Using vilazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your current medicines. Many drugs can affect vilazodone, especially:
any other antidepressants;
mephenytoin;
St. John's wort;
tramadol;
a diuretic or "water pill";
medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
a blood thinner--warfarin, Coumadin, Jantoven; or
migraine headache medicine--sumatriptan, Imitrex, Maxalt, Treximet, and others.
This list is not complete and many other drugs may affect vilazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Vilazodone drug interactions (more detail)
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