You should not use  hydrochlorothiazide and losartan if you are unable to urinate.
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.
If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren (a blood pressure medicine).
Before taking this medicine
You should not use this medicine if you are allergic to hydrochlorothiazide or losartan, if you are unable to urinate.
If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking hydrochlorothiazide and losartan with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
lupus;
liver or kidney disease;
asthma or allergies;
diabetes;
gout;
congestive heart failure;
glaucoma;
low or high levels of potassium in your blood;
high cholesterol or triglyceride levels; or
an allergy to penicillin or sulfa drugs.
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while using this medicine.
Hydrochlorothiazide and losartan is not approved for use by anyone younger than 18 years old.
How should I take hydrochlorothiazide and losartan?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Your blood pressure will need to be checked often.
Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking  hydrochlorothiazide and losartan. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and losartan.
If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
