Usual Adult Dose of depo-subQ provera 104 for Endometriosis:
104 mg subcutaneously once every 3 months (12 to 14 weeks)
Duration of therapy: No longer than two years
Comments:
-For sexually active women having regular menses, the first injection should only be given within the first 5 days of a normal menstrual period or at 6 weeks postpartum, if the patient is breast feeding.
-If the period between injections is more than 14 weeks, pregnancy should be ruled out prior to administering.
-The impact of long-term use of the subcutaneous injection on bone mineral density (BMD) should be considered.
-If symptoms return after discontinuation of treatment, BMD should be evaluated prior to retreatment.
Use: Management of endometriosis-associated pain
Usual Adult Dose of Depo-Provera for Contraception:
Intramuscular injection:
-150 mg once every 3 months (13 weeks) in the gluteal or deltoid muscle
Subcutaneous injection:
-104 mg once every 3 months (12 to 14 weeks) into the anterior thigh or abdomen
First injection:
-Ensure the patient is not pregnant at the time of the first injection.
-The first injection should be given only during the first 5 days of a normal menstrual period, within the first 5-days postpartum if not breast-feeding, and at the sixth postpartum week if breast-feeding.
Switching from other methods of contraception:
-IM injection: The first injection should be given on the day after the last active contraception tablet, or at the latest, on the day following the final inactive contraception tablet.
-SC injection: The first injection should be given within 7 days after the last day taking the last active contraceptive tablet, or after removing the patch or ring. Similarly, contraceptive coverage will be maintained when switching from 150 mg IM injection, provided the next injection is given within the prescribed dosing period for the IM injection.
Comments:
-If the time interval between injections is greater than 13 weeks, pregnancy should be excluded before administering the drug.
-The efficacy of the IM suspension depends on adherence to the dosage schedule of administration.
-The risk/benefit of loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, should be assessed when using this IM injection long-term.
Use: Prevention of pregnancy in women of child bearing potential
Usual Pediatric Dose of Depo-Provera for Contraception:
Postmenarchal children and adolescents:
Intramuscular injection:
-150 mg once every 3 months (13 weeks) in the gluteal or deltoid muscle
Subcutaneous injection:
-104 mg once every 3 months (12 to 14 weeks) into the anterior thigh or abdomen
First injection:
-Ensure the patient is not pregnant at the time of the first injection.
-The first injection should be given only during the first 5 days of a normal menstrual period, within the first 5-days postpartum if not breast-feeding, and at the sixth postpartum week if breast-feeding.
Switching from other methods of contraception:
-IM injection: The first injection should be given on the day after the last active contraception tablet, or at the latest, on the day following the final inactive contraception tablet.
-SC injection: The first injection should be given within 7 days after the last day taking the last active contraceptive tablet, or after removing the patch or ring. Similarly, contraceptive coverage will be maintained when switching from 150 mg IM injection, provided the next injection is given within the prescribed dosing period for the IM injection.
Comments:
-If the time interval between injections is greater than 13 weeks, pregnancy should be excluded before administering the drug.
-The efficacy of the IM suspension depends on adherence to the dosage schedule of administration.
-The risk/benefit of loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, should be assessed when using the injection long-term.
Use: Prevention of pregnancy in women of child bearing potential
 Detailed Depo-Provera dosage information
What happens if I miss a dose?
Depo-Provera will not be effective in preventing pregnancy if you do not receive an injection every 3 months.
If you plan to continue using Depo-Provera, get the missed injection as soon as possible. Use a non-hormonal back-up birth control (such as a condom or diaphragm with spermicide) until you receive the missed injection.
You may need to have a negative pregnancy test before you receive a missed injection.
If more than 14 weeks have passed since your last injection, you may be able to get pregnant. The longer you wait between injections, the more likely you are to get pregnant.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
