Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people taking high doses of tofacitinib have developed serious or fatal blood clots. Stop taking Xeljanz XR and seek emergency medical attention if you have:
sudden shortness of breath;
pain while breathing;
cough with pink or red mucus;
pain in your chest or back;
clammy or blue-colored skin, heavy sweating; or
pain, swelling, or redness in an arm or a leg.
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:
fever, chills, sweating, tiredness, muscle pain;
feeling short of breath;
skin sores with warmth, redness, or swelling;
increased urination, pain or burning when you urinate;
mouth sores, stomach pain, diarrhea; or
signs of tuberculosis: fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired.
Further doses may be delayed until your infection clears up.
Also call your doctor at once if you have:
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;
signs of hepatitis--loss of appetite, vomiting, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
signs of shingles--flu-like symptoms, tingly or painful blistering rash on one side of your body; or
signs of perforation (a hole or tear) in your stomach or intestines--fever, ongoing stomach pain, change in bowel habits.
Common side effects may include:
skin rash, shingles;
increased blood pressure;
abnormal blood tests;
fever;
headache;
nausea, vomiting, diarrhea; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Xeljanz XR side effects (more detail)
