If you take cholestyramine or colestipol, take your pravastatin dose 1 hours before or 4 hours after you take the other medicine.
Some drugs can increase your risk of serious muscle problems if you take them together with pravastatin. Your doctor may need to change your treatment plan if you use any of the following drugs:
cyclosporine;
danazol;
gemfibrozil, fenofibric acid, fenofibrate; or
medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others).
This list is not complete. Other drugs may interact with pravastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Pravastatin drug interactions (more detail)
