Siponimod can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Tell your doctor about all your other medicines, especially:
drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection; or
other medicines to treat MS symptoms (a beta interferon, glatiramer, Avonex, Betaseron, Copaxone, Extavia, Glatopa, Rebif).
This list is not complete and many other drugs may interact with siponimod. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Siponimod can have long lasting effects on your body, especially on your immune system. For 3 or 4 weeks after your last dose, tell any doctor who treats you that you have used Mayzent.
 Mayzent drug interactions (more detail)
