Get emergency medical help if you have any of these signs of an allergic reaction to Xiaflex: hives; chest pain, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Xiaflex can damage a nerve, tendon, or ligament in the hand the medicine is injected into. After the swelling from your injection goes down, call your doctor if you have:
numbness, tingling, increased pain;
trouble bending your finger toward your wrist; or
new or worsened movement problems in your treated hand.
Xiaflex may also damage the erectile tissues inside a man's penis, which could require surgery to correct. Call your doctor right away if you have:
bruising and swelling of your penis;
pain when you urinate, blood in the urine;
sudden erection problems; or
a "popping" sound or sensation in your penis during an erection.
Also call your doctor at once if you have:
signs of infection such as fever, chills, redness or swelling;
severe pain, itching, or other irritation; or
feeling like you might pass out (even while lying down).
Common Xiaflex side effects may include:
swelling, bruising, bleeding, pain, or tenderness where the medicine was injected;
swollen glands in your elbow or underarm;
itching, redness, or warmth of the skin;
cracked skin;
underarm pain;
mild pain or tenderness in your treated hand;
bruising of the penis or scrotum, erection problems; or
discoloration of the skin on your penis, bruising or blisters where Xiaflex was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Xiaflex side effects (more detail)
What other drugs can affect Xiaflex?
Other drugs may interact with collagenase clostridium histolyticum, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
