Usual Adult Dose of Xywav for Narcolepsy:
Initial dose: 4.5 g orally per day, divided and given as 2 equal doses of up to 2.25 g/dose
Maintenance dose: The dose may be increased by 1.5 g (OR 0.75 g/dose) orally per night in weekly intervals up to 6 to 9 g/day.
Maximum dose: 9 g/day
Comments:
-Both doses should be diluted at the same time at night.
-The first dose should be taken at bedtime and the other dose should be taken between 2.5 to 4 hours after; some may need to set an alarm to awaken to take the second dose.
-Patients should remain in bed after taking each dose.
-If the second dose is missed, patients should skip the dose and should not take this drug until the next night.
-Dosing may be gradually titrated, and doses should be determined by efficacy and tolerability.
Usual Pediatric Dose of Xywav for Narcolepsy:
7 years and older:
Less than 20 kg: Specific dosing recommendations are not available.
20 to less than 30 kg:
-Initial dose: Up to 2 g orally per day, divided and given as 2 equal doses of up to 1 g/dose
-Maintenance dose: The dose may be increased by 1 g (OR 0.5 g/dose) orally per night at 1 to 2-week intervals up to 6 g/day.
-Maximum dose: 6 g/day
30 to less than 45 kg:
-Initial dose: Up to 3 g orally per day, divided and given as 2 equal doses of up to 1.5 g/dose
-Maintenance dose: The dose may be increased by 1 g (OR 0.5 g/dose) orally per night at 1 to 2-week intervals up to 7.5 g/day.
-Maximum dose: 7.5 g/day
45 kg and greater:
-Initial dose: Up to 4.5 g orally per day, divided and given as 2 equal doses of up to 2.25 g/dose
-Maintenance dose: The dose may be increased by 1.5 g (OR 0.75 g/dose) orally per night at 1 to 2-week intervals up to 9 g/day.
-Maximum dose: 9 g/day
Comments:
-Patients who sleep more than 8 hours/night may be given the first dose at bedtime or after an initial period of sleep.
-Patients weighing less than 20 kg may be given lower initial, maximum, maintenance, and total maximum nightly doses.
-Unequal doses may be required in some patients to attain an optimal response to treatment.
-Both doses should be diluted at the same time at night.
-The first dose should be taken at bedtime and the other dose should be taken between 2.5 to 4 hours after; some may need to set an alarm to awaken to take the second dose.
-Patients should remain in bed after taking each dose.
-If the second dose is missed, patients should skip the dose and should not take this drug until the next night.
-Dosing may be gradually titrated, and doses should be determined by efficacy and tolerability.
 Detailed Xywav dosage information
What happens if I miss a dose?
If you miss the second dose, skip that dose and take your regular doses the following night. Do not take two doses at one time.
Take Xywav only during your normal sleeping hours (wait at least 2 hours after eating).
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Xywav can be fatal.
Overdose symptoms may include sweating, vomiting, severe confusion, loss of balance or coordination, or seizure (convulsions).
