Get emergency medical help if you have signs of an allergic reaction to minocycline (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This may be more likely with long-term use of minocycline, and the reaction may occur several weeks after you began using this medicine.
Call your doctor at once if you have:
little or no urination, swelling in your feet or ankles, feeling tired or short of breath (signs of kidney problems);
loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, loss of appetite, easy bruising or bleeding, dark urine, yellowing of the skin or eyes (signs of liver or pancreas problems);
joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color;
severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes; or
swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, chest pain, new or worsening cough with fever, trouble breathing.
Common minocycline side effects may include:
numbness, tingling, burning pain;
hair loss;
discoloration of you skin or nails.
dizziness, spinning sensation;
muscle or joint pain;
nausea, diarrhea, loss of appetite;
swollen tongue, cough, trouble swallowing;
rash, itching; or
headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Minocycline side effects (more detail)
