Get emergency medical help if you have signs of an allergic reaction to Depo-Provera: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
menstrual periods that are heavier or longer than normal;
severe pain in your lower stomach;
swelling in your face, or your hands, ankles, and feet;
pain, bleeding, oozing (pus), or skin changes where the injection was given;
symptoms of depression (sleep problems, weakness, mood changes);
liver problems - upper stomach pain, itching, tiredness, dark urine, jaundice (yellowing of the skin or eyes); or
signs of a blood clot - sudden numbness or weakness, severe headache, chest pain, sudden cough, coughing up blood; problems with vision or speech, swelling or pain in an arm or leg.
Common Depo-Provera side effects may include:
changes in your menstrual periods;
weakness, feeling tired;
stomach pain;
feeling nervous;
decreased sexual drive;
weight gain;
headache, dizziness; or
lumps or dimpling in your skin where injections were given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Depo-Provera side effects (more detail)
