Sometimes it is not safe to use certain medications at the same time. Some drugs can lower your blood levels of medroxyprogesterone and make it less effective in preventing pregnancy.
Tell your doctor about all your other medicines, especially:
St. John's wort;
sleep medicine;
seizure medicine;
medicine to treat an infection;
HIV or AIDS medication;
bosentan;
modafinil; or
mitotane.
This list is not complete and many other drugs may interact with medroxyprogesterone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Depo-Provera drug interactions (more detail)
