapy for periods longer than usually recommended may be appropriate for certain patients to promote extended abstinence. Continuation of therapy >12 weeks not recommended by manufacturer.   \nIntranasal\nMaximum 5 sprays (5 mg) in each nostril per hour (maximum 10 mg total) or a maximum total of 80 sprays (40 mg) daily.  \nManufacturer states that continuing therapy >12 weeks does not improve outcome. Safety of continuing therapy >6 months not established.\nOral Inhalation\nMaximum 16 cartridges daily for up to 12 weeks.\nManufacturer states that safety of continuing therapy >6 months not established.\nSpecial Populations\nNo special population dosage recommendations at this time. \n Detailed Nicotine dosage information\n','Cigarette smoke  and nicotine induce hepatic enzymes.  \nSmoking Cessation\nCessation of smoking may alter the response to concomitant administration of various drugs in patients who previously smoked.   \nPotential pharmacokinetic interaction (decreased metabolism and increased blood concentrations of certain drugs) with cessation of smoking.  \nConsider the effect of smoking cessation in patients receiving nicotine replacement therapy when patient is receiving other drugs concomitantly.       \nSympathomimetic and Sympatholytic Drugs\nPotential pharmacodynamic interaction (increased circulating plasma concentrations of cortisol and catecholamines); may require dosage adjustment of sympathomimetic (adrenergic) or sympatholytic (adrenergic blocking) drugs.\nPossible altered absorption of transdermal nicotine from drugs producing cutaneous vasoconstriction (e.g., sympathomimetic agents) or vasodilation (e.g., antihypertensive agents).\nFoods Affecting Salivary Acidity\nTransient decrease of salivary pH may inhibit buccal absorption of nicotine from gum, lozenge, or oral inhaler. \nSpecific Drugs and Foods\nDrug or Food\nInteraction\nComments\nAcetaminophen\nSmoking cessation may decrease metabolism and increase blood concentrations of acetaminophen\nDecrease dosage of acetaminophen as required\nAcidic beverages (e.g., coffee, juices, carbonated soft drinks)\nMay inhibit buccal absorption of nicotine from gum, lozenge, or orally inhaled drug  \nDo not eat or drink for 15 minutes before and during gum or lozenge therapy   \nAdrenergic agonists (e.g., isoproterenol, phenylephrine)\nSmoking cessation may decrease circulating plasma concentrations of catecholamines\nIncrease dosage of adrenergic agonists as required\nAdrenergic antagonists (e.g., prazosin, labetalol)\nSmoking cessation may decrease circulating plasma concentrations of catecholamines\nDecrease dosage of adrenergic antagonists as required\nβ-Adrenergic blocking agents (e.g., propranolol)\nSmoking cessation may decrease metabolism and increase blood concentrations of β-adrenergic blocking agents     \nSmoking cessation may restore the decreased cardiac output and hypotensive effect induced by propranolol  \nDecrease dosage of β-adrenergic blocking agent as required\nBupropion\nPossible increased risk of hypertension\nMay be used concomitantly with transdermal nicotine therapy\nCaffeine\nSmoking cessation may decrease metabolism and increase blood concentrations of caffeine     \nDecrease dosage of caffeine as required\nFurosemide\nSmoking cessation may increase diuretic effects of furosemide  \nGlutethimide\nSmoking cessation may decrease absorption of glutethimide \nInsulin\nSmoking cessation increases absorption of subcutaneous insulin\nMonitor blood glucose closely; adjust insulin dosage as needed\nNasal vasoconstrictors (e.g., xylometazoline)\nDelays time to peak plasma concentration of nicotine nasal spray\nOxazepam\nSmoking cessation may decrease metabolism and increase blood concentrations of oxazepam     \nDecrease dosage of oxazepam as required     \nPentazocine\nSmoking cessation may decrease metabolism and increase blood concentrations of pentazocine     \nDecrease dosage of pentazocine as required     \nPropoxyphene\nSmoking cessation may decrease metabolism of propoxyphene \nDecrease dosage of propoxyphene as required \nTheophylline\nSmoking cessation may decrease metabolism and increase blood concentrations of theophylline     \nMonitor plasma concentrations and adjust dosage of theophylline as required\nTricyclic antidepressants (e.g., imipramine)\nSmoking cessation may decrease metabolism and increase blood concentrations of tricyclic antidepressants     \nAdjust dosage of tricyclic antidepressant as required \n Nicotine drug interactions (more detail)\n',NULL,'Smoking Cessation\nUsed for nicotine replacement therapy as a temporary adjunct in the cessation of cigarette smoking either unsupervised (self-medication)     or in conjunction with a behavior modification program under clinician supervision.                        \nNicotine replacement therapy considered one of several first-line therapies by USPHS for treatment of tobacco dependence. For additional information, consult the most current USPHS clinical practice guideline available at [Web]\nNicotine replacement therapy provides alternative sources of nicotine that help reduce the withdrawal symptoms associated with nicotine dependence.           Chewing the resin complex-containing gum may act as a substitute oral activity in behavior modification.\nElectronic nicotine delivery systems (ENDS) such as electronic cigarettes (e-cigarettes) have been used to aid smoking cessation attempts; however, these products are not approved by FDA for this use and evidence is limited regarding their efficacy and safety.       The role of ENDS relative to conventional nicotine replacement therapies for smoking cessation remains to be established.   \nUlcerative Colitis\nTransdermal nicotine has been used in the management of ulcerative colitis†.       \n',NULL,NULL),(602,'nifedipine','Take nifedipine exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nYou may need to take an extended-release tablet on an empty stomach. Follow the directions on your medicine label about taking this medication with or without food.\nDo not crush, chew, or break a nifedipine extended-release tablet. Swallow it whole.\nYour blood pressure will need to be checked often and you may need other blood tests at your doctor\'s office.\nSome tablet forms of nifedipine are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect of nifedipine and will not make the medication less effective.\nIf you need surgery, tell the surgeon ahead of time that you are using nifedipine. You may need to stop using the medicine at least 36 hours before surgery.\nYou may have very low blood pressure while taking this medication. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual.\nIf you are also taking a beta-blocker (atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol, and others) you should not stop using the beta-blocker suddenly or you could have serious heart problems that will not be prevented by nifedipine. Follow your doctor\'s instructions about tapering your beta-blocker dose.\nYou should not stop using nifedipine suddenly. Stopping suddenly may make your condition worse.\nIf you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nStore at room temperature away from moisture, heat, and light.\n Detailed Nifedipine dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with nifedipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Nifedipine drug interactions (more detail)\n','Get emergency medical help if you have any signs of an allergic reaction to nifedipine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nworsening angina;\na light-headed feeling, like you might pass out;\npounding heartbeats or fluttering in your chest;\nchest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;\nswelling in your ankles or feet; or\nupper stomach pain, jaundice (yellowing of the skin or eyes).\nCommon nifedipine side effects may include:\nmild dizziness;\nflushing (warmth, redness, or tingly feeling);\nweakness, headache, mood changes;\nheartburn, nausea;\ntremors, muscle cramps; or\ncough, wheezing, sore throat, stuffy nose.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nifedipine side effects (more detail)\n','Nifedipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.\nNifedipine is used to treat hypertension (high blood pressure) and angina (chest pain).\nNifedipine may also be used for purposes not listed in this medication guide.\nWhat is the most important information I should know about nifedipine?\nYou should not use nifedipine if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks.\nBefore taking nifedipine, tell your doctor if you have kidney or liver disease, a blockage in your digestive tract (stomach or intestines), a history of stomach surgery, coronary artery disease, underactive thyroid, diabetes, or congestive heart failure.\nIf you need surgery, tell the surgeon ahead of time that you are using nifedipine. You may need to stop using the medicine for a short time.\nDo not stop taking nifedipine without first talking to your doctor, even if you feel fine. Stopping suddenly may make your condition worse. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\n',NULL,'Grapefruit and grapefruit juice may interact with nifedipine and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\n'),(603,'nitazoxanide','Usual Adult Dose for Cryptosporidiosis:\n500 mg orally every 12 hours for 3 daysUse: For the treatment of diarrhea due to Giardia lamblia or Cryptosporidium parvum\nUsual Adult Dose for Giardiasis:\n500 mg orally every 12 hours for 3 daysUse: For the treatment of diarrhea due to Giardia lamblia or Cryptosporidium parvum\nUsual Pediatric Dose for Cryptosporidiosis:\n1 to 3 years: 100 mg orally every 12 hours4 to 11 years: 200 mg orally every 12 hours12 years or older: 500 mg orally every 12 hoursDuration of Therapy: 3 daysUse: For the treatment of diarrhea due to G lamblia or C parvum\nUsual Pediatric Dose for Giardiasis:\n1 to 3 years: 100 mg orally every 12 hours4 to 11 years: 200 mg orally every 12 hours12 years or older: 500 mg orally every 12 hoursDuration of Therapy: 3 daysUse: For the treatment of diarrhea due to G lamblia or C parvum\n Detailed Nitazoxanide dosage information\n','Other drugs may interact with nitazoxanide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Nitazoxanide drug interactions (more detail)\nDoes Nitazoxanide interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCommon side effects may include:\nnausea, stomach pain;\nheadache; or\ndiscolored urine.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nitazoxanide side effects (more detail)\n','Nitazoxanide is an antiprotozoal medicine that treats infections caused by protozoa (single-cell parasites that live in moist places such as lakes, streams, and soil).\nNitazoxanide is used to treat diarrhea caused by Giardia or Cryptosporidium. These conditions are sometimes called \"Traveler\'s diarrhea.\" Nitazoxanide is used in adults and children who are at least 1 year old.\nNitazoxanide may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use nitazoxanide if you are allergic to it.\nTo make sure nitazoxanide is safe for you, tell your doctor if you have:\nliver or kidney disease;\nHIV or AIDS; or\na weak immune system.\nThe tablet form of  nitazoxanide should not be given to a child younger than 12 years old. Children ages 1 to 11 years should use only the oral suspension (liquid) form of nitazoxanide.\nNitazoxanide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant.\nIt is not known whether nitazoxanide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nHow should I take nitazoxanide?\nFollow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nTake nitazoxanide with food.\nNitazoxanide is usually taken once every 12 hours for 3 days. Follow your doctor\'s dosing instructions very carefully.\nShake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Throw away any unused liquid after 7 days.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(604,'nitrofurantoin','Usual Adult Dose for Cystitis:\nRegular release: 50 to 100 mg orally 4 times a day for 1 week or for at least 3 days after urine sterility is obtained\nDual release: 100 mg orally twice a day for 7 days\nUsual Adult Dose for Cystitis Prophylaxis:\nRegular release: 50 to 100 mg orally once a day at bedtime\nUsual Pediatric Dose for Cystitis:\nRegular release:\n1 month or older: 5 to 7 mg/kg/day (up to 400 mg/day) orally in 4 divided doses\nDual release:\nGreater than 12 years: 100 mg orally twice a day for 7 days\nUsual Pediatric Dose for Cystitis Prophylaxis:\nRegular release:\n1 month or older: 1 to 2 mg/kg/day (up to 100 mg/day) orally in 1 to 2 divided doses\n Detailed Nitrofurantoin dosage information\n','Other drugs may interact with nitrofurantoin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Nitrofurantoin drug interactions (more detail)\n','Get emergency medical help if you have any of these signs of an allergic reaction to nitrofurantoin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\ndiarrhea that is watery or bloody;\nsudden chest pain or discomfort, wheezing, dry cough or hack;\nnew or worsening cough, trouble breathing;\nfever, chills, body aches, tiredness, unexplained weight loss;\nnumbness, tingling, or pain in your hands or feet;\nliver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or\nlupus-like syndrome--joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color.\nSerious side effects may be more likely in older adults and those who are ill or debilitated.\nCommon nitrofurantoin side effects may include:\nheadache, dizziness;\ngas, upset stomach;\nmild diarrhea; or\nvaginal itching or discharge.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nitrofurantoin side effects (more detail)\n','Nitrofurantoin is an antibiotic that fights bacteria in the body.\nNitrofurantoin is used to treat urinary tract infections.\nNitrofurantoin may also be used for purposes not listed in this medication guide.\n','You should not take nitrofurantoin if you have severe kidney disease, urination problems, or a history of jaundice or liver problems caused by nitrofurantoin.\nDo not take this medicine if you are in the last 2 to 4 weeks of pregnancy.\nBefore taking this medicine\nYou should not take nitrofurantoin if you are allergic to it, or if you have:\nsevere kidney disease;\na history of jaundice or liver problems caused by taking nitrofurantoin;\nif you are urinating less than usual or not at all; or\nif you are in the last 2 to 4 weeks of pregnancy.\nDo not take nitrofurantoin if you are in the last 2 to 4 weeks of pregnancy.\nTo make sure nitrofurantoin is safe for you, tell your doctor if you have:\nkidney disease;\nanemia;\ndiabetes;\nan electrolyte imbalance or vitamin B deficiency;\nglucose-6-phosphate dehydrogenase (G6PD) deficiency; or\nany type of debilitating disease.\nFDA pregnancy category B. This medicine is not expected to be harmful to an unborn baby during early pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment.\nNitrofurantoin can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medicine.\nNitrofurantoin should not be given to a child younger than 1 month old.\n Nitrofurantoin pregnancy and breastfeeding warnings (more detail)\nHow should I take nitrofurantoin?\nFollow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nTake nitrofurantoin with food.\nShake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nYou may mix your liquid dose with water, milk, or fruit juice to make it easier to swallow. Drink the entire mixture right away.\nUse this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Nitrofurantoin will not treat a viral infection such as the common cold or flu.\nNitrofurantoin is usually given for up to 3 to 7 days.\nIf you use this medicine long-term, you may need frequent medical tests at your doctor\'s office.\nNitrofurantoin can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using nitrofurantoin.\nStore at room temperature away from moisture, heat, and light.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.\nAvoid using antacids without your doctor\'s advice. Use only the type of antacid your doctor recommends. Some antacids can make it harder for your body to absorb nitrofurantoin.\n'),(605,'nitroglycerin','Note: Safety: Contraindicated in patients taking a phosphodiesterase 5 (PDE5) inhibitor for any indication or a soluble guanylate cyclase inhibitor (eg, riociguat) due to potentially severe hypotension. In general, if a patient who has taken a PDE5 inhibitor for erectile dysfunction develops chest pain, delay nitrate therapy for ≥12 hours after taking avanafil, ≥24 hours after taking sildenafil or vardenafil, and ≥48 hours after taking tadalafil (Khera 2020; Stendra [avanafil] prescribing information). Consult drug interactions database for more information. In addition, avoid or use with caution in patients likely to develop hypotension or in whom hypotension could result in serious decompensation, including those with hypertrophic cardiomyopathy, severe aortic stenosis, or right ventricular infarction.\nAcute decompensated heart failure (adjunctive therapy): \nNote: Consider in patients with volume overload and without symptomatic hypotension to help relieve dyspnea when response to IV diuretics is not adequate (ACCF/AHA [Yancy 2013]).\nContinuous IV infusion: Initial: 5 to 10 mcg/minute; titrate as needed based on response and tolerability in increments of 5 to 10 mcg/minute every 3 to 5 minutes up to a maximum of 200 mcg/minute. Lower doses produce venous dilation; however, arterial vasodilation may occur at high doses (Colucci 2020; Coons 2011; Mebazaa 2016). Tachyphylaxis develops within 24 to 48 hours of continuous administration. Hemodynamic control after this initial period can be maintained by transitioning to long-term oral therapy for heart failure (Colucci 2020).\nAnal fissure (alternative agent):\nNote: Administer topically as a local vasodilator in conjunction with supportive measures. A 0.2% ointment is not commercially available and must be prepared by a licensed compounding facility (Bleday 2020).\nPeri-anal 0.2% or 0.4% ointment: After cleansing, apply around fissure(s) twice daily as directed for 4 weeks; if symptoms persist, continue treatment for another 4 weeks for a total duration of 8 weeks (Bacher 1997; Bleday 2020; Kennedy 1999; Lund 1997; Zuberi 2000).\nAngina: \nNote: Recommended for acute angina. For prevention of recurrent angina, may use in combination with other anti-anginal therapy (eg, a beta-blocker) (ACC/AHA [Amsterdam 2014]; ACCF/AHA [O\'Gara 2013]).\nAcute angina: \nNote: If pain is not relieved or worsens 3 to 5 minutes after 1 sublingual or translingual dose, seek immediate emergency medical attention (eg, call 911) (ACC/AHA [Amsterdam 2014]; ACCF/AHA [O\'Gara 2013]).\nSublingual powder (0.4 mg/packet): Initial: 1 or 2 packets at onset; repeat every 5 minutes if angina persists; may administer up to 3 packets in a 15-minute period (ACC/AHA [Amsterdam 2014]; ACCF/AHA [O\'Gara 2013]).\nSublingual tablet: Initial: 0.3 or 0.4 mg at onset; repeat every 5 minutes if angina persists; may administer up to 3 tablets in a 15-minute period (ACC/AHA [Amsterdam 2014]; ACCF/AHA [O\'Gara 2013]). For patients with refractory angina in the emergency department, up to 0.6 mg as a single dose may be considered (Reeder 2020).\nTranslingual 0.4 mg/spray: Initial: 1 or 2 sprays at onset; repeat every 5 minutes if angina persists; may administer up to 3 sprays in a 15-minute period (ACC/AHA [Amsterdam 2014]; ACCF/AHA [O\'Gara 2013]).\nContinuous IV infusion:\nNote: Consider IV therapy if angina is not relieved with other dosage forms. Avoid in patients with hypotension (eg, systolic BP <90 mm Hg or >30 mm Hg below baseline), marked bradycardia (eg, <50 beats per minute) or tachycardia (eg, >100 beats per minute), and/or suspected right ventricular infarction (ACCF/AHA [O\'Gara 2013]; Reeder 2020).\nInitial: 5 to 10 mcg/minute with continuous cardiac monitoring; titrate as needed to relieve angina symptoms in increments of 5 mcg/minute every 5 to 10 minutes up to 20 mcg/minute; if angina persists at a dose of 20 mcg/minute, may increase by 10 to 20 mcg/minute every 3 to 5 minutes to a maximum dose of 400 mcg/minute (ACCF/AHA [O\'Gara 2013]; Reeder 2020; manufacturer\'s labeling). Tachyphylaxis develops within 24 to 48 hours of continuous nitrate administration.\nPrevention of angina (adjunctive therapy):\nSublingual powder (0.4 mg/packet): Initial: 1 packet 5 to 10 minutes prior to activities that may provoke angina.\nSublingual tablet: Initial: 0.3 or 0.4 mg 5 to 10 minutes prior to activities that may provoke angina.\nTranslingual 0.4 mg/spray: Initial: 1 or 2 sprays 5 to 10 minutes prior to activities that may provoke angina.\nTopical 2% ointment: Initial: Apply ½ inch upon rising and apply another ½ inch 6 hours later; if necessary, the dose may be doubled to 1 inch and subsequently doubled again to 2 inches if response is inadequate. Recommended maximum frequency of administration is 2 doses/day. Include a nitrate-free interval of ~10 to 12 hours each day to minimize the risk of tolerance.\nTopical patch, transdermal: Initial: 0.2 to 0.4 mg/hour; increase dose as needed based on response and tolerability to a maximum of 0.8 mg/hour. Use a patch-on period of 12 to 14 hours/day and patch-off period (nitrate-free interval) of 10 to 12 hours/day to minimize the risk of tolerance. Alternatively, some experts recommend applying patch 30 to 45 minutes prior to activities that may provoke angina and removing patch after activity is complete (Chaudhary 2020).\nER capsule, oral: Initial: 2.5 to 6.5 mg 3 to 4 times daily; increase dose as needed based on response and tolerability to 26 mg 4 times daily. Include a nitrate-free interval of ~10 to 12 hours each day to minimize the risk of tolerance.\nExtravasation management, sympathomimetic vasopressors (alternative agent) (off-label use):\nNote: Nitroglycerin is an alternative if phentolamine is not available (Reynolds 2014).\nTopical 2% ointment: Apply a 1-inch strip to site of ischemia; may repeat every 8 hours if needed (Reynolds 2014).\nHypertension, perioperative (alternative agent):\nNote: For patients with chronic hypertension prior to surgery, restart oral therapies as soon as appropriate once hemodynamically stable. Address underlying causes (eg, pain, agitation, withdrawal, hypervolemia) prior to initiating antihypertensive therapy. Generally used for patients with hypervolemia who are not responsive to IV diuretic therapy, particularly if there is known or suspected ischemic heart disease or heart failure (Broussard 2020; London 2020).\nContinuous IV infusion: Initial: 5 to 10 mcg/minute; increase based on BP response and tolerability in increments of 5 mcg/minute every 3 to 5 minutes up to 20 mcg/minute; if no response at a dose of 20 mcg/minute, may increase by 10 to 20 mcg/minute every 3 to 5 minutes to a maximum dose of 200 mcg/minute. Lower doses primarily produce venous dilation; however, arterial vasodilation may occur at high doses (Broussard 2020; London 2020; manufacturer\'s labeling). Tachyphylaxis develops within 24 to 48 hours of continuous nitrate administration; if vasodilator requirements continue longer than 24 to 48 hours, transition to an alternative IV or oral vasodilator.\nHypertensive emergency (alternative agent) (off-label use):\nNote: Limitations of use include variable efficacy compared to other agents (eg, inconsistent and transient BP response), possible reflex tachycardia, and possible reduced cardiac output. May be used as adjunctive therapy for patients with acute coronary syndrome or acute pulmonary edema. In general, goal of therapy is to reduce mean arterial pressure ~10% to 20% over the first hour, then 5% to 15% further over the next 23 hours, unless there is a compelling indication (eg, acute aortic dissection, severe preeclampsia, eclampsia) for more rapid BP and heart rate control (ACC/AHA [Whelton 2018]; Elliot 2020a; Marik 2011).\nContinuous IV infusion: Initial: 5 mcg/minute; increase based on BP response and tolerability in increments of 5 mcg/minute every 3 to 5 minutes up to 20 mcg/minute; if no response at a dose of 20 mcg/minute, may increase by 10 to 20 mcg/minute every 3 to 5 minutes to a maximum dose of 200 mcg/minute. Lower doses produce venous dilation; however, arterial vasodilation may occur at high doses (ACC/AHA [Whelton 2018]; Elliot 2020b; Marik 2011). Tachyphylaxis develops within 24 to 48 hours of continuous nitrate administration; if vasodilator requirements continue longer than 24 to 48 hours, transition to an alternative IV or oral vasodilator.\nUterine relaxation (off-label use):\nNote: May be used for obstetric emergencies (eg, uterine inversion, difficult fetal extraction due to uterine contraction, internal podalic version of a second twin) or to facilitate extraction of a trapped placenta, external cephalic version, or replacement of deeply prolapsed fetal membranes before placement of a cerclage (Hofmeyr 2020; Macones 2020; Weeks 2020). Dosing provided is an example and may vary based on indication.\nIV: 50 mcg once; may repeat at 1-minute intervals as needed to sufficiently relax the uterus; maximum total dose: 250 mcg (Altabef 1992; Bayhi 1992; Chedraui 2003; Dayan 1996; Hofmeyr 2020; Macones 2020; Weeks 2020). If urgent uterine relaxation is required (eg, for fetal extraction), may use initial bolus of 100 to 200 mcg (Axemo 1998).\nDosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.\n Detailed Nitroglycerin dosage information\nDosing: Geriatric\nRefer to adult dosing.\nDosing: Pediatric\nNote: Nitronal IV solution has been discontinued in the US for more than 1 year.\nNote: Continuous IV infusion dosing units vary by age (mcg/kg/minute or mcg/minute); extra precautions should be taken. Tolerance to the hemodynamic and antianginal effects can develop within 24 to 48 hours of continuous use. Nitrate-free interval (10 to 12 hours/day) is recommended to avoid tolerance development; gradually decrease dose in patients receiving nitroglycerin for prolonged periods to avoid withdrawal reaction.\nHeart failure; cardiogenic shock: Limited data available:\nInfants and Children: Continuous IV infusion: Initial: 0.25 to 0.5 mcg/kg/minute; titrate by 1 mcg/kg/minute every 15 to 20 minutes as needed; faster titration may be necessary in some patients; in adolescents, titration every 3 to 5 minutes has been suggested; usual dose range: 1 to 5 mcg/kg/minute; usual maximum dose: 10 mcg/kg/minute (AHA [Chameides 2011]; Artman 1987; Ilbawi 1985; Park 2014); doses up to 20 mcg/kg/minute may be used (Friedman 1985)\nAdolescents: Continuous IV infusion: Initial: 5 to 10 mcg/minute; titrate every 3 to 5 minutes as needed to maximum rate of 200 mcg/minute (AHA [Chameides 2011]; Park 2014)\nExtravasation (sympathomimetic vasopressors), treatment (alternative to phentolamine): Very limited data available; dosing based on experience in neonatal patients; optimal dosing has not been established: Infants, Children, and Adolescents: Topical: 2% ointment: 4 mm/kg applied as a thin ribbon to the affected areas; after 8 hours if no improvement, the dose may be repeated at the affected site (Wong 1992). The maximum reported dose is application of a 1-inch strip to the affected site in a neonate (Denkler 1989); however, this is greater than the usual initial adult dose (1/2 inch) for angina; hypotension may occur; carefully monitor blood pressure (Reynolds 2014). Note: Minimal data available from clinical trials/case reports; however, use has been described in reviews of extravasation treatment (Reynolds 2014; Treadwell 2012).\nDosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.\nReconstitution\nVials: Dilute in D5W or NS; maximum concentration not to exceed 400 mcg/mL; prepare in glass bottles, EXCEL, or PAB containers (adsorption occurs to soft plastic (eg, PVC). Also available in premixed glass containers.\nAdministration\nIV: Prepare in glass bottles, EXCEL or PAB containers. Adsorption occurs to soft plastic (eg, PVC); use administration sets intended for nitroglycerin. Avoid in-line IV filters that adsorb nitroglycerin. Administer via infusion pump.\nIntra-anal ointment: Using a finger covering (eg, plastic wrap, surgical glove, finger cot), place finger beside 1 inch measuring guide on the box and squeeze ointment the length of the measuring line directly onto covered finger. Insert ointment into the anal canal using the covered finger up to first finger joint (do not insert further than the first finger joint) and apply ointment around the side of the anal canal. If intra-anal application is too painful, may apply the ointment to the outside of the anus. Wash hands following application.\nER capsule: Swallow whole. Do not chew, break, or crush. Administer with a full glass of water.\nBariatric surgery: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. Topical ointment and transdermal formulations are available. If safety and efficacy of nitroglycerin can be effectively monitored, no change in formulation or administration is required after bariatric surgery; however, selection of ointment, transdermal, or alternative therapy should be considered in high-risk patients.\nSublingual powder: Empty the contents of packet under the tongue, close mouth, and breathe normally. Allow powder to dissolve without swallowing. Do not rinse or spit for 5 minutes after dosing.\nSublingual tablet: Do not chew, crush, or swallow sublingual tablet. Place under tongue and allow to dissolve. Alternately, may be placed in the buccal pouch. May take small sip of water prior to placing tablet under the tongue to aid dissolution.\nTopical ointment: Wash hands prior to and after use. Application site should be clean, dry, and hair free. Apply to chest or back with the applicator or dose-measuring paper. Spread in a thin layer over a 2.25 x 3.5 inch area. Do not rub into skin. Tape applicator into place.\nExtravasation management, sympathomimetic vasopressors (alternative agent) (off-label use): Stop vesicant infusion immediately and disconnect IV line (leave needle/cannula in place); gently aspirate extravasated solution from the IV line (do NOT flush the line); remove needle/cannula; elevate extremity. Apply nitroglycerin ointment as a thin ribbon to site of ischemia (Reynolds 2014; Wong 1992). May also apply dry warm compresses (Hurst 2004; Reynolds 2014).\nTopical patch, transdermal: Application site should be clean, dry, and hair free. Remove patch after 12 to 14 hours. Rotate patch sites. Dispose of any used of unused patches by folding adhesive ends together, replace in pouch or sealed container and discard properly in trash, away from children and pets.\nTranslingual spray: Do not shake container. Prior to initial use, the pump must be primed by spraying 5 times (Nitrolingual) or 10 times (Nitromist) into the air. Priming sprays should be directed away from patient and others. Release spray onto or under tongue. Close mouth immediately after administration; do not inhale spray. Do not expectorate or rinse the mouth for 5 to 10 minutes following administration. Content of the container should be checked periodically; when the container is held upright, the end of the pump should be covered by the fluid in the bottle or the remaining sprays will not deliver the intended dose. If pump is unused for 6 weeks, a single priming spray (Nitrolingual) or 2 priming sprays (Nitromist) should be completed. If pump is unused for 3 months, re-prime with up to 5 sprays (Nitrolingual).\n','Alcohol (Ethyl): May enhance the vasodilatory effect of Vasodilators (Organic Nitrates). Monitor therapy\nAlfuzosin: May enhance the hypotensive effect of Nitroglycerin. Monitor therapy\nAlteplase: Nitroglycerin may decrease the serum concentration of Alteplase.  Monitor therapy\nAmifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine.  Management: When used at chemotherapy doses, hold blood pressure lowering medications for 24 hours before amifostine administration. If blood pressure lowering therapy cannot be held, do not administer amifostine. Use caution with radiotherapy doses of amifostine. Consider therapy modification\nAmisulpride (Oral): May enhance the hypotensive effect of Hypotension-Associated Agents. Monitor therapy\nAnticholinergic Agents: May decrease the absorption of Nitroglycerin. Specifically, anticholinergic agents may decrease the dissolution of sublingual nitroglycerin tablets, possibly impairing or slowing nitroglycerin absorption. Monitor therapy\nAntipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]).  Monitor therapy\nApomorphine: Nitroglycerin may enhance the hypotensive effect of Apomorphine.  Management: Patients taking apomorphine should lie down before and after taking sublingual nitroglycerin. Monitor blood pressure for hypotension and orthostatic hypotension when these agents are combined. Consider therapy modification\nBarbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nBenperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nBlood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents. Monitor therapy\nBrimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nBromperidol: Blood Pressure Lowering Agents may enhance the hypotensive effect of Bromperidol. Bromperidol may diminish the hypotensive effect of Blood Pressure Lowering Agents.  Avoid combination\nDapoxetine: May enhance the orthostatic hypotensive effect of Vasodilators (Organic Nitrates). Monitor therapy\nDapsone (Topical): May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Monitor therapy\nDiazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nDULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine.  Monitor therapy\nErgot Derivatives: May diminish the vasodilatory effect of Nitroglycerin. This is of particular concern in patients being treated for angina. Nitroglycerin may increase the serum concentration of Ergot Derivatives. Avoid combination\nHeparin: Nitroglycerin may diminish the anticoagulant effect of Heparin. Nitroglycerin may decrease the serum concentration of Heparin.  Monitor therapy\nHerbs (Hypotensive Properties): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nHypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents.  Monitor therapy\nLevodopa-Containing Products: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa-Containing Products.  Monitor therapy\nLocal Anesthetics: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased.  Monitor therapy\nLormetazepam: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nMolsidomine: May enhance the hypotensive effect of Vasodilators (Organic Nitrates). Monitor therapy\nMolsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nNaftopidil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nNicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nNicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nNitric Oxide: May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Monitor therapy\nNitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside.  Monitor therapy\nObinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Consider therapy modification\nPentoxifylline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nPholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine.  Monitor therapy\nPhosphodiesterase 5 Inhibitors: May enhance the vasodilatory effect of Vasodilators (Organic Nitrates). Avoid combination\nPrilocaine: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Prilocaine. Combinations of these agents may increase the likelihood of significant methemoglobinemia.  Management: Monitor patients for signs of methemoglobinemia (e.g., hypoxia, cyanosis) when prilocaine is used in combination with other agents associated with development of methemoglobinemia.  Avoid lidocaine/prilocaine in infants receiving such agents. Monitor therapy\nProstacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nQuinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy\nRilmenidine: Vasodilators (Organic Nitrates) may enhance the hypotensive effect of Rilmenidine.  Monitor therapy\nRiociguat: Vasodilators (Organic Nitrates) may enhance the hypotensive effect of Riociguat.  Avoid combination\nRosiglitazone: Vasodilators (Organic Nitrates) may enhance the adverse/toxic effect of Rosiglitazone. Specifically, a greater risk of ischemia and other adverse effects has been associated with this combination in some pooled analyses.  Monitor therapy\nSodium Nitrite: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Sodium Nitrite. Combinations of these agents may increase the likelihood of significant methemoglobinemia.  Monitor therapy\n Nitroglycerin drug interactions (more detail)\nTest Interactions\nIV formulation: Due to propylene glycol content, triglyceride assays dependent on glycerol oxidase may be falsely elevated.\nAdverse Reactions\nThe following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.\n>10%: Nervous system: Headache (patch, ointment: 50% to 64%; sublingual powder, lingual spray: >2%)\n1% to 10%:\nCardiovascular: Hypotension (≤4%), peripheral edema (lingual spray: ≤2%), syncope (≤4%)\nGastrointestinal: Abdominal pain (lingual spray: ≤2%)\nNervous system: Dizziness (>2% to 6%), paresthesia (>2%)\nNeuromuscular & skeletal: Asthenia (all sublingual forms: ≤2%)\nRespiratory: Dyspnea (≤2%), pharyngitis (lingual spray: ≤2%), rhinitis (lingual spray: ≤2%)\nFrequency not defined:\nCardiovascular: Flushing, orthostatic hypotension\nDermatologic: Diaphoresis\n<1%, postmarketing, and/or case reports: Application site irritation (patch), circulatory shock, contact dermatitis (ointment, patch), drowsiness, exfoliative dermatitis, fixed drug eruption (ointment, patch), hypersensitivity reaction, hypoxemia (transient), lactic acidosis (Smith 2019), methemoglobinemia, nausea, nonimmune anaphylaxis, pallor, palpitations, rebound hypertension, restlessness, skin rash, tachycardia, vertigo, vomiting\n',NULL,'Oral administration: Treatment or prevention of angina pectoris.\nIV administration: Treatment of angina pectoris; acute decompensated heart failure; perioperative hypertension; induction of intraoperative hypotension.\nIntra-anal administration (Rectiv ointment): Treatment of moderate to severe pain associated with chronic anal fissure.\nOff Label Uses\nExtravasation management, sympathomimetic vasopressors\nClinical experience suggests utility of topical nitroglycerin in the management of sympathomimetic vasopressor extravasations [Hurst 2004], [Reynolds 2014].\nHypertensive emergency\nBased on the American College of Cardiology/American Heart Association guideline for the prevention, detection, evaluation, and management of high blood pressure in adults, nitroglycerin is an option for hypertensive emergency, especially if there is concomitant acute coronary syndrome or pulmonary edema [ACC/AHA [Whelton 2018]].\nUterine relaxation\nBased on its ability to relax smooth muscle, nitroglycerin has been used in observational studies and case reports to induce uterine relaxation in obstetrical procedures such as removal of a retained placenta or when uterine inversion occurs following childbirth [Altabef 1992], [Axemo 1998], [Bayhi 1992], [Chedraui 2003], [Dayan 1996], [Dufour 1997], [Lowenwirt 1997].\nBased on the American College of Obstetricians and Gynecologists guidelines for the treatment of postpartum hemorrhage, nitroglycerin is an option when uterine relaxation is needed in the management of uterine inversion [ACOG 183 2017]. Based on the American Society of Anesthesiologists practice guidelines for obstetric anesthesia, nitroglycerin may be used as an alternative agent for uterine relaxation during removal of retained placental tissue [ASA 2016].\n','Concerns related to adverse effects:\n• Headache: Dose-related headaches may occur, especially during initial dosing.\n• Hypotension/bradycardia: Severe hypotension and shock may occur (even with small doses); paradoxical bradycardia and increased angina pectoris may accompany hypotension. Orthostatic hypotension may also occur; ethanol may accentuate this. Use with caution in volume depletion, preexisting hypotension, constrictive pericarditis, aortic or mitral stenosis, and extreme caution with inferior wall myocardial infarction (MI) and suspected right ventricular involvement. According to the American College of Cardiology Foundation/American Heart Association, avoid use in patients with severe hypotension (SBP <90 mm Hg or >30 mm Hg below baseline), marked bradycardia or tachycardia, and right ventricular MI (ACCF/AHA [O\'Gara 2013]).\n• Increased intracranial pressure: Nitroglycerin may precipitate or aggravate increased intracranial pressure and subsequently may worsen clinical outcomes in patients with neurologic injury (eg, intracranial hemorrhage, traumatic brain injury) (Rangel-Castilla 2008). Use is contraindicated in patients with increased intracranial pressure.\nDisease-related concerns:\n• Hypertrophic cardiomyopathy: Avoid use in patients with hypertrophic cardiomyopathy with outflow tract obstruction; nitrates may reduce preload, exacerbating obstruction and cause hypotension or syncope and/or worsening of heart failure (HF) (ACCF/AHA [Gersh 2011]).\nDosage form specific issues:\n• Intra-anal ointment: Use caution when treating rectal anal fissures with nitroglycerin in patients with suspected or known significant cardiovascular disorders (eg, cardiomyopathies, HF, acute MI); intra-anal nitroglycerin administration may decrease systolic BP and decrease arterial vascular resistance.\n• Long-acting agents: Avoid use of long-acting agents in acute MI or acute HF; cannot easily reverse effects if adverse events develop.\n• Propylene glycol: Some dosage forms may contain propylene glycol; large amounts are potentially toxic and have been associated hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP 1997; Zar 2007).\n• Transdermal patches: May contain conducting metal (eg, aluminum); remove patch prior to MRI.\nOther warnings/precautions:\n• Tolerance: May occur; cross tolerance to other nitro compounds have been reported. Appropriate dosing is needed to minimize tolerance development.\nMonitoring Parameters\nBlood pressure, heart rate; consult individual institutional policies and procedures\n',NULL),(606,'nitrostat','Usual Adult Dose for Angina Pectoris:\n0.3 to 0.6 mg sublingually or in the buccal pouch every 5 minutes as needed, up to 3 doses in 15 minutes; if pain persists after maximum dose, prompt medical attention is recommended.\nUsual Adult Dose for Angina Pectoris Prophylaxis:\n0.3 to 0.6 mg sublingually or in the buccal pouch 5 to 10 minutes prior to engaging in activities that might precipitate an acute attack\nComments:\n-Administer while sitting due to rapid onset.\n-Advise patient not to chew or swallow this medication.\n Detailed Nitrostat dosage information\nWhat happens if I miss a dose?\nIf you use Nitrostat on a regular schedule, skip any missed dose if it\'s almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nitroglycerin can be fatal.\nOverdose symptoms may include a throbbing headache, confusion, pounding heartbeats, vision problems, vomiting, bloody diarrhea, sweating, clammy skin, blue lips, weak or shallow breathing, loss of movement, seizure, or fainting.\n','Tell your doctor about all your current medicines, especially:\naspirin, heparin;\na diuretic (water pill);\nany medicine to treat erectile dysfunction;\nmedicine to treat depression or psychiatric illness;\nmedicine used to treat blood clots;\nheart or blood pressure medicine; or\nmigraine headache medicine, such as ergot medicine (dihydroergotamine, ergotamine, ergonovine, methylergonovine).\nThis list is not complete and many other drugs may interact with nitroglycerin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Nitrostat drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nitrostat: hives, sweating, pale skin; nausea, vomiting; feeling weak or light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere or throbbing headaches that do not become less severe with continued use of Nitrostat;\npounding heartbeats or fluttering in your chest;\nslow heart rate;\na light-headed feeling, like you might pass out;\nblurred vision or dry mouth; or\nheart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.\nNitroglycerin can cause severe headaches that should become less severe as you continue to use the medicine.\nCommon Nitrostat side effects may include:\nflushing (sudden warmth, redness, or tingly feeling);\nfeeling light-headed, fainting;\nheadache, dizziness; or\nnumbness, tingling, burning pain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nitrostat side effects (more detail)\n','Nitrostat (nitroglycerin) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.\nNitrostat sublingual tablets are used to treat a type of chest pain called angina.\nAngina is a pain or discomfort that keeps coming back when part of your heart does not get enough blood. Angina feels like a pressing or squeezing pain, usually in your chest under the breastbone. Sometimes you can feel it in your shoulders, arms, neck, jaws, or back. Nitrostat can relieve this pain.\nNitrostat is a white, round, flat-faced tablet available in 3 strengths. 0.3 mg, 0.4 mg, and 0.6 mg.\n','You should not use Nitrostat if you are also using medicine to treat pulmonary arterial hypertension (PAH). Do not take erectile dysfunction medicine (Viagra, Cialis, Levitra and others) while you are using Nitrostat.\nYou should not use sublingual Nitrostat if you have severe anemia, increased pressure inside your skull, circulation problems, chest pain that spreads to your jaw or shoulder, or signs of shock (pale skin, suddenly feeling light-headed).\nSeek emergency medical attention if you have early symptoms of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating, general ill feeling).\nGet emergency medical help if you still have chest pain after using a total of 3 doses in 15 minutes, or if you have chest pain that seems unusual.\nBefore using this medicine\nYou may not be able to use Nitrostat if you have:\nsevere anemia (low red blood cells);\nincreased pressure inside the skull;\ncirculation problems or shock (pale or clammy skin, cold sweat, numbness or tingling, fast or irregular heartbeats, or feeling like you might pass out); or\nif you also take riociguat or vericiguat.\nDo not use erectile dysfunction medicine (such as Viagra, Cialis, or Levitra) or you could have a sudden and serious decrease in blood pressure.\nTo make sure Nitrostat is safe for you, tell your doctor if you have ever had:\nan allergic reaction to nitroglycerin;\na heart attack or other heart problems; or\nlow blood pressure.\nTell your doctor if you are pregnant or breastfeeding.\nNitrostat is not approved for use by anyone younger than 18 years old.\nHow should I use Nitrostat?\nUse Nitrostat exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Try to rest or stay seated when you use Nitrostat (may cause dizziness or fainting).\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nUse this medicine at the first sign of chest pain. Use another dose every 5 minutes as needed, up to a total of 3 doses.\nGet emergency medical help if you still have chest pain after using a total of 3 doses in 15 minutes, or if your chest pain seems unusual.\nYou may use Nitrostat within 5 to 10 minutes before an activity that might cause chest pain.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Nitrostat.\nIf you use Nitrostat on a regular schedule to prevent angina, do not stop using it suddenly or you could have a severe attack of angina. Keep this medicine on hand at all times. Get your prescription refilled before you run out of medicine completely.\nStore Nitrostat at room temperature away from moisture and heat.\nKeep the spray away from open flame or high heat, such as in a car on a hot day. The canister may explode if it gets too hot.\n','Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nDrinking alcohol can increase certain side effects such as dizziness, drowsiness, feeling light-headed, or fainting.\n'),(607,'nivolumab','Nivolumab is given as an infusion into a vein by a healthcare provider. This medicine must be given slowly, and the infusion can take 30 to 90 minutes to complete.\nNivolumab is usually given once every 2 to 4 weeks. Your other cancer medicines may be given on different schedules. Your doctor will determine how long to treat you with all medicines.\nYou will need frequent medical tests to help your doctor determine if it is safe for you to keep receiving this medicine.\nNivolumab can cause side effects in many different parts of your body. You may be given medication to prevent certain side effects, and your cancer treatments may be delayed if you need treatment for a side effect.\n Detailed Nivolumab dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss a chemotherapy appointment.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with nivolumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Nivolumab drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to nivolumab (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nSome side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, short of breath, itchy, or tingly, or if you have a fever, chills, back pain or neck pain.\nCall your doctor at once if you have:\nsevere or ongoing diarrhea, severe stomach pain, bloody or tarry stools;\neye pain, vision changes, sensitivity to light;\nsevere muscle pain or weakness;\nconfusion, memory problems, neck stiffness, drowsiness, balance problems;\nnumbness or tingling in your arms or legs;\nkidney problems - little or no urination, swelling in your feet or ankles, blood in your urine;\nliver problems - severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);\nlung problems - new or worsening cough, chest pain, feeling short of breath;\nskin problems - rash, itching, redness, swelling, pain, sores, blisters, sores in your mouth or nose or on your genitals;\nsigns of a hormonal disorder - frequent or unusual headaches, vision problems, fast heartbeats, dizziness, fainting, tiredness, mood or behavior changes, hunger, increased thirst or urination, constipation, hair loss, hoarse or deepened voice, sweating, feeling cold, weight gain or loss; or\n(if you have had a stem cell transplant) feeling sick or uneasy, with pain or swelling near your transplanted organ.\nYour cancer treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon nivolumab side effects may include:\nnausea, vomiting, stomach pain, loss of appetite, diarrhea, constipation;\nmouth sores, altered sense of taste;\nitching, rash, redness or blisters on your hands or feet;\nhormonal problems;\nliver problems;\nnumbness, tingling, or burning pain in your hands or feet;\nfever, body aches;\nfeeling weak, tired, or short of breath;\ncold symptoms such as runny or stuffy nose, cough, sore throat;\nheadache, dizziness, increased blood pressure; or\nweight loss.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nivolumab side effects (more detail)\n','Nivolumab is a cancer medicine that is used alone or in combination with other medicines to treat adults with:\nadvanced skin cancer (melanoma);\nadvanced non-small cell lung cancer;\npleural mesothelioma (cancer that affects the lining of the lungs and chest wall);\nkidney cancer;\nclassical Hodgkin lymphoma;\ncancer of the stomach and esophagus;\nsquamous cell cancer of the esophagus or head and neck;\nbladder cancer;\nliver cancer; or\ncolorectal cancer.\nNivolumab is often given when the cancer has spread to other parts of the body (metastatic), or cannot be surgically removed, or has come back after prior treatment.\nNivolumab is sometimes given only if laboratory testing shows specific genetic markers or DNA mutations associated with your cancer.\n','Nivolumab can cause side effects in many different parts of your body. Some side effects may need to be treated with other medicine, and your cancer treatments may be delayed.\nCall your doctor at once if you have: a cough, shortness of breath, vision changes, muscle pain or weakness, stomach pain, diarrhea, blood in your stools, little or no urinating, bruising or bleeding, dark urine, yellowing of your skin or eyes, frequent headaches, dizziness, confusion, increased thirst or urination, skin problems, numbness or tingling, feeling cold, or weight gain or loss.\nA very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. Nivolumab can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.\nEye problems have happened with nivolumab. Some types of eye problems may need to be treated right away to lower the chance of long-lasting eyesight loss. Call your doctor right away if you have any changes in eyesight, eye pain, or very bad eye irritation.\nA certain brain problem has happened with nivolumab. Rarely, this has been deadly. Call your doctor right away if you are confused, sleepy, very tired or weak, or have a fever, hallucinations, memory problems, seizures, stiff neck, or very bad headache.\nBefore taking this medicine\nTo make sure nivolumab is safe for you, tell your doctor if you have:\nchemotherapy or radiation treatment;\na nervous system disorder such as myasthenia gravis or Guillain-Barré syndrome;\nliver disease;\nan autoimmune disorder (lupus, Crohn\'s disease, ulcerative colitis); or\nan organ transplant, or a stem cell transplant from a donor.\nNivolumab may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while receiving nivolumab and for at least 5 months after your last dose. Tell your doctor if you become pregnant.\nDo not breastfeed while using nivolumab, and for at least 5 months after your last dose.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(608,'norco','Usual Adult Dose of Norco for Pain:\nTablets:\nRecommended dose:\nAcetaminophen-hydrocodone 300 mg-5 mg: 1 to 2 tablets orally every 4 to 6 hours as needed\nMaximum dose:\nAcetaminophen-hydrocodone 300 mg-5 mg: 8 tablets daily\nComments:\nDosage should be adjusted according to severity of the pain and the response of the patient. Tolerance to hydrocodone can develop with continued use and the incidence of side effects is dose related.\nApproved indication: For the relief of moderate to moderately severe pain\n Detailed Norco dosage information\nWhat happens if I miss a dose?\nSince Norco is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. A hydrocodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.\nYour doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don\'t wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.\nAnyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nNorco can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother narcotic medications - opioid pain medicine or prescription cough medicine;\na sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;\ndrugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or\ndrugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete. Other drugs may interact with acetaminophen and hydrocodone, including prescription and over-the- counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Norco drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Norco: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nIn rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.\nCall your doctor at once if you have:\nnoisy breathing, sighing, shallow breathing, breathing that stops during sleep;\na light-headed feeling, like you might pass out;\nconfusion, unusual thoughts or behavior;\nseizure (convulsions);\neasy bruising or bleeding;\ninfertility, missed menstrual periods;\nimpotence, sexual problems, loss of interest in sex;\nliver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or\nhigh levels of serotonin in the body - agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.\nSerious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.\nCommon Norco side effects include:\ndrowsiness, headache;\nupset stomach, constipation;\nblurred vision; or\ndry mouth.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Norco side effects (more detail)\n','Norco contains a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.\nNorco is used to relieve moderate to moderately severe pain.\nNorco may also be used for purposes not listed in this medication guide.\n','Hydrocodone can slow or stop your breathing. Never use Norco in larger amounts, or for longer than prescribed. Opioid pain medicine may be habit-forming, even at regular doses. Never share Norco with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.\nMISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.\nDo not use Norco if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.\nAn overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).\nStop taking Norco and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.\nBefore taking this medicine\nYou should not use Norco if you are allergic to acetaminophen (Tylenol) or hydrocodone, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.\nDo not use Norco if you have taken a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.\nSome medicines can interact with hydrocodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson\'s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.\nYou should not use this medicine if you have:\nsevere asthma or breathing problems; or\na blockage in your stomach or intestines.\nTo make sure Norco is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea (breathing stops during sleep);\nliver disease;\na drug or alcohol addiction;\nkidney disease;\na head injury or seizures;\nurination problems; or\nproblems with your thyroid, pancreas, or gallbladder.\nNorco is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.\nIf you use narcotic medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.\nAsk a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.\nHow should I take Norco?\nTake Norco exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.\nHydrocodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away Norco is against the law.\nIf you need surgery or medical tests, tell the doctor ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.\nDo not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Norco.\nStore Norco at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nAlways check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor.\n','This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how Norco will affect you. Dizziness or severe drowsiness can cause falls or other accidents.\nAsk a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.\nAvoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.\n'),(609,'norepinephrine','Norepinephrine is given as an infusion into a vein. A healthcare provider will give you this injection.\nNorepinephrine is usually given for as long as needed until your body responds to the medication. Some people must receive norepinephrine for several days.\nYour blood pressure, breathing, and other vital signs will be watched closely while you are receiving norepinephrine.\nTell your caregivers if you feel any pain, irritation, cold feeling, or other discomfort of your skin or veins where the medicine is injected. Norepinephrine can damage the skin or tissues around the injection site if the medicine accidentally leaks out of the vein.\n Detailed Norepinephrine dosage information\nWhat happens if I miss a dose?\nSince norepinephrine is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include slow heartbeats, severe headache, sweating, vomiting, increased sensitivity to light, pale skin, and stabbing chest pain.\n','If possible before you receive norepinephrine, tell your doctor about all your other medicines, especially:\nan antidepressant;\nblood pressure medication; or\nan MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.\nThis list is not complete. Other drugs may affect norepinephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Norepinephrine drug interactions (more detail)\nDoes Norepinephrine interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nTell your caregivers at once if you have:\npain, burning, irritation, discoloration, or skin changes where the injection was given;\nsudden numbness, weakness, or cold feeling anywhere in your body;\nslow or uneven heart rate;\nblue lips or fingernails, mottled skin;\nlittle or no urination;\ntrouble breathing;\nproblems with vision, speech, or balance; or\nsevere headache, blurred vision, pounding in your neck or ears.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Norepinephrine side effects (more detail)\n','Norepinephrine is similar to adrenaline. It is used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. Norepinephrine is often used during CPR (cardio-pulmonary resuscitation).\nNorepinephrine may also be used for purposes not listed in this medication guide.\n','Tell your caregivers at once if you have a serious side effect such as a cold feeling anywhere in your body, blue lips or fingernails, trouble breathing, little or no urination, irritation or skin changes where the medicine was injected, slow heart rate, sudden numbness or weakness, severe headache, or problems with vision, speech, or balance.\nBefore taking this medicine\nIf possible before you receive norepinephrine, tell your caregivers if you have:\nhigh blood pressure (hypertension);\ndiabetes;\ncoronary artery disease;\ncirculation problems;\nvaricose veins;\noveractive thyroid; or\nasthma or a sulfite allergy.\nTell your doctor if you are pregnant or breastfeeding.\nIn an emergency, you may not be able to tell caregivers about your health conditions or if you are pregnant or breastfeeding. Make sure any doctor caring for you afterward knows you received  norepinephrine.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(610,'norethindrone','Usual Adult Dose for Abnormal Uterine Bleeding:\n2.5 to 10 mg orally once a dayDuration of therapy: 5 to 10 daysComments:-This drug should be used when the endometrium is adequately primed with endogenous/exogenous estrogen.-Withdrawal bleeding typically occurs within 3 to 7 days of treatment discontinuation.Use: Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance without organic pathology (e.g., submucous fibroids, uterine cancer)\nUsual Adult Dose for Amenorrhea:\n2.5 to 10 mg orally once a dayDuration of therapy: 5 to 10 daysComments:-This drug should be used when the endometrium is adequately primed with endogenous/exogenous estrogen.-Withdrawal bleeding typically occurs within 3 to 7 days of treatment discontinuation.Use: Treatment of secondary amenorrhea and abnormal uterine bleeding due to hormonal imbalance without organic pathology (e.g., submucous fibroids, uterine cancer)\nUsual Adult Dose for Contraception:\n0.35 mg orally once a dayComment:-This drug should be taken at the same time each day.Use: Prevention of pregnancy\nUsual Adult Dose for Endometriosis:\nInitial dose: 5 mg orally once a day for 2 weeks-Maximum dose: 15 mg/dayComments:-The dose should be increased by 2.5 mg/day every 2 weeks until 15 mg is reached.-Treatment may continue for 6 to 9 months OR until annoying breakthrough bleeding demands temporary termination.Uses: Treatment of endometriosis\nUsual Pediatric Dose for Contraception:\nPostpubertal adolescents (under 16 years): 0.35 mg orally once a dayComments:-This drug should be used after menarche occurs.-The dose should be taken at the same time each day.Use: Prevention of pregnancy\n Detailed Norethindrone dosage information\n','Some drugs can make norethindrone less effective, which may result in unintended pregnancy if you use  norethindrone for contraception. Tell your doctor about all your other medicines, especially:\nSt. John\'s wort;\nmedicine to treat an infection (antibiotics or antifungal medicine);\nmedicine to treat tuberculosis;\nmedicine to treat HIV or AIDS; or\nseizure medication.\nThis list is not complete. Other drugs may affect norethindrone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Norethindrone drug interactions (more detail)\nDoes Norethindrone interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsudden vision loss, bulging eyes, or severe headache;\nswelling, rapid weight gain;\nunusual vaginal bleeding;\nmissed menstrual periods;\npelvic pain (especially on one side);\na breast lump;\na light-headed feeling, like you might pass out;\nincreased thirst, increased urination;\nliver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or\nsigns of a blood clot--sudden numbness or weakness, problems with vision or speech, chest pain, shortness of breath, swelling or redness in an arm or leg.\nCommon side effects may include:\nirregular vaginal bleeding or spotting;\nheadache;\nbreast pain or swelling;\nstomach pain, bloating, nausea, vomiting;\nhair loss;\ndepressed mood, trouble sleeping;\nweight gain; or\nvaginal itching or discharge.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Norethindrone side effects (more detail)\n','Norethindrone is a form of progesterone, a female hormone important for regulating ovulation and menstruation.\nNorethindrone is used for birth control (contraception) to prevent pregnancy.\nNorethindrone is also used to treat menstrual disorders, endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance.\nNot all brands of  norethindrone are for the same uses. Some brands are for use only as contraception. Others are for use in treating endometriosis or vaginal bleeding disorders. Avoid medication errors by using only the brand, form, and strength your doctor prescribes.\nNorethindrone may also be used for other purposes not listed in this medication guide.\n','You should not use this medicine if you you have: undiagnosed vaginal bleeding, breast cancer, liver disease, or a liver tumor. You may not be able to take norethindrone if you have ever had a heart attack, a stroke, or blood clot.\nDo not use if you are pregnant or trying to become pregnant.\nIn some cases, you should not take norethindrone if you are nursing.\nBefore taking this medicine\nYou should not use norethindrone if you are allergic to it, or if you have:\nunusual vaginal bleeding that has not been checked by a doctor;\nliver disease or a liver tumor;\nbreast cancer; or\na history of blood clots in your brain, eyes, lungs, or legs.\nDo not use norethindrone if you are pregnant or trying to become pregnant. Stop taking the medicine and tell your doctor right away if you become pregnant.\nAsk your doctor about using  norethindrone while you are breast-feeding. In some cases, you should not take norethindrone if you are nursing.\nTell your doctor if you have ever had:\nheart disease, high blood pressure;\nliver disease;\ndepression;\nmigraine headaches;\ndiabetes;\nhigh cholesterol or triglycerides;\nuterine fibroid tumors;\nepilepsy;\nkidney disease;\nasthma; or\nif you smoke.\nDo not give this medicine to a child without medical advice.\nHow should I take norethindrone?\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nCarefully follow your doctor\'s dosing instructions about when to start taking norethindrone for contraception if you are switching from a combination birth control pill (estrogen and progestin).\nIf you take norethindrone for contraception: Take one pill every day, no more than 24 hours apart. You may get pregnant if you do not take one pill daily.\nYou may need to use back-up birth control (such as condoms with spermicide) if you are sick with vomiting or diarrhea, or if you are 3 or more hours late in taking your daily dose.\nIf you take norethindrone for menstrual disorders or abnormal vaginal bleeding: You will most likely take the medicine for only 5 to 10 days. Vaginal bleeding will occur 3 to 7 days after your last dose.\nIf you take norethindrone for endometriosis: Norethindrone is usually taken daily long-term for several months. Your doctor may occasionally change your dose.\nYour doctor should check your progress on a regular basis. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.\nReport any unusual vaginal bleeding right away.\nNorethindrone can affect the results of certain medical tests. Tell any doctor who treats you that you are using norethindrone.\nStore this medication at room temperature away from moisture, heat, and light.\nWhat happens if I miss a dose?\nCall your doctor for instructions, or follow the patient instructions provided with your medicine.\nMissing a birth control pill increases your risk of becoming pregnant. If you are more than 3 hours late for your dose, take the medicine as soon as you remember and use back-up birth control for at least 48 hours. Take your next pill at the regularly scheduled time and continue on your regular dosing schedule.\nIf you miss a period for two months in a row, call your doctor because you might be pregnant.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nAn overdose of norethindrone is not expected to be dangerous.\n','Do not use estrogen medication unless your doctor tells you to.\nAvoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while taking norethindrone for contraception.\nNorethindrone will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.\n'),(611,'norflex','Follow all directions on your prescription label. Do not take  Norflex in larger or smaller amounts or for longer than recommended.\nNorflex may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.\nNorflex is usually taken 2 times per day, once in the morning and once in the evening. Follow your doctor\'s dosing instructions.\nDo not crush, chew, or break an extended-release tablet. Swallow it whole.\nNorflex is only part of a complete program of treatment that may also include rest, physical therapy, or other pain relief measures.\nStore Norflex at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.\nKeep track of the amount of medicine used from each new bottle. Norflex is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\n Detailed Norflex dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Taking Norflex with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.\nOther drugs may interact with orphenadrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Norflex drug interactions (more detail)\nDoes Norflex interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using Norflex and call your doctor at once if you have:\na light-headed feeling, like you might pass out;\npainful or difficult urination;\nlittle or no urination;\nconfusion, anxiety, agitation, tremors, hallucinations; or\npounding heartbeats or fluttering in your chest.\nCommon side effects may include:\ndizziness, drowsiness, weakness;\nnausea, vomiting;\ndry mouth; or\nconstipation.\nThis is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.\n Norflex side effects (more detail)\n','Norflex is a muscle relaxer.\nNorflex is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.\nNorflex may also be used for purposes not listed in this medication guide.\n','You should not take  Norflex if you have urination problems, an enlarged prostate, glaucoma, a stomach ulcer or blockage in your digestive tract, trouble swallowing, or myasthenia gravis.\nBefore taking this medicine\nYou should not use Norflex if you are allergic to it, or if you have:\nurination problems;\nan enlarged prostate;\nglaucoma;\na stomach ulcer;\na blockage in your stomach or intestines;\ntrouble swallowing; or\nmyasthenia gravis.\nTo make sure Norflex is safe for you, tell your doctor if you have:\nheart disease;\na heart rhythm disorder;\ncoronary artery disease; or\nif you also use a narcotic (opioid) medication.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether orphenadrine passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.\nNorflex is not approved for use by anyone younger than 18 years old.\n',' Norflex may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDo not drink alcohol. Dangerous side effects or death can occur.\n'),(612,'nortriptyline','Usual Adult Dose for Depression:\n25 mg orally 3 to 4 times per day\n-Maximum dose: 150 mg/day\nComments:\n-The total daily dosage may be given once a day.\n-Patients should be started at lower doses, and the doses should be gradually increased.\n-When doses above 100 mg per day are given, plasma levels should be monitored and maintained in the optimum range of 50 to 150 ng/mL.\nUse: Relief of symptoms of depression\nUsual Geriatric Dose for Depression:\n30 to 50 mg orally per day, in divided doses\nComments:\n-The total daily dosage may be given once a day.\n-Patients should be started at lower doses, and the doses should be gradually increased.\nUse: Relief of symptoms of depression\n Detailed Nortriptyline dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nortriptyline can be fatal.\nOverdose symptoms may include irregular heartbeats, severe drowsiness, vision problems, confusion, hallucinations, agitation, stiff muscles, overactive reflexes, vomiting, feeling hot or cold, feeling like you might pass out, seizures, or coma.\n','Using nortriptyline with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nTell your doctor about all your other medicines, especially:\nmedicine to treat depression, anxiety, mood disorders, or mental illness;\ncold or allergy medicine (Benadryl, Sudafed, and others);\na stimulant medicine, such as diet pills or ADHD medicine;\nmedicine to treat Parkinson\'s disease;\nmedicine to treat stomach problems, motion sickness, or irritable bowel syndrome;\nmedicine to treat overactive bladder; or\nbronchodilator asthma medication.\nThis list is not complete. Other drugs may interact with nortriptyline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Nortriptyline drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to nortriptyline: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\nblurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;\nrestless muscle movements in your eyes, tongue, jaw, or neck;\na light-headed feeling, like you might pass out;\nseizure (convulsions);\nnew or worsening chest pain, pounding heartbeats or fluttering in your chest;\nsudden numbness or weakness, problems with vision, speech, or balance;\nfever, sore throat, easy bruising, unusual bleeding;\npainful or difficult urination; or\njaundice (yellowing of the skin or eyes).\nSeek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.\nCommon nortriptyline side effects may include:\nincreased blood pressure;\nnumbness or tingling in your hands or feet;\ndry mouth, nausea, vomiting, loss of appetite;\nblurred vision;\nrash, itching; or\nbreast swelling (in men or women).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nortriptyline side effects (more detail)\n','Nortriptyline is a tricyclic antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression.\nNortriptyline is used to treat symptoms of depression.\nNortriptyline is not recommended for use in children.\n','You should not use nortriptyline if you recently had a heart attack.\nDo not use nortriptyline if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine and others.\nSome young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nBefore taking this medicine\nYou should not use nortriptyline if:\nyou are allergic to it or similar medicines (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, protriptyline, trimipramine);\nyou are allergic to certain seizure medications (carbamazepine, eslicarbazepine, oxcarbazepine, rufinamide); or\nyou recently had a heart attack.\nDo not use nortriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.\nTell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson\'s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with nortriptyline could cause a serious condition called serotonin syndrome.\nTell your doctor if you have used an \"SSRI\" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.\nTo make sure nortriptyline is safe for you, tell your doctor if you have ever had:\nunexplained fainting spells;\na genetic heart condition called Brugada syndrome;\na family history of unexplained death at younger than 45 years old;\nheart disease;\na heart attack or stroke;\na seizure;\nbipolar disorder (manic-depression);\nschizophrenia or other mental illness;\na thyroid disorder;\nproblems with urination;\nnarrow-angle glaucoma; or\nif you are receiving electroshock treatment.\nSome young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nTell your doctor if you are pregnant or breastfeeding.\nNortriptyline is not approved for use by anyone younger than 18 years old.\nHow should I take nortriptyline?\nTake nortriptyline exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nMeasure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nIf you need surgery, tell your surgeon you currently use nortriptyline. You may need to stop for a short time.\nYou may have unpleasant withdrawal symptoms if you stop using nortriptyline suddenly. Ask your doctor how to safely stop using this medicine.\nIt may take a few weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or hazardous activity until you know how nortriptyline will affect you. Your reactions could be impaired.\nNortriptyline could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.\n'),(613,'norvasc','Take Norvasc exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nYou may take Norvasc with or without food. Take the medicine at the same time each day.\nYour blood pressure will need to be checked often.\nYour chest pain may become worse when you first start taking Norvasc or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.\nIf you are being treated for high blood pressure, keep using Norvasc even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.\nYour hypertension or heart condition may be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or stop taking any of your medications without your doctor\'s advice. This is especially important if you also take nitroglycerin.\nNorvasc is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.\nStore at room temperature away from moisture, heat, and light.\n Detailed Norvasc dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include rapid heartbeats, redness or warmth in your arms or legs, or fainting.\n','Tell your doctor about all your current medicines and any you start or stop using, especially:\nnitroglycerin;\nsimvastatin (Zocor, Simcor, Vytorin); or\nany other heart or blood pressure medications.\nThis list is not complete. Other drugs may interact with amlodipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Norvasc drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Norvasc: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nIn rare cases, when you first start taking Norvasc, your angina may get worse or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.\nCall your doctor at once if you have:\npounding heartbeats or fluttering in your chest;\nworsening chest pain;\nswelling in your feet or ankles;\nsevere drowsiness; or\na light-headed feeling, like you might pass out.\nCommon Norvasc side effects may include:\ndizziness, drowsiness;\nfeeling tired;\nstomach pain, nausea; or\nflushing (warmth, redness, or tingly feeling);\nswelling in your ankles and lower part of your legs.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Norvasc side effects (more detail)\n','Norvasc (amlodipine) is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.\nNorvasc is used to treat chest pain (angina) and other conditions caused by coronary artery disease.\nNorvasc is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.\nAmlodipine is for use in adults and children who are at least 6 years old.\n','Before taking Norvasc, tell your doctor if you have congestive heart failure or liver disease.\nDrinking alcohol can further lower your blood pressure and may increase certain side effects of Norvasc.\nIf you are being treated for high blood pressure, keep using Norvasc even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nNorvasc is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.\nTell your doctor about all other heart or blood pressure medications you are taking.\nYour chest pain may become worse when you first start taking this medicine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.\nBefore taking this medicine\nYou should not take Norvasc if you are allergic to amlodipine.\nTo make sure Norvasc is safe for you, tell your doctor if you have ever had:\nliver disease; or\na heart valve problem called aortic stenosis.\nTell your doctor if you are pregnant or plan to become pregnant. It is not known whether Norvasc will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.\nAmlodipine can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breastfeeding.\nNorvasc is not approved for use by anyone younger than 6 years old.\n','Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\n'),(614,'novolog','Use NovoLog exactly as it was prescribed for you. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nNovoLog is injected under the skin, or into a vein through an IV. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.\nYour care provider will show you the best places on your body to inject NovoLog. Use a different place each time you give an injection. Do not inject into the same place two times in a row.\nDo not inject this medicine into skin that is damaged, tender, bruised, pitted, thickened, scaly, or has a scar or hard lump.\nAfter using NovoLog, you should eat a meal within 5 to 10 minutes.\nIf you use an injection pen, use only the injection pen that comes with NovoLog. Attach a new needle before each use. Do not transfer the insulin from the pen into a syringe or infusion pump.\nIf you use this medicine with an insulin pump, do not mix or dilute NovoLog with any other insulin. Infusion pump tubing, catheters, and the needle location on your skin should be changed every 3 days. Change the medicine in the reservoir every 6 days.\nPrepare an injection only when you are ready to give it. This medicine should be clear and colorless. Do not use the medicine if it has changed colors or has particles in it. Call your pharmacist for new medicine.\nNever share an injection pen, cartridge, or syringe with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.\nUse a disposable needle or syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof \"sharps\" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.\nLow blood sugar (hypoglycemia) can happen to anyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.\nYour doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.\nAlso watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.\nBlood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, medications, or skipping meals. Ask your doctor before changing your insulin dose or medication schedule.\nNovoLog is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor\'s instructions very closely.\nKeep this medicine in its original container protected from heat and light. Do not draw insulin from a vial into a syringe until you are ready to give an injection. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.\nStoring unopened (not in use) NovoLog:\nRefrigerate and use until expiration date; or\nStore at room temperature and use within 28 days.\nStoring opened (in use) NovoLog:\nStore the vial in a refrigerator or at room temperature and use within 28 days.\nStore the cartridge or injection pen at room temperature (do not refrigerate) and use within 28 days. Do not store the injection pen with a needle attached.\nUse a needle and syringe only once and then place them in a puncture-proof \"sharps\" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.\nRead all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.\nWear a diabetes medical alert tag in case of emergency. Any medical care provider who treats you should know that you have diabetes.\n Detailed Novolog dosage information\nWhat happens if I miss a dose?\nSince NovoLog is used before meals, you may not be on a timed dosing schedule. Whenever you use NovoLog, be sure to eat a meal within 5 to 10 minutes. Do not use extra insulin to make up a missed dose.\nKeep insulin on hand at all times. Get your prescription refilled before you run out of medicine completely.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. Insulin overdose can cause life-threatening hypoglycemia. Symptoms include drowsiness, confusion, blurred vision, numbness or tingling in your mouth, trouble speaking, muscle weakness, clumsy or jerky movements, seizure (convulsions), or loss of consciousness.\n','Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of insulin. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.\n Novolog drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to NovoLog: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.\nCall your doctor at once if you have:\nheart problems - swelling, rapid weight gain, feeling short of breath; or\nlow potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.\nCommon NovoLog side effects may include:\nlow blood sugar;\nweight gain;\nlow potassium;\nswelling in your hands and feet;\nskin rash, itching, redness, or swelling; or\nthickening or hollowing of the skin where you injected the medicine.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Novolog side effects (more detail)\nBefore taking this medicine\nYou should not use NovoLog if you are allergic to insulin aspart, or if you are having an episode of hypoglycemia (low blood sugar).\nNovoLog is not approved for use by anyone younger than 2 years old. This medicine should not be used to treat type 2 diabetes in a child of any age.\nTo make sure NovoLog is safe for you, tell your doctor if you have:\nliver or kidney disease; or\nlow levels of potassium in your blood (hypokalemia).\nTell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.\nTell your doctor if you are pregnant or breastfeeding.\nFollow your doctor\'s instructions about using insulin if you are pregnant or you become pregnant.\n','NovoLog (insulin aspart)is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood.\nNovoLog is used to improve blood sugar control in adults and children with diabetes mellitus.\nThis medicine is sometimes used together with a long-acting or intermediate-acting insulin.\nNovoLog is used to treat type 2 diabetes in adults.\nNovoLog is also used to treat type 1 diabetes in adults and children who are at least 2 years old.\n','NovoLog is a fast-acting insulin that begins to work very quickly. After using it, you should eat a meal within 5 to 10 minutes.\nNever share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.\nYou should not use NovoLog if you are having an episode of hypoglycemia (low blood sugar).\n','Insulin can cause low blood sugar. Avoid driving or operating machinery until you know how this medicine will affect you.\nAvoid medication errors by always checking the medicine label before injecting your insulin.\nAvoid drinking alcohol or using medicines that contain alcohol. Alcohol can cause low blood sugar and may interfere with your diabetes treatment.\n'),(615,'np-thyroid','Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use  NP Thyroid in larger or smaller amounts or for longer than recommended.\nWhile using desiccated thyroid, you may need frequent blood tests.\nKeep using this medicine as directed, even if you feel well. You may need to take thyroid medication for the rest of your life.\nCall your doctor if you notice any signs of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual.\nIf you need surgery, tell the surgeon ahead of time that you are using desiccated thyroid. You may need to stop using the medicine for a short time.\nStore at room temperature away from moisture and heat.\n Detailed NP Thyroid dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all medicines you use, and those you start or stop using during your treatment with desiccated thyroid, especially:\nbirth control pills or hormone replacement therapy;\na blood thinner such as warfarin, Coumadin, Jantoven;\ninsulin or diabetes medication you take by mouth;\nmedications that contain iodine (such as I-131);\nsalicylates such as aspirin, Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate; or\nsteroids such as prednisone and others.\nThis list is not complete. Other drugs may interact with desiccated thyroid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n NP Thyroid drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCommon side effects may include temporary hair loss (especially in children).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n NP Thyroid side effects (more detail)\n','Desiccated (dried) thyroid is a combination of hormones that are normally produced by your thyroid gland to regulate the body\'s energy and metabolism. Desiccated thyroid is given when the thyroid does not produce enough of this hormone on its own.\nDesiccated thyroid treats hypothyroidism (low thyroid hormone). Desiccated thyroid is also used to treat or prevent goiter (enlarged thyroid gland), and is also given as part of a medical tests for thyroid disorders.\nDesiccated thyroid should not be used to treat obesity or weight problems.\nDesiccated thyroid may also be used for purposes not listed in this medication guide.\n','You may not be able to use  NP Thyroid if you have a thyroid disorder called thyrotoxicosis, or an adrenal gland problem that is not controlled by treatment.\nCall your doctor if you have signs of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual.\nBefore taking this medicine\nSince thyroid hormone occurs naturally in the body, almost anyone can take desiccated thyroid. However, you may not be able to use this medication if you have a thyroid disorder called thyrotoxicosis, or an adrenal gland problem that is not controlled by treatment.\nTo make sure desiccated thyroid is safe for you, tell your doctor if you have:\nheart disease, angina (chest pain);\ncoronary artery disease;\ncongestive heart failure;\nany type of diabetes; or\nproblems with your adrenal gland.\nDesiccated thyroid is not expected to be harmful to an unborn baby, but your dose needs may be different during pregnancy. Tell your doctor if you become pregnant while taking this medicine.\nSmall amounts of desiccated thyroid can pass into breast milk, but this is not expected to harm a nursing baby. However, do not use this medication without telling your doctor if you are breast-feeding a baby.\n','If you also take cholestyramine (Prevalite, Questran) or colestipol (Colestid), avoid taking these medications within 4 hours before or after you take desiccated thyroid.\nAvoid taking an antacid within 4 hours before or after you take desiccated thyroid. Some antacids can make it harder for your body to absorb desiccated thyroid.\n'),(616,'nplate','Usual Adult Dose for Idiopathic (Immune) Thrombocytopenic Purpura:\nInitial dose: 1 mcg/kg subcutaneous injection once a week based on actual body weight; adjust the weekly dose by increments of 1 mcg/kg until the patients achieves a platelet count of 50 x 10(9)/L or greater\nMaintenance dose: Use the lowest dose to achieve and maintain a platelet count of 50 x 10(9)/L or greater as needed to reduce bleeding risk.\nMaximum dose: 10 mcg/kg/week\nDuration of therapy: Discontinue this drug if platelets remain insufficient to avoid clinically important bleeding after 4 weeks at the maximum dose.\nComments: In clinical studies, most patients who responded to this drug achieved and maintained platelet counts of 50 x 10(9)/L or greater with a median dose of 2 mcg/kg.\nUse: Treatment of thrombocytopenia in patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy; use only in patients with ITP whose degree of thrombocytopenia and clinical condition increases the risk for bleeding.\nUsual Pediatric Dose for Idiopathic (Immune) Thrombocytopenic Purpura:\n1 Year or Older:\nInitial dose: 1 mcg/kg subcutaneous injection once a week based on actual body weight; adjust the weekly dose by increments of 1 mcg/kg until the patients achieves a platelet count of 50 x 10(9)/L or greater\nMaintenance dose: Use the lowest dose to achieve and maintain a platelet count of 50 x 10(9)/L or greater as needed to reduce bleeding risk.\nMaximum dose: 10 mcg/kg/week\nComments:\n-Dose adjustments are based on changes in platelet counts and changes in body weight. Reassessment of body weight is recommended every 12 weeks.\n-In a pediatric placebo-controlled clinical study, the median dose was 5.5 mcg/kg.\nUse: Treatment of thrombocytopenia in patients with immune thrombocytopenia (ITP) for at least 6 months who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy; use only in patients with ITP whose degree of thrombocytopenia and clinical condition increases the risk for bleeding.\n Detailed Nplate dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss an appointment for your Nplate injection.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with romiplostim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Nplate drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nplate: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere or ongoing diarrhea;\npurple or red spots under your skin;\nsigns of an ear infection (more common in children) - fever, ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child;\nsigns of a stroke - sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;\nsigns of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or\nsigns of a blood clot in your leg - swelling, warmth, or redness in an arm or leg.\nCommon Nplate side effects may include:\nbruising;\nheadache;\ndizziness;\njoint pain, muscle weakness or tenderness;\npain in your arms, legs, or shoulder;\nnumbness or tingling in your hands or feet;\ntrouble sleeping;\nstomach pain, indigestion, nausea, vomiting, diarrhea;\ncough, wheezing, chest tightness, trouble breathing;\nstuffy nose, sneezing, sinus pain; or\npain in your mouth and throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nplate side effects (more detail)\n','Nplate (romiplostim) is a man-made form of a protein that increases production of platelets (blood-clotting cells) in your body.\nNplate is a prescription medicine used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP), a bleeding condition caused by a lack of platelets in the blood.\nNplate is for use in adults and children who are at least 1 year old.\nNplate is also used to treat people including newborns who have been exposed to high levels of radiation (acute radiation syndrome). The effectiveness of Nplate for this use was only studied in animals, because it could not be studied in people.\n','Nplate is not a cure for ITP and it will not make your platelet counts normal if you have this condition.\nNplate may increase your risk of a blood clot or stroke. Call your doctor right away if you have signs of a blood clot, such as sudden numbness or weakness on one side of the body, chest pain, problems with speech or balance, warmth or swelling in an arm or leg.\nBefore you use Nplate, tell your doctor if you have kidney or liver disease.\nUsing Nplate long-term can cause harmful effects on your bone marrow that may result in serious blood cell disorders. To be sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Do not miss any scheduled visits to your doctor.\nIt may take up to 4 weeks of using this medicine before it is completely effective in preventing bleeding episodes. Talk with your doctor if you have any bruising or bleeding episodes after 4 weeks of treatment.\nAfter you stop using Nplate, your risk of bleeding may be even higher than it was before you started treatment. Be extra careful to avoid cuts or injury for at least 2 weeks after you stop using Nplate. Your blood will need to be tested weekly during this time.\nBefore taking this medicine\nYou should not use Nplate if you are allergic to romiplostim.\nUsing Nplate may increase your risk of developing blood cancers, especially if you have a myelodysplastic syndrome (bone marrow failure disorder, sometimes called \"preleukemia\"). Talk with your doctor if you have concerns about this risk.\nTo make sure Nplate is safe for you, tell your doctor if you have ever had:\nblood or bone marrow cancer such as leukemia, or myelodysplastic syndrome;\nbleeding problems or a blood clot;\nsurgery to remove your spleen; or\nliver disease.\nIt is not known whether romiplostim will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of romiplostim on the baby.\nYou should not breastfeed while using Nplate.\nHow is Nplate given?\nNplate is injected under the skin, usually once per week. A healthcare provider will give you this injection.\nIt may take up to 4 weeks of before Nplate is completely effective in preventing bleeding episodes. Keep receiving the medication as directed. Talk with your doctor if you have any bruising or bleeding episodes after 4 weeks of treatment.\nUsing Nplate long-term can cause harmful effects on your bone marrow that may result in serious blood cell disorders. You will need frequent blood tests. Your treatment with this medicine may be delayed or permanently discontinued based on the results.\nAfter you stop using Nplate, your risk of bleeding may be even higher than it was before you started treatment. Be extra careful to avoid cuts or injury for at least 2 weeks after you stop using Nplate. Your blood will need to be tested weekly during this time.\n','Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.\n'),(617,'nubeqa','Usual Adult Dose for Prostate Cancer:\n600 mg orally 2 times a day\nComments:\n-Patients receiving this drug should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had a bilateral orchiectomy.\nUse: For nonmetastatic castration resistant prostate cancer (nmCRPC)\n Detailed Nubeqa dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may intweact with darolutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Nubeqa drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nubeqa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere ongoing nausea or diarrhea;\npainful or difficult urination;\nblood in your urine;\nsevere headache, blurred vision, pounding in your neck or ears;\nslow heart rate, weak pulse, fainting, slow breathing (breathing may stop);\nsigns of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or\nsigns of a lung infection - fever, chills, cough with mucus, chest pain, shortness of breath.\nYour cancer treatments may be delayed if you have certain side effects.\nCommon Nubeqa side effects may include:\nfeeling tired;\npain in your arms, hands, legs, or feet;\nrash;\nlow white blood cells; or\nabnormal liver function tests.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nubeqa side effects (more detail)\n','Nubeqa (darolutamide) a prescription medicine used to treat prostate cancer that has not spread to other parts of your body.\nNubeqa is given after surgery or other treatments did not work or have stopped working.\nIt is not known if Nubeqa is safe and effective in children or in females.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nTo make sure Nubeqa is safe for you, tell your doctor if you have ever had:\nliver or kidney disease.\nAlthough Nubeqa is not for use by women, this medicine can harm an unborn baby or cause a miscarriage if a woman is exposed to it during pregnancy.\nUse effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while you are using Nubeqa.\nThis medicine may affect fertility (your ability to have children). However, it is important to use birth control to prevent pregnancy because darolutamide can harm an unborn baby.\nHow should I take Nubeqa?\nTake Nubeqa exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nTake with food.\nSwallow the tablet whole and do not crush, chew, or break it.\nIf you have not had surgery to lower the amount of testosterone in your body, your doctor may also prescribe a gonadotropin-releasing hormone (GnRH) medicine such as Eligard, Lupron, Trelstar, Zoladex, or Vantas. Keep using your GnRH as directed.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(618,'nucynta','Usual Adult Dose for Pain:\nIndividualize therapy taking into consideration severity of pain, response to therapy, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse:\nImmediate-Release:\nInitial dose: 50 to 100 mg orally every 4 to 6 hours as needed for pain\n-Day 1: A second dose may be administered as soon as 1 hour after the first dose if needed\n-Subsequent dosing: 50, 75, or 100 mg orally every 4 to 6 hours; adjust dosing to maintain adequate analgesia with acceptable tolerability\nMaximum dose: 700 mg on day 1; 600 mg/day on subsequent days\nComments:\n-Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.\n-Monitor closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and with each dose increase.\n-Due to risks of addiction, abuse, and misuse, even at recommended doses, reserve use for patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products) have not been tolerated, or are not expected to be tolerated, or have not provided adequate analgesia, or are not expected to provide adequate analgesia.\nUsual Adult Dose for Chronic Pain:\nIndividualize therapy taking into consideration severity of pain, response to therapy, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse:\n-Discontinue all other tapentadol and tramadol products prior to starting tapentadol extended-release tablets\nEXTENDED RELEASE TABLETS:\nInitial dose: 50 mg orally twice a day\n-Individually titrate to a dose that provides adequate analgesia and minimizes adverse reactions; dose increases should not exceed 50 mg twice a day every 3 days\nMaintenance dose: 100 mg to 250 mg orally twice a day\nMaximum dose: 500 mg/day\nCONVERSION from IMMEDIATE-RELEASE to EXTENDED-RELEASE:\n-Provide same total daily dose of tapentadol divided into 2 equal doses and administered orally twice a day approximately 12 hours apart\nCONVERSION from Other Opioids:\n-As there are no established conversion ratios from other opioids, initiate at 50 mg orally every 12 hours\n-Close observation and frequent titration are warranted until pain is controlled; monitor for signs and symptom of opioid withdrawal\n-Provide rescue medication with an appropriate dose of an immediate-release analgesic as appropriate\nComments:\n-For patients with breakthrough pain a rescue medication with an appropriate dose of an immediate-release analgesic may be needed.\n-If the level of pain increases after dose stabilization, attempt to identify the source of increased pain before increasing dose.\n-Because of the risks of addiction, abuse, and misuse even at recommended doses, use should be limited to patients for whom alternative treatment options (e.g. non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient pain management.\n-This medicine is not for use as an as-needed analgesic.\n Detailed Nucynta dosage information\nWhat happens if I miss a dose?\nSince Nucynta is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nDo not take extra medicine to make up a missed dose. Do not take more than your prescribed dose in a 24-hour period.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or person using opioid medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.\nYour doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don\'t wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.\nAnyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.\n','Many other drugs can be dangerous when used with Nucynta. Tell your doctor if you also use:\nmedicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder;\nother opioid medicines;\na benzodiazepine sedative like Valium, Klonopin, or Xanax;\nsleep medicine, muscle relaxers, or other drugs that make you drowsy; or\ndrugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson\'s disease.\nThis list is not complete. Many drugs may interact with tapentadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Nucynta drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nucynta: hives; chest pain, fast heartbeats, difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nnoisy breathing, sighing, shallow breathing, breathing that stops;\na light-headed feeling, like you might pass out;\nagitation, feeling hot;\nsevere drowsiness or dizziness, confusion, problems with speech or balance;\na seizure;\nserotonin syndrome - agitation, hallucinations, fever, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, diarrhea; or\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.\nSerious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.\nCommon Nucynta side effects may include:\nconstipation, nausea, vomiting, stomach pain;\nheadache, feeling tired; or\ndrowsiness, dizziness.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nucynta side effects (more detail)\n','Nucynta (tapentadol) is an opioid pain medication. An opioid is sometimes called a narcotic.\nNucynta is a prescription medicine that is used to treat moderate to severe pain.\nNucynta ER (extended-release) is for around-the-clock treatment of pain that is not controlled by other medicines. Nucynta ER is not for use on an as-needed basis for pain.\n','Do not use Nucynta if you have used a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.\nYou should not use Nucynta if you have severe breathing problems, or a bowel obstruction called paralytic ileus.\nNucynta can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take Nucynta in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release tablet. Swallow it whole to avoid exposure to a potentially fatal dose.\nTapentadol may be habit-forming, even at regular doses. Take Nucynta exactly as prescribed by your doctor. Never share the medicine with another person. MISUSE OF NARCOTIC PAIN MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Keep the medication in a place where others cannot get to it.\nTell your doctor if you are pregnant. Tapentadol may cause life-threatening withdrawal symptoms in a newborn if the mother has taken this medicine during pregnancy.\nFatal side effects can occur if you use Nucynta with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore taking this medicine\nYou should not use Nucynta if you are allergic to tapentadol, or if you have:\nsevere asthma or breathing problems;\na stomach or bowel obstruction (including paralytic ileus); or\nif you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.\nTo make sure Nucynta is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea (breathing that stops during sleep);\na head injury, brain tumor, or seizures;\nalcoholism or drug addiction, mental illness;\nurination problems,\nliver or kidney disease; or\nproblems with your gallbladder, pancreas, thyroid, or adrenal gland.\nIf you use opioid medicine while you are pregnant, your baby could become dependent tapentadol. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.\nAsk a doctor before using Nucynta if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.\nDo not give Nucynta to a child.\nHow should I take Nucynta?\nTake Nucynta exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use Nucynta in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.\nNever share Nucynta with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.\nStop taking all other medications that contain tapentadol or tramadol when you start taking Nucynta ER extended-release tablets.\nTake Nucynta with a full glass of water at the same times each day, with or without food.\nDo not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose.\nNucynta can cause constipation. Talk to your doctor before using a laxative or stool softener to treat or prevent this side effect.\nNever crush a pill to inhale the powder or inject it into your vein. This could result in death.\nYou may have withdrawal symptoms if you stop using Nucynta suddenly. Ask your doctor before stopping the medicine.\nStore at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.\nDo not keep leftover Nucynta. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(619,'nuedexta','Usual Adult Dose for Pseudobulbar Affect:\n-Initial Dose: Days 1 to 7: Dextromethorphan 20 mg-quinidine 10 mg orally once a day\n-Maintenance Dose: Day 8 and thereafter: Dextromethorphan 20 mg-quinidine 10 mg orally every 12 hours\n-Maximum dose: Dextromethorphan 40 mg-quinidine 20 mg orally per day\nComments: The need for continued treatment should be reassessed periodically as spontaneous improvement of PBA occurs in some patients.\nUse: Treatment of Pseudobulbar Affect (PBA)\n Detailed Nuedexta dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nDo not take more than 2 capsules in a 24-hour period.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose can cause severe dizziness, confusion, double vision, ringing in your ears, hearing loss, vomiting, fast or irregular heart rate, weak or shallow breathing, or seizure (convulsions).\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nNuedexta can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.\nMany drugs can interact with dextromethorphan and quinidine, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Nuedexta drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Nuedexta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using this medicine and call your doctor at once if you have:\nfast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);\neasy bruising or bleeding (nosebleeds, bleeding gums);\npain or burning when you urinate;\nliver problems - fever, right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well; or\nlupus-like symptoms - muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight.\nSeek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.\nCommon Nuedexta side effects may include:\ndizziness, weakness;\ndiarrhea, gas, vomiting;\nswelling in your hands or feet;\nflu symptoms, cough; or\nabnormal liver function tests.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nuedexta side effects (more detail)\n','Nuedexta contains a combination of dextromethorphan and quinidine. Dextromethorphan affects the signals in the brain that trigger cough reflex and is generally used as a cough suppressant. Quinidine affects the way that the heart beats and is generally used in people with certain heart rhythm disorders.\nNuedexta is used for the treatment of pseudobulbar affect (PBA).\nNuedexta treats involuntary outbursts of crying or laughing in people with certain neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis (ALS, or Lou Gehrig\'s disease).\n','You should not use Nuedexta if you have heart failure, a serious heart condition called \"AV block\" (unless you have a pacemaker), or a history of Long QT syndrome or life-threatening heart rhythm disorder.\nDo not use Nuedexta if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.\nYou also should not take Nuedexta if you are also taking mefloquine, quinidine, or quinine, or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications.\nSome medicines can interact with Nuedexta and should not be used at the same time. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine.\nYou should not take Nuedexta if you are also taking quinidine (Quin-G), quinine (Qualaquin), or mefloquine (Lariam), or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications.\nBefore taking this medicine\nYou should not take Nuedexta if you are allergic to dextromethorphan or quinidine, or if you have:\nheart failure;\na history of life-threatening heart rhythm disorder;\nlong QT syndrome (in you or a family member);\na serious heart condition called \"AV block\" (unless you have a pacemaker); or\nif you also use mefloquine, quinidine, or quinine.\nYou also should not take Nuedexta if you have ever had any of the following problems caused by taking mefloquine, quinidine, or quinine:\nbruising or bleeding;\nhepatitis;\nan allergic reaction; or\nlupus-like symptoms (joint pain, fever, skin rash on your cheeks).\nDo not use Nuedexta if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. After you stop taking Nuedexta, you must wait at least 14 days before you start taking an MAOI.\nNuedexta can cause a serious heart problem. You should not take this medicine if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.\nBe sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson\'s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with dextromethorphan and quinidine and cause a serious condition called serotonin syndrome.\nTo make sure Nuedexta is safe for you, tell your doctor if you have ever had:\nheart disease, high blood pressure, coronary artery disease;\nslow heartbeats or any type of heart rhythm disorder;\nan electrolyte imbalance (such as low levels of potassium or magnesium in your blood);\nmyasthenia gravis; or\ntrouble with balance or walking.\nTell your doctor if you are pregnant or breastfeeding.\nNuedexta is not approved for use by anyone younger than 18 years old.\nHow should I take Nuedexta?\nTake Nuedexta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nNuedexta is usually taken once per day for 7 days, and then once every 12 hours. Follow your doctor\'s dosing instructions very carefully.\nYou may take Nuedexta with or without food.\nYour doctor will need to check your progress on a regular basis. You may need medical tests to help your doctor determine how long to treat you with Nuedexta.\nStore at room temperature away from moisture and heat.\n','Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness can cause falls, accidents, or severe injuries.\nGrapefruit may interact with dextromethorphan and quinidine and lead to unwanted side effects. Avoid the use of grapefruit products.\nAsk a doctor or pharmacist before using any cough or cold medication that may contain dextromethorphan. Taking certain products together can cause you to get too much dextromethorphan. Check the label of medicines such as Delsym, Robitussin Maximum Strength, Vicks 44, and others.\n'),(620,'nurtec-odt','\nTake Nurtec ODT exactly how your healthcare provider tells you to.\nTake this medicine once a day as needed. You should not take more than 1 tablet in 24 hours.\nIt is not known if it is safe to take this medicine for more than 15 migraine headaches in 30 days.\nTo take Nurtec ODT:\nUse dry hands when opening the blister pack.\nPeel back the foil covering of one blister and gently remove the orally disintegrating tablet. Do not push the orally disintegrating tablet through the foil.\nAs soon as the blister is opened, remove the orally disintegrating tablet and place on or under the tongue.\nthe orally disintegrating tablet will dissolve and no drink or water is needed.\nTake the medicine immediately after opening the blister pack. Do not store the orally disintegrating tablets outside the blister pack for future use.\nIf you take too much Nurtec ODT, go to the nearest emergency room right away.\n Detailed Nurtec ODT dosage information\n',NULL,'Nurtec ODT may cause serious side effects including:\nAllergic reactions. Allergic reactions, including trouble breathing and rash, can happen after you take Nurtec ODT. This can happen days after you take this medicine. Call your healthcare provider or get emergency help right away if you have any of the following symptoms, which may be part of an allergic reaction:\nSwelling of the face, mouth, tongue, or throat\nTrouble breathing\nThe most common side effect is:\nnausea\nThis is not the only possible side effect.  Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800 FDA-1088.\n Nurtec ODT side effects (more detail)\nHow should I store Nurtec ODT?\nStore in the blister package that it comes in.\nStore at room temperature between 68°F to 77°F (20°C to 25°C).\nKeep all medicines out of the reach of children and pets.\nGeneral information about safe and effective use\nMedicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.\nWhat are the ingredients in Nurtec ODT?\nActive ingredient: rimegepant\nInactive ingredients: benzyl alcohol, eucalyptol, gelatin, limonene, mannitol, menthol, menthone, menthyl acetate, sucralose, and vanillin\n','Nurtec ODT (rimegepant sulfate) is a prescription medicine that blocks nerve cell receptors that trigger intense pain.\nNurtec ODT is used for the acute treatment of migraine attacks, with or without aura, in adults.\nNurtec ODT is also used as a preventive treatment of episodic migraine.\nWho should not take this medicine?\nYou should not take Nurtec ODT if you are:\nallergic to rimegepant or any of the other ingredients contained in the orally disintegrating tablets.\nSee the end of this leaflet for a complete list of ingredients.\n',NULL,NULL),(621,'nystatin','Usual Adult Dose for Oral Thrush:\nRecommended dose: 400,000 to 600,000 units of the oral suspension orally 4 times a dayDuration of therapy: At least 48 hours after symptoms have disappeared and cultures demonstrate eradicationComment:-For the treatment of oral candidiasis, the suspension should be retained in the mouth for as long as possible before swallowing.Use: Treatment of oral candidiasis in the oral cavity\nUsual Adult Dose for Intestinal Candidiasis:\nRecommended dose: 500,000 to 1,000,000 units of the tablet formulation orally 3 times a dayDuration of therapy: At least 48 hours after clinical cureUse: Treatment of non-esophageal mucus membrane gastrointestinal candidiasis\nUsual Pediatric Dose for Oral Thrush:\n1 month to 12 months:-Recommended dose: 200,000 units of the oral suspension orally 4 times a day1 year to 18 years:-Recommended dose: 400,000 to 600,000 units of the oral suspension orally 4 times a day-Duration of therapy: At least 48 hours after symptoms have disappeared and cultures demonstrate eradicationComments:-Limited data in premature and low birth weight infants indicated efficacy with 100,000 units orally 4 times a day.-Infants should avoid feeding for 5 to 10 minutes after administration.-For the treatment of oral candidiasis, the suspension should be retained in the mouth for as long as possible before swallowing.Use: Treatment of oral candidiasis in the oral cavity\n Detailed Nystatin dosage information\n','Other drugs may interact with nystatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Nystatin drug interactions (more detail)\nDoes Nystatin interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nfast heart rate;\ntrouble breathing; or\nsevere skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.\nCommon side effects may include:\nmouth irritation;\nupset stomach, nausea, vomiting, diarrhea; or\nskin rash.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Nystatin side effects (more detail)\n','Nystatin is an antifungal medication that fights infections caused by fungus.\nNystatin when taken by mouth is used to treat yeast infections in the mouth or stomach.\nOral nystatin is not absorbed into your bloodstream and will not treat fungal infections in other parts of the body or on the skin.\nNystatin may also be used for purposes other than those listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use nystatin if you are allergic to it.\nIt is not known whether nystatin will harm an unborn baby. Tell your doctor if you are pregnant.\nIt is not known whether nystatin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nDo not give  nystatin to a child without medical advice.\nHow should I take nystatin?\nFollow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nTake this medicine with a full glass of water.\nShake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nWhen taking liquid nystatin to treat a yeast infection of the mouth, you may need to hold the medicine in your mouth for as long as possible. This allows the medicine to stay in contact with the infected area. Follow your doctor\'s instructions.\nDo not share this medicine with another person, even if they have the same symptoms you have.\nUse this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medicine. Nystatin will not treat a viral infection such as the flu or a common cold.\nNystatin is usually given for up to 48 hours after lab tests show that the infection has cleared.\nStore the Bio-Statin brand of nystatin in the refrigerator. Do not freeze.\nOther brands or forms of this medicine may be stored at room temperature away from moisture and heat.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Do not use nystatin to treat any condition that has not been checked by your doctor.\n'),(622,'ocrevus','Usual Adult Dose for Multiple Sclerosis:\nInitial dose: 300 mg IV followed 2 weeks later by a second 300 mg IV infusion\nMaintenance dose: 600 mg IV every 6 months\nRECOMMENDED INFUSION RATES:\nINFUSION 1: (300 mg of this drug in 250 mL 0.9% sodium chloride injection): Start at 30 mL/hr and increase by 30 mL/hr every 30 minutes to a maximum of 180 mL/hr; duration of 2.5 hours or longer\nINFUSION 2 (TWO WEEKS LATER): (300 mg of this drug in 250 mL 0.9% sodium chloride injection): Start at 30 mL/hr and increase by 30 mL/hr every 30 minutes to a maximum of 180 mL/hr; duration of 2.5 hours or longer\nSUBSEQUENT INFUSIONS:\n-OPTION 1 (600 mg of this drug in 500 mL 0.9% sodium chloride injection): Start at 40 mL/hr and increase by 40 mL/hr every 30 minutes to a maximum of 200 mL/hr; duration of 3.5 hours or longer\nOR\n-OPTION 2 if no prior serious infusion reaction (600 mg of this drug in 500 mL 0.9% sodium chloride injection): Start at 100 mL/hr for the first 15 minutes and increase to 200 mL/hr for the next 15 minutes; increase to 250 mL/hr for the next 30 minutes; increase to 300 mL/hr for the remaining 60 minutes; duration of 2 hours or longer\nUses:\n-For relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease\n-Primary progressive MS\n Detailed Ocrevus dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss a dose of Ocrevus.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all other medicines you have recently used to treat multiple sclerosis.\nOther drugs may interact with ocrelizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Ocrevus drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Ocrevus: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSome side effects may occur during the injection or up to 24 hours later. Tell your caregiver right away if you feel dizzy, tired, nauseated, light-headed, feverish, itchy, warm and tingly, or if you have a skin rash, headache, fast heartbeats, chest tightness, pain or irritation in your throat, or trouble breathing.\nCall your doctor at once if you have:\nfast heart beats, tiredness;\nheadache, nausea, dizziness;\nitchy skin, rash, hives;\nfever, chills, cough;\nthroat pain or irritation;\nwheezing, breathing problem, feeling short of breath;\nflushing (sudden warmth, redness, or tingly feeling);\nskin sores, blisters, pus, or oozing;\ncold sores or fever blisters on or around your lips;\nnerve pain (tingling, burning pain, \"pins and needles\" feeling);\nmood or behavior changes, confusion, memory problems;\nweakness on one side of your body; or\nproblems with vision, speech, or muscle movement.\nYour treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon Ocrevus side effects may include:\nskin infections;\nreactions to an injection; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ocrevus side effects (more detail)\n','Ocrevus (ocrelizumab) is a monoclonal antibody that affects the actions of the body\'s immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.\nOcrevus is used to treat primary progressive multiple sclerosis and relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).\nOcrevus may also be used for purposes not listed in this medication guide.\n','Ocrevus may cause unpleasant side effects. Some side effects may occur during the injection or up to 24 hours later. Tell your caregiver if you feel dizzy, nauseated, itchy, or have chest tightness, throat irritation, or trouble breathing,.\nOcrevus affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, skin sores or blisters, itching, tingling, burning pain, or problems with speech, thought, vision, or muscle movement.\nIf you\'ve ever had hepatitis B, it may become active or get worse while you are using or after you stop using ocrelizumab. You may need frequent liver function tests for several months.\nBefore taking this medicine\nYou should not be treated with Ocrevus if you are allergic to ocrelizumab, or if you have:\nactive infection with hepatitis B.\nYour doctor may perform tests to make sure you do not have hepatitis B or other infections.\nYou should not receive any \"live\" or \"live-attenuated\" vaccine, within the 4 weeks before you start treatment with Ocrevus. If you need a \"non-live\" vaccine, you should receive it at least 2 weeks before you start treatment with ocrelizumab.\nAlso tell your doctor if:\nyou have any type of infection;\nyou are a carrier of hepatitis B; or\nyou have ever used medicine that can weaken your immune system.\nUsing Ocrevus may increase your risk of developing certain types of cancer, such as breast cancer. Ask your doctor about your specific risk.\nIt is not known whether Ocrevus will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.\nIf you are pregnant, you will need to tell your baby\'s doctor if you used ocrelizumab during pregnancy, especially before the baby receives any childhood vaccines.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of ocrelizumab on the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nOcrevus is not approved for use by anyone younger than 18 years old.\nHow is Ocrevus given?\nOcrevus is injected into a vein through an IV. A healthcare provider will give you this injection.\nYour doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Ocrevus.\nYou may be given other medications to prevent certain side effects of ocrelizumab.\nYour first dose will be split into 2 separate infusions. You will receive these infusions 2 weeks apart. The following doses will be given once every 6 months.\nOcrevus must be given slowly, and the infusion can take from 2.5 to 3.5 hours to complete.\nYou may be given other medications to help prevent serious side effects of ocrelizumab.\nYou will be watched closely for at least 1 hour after receiving Ocrevus, to make sure you do not have an allergic reaction to the medication.\nOcrelizumab affects your immune system. You may get infections more easily, even serious or fatal infections. You will need frequent medical tests.\nIf you\'ve ever had hepatitis B, this virus may become active or get worse during treatment with ocrelizumab or in the months after you stop using this medicine. You may need frequent liver function tests while using this medicine and for several months after your last dose.\n','Do not receive a \"live\" vaccine while using Ocrevus, or within 4 weeks before you start using this medicine. You could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.\nDo not receive a \"non-live\" vaccine while using Ocrevus or within 2 weeks before you start using this medicine. Non-live vaccines include hepatitis A, polio, rabies, and a yearly flu shot.\n'),(623,'octreotide','Take octreotide only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.\nTake octreotide with a glass of water on an empty stomach, at least 1 hour before or at least 2 hours after a meal.\nSwallow the delayed-release capsule whole. Do not crush, break, or chew it.\nDosing\nThe dose of octreotide will be different for different patients. Follow your doctor\'s orders or the directions on the label. The following information includes only the average doses of octreotide. If your dose is different, do not change it unless your doctor tells you to do so.\nThe amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.\nFor oral dosage form (delayed-release capsules):\nFor acromegaly:\nAdults—At first, 20 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 80 mg per day.\nChildren—Use and dose must be determined by your doctor.\nMissed dose\nIf you miss a dose of octreotide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.\nStorage\nKeep out of the reach of children.\nDo not keep outdated medicine or medicine no longer needed.\nAsk your healthcare professional how you should dispose of any medicine you do not use.\nStore in the refrigerator. Do not freeze.\nYou may keep the opened medicine at room temperature for up to 1 month. Throw away any unused medicine after 1 month.\n Detailed Octreotide dosage information\n',NULL,'Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\nCheck with your doctor immediately if any of the following side effects occur:\nMore common\nBladder pain\nbloody or cloudy urine\nblurred vision\nchest tightness\nchills\ncough\ndiarrhea\ndifficult, burning, or painful urination\ndry mouth\nfever\nflushed, dry skin\nfrequent urge to urinate\nfruit-like breath odor\ngaseous stomach pain\ngeneral feeling of discomfort or illness\nheadache\nincreased hunger\nincreased thirst\nincreased urination\njoint pain\nloss of appetite\nlower back or side pain\nmuscle aches or pains\nnausea\npain or tenderness around the eyes and cheekbones\nrecurrent fever\nshivering\nsore throat\nstomach pain or fullness\nstuffy or runny nose\nsweating\nswelling of the hands, ankles, feet, or lower legs\ntrouble breathing\ntrouble sleeping\nunexplained weight loss\nunusual tiredness or weakness\nvomiting\nyellow eyes or skin\nLess common\nAnxiety\nbody aches or pain\nburning feeling in the chest or stomach\ncold sweats\nconfusion\nconstipation\ncool, pale skin\ndepressed mood\ndizziness\ndry skin and hair\near congestion\nfainting\nfast, slow, or irregular heartbeat\nhair loss\nhoarseness or husky voice\nindigestion\nloss of consciousness\nloss of voice\nmuscle cramps or stiffness\nnervousness\nnightmares\npounding in the ears\nseizures\nshakiness\nslurred speech\nsneezing\nstomach upset or tenderness\nweight gain\nIncidence not known\nBlack, tarry stools\nbleeding gums\nblindness\nbloating\nblood in vomit\nchange in the frequency or amount of urine\nchanges in vision\nchest pain or discomfort\ndark urine\ndarkening of the skin\ndeafness\ndecreased vision\ndizziness, fainting, or lightheadedness when getting up suddenly from lying or sitting position\ndouble vision\neye pain\nhives, skin rash\nitching, pain, redness, swelling, tenderness, or warmth of the skin\nlight-colored stools\nloss of appetite\nmigraine headache\npain or discomfort in the arms, jaw, back, or neck\npale skin\npaleness or cold feeling in the fingertips and toes\npinpoint red spots on the skin\nproblems with speech or speaking\npuffiness or swelling of the eyelids or around the eyes, face, lips, or tongue\nsevere cramping\nsores, ulcers, or white spots on the lips or in the mouth\ntearing\ntingling or pain in the fingers or toes when exposed to cold temperature\nunusual bleeding or bruising\nvomiting of blood or material that looks like coffee grounds\nweakness of the muscles in your face\nSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:\nMore common\nDifficulty in moving\njoint swelling or redness\nlack or loss of strength\npassing gas\npressure in the stomach\nswelling of the abdominal or stomach area\nLess common\nBleeding after defecation\nuncomfortable swelling around the anus\nIncidence not known\nDecreased interest in sexual intercourse\ninability to have or keep an erection\nloss in sexual ability, desire, drive, or performance\nswelling of the breasts or breast soreness in both females and males\nunexpected or excess milk flow from breasts\nOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.\nCall your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.\n Octreotide side effects (more detail)\n','Octreotide is used for the long-term treatment of acromegaly (a growth hormone disorder) in patients who have been previously treated with octreotide or lanreotide. Octreotide works by reducing the amount of growth hormone that the body produces.\nOctreotide is available only with your doctor\'s prescription.\n','It is very important that your doctor check your progress at regular visits to make sure that octreotide is working properly. Blood and urine tests may be needed to check for unwanted effects.\nOctreotide may increase your risk of having gallstones (cholelithiasis), which may lead to swelling of the gallbladder (cholecystitis), bile ducts (cholangitis), or pancreas (pancreatitis). Check with your doctor right away if you have severe stomach pain with nausea and vomiting, indigestion, fever, chills, pains in the stomach or side, possibly radiating to the back, fast heartbeat, dark urine, bloating, or yellow eyes or skin.\nOctreotide may cause your blood sugar levels to rise or fall. It may cover up signs of hypoglycemia (low blood sugar), such as a change in your pulse rate. If you notice a change in the results of your blood sugar or urine sugar test, check with your doctor.\nOctreotide may cause hypothyroidism (underactive thyroid gland). Check with your doctor right away if you have constipation, a depressed mood, dry skin and hair, cold skin, hair loss, hoarseness or husky voice, muscle cramps and stiffness, a slow heartbeat, weight gain, or unusual tiredness or weakness.\nContact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, slow, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.\nOctreotide may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after using octreotide.\nOctreotide may improve fertility in some women, which could increase the risk for unplanned pregnancies. Talk to your doctor if you have any concerns.\nBefore you have any medical tests, tell the medical doctor in charge that you are using octreotide. The results of some tests may be affected by octreotide.\nDo not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.\n',NULL),(624,'odefsey','Take Odefsey exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nTake Odefsey one time per day with a meal. Do not miss a dose.\nIf a child is using this medicine, tell your doctor if the child has any changes in weight. Doses are based on weight in children, and any changes may affect your child\'s dose.\nWhile using Odefsey, you may need frequent blood tests. Your bone density may also need to be tested.\nIf you have hepatitis B you may develop liver symptoms after you stop taking this medication, even months after stopping. Your doctor may want to check your liver function for several months after you stop using this medicine.\nHIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor\'s advice. Every person with HIV or AIDS should remain under the care of a doctor.\nWhen your Odefsey supply starts to run low, get more from your healthcare provider or pharmacy. This is very important because the amount of virus in your blood may increase if the medicine is stopped for even a short time. The virus may develop resistance to Odefsey and become harder to treat.\nStore Odefsey in its original container at room temperature (below 86 °F (30 °C)). Keep away from moisture and heat. Keep the container tightly closed.\n Detailed Odefsey dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Be sure to take the medicine with a meal. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Odefsey can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, and some pain or arthritis medicines (including Advil, Motrin, and Aleve).\nMany drugs can interact with emtricitabine, rilpivirine, and tenofovir, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Odefsey. Give a list of all your medicines to any healthcare provider who treats you.\n Odefsey drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Odefsey: hives, blistering skin rash with fever; mouth sores, eye redness; difficulty breathing; swelling of your face, lips, tongue, or throat.\nSome people develop lactic acidosis while taking HIV medication. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.\nCall your doctor at once if you have:\nconfusion, severe depression, unusual thoughts or behavior, suicidal thoughts or actions;\nincreased thirst and urination, loss of appetite, weakness, constipation;\nkidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;\nliver problems - swelling around your midsection, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or\nsigns of inflammation in your body - swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing;\nOdefsey may increase your risk of certain infections or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment. Tell your doctor if you have:\nsigns of a new infection - fever, night sweats, swollen glands, diarrhea, weight loss;\nchest pain (especially when you breathe), dry cough, wheezing;\ncold sores, sores on your genital or anal area;\nfeeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;\ntrouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or\nswelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.\nCommon Odefsey side effects may include:\nheadache, dizziness, tiredness;\ndepressed mood, sleep problems (insomnia), strange dreams;\nrash;\nnausea, diarrhea; or\nchanges in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Odefsey side effects (more detail)\n','Odefsey contains a combination of emtricitabine, rilpivirine, and tenofovir. Emtricitabine, rilpivirine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body. HIV-1 is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).\nOdefsey is a prescription medicine that is used to treat Human Immunodeficiency Virus-1 (HIV-1) in people who have never taken HIV medicines before. This medicine is not a cure for HIV or AIDS.\nOdefsey is for use in adults and children who are at least 12 years old.\nOdefsey should not be taken together with other antiviral medications to treat HIV or AIDS.\n','There are many other drugs that can make Odefsey less effective and should not be used at the same time. Tell your doctor about all your the medicines you use.\nOdefsey may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.\nIf you have hepatitis B you may develop liver symptoms after you stop taking Odefsey. Your doctor may want to check your liver function for several months after you stop using Odefsey.\nBefore taking Odefsey\nYou should not take Odefsey if you are allergic to emtricitabine, rilpivirine, or tenofovir.\nDo not take Odefsey with other medicines that also contain emtricitabine, rilpivirine, tenofovir, adefovir, or lamivudine.\nThere are many other drugs that can make rilpivirine less effective and should not be used at the same time:\ndexamethasone;\nSt. John\'s wort;\ntuberculosis medication - rifabutin, rifampin, rifapentine;\nseizure medicine - carbamazepine, oxcarbazepine, phenobarbital, phenytoin; or\nstomach acid reducers - dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole.\nTo make sure Odefsey is safe for you, tell your doctor if you have ever had:\nkidney disease;\nliver disease (including hepatitis B or C);\ndepression or mental illness; or\nlong QT syndrome (in you or a family member)./p>\nSome people taking tenofovir develop a serious condition called lactic acidosis. This may be more likely in women, in people who are overweight or have liver disease, and in people who have taken HIV/AIDS medication for a long time. Talk with your doctor about your risk.\nHIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Tell your doctor if you become pregnant during treatment. If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of the medicine on the baby.\nWomen with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.\nOdefsey is not approved for use by anyone younger than 12 years old or weighing less than 77 pounds (35 kilograms).\n','Taking Odefsey will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.\nIf you also take an antacid, take it at least 2 hours before or 4 hours after taking Odefsey. If you also take a heartburn or GERD medicine (such as Tagamet, Pepcid, Zantac), take it at least 12 hours before or 4 hours after taking Odefsey.\n'),(625,'ofev','Usual Adult Dose for Idiopathic Pulmonary Fibrosis:\n150 mg orally every 12 hours\nMaximum dose: 300 mg/day\nComments:\n-Conduct liver function tests prior to initiating therapy.\n-Conduct a pregnancy test in females of reproductive potential prior to initiating therapy.\nUses:\n-For the treatment of idiopathic pulmonary fibrosis (IPF)\n-To slow the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD)\nUsual Adult Dose for Chronic Lung Disease:\n150 mg orally every 12 hours\nMaximum dose: 300 mg/day\nComments:\n-Conduct liver function tests prior to initiating therapy.\n-Conduct a pregnancy test in females of reproductive potential prior to initiating therapy.\nUses:\n-For the treatment of idiopathic pulmonary fibrosis (IPF)\n-To slow the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD)\n Detailed Ofev dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose at the regular time. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nDo not take more than 300 milligrams of nintedanib in one day.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may interact with nintedanib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Ofev drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Ofev: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere ongoing nausea, vomiting, or diarrhea;\nsevere stomach pain, bloating, or tenderness;\nbleeding from your rectum or blood in your stools;\neasy bruising or bleeding, any wound that will not heal;\nfever, chills, cough with mucus, chest pain, feeling short of breath;\nheart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;\nliver problems - stomach pain (upper right side), loss of appetite, tiredness, dark urine, jaundice (yellowing of the skin or eyes); or\nsigns of a stroke - sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance.\nLiver problems may be more likely in women, in people who weigh less than 143 pounds (65 kilograms), and in people of Asian descent.\nYour doses may be delayed if you have certain side effects.\nCommon Ofev side effects may include:\nnausea, vomiting, loss of appetite;\nstomach pain;\ndiarrhea, weight loss;\nincreased blood pressure;\nheadache; or\nabnormal liver function tests.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ofev side effects (more detail)\n','Ofev (nintedanib) is used in people with diseases that cause scar tissue (fibrosis) to form deep within the lungs. The scar tissue thickens and becomes stiff over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.\nOfev is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF).\nOfev is also used to treat chronic (long lasting) interstitial lung disease in which the scar tissue keeps getting worse.\nOfev is also used to slow the decline in lung function in people with a disorder called systemic sclerosis-associated interstitial lung disease (sometimes called scleroderma-associated ILD).\nOfev is not a cure for IPF or ILD, but this medicine can slow the effects of these diseases on your lungs.\n','Ofev can cause birth defects or death in an unborn baby. Avoid getting pregnant while you are using this medicine and for at least 3 months after your last dose. Use effective birth control, with an extra barrier method (condom, diaphragm, cervical cap, contraceptive sponge).\nBefore taking this medicine\nTo make sure Ofev is safe for you, tell your doctor if you have ever had:\nliver disease;\nheart problems;\na blood clot;\nbleeding problems (in you or a family member);\nsurgery on your stomach or intestines;\ndiverticulitis;\nif you smoke; or\nif you take a blood thinner such as warfarin (Coumadin, Jantoven).\nYou may need to have a negative pregnancy test before starting this treatment.\nNintedanib can cause birth defects or death in an unborn a baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose. Tell your doctor if you become pregnant.\nIf you use hormonal birth control (birth control pills, injections, implants, skin patches, or vaginal rings), also use a barrier form of birth control to prevent pregnancy while taking Ofev. Barrier forms include a condom, diaphragm, cervical cap, or contraceptive sponge).\nOfev may affect fertility (your ability to have children) in women. However, it is important to use birth control to prevent pregnancy because this medicine can harm an unborn baby.\nYou should not breastfeed while using this medicine.\nOfev is not approved for use by anyone younger than 18 years old.\nHow should I take Ofev?\nOfev is usually taken 2 times per day, every 12 hours. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nYour doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Ofev.\nTake with food and a full glass of water.\nSwallow the capsule whole and do not crush, chew, break, or open it.\nTake your doses at regular intervals, usually every 12 hours.\nOfev can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may need to take medication to prevent or quickly treat diarrhea.\nYour doctor may recommend you have an anti-diarrhea medicine such as loperamide (Imodium) available at all times while you are taking Ofev. Take the anti-diarrhea medicine as directed on the label, or as prescribed by your doctor.\nDrink plenty of liquids and call your doctor at once if you have diarrhea while taking Ofev.\nYou will need frequent medical tests to be sure nintedanib is not causing harmful effects on your liver. Your next few doses may be delayed based on the results.\nStore this medicine in the original container at room temperature, away from moisture and heat.\n','Smoking can make Ofev less effective. Avoid smoking while taking this medicine, or try to quit before you start this treatment.\nAvoid taking an herbal supplement containing St. John\'s wort.\nAsk your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with nintedanib may cause you to bruise or bleed easily.\n'),(626,'ofloxacin','Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nTake ofloxacin with water, and drink extra fluids to keep your kidneys working properly.\nYou may take ofloxacin with or without food, at the same time each day.\nUse  ofloxacin for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ofloxacin will not treat a viral infection such as the flu or a common cold.\nDo not share ofloxacin with another person.\nThis medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use ofloxacin.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\n Detailed Ofloxacin dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Some medicines can make ofloxacin much less effective when taken at the same time. If you take any of the following medicines, take your ofloxacin dose 2 hours before or 2 hours after you take the other medicine.\nantacids that contain calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate);\ndidanosine (Videx) powder or chewable tablets; or\nvitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.\nTell your doctor about all your other medicines, especially:\ntheophylline;\na blood thinner (warfarin, Coumadin, Jantoven);\na diuretic or \"water pill\";\ninsulin or oral diabetes medicine (check your blood sugar regularly);\nheart rhythm medication;\nmedicine to treat depression or mental illness;\nsteroid medicine (such as prednisone); or\nNSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.\nThis list is not complete. Other drugs may affect ofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Ofloxacin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).\nOfloxacin can cause serious side effects, including tendon problems, side effects on your nerves (which may cause permanent nerve damage), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).\nStop taking this medicine and call your doctor at once if you have:\nlow blood sugar--headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, or feeling anxious or shaky;\nnerve symptoms in your hands, arms, legs, or feet--numbness, weakness, tingling, burning pain;\nserious mood or behavior changes--nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or\nsigns of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).\nIn rare cases, ofloxacin may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.\nAlso, stop using ofloxacin and call your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\nfast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);\nthe first sign of any skin rash, no matter how mild;\nmuscle weakness, breathing problems;\nlittle or no urination;\na seizure (convulsions);\nincreased pressure inside the skull--severe headaches, ringing in your ears, vision problems, pain behind your eyes; or\nliver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nCommon side effects may include:\nnausea, constipation, diarrhea;\ndizziness; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ofloxacin side effects (more detail)\n','Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body.\nOfloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract (bladder and kidneys). Ofloxacin is also used to treat pelvic inflammatory disease and Chlamydia and/or gonorrhea.\nFluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible. Ofloxacin should be used only for infections that cannot be treated with a safer antibiotic.\nOfloxacin may also be used for purposes not listed in this medication guide.\n','Ofloxacin can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar.\nStop using  ofloxacin and call your doctor at once if you have symptoms such as: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.\nIn rare cases, ofloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to ofloxacin or other fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, and others).\nOfloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles\' tendon of the heel. This can happen during treatment or up to several months after you stop taking ofloxacin. Tendon problems may be more likely in certain people (children and older adults, or people who use steroid medicine or have had an organ transplant).\nTell your doctor if you have ever had:\ntendon problems, bone problems, arthritis, or other joint problems;\nblood circulation problems, aneurysm, narrowing or hardening of the arteries;\nheart problems, high blood pressure;\na genetic disease such as Marfan syndrome or Ehler\'s-Danlos syndrome;\ndiabetes;\na muscle or nerve disorder, such as myasthenia gravis;\nliver or kidney disease;\na seizure;\nlong QT syndrome (in you or a family member); or\nlow levels of potassium in your blood (hypokalemia).\nOfloxacin is not approved for use by anyone younger than 18 years old.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.\nYou should not breast-feed while using this medicine.\n','Avoid driving or hazardous activity until you know how  ofloxacin will affect you. Your reactions could be impaired.\nAntibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\nOfloxacin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.\n'),(627,'olanzapine','Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nOlanzapine can be taken with or without food.\nRemove an orally disintegrating tablet (Zyprexa Zydis) from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.\nOlanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis.\nYou may gain weight or have high cholesterol and triglycerides (types of fat) while taking  olanzapine, especially if you are a teenager. You may need frequent blood tests.\nCall your doctor if your symptoms do not improve, or if they get worse while using olanzapine.\nDo not stop using olanzapine suddenly, even if you feel fine. Stopping suddenly may cause serious side effects.\nOlanzapine is sometimes used together with other antipsychotic medications or antidepressants. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor\'s advice.\nMedication may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor\'s instructions.\nStore at room temperature away from moisture, heat, and light.\n Detailed Olanzapine dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include drowsiness, agitation, aggression, slurred speech, confusion, increased heart rate, jerky or uncontrolled muscle movements, trouble breathing, or fainting.\n','Taking olanzapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nOther drugs may affect olanzapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Olanzapine drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSeek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.\nHigh doses or long-term use of olanzapine can cause a serious movement disorder that may not be reversible. The longer you use olanzapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.\nCall your doctor at once if you have:\nuncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);\ntrouble speaking or swallowing;\nswelling in your hands or feet;\nconfusion, unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself;\nlow white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or\nsigns of dehydration--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;\nliver problems--upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nhigh blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or\nsevere nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.\nCommon side effects may include:\nweight gain (more likely in teenagers), increased appetite;\nheadache, dizziness, drowsiness, feeling tired or restless;\nproblems with speech or memory;\ntremors or shaking, numbness or tingly feeling;\nchanges in personality;\ndry mouth, or increased salivation;\nstomach pain, constipation; or\npain in your arms or legs.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Olanzapine side effects (more detail)\n','Olanzapine is an antipsychotic medication that is used to treat psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children at least 13 years old.\nOlanzapine is also used together with fluoxetine (Prozac) to treat episodes of depression in adults and children at least 10 years old who have bipolar I disorder.\nOlanzapine may also be used for purposes not listed in this medication guide.\n','Olanzapine is not approved for use in older adults with dementia-related psychosis.\nBefore taking this medicine\nYou should not take olanzapine if you are allergic to it.\nOlanzapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.\nTell your doctor if you have ever had:\nliver disease;\nheart disease, high or low blood pressure;\nhigh cholesterol or triglycerides;\na stroke, including \"mini-stroke\";\nbreast cancer;\na seizure;\nAlzheimer\'s disease;\ndiabetes or high blood sugar;\nan enlarged prostate;\nbowel problems; or\nnarrow-angle glaucoma.\nTaking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking olanzapine without your doctor\'s advice.\nOlanzapine can pass into breast milk. If you are breastfeeding, tell your doctor if you notice severe drowsiness, irritability, feeding problems, tremors, or unusual muscle movements in the nursing baby.\nThe olanzapine orally disintegrating tablet (Zyprexa Zydis) may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).\n','Avoid driving or hazardous activity until you know how  olanzapine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nAvoid drinking alcohol. Dangerous side effects could occur.\nAvoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine.\n'),(628,'olaparib','Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nTake your doses at regular intervals, about 12 hours apart. You may take olaparib with or without food.\nSwallow the tablet whole and do not crush, chew, or break it.\nOlaparib affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.\nYou may also need chest x-rays to be sure this medicine is not causing harmful effects on your lungs. Your cancer treatments may be delayed based on the results.\nStore at room temperature away from moisture and heat.\n Detailed Olaparib dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose at the regular time. Do not use two doses at one time.\nDo not take more than 4 olaparib tablets in one day.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may affect olaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Olaparib drug interactions (more detail)\nDoes Olaparib interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nYou may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:\nfever, chills, weakness, feeling light-headed or very tired;\nmouth sores, skin sores;\neasy bruising, unusual bleeding;\npain or burning when you urinate, blood in your urine or stools;\npale skin, cold hands and feet\nweight loss; or\ncough, wheezing, shortness of breath.\nYour cancer treatments may be delayed if you have certain side effects.\nSome people who take olaparib with a gonadotropin-releasing hormone (GnRH) medicine may develop a blood clot in the leg or in the lung. Call your doctor if you have pain or swelling in your arm or leg, shortness of breath, chest pain, rapid breathing, or fast heartbeats.\nCommon side effects may include:\nlow blood cell counts;\npain and burning when you urinate, painful urination;\nnausea, vomiting, upper stomach pain, diarrhea;\nheartburn, indigestion, loss of appetite;\ndizziness, feeling weak or tired;\nheadache;\ncough, shortness of breath; or\naltered sense of taste.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Olaparib side effects (more detail)\n','Olaparib is used to treat cancers of the breast, ovary, fallopian tube, pancreas, prostate, or peritoneum (the membrane that lines the inside of your abdomen and covers some of your internal organs).\nOlaparib is sometimes used when the cancer has spread to other parts of the body, or when cancer has come back after treatment with other medications.\nOlaparib is sometimes used only if your cancer has a specific genetic marker (an abnormal \"BRCA\" or \"HRR\" gene). Your doctor will test you for this gene.\nOlaparib may also be used for purposes not listed in this medication guide.\n','Olaparib affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, weakness, tiredness, trouble breathing, easy bruising or bleeding, blood in your urine or stools, or weight loss.\nYou will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.\nSome people who take olaparib with a gonadotropin-releasing hormone (GnRH) medicine may develop a blood clot in the leg or in the lung. Call your doctor if you have pain or swelling in your arm or leg, shortness of breath, chest pain, rapid breathing, or fast heartbeats.\nOlaparib may also cause serious lung problems. Call your doctor if you have chest pain, wheezing, trouble breathing, or a new or worsening cough.\nBefore taking this medicine\nTell your doctor if you have ever had:\nlung disease, breathing problems; or\nkidney disease.\nOlaparib can harm an unborn baby or cause a miscarriage if the mother or the father is using  olaparib.\nIf you are a woman, do not use this medicine if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.\nIf you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Also do not to donate sperm during the 3 months after your last dose.\nTell your doctor right away if a pregnancy occurs while either the mother or the father is using olaparib.\nDo not breastfeed while using this medicine, and for at least 1 month after your last dose.\n','Grapefruit and Seville oranges may interact with olaparib and lead to unwanted side effects. Avoid the use of grapefruit products and orange marmalades.\n'),(629,'olmesartan','Usual Adult Dose for Hypertension:\n20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed.Maximum dose: 40 mg orally once a dayComments:-For patients with possible intravascular volume depletion (e.g., patients treated with diuretics, especially those with impaired renal function), initiate this drug under close supervision and give consideration to a lower starting dose.-Twice daily dosing offers no additional benefit over the same total dose give once daily.\nUsual Pediatric Dose for Hypertension:\n6 to 16 years:-20 to less than 35 kg: 10 mg orally once a day; may increase dose to 20 mg in two weeks if further blood pressure reduction is needed-35 kg or more: 20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is neededComments:-For children who cannot swallow tablets, the same dose can be given using an extemporaneous suspension.\n Detailed Olmesartan dosage information\n','If you take colesevelam, take your olmesartan dose 4 hours before you take colesevelam.\nTell your doctor about all your other medicines, especially:\nlithium;\na diuretic (water pill) or other medicines that lower blood pressure; or\nNSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.\nThis list is not complete. Other drugs may affect olmesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Olmesartan drug interactions (more detail)\nDoes Olmesartan interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nlittle or no urination;\nsevere diarrhea and weight loss; or\nhigh potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.\nCommon side effects may include:\ndizziness.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Olmesartan side effects (more detail)\n','Olmesartan is an angiotensin II receptor blocker (sometimes called an ARB).\nOlmesartan is used to treat high blood pressure (hypertension) in adults and children at least 6 years old. It is sometimes given together with other blood pressure medications.\nOlmesartan may also be used for purposes not listed in this medication guide.\n','Do not use if you are pregnant. Stop using olmesartan and tell your doctor right away if you become pregnant.\nIf you have diabetes, do not take olmesartan with any medication that contains aliskiren (a blood pressure medicine).\nBefore taking this medicine\nYou should not take olmesartan if you are allergic to it.\nIf you have diabetes, do not use olmesartan together with any medication that contains aliskiren (a blood pressure medicine).\nYou may also need to avoid taking olmesartan with aliskiren if you have kidney disease.\nTell your doctor if you have ever had:\na heart condition other than one being treated with olmesartan;\nkidney disease; or\nif you are on a low salt diet.\nDo not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.\nIf you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby.\nYou should not breastfeed while using  olmesartan.\nHow should I take olmesartan?\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nYou may take olmesartan with or without food.\nFor a child who cannot swallow a tablet whole, a pharmacist can mix the medicine into a liquid.\nShake the liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nOlmesartan doses are based on weight in children and/or teenagers. Your child\'s dose needs may change if the child gains or loses weight.\nCall your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking olmesartan.\nIt may take up to 2 weeks before your blood pressure is under control. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms.\nYou may need to use blood pressure medicine for the rest of your life. Treatment may also include diet, exercise, lowering cholesterol, not smoking, and controlling diabetes.\nYour blood pressure will need to be checked often. Your kidney function may also need to be checked.\nStore tablets at room temperature away from moisture and heat.\nStore the liquid in a refrigerator. Throw away any liquid leftover after 4 weeks.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include fast heartbeats or fainting.\n','Do not use potassium supplements or salt substitutes, unless your doctor has told you to.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy.\n'),(630,'olopatadine','Administration\nAdminister intranasally or topically to the eye.\nIntranasal Administration\nAdminister intranasally twice daily, using a metered-dose nasal spray pump. Avoid spraying into the eyes.\nBefore initial use, prime the pump by releasing 5 sprays or until a fine mist appears. If nasal spray has not been used for >7 days, reprime the pump by releasing 2 sprays.\nTo actuate the pump, hold the bottle in one hand; with forefinger and middle finger on the shoulders of the pump unit and the thumb on the bottom of the bottle, press down on the shoulders of the pump to produce a fine mist.\nPrior to administration, gently blow the nose to clear nasal passages. To administer, close one nostril; then, with head tipped down (chin toward chest), insert nasal applicator ¼ to ½ inch into the other nostril, hold bottle vertically upright, and aim spray tip toward the cheek side of the nose (away from the center of the nose). While gently breathing in through the nose, press firmly and quickly on the pump to release the spray. Breathe out through the mouth.\nDo not tip head back or blow the nose immediately after dosing; tipping head back may produce a bitter taste in the mouth.\nRepeat procedure for the other nostril. Alternate nostrils between each actuation.\nFollowing administration, wipe nasal applicator with a clean tissue and replace the blue plastic cap.\nIf nasal applicator becomes clogged, do not attempt to clean by inserting a sharp object. Instead, remove nasal applicator by gently pulling it upward; once removed, wash (while pointing nasal applicator downward) by running warm tap water for about one minute. Shake the applicator to remove any water and place the applicator back on the bottle. Prime by spraying 2 times or until a fine mist appears.\nDiscard after 240 sprays.\nOphthalmic Administration\nApply topically to the eye as an ophthalmic solution. Not for injection or oral use.\nIf more than one topical ophthalmic drug is used, administer the drugs at least 5 minutes apart.\nAvoid contamination of the solution container.\nDosage\nAvailable as olopatadine hydrochloride; dosage expressed in terms of olopatadine.\nNasal spray delivers about 665 mcg of olopatadine hydrochloride (equivalent to 600 mcg of olopatadine) per metered spray and about 240 metered sprays per 30.5-g bottle.\nPediatric Patients\nAllergic Conjunctivitis\nOphthalmic\n0.1% ophthalmic solution: In children ≥3 years of age, 1 drop in the affected eye(s) twice daily (at an interval of 6–8 hours).\n0.2% ophthalmic solution: In children ≥2 years of age, 1 drop in the affected eye(s) once daily.\nOnce symptomatic improvement is established, continue therapy for as long as necessary to sustain improvement.\nSeasonal Allergic Rhinitis\nIntranasal\nChildren 6–11 years of age: 1 spray (600 mcg) in each nostril twice daily.\nChildren ≥12 years of age: 2 sprays (1200 mcg) in each nostril twice daily.\nAdults\nAllergic Conjunctivitis\nOphthalmic\n0.1% ophthalmic solution: 1 drop in the affected eye(s) twice daily (at an interval of 6–8 hours).\n0.2% ophthalmic solution: 1 drop in the affected eye(s) once daily.\nOnce symptomatic improvement is established, continue therapy for as long as necessary to sustain improvement.\nSeasonal Allergic Rhinitis\nIntranasal\n2 sprays (1200 mcg) in each nostril twice daily.\nSpecial Populations\nHepatic Impairment\nNasal spray: Dosage adjustment not necessary.\nHepatic Impairment\nNasal spray: Dosage adjustment not necessary.\nGeriatric Patients\nNasal spray: Select dosage with caution. (See Geriatric Use under Cautions.)\n Detailed Olopatadine ophthalmic dosage information\n','No formal drug interaction studies involving ophthalmic solution or nasal spray to date. \nDoes not inhibit in vitro metabolism of substrates of CYP isoenzymes 1A2, 2C9, 2C19, 2D6, 2E1, or 3A4.\nDrugs Affecting or Metabolized by Hepatic Enzymes\nInteractions with drugs that inhibit hepatic enzymes (e.g., CYP microsomal enzymes) unlikely because olopatadine is eliminated predominantly by renal excretion.\nPotential for olopatadine and its metabolites to act as inducers of CYP isoenzymes not evaluated.\nProtein-bound Drugs\nInteractions with protein-bound drugs (e.g., possible displacement of other protein-bound drugs) unlikely because olopatadine is modestly protein bound.\nSpecific Drugs\nDrug\nInteraction\nComments\nCNS depressants (e.g., alcohol)\nPossible additive CNS depression when used concomitantly with nasal spray\nAvoid concomitant use with nasal spray\n',NULL,'Allergic Conjunctivitis\nUsed ophthalmically for symptomatic management of ocular itching associated with allergic conjunctivitis.   \nSeasonal Allergic Rhinitis\nUsed intranasally to provide symptomatic relief of seasonal allergic rhinitis (e.g., hay fever).\nProvides symptomatic relief of nasal congestion, rhinorrhea, nasal itching, and sneezing.\n',NULL,NULL),(631,'olopatadine-nasal','Usual Adult Dose for Allergic Rhinitis:\n2 sprays in each nostril twice a dayUse: For the relief of symptoms of seasonal allergic rhinitis\nUsual Pediatric Dose for Allergic Rhinitis:\n6 to 11 years: 1 spray in each nostril twice a day12 years or older: 2 sprays in each nostril twice a dayUse: For the relief of symptoms of seasonal allergic rhinitis\n Detailed Olopatadine nasal dosage information\n','Before using olopatadine nasal, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by olopatadine nasal.\nThere may be other drugs that can interact with olopatadine nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.\n Olopatadine nasal drug interactions (more detail)\nDoes Olopatadine nasal interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using olopatadine nasal and call your doctor at once if you have a serious side effect such as:\nnosebleed;\nsores inside your nose;\nfever; or\nburning or pain when you urinate.\nLess serious side effects may include:\ndrowsiness;\na bitter taste in your mouth;\nheadache;\ndry mouth, sore throat;\ncough, sneezing, runny nose, cold symptoms;\nweight gain; or\nnausea, diarrhea, stomach pain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Olopatadine nasal side effects (more detail)\n','Olopatadine nasal is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.\nOlopatadine nasal (for the nose) is used to treat symptoms such as congestion, sneezing, and runny nose caused by seasonal allergies. Olopatadine nasal is for use in adults and children who are at least 6 years old.\nOlopatadine nasal may also be used for purposes not listed in this medication guide.\n','Before using olopatadine nasal, tell your doctor if you have any non-allergic conditions affecting the inside of your nose, such as a deviated septum.\nThis medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDrinking alcohol can increase certain side effects of olopatadine nasal.\nCall your doctor if your symptoms do not improve, or if they get worse while using olopatadine nasal.\nBefore taking this medicine\nYou should not use this medication if you are allergic to olopatadine.\nBefore using olopatadine nasal, tell your doctor if you have any non-allergic conditions affecting the inside of your nose, such as a deviated septum.\nFDA pregnancy category C. It is not known whether olopatadine nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.\nIt is not known whether olopatadine nasal passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.\nDo not give  olopatadine to a child younger than 6 years old without medical advice.\nHow should I use olopatadine nasal?\nUse exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.\nBefore using the spray for the first time, you must prime the spray pump. Shake the medicine well and spray 5 test sprays into the air and away from your face. Spray until a fine mist appears.\nTo use the olopatadine nasal spray:\nGently blow your nose before using the nasal spray.\nInsert the spray tip into your nostril, pointing it straight up into your nose. Press your other nostril closed with your finger and keep your head upright. Pump the spray and gently inhale at the same time.\nUse only the number of sprays prescribed by your doctor.\nClean the pump nozzle with a clean, damp tissue and recap it.\nPrime the spray pump with at least 2 sprays any time it has been longer than 7 days since you last used it.\nTry not to sneeze or blow your nose just after using the spray.\nCall your doctor if your symptoms do not improve, or if they get worse while using olopatadine nasal.\nStore at room temperature away from moisture and heat.\nWhat happens if I miss a dose?\nUse the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include severe forms of some of the side effects listed in this medication guide.\n','This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDrinking alcohol can increase certain side effects of olopatadine nasal.\nAvoid getting this medication in your eyes. If this does happen, rinse with water.\n'),(632,'olopatadine-ophthalmic','Usual Adult Dose for Seasonal Allergic Conjunctivitis:\n0.1% solution: 1 drop in each affected eye twice per day at an interval of 6 to 8 hours0.2%/0.7% solution: 1 drop in each affected eye once a dayUse: Treatment of the signs and symptoms of allergic conjunctivitis\nUsual Pediatric Dose for Seasonal Allergic Conjunctivitis:\n2 years or older:0.2%/0.7% solution: 1 drop in each affected eye once a day3 years or older:0.1% solution: 1 drop in each affected eye twice per day at an interval of 6 to 8 hoursUse: Treatment of the signs and symptoms of allergic conjunctivitis\n Detailed Olopatadine ophthalmic dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\n','Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nStop using this medicine and call your doctor at once if you have:\neye pain or changes in vision;\neye itching that gets worse or lasts longer than 72 hours;\nsevere burning, stinging, or irritation after using this medicine; or\neye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection).\nLess serious side effects may be more likely, and you may have none at all.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Olopatadine ophthalmic side effects (more detail)\n','Olopatadine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of itching or watery eyes.\nOlopatadine ophthalmic (for the eye) is used to treat eye itching caused by allergies.\nOlopatadine ophthalmic may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use olopatadine ophthalmic if you are allergic to it.\nAsk a doctor or pharmacist if  olopatadine ophthalmic is safe to use if you have any type of eye infection.\nTell your doctor if you are pregnant or breastfeeding.\nOlopatadine ophthalmic is not approved for use by anyone younger than 2 years old.\nHow should I use olopatadine ophthalmic?\nUse exactly as directed on the label, or as prescribed by your doctor.\nDo not use while wearing soft contact lenses. A preservative in this medicine could permanently stain the lenses. Use the medicine at least 15 minutes before inserting your contact lenses.\nWash your hands before using eye medication.\nTo apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye and squeeze a drop into this pocket. Close your eyes for 1 or 2 minutes.\nWait at least 10 minutes before using any other eye drops your doctor has prescribed.\nUse only the number of drops recommended on the medicine label.\nDo not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.\nDo not use the eye drops if the liquid looks cloudy or has changed colors.\nStore at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nAn overdose of olopatadine ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\n','Avoid wearing contact lenses while your eyes are red or irritated.  olopatadine ophthalmic will not treat eye irritation caused by wearing contacts.\n'),(633,'olux','Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nDo not take by mouth. Topical medicine is for use only on the skin. Rinse with water if this medicine gets in your eyes or mouth.\nDo not use Olux on broken or infected skin. Also avoid using this medicine in open wounds.\nWash your hands before and after using clobetasol, unless you are using the medicine to treat the skin on your hands.\nApply a thin layer of medicine to the affected skin and rub it in gently. Do not apply this medicine over a large area of skin unless your doctor has told you to.\nDo not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.\nIf you are treating the diaper area, do not use plastic pants or tight-fitting diapers.\nThis medicine is for short-term use only (2 weeks, or up to 4 weeks for scalp psoriasis). Follow your doctor\'s dosing instructions very carefully.\nIf you use clobetasol to treat plaque psoriasis, you should stop using the medicine once your skin symptoms are controlled.\nCall your doctor if your symptoms do not improve, or if they get worse.\nYou should not stop using clobetasol suddenly. Follow your doctor\'s instructions about tapering your dose.\nStore at room temperature away from moisture and heat. Keep from freezing.\nClobetasol foam is flammable. Do not use near high heat or open flame. Do not smoke until the foam has completely dried on your skin.\n Detailed Olux dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nApply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\nHigh doses or long-term use of  Olux can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.\n','Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.\n Olux drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nworsening of your skin condition;\nredness, warmth, swelling, oozing, or severe irritation of any treated skin;\nblurred vision, tunnel vision, eye pain, or seeing halos around lights;\nhigh blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or\npossible signs of absorbing this medicine through your skin--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes.\nCommon side effects may include:\nburning, itching, swelling, or irritation of treated skin;\ndry or cracking skin;\nredness or crusting around your hair follicles;\nspider veins;\nstretch marks, thinning skin;\nrash or hives;\nacne; or\ntemporary hair loss.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Olux side effects (more detail)\n','Clobetasol is a highly potent steroid that helps reduce inflammation in the body.\nOlux (for the skin) is used to treat inflammation and itching caused by plaque psoriasis or skin conditions that respond to steroid medication.\nOlux may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use Olux if you are allergic to it.\nTell your doctor if you have ever had:\nany type of skin infection;\na skin reaction to any steroid medicine;\nliver disease; or\nan adrenal gland disorder.\nSteroid medicines can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.\nIt is not known whether  Olux will harm an unborn baby. Tell your doctor if you are pregnant.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. If you apply clobetasol to your chest, avoid areas that may come into contact with the baby\'s mouth.\nOlux is not approved for use by anyone younger than 12 years old. Some brands or forms of this medicine are for use only in adults 18 and over.\nChildren can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.\n','Avoid applying  Olux to your face, underarms, or groin area.\nDo not use this medicine to treat any condition that has not been checked by your doctor.\nAvoid using other topical steroid medications on the areas you treat with clobetasol unless your doctor tells you to.\n'),(634,'omalizumab','Your doctor may perform an allergy skin test or blood test to make sure this medicine is right for you.\nOmalizumab is injected under the skin. A healthcare provider will give you this injection every 2 or 4 weeks.\nYour condition may not improve right away. For best results, keep receiving omalizumab as directed. Talk with your doctor if your symptoms do not improve after a few weeks of treatment.\nOmalizumab doses are based on weight. Your dose needs may change if you gain or lose weight.\nIf you also use a steroid medication, you should not stop using it suddenly. Follow your doctor\'s instructions about tapering your dose.\nSeek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.\nYou may need frequent medical tests, such as allergy tests and lung function tests. Your stools may also need to be checked for parasites, especially if you travel.\n Detailed Omalizumab dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss an appointment for your omalizumab injection.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may affect omalizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Omalizumab drug interactions (more detail)\n','Some people using omalizumab have had a severe, life-threatening allergic reaction either right after the injection or hours later. Allergic reaction may occur even after using the medication regularly for a year or longer.\nYou will be watched closely for a short time after each injection, to make sure you do not have an allergic reaction to omalizumab.\nGet emergency medical help if you have signs of an allergic reaction:\nhives, itching;\nanxiety or fear, feeling like you might pass out;\nflushing (warmth, redness, or tingly feeling);\nchest tightness, wheezing, cough, feeling short of breath, difficult breathing;\nfast or weak heartbeats; or\nswelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nongoing nausea or vomiting, severe or watery diarrhea;\ntrouble breathing;\nnumbness or tingling in your arms or legs;\nfever, muscle pain, and rash within a few days after receiving an injection;\nsigns of an ear infection--fever, ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child;\nheart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder; or\nsigns of a blood clot--sudden numbness or weakness, problems with vision or speech, coughing up blood, swelling or redness in an arm or leg.\nCommon side effects may include:\nrash;\nfever;\nnosebleeds;\njoint pain, bone fractures;\narm or leg pain;\nnausea, vomiting, diarrhea, stomach pain;\nheadache;\ndizziness, feeling tired;\near pain, ear infection;\npain, bruising, swelling, or irritation where the medicine was injected; or\ncold symptoms such as stuffy nose, sneezing, sinus pain, cough, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Omalizumab side effects (more detail)\n','Omalizumab is used to treat moderate to severe asthma that is caused by allergies in adults and children who are at least 6 years old. Omalizumab is used when asthma symptoms are not controlled by asthma inhaled steroid medicine. Omalizumab is not a rescue medicine for treating an asthma attack.\nOmalizumab is used to treat nasal polyps in adults when nasal steroid medicine did not work.\nOmalizumab is also used to treat chronic hives (idiopathic urticaria) in adults and children at lest 12 years old, when antihistamines have not worked.\nOmalizumab is not for use in treating other allergies, rashes, or attacks of bronchospasm.\nOmalizumab may also be used for purposes not listed in this medication guide.\n','Some people using omalizumab have had a severe, life-threatening allergic reaction either right after the injection or hours later. An allergic reaction may occur even after using omalizumab regularly for a year or longer.\nGet emergency medical help if you have signs of an allergic reaction: hives, itching; anxiety or fear; flushing (warmth, redness, or tingly feeling); feeling like you might pass out; chest tightness, wheezing, cough, feeling short of breath, difficult breathing; fast or weak heartbeats; swelling of your face, lips, tongue, or throat.\nBefore taking this medicine\nYou should not use omalizumab if you are allergic to it.\nTell your doctor if you have any signs of infection (fever, swollen glands, general ill feeling), or if you have ever had:\nany other allergies (foods, pollens, etc);\nallergy shots;\na severe allergic reaction (anaphylaxis);\nan infection caused by parasites (such as giardia, malaria, leishmaniasis, hookworm, pinworm, toxoplasmosis, and many others);\na heart attack or stroke;\ncancer; or\na latex allergy.\nUsing  omalizumab may increase your risk of certain types of cancers of the breast, skin, prostate, or salivary gland. Talk to your doctor about your individual risk.\nWhile you are using omalizumab, you may also have an increased risk of becoming infected with parasites (worms) if you live in or travel to areas where such infections are common. Talk with your doctor about what to look for and how to treat this condition.\nSome babies born to mothers using omalizumab during pregnancy had low birth weight. However, it is not known whether this was due to omalizumab use or to severe asthma in the mothers. The benefit of treating asthma may outweigh any risks to the baby. Tell your doctor if you are pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of omalizumab on the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(635,'omega-3-polyunsaturated-fatty-acids','Usual Adult Dose for Hypertriglyceridemia:\n1 gram prescription only products:4 grams orally daily; may be given as a single dose or 2 divided doses.Comments:-Assess triglyceride levels carefully before starting therapy and identify other possible causes (e.g.  diabetes, hypothyroidism, medications) and manage appropriately.-Patients should be on a lipid lowering diet prior to using this medication, and continue the diet during use of this medication.-Capsules should be swallowed whole; do not break, crush, chew or dissolve capsules.-In clinical trials, the medication was administered with meals.\n Detailed Omega-3 polyunsaturated fatty acids dosage information\n','Tell your doctor about all your other medicines, especially:\na blood thinner--warfarin, Coumadin, Jantoven.\nThis list is not complete. Other drugs may affect omega-3 polyunsaturated fatty acids, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Omega-3 polyunsaturated fatty acids drug interactions (more detail)\nDoes Omega-3 polyunsaturated fatty acids interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nchest pain; or\nuneven heartbeats.\nCommon side effects may include:\nloss of appetite;\ndiarrhea, constipation, upset stomach, belching;\nback pain; or\ndry mouth, altered sense of taste.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Omega-3 polyunsaturated fatty acids side effects (more detail)\n','There are many brands and forms of omega-3 polyunsaturated fatty acids available. Not all brands are listed on this leaflet.\nOmega-3 polyunsaturated fatty acids are used together with diet and exercise to help lower triglyceride levels in the blood.\nIt is not known if omega-3 polyunsaturated fatty acids will prevent a heart attack or stroke. Talk to your doctor about your risk factors.\nOmega-3 polyunsaturated fatty acids may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use  omega-3 polyunsaturated fatty acids if you are allergic to omega-3 polyunsaturated fatty acids or soybeans.\nTell your doctor if you have ever had:\nan allergy to fish or shellfish;\ndiabetes;\nliver disease;\na heart rhythm disorder;\na pancreas disorder; or\nunderactive thyroid.\nTell your doctor if you are pregnant or breastfeeding.\nOmega-3 polyunsaturated fatty acids is not approved for use by anyone younger than 18 years old.\nHow should I take omega-3 polyunsaturated fatty acids?\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nSwallow the capsule whole and do not crush, chew, break, or open it.\nTake with food.\nWhile using omega-3 polyunsaturated fatty acids, you may need frequent blood tests.\nYou may need to follow a special diet while using omega-3 polyunsaturated fatty acids. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.\nIf you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.\nStore at room temperature away from moisture and heat. Do not freeze.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Avoid eating foods high in fat or cholesterol, or omega-3 polyunsaturated fatty acids will not be as effective.\nAvoid drinking alcohol. It can increase triglycerides and may make your condition worse.\n'),(636,'omeprazole','Take omeprazole exactly as directed on the label, or as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nUse Prilosec OTC (over-the-counter) exactly as directed on the label, or as prescribed by your doctor.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nIf you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.\nYou must dissolve omeprazole powder in a small amount of water. This mixture can either be swallowed or given through a nasogastric (NG) feeding tube using a catheter-tipped syringe.\nUse this medicine for the full prescribed length of time, even if your symptoms quickly improve.\nOTC omeprazole should be taken for only 14 days in a row. It may take 1 to 4 days before your symptoms improve. Allow at least 4 months to pass before you start a new 14-day course of treatment.\nCall your doctor if your symptoms do not improve, or if they get worse.\nSome conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.\nStore at room temperature away from moisture and heat.\n Detailed Omeprazole dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nTell your doctor about all your current medicines. Many drugs can affect omeprazole, especially:\ndigoxin;\nclopidogrel;\nmethotrexate;\nSt. John\'s wort;\na diuretic or \"water pill\"; or\nan antibiotic - amoxicillin, clarithromycin, rifampin.\nThis list is not complete and many Other drugs may interact with omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Omeprazole drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to omeprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nStop using this medicine and call your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\nnew or unusual pain in your wrist, thigh, hip, or back;\nseizure (convulsions);\nkidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;\nlow magnesium - dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or\nnew or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.\nTaking omeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.\nIf you use omeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.\nCommon omeprazole side effects may include:\ncold symptoms such as stuffy nose, sneezing, sore throat (especially in children);\nfever (especially in children);\nstomach pain, gas;\nnausea, vomiting, diarrhea; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Omeprazole side effects (more detail)\n','Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.\nOmeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).\nOmeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with Helicobacter pylori (H. pylori).\nOver-the-counter (OTC) omeprazole is used in adults to help control heartburn that occurs 2 or more days per week.\nThe OTC brand of omeprazole must be taken as a course on a regular basis for 14 days in a row.\n','Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.\nDiarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.\nOmeprazole is not to used for the immediate relief of heartburn symptoms.\nOmeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.\nYou may be more likely to have a broken bone while taking this medicine long term or more than once per day.\nBefore taking this medicine\nHeartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel sweaty or light-headed.\nYou should not use omeprazole if you are allergic to it, or if:\nyou are also allergic to medicines like omeprazole, such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;\nyou had breathing problems, kidney problems, or a severe allergic reaction after taking omeprazole in the past; or\nyou also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).\nAsk a doctor or pharmacist if this medicine is safe to use if you have:\ntrouble or pain with swallowing;\nbloody or black stools, vomit that looks like blood or coffee grounds;\nheartburn that has lasted for over 3 months;\nfrequent chest pain, heartburn with wheezing;\nunexplained weight loss;\nnausea or vomiting, stomach pain;\nliver disease;\nlow levels of magnesium in your blood; or\nosteoporosis or low bone mineral density (osteopenia).\nYou may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.\nAsk a doctor before using this medicine if you are pregnant or breastfeeding.\nDo not give this medicine to a child without medical advice.\n','Omeprazole can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\n'),(637,'omnicef','Take Omnicef exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medicine guides or instruction sheets.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nYou may take this medicine with or without food.\nUse this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Cefdinir will not treat a viral infection such as the flu or a common cold.\nCefdinir can affect the results of certain medical tests. Tell any doctor who treats you that you are using cefdinir.\nStore at room temperature away from moisture and heat. Throw away any unused liquid medicine that is older than 10 days.\n Detailed Omnicef dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, vomiting, stomach pain, diarrhea, or a seizure.\n','Tell your doctor about all your other medicines, especially:\nprobenecid; or\nvitamin or mineral supplements that contain iron.\nThis list is not complete. Other drugs may interact with cefdinir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Omnicef drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Omnicef (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nCall your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);\nfever, chills, body aches, flu symptoms;\npale skin, easy bruising, unusual bleeding;\nseizure (convulsions);\nfever, weakness, confusion;\ndark colored urine, jaundice (yellowing of the skin or eyes); or\nkidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath.\nCommon Omnicef side effects may include:\nnausea, vomiting, stomach pain, diarrhea;\nvaginal itching or discharge;\nheadache; or\nrash (including diaper rash in an infant taking liquid cefdinir).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Omnicef side effects (more detail)\n','Omnicef (cefdinir) belongs to a group of drugs called cephalosporin (SEF a low spor in) antibiotics. Cefdinir works by fighting bacteria in your body.\nOmnicef is an antibiotic that is used to treat many different types of infections caused by bacteria.\n','Do not take Omnicef if you are allergic to cefdinir, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, and others.\nBefore taking Omnicef, tell your doctor if you are allergic to any drugs (especially penicillin). Also tell your doctor if you have kidney disease or a history of intestinal problems.\nTake Omnicef for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefdinir will not treat a viral infection such as the common cold or flu.\nAntibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking this medicine and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.\nBefore taking this medicine\nTo make sure Omnicef is safe for you, tell your doctor if you have ever had:\nkidney disease (or if you are on dialysis);\nintestinal problems, such as colitis; or\nan allergy to any drugs (especially penicillins).\nOmnicef liquid contains sucrose. Talk to your doctor before using this form of cefdinir if you have diabetes.\nTell your doctor if you are pregnant or breastfeeding.\n','Avoid using antacids or mineral supplements that contain aluminum, magnesium, or iron within 2 hours before or after taking a dose of this medicine. Antacids or iron can make it harder for your body to absorb cefdinir. This does not include baby formula fortified with iron.\nAntibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\n'),(638,'ondansetron','Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Chemotherapy Induced:\nOral:\nHighly Emetogenic Cancer Chemotherapy (HEC):\n-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater)\nModerately Emetogenic Cancer Chemotherapy (MEC):\n-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy\nParenteral:\n-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.\n-Maximum dose: 16 mg per dose\nComments:\n-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.\n-The injection formulation should be diluted prior to IV administration.\nUses:\n-Prevention of nausea and vomiting associated with HEC or MEC\n-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy\nUsual Adult Dose of Ondansetron for Nausea/Vomiting:\nOral:\nHighly Emetogenic Cancer Chemotherapy (HEC):\n-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater)\nModerately Emetogenic Cancer Chemotherapy (MEC):\n-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy\nParenteral:\n-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.\n-Maximum dose: 16 mg per dose\nComments:\n-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.\n-The injection formulation should be diluted prior to IV administration.\nUses:\n-Prevention of nausea and vomiting associated with HEC or MEC\n-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy\nUsual Adult Dose of Ondansetron for Nausea/Vomiting -- Postoperative:\nOral:\n-Recommended dose: 16 mg orally 1 hour before the induction of anesthesia\nParenteral:\n-Recommended dose: 4 mg IV (undiluted) immediately before induction of anesthesia or postoperatively (nausea and/or vomiting within 2 hours after surgery)\n-Alternative route: 4 mg IM (undiluted)\nComment:\n-Administration of a second dose does not provide additional control of nausea and vomiting.\nUse:\n-Prevention of postoperative nausea and vomiting\nUsual Adult Dose for Nausea/Vomiting--Radiation Induced:\nRecommended dose: 8 mg orally 3 times a day\n-Total Body Irradiation: 8 mg orally 1 to 2 hours before each fraction of radiotherapy administered each day\n-Single High-dose Fraction Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after the completion of radiotherapy\n-Daily Fractionated Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given\nUse:\n-Prevention of nausea and vomiting associated with radiotherapy, either as total body irradiation, single high-dose fraction, or daily fractions to the abdomen\nUsual Pediatric Dose for Nausea/Vomiting -- Postoperative:\nParenteral:\n1 month to 12 years:\nLess than 40 kg:\n-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)\n40 kg and greater:\n-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)\nUse:\n-Prevention of postoperative nausea and vomiting\nUsual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced:\nOral:\n4 to 11 years:\n-Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy\n12 years and older:\n-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy\nParenteral:\n6 months to 18 years:\n-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose\n-Maximum dose: 16 mg (per dose)\nComments:\n-The injection formulation should be diluted in 50 mL prior to IV administration.\n-This drug should be used to prevent nausea and vomiting associated with moderately to highly emetogenic chemotherapy.\nUses:\n-Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy\n-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy\n Detailed Ondansetron dosage information\n','Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ondansetron.\nTaking ondansetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called \"serotonin syndrome,\" which can be fatal. Tell your doctor if you also use:\nmedicine to treat depression;\nmedicine to treat a psychiatric disorder;\na narcotic (opioid) medication; or\nmedicine to prevent nausea and vomiting.\nThis list is not complete and many other drugs can interact with ondansetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.\n Ondansetron drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere constipation, stomach pain, or bloating;\nheadache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;\nfast or pounding heartbeats;\njaundice (yellowing of the skin or eyes);\nblurred vision or temporary vision loss (lasting from only a few minutes to several hours);\nhigh levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.\nCommon ondansetron side effects may include:\ndiarrhea or constipation;\nheadache;\ndrowsiness; or\ntired feeling.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ondansetron side effects (more detail)\n','Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.\nOndansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.\nOndansetron may be used for purposes not listed in this medication guide.\n','You should not use ondansetron if you are also using apomorphine (Apokyn).\nYou should not use ondansetron if you are allergic to it or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).\nBefore taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.\nOndansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).\nSerious side effects of ondansetron include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking this medicine and call your doctor at once if you have any of these side effects. Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nBefore taking ondansetron\nYou should not use ondansetron if:\nyou are also using apomorphine (Apokyn); or\nyou are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron).\nTo make sure ondansetron is safe for you, tell your doctor if you have:\nliver disease;\nan electrolyte imbalance (such as low levels of potassium or magnesium in your blood);\ncongestive heart failure, slow heartbeats;\na personal or family history of long QT syndrome; or\na blockage in your digestive tract (stomach or intestines).\nOndansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant.\nIt is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nOndansetron is not approved for use by anyone younger than 4 years old.\nOndansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).\nHow should I take ondansetron?\nTake ondansetron exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nOndansetron can be taken with or without food.\nThe first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor\'s dosing instructions very carefully.\nTake the ondansetron regular tablet with a full glass of water.\nTo take the orally disintegrating tablet (Zofran ODT):\nKeep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.\nUse dry hands to remove the tablet and place it in your mouth.\nDo not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.\nSwallow several times as the tablet dissolves.\nTo use ondansetron oral soluble film (strip) (Zuplenz):\nKeep the strip in the foil pouch until you are ready to use the medicine.\nUsing dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away.\nDo not swallow the strip whole. Allow it to dissolve in your mouth without chewing.\nSwallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.\nWash your hands after using Zuplenz.\nMeasure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nStore at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.\n','Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\n'),(639,'onfi','Usual Adult Dose for Lennox-Gastaut Syndrome:\nInitial daily dose:\n-Body weight 30 kg or less: 5 mg orally per day\n-Body weight 30 kg or more: 10 mg orally per day\nDay 7 total daily dose:\n-Body weight 30 kg or less: 10 mg orally per day\n-Body weight 30 kg or more: 20 mg orally per day\nDay 14 daily dose:\n-Body weight 30 kg or less: 20 mg orally per day\n-Body weight 30 kg or more: 40 mg orally per day\nUse: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS)\nUsual Geriatric Dose for Lennox-Gastaut Syndrome:\nInitial dose: 5 mg orally per day\nDay 7 total daily dose:\n-Body weight 30 kg or less: 5 mg orally per day\n-Body weight 30 kg or more: 10 mg orally per day\nDay 14 daily dose:\n-Body weight 30 kg or less: 10 mg orally per day\n-Body weight 30 kg or more: 20 mg orally per day\nMaximum dose:\n-Body weight 30 kg or less: 20 mg/day\n-Body weight 30 kg or more: 40 mg/day\nUse: Adjunctive treatment of seizures associated with LGS\nUsual Pediatric Dose for Lennox-Gastaut Syndrome:\n2 years or older:\nInitial daily dose:\n-Body weight 30 kg or less: 5 mg orally per day\n-Body weight 30 kg or more: 10 mg orally per day\nDay 7 total daily dose:\n-Body weight 30 kg or less: 10 mg orally per day\n-Body weight 30 kg or more: 20 mg orally per day\nDay 14 daily dose:\n-Body weight 30 kg or less: 20 mg orally per day\n-Body weight 30 kg or more: 40 mg orally per day\nUse: Adjunctive treatment of seizures associated with LGS\n Detailed Onfi dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of clobazam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.\nOverdose symptoms may include extreme drowsiness or weakness, confusion, slow breathing, or loss of consciousness.\n','Taking Onfi with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nTell your doctor about all your other medicines, especially:\ncold or cough medicine that contains dextromethorphan;\nantifungal medicine; or\na stomach acid reducer (such as Nexium or Prilosec).\nThis list is not complete. Other drugs may interact with clobazam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Onfi drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Onfi (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nClobazam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.\nCall your doctor at once if you have:\nsevere drowsiness, feeling like you might pass out;\nunusual changes in mood or behavior;\naggression, thoughts of hurting yourself; or\nproblems with balance or muscle movement.\nThe sedative effects of clobazam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking this medicine.\nCommon Onfi side effects may include:\nconstipation;\ndrowsiness, lack of energy;\nfever; or\ndrooling.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Onfi side effects (more detail)\n','Onfi (clobazam) benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that clobazam works by enhancing the activity of certain neurotransmitters in the brain.\nOnfi is used in combination with other medications to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems.\nOnfi in for use in patients 2 years of age or older. It is not known if this medicine is safe and effective in children less than 2 years old.\n','Do not stop using Onfi suddenly, or you could have increased seizures or unpleasant withdrawal symptoms.\nClobazam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing.\nMISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nBefore taking this medicine\nYou should not take Onfi if you are allergic to clobazam.\nTo make sure Onfi is safe for you, tell your doctor if you have ever had:\nbreathing problems or lung disease;\ndepression, mood problems, or suicidal thoughts or behavior;\na drug or alcohol addiction; or\nliver or kidney disease.\nSome people have thoughts about suicide while taking clobazam. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nIf you use Onfi while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.\nDo not start or stop taking seizure medication during pregnancy without your doctor\'s advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of clobazam on the baby.\nOnfi can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using clobazam, use a back-up barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Keep using birth control for at least 28 days after your last dose of clobazam.\nIf you are breastfeeding, tell your doctor if you notice drowsiness or feeding problems in the nursing baby.\nOnfi should not be given to a child younger than 2 years old.\nHow should I take Onfi?\nTake Onfi exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Never use clobazam in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.\nNever share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nYou may take Onfi with or without food.\nIf you cannot swallow a tablet whole, you may break it in half or crush it and mix the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nTo use the oral film, place it on the top of your tongue. Swallow several times as the film dissolves, without drinking liquid.\nClobazam doses are based on weight in children. Your child\'s dose needs may change if the child gains or loses weight.\nDo not stop using Onfi suddenly, even if you feel fine. Stopping suddenly may cause increased seizures or unpleasant withdrawal symptoms. Follow your doctor\'s instructions about tapering your dose.\nTell your doctor if your seizures get worse or you have them more often while taking Onfi.\nStore at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(640,'ongentys','Usual Adult Dose for Parkinson\'s Disease:\n50 mg orally once a day at bedtime\nUse: As adjunctive treatment to levodopa/carbidopa in patients with Parkinson\'s disease (PD) experiencing \"off\" episodes\n Detailed Ongentys dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose the following night. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using Ongentys with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nTell your doctor about all your other medicines, especially:\ndobutamine;\ndopamine;\nepinephrine, norepinephrine; or\nisoproterenol.\nThis list is not complete. Other drugs may interact with opicapone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Ongentys drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Ongentys: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nconfusion, hallucinations (hearing or seeing something that is not there);\naggression, agitation, unusual thoughts or behavior;\nuncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); or\nworsening tremors, stiffness, or muscle spasms.\nYou may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.\nCommon Ongentys side effects may include:\nfeeling light-headed;\nuncontrolled muscle movement;\nabnormal blood tests;\nconstipation; or\nweight loss.\nWhen you stop taking Ongentys, watch for withdrawal symptoms such as: stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, or feeling like you might pass out.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ongentys side effects (more detail)\n','Ongentys (opicapone) is a prescription medicine that inhibits the enzyme catechol-O-methyltransferase (COMT). COMT is involved in the degradation of certian neurotransmitters such as dopamine, epinephrine, and norepinephrine.\nOngentys is used together with carbidopa and levodopa to treat symptoms of \"off\" episodes (stiffness, tremors, muscle spasms, poor muscle control) in people with Parkinson\'s disease.\nIt is not known if Ongentys is safe and effective in children.\n','Do not use Ongentys if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine and others.\nDo not use Ongentys if you have a tumor that secretes hormones known as catecholamines. These tumors include pheochromocytoma (a type of adrenal gland tumor) and paraganglioma.\nBefore taking this medicine\nYou should not use Ongentys if you are allergic to opicapone, or if you have a certain type of tumor that secretes hormones, such as:\npheochromocytoma (tumor of the adrenal gland); or\nparaganglioma (tumor of the nerve cells).\nTo make sure Ongentys is safe for you, tell your doctor if you have ever had:\na sleep disorder that causes daytime sleepiness;\nnarcolepsy or other conditions that cause sudden sleepiness;\nuncontrolled muscle movements;\nunusual and intense urges to act on impulse (such as gambling, binge-eating, or compulsive shopping);\nmental illness, hallucinations, or psychosis;\nliver disease; or\nkidney disease.\nTell your doctor if you are pregnant or breastfeeding.\nHow should I take Ongentys?\nTake Ongentys exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nWhen you start or stop taking Ongentys, your doctor may need to adjust the doses of any other medicines you take for Parkinson\'s disease.\nOngentys is usually taken at bedtime. Follow your doctor\'s dosing instructions very carefully.\nTake Ongentys on an empty stomach. Do not eat for at least 1 hour before or 1 hour after taking this medicine.\nYour blood pressure may need to be checked often.\nOngentys may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.\nDo not change your doses or stop using any of your medicines without your doctor\'s advice. Tell your doctor if any of your medicines seem to stop working.\nStore at room temperature away from moisture and heat.\n','Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(641,'onglyza','Usual Adult Dose for Diabetes Type 2:\n2.5 or 5 mg orally once a day, regardless of meals\nCoadministration with strong CYP450 3A4/5 inhibitors: 2.5 mg orally once a day\nUse: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in multiple clinical settings\n Detailed Onglyza dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and take your next dose at the regular time, unless your doctor tells you otherwise. Do not take two doses at one time, and do not take an extra dose the next day.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).\n','Other drugs may increase or decrease the effects of saxagliptin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Onglyza drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Onglyza: hives, a purple or red skin rash that spreads and causes blistering and peeling; difficulty breathing; swelling of your face, lips, tongue, or throat.\nStop taking Onglyza and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.\nCall your doctor at once if you have:\nsevere or ongoing pain in your joints;\npain or burning when you urinate; or\nheart problems - shortness of breath (even while lying down), feeling weak or tired, rapid weight gain, swelling (especially in your feet, legs, or midsection.\nCommon Onglyza side effects may include:\npainful urination;\nheadache;\nrunny or stuffy nose, sore throat, cough; or\nswelling in your hands or feet.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Onglyza side effects (more detail)\n','Onglyza (saxagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.\nOnglyza is used together with diet and exercise to improve blood sugar control in adults with type 2 type 2 diabetes mellitus.\nOnglyza is not for treating type 1 diabetes.\nOnglyza is sometimes used in combination with other diabetes medications.\n','You should not use Onglyza if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).\nOnglyza is not for treating type 1 diabetes.\nBefore you take this medicine, tell your doctor if you have kidney disease or if you are on dialysis.\nOnglyza is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.\nBefore taking this medicine\nYou should not use Onglyza if you have ever had a severe allergic reaction to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment).\nTo make sure Onglyza is safe for you, tell your doctor if you have ever had:\nkidney disease (or if you are on dialysis);\nheart disease;\npancreatitis;\ngallstones;\nhigh triglycerides (a type of fat in the blood); or\nalcoholism.\nFollow your doctor\'s instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nOnglyza is not approved for use by anyone younger than 18 years old.\nHow should I take Onglyza?\nTake Onglyza exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nYou may take Onglyza with or without food. Follow your doctor\'s instructions.\nSwallow the tablet whole and do not crush, chew, or break it.\nYour blood sugar will need to be checked often, and you may need other blood tests at your doctor\'s office.\nYou may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).\nYour doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.\nBlood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.\nOnglyza is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor\'s instructions very closely.\nStore at room temperature away from moisture and heat\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(642,'onpattro','Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:\nDosing is based on actual body weight; premedication should be given at least 60 minutes prior to the start of the infusion\nWeight less than 100 kg: 0.3 mg/kg via IV infusion every 3 weeks\nWeight 100 kg or greater: 30 mg via IV infusion every 3 weeks\nInitial infusion rate should be approximately 1 mL/min for the first 15 minutes, then increase to approximately 3 mL/min for the remainder of the infusion; in the event of an infusion related reaction, the duration of infusion may be extended; see administration advice for infusion instructions\nPREMEDICATION: Administer on day of infusion at least 60 minutes prior to start of infusion:\n-Acetaminophen 500 mg orally\n-IV corticosteroid (e.g., dexamethasone 10 mg or equivalent)\n-IV H1 blocker (e.g. diphenhydramine 50 mg or equivalent)\n-IV H2 blocker (e.g., ranitidine 50 mg or equivalent)\nComments:\n-Premedications are required to reduce the risk of infusion related reactions (IRR).\n-If IV premedications are not available or not tolerated, oral equivalents may be used\n-If patients are tolerating the infusion, but experiencing adverse reactions to corticosteroid premedication, reduce corticosteroid in 2.5 mg increments to a minimum IV dose of dexamethasone 5 mg or equivalent\n-Some patients may require additional or higher doses of one or more premedications to reduce the risk of IRRs.\nUse: For the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis.\n Detailed Onpattro dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss an appointment for your Onpattro.\nWhat happens if I overdose?\nSince Onpattro is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.\n','Other drugs interact with Onpattro, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n','Get emergency medical help if you have signs of an allergic reaction to Onpattro: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSome side effects may occur during the injection. Tell your caregiver if you feel warm, dizzy, nauseated, light-headed, or have a headache, fast heartbeats, swelling in your face, stomach pain, chest pain, or trouble breathing.\nCommon Onpattro side effects may include:\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Onpattro side effects (more detail)\n','Onpattro (patisiran) a double-stranded small interfering ribonucleic acid (siRNA), formulated as a lipid complex injection.\nOnpattro is a prescription medicine used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hereditary transthyretin-mediated amyloidosis (hATTR).\nOnpattro is given by intravenous (IV) infusion.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nBefore using Onpattro tell your doctor about all your medical conditions or allergies.\nIt is not known whether Onpattro will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of patisiran on the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nHow is Onpattro given?\nOnpattro is given as an infusion into a vein. A healthcare provider will give you this injection once every 3 weeks.\nThis medicine must be given slowly, and the infusion can take about 80 minutes to complete.\nTell your caregivers if you feel any burning, pain, or swelling around the IV needle when Onpattro is injected.\nYou may be given other medications to help prevent serious side effects or an infusion reaction.\nYour doctor may have you take extra vitamin A while you are using Onpattro. Take only the amount of vitamin A your doctor has prescribed, especially if you are pregnant. An overdose of vitamin A can cause vision problems or other serious side effects.\nCall your doctor at once if you have vision problems (especially at night) while you are taking vitamin A.\nOnpattro doses are based on weight. Your dose needs may change if you gain or lose weight.\nYou may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. You may also need frequent eye exams.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(643,'onureg','Use Onureg exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nOnureg tablets are taken by mouth in a 28-day treatment cycle. You may need to take the medicine only during the first 2 weeks of each cycle.\nTake Onureg at the same time each day, with or without food. Swallow the tablet whole and do not crush, chew, or break it.\nDo not use a broken tablet. The medicine from a broken pill can be dangerous if it gets in your mouth, eyes, or nose, or on your skin. If this happens, wash your skin with soap and water or rinse your eyes with water.\nIf you vomit shortly after taking Onureg, do not take another dose. Wait until your next scheduled dose time to take the medicine again.\nYour treatment schedule may be different. Your doctor will determine how long to treat you with azacitidine. Onureg tablets should not be used in place of Vidaza (azacitidine) injection. The oral and injection forms of this medicine have different uses and dosages.\nYou may also be given medicine to reduce nausea and vomiting. Use this medicine only as prescribed.\nAzacitidine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your kidney function may also need to be tested.\nStore Onureg at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. Keep the container tightly closed when not in use.\n Detailed Onureg dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with azacitidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Onureg drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Onureg: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere ongoing nausea, vomiting, or diarrhea;\nredness, swelling, warmth, oozing, or other signs of skin infection;\nlow blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;\nsigns of a lung infection--fever, cough with mucus, chest pain, feeling short of breath;\nkidney problems--pain in your lower back, blood in your urine, little or no urination, swelling in your feet or ankles;\nliver problems--upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nlow potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or\nsigns of tumor cell breakdown--tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth.\nCommon Onureg side effects may include:\nfever, chills, bruising, or other signs of low blood cell counts;\nlung infection;\nlow potassium;\nnausea, vomiting, stomach pain, loss of appetite;\nconstipation, diarrhea;\njoint pain, pain in your arms or legs;\nfeeling weak or tired; or\ndizziness.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Onureg side effects (more detail)\n','Onureg (azacitidine) is a prescription medicine used for continued treatment of adults with acute myeloid leukemia (AML) who:\nhad a first complete remission (CR) following intensive induction chemotherapy with or without recovery of your blood cell counts, and\nwho are not able to complete intensive curative therapy.\nIt is not known if Onureg is safe and effective in children under 18 years of age.\n','Both men and women using Onureg should use effective birth control to prevent pregnancy. Azacitidine can harm an unborn baby if the mother or father is using this medicine.\nBefore taking this medicine\nYou should not use Onureg if you are allergic to azacitidine.\nTo make sure Onureg is safe for you, tell your doctor if you have:\nkidney disease; or\nliver disease.\nAzacitidine can harm an unborn baby if the mother or the father is using this medicine.\nIf you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use Onureg if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine. If you take Onureg, keep using birth control for at least 6 months after your last dose.\nIf you are a man, use effective birth control if your sex partner is able to get pregnant. If you take Onureg, keep using birth control for at least 3 months after your last dose.\nTell your doctor right away if a pregnancy occurs while either the mother or the father is using Onureg.\nOnureg may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because this medicine can harm an unborn baby.\nYou should not breastfeed while using Onureg. Also do not breastfeed for at least 1 week after your last dose of Onureg.\n','Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.\n'),(644,'opana','Usual Adult Dose of Opana for Pain:\nThe following dosing recommendations can only be considered suggested approaches to what is actually a series of clinical decisions over time; each patient should be managed individually.\nORAL:\nUse as first Opioid Analgesic:\n-Initial dose: 10 to 20 mg orally every 4 to 6 hours as needed for pain\nMaximum initial dose: 20 mg\nConversion from Other Oral Opioids to Oral Oxymorphone:\n-Determine equipotent dose using published potency tables; it is safest to start therapy by administering one-half the calculated total daily oxymorphone requirement in 4 to 6 equally divided oral doses every 4 to 6 hours and gradually adjust dose as needed.\nComments:\n-Dose conversion should be done carefully and with close monitoring due to large patient variability in regards to opioid analgesic response.\n-Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.\n-Monitor closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and with each dose increase.\n-Due to risks of addiction, abuse, and misuse, even at recommended doses, reserve use for patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products) have not been tolerated, or are not expected to be tolerated, or have not provided adequate analgesia, or are not expected to provide adequate analgesia.\nUsual Adult Dose of Opana ER for Chronic Pain:\nUse as the First Opioid Analgesic or for those who are NOT Opioid Tolerant:\nInitial dose: Extended-release tablets: 5 mg orally every 12 hours\nCONVERSION DOSES:\nImmediate-Release Oxymorphone to Extended-Release Oxymorphone Tablets: Administer same total daily dose\n-Initial dose: One-half total daily immediate-release requirement as extended-release tablet orally every 12 hours\nFrom Other Oral Opioids to Oxymorphone Extended-Release Tablets:\n-Discontinue all other around-the-clock opioid drugs when oxymorphone extended-release therapy is initiated.\n-Published potency tables can be used to estimate a patient\'s 24-hour oral oxymorphone requirement; however, due to substantial inter-patient variability, the conversion should then underestimate a patient\'s 24-hour requirement and provide rescue medication as the dose is titrated.\n-Alternatively, the following conversion factors (CF) may be used to convert selected oral opioids to the extended-release oxymorphone tablet: Oxymorphone, CF=1; Hydrocodone, CF=0.5; Oxycodone, CF=0.5; Methadone, CF= 0.5, Morphine, CF=0.333\n-As an example: Sum the total daily dose of prior oral opioid; multiply that sum by the CF to obtain 24-hour oral oxymorphone requirement; divide by 2 to calculate approximate starting dose to be given every 12 hours, round down, if necessary.\n-These CFs cannot be used to convert from oxymorphone extended-release tablets to the selected oral opioid as doing so will result in overestimation of the oral opioid dose and may result in fatal respiratory depression\nTITRATION AND MAINTENANCE:\nMaintenance Dose: Individually titrate to a dose that provides adequate analgesia and minimizes adverse reactions; dose adjustments may be made in 5 to 10 mg increments every 12 hours, every 3 to 7 days.\nBreakthrough Pain: If the level of pain increases after dose stabilization, attempt to identify the source before increasing dose; rescue medication with appropriate immediate-release analgesia may be helpful\nComments:\n-An opioid tolerant patient is one who has been receiving for 1-week or longer at least: oral morphine 60 mg/day, fentanyl transdermal patch 25 mcg per hour, oral oxycodone 30 mg/day, oral hydromorphone 8 mg/day, oral oxymorphone 25 mg/day, or an equianalgesic dose of another opioid\n-When converting from methadone, close monitoring is of particular importance due to methadone\'s long half-life.\n-Dose conversion should be done carefully and with close monitoring due to large patient variability in regards to opioid analgesic response.\n-Upon cessation of therapy in the physically dependent patient, individually taper reassessing frequently to manage pain and withdrawal symptoms.\n Detailed Opana dosage information\nWhat happens if I miss a dose?\nSince Opana is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An oxymorphone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.\nYour doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don\'t wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.\nAnyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.\n','Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother opioids - opioid pain medicine or prescription cough medicine;\na sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and others;\ndrugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or\ndrugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete. Other drugs may interact with oxymorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Opana drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Opana: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nweak or shallow breathing, breathing that stops;\na light-headed feeling, like you might pass out;\nseizure (convulsions);\nchest pain, wheezing, cough with yellow or green mucus;\nsevere vomiting;\nhigh levels of serotonin in the body - agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; or\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.\nSerious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.\nCommon Opana side effects may include:\ndizziness, drowsiness;\nheadache, tiredness; or\nstomach pain, nausea, vomiting, constipation.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Opana side effects (more detail)\n','Opana (oxymorphone) is an opioid pain medication. An opioid is sometimes called a narcotic.\nOpana is used to treat moderate to severe pain.\nOpana ER, the extended-release form of oxymorphone, is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain.\n','You should not use Opana if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or moderate to severe liver disease.\nOxymorphone can slow or stop your breathing, and may be habit-forming. MISUSE OF OPANA CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.\nTaking Opana during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use Opana with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore taking this medicine\nYou should not take Opana if you are allergic to oxymorphone, or if you have:\nsevere asthma or breathing problems;\nsevere liver disease; or\na stomach or bowel obstruction (including paralytic ileus).\nTo make sure Opana is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea (breathing that stops during sleep);\na head injury or seizures;\ndrug or alcohol addiction, or mental illness;\nurination problems;\nliver or kidney problems; or\nproblems with your gallbladder, pancreas, or thyroid.\nIf you use Opana while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.\nAsk a doctor before using Opana if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.\nHow should I use Opana?\nTake Opana exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use Opana in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.\nNever share Opana with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.\nStop using all other around-the-clock opioid pain medications when you start taking Opana.\nTake Opana on an empty stomach, at least 1 hour before or 2 hours after a meal.\nTake the medicine at the same times each day.\nSwallow the tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, or dissolve.\nTake only one Opana ER extended-release tablet at a time. To avoid choking, do not lick or wet the tablet before placing it in your mouth.\nNever crush or break an Opana pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.\nDo not stop using Opana suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Opana.\nStore at room temperature away from moisture, heat, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.\nDo not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(645,'opdivo','Opdivo is given as an infusion into a vein by a healthcare provider. This medicine must be given slowly, and the infusion can take 30 to 90 minutes to complete.\nOpdivo is usually given once every 2 to 4 weeks. Your other cancer medicines may be given on different schedules. Your doctor will determine how long to treat you with all medicines.\nYou will need frequent medical tests to help your doctor determine if it is safe for you to keep receiving Opdivo.\nOpdivo can cause side effects in many different parts of your body. You may be given medication to prevent certain side effects, and your cancer treatments may be delayed if you need treatment for a side effect.\n Detailed Opdivo dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss a chemotherapy appointment.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with nivolumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Opdivo drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Opdivo (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nSome side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, short of breath, itchy, or tingly, or if you have a fever, chills, back pain or neck pain.\nCall your doctor at once if you have:\nsevere or ongoing diarrhea, severe stomach pain, bloody or tarry stools;\neye pain, vision changes, sensitivity to light;\nsevere muscle pain or weakness;\nconfusion, memory problems, neck stiffness, drowsiness, balance problems;\nnumbness or tingling in your arms or legs;\nkidney problems - little or no urination, swelling in your feet or ankles, blood in your urine;\nliver problems - severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);\nlung problems - new or worsening cough, chest pain, feeling short of breath;\nskin problems - rash, itching, redness, swelling, pain, sores, blisters, sores in your mouth or nose or on your genitals;\nsigns of a hormonal disorder - frequent or unusual headaches, vision problems, fast heartbeats, dizziness, fainting, tiredness, mood or behavior changes, hunger, increased thirst or urination, constipation, hair loss, hoarse or deepened voice, sweating, feeling cold, weight gain or loss; or\n(if you have had a stem cell transplant) feeling sick or uneasy, with pain or swelling near your transplanted organ.\nYour cancer treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon Opdivo side effects may include:\nnausea, vomiting, stomach pain, loss of appetite, diarrhea, constipation;\nmouth sores, altered sense of taste;\nitching, rash, redness or blisters on your hands or feet;\nhormonal problems;\nliver problems;\nnumbness, tingling, or burning pain in your hands or feet;\nfever, body aches;\nfeeling weak, tired, or short of breath;\ncold symptoms such as runny or stuffy nose, cough, sore throat;\nheadache, dizziness, increased blood pressure; or\nweight loss.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Opdivo side effects (more detail)\n','Opdivo (nivolumab) is a cancer medicine that is used alone or in combination with other medicines that works with your immune system to interfere with the growth and spread of cancer cells in the body.\nOpdivo is used alone or in combination with other medicines to treat adults with:\nadvanced skin cancer (melanoma);\nadvanced non-small cell lung cancer;\npleural mesothelioma (cancer that affects the lining of the lungs and chest wall);\nkidney cancer;\nclassical Hodgkin lymphoma;\ncancer of the stomach and esophagus;\nsquamous cell cancer of the esophagus or head and neck;\nbladder cancer;\nliver cancer; or\ncolorectal cancer.\nOpdivo is often given when the cancer has spread to other parts of the body (metastatic), or cannot be surgically removed, or has come back after prior treatment. Opdivo is sometimes given only if laboratory testing shows specific genetic markers or DNA mutations associated with your cancer.\n','Opdivo can cause side effects in many different parts of your body. Some side effects may need to be treated with other medicine, and your cancer treatments may be delayed.\nCall your doctor at once if you have: a cough, shortness of breath, vision changes, muscle pain or weakness, stomach pain, diarrhea, blood in your stools, little or no urinating, bruising or bleeding, dark urine, yellowing of your skin or eyes, frequent headaches, dizziness, confusion, increased thirst or urination, skin problems, numbness or tingling, feeling cold, or weight gain or loss.\nBefore taking this medicine\nTo make sure Opdivo is safe for you, tell your doctor if you have:\nchemotherapy or radiation treatment;\na nervous system disorder such as myasthenia gravis or Guillain-Barré syndrome;\nliver disease;\nan autoimmune disorder (lupus, Crohn\'s disease, ulcerative colitis); or\nan organ transplant, or a stem cell transplant from a donor.\nNivolumab may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while receiving Opdivo and for at least 5 months after your last dose. Tell your doctor if you become pregnant.\nDo not breastfeed while using this medicine, and for at least 5 months after your last dose.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(646,'orencia','Usual Adult Dose of Orencia for Rheumatoid Arthritis:\nIV:\n-Less than 60 kg, give 500 mg\n-If 60 to 100 kg, give 750 mg\n-If greater than 100 kg, give 1000 mg\nAdminister once as a 30-minute IV infusion. The dose is repeated 2 and 4 weeks after the initial dose, then every 4 weeks thereafter. It may be administered alone or with disease-modifying antirheumatic drugs other than TNF antagonists.\nSUBCUTANEOUS:\n-After a single IV infusion as a loading dose (as per body weight categories above), 125 mg administered by subcutaneous injection should be given within a day, followed by 125 mg subcutaneously once a week.\n-Patients who are unable to receive an infusion may initiate weekly injections subcutaneously without an IV loading dose.\n-Patients transitioning from IV therapy to subcutaneous administration should administer the first subcutaneous dose instead of the next scheduled IV dose.\nComments:\n-This drug should not be administered concomitantly with TNF antagonists or used concomitantly with other biologic rheumatoid arthritis (RA) therapy, such as anakinra.\nUse: For reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis. This drug may be used as monotherapy or concomitantly with disease-modifying antirheumatic drugs (DMARDs) other than tumor necrosis factor (TNF) antagonists.\nUsual Pediatric Dose of Orencia for Juvenile Idiopathic Arthritis:\nIV:\n6 to 17 years:\nIf less than 75 kg, give 10 mg/kg IV\n75 kg to 100 kg, give 750 mg IV\nIf greater than 100 kg, give 1000 mg IV\n-The maximum dose per intravenous administration should not exceed 1000 mg.\n-Administer once as a 30-minute IV infusion. The dose is repeated 2 and 4 weeks after the initial dose, then every 4 weeks thereafter. It may be administered alone or concomitantly with methotrexate.\nSUBCUTANEOUS:\n2 years and older:\nThe subcutaneous injection should be given without an IV loading dose:\n10 kg to less than 25 kg: 50 mg subcutaneously once a week\n25 kg to less than 50 kg: 87.5 mg subcutaneously once a week\n50 kg or more: 125 mg subcutaneously once a week\nComments:\n-This drug should not be administered concomitantly with TNF antagonists or used concomitantly with other biologic rheumatoid arthritis (RA) therapy, such as anakinra.\n-The safety and efficacy of the auto-injector for subcutaneous injection has not been studied in patients under 18 years of age.\nUse: For reducing signs and symptoms in pediatric patients 2 years of age and older with moderately to severely active polyarticular juvenile idiopathic arthritis. This drug may be used as monotherapy or concomitantly with methotrexate (MTX).\n Detailed Orencia dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss your Orencia dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your other medicines, especially:\nadalimumab;\nanakinra;\ncertolizumab;\netanercept;\ngolimumab;\ninfliximab;\nrituximab; or\ntocilizumab.\nThis list is not complete. Other drugs may interact with abatacept, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Orencia drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Orencia: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nSome side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, light-headed, itchy, or have a severe headache or trouble breathing within 1 hour after receiving the injection.\nYou may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:\nfever, chills, night sweats, flu symptoms, weight loss;\nfeeling very tired;\ndry cough, sore throat; or\nwarmth, pain, or redness of your skin.\nCall your doctor at once if you have any of these other serious side effects:\ntrouble breathing;\nstabbing chest pain, wheezing, cough with yellow or green mucus;\npain or burning when you urinate; or\nsigns of skin infection such as itching, swelling, warmth, redness, or oozing.\nCommon Orencia side effects may include:\nfever;\nnausea, diarrhea, stomach pain;\nheadache; or\ncold symptoms such as stuffy nose, sneezing, sore throat, cough.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Orencia side effects (more detail)\n','Orencia (abatacept) is a protein that prevents your body\'s immune system from attacking healthy tissues such as joints. The immune system helps your body fight infections. In people with autoimmune disorders, the immune system mistakes the body\'s own cells for invaders and attacks them.\nOrencia is a prescription medicine used to treat symptoms of rheumatoid arthritis, and to prevent joint damage caused by these conditions. This medicine is for adults and children at least 2 years old.\nOrencia is also used to treat active psoriatic arthritis in adults.\nOrencia is not a cure for any autoimmune disorder and will only treat the symptoms of your condition.\n','Before using Orencia, tell your doctor if you have ever had tuberculosis (TB), if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.\nAlso tell your doctor if you have a weak immune system, any type of infection (including skin infection or open sores), COPD, diabetes, a history of hepatitis, or if you have scheduled to receive any vaccinations.\nChildren using this medication should be current on all childhood immunizations before starting treatment with Orencia. Serious infections may occur during treatment with Orencia. Contact your doctor right away if you have signs of infection such as: fever, chills, dry cough, sore throat, night sweats, tired feeling, weight loss, or painful warmth or redness of your skin.\nBefore taking this medicine\nYou should not use Orencia if you are allergic to abatacept.\nBefore using Orencia, tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.\nTo make sure Orencia is safe for you, tell your doctor if you have ever had:\na weak immune system;\nany type of infection including a skin infection or open sores;\ninfections that go away and come back;\nCOPD (chronic obstructive pulmonary disease);\ndiabetes;\nhepatitis; or\nif you are scheduled to receive any vaccines.\nUsing Orencia may increase your risk of developing certain types of cancer such as lymphoma (cancer of the lymph nodes). This risk may be greater in older adults. Talk to your doctor about your specific risk.\nTell your doctor if you are pregnant or breastfeeding.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of abatacept on the baby.\nChildren using Orencia should be current on all childhood immunizations before starting treatment.\nHow should I use Orencia?\nOrencia is injected under the skin, or as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.\nBefore you start treatment with Orencia, your doctor may perform tests to make sure you do not have tuberculosis or other infections.\nOrencia is injected under the skin when given to a child between 2 and 6 years old.\nOrencia must be given slowly when injected into a vein, and the IV infusion can take at least 30 minutes to complete.\nThis medicine is usually given every 1 to 4 weeks. Follow your doctor\'s instructions.\nOrencia must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don\'t understand all instructions.\nPrepare an injection only when you are ready to give it. Gently swirl but do not shake the medication bottle. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.\nEach vial (bottle) or prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.\nUse a needle and syringe only once and then place them in a puncture-proof \"sharps\" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.\nIf you need surgery, tell the surgeon ahead of time that you are using Orencia.\nIf you\'ve ever had hepatitis B, using Orencia can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.\nOrencia can cause false results with certain blood glucose tests, showing high blood sugar readings. If you have diabetes, talk to your doctor about the best way to test your blood sugar.\nAutoimmune disorders are often treated with a combination of different drugs. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor\'s advice.\nStore Orencia in original carton in a refrigerator. Protect from light and do not freeze. Do not use after the expiration date on the medicine label has passed.\nIf you need to travel with your medicine, place the syringes in a cooler with ice packs.\nOrencia mixed with a diluent may be stored in a refrigerator or at room temperature and must be used within 24 hours.\n','Do not receive a \"live\" vaccine while using Orencia, and for at least 3 months after your treatment ends. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.\nAvoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.\n'),(647,'orgovyx','Usual Adult Dose of Orgovyx for Prostate Cancer:\nLoading Dose: 300 mg orally once on the first day\nMaintenance Dose: 120 mg orally once a day\nComment:\n-Treatment is usually continued upon development of nonmetastatic or metastatic castration-resistant prostate cancer in patients treated with GnRH receptor agonists and antagonists.\nUse: For the treatment of adult patients with advanced prostate cancer\n Detailed Orgovyx dosage information\nWhat happens if I miss a dose?\nTake Orgovyx as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time.\nIf you miss more than 7 daily doses, your doctor may want you to restart the medicine by taking 3 tablets the first day and 1 daily tablet thereafter.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nCertain other drugs should not be used within 6 hours after you take this medicine. Your Orgovyx dose should be taken first, before the other medicine. Carefully follow your doctor\'s instructions about how to schedule the doses of all your medicines.\nOther drugs may interact with relugolix, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Orgovyx drug interactions (more detail)\nInactive ingredients\nMannitol, sodium starch glycolate, hydroxypropyl cellulose, magnesium stearate, hypromellose, titanium dioxide, ferric oxide red, and carnauba wax. mannitol, sodium starch glycolate, hydroxypropyl cellulose, magnesium stearate, hypromellose, titanium dioxide, ferric oxide red, and carnauba wax.\n','Get emergency medical help if you have signs of an allergic reaction to Orgovyx: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nfast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);\nchest pain or pressure;\nsudden numbness or weakness on one side of the body;\nlittle or no urination, pain or burning when you urinate;\nbreast pain or swelling;\ndepressed mood; or\nunusual bleeding.\nCommon Orgovyx side effects may include:\nflushing (sudden warmth, redness, or tingly feeling);\nfeeling tired;\nweight gain;\nimpotence, sexual problems;\ndiarrhea, constipation;\nmuscle or joint pain; or\nabnormal lab tests.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n','Orgovyx (relugolix) is a GnRH receptor antagonist that blocks the pituitary gland from making certain hormones.\nOrgovyx is a prescription medicine used to treat advanced prostate cancer.\nIt is not known if Orgovyx is safe or effective in females or in children.\nOrgovyx 120 mg tablets are film-coated, light red, almond shaped, with the imprint \"R\" on one side and \"120\" on the other side. The tablets are available in bottles or blister packs.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nOrgovyx is not for use in women or children.\nTo make sure Orgovyx is safe for you, tell your doctor if you have ever had:\nheart problems; or\nlong QT syndrome (in you or a family member).\nUse effective birth control if your sex partner is pregnant or able to get pregnant. Relugolix can harm an unborn baby if the father is using Orgovyx. Keep using birth control for at least 2 weeks after your last dose of this medicine.\nRelugolix may affect fertility (your ability to have children). However, it is important to use birth control if your partner is pregnant or able to get pregnant because relugolix can harm an unborn baby.\nHow should I take Orgovyx?\nUse Orgovyx exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nOrgovyx is usually taken as 3 tablets the first day, followed by 1 tablet per day from then on.\nTake Orgovyx at the same time each day, with or without food.\nSwallow the tablet whole and do not crush, chew, or break it.\nYou may need frequent blood tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).\nYour doctor will determine how long to treat you with Orgovyx. Do not change your dose or stop using this medicine without your doctor\'s advice.\nStore at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.\nKeep the bottle tightly closed when not in use.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(648,'oriahnn','Usual Adult Dose for Uterine Fibroids:\nOne capsule orally twice a day\n-Morning capsule contains elagolix 300 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg\n-Evening capsule contains elagolix 300 mg\nDuration of therapy: 24 months\nComments:\n-Rule out pregnancy prior to starting therapy or start therapy within 7 days from the onset of menses.\n-Take capsules twice a day at approximately the same time each day.\n-Duration of use should be limited to 24-months due to risk of bone loss.\nUse: For the management of heavy menstrual bleeding associated with uterine leiomyomas (fibroids) in premenopausal women.\n Detailed Oriahnn dosage information\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose may cause nausea, vomiting, stomach pain, breast tenderness, severe drowsiness or tiredness, or vaginal bleeding.\n','Tell your doctor about all your other medicines, especially:\nthyroid medicine; or\ncortisol replacement therapy;\nOther drugs may interact with elagolix, estradiol, and norethindrone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Oriahnn drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Oriahnn: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nThis medicine may increase your risk of heart attack, stroke, or blood clot. Stop using this medicine and seek medical attention right away if you have:\nchest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;\nswelling, pain, warmth, or redness in an arm or leg;\nsudden shortness of breath;\nsudden numbness, weakness, or severe headache;\nvision problems, bulging eyes; or\ntrouble speaking.\nCall your doctor at once if you have:\nhigh blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;\nany new or worsening mood symptoms - mood or behavior changes, depression, anxiety, thoughts about suicide or hurting yourself; or\nliver or gallbladder problems - loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, bruising, swelling, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nOriahnn may cause hair loss that may be permanent.\nCommon Oriahnn side effects may include:\nhot flashes;\nfeeling tired;\nhair loss (may be permanent);\nheadache; or\nirregular menstrual periods.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oriahnn side effects (more detail)\n','Oriahnn contains a combination of elagolix, estradiol, and norethindrone.\nOriahnn is a prescription medicine used to control heavy menstrual bleeding in adult women with uterine fibroids.\nOriahnn is not for use in women who have entered menopause.\n','Do not use Oriahnn if you are pregnant.\nYou should not use Oriahnn if you have: uncontrolled high blood pressure, heart disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease, severe migraine headaches, osteoporosis, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.\nTaking Oriahnn can increase your risk of blood clots, stroke, or heart attack. Your risk of these side effects is highest if you are older than 35 and you smoke, or if you have high cholesterol, diabetes, uncontrolled high blood pressure, or if you are overweight.\nStop taking Oriahnn and seek medical attention right away if you have chest pain spreading to your jaw or shoulder, a sudden severe headache, problems with vision or speech, or swelling or pain in your leg.\nBefore taking this medicine\nYou should not use Oriahnn if you are allergic to elagolix, estradiol, or norethindrone, or if you have:\na history of heart attack, stroke;\na blood clot in your heart, lungs, legs, or eyes;\nblood circulation problems;\na heart valve disorder or heart rhythm problems;\nuncontrolled high blood pressure;\nproblems caused by diabetes that affect your eyes, kidneys, nerves, or blood vessels;\nsevere migraine headaches (with aura), especially if you are older than 35;\ngallbladder problems;\na history of hormone-related cancer (such as cancer of the breast, uterus/cervix, or vagina);\nosteoporosis; or\nabnormal vaginal bleeding that has not been checked by a doctor.\nTaking Oriahnn can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight.\nSmoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take Oriahnn if you smoke and are over 35 years old.\nOriahnn may also cause bone loss, which may be partially permanent. It is not known if this could increase your risk of bone fracture.\nOriahnn is not a birth control medication and will not prevent pregnancy. You may need to have a negative pregnancy test before starting this treatment.\nDo not take Oriahnn if you are pregnant or trying to get pregnant. Oriahnn may increase your risk of miscarriage. Use effective birth control to prevent pregnancy while taking this medicine and for at least 1 week after your last dose.\nTo prevent pregnancy while using Oriahnn, use a non-hormonal form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Avoid using birth control pills, injections, implants, skin patches, and vaginal rings.\nStop taking Oriahnn and call your doctor right away if you think you might be pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of elagolix, estradiol, and norethindrone on the baby.\nOriahnn may change your menstrual periods (decreased or no bleeding), which could make it harder to know if you are pregnant. Watch for other signs of pregnancy such as breast tenderness, weight gain, and nausea.\nTo make sure Oriahnn is safe for you, tell your doctor if you have ever had::\nbone problems, including broken bones;\ndepression, a mood disorder, or suicidal thoughts; or\njaundice (yellowing of your skin or eyes) caused by pregnancy or birth control.\nHow should I take Oriahnn?\nTake Oriahnn exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You should not take this medicine for longer than 24 months.\nOriahnn comes in different capsule colors. The white/yellow capsule is usually taken in the morning, and the white/blue capsule is taken in the evening. Follow your doctor\'s dosing instructions very carefully.\nTake the medicine at the same times each day, with or without food.\nYour doctor may have you take extra vitamin D and calcium while you are taking Oriahnn. Take these supplements only as your doctor has prescribed. Avoid taking iron supplements if you also take vitamin D and calcium supplements.\nIf you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.\nYour blood pressure will need to be checked often. You may also need scans to check your bone mineral density before and during treatment with Oriahnn.\nOriahnn can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.\nStore at room temperature away from moisture and heat.\nDo not keep leftover capsules. Ask your pharmacist where to locate a drug take-back disposal program. Do not flush the unused medicine down a toilet.\n','Do not smoke while taking Oriahnn, especially if you are older than 35 years of age.\nGrapefruit may interact with elagolix, estradiol, and norethindrone and lead to unwanted side effects. Avoid the use of grapefruit products.\n'),(649,'orlistat','Usual Adult Dose for Obesity:\n120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.\nUsual Pediatric Dose for Obesity:\n12 years or older:\n120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.\n Detailed Orlistat dosage information\n','Ask a doctor or pharmacist if it is safe for you to use orlistat if you are also using any of the following drugs:\namiodarone;\ncyclosporine;\ninsulin or oral diabetes medicine;\nHIV or AIDS medications;\nseizure medicine (especially if your seizures get worse while taking this medicine);\na vitamin or mineral supplement that contains beta-carotene or vitamin E; or\na blood thinner - warfarin, Coumadin, Jantoven.\nThis list is not complete. Other drugs may interact with orlistat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Orlistat drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to orlistat: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using orlistat and call your doctor at once if you have:\nsevere stomach pain;\nsevere pain in your lower back;\nblood in your urine, painful or difficult urination;\nsigns of kidney problems including little or no urinating; swelling in your feet or ankles; feeling tired or short of breath; or\nsigns of liver problems including nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nCommon orlistat side effects are caused by its fat-blocking action. These are signs that the medicine is working properly. These side effects are usually temporary and may lessen as you continue using this medicine:\noily or fatty stools;\noily spotting in your undergarments;\norange or brown colored oil in your stool;\ngas and oily discharge;\nloose stools, or an urgent need to go to the bathroom, inability to control bowel movements;\nan increased number of bowel movements; or\nstomach pain, nausea, rectal pain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Orlistat side effects (more detail)\n','Orlistat blocks some of the fat that you eat, keeping it from being absorbed by your body.\nOrlistat is used to aid in weight loss, or to help reduce the risk of regaining weight already lost. This medicine must be used together with a reduced-calorie diet and increased physical activity. Orlistat is for use only in adults that are overweight or obese.\nXenical is the prescription-strength form of orlistat. The Alli brand is available without a prescription.\n','Do not take orlistat if you are pregnant.\nYou should not use this medicine if you have a digestive disorder (problems absorbing food). You should not use Xenical if you have gallbladder problems, or if you are pregnant. Do not use Alli if you have had an organ transplant, if you use cyclosporine, or if you are not overweight.\nOrlistat is only part of a complete program of treatment that also includes diet, exercise, and weight control. Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely.\nAvoid a diet that is high in fat. High-fat meals taken in combination with orlistat can increase your risk of unpleasant side effects on your stomach or intestines.\nBefore taking this medicine\nYou should not use orlistat if you are allergic to it, if you have malabsorption syndrome (an inability to absorb food and nutrients properly), or if you are pregnant.\nYou also should not use Xenical if you have:\ngallbladder problems; or\nif you are pregnant.\nDo not use Alli if:\nyou are not overweight;\nyou have had an organ transplant; or\nyou are taking cyclosporine\nTo make sure orlistat is safe for you, tell your doctor if you have ever had:\nkidney stones;\ngallbladder disease;\npancreatitis;\nthyroid disease;\nliver disease;\nkidney disease; or\norgan transplant; or\nan eating disorder (anorexia or bulimia).\nDo not use orlistat if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight. Stop taking this medicine and tell your doctor right away if you become pregnant.\nTaking orlistat can make it harder for your body to absorb certain vitamins. These vitamins are important if you are nursing a baby. Do not use this medicine without a doctor\'s advice if you are breast-feeding a baby.\nXenical is not approved for use by anyone younger than 12 years old. Do not give Alli to anyone under 18 years old.\nHow should I take orlistat?\nUse orlistat exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.\nNever share orlistat with another person, especially someone with a history of eating disorders.\nRead all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.\nOrlistat is usually taken 3 times per day with each main meal that contains some fat (no more than 30% of the calories for that meal). You may take the medicine either with your meal or up to 1 hour after eating.\nIf you skip a meal or you eat a meal that does not contain any fat, skip your dose for that meal.\nThe fat content of your daily diet should not be greater than 30% of your total daily caloric intake. For example, if you eat 1200 calories per day, no more than 360 of those calories should be in the form of fat.\nRead the label of all food items you consume, paying special attention to the number of servings per container. Your doctor, nutrition counselor, or dietitian can help you develop a healthy eating plan.\nOrlistat is only part of a complete program of treatment that also includes diet and exercise. Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely.\nOrlistat can make it harder for your body to absorb certain vitamins, and you may need to take a vitamin and mineral supplement while you are taking this medicine. Follow your doctor\'s instructions about the type of supplement to use. Take the supplement at bedtime, or at least 2 hours before or after you take orlistat.\nStore at room temperature away from moisture, heat, and light. Keep the bottle tightly closed. Throw away any unused orlistat after the expiration date on the medicine label has passed.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember, but no more than 1 hour after eating a meal. If it has been more than an hour since your last meal, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Avoid eating high-fat meals or you could have unpleasant side effects on your stomach or intestines.\nIf you also take cyclosporine, do not take it within 3 hours before or 3 hours after you take orlistat.\nIf you also take levothyroxine (such as Synthroid), do not take it within 4 hours before or 4 hours after you take orlistat.\n'),(650,'orphenadrine','Usual Adult Dose for Muscle Spasm:\nExtended-Release Tablets: 100 mg orally twice a day Parenteral Injection: 60 mg IV or IM every 12 hours as needed Use: As an adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.\n Detailed Orphenadrine dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\n','Taking orphenadrine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.\nOther drugs may interact with orphenadrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Orphenadrine drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using orphenadrine and call your doctor at once if you have:\na light-headed feeling, like you might pass out;\npainful or difficult urination;\nlittle or no urination;\nconfusion, anxiety, agitation, tremors, hallucinations; or\npounding heartbeats or fluttering in your chest.\nCommon side effects may include:\ndizziness, drowsiness, weakness;\nnausea, vomiting;\ndry mouth; or\nconstipation.\nThis is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.\n Orphenadrine side effects (more detail)\n','Orphenadrine is a muscle relaxer.\nOrphenadrine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.\nOrphenadrine may also be used for purposes not listed in this medication guide.\n','You should not take  orphenadrine if you have urination problems, an enlarged prostate, glaucoma, a stomach ulcer or blockage in your digestive tract, trouble swallowing, or myasthenia gravis.\nBefore taking this medicine\nYou should not use orphenadrine if you are allergic to it, or if you have:\nurination problems;\nan enlarged prostate;\nglaucoma;\na stomach ulcer;\na blockage in your stomach or intestines;\ntrouble swallowing; or\nmyasthenia gravis.\nTo make sure orphenadrine is safe for you, tell your doctor if you have:\nheart disease;\na heart rhythm disorder;\ncoronary artery disease; or\nif you also use a narcotic (opioid) medication.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether orphenadrine passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.\nOrphenadrine is not approved for use by anyone younger than 18 years old.\nHow should I take orphenadrine?\nFollow all directions on your prescription label. Do not take  orphenadrine in larger or smaller amounts or for longer than recommended.\nOrphenadrine may be habit-forming. Never share orphenadrine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.\nOrphenadrine is usually taken 2 times per day, once in the morning and once in the evening. Follow your doctor\'s dosing instructions.\nDo not crush, chew, or break an extended-release tablet. Swallow it whole.\nOrphenadrine is only part of a complete program of treatment that may also include rest, physical therapy, or other pain relief measures.\nStore orphenadrine at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.\nKeep track of the amount of medicine used from each new bottle. Orphenadrine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n',' orphenadrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDo not drink alcohol. Dangerous side effects or death can occur.\n'),(651,'ortho-tri-cyclen','Usual Adult Dose of Ortho Tri-Cyclen for Contraception:\n1 tablet orally once a day\nUsual Adult Dose for Acne:\n1 tablet orally once a day\nComments: Not all preparations are indicated for the treatment of acne; the manufacturer product information should be consulted.\nUsual Pediatric Dose for Acne:\n15 years or older: 1 tablet orally once a day\n-Use should be reserved for the treatment of acne only if the patient desires an oral contraceptive for birth control.\nUse: For the treatment of moderate acne vulgaris in females at least 15 years of age with no know contraindications to oral contraceptive therapy and who have achieved menarche.\n Detailed Ortho Tri-Cyclen dosage information\nWhat happens if I miss a dose?\nFollow the instructions provided with your medicine. Missing an Ortho Tri-Cyclen pill increases your risk of becoming pregnant.\nIf you miss 1 active pill, take 2 pills on the day you remember. Then take 1 pill per day for the rest of the pack.\nIf you miss 2 active pills in a row in Week 1 or 2, take 2 pills per day for 2 days in a row. Then take 1 pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills.\nIf you miss 2 active pills in a row in Week 3, throw out the pack and start a new pack the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day.\nIf you miss 3 active pills in a row in Week 1, 2, or 3, throw out the pack and start a new pack on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day.\nIf you miss 2 or more pills, you may not have a period during the month. If you miss a period for 2 months in a row, call your doctor because you might be pregnant.\nIf you miss a reminder pill, throw it away and keep taking one reminder pill per day until the pack is empty.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs interact with ethinyl estradiol and norgestimate, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Ortho Tri-Cyclen drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Ortho Tri-Cyclen: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using Ortho Tri-Cyclen and call your doctor at once if you have:\nsigns of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;\nsigns of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;\nheart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;\nliver problems - loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nsevere headache, pounding in your neck or ears;\nswelling in your hands, ankles, or feet;\nchanges in the pattern or severity of migraine headaches;\na breast lump; or\nsymptoms of depression - sleep problems, weakness, tired feeling, mood changes.\nCommon Ortho Tri-Cyclen side effects may include:\nstomach pain, gas, nausea, vomiting;\nbreast tenderness;\nacne, darkening of facial skin;\nheadache, nervousness, mood changes;\nqa\nproblems with contact lenses;\nchanges in weight;\nbreakthrough bleeding;\nvaginal itching or discharge; or\nrash.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ortho Tri-Cyclen side effects (more detail)\n','Ortho Tri-Cyclen is a combination birth control pill containing the female hormones ethinyl estradiol and norgestimate. These hormones prevent ovulation (the release of an egg from an ovary).\nOrtho Tri-Cyclen also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.\nOrtho Tri-Cyclen is used as contraception to prevent pregnancy.\nOrtho Tri-Cyclen is also used to treat moderate acne vulgaris in females who are at least 15 years old. This medicine should be used for the treatment of acne only if the patient desires an oral contraceptive for birth control.\n','Do not use Ortho Tri-Cyclen if you are pregnant or if you have recently had a baby.\nYou should not use Ortho Tri-Cyclen if you have: uncontrolled high blood pressure, heart disease, coronary artery disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you also take certain hepatitis C medication, if you will have major surgery, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or birth control pills, or cancer of the breast, uterus/cervix, or vagina.\nTaking birth control pills can increase your risk of blood clots, stroke, or heart attack.\nSmoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take Ortho Tri-Cyclen if you smoke and are over 35 years old.\nBefore taking this medicine\nTaking Ortho Tri-Cyclen can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight. Your risk of stroke or blood clot is highest during your first year of taking birth control pills. Your risk is also high when you restart birth control pills after not taking them for 4 weeks or longer.\nSmoking can greatly increase your risk of blood clots, stroke, or heart attack. Your risk increases the older you are and the more you smoke. You should not take combination birth control pills if you smoke and are over 35 years old.\nDo not use Ortho Tri-Cyclen if you are pregnant. Stop using this medicine and tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills.\nYou should not take Ortho Tri-Cyclen if you have:\nuntreated or uncontrolled high blood pressure;\nheart disease (chest pain, coronary artery disease, history of heart attack, stroke, or blood clot);\nan increased risk of having blood clots due to a heart problem or a hereditary blood disorder;\ncirculation problems (especially if caused by diabetes);\na history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina;\nunusual vaginal bleeding that has not been checked by a doctor;\nliver disease or liver cancer;\nsevere migraine headaches (aura, numbness, vision changes), especially if you are older than 35; or\nif you take any hepatitis C medication containing ombitasvir/paritaprevir/ritonavir (Technivie).\nTo make sure Ortho Tri-Cyclen is safe for you, tell your doctor if you have ever had:\nheart problems, high blood pressure, or if you are prone to having blood clots;\nhigh cholesterol or triglycerides, or if you are overweight;\ndepression;\na seizure or migraine headache;\ndiabetes, gallbladder disease, underactive thyroid;\nliver or kidney disease;\njaundice caused by pregnancy or birth control pills;\nirregular menstrual cycles; or\nfibrocystic breast disease, lumps, nodules, or an abnormal mammogram.\nThis medicine can slow breast milk production. Tell your doctor if you are breast-feeding.\nHow should I take Ortho Tri-Cyclen?\nTake Ortho Tri-Cyclen exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nYou will take your first pill on the first day of your period or on the first Sunday after your period begins. You may need to use back-up birth control, such as condoms with spermicide, when you first start using Ortho Tri-Cyclen. Follow your doctor\'s instructions.\nTake one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not take one pill daily.\nOrtho Tri-Cyclen packs contain seven dark green \"reminder\" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills.\nYou may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy.\nUse a back-up birth control if you are sick with severe vomiting or diarrhea.\nIf you need major surgery with long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Ortho Tri-Cyclen.\nWhile taking Ortho Tri-Cyclen, you will need to visit your doctor regularly.\nStore this medicine at room temperature away from moisture and heat.\n','Do not smoke while taking Ortho Tri-Cyclen, especially if you are older than 35 years of age.\nOrtho Tri-Cyclen will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.\n'),(652,'oseltamivir','Take oseltamivir exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nStart taking this medicine as soon as possible after flu symptoms appear, such as fever, chills, muscle aches, sore throat, and runny or stuffy nose.\nTake the oseltamivir capsule with a full glass of water.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nOseltamivir may be taken with food if it upsets your stomach.\nTo treat flu symptoms: Take oseltamivir every 12 hours for 5 days.\nTo prevent flu symptoms: Take oseltamivir every 24 hours for 10 days or as prescribed. Follow your doctor\'s instructions.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nUse this medicine for the full prescribed length of time, even if your symptoms quickly improve. Tell your doctor if your symptoms do not improve, or if they get worse.\nStore oseltamivir capsules at room temperature away from moisture and heat.\nStore liquid medicine in the refrigerator but do not freeze. Throw away any unused liquid after 17 days.\nThe liquid may also be stored at cool room temperature for up to 10 days\n Detailed Oseltamivir dosage information\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 2 hours. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with oseltamivir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Oseltamivir drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to oseltamivir (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nSome people using oseltamivir (especially children) have had sudden unusual changes in mood or behavior. It is not certain that this medicine is the exact cause of these symptoms. Even without using oseltamivir, anyone with influenza can have neurologic or behavioral symptoms. Call your doctor right away if the person using this medicine has:\nsudden confusion;\ntremors or shaking;\nunusual behavior; or\nhallucinations (hearing or seeing things that are not there).\nCommon oseltamivir side effects may include:\nnausea, vomiting;\nheadache; or\npain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oseltamivir side effects (more detail)\n','Oseltamivir is an antiviral medication that blocks the actions of influenza virus types A and B in your body.\nOseltamivir is used to treat influenza in people 2 weeks of age and older who have had flu symptoms for 2 days or less. Oseltamivir may also be given to prevent influenza in people who may have been exposed but do not yet have symptoms. This medicine will not treat the common cold.\nIt is dangerous to purchase oseltamivir on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of \"Tamiflu\" purchased on the Internet have been found to contain cloxacillin, a type of antibiotic that can have dangerous side effects in people who are allergic to penicillin.\n','Oseltamivir is used to treat flu symptoms caused by influenza virus in patients who have had symptoms for less than 2 days. It may also be given to prevent influenza in people who may be exposed but do not yet have symptoms. This medicine will not treat the common cold.\nBefore taking this medicine, tell your doctor if you have received a nasal flu vaccine within the past 2 weeks, or if you have kidney disease, heart disease, lung disease, or any other serious disease or health problem. Also tell your doctor if you have any condition causing swelling or disorder of the brain.\nTake Oseltamivir for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.\nSome people using this medicine have had rare side effects of sudden confusion, delirium, hallucinations, unusual behavior, or self-injury. These symptoms have occurred most often in children. It is not known whether this medicine was the exact cause of these symptoms. However, anyone using this medicine should be watched closely for signs of confusion or unusual behavior. Call a doctor at once if you or the child using this medicine has any of these symptoms.\nBefore taking this medicine\nOseltamivir should not be used in place of getting a yearly flu shot. The Centers for Disease Control (CDC) recommends an annual flu shot to help protect you each year from new strains of influenza virus. You can get a flu shot even while using this medicine.\nYou should not use oseltamivir if you are allergic to it.\nDo not use oseltamivir to prevent influenza in a child younger than 3 months old. Do not use this medicine to treat influenza in a child younger than 2 weeks old unless instructed by your doctor.\nTell your doctor if you have ever had:\nkidney disease (or if you are on dialysis);\nheart disease or chronic lung disease;\na condition causing swelling or disorder of the brain;\na weak immune system (caused by disease or by using certain medicine);\nhereditary fructose intolerance; or\nif you have used a nasal flu vaccine (FluMist) within the past 2 weeks.\nIt is not known whether this medicine will harm an unborn baby. However, getting sick with influenza during pregnancy can cause complications leading to birth defects, low birth weight, preterm delivery, or stillbirth. Your doctor will decide whether you should receive oseltamivir if you are pregnant.\nThe Centers for Disease Control and Prevention (CDC) recommends that pregnant women may receive a yearly flu vaccine to prevent influenza. Oseltamivir is not to be used in place of the yearly flu shot.\nIt is not known whether oseltamivir passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\n','Do not use a nasal flu vaccine (FluMist) within 48 hours after taking this medicine. Oseltamivir may interfere with the drug action of FluMist, making the vaccine less effective. Follow your doctor\'s instructions.\n'),(653,'otezla','Usual Adult Dose for Psoriatic Arthritis:\nInitial dose:\n-Day 1: 10 mg orally once a day (AM)\n-Day 2: 10 mg orally twice a day (AM and PM)\n-Day 3: 10 mg orally once a day (AM); 20 mg orally once a day (PM)\n-Day 4: 20 mg orally twice a day (AM and PM)\n-Day 5: 20 mg orally once a day (AM); 30 mg orally once a day (PM)\nMaintenance dose: 30 mg orally twice a day (AM and PM)\nComments: This titration is intended to reduce the gastrointestinal symptoms associated with initial therapy.\nUse: Treatment of adult patients with active psoriatic arthritis\n Detailed Otezla dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may interact with apremilast, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Otezla drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Otezla: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere diarrhea, nausea, and vomiting;\nunexplained weight loss, or if you lose a lot of weight;\nmood changes, new or worsening depression; or\nthoughts of suicide or hurting yourself.\nCommon Otezla side effects may include:\nnausea, diarrhea;\nheadache; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Otezla side effects (more detail)\n','Otezla (apremilast) inhibits an enzyme within your immune system that can affect certain cells and contribute to inflammation in the body.\nOtezla is used to treat active psoriatic arthritis in adults.\nOtezla is also used to treat moderate to severe plaque psoriasis in adults who may also receive phototherapy or other treatments for psoriasis.\nOtezla is also used to treat mouth ulcers in adults with Behçet\'s disease (a disease causing inflammation in blood vessels).\n','When using Otezla your weight should be monitored regularly. Any unexplained or significant weight loss should be reported to your health care provider.\nContact your healthcare provider if you experience severe diarrhea, nausea, or vomiting.\nSome people have thoughts about suicide while taking Otezla. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nBefore taking this medicine\nYou should not use Otezla if you are allergic to apremilast.\nTo make sure Otezla is safe for you, tell your doctor if you have ever had:\nkidney disease; or\ndepression or suicidal thoughts or actions.\nSome people have thoughts about suicide while taking Otezla. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nApremilast may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of apremilast on the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nOtezla is not approved for use by anyone younger than 18 years old.\nHow should I take Otezla?\nTake Otezla exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nYou may take Otezla with or without food.\nSwallow the tablet whole and do not crush, chew, or break it.\nKeep track of your body weight while you are taking this medicine, and tell your doctor about any major weight loss.\nStore at room temperature away from moisture and heat.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(654,'oxaliplatin','Usual Adult Dose for Colorectal Cancer:\n85 mg/m2 via IV infusion over 120 minutes every 2 weeks; administer in combination with infusional 5-fluorouracil and leucovorin.Duration of Therapy: -Adjuvant Treatment of Stage III Colon Cancer: Total of 6 months (12 cycles)-Treatment of Advanced Colorectal Cancer: Until disease progression or unacceptable toxicityComments: -Premedication with antiemetics, including 5-HT3 blockers with or without dexamethasone, is recommended.-Consult the manufacturer product information for 5-fluorouracil and leucovorin dosing recommendations.Uses: In combination with infusional 5-fluorouracil and leucovorin:-Adjuvant treatment of Stage III colon cancer in patients who have undergone complete resection of the primary tumor.-Treatment of advanced colorectal cancer.\n Detailed Oxaliplatin dosage information\n','Other drugs may affect oxaliplatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Oxaliplatin drug interactions (more detail)\nDoes Oxaliplatin interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Oxaliplatin can cause a severe or life-threatening allergic reaction. Some people receiving a oxaliplatin injection have had a reaction to the infusion within minutes after the medicine is injected into the vein. Tell your caregiver right away if you feel dizzy, short of breath, confused, sweaty, itchy, or have diarrhea, chest pain, warmth or redness in your face, or feel like you might pass out.\nGet emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nincreased sensitivity to cold temperatures and cold objects;\nnumbness, tingling, or burning pain that interferes with daily activities;\nsevere or ongoing diarrhea or vomiting;\nconfusion, change in mental status, vision problems, seizure (convulsions);\npain or burning when you urinate;\nsudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;\npain, redness, swelling, or skin changes where the injection was given;\ndehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;\nheart problems--headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;\nliver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nmuscle problems--unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine;\nnerve problems--jaw or chest tightness, eye pain, strange feeling in your tongue, problems with speech or swallowing; or\nlow blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.\nCommon side effects may include:\nnausea, vomiting, diarrhea;\nnumbness, tingling, burning pain;\nlow blood cell counts;\nabnormal liver function tests;\nmouth sores; or\nfeeling tired.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxaliplatin side effects (more detail)\n','Oxaliplatin is used together with other cancer medications to treat colon and rectal cancer.\nOxaliplatin may also be used for purposes not listed in this medication guide.\n','Oxaliplatin can cause a severe or life-threatening allergic reaction. Get emergency medical help if you have: rash, hives, itching, sweating; chest pain, warmth or redness in your face, feeling light-headed; sudden cough, difficult breathing; swelling of your face, lips, tongue, or throat.\nBefore taking this medicine\nYou should not be treated with  oxaliplatin if you have ever had an allergic reaction to oxaliplatin or similar medications such as carboplatin (Paraplatin) or cisplatin (Platinol).\nTell your doctor if you have ever had:\nan active or recent infection;\nkidney disease;\nliver disease;\nheart disease, heart rhythm disorder;\nlong QT syndrome (in you or a family member);\nan electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood);\nbreathing disorder; or\na nerve problem.\nOxaliplatin can harm an unborn baby if the mother or the father is using this medicine.\nIf you are a woman, do not use oxaliplatin if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 9 months after your last dose.\nIf you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 6 months after your last dose.\nTell your doctor right away if a pregnancy occurs while either the mother or the father is using oxaliplatin.\nThis medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because oxaliplatin can harm an unborn baby.\nDo not breastfeed while using this medicine, and for at least 3 months after your last dose.\nHow is oxaliplatin given?\nOxaliplatin is given as an infusion into a vein. A healthcare provider will give you this injection.\nOxaliplatin must be given slowly, and the infusion can take at least 2 hours to complete.\nOxaliplatin is usually given once every 2 weeks. Your doctor will determine how long to treat you with this medicine.\nYou may be given medication to prevent nausea or vomiting.\nReceiving oxaliplatin can make you more sensitive to cold, which can cause numbness, tingling, and muscle spasms. This includes exposure to cold temperature and coming into contact with cold objects. To prevent discomfort, follow these steps:\ndo not inhale deeply when you are exposed to cold air;\ncover your skin, head, and face when you are outside in cold temperatures;\nwear gloves when handling cold objects or refrigerated foods;\ndo not run an air conditioner at very cool temperature in your home or car (even during hot weather);\ndo not drink cold drinks or use ice cubes in drinks;\ndo not put ice packs on your body.\nChemotherapy often causes nausea or mouth sores. Do not eat ice chips to ease these discomforts because you will be more sensitive to cold. Talk to your doctor about other ways to treat nausea or mouth sores. You may be given other medications to prevent nausea or vomiting while you are receiving oxaliplatin.\nOxaliplatin can lower your blood cell counts. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results.\nYour heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).\nWhat happens if I miss a dose?\nContact your doctor if you miss an appointment for your oxaliplatin injection.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Avoid cold temperatures and cold objects, including ice, cold drinks, and skin exposure to cold temperatures.\nAvoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.\n oxaliplatin may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.\n'),(655,'oxandrolone','Usual Adult Dose for Weight Loss:\n2.5 mg to 20 mg orally in 2 to 4 divided dosesDuration of therapy: 2 to 4 weeks, may be repeated intermittently as indicated.Uses:-Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight-To offset the protein catabolism associated with prolonged administration of corticosteroids-For the relief of the bone pain frequently accompanying osteoporosis\nUsual Geriatric Dose for Weight Loss:\n5 mg orally twice a dayUses:-Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight-To offset the protein catabolism associated with prolonged administration of corticosteroids-For the relief of the bone pain frequently accompanying osteoporosis\nUsual Pediatric Dose for Weight Loss:\nLess than or equal to 0.1 mg per kg body weight, may be repeated intermittently as indicated.Uses:-Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight-To offset the protein catabolism associated with prolonged administration of corticosteroids-For the relief of the bone pain frequently accompanying osteoporosis\n Detailed Oxandrolone dosage information\n','Other drugs may interact with oxandrolone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Oxandrolone drug interactions (more detail)\nDoes Oxandrolone interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nnew or worsening acne;\nshortness of breath (even with mild exertion), swelling in your ankles or feet, rapid weight gain;\nincreased or ongoing erection of the penis;\nunusual penis growth before puberty;\nimpotence, ejaculation problems, decreased amounts of semen, decrease in testicle size;\npainful or difficult urination;\nliver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or\nhigh levels of calcium in your blood--vomiting, stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless.\nWomen receiving oxandrolone may develop male characteristics, which could be irreversible if testosterone treatment is continued. Stop taking  oxandrolone and call your doctor at once if you notice any of these signs of excess testosterone:\nacne;\nchanges in menstrual periods;\nmale-pattern hair growth (such as on the chin or chest);\nhoarse or deepened voice; or\nenlarged clitoris.\nCommon side effects (in men or women) may include:\nbreast swelling;\nfeeling excited;\nsleep problems (insomnia); or\nincreased or decreased interest in sex.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxandrolone side effects (more detail)\n','Oxandrolone is a man-made steroid, similar to the naturally occurring steroid testosterone. Oxandrolone is an \"anabolic\" steroid that promotes the growth of muscle tissue.\nOxandrolone is used to help you regain weight lost after surgery, severe trauma, or chronic infections. Oxandrolone is also used in people who cannot gain or maintain a healthy weight for unknown medical reasons.\nOxandrolone is also used to decrease muscle loss caused by using steroid medicines, and to reduce bone pain in people with osteoporosis.\nOxandrolone may also be used for purposes not listed in this medication guide.\n','You should not use oxandrolone if you have prostate cancer, advanced kidney disease, high levels of calcium in your blood, breast cancer, or if you are pregnant.\nSome people using anabolic steroid medicine have developed life-threatening side effects on the liver, spleen, and blood vessels. These conditions can occur without warning or symptoms and can lead to liver failure, internal bleeding, cancer, stroke, heart attack, or death. Talk with your doctor about the risks and benefits of using  oxandrolone.\nBefore taking this medicine\nYou should not use oxandrolone if you are allergic to it, or if you have\nprostate cancer;\nadvanced kidney disease;\nhigh levels of calcium in your blood (hypercalcemia);\nbreast cancer (in men or in women who have hypercalcemia); or\nif you are pregnant.\nSome people using anabolic steroid medicine have developed cysts or tumors of the liver or spleen. These conditions can occur without warning or symptoms and can lead to liver failure, internal bleeding, cancer, or death. Using anabolic steroid medicine may also cause cholesterol (lipid) changes within your blood, which can increase fatty buildup inside your arteries (also called atherosclerosis). This condition can lead to stroke or heart attack. Talk with your doctor about the risks and benefits of using oxandrolone.\nTo make sure oxandrolone is safe for you, tell your doctor if you have:\nliver disease;\na history of heart disease;\nhigh cholesterol or triglycerides (a type of fat in the blood);\ndiabetes;\na thyroid disorder;\nchronic obstructive pulmonary disease (COPD);\na history of stroke or blood clots;\nif you take a blood thinner (warfarin, Coumadin, Jantoven); or\nif you use other steroid medicines (prednisone, methylprednisolone, and others).\nThis medicine can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Use effective birth control and tell your doctor right away if you become pregnant during treatment.\nIt is not known whether oxandrolone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.\nOlder men may have an increased risk of developing an enlarged prostate or prostate cancer while taking this medicine. Talk with your doctor about your individual risk.\nHow should I take oxandrolone?\nOxandrolone is usually given for only a few weeks. Follow all directions on your prescription label. Do not take  oxandrolone in larger or smaller amounts or for longer than recommended.\nOxandrolone will not enhance athletic performance and should not be used for that purpose.\nOxandrolone may be habit-forming. Never share oxandrolone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.\nIf a child is taking this medicine, tell your doctor if the child has any changes in weight. Oxandrolone doses are based on weight in children.\nWhile using oxandrolone, you will need frequent blood tests. Your kidney function may also need to be checked with urine tests.\nOxandrolone can cause bone overgrowth in children, especially young children. Bone development may need to be checked with x-rays every 6 months during treatment.\nStore at room temperature away from moisture and heat.\nKeep track of the amount of medicine used from each new bottle. Oxandrolone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(656,'oxazepam','Usual Adult Dose for Anxiety:\n10 to 15 mg orally, 3 or 4 times per dayUse: Management of mild-to-moderate anxiety, with associated tension, irritability, agitation, or related symptoms of functional origin or secondary to organic disease:15 to 30 mg orally, 3 or 4 times per dayUse: Management of severe anxiety syndromes, agitation, or anxiety associated with depression\nUsual Adult Dose for Alcohol Withdrawal:\n15 to 30 mg orally, 3 or 4 times per dayUse: Relief of symptoms in alcoholics with acute inebriation, tremulousness, or anxiety on withdrawal\nUsual Geriatric Dose for Anxiety:\n10 mg orally, 3 times per day; if needed, increase cautiously to 15 mg orally, 3 or 4 times per dayUse: Management of anxiety, tension, irritability, and agitation in older patients\nUsual Pediatric Dose for Anxiety:\n13 years and older:10 to 15 mg orally, 3 or 4 times per dayComments:-The absolute dosage for patients 6 to 12 years is not established.Use: Management of mild-to-moderate anxiety, with associated tension, irritability, agitation, or related symptoms of functional origin or secondary to organic disease:15 to 30 mg orally, 3 or 4 times per dayComments:-The absolute dosage for patients 6 to 12 years is not established.Use: Management of severe anxiety syndromes, agitation, or anxiety associated with depression\n Detailed Oxazepam dosage information\n','Taking oxazepam with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nOther drugs may affect oxazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Oxazepam drug interactions (more detail)\nDoes Oxazepam interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOxazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.\nCall your doctor at once if you have:\nsevere drowsiness;\na light-headed feeling, like you might pass out;\nunusual changes in mood or behavior;\nconfusion, anger, paranoia, problems with memory or concentration;\ntremors, slurred speech, problems with balance or muscle movement;\na seizure;\ntrouble breathing;\nfever, chills, sore throat; or\nupper stomach pain, dark urine, jaundice (yellowing of the skin or eyes).\nThe sedative effects of oxazepam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury.\nCommon side effects may include:\ndrowsiness;\ndizziness, spinning sensation; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxazepam side effects (more detail)\n','Oxazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat anxiety disorders.\nOxazepam may also be used short-term to treat symptoms of alcohol withdrawal.\nOxazepam may also be used for purposes not listed in this medication guide.\n','Oxazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing.\nMISUSE OF  oxazepam CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.\nDo not stop using oxazepam suddenly. Follow your doctor\'s instructions about tapering your dose.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to oxazepam, or if you have mental illness and psychosis.\nTell your doctor if you have ever had:\nlow blood pressure;\ndepression, mental illness, suicidal thoughts;\nalcoholism or drug addiction; or\nliver or kidney disease.\nTell your doctor if you are pregnant or plan to become pregnant. Oxazepam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.\nIf you use oxazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nOxazepam is not approved for use by anyone younger than 6 years old.\nHow should I take oxazepam?\nFollow the directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Never use oxazepam in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of  oxazepam.\nNever share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.\nWhile using oxazepam, you may need frequent blood tests.\nOxazepam should be used for only a short time. Do not take this medicine for longer than your doctor recommends.\nDo not stop using oxazepam suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor\'s instructions about tapering your dose.\nStore at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include extreme drowsiness, confusion, muscle weakness, or loss of consciousness.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or hazardous activity until you know how  oxazepam will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(657,'oxcarbazepine','Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nGive the liquid directly from the oral syringe, or mix the medicine with a small glass of water. After using the syringe, rinse it with water and allow it to air dry.\nTake the oxcarbazepine extended-release tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.\nYou may take the oxcarbazepine oral liquid or regular tablet with or without food.\nSwallow the extended-release tablet whole and do not crush, chew, or break it.\nYou may need frequent blood tests.\nDo not stop using oxcarbazepine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor\'s instructions about tapering your dose.\nIn case of emergency, wear or carry medical identification to let others know you use oxcarbazepine.\nSeizures are often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor\'s advice.\nStore at room temperature away from moisture and heat. Throw away any unused liquid 7 weeks after opening the bottle.\n Detailed Oxcarbazepine dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using oxcarbazepine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nSometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nMany drugs can affect oxcarbazepine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Oxcarbazepine drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSeek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.\nOxcarbazepine can reduce the sodium in your body to dangerously low levels, which can cause a life-threatening electrolyte imbalance. Call your doctor right away if you have nausea, lack of energy, confusion, feeling tired or irritable, severe weakness, muscle pain, or increased seizures.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.\nCommon side effects may include:\ndizziness, drowsiness, tiredness;\nbalance or coordination problems;\nnausea, vomiting;\ntremors or shaking;\ndouble vision; or\nrash.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxcarbazepine side effects (more detail)\n','Oxcarbazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain.\nOxcarbazepine is used either alone or with other medicines to treat partial seizures.\nThe Trileptal brand of oxcarbazepine is used as a single medicine in adults and children who are at least 4 years old. Trileptal is used with other medicines in adults and children who are at least 2 years old.\nThe Oxtellar XR brand of oxcarbazepine is used with other medicines in adults and children who are at least 6 years old.\nOxcarbazepine may also be used for purposes not listed in this medication guide.\n','Seek medical treatment if you have symptoms of a serious drug reaction: skin rash, fever, swollen glands, flu-like symptoms, unusual bruising or bleeding, or yellowing of your skin or eyes.\nCall your doctor right away if you have symptoms of low sodium levels in your body, such as nausea, confusion, severe weakness, muscle pain, or increased seizures.\nSome people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nDo not stop using oxcarbazepine suddenly.\nBefore taking this medicine\nYou should not take  oxcarbazepine if you are allergic to oxcarbazepine or eslicarbazepine.\nTell your doctor if you have ever had:\nliver disease;\nkidney disease;\nmood problems or suicidal thoughts; or\nan allergy to carbamazepine (Carbatrol, Tegretol).\nSome people have thoughts about suicide while taking oxcarbazepine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nDo not start or stop taking oxcarbazepine during pregnancy without your doctor\'s advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant while taking oxcarbazepine for seizures.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of oxcarbazepine on the baby.\nOxcarbazepine can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.\nYou should not breast-feed while you are taking oxcarbazepine.\nDo not give this medicine to a child without medical advice. There are specific age restrictions for the use of oxcarbazepine in children, depending on the dose form and whether it is used alone or with other medicines.\n','Do not drink alcohol. Drinking alcohol can increase certain side effects, and may increase the risk of seizures.\nAvoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor\'s instructions about the type and amount of liquids you should drink.\nAvoid driving or hazardous activity until you know how  oxcarbazepine will affect you. Your reactions could be impaired.\n'),(658,'oxybutynin','Take oxybutynin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nTake this medicine with a full glass of water, at the same time each day.\nOxybutynin may be taken with or without food.\nSwallow the extended-release tablet whole and do not crush, chew, or break it.\nMeasure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nSome tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.\nStore at room temperature away from moisture and heat.\n Detailed Oxybutynin dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using oxybutynin with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nTell your doctor about all your other medicines, especially:\nmedicine to treat depression, anxiety, mood disorders, or mental illness;\ncold or allergy medicine (Benadryl and others);\nmedicine to treat Parkinson\'s disease;\nmedicine to treat stomach problems, motion sickness, or irritable bowel syndrome;\nmedicine to treat overactive bladder; or\nbronchodilator asthma medication.\nThis list is not complete. Other drugs may interact with oxybutynin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Oxybutynin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to oxybutynin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using this medicine and call your doctor at once if you have:\nsevere stomach pain or constipation;\nblurred vision, tunnel vision, eye pain, or seeing halos around lights;\nlittle or no urination;\npainful or difficult urination; o\ndehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;\nSide effects such as dry mouth, constipation, and confusion may be more likely in older adults.\nCommon oxybutynin side effects may include:\ndizziness, drowsiness;\nblurred vision;\ndry mouth; or\ndiarrhea, constipation.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxybutynin side effects (more detail)\n','Oxybutynin reduces muscle spasms of the bladder and urinary tract.\nOxybutynin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination.\nOxybutynin may also be used for purposes not listed in this medication guide.\n','You should not use oxybutynin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate.\nBefore using oxybutynin, tell your doctor if you have glaucoma, liver or kidney disease, an enlarged prostate, myasthenia gravis, ulcerative colitis, a blockage in your stomach or intestines, or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion.\nAvoid becoming overheated or dehydrated during exercise and in hot weather. Oxybutynin can decrease perspiration and you may be more prone to heat stroke.\nThis medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.\nThere are many other medicines that can interact with oxybutynin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.\nStop using this medication and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating.\nBefore taking this medicine\nYou should not use this medication if you are allergic to oxybutynin, or if you have:\nuntreated or uncontrolled narrow-angle glaucoma;\na blockage in your digestive tract (stomach or intestines); or\nif you are unable to urinate.\nTo make sure oxybutynin is safe for you, tell your doctor if you have:\nglaucoma;\nliver disease;\nkidney disease;\nan enlarged prostate;\nulcerative colitis;\nParkinson\'s disease;\na nerve disorder that affects your heart rate, blood pressure, or digestion;\na muscle disorder such as myasthenia gravis; or\na stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion.\nTell your doctor if you are pregnant or breastfeeding.\n','Avoid driving or hazardous activity until you know how oxybutynin will affect you. Your reactions could be impaired.\nAvoid becoming overheated or dehydrated during exercise and in hot weather. Oxybutynin can decrease sweating and you may be more prone to heat stroke.\nDrinking alcohol with this medicine can increase side effects.\n'),(659,'oxycodone','Take oxycodone exactly as prescribed. Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of oxycodone.\nNever share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.\nStop taking all other around-the-clock opioid pain medicines when you start taking extended-release oxycodone.\nTake with food.\nSwallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.\nIf you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use.\nNever crush or break an oxycodone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.\nMeasure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nYou should not stop using oxycodone suddenly. Follow your doctor\'s instructions about gradually decreasing your dose.\nStore at room temperature, away from heat, moisture, and light. Keep track of your medicine. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nDo not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.\n Detailed Oxycodone dosage information\nWhat happens if I miss a dose?\nSince oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.\nYour doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don\'t wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.\nAnyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nOpioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\nother opioids - opioid pain medicine or prescription cough medicine;\nsedative medications including alprazolam or Xanax, clonazepam or Klonopin, diazepam or Valium, lorazepam or Ativan, temazepam or Restoril and others;\nsleeping pills;\nmuscle relaxants or tranquilizers;\nmedicine for depression, anxiety, or other mental illness;\nmedicine for Parkinson’s disease;\nmigraine headache treatment; or\nmedications used for the prevention of nausea and vomiting.\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nThis list is not complete and many other drugs may interact with oxycodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Oxycodone drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to oxycodone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine, including oxycodone, can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nnoisy breathing, sighing, shallow breathing, breathing that stops during sleep;\na slow heart rate or weak pulse;\ncold, clammy skin;\na light-headed feeling, like you might pass out;\nconfusion, unusual thoughts or behavior;\nseizure (convulsions);\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or\nhigh levels of serotonin in the body - agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.\nSerious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.\nLong-term use of opioid medication, such as oxycodone, may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.\nCommon oxycodone side effects may include:\ndrowsiness, dizziness, tiredness;\nheadache;\nconstipation, stomach pain, nausea, vomiting; or\nitching, red eyes, or flushing.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxycodone side effects (more detail)\n','Oxycodone is an opioid pain medication sometimes called a narcotic.\nOxycodone is used to treat moderate to severe pain.\nThe extended-release form of oxycodone is for around-the-clock treatment of pain and should not be used on an as-needed basis for pain.\n','You should not use oxycodone if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.\nMISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.\nTaking oxycodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nOxycodone can slow or stop your breathing. This is more likely in elderly or ill patients, but can occur in anyone taking this medicine.\nBefore taking this medicine\nYou should not use oxycodone if you are allergic to it, or if you have:\nsevere asthma or breathing problems; or\na blockage in your stomach or intestines.\nYou should not use this medicine if you are already using a similar opioid medicine and are tolerant to it. Do not use this medicine if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine or have received a methylene blue injection.\nMost brands of oxycodone are not approved for use in people under the age of 18. OxyContin should not be given to a child younger than 11 years old.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea;\na head injury, brain tumor, or seizures;\ndrug or alcohol addiction, or mental illness;\nlung disease;\nliver or kidney disease;\nthyroid disorder;\nadrenal disease (such as Addison\'s disease;\nurination problems; or\nproblems with your gallbladder or pancreas.\nIf you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Tell your doctor if you are pregnant before using oxycodone. If you become pregnant while taking oxycodone, do not stop your medication suddenly without talking to your doctor. You may need to decrease your medicine gradually.\nAsk a doctor before using oxycodone if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.\nAvoid medication errors. Always check the brand and strength of oxycodone you get from the pharmacy.\n'),(660,'oxycontin','Take OxyContin exactly as prescribed. Follow the directions on your prescription label and read all medication guides. Never use oxycodone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of oxycodone.\nNever share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.\nStop taking all other around-the-clock opioid pain medicines when you start taking extended-release OxyContin.\nSwallow the extened release tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, or dissolve.\nNever crush or break an OxyContin tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This can result in death.\nYou should not stop using OxyContin suddenly. Follow your doctor\'s instructions about tapering your dose.\nStore at room temperature, away from heat, moisture, and light. Keep track of your medicine. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nDo not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.\n Detailed OxyContin dosage information\nWhat happens if I miss a dose?\nSince OxyContin is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.\nYour doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don\'t wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.\nAnyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nOpioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother opioids - opioid pain medicine or prescription cough medicine;\na sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;\ndrugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or\ndrugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete and many other drugs may interact with oxycodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n OxyContin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to OxyContin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nnoisy breathing, sighing, shallow breathing, breathing that stops during sleep;\na slow heart rate or weak pulse;\na light-headed feeling, like you might pass out;\nconfusion, unusual thoughts or behavior;\nseizure (convulsions);\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or\nhigh levels of serotonin in the body - agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.\nSerious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.\nLong-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.\nCommon OxyContin side effects may include:\ndrowsiness, headache, dizziness, tiredness; or\nconstipation, stomach pain, nausea, vomiting.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n OxyContin side effects (more detail)\n','OxyContin (oxycodone) is an opioid pain medication sometimes called a narcotic.\nOxyContin is a strong prescription medicine used when an opioid medicine is needed to manage severe pain enough to require daily around-the-clock, long-term treatment with an opioid, when other pain treatments such as non-opioid pain medicines or immediate-release opioid medicines do not treat your pain well enough or you cannot tolerate them.\nOxyContin is not to be used on an as-needed basis for pain that is not around-the-clock.\n','You should not use OxyContin if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.\nMISUSE OF OXYCONTIN CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.\nTaking oxycodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use OxyContin with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore taking this medicine\nYou should not use OxyContin if you are allergic to oxycodone, or if you have:\nsevere asthma or breathing problems; or\na blockage in your stomach or intestines.\nYou should not use OxyContin unless you are already using a similar opioid medicine and are tolerant to it.\nOxyContin should not be given to a child younger than 11 years old.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea;\na head injury, or seizures;\ndrug or alcohol addiction, or mental illness;\nliver or kidney disease;\nurination problems; or\nproblems with your gallbladder, pancreas, or thyroid.\nIf you use OxyContin while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.\nAsk a doctor before using oxycodone if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or operating machinery until you know how oxycodone will affect you. Dizziness or severe drowsiness can cause falls or other accidents.\nAvoid medication errors. Always check the brand and strength of oxycodone you get from the pharmacy.\n'),(661,'oxymetazoline','Administration\nAdminister topically to nasal mucosa or conjunctiva.  \nIntranasal Administration\nAdminister nasal solution intranasally as sprays or nasal pumps.\nPrior to initial use of metered sprays, prime nasal inhaler by depressing the pump firmly several times.\nAdminister nasal spray or pump into each nostril while head is erect.\nOphthalmic Administration\nAdminister ophthalmic solution topically to the conjunctiva. \nAvoid contamination of the dropper tip.\nRemove contact lenses before administering ophthalmic solution. \nDo not administer discolored or cloudy solutions.\nDosage\nAvailable as oxymetazoline hydrochloride; dosage expressed in terms of the salt. \nPediatric Patients\nNasal Congestion\nIntranasal\nFor self-medication in children ≥6 years of age: 2 or 3 sprays of a 0.05% nasal solution in each nostril every 10–12 hours (usually in the morning and evening), up to 2 times daily. \nConjunctival Congestion\nOphthalmic\nFor self-medication in children ≥6 years of age: 1 or 2 drops of a 0.025% ophthalmic solution in the affected eye(s) every 6 hours as needed.\nAdults\nNasal Congestion\nIntranasal\nFor self-medication: 2 or 3 sprays of a 0.05% nasal solution in each nostril every 10–12 hours (usually in the morning and evening), up to 2 times daily. \nConjunctival Congestion\nOphthalmic\nFor self-medication: 1 or 2 drops of a 0.025% ophthalmic solution in the affected eye(s) every 6 hours as needed.\nPrescribing Limits\nPediatric Patients\nNasal Congestion\nIntranasal\nSelf-medication in children ≥6 years of age: Maximum of 2 times (2 doses) in a 24-hour period. (See Advice to Patients.)\nAdults\nNasal Congestion\nIntranasal\nSelf-medication: Maximum of 2 times (2 doses) in a 24-hour period. (See Advice to Patients.)\n',NULL,NULL,'Nasal Congestion\nSelf-medication for temporary relief of nasal congestion associated with the common cold, hay fever, or other upper respiratory allergies.\nAs effective as other topical vasoconstrictors.\nLabeled and has been used for self-medication for temporary relief of nasal congestion associated with sinusitis;  however, efficacy data are lacking and/or controversial.   In October 2005, FDA issued final rule to remove this indication from labeling of OTC nasal decongestants. Compliance date for preparations with annual sales <$25,000 is October 11, 2007; compliance date for all other preparations is April 11, 2007.\nConjunctival Congestion\nSelf-medication for temporary relief of ocular redness due to minor irritation.\nOtitic Barotrauma\nHas been used for self-medication for symptomatic prevention of otitic barotrauma† (aerotitis [barotitis] media);   however, no more effective than placebo.\n',NULL,NULL),(662,'oxymetazoline-nasal','Usual Adult Dose for Nasal Congestion:\n2 or 3 sprays in each nostril not more often than every 10 to 12 hoursComments:-Do not exceed 2 doses in any 24-hour period.Uses: Temporary relief of nasal congestion due to common cold, hay fever, andupper respiratory allergies\nUsual Pediatric Dose for Nasal Congestion:\n6 years or older:2 or 3 sprays in each nostril not more often than every 10 to 12 hoursComments:-Do not exceed 2 doses in any 24-hour period.-Children ages 6 to under 12 years of age should use this drug with adult supervision.Uses: Temporary relief of nasal congestion due to common cold, hay fever,upper respiratory allergies\n Detailed Oxymetazoline nasal dosage information\n','Ask a doctor or pharmacist if it is safe for you to use oxymetazoline nasal if you are also using any of the following drugs:\nan antidepressant--amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline;\nergot medicine--ergotamine, dihydroergotamine, ergonovine, methylergonovine; or\nan MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine.\nThis list is not complete and other drugs may interact with oxymetazoline nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.\n Oxymetazoline nasal drug interactions (more detail)\nDoes Oxymetazoline nasal interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using oxymetazoline nasal and call your doctor at once if you have:\nongoing or worsening symptoms;\nsevere burning or stinging in your nose after using the nasal spray;\nchest pain, fast or uneven heart rate; or\nsevere headache, buzzing in your ears, anxiety, confusion, or feeling short of breath.\nCommon side effects may include:\nmild burning or stinging of the nose;\nsneezing; or\nrunny nose.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Oxymetazoline nasal side effects (more detail)\n','Oxymetazoline is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).\nOxymetazoline nasal (for the nose) is for temporary relief of nasal congestion (stuffy nose) caused by allergies or the common cold.\nOxymetazoline nasal may also be used for purposes not listed in this medication guide.\n','Oxymetazoline nasal (for the nose) is used for temporary relief of nasal congestion caused by allergies or the common cold.\nStop using  oxymetazoline nasal and call your doctor at once if you have ongoing or worsening symptoms, or if you have severe burning or stinging in your nose after using the nasal spray\nBefore taking this medicine\nYou should not use oxymetazoline nasal if you are allergic to it.\nAsk a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:\nheart disease, high blood pressure, coronary artery disease;\ndiabetes;\na thyroid disorder; or\nenlarged prostate or urination problems.\nFDA pregnancy category C. It is not known whether oxymetazoline nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.\nIt is not known whether oxymetazoline nasal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nHow should I use oxymetazoline nasal?\nUse exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.\nUsing the medication too long or too often may worsen your symptoms or cause nasal congestion to clear up and come back.\nCall your doctor if your symptoms do not improve after 3 days of treatment.\nDo not share this medication with another person, even if they have the same symptoms you have. Sharing a nasal spray bottle can spread infection.\nTo use the nose drops (nasal solution):\nBlow your nose gently. Tilt your head back as far as possible, or lie down and hang your head over the side of a bed. Hold the dropper over your nose and place the correct number of drops into your nose.\nSit up and bend your head slightly forward, then move it gently left and right. Stay seated with your head bent forward for a few minutes.\nAvoid sneezing or blowing your nose for at least a few minutes after using the nose drops.\nTo use the nasal spray:\nBlow your nose gently. Keep your head upright and insert the tip of bottle into one nostril. Press your other nostril closed with your finger. Breathe in quickly and gently spray the medicine into your nose. Then use the spray in your other nostril.\nDo not blow your nose for at least a few minutes after using the nasal spray.\nDo not use the nasal spray more than 2 times in 24 hours.\nWipe the tip of the spray bottle with a clean tissue but do not wash with water or soap.\nStore at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.\nWhat happens if I miss a dose?\nUse the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\nKeep  oxymetazoline nasal out of the reach of children. Certain nasal medications can cause serious medical problems in a young child who accidentally sucks on or swallows medicine from the nasal spray bottle.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),