You should not use Zosyn if you have ever had an allergic reaction to certain antibiotics (especially a penicillin antibiotic).
Before using Zosyn tell your doctor if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, cystic fibrosis, a history of allergies, if you are on a low-salt diet, or if you are allergic to a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.
Use Zosyn for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Zosyn will not treat a viral infection such as the common cold or flu.
Zosyn may cause bleeding, especially in people with kidney disease or using certain medicines. Tell your doctor if you are using any medication to prevent blood clots such as alteplase (Activase), bivalirudin (Angiomax), clopidogrel (Plavix), dabigatran (Pradaxa), dipyridamole (Persantine, Aggrenox), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, tenecteplase (TNKase), ticlopidine (Ticlid), tinzaparin (Innohep), warfarin (Coumadin, Jantoven), and others.
Before taking this medicine
You should not use Zosyn if you are allergic to:
piperacillin or any other penicillin antibiotic (amoxicillin, ampicillin, Augmentin, dicloxacillin, oxacillin, penicillin, ticarcillin, or others);
tazobactam; or
a cephalosporin antibiotic such as cefdinir (Omnicef), cephalexin (Keflex), or others.
Tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
a bleeding or blood clotting disorder;
an electrolyte imbalance such as low levels of potassium in your blood;
cystic fibrosis;
any type of allergy; or
if you are on a low-salt diet.
Tell your doctor if you are pregnant or breastfeeding.
