Usual Adult Dose of Apokyn for Parkinson's Disease:
Dose initiation should be supervised by a healthcare provider: Antiemetic premedication should be initiated prior to therapy due to high incidence of nausea and vomiting
Initial dose: 2 mg (0.2 mL) subcutaneously during an "off" episode
-First dose: Obtain pulse, supine and standing blood pressure pre-dose, 20, 40, and 60 minutes post-dose; if significant hypotension is present 60 minutes post-dose, recheck after 60 minutes; if significant hypotension occurs in response to initial dose, patients should not be considered good candidates for treatment
-Titration: If initial dose is tolerated, but response is insufficient, may increase in 2 mg increments up to 6 mg (under medical supervision) or in increments of 1 mg every few days up to 3 mg (outpatient) for subsequent "off" episodes; allow at least 2 hours between doses; assess response until an effective and tolerable dose is achieved
Maintenance dose: 2 to 6 mg subcutaneously during an "off" episode; doses should be separated by at least 2 hours; average dosing frequency in clinical trials was 3 times per day
Maximum single dose: 6 mg (0.6 mL)
Maximum dosing frequency: 5 times per day
Maximum daily dose: 20 mg (2 mL) per day
 Detailed Apokyn dosage information
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
