You may not be able to take  eplerenone if you have severe kidney disease, high potassium levels in your blood, or type 2 diabetes with increased levels of albumin (a protein) in your urine.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
You may not be able to take this medicine if you are allergic to eplerenone, or if you have:
high potassium levels in your blood (hyperkalemia);
severe kidney disease; or
type 2 diabetes with increased levels of albumin (a protein) in your urine.
Some medicines can cause unwanted or dangerous effects when used with eplerenone. Your doctor may change your treatment plan if you also use:
nefazodone;
a potassium supplement;
an antibiotic--clarithromycin, telithromycin;
antifungal medicine--itraconazole, ketoconazole;
a diuretic or "water pill"--amiloride, spironolactone, triamterene; or
antiviral medicine to treat HIV/AIDS--indinavir, nelfinavir, ritonavir, saquinavir.
Tell your doctor if you have ever had:
kidney disease;
diabetes;
liver disease;
high cholesterol or triglycerides; or
if you take other heart or blood pressure medications.
Tell your doctor if you are pregnant or breastfeeding.
It is not known whether eplerenone will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). Heart failure can get worse during pregnancy and may cause complications such as premature birth. The benefit of treating hypertension or heart failure may outweigh any risks to the baby.
This medicine may affect fertility (ability to have children) in men.
How should I take eplerenone?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Eplerenone may be taken with or without food.
You may need blood tests, and your blood pressure will need to be checked often.
If you have high blood pressure, keep using  eplerenone even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
