(77,'bactroban','Use Bactroban cream or ointment exactly as directed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nDo not take by mouth. Bactroban is for use only on the skin. If this medicine gets in your eyes, nose, or mouth, rinse with water.\nWash your hands before and after applying Bactroban.\nClean and dry the affected skin area. Use a cotton swab or gauze pad to apply a small amount of Bactroban cream or ointment as directed.\nDo not spread Bactroban over large areas of skin.\nBactroban is usually applied 3 times per day for 10 days. Use only a small amount of the cream or ointment.\nUse only a sterile gauze pad to cover the treated skin. Do not cover treated areas with a bandage, plastic wrap, or other covering that does not allow air to circulate.\nCall your doctor if your symptoms do not improve within 3 to 5 days, or if your skin condition gets worse.\nUse this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.\nStore at room temperature away from moisture and heat. Do not freeze. Keep the medicine tube tightly closed when not in use.\n Detailed Bactroban dosage information\nWhat happens if I miss a dose?\nApply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nAn overdose of Bactroban cream or ointment is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\n','It is not likely that other drugs you take orally or inject will have an effect on topically applied mupirocin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.\n','Get emergency medical help if you have signs of an allergic reaction to Bactroban: hives; dizziness, fast or pounding heartbeats; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\nsevere itching, rash, or other irritation of treated skin;\nunusual skin blistering or peeling; or\nany signs of a new skin infection.\nCommon Bactroban side effects may include:\nburning, stinging;\nitching; or\npain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bactroban side effects (more detail)\n','Bactroban (mupirocin) is an antibiotic that prevents bacteria from growing on your skin.\nBactroban topical (for use on the skin) is used to treat skin infections such as impetigo or a \"Staph\" infection of the skin.\nBactroban may also be used for purposes not listed in this medication guide.\n','Use Bactroban cream or ointment for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed. Avoid your eyes, nose, mouth, and lips when applying Bactroban. If medication gets in any of these areas, wash with water.\nWatch for signs of improvement in 3 to 5 days. If your condition gets worse or does not improve, see your doctor.\nA separate formulation, Bactroban nasal ointment, is available for nasal use.\nBefore taking this medicine\nYou should not use Bactroban cream or ointment if you are allergic to mupirocin.\nTo make sure Bactroban is safe for you, tell your doctor if you have ever had:\nkidney disease.\nDo not use Bactroban on a child without medical advice. The cream should not be used on a child younger than 3 months old. The ointment may be used on a child as young as 2 months old.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether mupirocin topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. If you apply this medicine to your breast or nipple, wash the areas thoroughly before nursing your baby.\n','Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.\nAvoid getting this medicine in your eyes, mouth, or nose. A separate product called Bactroban nasal is made for use in the nose. Bactroban topical is for use only on the skin.\nAvoid using other medications on the areas you treat with Bactroban unless your doctor tells you to.\n'),(78,'banzel','Usual Adult Dose for Lennox-Gastaut Syndrome:\nInitial dose: 400 to 800 mg orally per day in 2 equally divided doses\n-Titrate in 400 to 800 mg increments every other day until a maximum daily dose of 3200 mg/day is reached\nMaintenance dose: 1600 mg orally twice a day\nComments:\n-It is not known if doses lower than 3200 mg/day are effective.\n-For patients concomitantly receiving valproate, initial doses should be lower; see dose adjustments section.\nUse: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome.\nUsual Pediatric Dose for Lennox-Gastaut Syndrome:\n1 year of age or older:\nInitial dose: 10 mg/kg/day orally in 2 equally divided doses\n-Titrate in 10 mg/kg increments every other day to a target dose of 45 mg/kg/day\nMaintenance dose: 45 mg/kg orally per day in 2 equally divided doses\nMaximum dose: 3200 mg/day\nComments:\n-It is not known if doses lower than 45 mg/kg (not to exceed 3200 mg/day) are effective.\n-For patients concomitantly receiving valproate, initial doses should be lower; see dose adjustments section.\nUse: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older\n Detailed Banzel dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nGet your prescription refilled before you run out of medicine completely.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using Banzel with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nTell your doctor about all your other medicines, especially:\nvalproic acid (Depakene, Stavzor).\nThis list is not complete. Other drugs may interact with rufinamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Banzel drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Banzel: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSeek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, agitated, hostile, aggressive, restless, irritable, hyperactive, talkative, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\nloss of balance or coordination;\ntrouble walking; or\nworsening or increased seizures.\nCommon Banzel side effects may include:\nheadache;\ndizziness, drowsiness;\nnausea; or\nfeeling tired.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Banzel side effects (more detail)\n','Banzel (rufinamide) is a seizure medication, also called an anti-epileptic or anticonvulsant.\nBanzel is used together with other medicines to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems.\nBanzel is for use in adults and children who are at least 1 year old.\n','You should not use Banzel if you have a severe liver disease, or a genetic heart rhythm disorder called short QT syndrome.\nYou should not stop taking Banzel suddenly, unless your doctor tells you to stop the medicine because of a serious side effect.\nSome people have thoughts about suicide while taking seizure medication. Stay alert to changes in your mood or symptoms.\nBefore taking this medicine\nYou should not use Banzel if you are allergic to rufinamide, or if you have:\na genetic heart rhythm disorder called short QT syndrome; or\nsevere liver disease.\nTo make sure Banzel is safe for you, tell your doctor if you have ever had:\nheart disease;\nliver disease;\nkidney disease (or if you are on dialysis); or\ndepression, mental illness, or suicidal thoughts or actions.\nSome people have thoughts about suicide while taking Banzel. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nDo not start or stop taking seizure medication during pregnancy without your doctor\'s advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of rufinamide on the baby.\nBanzel can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using rufinamide, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nBanzel should not be given to a child younger than 1 year old.\nHow should I take Banzel?\nTake Banzel exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nTake Banzel with food.\nThe tablet may be swallowed whole, crushed, or cut in half.\nShake the oral suspension (liquid) well just before you measure a dose.\nMeasure the liquid using the dosing syringe and bottle adapter provided with this medicine. Insert the adapter into the bottle and snap it into place. Insert the syringe into the adapter and turn the bottle upside down. To measure your dose, pull the plunger to the correct number of milliliters marked on the side of the syringe. Rinse the syringe with water after each use.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nCall your doctor if your seizures get worse or you have them more often while taking Banzel.\nYou should not stop using Banzel suddenly, unless your doctor tells you to stop the medicine because of a serious side effect. Stopping suddenly may cause increased seizures. Follow your doctor\'s instructions very carefully.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\nStore the liquid medicine in an upright position. Do not try to remove the bottle adapter once it is in place. Throw away Banzel liquid 90 days after you first opened the bottle, even if there is medicine left inside.\nIn case of emergency, wear or carry medical identification to let others know you use rufinamide.\n','Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.\nDrinking alcohol can increase certain side effects of rufinamide.\n'),(79,'baqsimi','Baqsimi is a powder medicine that is inserted into the nose but does not need to be inhaled. You will be shown how to use this medicine for severe hypoglycemia. Call your doctor after each time you use nasal.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don\'t understand all instructions.\nHypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.\nBe sure you know how to give Baqsimi nasal powder before you need to use it. Follow your doctor\'s dosing instructions very carefully.\nIf you are a caregiver, get emergency medical help after giving Baqsimi nasal powder. If the patient does not improve within 15 minutes, you may need to give a second dose.\nDo not push the plunger or test the device prior to administration.\nAdminister Baqsimi according to the printed instructions on the shrink-wrapped tube label and the Instructions for Use.\nAdminister the dose by inserting the tip into one nostril and pressing the device plunger all the way in until the green line is no longer showing. The dose does not need to be inhaled.\nCall for emergency assistance immediately after administering the dose.\nWhen the patient responds to treatment, give oral carbohydrates to restore the liver glycogen and prevent recurrence of hypoglycemia.\nDo not attempt to reuse Baqsimi . Each Baqsimi device contains one dose of glucagon and cannot be reused.\nBlood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.\nTo keep from having severe hypoglycemia, follow your diet, medication, and exercise routines very closely.\nAfter using Baqsimi nasal powder, you should eat a fast-acting source of sugar (fruit juice, glucose gel, hard candy, raisins, or non-diet soda) and then eat a snack or small meal such as crackers with cheese or peanut butter.\nStore at room temperature away from moisture and heat. Keep the medicine in the original packaging until you are ready to use it. Replace the medicine if the expiration date on the label has passed.\n Detailed Baqsimi dosage information\nWhat happens if I miss a dose?\nSince Baqsimi is used as needed, it does not have a daily dosing schedule.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, vomiting, constipation, rapid pulse, or increased blood pressure (severe headache, blurred vision, pounding in your neck or ears).\n','Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of medicines used to treat diabetes. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all medicines you start or stop using.\n Baqsimi drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Baqsimi: hives; difficulty breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have symptoms of high blood pressure, such as severe headache, blurred vision, and pounding in your neck or ears.\nCommon Baqsimi side effects may include:\ndiscomfort in your nose, runny or stuffy nose;\nnosebleed;\nnausea, vomiting;\nred or watery eyes;\nitchy eyes, nose, or throat;\ncough; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Baqsimi side effects (more detail)\n','Baqsimi (glucagon) is a hormone that increases blood sugar levels. It also slows involuntary muscle movements of the stomach and intestines that aid in digestion.\nBaqsimi Nasal Powder is a prescription medicine used to treat severe hypoglycemia (low blood sugar) in adult and children at least 4 years old.\nBaqsimi may also be used for purposes not listed in this medication guide.\n','Baqsimi should be used to treat hypoglycemia only if the person cannot eat, passes out, or is having a seizure. Be sure you know how to give Baqsimi nasal powder before you need to use it. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.\nYou should not use this medicine if you have a tumor of the pancreas (insulinoma) or adrenal gland (pheochromocytoma).\nBefore taking this medicine\nYou should not use Baqsimi if you are allergic to glucagon, or if you have:\na tumor of the pancreas (insulinoma); or\na tumor of the adrenal gland (pheochromocytoma).\nBaqsimi should be used to treat hypoglycemia only if the person is unable to eat, or is unconscious or having a seizure.\nTell your doctor if:\nyou have any tumor of the pancreas;\nyou have not recently eaten on a regular basis; or\nyou have chronic low blood sugar.\nDo not give this medicine to a child without medical advice.\nGlucagon is not expected to harm an unborn baby, but quickly treating hypoglycemia would outweigh any risks posed by using Baqsimi.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nIn an emergency situation it may not be possible to tell your caregivers if you are pregnant or breastfeeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.\n','Do not take by mouth. Nasal medicine is for use only in the nose.\nAvoid drinking alcohol. It can lower your blood sugar.\n'),(80,'basaglar','Use Basaglar exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use Basaglar in larger or smaller amounts or for longer than recommended.\nRead all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.\nThe Toujeo brand of insulin glargine contains 3 times as much insulin per milliliter (mL) as the Basaglar brand. There are 300 units of insulin in 1 mL of Toujeo, and 100 units in 1 mL of Basaglar.\nIf there are any changes in the brand, strength, or type of insulin you use, your dosage needs may change.\nBasaglar is injected under the skin. You will be shown how to use injections at home. Do not give yourself Basaglar if you do not understand how to use the injection and properly dispose of used needles and pens.\nBasaglar must not be given with an insulin pump, or mixed with other insulins. Do not inject Basaglar into a vein or a muscle.\nDo not inject this medicine into skin that is damaged, tender, bruised, pitted, thickened, scaly, or has a scar or hard lump.\nBasaglar is usually injected once per day at the same time each day. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and pens.\nYour care provider will show you the best places on your body to inject Basaglar. Use a different place each time you give an injection. Do not inject into the same place two times in a row.\nUse only the injection pen that comes with Basaglar KwikPen. Attach a new needle before each use. Do not transfer the insulin from the pen into a syringe.\nNever share an injection pen with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.\nUse a disposable needle only once. Follow any state or local laws about throwing away used needles. Use a puncture-proof \"sharps\" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.\nYou may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).\nYour doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.\nAlso watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination.\nBlood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your insulin dose or schedule.\nBasaglar is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor\'s instructions very closely.\nKeep Basaglar in its original container protected from heat and light. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.\nStoring unopened (not in use) Basaglar:\nRefrigerate and use until expiration date; or\nStore at room temperature and use within 28 days.\nDo not store an injection pen with the needle attached.\nDo not use the medicine if it looks cloudy, has changed colors, or has any particles in it. Call your pharmacist for new medicine.\nWear a diabetes medical alert tag in case of emergency. Any medical care provider who treats you should know that you have diabetes.\n Detailed Basaglar dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss a dose of Basaglar. You should not use more than one dose in a 24-hour period unless your doctor tells you to.\nKeep insulin on hand at all times. Get your prescription refilled before you run out of medicine completely.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. Insulin overdose can cause life-threatening hypoglycemia. Symptoms include drowsiness, confusion, blurred vision, numbness or tingling in your mouth, trouble speaking, muscle weakness, clumsy or jerky movements, seizure (convulsions), or loss of consciousness.\n','Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of insulin. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.\n Basaglar drug interactions (more detail)\n','Get emergency medical help if you have signs of insulin allergy to Basaglar: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.\nCall your doctor at once if you have:\nfluid retention - weight gain, swelling in your hands or feet, feeling short of breath; or\nlow potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.\nCommon Basaglar side effects may include:\nlow blood sugar;\nitching, mild skin rash; or\nthickening or hollowing of the skin where you injected the medicine.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Basaglar side effects (more detail)\nBefore taking this medicine\nYou should not use Basaglar if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).\nBasaglar is not approved for use by anyone younger than 6 years old, and should not be used to treat type 2 diabetes in a child of any age.\nTo make sure Basaglar is safe for you, tell your doctor if you have:\nliver or kidney disease;\nlow levels of potassium in your blood (hypokalemia); or\ndiabetic ketoacidosis (call your doctor for treatment).\nTell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using Basaglar may increase your risk of serious heart problems.\nTell your doctor if you are pregnant or breastfeeding.\nFollow your doctor\'s instructions about using Basaglar if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.\n','Basaglar (insulin glargine) is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood.\nBasaglar is used to improve blood sugar control in adults and children with diabetes mellitus.\nBasaglar is for use in adults with type 1 or type 2 diabetes, and in children at least 6 years old with type 1 diabetes.\nSome brands of insulin glargine are for use only in adults. Carefully follow all instructions for the brand of insulin glargine you are using.\n','Never share a Basaglar KwikPen with another person, even if the needle has been changed.\nYou should not use Basaglar if you are having an episode of hypoglycemia (low blood sugar), or if you are in a state of diabetic ketoacidosis (call your doctor for treatment).\nBasaglar is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.\n','Avoid medication errors by always checking the medicine label before injecting your insulin.\nAvoid drinking alcohol. It can cause low blood sugar and may interfere with your diabetes treatment.\n'),(81,'bavencio','Usual Adult Dose for Merkel Cell Carcinoma:\n800 mg IV over 60 minutes every 2 weeks\nDuration of therapy: Until disease progression or unacceptable toxicity\nUsual Adult Dose for Urothelial Carcinoma:\n800 mg IV over 60 minutes every 2 weeks\nDuration of therapy: Until disease progression or unacceptable toxicity\nUses:\n-For maintenance treatment of patients with locally advanced or metastatic urothelial carcinoma (UC) that has not progressed with first-line platinum-containing chemotherapy\n-Previously treated urothelial carcinoma: For treatment of patients with locally advanced or metastatic urothelial carcinoma (UC) who: Have disease progression during or following platinum-containing chemotherapy OR have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy\nUsual Adult Dose for Renal Cell Carcinoma:\n800 mg IV over 60 minutes every 2 weeks in combination with axitinib 5 mg orally 2 times a day (12 hours apart) with or without food\nDuration of therapy: Until disease progression or unacceptable toxicity\nUse: In combination with axitinib for the first-line treatment of patients with advanced renal cell carcinoma (RCC)\nUsual Pediatric Dose for Merkel Cell Carcinoma:\n12 years and older:\n800 mg IV over 60 minutes every 2 weeks\nDuration of therapy: Until disease progression or unacceptable toxicity\nUse: For metastatic Merkel cell carcinoma (MCC) in pediatric patients 12 years and older\n Detailed Bavencio dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss an appointment for your injection.\nWhat happens if I overdose?\nSince this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.\n','Other drugs may interact with avelumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Bavencio drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Bavencio: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSome side effects may occur during the injection. Tell your caregiver right away if you feel light-headed, itchy, feverish, chilled, or have stomach or back pain, trouble breathing, or flushing (warmth, redness, or tingly feeling).\nAvelumab works by causing your immune system to attack tumor cells. Avelumab may cause your immune system to attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.\nCall your doctor at once if you have:\nsudden chest pain or discomfort;\nsevere stomach pain, diarrhea, bloody or tarry stools;\nblistering or peeling skin rash;\npounding heartbeats or fluttering in your chest;\nflu-like symptoms;\npain or burning when you urinate;\njoint pain, weakness;\nvision changes;\nliver problems - loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nheart problems - chest pain or pressure, pain spreading to your jaw or shoulder, sweating;\nkidney problems - little or no urination, red or pink urine, swelling in your feet or ankles; or\nsigns of a hormonal disorder - feeling light-headed or very tired, rapid heartbeats, mood or behavior changes, deepened voice, increased hunger or thirst, increased urination, constipation, vomiting, hair loss, sweating, feeling cold, weight gain, or weight loss.\nCommon Bavencio side effects may include:\nhoarse voice;\ncough, shortness of breath;\ntrouble speaking;\npain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;\nsores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;\nsevere headache, blurred vision, pounding in your neck or ears;\npainful urination;\nstomach pain, nausea, diarrhea, loss of appetite;\nfeeling tired;\nchills, fever;\nmuscle pain, back pain, bone pain;\nrash;\nswelling in your hands or feet;\nredness or swelling where the injection was given;\nliver problems; or\nsymptoms of underactive thyroid - tiredness, depressed mood, dry skin, thinning hair, decreased sweating, weight gain, puffiness in your face, feeling more sensitive to cold temperatures.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bavencio side effects (more detail)\n','Bavencio (avelumab) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.\nBavencio is used to treat a type of skin cancer called Merkel cell carcinoma in adults and children at least 12 years old, when the cancer has spread to other parts of the body (metastatic).\nBavencio is also used to treat a certain type of cancer of the bladder or urinary tract that has spread or cannot be removed with surgery. Bavencio is given for this condition after platinum cancer medicines did not work or have stopped working.\nBavencio is also used alone or in combination with another medicine called axitinib to treat advanced kidney cancer that has spread or cannot be removed with surgery.\n','Bavencio works by causing your immune system to attack tumor cells. Avelumab may cause your immune system to attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.\nCall your doctor at once if you have symptoms such as: fever, cough, flu symptoms, muscle pain or weakness, vision changes, chest pain, trouble breathing, severe stomach pain or diarrhea, skin rash, swelling in your ankles, increased or decreased urination, blood in your urine or stools, weight changes, hair loss, unusual bleeding, dark urine, or jaundice (yellowing of your skin or eyes).\nBefore taking this medicine\nTo make sure Bavencio is safe for you, tell your doctor if you have ever had:\na condition that affects your nervous system such as myasthenia gravis or Guillain-Barré syndrome;\nan immune system disorder such as ulcerative colitis or Crohn\'s disease;\nlung problems or a breathing disorder;\nliver or kidney disease;\nheart problems or high blood pressure;\nhigh cholesterol;\ndiabetes;\nan organ transplant; or\nif you have received or will receive a transplant of stem cells from a donor.\nYou should not use avelumab if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.\nYou should not breastfeed while using this medicine and for at least 1 month after your last dose.\nHow is Bavencio given?\nBavencio is given as an infusion into a vein, usually once every 2 weeks. A healthcare provider will give you this injection.\nBavencio must be given slowly and the IV infusion can take at least 60 minutes to complete.\nYou may be given other medication to prevent certain side effects that may occur during the infusion.\nYou may need frequent medical tests to check your heart or liver function, and to help your doctor determine how long to treat you with Bavencio.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(82,'belbuca','Use Belbuca exactly as prescribed by your doctor. Follow all directions on your prescription label. Buprenorphine can slow or stop your breathing. Never use Belbuca in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.\nBuprenorphine may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away Belbuca is against the law.\nRead all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.\nDrink a glass of water to moisten your mouth. Use dry hands when handling the buccal film. Place the film against the inside of your cheek and hold it in place for 5 seconds. Once in place, the film will dissolve completely in about 30 minutes. Do not chew the film or swallow it whole.\nDo not eat or drink anything until the Belbuca film has completely dissolved in your mouth.\nWhile using Belbuca, you may need frequent blood tests to check your liver function.\nIf you need surgery, tell the surgeon ahead of time that you are using Belbuca.\nDo not stop using Belbuca suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using buprenorphine.\nStore at room temperature away from moisture and heat. Keep the medicine in a place where a child cannot get to it. Keep track of your medicine. Buprenorphine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nDo not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, remove any unused films from the foil pack and flush the films down the toilet. Throw the empty foil pack into the trash.\n Detailed Belbuca dosage information\nWhat happens if I miss a dose?\nSince this medicine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. A buprenorphine overdose can be fatal, especially in a child or other person using the medicine without a prescription.\nOverdose symptoms may include extreme drowsiness or weakness, cold or clammy skin, severe muscle weakness, pinpoint pupils, weak pulse, very slow breathing, or coma.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nOpioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother narcotic medications - opioid pain medicine or prescription cough medicine;\na sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;\ndrugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or\ndrugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete. Other drugs may interact with buprenorphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Belbuca drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Belbuca: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nLike other narcotic medicines, buprenorphine can slow your breathing. Death may occur if breathing becomes too weak.\nA person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nnoisy breathing, sighing, shallow breathing, breathing that stops during sleep;\nslow heartbeat or weak pulse;\na light-headed feeling, like you might pass out;\nchest pain, fast heart rate, trouble breathing;\nsevere constipation;\nopioid withdrawal symptoms - shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain;\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or\nliver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nSeek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.\nSerious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.\nLong-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.\nCommon Belbuca side effects may include:\nconstipation, nausea, vomiting;\nheadache, dizziness, drowsiness;\nincreased sweating;\nsleep problems (insomnia); or\npain anywhere in your body.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Belbuca side effects (more detail)\n','Belbuca buccal films contain buprenorphine, an opioid medication. An opioid is sometimes called a narcotic.\nBelbuca buccal films are for around-the-clock treatment of moderate to severe chronic pain that is not controlled by other medicines.\nBelbuca is not for use on an as-needed basis for occasional pain.\nThe Belbuca buccal film is placed between the gum and cheek where it adheres to the moist buccal mucosa to deliver the medicine as the film dissolves.\n','Belbuca can slow or stop your breathing, and may be habit-forming. MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.\nUsing Belbuca during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use Belbuca with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore using this medicine\nYou should not use Belbuca if you are allergic to buprenorphine, or if you have:\nsevere asthma or trouble breathing; or\na blockage in your digestive tract, including a bowel obstruction called paralytic ileus.\nTo make sure Belbuca is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea;\nliver disease (especially hepatitis B or C);\nkidney disease;\nenlarged prostate, urination problems;\nproblems with your gallbladder, pancreas, or thyroid;\na head injury, brain tumor, or seizures;\ndrug addiction, methadone use, alcoholism, mental illness;\nmouth sores caused by cancer;\nan electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or\nlong QT syndrome, or if you take heart rhythm medication.\nIf you use Belbuca while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.\nBuprenorphine can pass into breast milk and may harm a nursing baby. You should not breastfeed while you are using Belbuca.\nBelbuca is not approved for use by anyone younger than 18 years old.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid applying the buccal film to an area where you have a mouth sore.\nBuprenorphine may impair your thinking or reactions. Avoid driving or operating machinery until you know how Belbuca will affect you. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries.\n'),(83,'belsomra','Usual Adult Dose for Insomnia:\n10 mg orally once a day at bedtime\nMaximum dose: 20 mg once a day\nComments:\n-Take within 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening.\n-If 10 mg is well-tolerated but not effective, the dose can be increased.\n-Time to effect may be delayed if taken with or soon after a meal.\nUse: Insomnia characterized by difficulties with sleep onset and/or sleep maintenance.\n Detailed Belsomra dosage information\nWhat happens if I miss a dose?\nSince Belsomra is taken only at bedtime if needed, you are not likely to miss a dose. Never take this medicine if you do not have 7 hours to sleep before being active again.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Using Belsomra with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nSometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may interact with suvorexant, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Belsomra drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Belsomra: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nSome people using this medicine have engaged in activity while not fully awake and later had no memory of it. This may include walking, driving, eating, having sex, or making phone calls. If this happens to you, call your doctor right away.\nCall your doctor at once if you have:\ntrouble moving or talking when you first wake up;\na weak feeling in your legs;\nunusual thoughts or behavior;\nanxiety, agitation, depression;\nmemory problems;\nconfusion, hallucinations; or\nthoughts about hurting yourself.\nYou may be more likely to have side effects if you are overweight.\nCommon Belsomra side effects include:\nstrange dreams; or\ndrowsiness during the day after taking this medicine.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Belsomra side effects (more detail)\n','Belsomra (suvorexant) is a sleep medicine that helps regulate your sleep and wake cycle.\nBelsomra is used to treat insomnia (trouble falling asleep or staying asleep).\nBelsomra may also be used for purposes not listed in this medication guide.\n','Do not take more Belsomra than your doctor has prescribed.\nYou should not use Belsomra if you have narcolepsy.\nTake Belsomra 30 minutes before bedtime. Never take this medicine if you do not have 7 hours to sleep before being active again.\nSome people using this medicine have engaged in activity while not fully awake and later had no memory of it. If this happens to you, call your doctor right away.\nBefore taking this medicine\nYou should not use Belsomra if you are allergic to suvorexant, or if you have narcolepsy.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\ndepression, mental illness, or thoughts about suicide;\ndrug or alcohol abuse or addiction;\nbreathing problems, sleep apnea (breathing stops during sleep);\nliver disease;\nsudden muscle weakness;\nexcessive sleepiness during normal waking hours; or\nif you have ever fallen asleep at unexpected times.\nTell your doctor if you are pregnant or breastfeeding.\nBelsomra is not approved for use by anyone younger than 18 years old.\nHow should I take Belsomra?\nTake Belsomra exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.\nBelsomra may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.\nTake Belsomra only once per night, 30 minutes before bedtime.\nYou may take Belsomra with or without food. Avoid taking the medicine shortly after eating a meal, or the medicine may take longer to work.\nBelsomra will make you fall asleep. Never take this medicine if you do not have 7 hours to sleep before being active again.\nYou may have trouble speaking or moving while you are falling asleep. It may take longer for you to wake up, speak, or move around when you wake up. You may feel like you are still dreaming for several minutes after waking.\nCall your doctor if your insomnia symptoms do not improve, or if they get worse after using Belsomra for 7 to 10 nights in a row.\nStore at room temperature away from moisture, heat, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.\n','For at least 8 hours after taking Belsomra, do not drive or do anything that requires you to be alert. Your reactions may be impaired.\nAvoid drinking alcohol. Do not take Belsomra if you have consumed alcohol within a few hours before getting ready for sleep.\n'),(84,'benadryl','Use Benadryl exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.\nDo not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.\nYou should not use Benadryl to make a child sleepy.\nMeasure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nFor motion sickness, take Benadryl 30 minutes before you will be in a situation that causes you motion sickness (such as a long car ride, airplane or boat travel, amusement park rides, etc). Continue taking Benadryl with meals and at bedtime for the rest of the time you will be in a motion-sickness situation.\nAs a sleep aid, take Benadryl within 30 minutes before bedtime.\nCall your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.\nThis medication can affect the results of allergy skin tests. Tell any doctor who treats you that you are using Benadryl.\nStore at room temperature away from moisture and heat.\n Detailed Benadryl dosage information\nWhat happens if I miss a dose?\nSince Benadryl is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.\nTaking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking Benadryl with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.\n Benadryl drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Benadryl: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using Benadryl and call your doctor at once if you have:\npounding heartbeats or fluttering in your chest;\npainful or difficult urination;\nlittle or no urinating;\nconfusion, feeling like you might pass out; or\ntightness in your neck or jaw, uncontrollable movements of your tongue.\nCommon Benadryl side effects may include:\ndizziness, drowsiness, loss of coordination;\ndry mouth, nose, or throat;\nconstipation, upset stomach;\ndry eyes, blurred vision; or\nday-time drowsiness or \"hangover\" feeling after night-time use.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Benadryl side effects (more detail)\n','Benadryl (diphenhydramine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.\nBenadryl is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.\nBenadryl is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson\'s disease.\n','You should not use Benadryl to make a child sleepy.\nWhen taking Benadryl, use caution driving, operating machinery, or performing other hazardous activities. Diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.\nUse alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking Benadryl.\nDo not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.\nBefore taking this medicine\nYou should not use Benadryl if you are allergic to diphenhydramine.\nAsk a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:\nblockage in your digestive tract (stomach or intestines);\nbladder obstruction or other urination problems;\na colostomy or ileostomy;\nliver or kidney disease;\nasthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;\ncough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;\nheart disease, low blood pressure;\nglaucoma;\na thyroid disorder; or\nif you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).\nIt is not known whether Benadryl will harm an unborn baby. Ask a doctor before using this medicine if you are pregnant.\nDiphenhydramine can pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Ask a doctor before using this medicine if you are breast-feeding.\nOlder adults may be more likely to have side effects from this medicine.\n','Benadryl may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.\nDrinking alcohol can increase certain side effects of diphenhydramine.\nAsk a doctor or pharmacist before using any other cold, cough, allergy, or sleep medicine. Antihistamines are contained in many combination medicines. Taking certain products together can cause you to get too much of this type of medicine. Check the label to see if a medicine contains an antihistamine.\n'),(85,'benazepril','Usual Adult Dose for Hypertension:\nInitial dose: With a diuretic: 5 mg orally once a day; without a diuretic: 10 mg orally once a dayMaintenance dose: 20 to 40 mg/day orally as a single dose or in two equally divided dosesMaximum dose: 80 mg/dayComments:-The divided dose regimen was more effective in controlling pre-dosing blood pressure.-If discontinuing a diuretic prior to initiating this drug to reduce the likelihood of hypotension, conclude diuretic therapy 2 to 3 days prior to starting this drug.\nUsual Pediatric Dose for Hypertension:\n6 YEARS OR OLDER:Initial dose: 0.2 mg/kg orally once a day as monotherapyMaximum dose: 0.6 mg/kg; 40 mg/dayComments:-Doses between 0.1 and 0.6 mg/kg once a day have been studied; doses greater than 0.1 mg/kg were shown to reduce blood pressure; doses above 0.6 mg/kg or 40 mg/day have not been studied in pediatric patients.-Prepare a suspension for pediatric patients who cannot swallow tablets or for whom the calculated dosage does not correspond to available tablet strengths.\n Detailed Benazepril dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\n','Tell your doctor about all your current medicines. Many drugs can affect benazepril, especially:\na diuretic (\"water pill\"), or any other blood pressure medications;\nlithium;\ngold injections to treat arthritis;\ninsulin or oral diabetes medicine; or\nNSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.\nThis list is not complete and many other drugs may affect benazepril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Benazepril drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nlittle or no urinating;\nhigh potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or\nliver problems--stomach pain (upper right side), loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).\nCommon side effects may include:\nheadache; or\ncough.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Benazepril side effects (more detail)\n','Benazepril is an ACE inhibitor that is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.\nBenazepril may also be used for purposes not listed in this medication guide.\n','Do not use if you are pregnant. If you become pregnant, stop taking  benazepril and tell your doctor right away.\nYou should not use this medicine if you have ever had angioedema. Do not take benazepril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).\nIf you have diabetes, do not use benazepril together with any medication that contains aliskiren (a blood pressure medicine).\nBefore taking this medicine\nYou should not use benazepril if you are allergic to it, or if:\nyou have hereditary angioedema;\nyou recently took a heart medicine called sacubitril; or\nyou have ever had a severe allergic reaction to any ACE inhibitor (captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril).\nDo not take benazepril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).\nIf you have diabetes, do not use benazepril together with any medication that contains aliskiren (a blood pressure medicine).\nYou may also need to avoid taking benazepril with aliskiren if you have kidney disease.\nTell your doctor if you have ever had:\nkidney disease (or if you are on dialysis);\nliver disease;\nheart disease; or\nan organ transplant.\nDo not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.\nYou should not breast-feed while you are using benazepril.\nBenazepril is not approved for use by anyone younger than 6 years old.\nHow should I take benazepril?\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nYou may take benazepril with or without food.\nDrink plenty of water each day while you are taking  benazepril.\nYour blood pressure will need to be checked often. Your kidney function may also need to be checked.\nCall your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking benazepril.\nIf you need surgery, tell the surgeon ahead of time that you are using benazepril.\nKeep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nStore at room temperature away from moisture and heat.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nAvoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Benazepril can decrease sweating and you may be more prone to heat stroke.\nDrinking alcohol can further lower your blood pressure and may increase certain side effects of benazepril.\nDo not use potassium supplements or salt substitutes, unless your doctor has told you to.\n'),(86,'bendeka','Bendeka is given as an infusion into a vein. A healthcare provider will give you this injection.\nBendeka is usually given for 2 days in a row every 21 to 28 days. Your doctor will determine how long to treat you with this medicine.\nYou may be given other medications to help prevent certain side effects of bendamustine.\nTell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.\nBendeka affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.\nIf you\'ve ever had hepatitis B, using Bendeka can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.\n Detailed Bendeka dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss an appointment for your  Bendeka.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nTell your doctor about all your other medicines, especially:\nallopurinol.\nThis list is not complete. Other drugs may affect Bendeka, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Bendeka drug interactions (more detail)\nDoes Bendeka interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).\nSeek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.\nCall your doctor at once if you have:\nfever, chills, or itching during or shortly after the injection;\npain, swelling, redness, skin changes, or signs of infection where the medicine was injected;\nsevere ongoing nausea, vomiting, or diarrhea;\nliver problems--right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well;\nlow blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or\nsigns of tumor cell breakdown--confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.\nYour cancer treatments may be delayed if you have certain side effects.\nCommon side effects may include:\nfever, cough, mouth sores, trouble breathing;\nlow blood cell counts;\nnausea, vomiting, diarrhea, constipation;\nheadache, tiredness;\nrash; or\nloss of appetite, weight loss.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bendeka side effects (more detail)\n','Bendeka is used to treat chronic lymphocytic leukemia. This medicine is also used to treat indolent B-cell non-Hodgkin lymphoma after other medicines have been tried without successful treatment of this condition.\nBendeka may also be used for purposes not listed in this medication guide.\n','Tell your caregivers right away if you have any type of skin rash after being treated with Bendeka.\nBefore taking this medicine\nYou should not be treated with  Bendeka if you are allergic to Bendeka, polyethylene glycol, propylene glycol, or mannitol (Osmitrol).\nTell your doctor if you have ever had:\na weak immune system;\nfever or other signs of infection;\ntuberculosis;\nherpes zoster (also called shingles)\na metabolic disorder or electrolyte imbalance;\nliver disease;\nkidney disease; or\nif you smoke.\nUsing Bendeka may increase your risk of developing certain types of cancer. Ask your doctor about this risk.\nBendeka can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.\nIf you are a woman, do not use Bendeka if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.\nIf you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.\nTell your doctor right away if a pregnancy occurs while either the mother or the father is using Bendeka.\nThis medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because Bendeka can harm an unborn baby.\nDo not breastfeed while using this medicine, and for at least 1 week after your last dose.\n','Avoid driving or hazardous activity until you know how  Bendeka will affect you. Your reactions could be impaired.\n'),(87,'benicar','Usual Adult Dose for Hypertension:\n20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed.\nMaximum dose: 40 mg orally once a day\nComments:\n-For patients with possible intravascular volume depletion (e.g., patients treated with diuretics, especially those with impaired renal function), initiate this drug under close supervision and give consideration to a lower starting dose.\n-Twice daily dosing offers no additional benefit over the same total dose give once daily.\nUsual Pediatric Dose for Hypertension:\n6 to 16 years:\n-20 to less than 35 kg: 10 mg orally once a day; may increase dose to 20 mg in two weeks if further blood pressure reduction is needed\n-35 kg or more: 20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed\nComments:\n-For children who cannot swallow tablets, the same dose can be given using an extemporaneously compounded oral suspension.\n Detailed Benicar dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include fast heartbeats or fainting.\n','If you take colesevelam, take your Benicar dose 4 hours before you take colesevelam.\nTell your doctor about all your other medicines, especially:\nlithium;\na diuretic (water pill) or other medicines that lower blood pressure; or\nNSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.\nThis list is not complete. Other drugs may interact with olmesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Benicar drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Benicar: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nlittle or no urination;\nsevere diarrhea and weight loss; or\nhigh potassium level - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.\nCommon Benicar side effects may include:\ndizziness.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Benicar side effects (more detail)\n','Benicar (olmesartan) is an angiotensin II receptor blocker (sometimes called an ARB). Olmesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.\nBenicar is used to treat high blood pressure (hypertension) in adults and children at least 6 years old.\nBenicar is sometimes given together with other blood pressure medications.\n','Do not use if you are pregnant. Stop using Benicar and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.\nIf you have diabetes, do not take Benicar with any medication that contains aliskiren (a blood pressure medicine - brand names include Amturnide, Tekturna, and Tekamlo).\nBefore taking this medicine\nYou should not take Benicar if you are allergic to olmesartan.\nIf you have diabetes, do not use Benicar together with any medication that contains aliskiren (a blood pressure medicine).\nYou may also need to avoid taking Benicar with aliskiren if you have kidney disease.\nTo make sure Benicar is safe for you, tell your doctor if you have:\na heart condition other than one being treated with Benicar;\nkidney disease; or\nif you are on a low salt diet.\nDo not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.\nIf you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby.\nYou should not breastfeed while using this medicine.\nHow should I take Benicar?\nTake Benicar exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nYou may take Benicar with or without food.\nFor a child who cannot swallow a tablet whole, a pharmacist can mix the medicine into a liquid.\nShake the liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nOlmesartan doses are based on weight in children and/or teenagers. Your child\'s dose needs may change if the child gains or loses weight.\nCall your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Benicar.\nIt may take up to 2 weeks before your blood pressure is under control. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms.\nYou may need to use blood pressure medicine for the rest of your life. Treatment may also include diet, exercise, lowering cholesterol, not smoking, and controlling diabetes.\nYour blood pressure will need to be checked often. Your kidney function may also need to be checked.\nStore tablets at room temperature away from moisture and heat.\nStore the liquid in a refrigerator. Throw away any liquid leftover after 4 weeks.\n','Do not use potassium supplements or salt substitutes, unless your doctor has told you to.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy.\n'),(88,'bentyl','Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.\nBentyl is usually taken 4 times each day. Your doctor may occasionally change your dose to make sure you get the best results.\nTake this medicine with a full glass of water.\nMeasure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.\nTalk with your doctor if your symptoms do not improve after 2 weeks of treatment.\nStore at room temperature away from moisture and heat.\n Detailed Bentyl dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, vomiting, dilated pupils, weakness or loss of movement in any part of your body, trouble swallowing, fainting, or seizure (convulsions).\n','Before using Bentyl, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by this medicine.\nTell your doctor about all other medicines you use, especially:\namantadine (Symmetrel);\ndigoxin (Lanoxin, Lanoxicaps);\nmetoclopramide (Reglan);\natropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);\nbronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);\nbladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);\na heart rhythm medication such as quinidine (Quin-G), procainamide (Procan, Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others;\nirritable bowel medications such as hyoscyamine (Hyomax) or propantheline (Pro Banthine);\nan MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);\nnitrate medication, such as nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), or isosorbide mononitrate (Imdur, ISMO, Monoket);\nphenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), or trifluoperazine (Stelazine);\nsteroid medication such as prednisone and others; or\nulcer medication such as glycopyrrolate (Robinul) or mepenzolate (Cantil).\nThis list is not complete and other drugs may interact with Bentyl. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.\n Bentyl drug interactions (more detail)\n','Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using Bentyl and call your doctor at once if you have a serious side effect such as:\nsevere constipation, bloating, or stomach pain;\nworsening of diarrhea or other irritable bowel symptoms;\nfeeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin\nconfusion, hallucinations, unusual thoughts or behavior; or\npounding heartbeats or fluttering in your chest.\nLess serious side effects may include:\ndrowsiness, dizziness, weakness, nervousness;\nblurred vision;\ndry mouth, stuffy nose; or\nmild constipation.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bentyl side effects (more detail)\n','Bentyl relieves spasms of the muscles in the stomach and intestines.\nBentyl is used to treat functional bowel or irritable bowel syndrome.\nBentyl may also be used for purposes not listed in this medication guide.\n','This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDrinking alcohol can increase certain side effects of dicyclomine.\nAvoid becoming overheated or dehydrated during exercise and in hot weather. Bentyl can decrease your sweating, which can lead to heat stroke in a hot environment.\nStop using Bentyl and call your doctor right away if you have serious side effects such as confusion, hallucinations, unusual thoughts or behavior, fast or uneven heart rate, or if you urinate less than usual or not at all.\nThere are many other medicines that can interact with Bentyl. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.\nBefore taking this medicine\nYou should not take this medication if you are allergic to Bentyl, or if you have:\nproblems with urination;\na bowel obstruction or severe constipation;\nsevere ulcerative colitis or toxic megacolon;\ngastroesophageal reflux disease (GERD);\na serious heart condition or active bleeding;\nglaucoma;\nmyasthenia gravis; or\nif you are breast-feeding a baby.\nTo make sure you can safely take Bentyl, tell your doctor if you have any of these other conditions:\nulcerative colitis;\nan ileostomy or colostomy;\na nerve problem (such as numbness or tingling);\nliver or kidney disease;\nheart disease, congestive heart failure, high blood pressure, or a heart rhythm disorder;\nhiatal hernia; or\nan enlarged prostate.\nFDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.\nDicyclomine can pass into breast milk and can cause breathing problems or other life-threatening side effects in infants younger than 6 months of age. Do not breast feed a baby while taking this medication.\nOlder adults may be more likely to have side effects from  Bentyl.\nBentyl should not be given to a child younger than 6 months old.\n','This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.\nAvoid becoming overheated or dehydrated during exercise and in hot weather. Bentyl can cause decreased sweating, which can lead to heat stroke in a hot environment.\nDrinking alcohol can increase certain side effects of dicyclomine.\nAvoid using antacids without your doctor\'s advice. Use only the type of antacid your doctor recommends. Some antacids can make it harder for your body to absorb Bentyl.\n'),(89,'benzonatate','Usual Adult Dose for Cough:\n100 mg to 200 mg orally three times a day as needed for cough\nComments: This drug should be swallowed whole.\nUse: Symptomatic relief of cough\nUsual Pediatric Dose for Cough:\nChildren older than 10 years:\n100 mg to 200 mg orally three times a day as needed for cough\nComments: This drug should be swallowed whole.\nUse: Symptomatic relief of cough\n Detailed Benzonatate dosage information\n','Using benzonatate with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nOther drugs may interact with benzonatate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Benzonatate drug interactions (more detail)\n','Stop taking benzonatate and get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere drowsiness or dizziness;\nconfusion, hallucinations.\nongoing numbness or tingling in your mouth, throat, or face;\nnumbness in your chest;\na choking feeling;\nchills; or\nburning in your eyes.\nSome of these side effects may result from chewing or sucking on a benzonatate capsule.\nCommon benzonatate side effects may include:\nheadache, dizziness;\nnausea, upset stomach;\nconstipation;\nitching, rash; or\nstuffy nose.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Benzonatate side effects (more detail)\n','Benzonatate is a non-narcotic cough medicine.\nBenzonatate works by numbing the throat and lungs, making the cough reflex less active.\nBenzonatate is used to relieve coughing.\n','You should not use this medication if you are allergic to benzonatate or topical numbing medicines such as tetracaine or procaine (found in some insect bite and sunburn creams).\nNever suck or chew on a benzonatate capsule. Swallow the pill whole. Sucking or chewing the capsule may cause your mouth and throat to feel numb or cause other serious side effects.\nSerious side effects of benzonatate include choking feeling, chest pain or numbness, feeling like you might pass out, confusion, or hallucinations. Some of these side effects may result from chewing or sucking on a capsule.\nDo not give this medication to a child younger than 10 years old without medical advice. An overdose of benzonatate can be fatal to a child.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to benzonatate or topical numbing medicines such as tetracaine or procaine (found in some insect bite and sunburn creams).\nTell your doctor if you are pregnant or breastfeeding.\nBenzonatate is not approved for use by anyone younger than 10 years old. An overdose can be fatal, especially to a young child who has accidentally swallowed the medicine.\nHow should I take benzonatate?\nTake benzonatate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nAlways ask a doctor before giving a cough medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.\nTake each dose with a full glass of water.\nNever suck or chew on a benzonatate capsule. Swallow the pill whole. Sucking or chewing the capsule may cause serious side effects.\nStore at room temperature away from moisture, heat, and light.\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose at the regular time. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of benzonatate can be fatal, especially to a child. Accidental death has occurred in children under 10 years old.\nOverdose symptoms may include tremors, feeling restless, seizure (convulsions), slow heart rate, weak pulse, fainting, and slow breathing (breathing may stop).\n','Avoid eating or drinking anything while you feel numbness or tingling in your mouth or throat.\n'),(90,'benztropine','Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nBenztropine oral is taken by mouth.\nBenztropine is usually taken at bedtime.\nBenztropine injection is given in a muscle or vein if you are unable to take the medicine by mouth.\nDrink plenty of water to prevent dry mouth while taking benztropine.\nDry mouth may lead to gum disease or cavities. Brush and floss your teeth regularly and visit your dentist for routine dental care.\nCall your doctor if your symptoms do not improve, or if they get worse.\nYour symptoms may get worse if you stop using benztropine suddenly. Ask your doctor before stopping any of your anti-Parkinson medications.\nStore at room temperature away from moisture, heat, and light.\n Detailed Benztropine dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose may cause drowsiness, confusion, nervousness, hallucinations, fast heart rate, vomiting, numbness in your fingers, hot or dry skin, or fainting.\n','Tell your doctor about all your other medicines, especially:\nother medicine to treat Parkinson\'s disease;\nmedicine to treat depression, anxiety, mood disorders, or mental illness;\ncold or allergy medicine (Benadryl and others);\nmedicine to treat stomach problems, motion sickness, or irritable bowel syndrome;\nmedicine to treat overactive bladder; or\nbronchodilator asthma medication.\nThis list is not complete. Other drugs may affect benztropine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Benztropine drug interactions (more detail)\nDoes Benztropine interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\ndry mouth that causes trouble talking or swallowing;\nlittle or no urination;\nuncontrolled muscle movements;\nvomiting, severe constipation;\nfast heartbeats;\nmuscle weakness;\nblurred vision, tunnel vision, eye pain, or seeing halos around lights;\nconfusion, hallucinations; or\nsevere skin rash.\nCommon side effects may include:\ndry mouth;\nblurred vision;\nconstipation; or\nnausea.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Benztropine side effects (more detail)\n','Benztropine is used with other medicines to treat symptoms of Parkinson\'s disease, such as stiffness or tremors.\nBenztropine is also used to treat Parkinson-like symptoms caused by using certain medicines.\nBenztropine may also be used for purposes not listed in this medication guide.\n','Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.\nBefore taking this medicine\nYou should not use benztropine if you are allergic to it.\nNot approved for use by anyone younger than 3 years old.\nTell your doctor if you have ever had:\nan enlarged prostate;\nurination problems;\nglaucoma; or\nmuscle problems.\nOlder adults may be more sensitive to the effects of  benztropine.\nIt is not known if benztropine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nTell your doctor if you are breastfeeding.\n','Avoid driving or hazardous activity until you know how  benztropine will affect you. Your reactions could be impaired.\nAvoid becoming overheated or dehydrated during exercise and in hot weather. Benztropine can decrease sweating and you may be more prone to heat stroke.\n'),(91,'betamethasone-topical','Usual Adult Dose for Dermatitis:\nCream, gel, ointment: Apply a thin film topically to the affected area 1 or 2 times a day\nFoam, lotion: Apply topically twice a day (morning and night)\nComments:\n-Treatment should be discontinued when control is achieved; if no improvement is seen within 2 weeks, reassessment may be necessary.\n-Occlusive dressings should not be used unless directed by a healthcare provider.\nUse: Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses\nUsual Adult Dose for Plaque Psoriasis:\nSpray:\n-Apply topically to affected skin areas twice a day; rub in gently\nDuration of Treatment: Up to 4 weeks\nComments:\n-Discontinue therapy when control is achieved; treatment beyond 4 weeks is not recommended.\nUse: For the treatment of mild to moderate plaque psoriasis.\nUsual Pediatric Dose for Dermatitis:\n12 years or older:\nCream, gel, ointment: Apply a thin film topically to the affected area 1 or 2 times a day\nFoam, lotion: Apply topically twice a day (morning and night)\nComments:\n-Treatment should be discontinued when control is achieved; if no improvement is seen within 2 weeks, reassessment may be necessary.\n-Occlusive dressings should not be used unless directed by a healthcare provider.\n-Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of children.\nUse: Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses\n Detailed Betamethasone topical dosage information\n','Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.\n Betamethasone topical drug interactions (more detail)\nWhat happens if I miss a dose?\nApply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\nLong term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.\n','Get emergency medical help if you have signs of an allergic reaction to betamethasone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nStop using betamethasone and call your doctor at once if you have:\nsevere skin irritation where the medicine was applied; or\nsigns of skin infection (swelling, redness, warmth, oozing).\nYour skin can absorb topical steroid medicine, which may cause steroid side effects throughout the body. Stop using betamethasone and call your doctor if you have:\nblurred vision, tunnel vision, eye pain, or seeing halos around lights;\nslow wound healing, thinning skin, increased body hair;\nincreased thirst or urination, dry mouth, fruity breath odor;\nweight gain, puffiness in your face; or\nmuscle weakness, tired feeling, depression, anxiety, feeling irritable.\nSteroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.\nCommon betamethasone side effects may include:\nitching, redness, burning, stinging, or blistering of treated skin;\nskin bruising or shiny appearance; or\nfolliculitis (redness or crusting around your hair follicles).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Betamethasone topical side effects (more detail)\n','Betamethasone is a highly potent steroid that prevents the release of substances in the body that cause inflammation.\nBetamethasone topical (for the skin) is used to treat the inflammation and itching caused by a number of skin conditions such as eczema or psoriasis.\nBetamethasone topical is available in a cream, gel, ointment, lotion, foam or spray.\n','Do not use betamethasone longer than you have been told to by your doctor. Use care when using on a large part of the skin. Talk with your doctor.\nDo not use to treat diaper rash or redness. Avoid applying betamethasone cream, gel, ointment, lotion, foam, or spray to the diaper area.\nDifferent brands of betamethasone may be for use in different ages of children. Talk with the doctor before using betamethasone cream, gel, ointment, lotion, foam, or spray on a child.\nIf you are breast-feeding, do not apply betamethasone cream, gel, ointment, lotion, foam, or spray to the nipple or the area around it.\nBetamethasone may raise the chance of cataracts or glaucoma. Talk to your doctor.\nBefore taking this medicine\nYou should not use betamethasone if you are allergic to it.\nTo make sure betamethasone is safe for you, tell your doctor if you have ever had:\nskin irritation after using steroid medicine;\nthinning of the skin where you will apply betamethasone;\ncataracts or glaucoma;\ndiabetes;\nliver disease;\nadrenal gland problems; or\nany type of skin infection.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.\nIt may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks. If you apply betamethasone to your chest, avoid areas that may come into contact with the baby\'s mouth.\nDo not use betamethasone on a child without a doctor\'s advice. Children can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.\nDiprolene is not approved for use by anyone younger than 13 years old. Sernivo and Luxiq are not approved for anyone younger than 18 years old.\nHow should I use betamethasone ?\nUse betamethasone cream, gel, ointment, lotion, foam, or spray exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nDo not take by mouth. Topical medicine is for use only on the skin. Do not use on open wounds or on sunburned, windburned, dry, or irritated skin. Rinse with water if this medicine gets in your eyes or mouth.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nWash your hands before and after using this medicine, unless you are using the medicine to treat the skin on your hands.\nApply a small amount to the affected area and rub it gently into the skin. Do not apply betamethasone cream, gel, ointment, lotion, foam, or spray over a large area of skin.\nDo not cover the treated skin area unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.\nUse betamethasone regularly to get the most benefit. Stop using the medicine once your symptoms clear up.\nCall your doctor if your skin condition does not improve after 2 weeks, or if it gets worse.\nDo not use Diprolene for longer than 2 weeks in a row. Do not use Sernivo or Luxiq for longer than 4 weeks.\nStore at room temperature away from moisture and heat.\nThe foam is flammable. Do not use near high heat or open flame. Do not smoke until the foam has completely dried on your skin.\n','Do not get betamethasone topical in your eyes. If contact does occur, rinse with water.\nAvoid applying betamethasone to the skin of your face, underarms, or groin area without your doctor\'s instruction.\nDo not use betamethasone to treat any condition that has not been checked by your doctor.\n'),(92,'biaxin','This section provides information on the proper use of a number of products that contain clarithromycin.  It may not be specific to Biaxin. Please read with care.\nTake this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.\nYou may take this medicine with meals or milk or on an empty stomach. However, clarithromycin extended release tablets should be taken with food.\nIf you are using the extended-release tablets:\nSwallow the tablet whole. Do not break, crush, or chew it.\nWhile taking the extended-release form of this medicine, a part of the tablet may pass into your stools. This is normal and is nothing to worry about.\nMeasure the oral liquid with a marked measuring spoon, syringe, or cup. The average household teaspoon may not hold the right amount of liquid. Shake the bottle well before each use.\nIf you are taking clarithromycin and zidovudine, these medicines should be taken at least 2 hours apart.\nKeep using this medicine for the full time of treatment, even if you or your child begin to feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.\nDosing\nThe dose of this medicine will be different for different patients. Follow your doctor\'s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.\nThe amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.\nFor oral dosage form (extended-release tablets):\nFor bacterial infections:\nAdults—1000 milligrams (mg) once a day for 7 to 14 days.\nChildren—Use and dose must be determined by your doctor.\nFor community-acquired pneumonia:\nAdults—1000 milligrams (mg) once a day for 7 days.\nChildren—Use and dose must be determined by your doctor.\nFor oral dosage forms (suspension and tablets):\nFor bacterial infections:\nAdults—250 to 500 milligrams (mg) every 12 hours for 7 to 14 days.\nChildren 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 12 hours for 10 days.\nInfants younger than 6 months of age—Use and dose must be determined by your doctor.\nFor community-acquired pneumonia:\nAdults—250 milligrams (mg) every 12 hours for 7 to 14 days.\nChildren 6 months of age and older—Dose is based on body weight and must be determined by your doctor.\nInfants younger than 6 months of age—Use and dose must be determined by your doctor.\nFor prevention or treatment of Mycobacterium avium complex (MAC) infection:\nAdults—500 milligrams (mg) 2 times a day.\nChildren 20 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight, up to 500 mg, 2 times a day.\nChildren younger than 20 months of age—Use and dose must be determined by your doctor.\nFor treatment of ulcers associated with H. pylori:\nAdults—500 milligrams (mg) every 8 hours for 14 days in combination with omeprazole, 500 mg every 12 hours in combination with amoxicillin and lansoprazole for 10 or 14 days, or 500 mg every 12 hours in combination with amoxicillin and omeprazole for 10 days.\nChildren—Use and dose must be determined by your doctor.\nMissed dose\nIf you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.\nStorage\nKeep out of the reach of children.\nDo not keep outdated medicine or medicine no longer needed.\nAsk your healthcare professional how you should dispose of any medicine you do not use.\nStore the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.\nDo not refrigerate or freeze the oral liquid. Throw away any unused mixed medicine after 14 days.\n Detailed Biaxin dosage information\n',NULL,'Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\nCheck with your doctor immediately if any of the following side effects occur:\nLess common\nChills\ncough\nfever\nhoarseness\nlower back or side pain\npainful or difficult urination\nRare\nFever with or without chills\nitching, skin rash\nnausea\nsevere stomach cramps and pain\nstomach tenderness\nunusual bleeding or bruising\nvomiting\nwatery and severe diarrhea, which may also be bloody\nyellow eyes or skin\nIncidence not known\nAnxiety\nblack, tarry stools\nblistering, peeling, or loosening of the skin\nblurred vision\nchest pain or discomfort\nclay-colored stools\nconfusion about identity, place, and time\ncool, pale skin\ndark urine\ndepression\ndifficulty with swallowing\ndizziness\nfainting\nfast, slow, pounding, or irregular heartbeat or pulse\nfeeling of unreality\nfeeling that others are watching you or controlling your behavior\nfeeling that others can hear your thoughts\nfeeling, seeing, or hearing things that are not there\nhives\nincreased hunger\njoint or muscle pain\nlight-colored stools\nloss of appetite\nnightmares\npuffiness or swelling of the eyelids or around the eyes, face, lips, or tongue\nrecurrent fainting\nred skin lesions, often with a purple center\nred, irritated eyes\nredness, swelling, or soreness of the tongue\nseizures\nsense of detachment from self or body\nsevere mood or mental changes\nshakiness\nskin eruptions\nslurred speech\nsore throat\nsores, ulcers, or white spots in the mouth or on the lips\nstomach pain\nswollen glands\ntightness in the chest\nunpleasant breath odor\nunusual behavior\nunusual tiredness or weakness\nvomiting of blood\nSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:\nLess common\nBelching\nbloated or full feeling\nchange in sensation of taste\nexcess air or gas in the stomach or bowels\nheadache\nheartburn\nindigestion\nmild diarrhea\npassing gas\nIncidence not known\nChange in sense of smell\ncontinuing ringing or buzzing or other unexplained noise in the ears\nfeeling of constant movement of self or surroundings\nhearing loss\nlightheadedness\nloss of taste\nmood or mental changes\nsensation of spinning\nshakiness in the legs, arms, hands, or feet\nsore mouth or tongue\nswelling or inflammation of the mouth\ntongue discoloration\ntooth discoloration\ntrouble sleeping\nweight loss\nOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.\nCall your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.\n Biaxin side effects (more detail)\n','Clarithromycin is used to treat bacterial infections in many different parts of the body. It is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori. This medicine is also used to prevent and treat Mycobacterium avium complex (MAC) infection.\nClarithromycin belongs to the class of medicines, known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.\nThis medicine is available only with your doctor\'s prescription.\n','It is very important that your doctor check your or your child\'s progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.\nDo not use this medicine if you or your child are also using astemizole (Hismanal®), cisapride (Propulsid®), lomitapide (Juxtapid®), lovastatin (Mevacor®), pimozide (Orap®), simvastatin (Zocor®), terfenadine (Seldane®), or certain ergot medicines (eg, dihydroergotamine, ergotamine, D.H.E. 45®, Ergomar®, Ergostat®, or Migranal®). If you have kidney or liver disease, do not take this medicine together with colchicine (Colcrys®). Using these medicines together may increase the risk for more serious side effects.\nIf your or your child\'s symptoms do not improve within a few days, or if they become worse, check with your doctor.\nMake sure your doctor knows if you are pregnant or planning to become pregnant. If you become pregnant while using this medicine, tell your doctor right away.\nThis medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you or your child are using this medicine.\nSerious skin reactions can occur with this medicine. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine.\nCheck with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.\nContact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem, such as QT prolongation.\nClarithromycin may increase the risk for heart and blood vessel problems in patients with these conditions. It may occur a year or 10 years after the use of this medicine. Talk to your doctor if you have concerns about this risk.\nThis medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you or your child stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.\nThis medicine may make you dizzy or confused. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.\nDo not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.\n',NULL),(93,'bicalutamide','Usual Adult Dose for Prostate Cancer:\nIn combination with an LHRH analog: 50 mg orally once a day (morning or evening)\nComments:\n-Therapy with this drug should be started at the same time as therapy with an LHRH analog.\n-If a dose is missed, take the next dose at the scheduled time. Do not take the missed dose and do not double the next dose.\nUse: For use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate\n Detailed Bicalutamide dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose at the regular time. Do not use two doses at one time.\nCall your doctor for instructions if you miss an appointment for your LHRH injection.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your other medicines, especially:\na blood thinner (warfarin, Coumadin, Jantoven).\nThis list is not complete. Other drugs may interact with bicalutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Bicalutamide drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to bicalutamide: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nbreast pain or swelling;\nsudden chest pain, wheezing, dry cough, feeling short of breath;\nlow red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;\nliver problems - nausea, upper stomach pain, feeling tired, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), fever, chills;\nhigh blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or\n(if you also take warfarin) unusual bruising or bleeding.\nCommon bicalutamide side effects may include:\nanemia;\nblood in your urine;\nfever, chills, flu-like symptoms;\ntrouble breathing;\nhot flashes;\npain in your back, pelvis, or stomach;\nswelling in your arms, ankles, legs, or feet;\nincreased night-time urination;\nweakness, dizziness; or\nnausea, diarrhea, constipation.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bicalutamide side effects (more detail)\n','Bicalutamide is a prescription medicine belonging to a class of medicines called non-steroidal androgen receptor inhibitors.\nBicalutamide is used to treat prostate cancer that has spread to other parts of the body (metastatic).\nBicalutamide is given in combination with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. LHRH helps prevent the testicles from producing testosterone.\nIt is not known if bicalutamide tablets are safe and effective in children.\n','Bicalutamide can harm an unborn baby if you father a child while using this medicine. Use effective birth control to prevent pregnancy while using bicalutamide and for at least 130 days (about 19 weeks) after your last dose.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to bicalutamide.\nUse effective birth control if your sex partner is able to get pregnant. Bicalutamide can harm an unborn baby if you father a child while using this medicine. Keep using birth control for at least 130 days (about 19 weeks) after your last dose.\nBicalutamide is not for use by women or children.\nThis medicine can cause birth defects if a woman takes it during pregnancy.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\nliver disease; or\ndiabetes.\nHow should I take bicalutamide?\nTake bicalutamide exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nBicalutamide is usually taken once per day in the morning or evening.\nTake the medicine at the same time each day, with or without food.\nLHRH is given as an injection or a tiny implant injected through a needle under the skin around your navel. LHRH injections are given at intervals such as once every 4 weeks. Follow your doctor\'s instructions.\nYou should not stop using bicalutamide unless your doctor tells you to.\nYou will need frequent medical tests.\nStore at room temperature away from moisture and heat.\n','Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.\nBicalutamide could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.\n'),(94,'biktarvy','Usual Adult Dose for HIV Infection:\n1 tablet orally once a day\nUse: As a complete regimen for the treatment of HIV-1 infection in patients with no antiretroviral treatment history or to replace the current antiretroviral regimen in patients virologically-suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen for at least 3 months with no history of treatment failure and no known substitutions associated with resistance to the individual components of this drug\n Detailed Biktarvy dosage information\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.\nGet your prescription refilled before you run out of medicine completely.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nCertain antacids, laxatives, or buffered medicines can make Biktarvy much less effective when taken at the same time. Take your dose on an empty stomach, 2 hours before you take any of these other medicines.\nMany drugs can interact with bictegravir, emtricitabine, and tenofovir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Biktarvy drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Biktarvy: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nkidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath;\nlactic acidosis - muscle pain or weakness, numbness or cold feeling, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, or feeling very weak or tired; or\nliver problems - swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nBiktarvy affects your immune system, which may cause certain side effects (even weeks or months after you\'ve taken this medicine). Tell your doctor if you have:\nsigns of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;\ntrouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or\nswelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.\nCommon Biktarvy side effects may include:\nnausea, diarrhea; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Biktarvy side effects (more detail)\n','Biktarvy contains a combination of bictegravir, emtricitabine, and tenofovir. Bictegravir, emtricitabine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body.\nBiktarvy is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).\nBiktarvy is for use in adults and children who weigh at least 55 pounds (25 kilograms).\nBiktarvy is not a cure for HIV or AIDS.\n','Biktarvy may cause a serious condition called lactic acidosis. Too much lactic acid is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat.\nIf you\'ve ever had hepatitis B, it may become active or get worse after you stop using Biktarvy. You may need frequent liver function tests for several months.\nBefore taking this medicine\nYou should not use Biktarvy if you are allergic to antiviral medicines that contain emtricitabine or tenofovir (such as Atripla, Complera, Emtriva, Descovy, Genvoya, Odefsey, Stribild, or Truvada).\nSome medicines can cause unwanted or dangerous effects when used with Biktarvy. Your doctor may need to change your treatment plan if you also use:\ndofetilide; or\nrifampin.\nTell your doctor if you have ever had:\nliver disease (especially cirrhosis or hepatitis B); or\nkidney disease.\nTell your doctor if you are pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines to control your infection. Your name may be listed on a pregnancy registry to track the effects of Biktarvy on the baby.\nWomen with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.\nHow should I take Biktarvy?\nTake Biktarvy exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nBiktarvy is a complete regimen and is not for use with other antiviral medications.\nYou may take Biktarvy with or without food. If you take a multivitamin or mineral supplement that contains iron or calcium, take it with food at the same time you take Biktarvy.\nYou will need frequent medical tests.\nStore in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.\nIf you\'ve ever had hepatitis B, this virus may become active or get worse in the months after you stop using Biktarvy. You may need frequent liver function tests while using this medicine and for several months after your last dose.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(95,'biotin',NULL,'Taking certain medicines can lower your blood levels of biotin, which could affect your biotin dose needs. Ask a doctor or pharmacist before using biotin with any other medications, especially:\ncarbamazepine;\nphenobarbital;\nphenytoin; or\nprimidone.\nThis list is not complete. Other drugs may affect biotin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\nDoes Biotin interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCommon side effects may include upset stomach or diarrhea.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Biotin side effects (more detail)\n','Biotin is a form of vitamin B found in foods. Biotin helps the body break down fats, carbohydrates, and proteins.\nBiotin has been used in alternative medicine as a likely effective aid in treating or preventing biotin deficiency. Biotin deficiency can be caused by malnutrition, rapid weight loss, long-term tube feeding, and other medical conditions.\nBiotin has also been used to treat seborrhea (skin rash) in babies. However, research has shown that biotin may not be effective in treating this condition.\nOther uses not proven with research have included treating brittle nails or thinning hair, diabetes, nerve pain, and other conditions.\nIt is not certain whether biotin is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Biotin should not be used in place of medication prescribed for you by your doctor.\nBiotin is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.\nBiotin may also be used for purposes not listed in this product guide.\n','Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use this product if you are allergic to biotin.\nBefore using biotin, talk to your healthcare provider. Your dose needs may be different:\nif you have kidney disease;\nif you have had stomach surgery; or\nif you smoke.\nAsk a doctor before using biotin if you are pregnant or breastfeeding. Your dose needs may be different during pregnancy or while you are nursing.\nDo not give any herbal/health supplement to a child without medical advice.\n','Follow your healthcare provider\'s instructions about any restrictions on food, beverages, or activity.\n'),(96,'bisacodyl',NULL,NULL,NULL,NULL,NULL,NULL),(97,'bismuth-subsalicylate','Use exactly as directed on the label, or as prescribed by your doctor.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nYou must chew the chewable tablet before you swallow it.\nDrink plenty of liquids while you are taking bismuth subsalicylate.\nDo not take more than 8 doses in one day (24 hours).\nCall your doctor if you still have diarrhea after 2 days of using  bismuth subsalicylate.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using bismuth subsalicylate.\nStore at room temperature away from moisture and heat. Do not freeze.\n Detailed Bismuth subsalicylate dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nSince bismuth subsalicylate is used when needed, you may not be on a dosing schedule. Skip any missed dose if it\'s almost time for your next dose. Do not use two doses at one time.\nDo not take more than 8 doses per day.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include weakness, depression, anxiety, feeling irritable, problems with balance or coordination, confusion, tremors, or jerky muscle movements.\n','Ask a doctor or pharmacist before using bismuth subsalicylate with any other medications, especially:\narthritis medicine;\ngout medicine;\ninsulin or oral diabetes medications; or\na blood thinner--warfarin, Coumadin, Jantoven.\nThis list is not complete. Other drugs may affect bismuth subsalicylate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Bismuth subsalicylate drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nStop taking  bismuth subsalicylate and call your doctor at once if you have:\nchanges in behavior with nausea and vomiting;\nhearing loss or ringing in your ears;\ndiarrhea lasting longer than 2 days; or\nworsened stomach symptoms.\nBismuth subsalicylate can cause you to have a black or darkened tongue. This is a harmless side effect.\nCommon side effects include:\nconstipation; or\ndark colored stools.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bismuth subsalicylate side effects (more detail)\n','Bismuth subsalicylate is used to treat diarrhea, nausea, heartburn, indigestion, gas, or upset stomach.\nBismuth subsalicylate may also be used for purposes not listed in this medication guide.\n','You should not use  bismuth subsalicylate if you have bleeding problems, a stomach ulcer, blood in your stools, or if you are allergic to aspirin or other salicylates.\nDo not give this medicine to a child or teenager with a fever, flu symptoms, or chickenpox.\nBefore taking this medicine\nYou should not use bismuth subsalicylate if you are allergic to it, or if you have:\nblack or bloody stools;\na stomach ulcer;\nbleeding problems; or\nif you are allergic to salicylates such as aspirin, Doan\'s Extra Strength, Salflex, Tricosal, and others.\nDo not give this medicine to a child or teenager with a fever, flu symptoms, or chickenpox. Salicylates can cause Reye\'s syndrome, a serious and sometimes fatal condition in children.\nAsk a doctor or pharmacist if this medicine is safe to use if you have:\nmucus in your stools; or\nif you currently have a fever.\nAsk a doctor before using this medicine if you are pregnant or breastfeeding.\nDo not give this medicine to a child younger than 12 years old without medical advice.\n','Ask a doctor or pharmacist before taking other antacids or diarrhea medicine, or taking medicine that may contain a salicylate (such as aspirin, salsalate, magnesium salicylate, choline salicylate, diflunisal, Ecotrin, Tricosal, Trilisate, and others).\n'),(98,'bisoprolol','Take bisoprolol exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nDo not skip doses or stop taking bisoprolol without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems.\nIf you need surgery, tell the surgeon ahead of time that you are using bisoprolol.\nYour blood pressure will need to be checked often.\nKeep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.\nStore bisoprolol at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\n Detailed Bisoprolol dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your current medicines and any you start or stop using, especially:\ninsulin or oral diabetes medicine;\nrifampin; or\nheart or blood pressure medicine--clonidine, digitalis, digoxin, diltiazem, reserpine, or verapamil.\nThis list is not complete. Other drugs may interact with bisoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Bisoprolol drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to bisoprolol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nshortness of breath (even with mild exertion), swelling, rapid weight gain;\nslow heart rate;\npounding heartbeats or fluttering in your chest;\nnumbness, tingling, or cold feeling in your hands or feet;\na light-headed feeling, like you might pass out;\neye pain, vision problems; or\nbronchospasm (wheezing, chest tightness, trouble breathing).\nCommon bisoprolol side effects may include:\nheadache;\nfeeling tired;\nsleep problems (insomnia);\njoint pain;\nswelling; or\ncold symptoms such as stuffy nose, runny nose, cough, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bisoprolol side effects (more detail)\n','Bisoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).\nBisoprolol is used to treat hypertension (high blood pressure).\nBisoprolol may also be used for purposes not listed in this medication guide.\n','Do not skip doses or stop taking bisoprolol without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems.\nIf you need to have any type of surgery, tell the surgeon ahead of time that you are using this medicine.\nYou should not use bisoprolol if you have a serious heart condition such as \"AV block,\" severe heart failure, or slow heartbeats that have caused you to faint.\nKeep using bisoprolol as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nBefore taking this medicine\nYou should not use bisoprolol if you you are allergic to it, or if you have a serious heart condition such as:\n\"AV block\";\nsevere heart failure; or\nslow heartbeats that have caused you to faint.\nTo make sure bisoprolol is safe for you, tell your doctor if you have:\ncongestive heart failure or other heart problems;\ncoronary artery disease;\ncirculation problems (such as Peripheral Vascular Disease or Raynaud\'s syndrome);\nasthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;\ndiabetes (taking bisoprolol can make it harder for you to tell when you have low blood sugar);\nliver or kidney disease;\na thyroid disorder; or\na history of allergies.\nIt is not known whether bisoprolol is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether bisoprolol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nBisoprolol is not approved for use by anyone younger than 18 years old.\n','This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\nMinimize drinking alcohol. It can increase some of the side effects of bisoprolol.\n'),(99,'blincyto','Blincyto is given around the clock (continuous) using an infusion pump. A healthcare provider will give you this injection. The medicine enters the body through a catheter placed into a vein.\nYou may receive your first dose of Blincyto in a hospital or clinic setting to quickly treat any serious side effects. You may also need to be in a hospital if you start using the medicine again after not using it for a short time.\nYour injections will be prepared at the pharmacy and you will receive the medicine in IV bags. Keep the IV bags in their original package and do not open the package. Store it in the refrigerator, protected from light. Do not freeze. Each IV bag will be unpackaged and prepared by a healthcare provider.\nRead and carefully follow any Instructions for Use provided with your medicine. Do not use Blincyto if you don\'t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.\nBlincyto is usually given around the clock. Your doctor will determine how often you need to use this medicine, and for how long.\nDo not change the settings on your infusion pump without the assistance of a healthcare professional.\nYou may be given medication to prevent certain side effects while you are receiving Blincyto.\nWhen it is time to change IV bags, call your doctor or pharmacist if you do not have a new IV bag ready to attach to the infusion pump.\nBe sure to keep the skin clean around your catheter (IV) to reduce the risk of infection.\nBlincyto can increase your risk of bleeding or infection by changing the way your immune system works. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.\n Detailed Blincyto dosage information\nWhat happens if I miss a dose?\nSince dosing and infusion pump programming is administered by a healthcare professional, you are not likely to miss a dose.\nCall your pharmacist for new medicine if you do not receive your IV bags on time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include fever, tremors, and headache.\n','Other drugs may interact with blinatumomab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Blincyto drug interactions (more detail)\n','Some side effects may occur during the injection. Tell your caregiver right away if you feel weak, nauseated, light-headed, tired, chilled or feverish, or you have a headache, muscle pain, skin rash, wheezing, trouble breathing, or swelling in your face.\nGet emergency medical help if you signs of an allergic reaction to Blincyto: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nAlso tell your caregivers or seek emergency medical attention if you have signs of life-threatening nerve problems, such as:\nslurred speech, confusion;\nproblems with balance;\na seizure (convulsions); or\nloss of consciousness.\nA serious side effect of blinatumomab is called cytokine release syndrome (CRS). Tell your caregivers right away if you have signs of this condition: fever, chills, trouble breathing, body aches, vomiting, diarrhea, or feeling light-headed. Your caregivers will have medication available to quickly treat CRS if it occurs.\nCall your doctor at once if you have:\nsevere pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;\nlow potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;\nlow blood cell counts - fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or\nsigns of tumor cell breakdown - confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.\nCommon Blincyto side effects may include:\nreactions during the injection;\nlow blood cell counts;\nfever, infections; or\nheadache.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Blincyto side effects (more detail)\n','Blincyto (blinatumomab) is used to treat a certain type of acute lymphoblastic leukemia in adults and children.\nBlincyto is given after other cancer treatments have been tried without success.\nBlincyto was approved by the US Food and Drug Administration (FDA) on an \"accelerated\" basis. In clinical studies, some people responded to this medicine, but further studies are needed.\nAcute lymphoblastic leukemia is a cancer of the blood in which a particular kind of white blood cell is growing out of control.\n','Some side effects may occur during the Blincyto injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, chilled or feverish, or if you have a headache, skin rash, trouble breathing, or swelling in your face.\nA serious side effect of Blincyto is called cytokine release syndrome, which causes fever, chills, trouble breathing, vomiting, and other symptoms. Your caregivers will have medication available to quickly treat this condition if it occurs.\nAlso tell your caregivers or seek emergency medical attention if you have slurred speech, confusion, loss of balance, or seizure (convulsions). These could be signs of life-threatening nerve problems.\nBefore taking this medicine\nYou should not use Blincyto if you are allergic to blinatumomab.\nTo make sure Blincyto is safe for you, tell your doctor if you have:\nnerve problems (neurologic disorder), such as seizures, confusion, trouble speaking, or problems with balance;\nchemotherapy, or radiation treatment to your brain;\nany type of infection; or\na reaction to a blinatumomab injection.\nBefore using Blincyto, tell your doctor if you have recently received a vaccine or if you are scheduled for a booster dose.\nYou may need to have a negative pregnancy test before starting this treatment.\nDo not use Blincyto if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using Blincyto and for at least 48 hours after your last dose.\nYou should not breastfeed while using this medicine and for at least 48 hours after your last dose.\n','Do not receive a \"live\" vaccine while using Blincyto, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles). Ask your doctor how soon it is safe for you to receive a vaccine after you stop using this medicine.\nAvoid driving or hazardous activity until you know how Blincyto will affect you. Your reactions could be impaired.\n'),(100,'boniva','Usual Adult Dose for Osteoporosis:\nOral:\n150 mg orally once a month on the same day each month\nIV Injection:\n3 mg by IV injection over 15 to 30 seconds every three months.\nComments:\n-The IV injection should not be administered more frequently than once every 3 months.\n-Obtain serum creatinine prior administration of each IV injection.\n-Perform a routine oral examination prior administration of IV injection\nUses: Treatment and prevention of postmenopausal osteoporosis, to increase bone mineral density (BMD) and to reduce the incidence of vertebral fractures\nUsual Adult Dose for Prevention of Osteoporosis:\nOral:\n150 mg orally once a month on the same day each month\nIV Injection:\n3 mg by IV injection over 15 to 30 seconds every three months.\nComments:\n-The IV injection should not be administered more frequently than once every 3 months.\n-Obtain serum creatinine prior administration of each IV injection.\n-Perform a routine oral examination prior administration of IV injection\nUses: Treatment and prevention of postmenopausal osteoporosis, to increase bone mineral density (BMD) and to reduce the incidence of vertebral fractures\n Detailed Boniva dosage information\nWhat happens if I miss a dose?\nBoniva tablets: If you forget to take a tablet first thing in the morning on your scheduled day, do not take it later in the day. Wait until the next morning to take the missed dose. Then return to your regular monthly schedule on your chosen dose day. If your next scheduled dose is less than 7 days away, wait until then and skip the missed dose. Do not take two (2) doses in one week.\nBoniva injections: Call your doctor for instructions if you miss an appointment for your injection.\nWhat happens if I overdose?\nFor Boniva tablets: Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.\nSince the injections are given by a healthcare professional in a medical setting, an overdose is unlikely to occur.\n','Tell your doctor about all your current medicines and any you start or stop using, especially:\naspirin; or\nNSAIDs (nonsteroidal anti-inflammatory drugs) - ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.\nThis list is not complete. Other drugs may interact with ibandronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Talk with your doctor about the best dosing schedule for your other medicines.\n Boniva drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Boniva: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using this medicine and call your doctor at once if you have:\nchest pain, new or worsening heartburn;\ndifficulty or pain when swallowing;\npain or burning under the ribs or in the back;\nsevere heartburn, burning pain in your upper stomach, or coughing up blood;\nnew or unusual pain in your thigh or hip;\njaw pain, numbness, or swelling;\nsevere joint, bone, or muscle pain; or\nlow calcium levels - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).\nCommon Boniva side effects may include:\nheartburn, stomach pain, diarrhea;\nback pain, bone pain, muscle or joint pain;\npain in your arms or legs;\nheadache; or\nfever, chills, tiredness, flu-like symptoms.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Boniva side effects (more detail)\nBefore taking this medicine\nYou should not use Boniva if you are allergic to ibandronate, or if you have:\nsevere kidney disease; or\nlow blood levels of calcium (hypocalcemia).\nDo not take an Boniva tablet if you have problems with your esophagus, or if you cannot sit upright or stand for at least 60 minutes. Ibandronate can cause serious problems in the stomach or esophagus. You must stay upright for at least 1 full hour after taking this medicine.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\ntrouble swallowing;\nproblems with your stomach or digestion;\nhypocalcemia;\na dental problem (you may need a dental exam before you begin using Boniva);\nkidney disease; or\nany condition that makes it hard for your body to absorb nutrients from food (malabsorption).\nIn rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Boniva, the more likely you are to develop this condition.\nOsteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.\nTalk with your doctor about the risks and benefits of using this medication.\nIt is not known whether ibandronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether ibandronate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nHow should I use Boniva?\nUse Boniva exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nBoniva tablets are taken once per month. The injection is given into a vein through an IV once every 3 months. The tablets can be taken at home, but a healthcare provider must give the injection.\nTake the tablet first thing in the morning, at least 60 minutes before you eat or drink anything or take any other medicine. Take the medicine on the same day each month and always first thing in the morning.\nTake the tablet with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.\nDo not crush, chew, or suck on a tablet. Swallow it whole.\nFor at least 60 minutes (1 full hour) after taking a tablet:\nDo not lie down or recline.\nDo not take any other medicine including vitamins, calcium, or antacids.\nPay special attention to your dental hygiene while using Boniva. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using this medicine.\nBoniva is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor\'s instructions very closely.\nStore at room temperature away from moisture and heat.\nYour doctor will determine how long to treat you with this medicine. Ibandronate is often given for only 3 to 5 years.\n','Boniva (ibandronate) is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.\nBoniva is prescription medicine used to treat or prevent osteoporosis in women after menopause. Ibandronate helps increase bone mass and helps reduce the chance of having a spinal fracture.\nIt is not known how long Boniva works for the treatment and prevention of osteoporosis. You should see your doctor regularly to determine if this medicine is still right for you.\n','You should not use Boniva if you have severe kidney disease or low levels of calcium in your blood.\nDo not take a tablet if you have problems with your esophagus, or if you cannot sit upright or stand for at least 60 minutes after taking the tablet.\nBoniva tablets can cause serious problems in the stomach or esophagus. Stop taking Boniva and call your doctor at once if you have chest pain, new or worsening heartburn, or pain when swallowing.\nAlso call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, or severe pain in your joints, bones, or muscles.\n','Avoid taking any other medicines for at least 60 minutes after taking Boniva. This includes vitamins, calcium, and antacids. Some medicines can make it harder for your body to absorb ibandronate.\nAvoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely.\nAvoid drinking large amounts of alcohol. Heavy drinking can also cause bone loss.\n'),(101,'botox','Botox injections should be given only by a trained medical professional, even when used for cosmetic purposes.\nThis medicine is injected into a muscle by a healthcare provider. Botox injections should be spaced at least 3 months apart.\nBotox injections may be given into more than one area at a time, depending on the condition being treated.\nWhile receiving injections for eye muscle conditions, you may need to use eye drops, ointment, a special contact lens or other device to protect the surface of your eye. Follow your doctor\'s instructions.\nIf you are being treated for excessive sweating, shave your underarms about 24 hours before your injection. Do not apply antiperspirant or deodorant for 24 hours before or after you receive the injection. Avoid exercise and hot foods or beverages within 30 minutes before the injection.\nIt may take up to 2 weeks after injection before neck muscle spasm symptoms begin to improve. You may notice the greatest improvement after 6 weeks.\nIt may take only 1 to 3 days after injection before eye muscle spasm symptoms begin to improve. You may notice the greatest improvement after 2 to 6 weeks.\nThe effects of a Botox injection are temporary. Your symptoms may return completely within 3 months. After repeat injections, it may take less and less time before your symptoms return, especially if your body develops antibodies to the botulinum toxin.\nDo not seek botulinum toxin injections from more than one medical professional at a time. If you switch healthcare providers, tell your new provider how long it has been since your last botulinum toxin injection.\nUsing this medication more often than prescribed will not make it more effective and may result in serious side effects.\n Detailed Botox dosage information\nWhat happens if I miss a dose?\nSince botulinum toxin has a temporary effect and is given at widely spaced intervals, missing a dose is not likely to be harmful.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may not appear right away, but can include muscle weakness, trouble swallowing, and weak or shallow breathing.\n','Tell your doctor about all your other medicines, especially:\na muscle relaxer;\ncold or allergy medicine;\nsleep medicine;\nan injectable antibiotic; or\na blood thinner - warfarin, Coumadin, Jantoven.\nThis list is not complete. Other drugs may affect Botox, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Botox drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Botox: hives, itching; wheezing, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.\nThe botulinum toxin contained in Botox can spread to other body areas beyond where it was injected. This has caused serious life-threatening side effects in some people receiving botulinum toxin injections, even for cosmetic purposes.\nCall your doctor at once if you have any of these side effects (up to several hours or several weeks after an injection):\nunusual or severe muscle weakness (especially in a body area that was not injected with the medication);\nloss of bladder control;\nhoarse voice, trouble talking or swallowing;\ndrooping eyelids or eyebrows;\nvision changes, eye pain, severely dry or irritated eyes (your eyes may also be more sensitive to light);\nchest pain or pressure, pain spreading to your jaw or shoulder, irregular heartbeats;\npain or burning when you urinate, trouble emptying your bladder;\nsore throat, cough, chest tightness, shortness of breath; or\neyelid swelling, crusting or drainage from your eyes, problems with vision.\nCommon Botox side effects may include:\npainful or difficult urination;\nheadache, neck pain, back pain, pain in your arms or legs;\ncold symptoms such as stuffy nose, sneezing, sore throat;\ntrouble swallowing;\nfever, chills, body aches, flu symptoms;\nincreased sweating in areas other than the underarms; or\nbruising, bleeding, pain, redness, or swelling where the injection was given.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Botox side effects (more detail)\n','Botox (onabotulinumtoxinA) is made from the bacteria that causes botulism. Botulinum toxin blocks nerve activity in the muscles.\nBotox is used in adults to treat cervical dystonia (abnormal head position and neck pain).\nBotox is also used to treat muscle stiffness (spasticity) of the arms, hands, legs, and feet in adults and children who are at least 2 years old.\nBotox is used to treat certain eye muscle conditions caused by nerve disorders in adults and children who are at least 12 years old. This includes uncontrolled blinking or spasm of the eyelids, and a condition in which the eyes do not point in the same direction (strabismus).\nBotox is used in adults to treat overactive bladder and incontinence (urine leakage) that has not been helped by other medication. Botox may be used to treat incontinence caused by nerve disorders such as spinal cord injury or multiple sclerosis.\nBotox is used to treat overactive bladder due to a neurologic disease (such as multiple sclerosis or spinal cord injury) in children 5 years of age and older when another type of medicine (anticholinergic) does not work well enough or cannot be taken.\nBotox is used in adults to prevent chronic migraine headaches that occur more than 15 days per month and last 4 hours or longer. Botox should not be used to treat a common tension headache.\nBotox is also used to treat severe underarm sweating (hyperhidrosis) in adults.\nBotox Cosmetic is used to temporarily lessen the appearance of facial wrinkles in adults.\n','You should not use Botox if you have an infection in the area where the medicine will be injected. This medicine should not be used to treat overactive bladder or incontinence if you have a current bladder infection or if you are unable to urinate (unless you routinely use a catheter).\nThe botulinum toxin contained in Botox can spread to other body areas beyond where it was injected. This can cause serious life-threatening side effects.\nCall your doctor at once if you have a hoarse voice, drooping eyelids, vision problems, severe eye irritation, severe muscle weakness, loss of bladder control, or trouble breathing, talking, or swallowing.\nBefore taking this medicine\nYou should not be treated with Botox if you are allergic to botulinum toxin, or if you have:\nan infection in the area where the medicine will be injected; or\n(for overactive bladder and incontinence) if you have a current bladder infection or if you are unable to urinate and you do not routinely use a catheter.\nTo make sure Botox is safe for you, tell your doctor if you have ever had:\nother botulinum toxin injections such as Dysport or Myobloc (especially in the last 4 months);\namyotrophic lateral sclerosis (ALS, or \"Lou Gehrig\'s disease\");\nmyasthenia gravis;\nLambert-Eaton syndrome;\na side effect after prior use of botulinum toxin;\na breathing disorder such as asthma or emphysema;\nproblems with swallowing;\nfacial muscle weakness (droopy eyelids, weak forehead, trouble raising your eyebrows);\na change in the normal appearance of your face;\nbleeding problems; or\nsurgery (especially on your face).\nBotox is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\n','Botox may impair your vision or depth perception. Avoid driving or hazardous activity until you know how this medicine will affect you.\nAvoid going back to your normal physical activities too quickly after receiving an injection.\n'),(102,'breo-ellipta','Use Breo Ellipta inhalation powder exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nBreo Ellipta is not a rescue medicine for asthma or bronchospasm attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.\nBreo Ellipta is a powder that comes with a special inhaler device preloaded with blister packs containing measured doses of the medicine. The device opens and loads a blister of Breo Ellipta each time you use the inhaler. Follow the patient instructions provided with the inhaler device.\nUse the medicine at the same time each day, and not more than once in a 24-hour period.\nYour dose needs may change due to surgery, illness, stress, or a recent asthma attack. Do not change your Breo Ellipta dose or dosage schedule without your doctor\'s advice.\nAlways rinse out your mouth with water after using the inhaler device, to help prevent thrush (a fungal infection in the mouth or throat).\nWhile using Breo Ellipta, your doctor will need to check your lung function on a regular basis. Your vision and your bone mineral density may also need to be checked.\nOnce your asthma is under control, your doctor may want you to stop using Breo Ellipta. Keep all follow-up appointments and do not stop using the medicine unless your doctor tells you to.\nStore Breo Ellipta at room temperature away from moisture, heat, and light. Keep the inhaler device in the sealed foil tray until ready to start using it.\nThrow the inhaler device away 6 weeks after you have taken it out of the foil pouch, or if the dose indicator shows a zero, whichever comes first.\n Detailed Breo Ellipta dosage information\nWhat happens if I miss a dose?\nUse the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include chest pain, fast heart rate, and feeling shaky or short of breath.\nLong term use of an inhaled steroid can lead to glaucoma, cataracts, thinning skin, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nMany drugs can interact with fluticasone and vilanterol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Breo Ellipta drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Breo Ellipta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nwheezing, choking, or other breathing problems after using this medicine;\nchest pain, fast or pounding heartbeats, pounding in your neck or ears;\nsores or white patches in your mouth and throat, pain when swallowing;\nfever, chills, cough with yellow or green mucus;\nblurred vision, tunnel vision, eye pain, or seeing halos around lights.\nhigh blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;\nlow potassium level - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or\nsigns of a hormonal disorder - worsening tiredness or muscle weakness, feeling light-headed, nausea, vomiting.\nCommon Breo Ellipta side effects may include:\nheadache, back pain, joint pain;\nfever, flu symptoms;\nincreased blood pressure;\nrunny or stuffy nose, sore throat, cough; or\na hoarse voice.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Breo Ellipta side effects (more detail)\n','Breo Ellipta inhalation powder contains a combination of fluticasone and vilanterol. Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation. Vilanterol is a bronchodilator that works by relaxing muscles in the airways to improve breathing.\nBreo Ellipta is a once-daily combination medicine used in adults with asthma or COPD (chronic obstructive pulmonary disease), to improve symptoms and prevent bronchospasm or asthma attacks.\nIn people with COPD, Breo Ellipta is for long-term treatment. In people with asthma, this medicine is for short-term treatment until symptoms are well-controlled with with other medicines.\nVilanterol when used alone may increase the risk of death in people with asthma. However, this risk is not increased when fluticasone and vilanterol are used together as a combination product.\n','Breo Ellipta is not a rescue medicine. It will not work fast enough to treat an asthma or bronchospasm attack.\nTell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Breo Ellipta may interact with other medicines and this may cause serious side effects. Tell your healthcare provider if you take antifungal or anti-HIV medicines.\nBefore taking this medicine\nYou should not use Breo Ellipta if you are allergic to fluticasone, vilanterol, or milk proteins.\nFluticasone can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.\nTo make sure Breo Ellipta is safe for you, tell your doctor if you have:\nglaucoma or cataracts;\na weak immune system;\nheart disease, high blood pressure;\nliver disease;\na thyroid disorder;\na seizure;\ndiabetes;\nany type of infection (bacterial, fungal, viral, or parasitic); or\nosteoporosis.\nLong-term use of steroids may lead to bone loss (osteoporosis), especially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis. Talk with your doctor about your risk.\nTell your doctor if you are pregnant. It is not known whether Breo Ellipta will harm an unborn baby. However, having untreated or uncontrolled asthma during pregnancy may cause complications such as low birth weight, premature birth, or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating asthma may outweigh any risks to the baby.\nIt may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.\nBreo Ellipta is not approved for use by anyone younger than 18 years old.\n','Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using a steroid such as fluticasone.\nDo not use a second inhaled bronchodilator unless your doctor tells you to. This includes formoterol (Perforomist, Symbicort, Bevespi, Dulera), arformoterol (Brovana), indacaterol (Arcapta), olodaterol (Striverdi, Stiolto Respimat), salmeterol (Serevent), or vilanterol (Anoro Ellipta).\n'),(103,'breztri-aerosphere','Read the step-by-step instructions that come with your prescription.\nBefore using Breztri Aerosphere, make sure your healthcare provider has taught you how to use the inhaler and you understand how to use it correctly.\nUse this medicine exactly as your healthcare provider tells you to use it. Do not use more often than prescribed.\nUse 2 inhalations of Breztri Aerosphere, 2 times each day (2 puffs in the morning and 2 puffs in the evening).\nDo not take more than 2 inhalations of Breztri Aerosphere 2 times each day.\nIf a dose (2 puffs) is missed, it should be taken as soon as possible and the next dose should be taken at the usual time. Do not take more than one dose to make up for a forgotten dose.\nRinse your mouth with water and spit the water out after each dose (2 puffs). Do not swallow the water. This will help to reduce the chance of getting a fungus infection (thrush) in the mouth and throat.\nIf you take too much Breztri Aerosphere, call your healthcare provider or go to the nearest hospital emergency room right away if you have any unusual symptoms, such as worsening shortness of breath, chest pain, increased heart rate, or shakiness.\nDo not spray Breztri Aerosphere in your eyes. If Breztri Aerosphere gets in your eyes, rinse them well with water. If redness continues, call your healthcare provider.\nDo not use other medicines that contain a LABA or an anticholinergic for any reason. Ask your healthcare provider or pharmacist if any of your other medicines are LABA or anticholinergic containing medicines.\nDo not change or stop any medicines used to control or treat your breathing problems. Your healthcare provider will change your medicines as needed.\nBreztri Aerosphere does not relieve sudden breathing problems and you should not take extra doses to relieve sudden symptoms. Always have a rescue inhaler with you to treat sudden symptoms. If you do not have a rescue inhaler, call your healthcare provider to have one prescribed for you.\nCall your healthcare provider or get emergency medical care right away if:\nyour breathing problems get worse.\nyou need to use your rescue inhaler more often than usual.\nyour rescue inhaler does not work as well to relieve your symptoms.\n Detailed Breztri Aerosphere dosage information\n',NULL,'Breztri Aerosphere can cause serious side effects, including:\nfungal infection in your mouth or throat (thrush). Rinse your mouth with water without swallowing after using Breztri Aerosphere to help reduce your chance of getting thrush.\npneumonia. People with COPD have a higher chance of getting pneumonia. Breztri Aerosphere may increase your chance of getting pneumonia. Call your healthcare provider if you notice any of the following symptoms:\nincrease in mucus (sputum) production\nchange in mucus color\nfever\nchills\nincreased cough\nincreased breathing problems\nweakened immune system and increased chance of getting infections (immunosuppression).\nreduced adrenal function (adrenal insufficiency). Adrenal insufficiency is a condition where the adrenal glands do not make enough steroid  hormones. This can happen when you stop taking oral corticosteroid medicines (such as prednisone) and start taking a medicine containing an ICS (such as Breztri Aerosphere). During this transition period, when your body is under stress from fever, trauma (such as a car accident), infection, surgery, or worse COPD symptoms, adrenal insufficiency can get worse and may cause death.\nSymptoms of adrenal insufficiency include:\nfeeling tired\nlack of energy\nweakness\nnausea and vomiting\nlow blood pressure (hypotension)\nsudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop taking Breztri Aerosphere and call your healthcare provider right away.\nserious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:\nrash\nhives\nswelling of your face, mouth, and tongue\nbreathing problems\neffects on your heart.\nincreased blood pressure\na fast or irregular heartbeat\nchest pain\neffects on your nervous system.\ntremor\nnervousness\nbone thinning or weakness (osteoporosis).\nnew or worsened eye problems including acute narrow-angle glaucoma and cataracts.\nAcute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms of acute narrow-angle glaucoma may include:\neye pain or discomfort\nnausea or vomiting\nblurred vision\nseeing halos or bright colors around lights\nred eyes\nIf you have these symptoms, call your healthcare provider right away before taking another dose.\nurinary retention. People who take Breztri Aerosphere may develop new or worsening urinary retention. Symptoms of urinary retention may include:\ndifficulty urinating\nurinating frequently\npainful urination\nurination in a weak stream or drips\nIf you have these symptoms of urinary retention, stop taking Breztri Aerosphere and call your healthcare provider right away before taking another dose.\nchanges in laboratory blood values, including high levels of blood sugar (hyperglycemia) and low levels of potassium (hypokalemia). Low levels of potassium may cause symptoms of muscle spasm, muscle weakness, or abnormal heart rhythm.\nCommon side effects include:\nupper respiratory tract infection\npneumonia\nback pain\nthrush in your mouth and throat. Rinse your mouth with water without swallowing after use to help prevent this.\njoint pain\nflu\nheadache\nhigh blood sugar levels\nmuscle spasms\ncough\ninflammation of the sinuses\ndiarrhea\nhoarseness\npainful and frequent urination (signs of a urinary tract infection)\nnausea\ndifficulty sleeping\nfeeling anxious\nawareness of your heart beating (palpitations)\nTell your healthcare provider about any side effect that bothers you or that does not go away.\nThese are not all the possible side effects. Ask your healthcare provider or pharmacist for more information.\nCall your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088. You may also report side effects to AstraZeneca at 1-800-236-9933.\n Breztri Aerosphere side effects (more detail)\nHow should I store Breztri Aerosphere?\nStore Breztri Aerosphere at room temperature between 68ºF to 77ºF (20ºC to 25ºC). Keep in a dry place away from heat and sunlight.\nStore Breztri Aerosphere in the unopened foil pouch and only open when ready for use.\nDo not put a hole in the canister.\nDo not use or store Breztri Aerosphere near heat or a flame. Temperatures above 120ºF (49ºC) may cause the canister to burst.\nDo not throw the canister into a fire or an incinerator.\nThrow away Breztri Aerosphere 3 months after you open the foil pouch (for the 120-inhalation canister), or 3 weeks after you open the foil pouch (for the 28-inhalation canister), or when the dose indicator reaches zero “0”, whichever comes first.\nKeep Breztri Aerosphere and all medicines out of the reach of children.\nGeneral information about the safe and effective use of Breztri Aerosphere.\nMedicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same condition that you have. It may harm them.\nYou can ask your healthcare provider or pharmacist for information that is written for healthcare professionals.\nWhat are the ingredients in Breztri Aerosphere?\nActive ingredients: micronized budesonide, micronized glycopyrrolate, and micronized formoterol fumarate\nInactive ingredients: hydrofluoroalkane (HFA 134a) and porous particles (comprised of DSPC [1,2-Distearoyl-sn-glycero-3-phosphocholine] and calcium chloride)\n','Breztri Aerosphere combines 3 medicines, an inhaled corticosteroid (ICS) medicine (budesonide), an anticholinergic medicine (glycopyrrolate), and a long-acting beta2-adrenergic agonist (LABA) medicine (formoterol fumarate) in 1 inhaler, delivered as a propelled spray.\nICS medicines such as budesonide help to decrease inflammation in the lungs. Inflammation in the lungs can lead to breathing problems.\nAnticholinergic medicines, such as glycopyrrolate and LABA medicines, such as formoterol fumarate help the muscles around the airways in your lungs stay relaxed to prevent symptoms, such as wheezing, cough, chest tightness, and shortness of breath. These symptoms can happen when the muscles around the airways tighten. This makes it hard to breathe.\nBreztri Aerosphere is a prescription medicine used long term to treat people with chronic obstructive pulmonary disease (COPD). COPD is a chronic lung disease that includes chronic bronchitis, emphysema, or both.\nBreztri Aerosphere is used as 2 inhalations, 2 times each day (2 puffs in the morning and 2 puffs in the evening) to improve symptoms of COPD for better breathing and to reduce the number of flare-ups (the worsening of your COPD symptoms for several days).\nBreztri Aerosphere is not for the treatment of asthma. It is not known if this medicine is safe and effective in people with asthma. Breztri Aerosphere contains formoterol fumarate. LABA medicines such as formoterol fumarate when used alone increase the risk of hospitalizations and death from asthma problems. Breztri Aerosphere contains an ICS, an anticholinergic, and a LABA. When an ICS and LABA are used together, there is not a significant risk in hospitalizations and deaths from asthma problems.\nBreztri Aerosphere is not to be used to relieve sudden breathing problems and will not replace a rescue inhaler. Always have a rescue inhaler (an inhaled, short-acting bronchodilator) with you to treat sudden breathing problems. If you do not have a rescue inhaler, contact your healthcare provider to have one prescribed for you.\nBreztri Aerosphere should not be used in children. It is not known if this medicine is safe and effective in children.\nWho should not use Breztri Aerosphere?\nDo not use Breztri Aerosphere if you are allergic to budesonide, glycopyrrolate, formoterol, or any of the other ingredients. See What are the ingredients in Breztri Aerosphere? at the end of this page for a complete list of ingredients.\n',NULL,NULL),(104,'brilinta','Usual Adult Dose for Acute Coronary Syndrome:\nFollowing an acute coronary syndrome (ACS) event:\nLoading dose: 180 mg orally once\nMaintenance dose: 90 mg orally twice a day for 1 year\nMaintenance dose after 1 year: 60 mg orally twice a day\nComments:\n-This drug should be taken in conjunction with a daily maintenance dose of aspirin 75 to 100 mg orally once a day.\n-For at least the first 12 months following ACS, this drug is superior to clopidogrel.\nUses:\n-To reduce the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction.\n-To reduce the rate of stent thrombosis in patients who have been stented for treatment of ACS.\nUsual Adult Dose for Prevention of Atherothrombotic Events:\nFollowing an acute coronary syndrome (ACS) event:\nLoading dose: 180 mg orally once\nMaintenance dose: 90 mg orally twice a day for 1 year\nMaintenance dose after 1 year: 60 mg orally twice a day\nComments:\n-This drug should be taken in conjunction with a daily maintenance dose of aspirin 75 to 100 mg orally once a day.\n-For at least the first 12 months following ACS, this drug is superior to clopidogrel.\nUses:\n-To reduce the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction.\n-To reduce the rate of stent thrombosis in patients who have been stented for treatment of ACS.\nUsual Adult Dose for Thromboembolic Stroke Prophylaxis:\n60 mg orally twice a day\nUse: To reduce the risk of a first myocardial infarction (MI) or stroke in patients with coronary artery disease (CAD) at high risk for such events; while use is not limited to this setting, efficacy of this drug was established in a population with type 2 diabetes mellitus (T2DM).\nUsual Adult Dose for Coronary Artery Disease:\n60 mg orally twice a day\nUse: To reduce the risk of a first myocardial infarction (MI) or stroke in patients with coronary artery disease (CAD) at high risk for such events; while use is not limited to this setting, efficacy of this drug was established in a population with type 2 diabetes mellitus (T2DM).\nUsual Adult Dose for Myocardial Infarction -- Prophylaxis:\n60 mg orally twice a day\nUse: To reduce the risk of a first myocardial infarction (MI) or stroke in patients with coronary artery disease (CAD) at high risk for such events; while use is not limited to this setting, efficacy of this drug was established in a population with type 2 diabetes mellitus (T2DM).\n Detailed Brilinta dosage information\nWhat happens if I miss a dose?\nSkip the missed dose and use your next dose at the regular time. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nTell your doctor about all your current medicines. Many drugs can interact with Brilinta, especially:\nantifungal medicine (including ketoconazole, itraconozole, voriconazole, and others);\nantibiotic medication (including clarithromycin);\nantiviral medicine to treat HIV or AIDS;\nother blood thinners;\ncholesterol medication (including simvastatin or lovastatin);\nheart or blood pressure medication;\nopioid medication;\nseizure medicine; or\ntuberculosis medicine (especially rifampin).\nThis list is not complete and many other drugs may affect Brilinta. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Brilinta drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Brilinta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nchest pain;\nfainting or dizzy spells;\nnosebleeds, or any bleeding that will not stop;\nshortness of breath even with mild exertion or while lying down;\neasy bruising, unusual bleeding, purple or red spots under your skin;\nred, pink, or brown urine;\nblack, bloody, or tarry stools; or\ncoughing up blood or vomit that looks like coffee grounds.\nCommon Brilinta side effects may include:\nbleeding; or\nshortness of breath.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Brilinta side effects (more detail)\n','Brilinta (ticagrelor) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.\nBrilinta is used to lower your risk of heart attack, stroke, or death due to a blocked artery or a prior heart attack.\nBrilinta is also used to lower your risk of blood clots if you have coronary artery disease (decreased blood flow to the heart) and have been treated with stents to open clogged arteries.\nBrilinta is also used to lower your risk of a first heart attack or stroke if you have decreased blood flow to the heart.\nBrilinta is also used to lower the risk of stroke and death in adults with a blockage or decreased blood flow in an artery that supplies blood to the brain.\nThis medicine is usually given together with low-dose aspirin. Carefully follow your doctor\'s dosing instructions. Using too much aspirin can make ticagrelor less effective.\n','You should not use Brilinta if you have any active bleeding (including a bleeding stomach ulcer), or a history of bleeding in the brain. Do not use this medicine just before heart bypass surgery (coronary artery bypass graft, or CABG).\nYou may need to stop using this medicine for a short time before having surgery or dental work, to prevent excessive bleeding. Do not stop taking Brilinta without first talking to your doctor, even if you have signs of bleeding. Stopping this medicine may increase your risk of a heart attack or stroke.\nBrilinta may cause you to bleed more easily, which can be severe or life-threatening. Avoid activities that may increase your risk of bleeding or injury.\nCall your doctor or seek emergency medical attention if you have bleeding that will not stop. You may also have bleeding on the inside of your body, such as in your stomach or intestines. Call your doctor at once if you have black or bloody stools, red or pink urine, or if you cough up blood or vomit that looks like coffee grounds. These could be signs of internal bleeding.\nMany drugs (including some over-the-counter medicines and herbal products) can cause serious medical problems if you take them with Brilinta. It is very important to tell your doctor about all medicines you have recently used.\nBefore taking this medicine\nYou should not use Brilinta if you are allergic to ticagrelor, or if you have:\nany active bleeding; or\na history of bleeding in the brain (such as from a head injury).\nTell your doctor if you have ever had:\na stroke;\nheart problems;\nhigh cholesterol;\nbleeding problems;\na stomach ulcer or colon polyps;\nliver disease; or\nkidney disease;\nasthma, COPD (chronic obstructive pulmonary disorder) or other breathing problems;\nrecent surgery or serious injuries; or\nif you are planning to have surgery or a dental procedure; or\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether Brilinta passes into breastmilk. Talk to your doctor before using Brilinta if you are breastfeeding.\nHow should I take Brilinta?\nTake Brilinta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Brilinta is taken together with aspirin. Use these medicines exactly as directed.\nDo not take more aspirin than your doctor has prescribed. Taking too much aspirin can make Brilinta less effective.\nTake this medicine at the same time each day, with or without food.\nIf you cannot swallow a tablet whole, crush the pill and mix it with water. Stir and drink this mixture right away. Add more water to the glass, stir, and drink right away.\nBrilinta keeps your blood from coagulating (clotting) and can make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.\nTo prevent excessive bleeding, you may need to stop using Brilinta for a short time before a surgery, medical procedure, or dental work. Any healthcare provider who treats you should know that you are taking ticagrelor.\nDo not stop taking Brilinta without first talking to your doctor, even if you have signs of bleeding. Stopping the medicine could increase your risk of a heart attack or stroke.\nTicagrelor may affect medical testing for platelets in your blood and you may have false results. Tell the laboratory staff that you use Brilinta.\nStore at room temperature away from moisture and heat.\n','Drinking alcohol while taking aspirin can increase your risk of stomach bleeding.\nAvoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.\nWhile taking Brilinta with aspirin, avoid using medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to aspirin (such as salicylates, ibuprofen, ketoprofen, or naproxen). Taking certain products together can cause you to get too much aspirin which can increase your risk of bleeding.\n'),(105,'brukinsa','Usual Adult Dose for Lymphoma:\n160 mg orally 2 times a day until disease progression or unacceptable toxicity\nOR\n320 mg orally once a day until disease progression or unacceptable toxicity\nUse: For the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy\n Detailed Brukinsa dosage information\nWhat happens if I miss a dose?\nTake the missed dose on the same day you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not use 2 doses in one day.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may interact with zanubrutinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Brukinsa drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Brukinsa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nZanubrutinib can cause serious or life-threatening side effects. Call your doctor at once if you have:\npounding heartbeats or fluttering in your chest;\nchest discomfort;\na light-headed feeling, like you might pass out;\nliver problems - right-sided upper stomach pain, vomiting, loss of appetite, yellowing of your skin or eyes, and not feeling well;\nlow platelets in your blood - easy bruising, unusual bleeding, purple or red spots under your skin;\nlow red blood cells - pale skin, weakness, unusual tiredness, feeling light-headed or short of breath, cold hands and feet, fast or irregular heartbeat;\nlow white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing;\nsigns of bleeding inside your body - red or pink urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, severe headache, vision problems, numbness or weakness on one side, trouble speaking or understanding what is said to you; or\nsigns of infection - fever, chills, redness or swelling, cough with mucus, feeling short of breath.\nYour cancer treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon Brukinsa side effects may include:\ndiarrhea;\nlow platelet or other blood cell counts;\neasy bruising or bleeding;\nrash; or\ncold symptoms such as stuffy nose, sneezing, sore throat or cough.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Brukinsa side effects (more detail)\n','Brukinsa (zanubrutinib) is used to treat mantle cell lymphoma in adults who have received at least one prior treatment for this condition.\nBrukinsa was approved by the US Food and Drug Administration (FDA) on an \"accelerated\" basis. In clinical studies, some people responded to this medicine, but further studies are needed.\nIt is not known if Brukinsa is safe and effective in children.\n','Using Brukinsa may increase your risk of developing other cancers, such as skin cancer. Ask your doctor about this risk and what skin symptoms to watch for. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.\nTell your doctor if you have ever had liver disease.\nYou may need to have a negative pregnancy test before you start using Brukinsa.\nBefore taking this medicine\nBefore you start treatment with Brukinsa, tell your healthcare provider about all of your medical conditions, including if you:\nhave bleeding problems.\nhave had recent surgery or plan to have surgery. Your healthcare provider may stop Brukinsa for any planned medical, surgical, or dental procedure.\nhave an infection.\nhave or had heart rhythm problems.\nhave high blood pressure.\nhave liver problems, including a history of hepatitis B virus (HBV) infection.\nare pregnant or plan to become pregnant. Zanubrutinib can harm your unborn baby. If you are able to become pregnant, your healthcare provider may do a pregnancy test before starting treatment with this medicine.\nFemales should not become pregnant during treatment and for at least 1 week after the last dose. You should use effective birth control (contraception) during treatment and for at least 1 week after the last dose.\nMales should avoid getting female partners pregnant during treatment and for at least 1 week after the last dose of Brukinsa. You should use effective birth control (contraception) during treatment and for at least 1 week after the last dose.\nare breastfeeding or plan to breastfeed. It is not known if zanubrutinib passes into your breast milk. Do not breastfeed during treatment with Brukinsa and for at least 2 weeks after your last dose.\nTell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Brukinsa with certain other medications may affect how zanubrutinib works and can cause side effects.\nHow should I take Brukinsa?\nTake Brukinsa exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nTake this medicine with a full glass of water.\nYou may take Brukinsa with or without food.\nSwallow the capsule whole and do not crush, chew, break, or open it.\nBrukinsa affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.\nStore at room temperature away from moisture and heat.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(106,'bryhali','Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nDo not take by mouth. Topical medicine is for use only on the skin. Do not use on open wounds or on sunburned, windburned, dry, or irritated skin. Rinse with water if this medicine gets in your eyes or mouth.\nWash your hands before and after using halobetasol, unless you are using this medicine to treat the skin on your hands.\nShake the foam before each use.\nApply a thin layer of halobetasol topical to the affected skin and rub it in gently. Do not apply this medicine over a large area of skin unless your doctor has told you to.\nDo not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Covering treated areas can increase the amount of medicine absorbed through your skin and may cause harmful effects.\nIf you are treating the diaper area, do not use plastic pants or tight-fitting diapers.\nThis medicine is for short-term use only (2 weeks, or up to 8 weeks for psoriasis). Follow your doctor\'s dosing instructions very carefully.\nIf you use halobetasol to treat plaque psoriasis, you should stop using the medicine once your skin symptoms are controlled.\nYou may need medical tests to be sure this medicine is not causing harmful effects.\nCall your doctor if your symptoms do not improve, or if they get worse.\nYou should not stop using halobetasol suddenly. Follow your doctor\'s instructions about tapering your dose.\nStore at room temperature away from moisture and heat. Do not freeze.\nKeep Bryhali foam away from open flame or high heat. The canister may explode if it gets too hot. Do not puncture or burn an empty canister.\n Detailed Bryhali dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nApply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\nHigh doses or long-term use of  Bryhali can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.\n','Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.\n Bryhali drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nworsening of your skin condition;\nredness, warmth, swelling, oozing, or severe irritation of any treated skin;\nblurred vision, tunnel vision, eye pain, or seeing halos around lights;\nhigh blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or\npossible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.\nCommon side effects may include:\nburning, stinging, itching, or dryness of treated skin;\npain where the foam was applied;\nredness or crusting around your hair follicles;\nstretch marks;\nspider veins;\nheadache; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bryhali side effects (more detail)\n','Halobetasol is a highly potent steroid that helps reduce inflammation in the body.\nBryhali (for the skin) is used to treat inflammation and itching caused by plaque psoriasis or skin conditions that respond to steroid medication.\nBryhali may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use halobetasol if you are allergic to it.\nTell your doctor if you have ever had:\nany type of skin infection;\na skin reaction to any steroid medicine;\nan adrenal gland disorder;\nliver disease; or\nif you plan to have surgery.\nSteroid medicines can increase the glucose (sugar) levels in your blood or urine. Tell your doctor if you have diabetes.\nIt is not known whether  Bryhali will harm an unborn baby. Tell your doctor if you are pregnant.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. If you apply halobetasol to your chest, avoid areas that may come into contact with the baby\'s mouth.\nBryhali is not approved for use by anyone younger than 12 years old. Some brands or forms of this medicine are for use only in adults 18 and over.\nChildren can absorb larger amounts of this medicine through the skin and may be more likely to have side effects.\n','Avoid applying  Bryhali to your face, scalp, underarms, or groin area.\nDo not use Bryhali to treat any skin condition that has not been checked by your doctor.\nAvoid using other topical steroid medications on the areas you treat with halobetasol unless your doctor tells you to.\n'),(107,'budesonide','Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.\nTake this medicine in the morning with a full glass of water.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nSwallow the tablet or capsule whole and do not crush, chew, break, or open it.\nIf you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away, or within 30 minutes after mixing. Then drink a full glass of water.\nYour dosage needs may change if you have surgery, are ill, or are under stress. Do not change your doses or medication schedule without advice from your doctor.\nCall your doctor if your symptoms do not improve, or if they get worse while using budesonide.\nBudesonide can weaken your immune system. Tell your doctor if you have signs of infection such as fever, chills, body aches, vomiting, or feeling tired.\nIf you use this medicine long-term, you may need frequent medical tests.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\n Detailed Budesonide dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nHigh doses or long-term use of steroid medicine can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.\n','Many drugs can affect budesonide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Budesonide drug interactions (more detail)\nDoes Budesonide interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nthinning skin, easy bruising, increased acne or facial hair;\nswelling in your ankles;\nweakness, tiredness, or a light-headed feeling, like you might pass out;\nnausea, vomiting, rectal bleeding;\npain or burning when you urinate;\nmenstrual problems (in women), impotence or loss of interest in sex (in men); or\nsigns of too much steroid medicine in your blood--acne, bruising, thinning skin, increased facial or body hair, stretch marks, increased body fat, or changes in the shape or location of body fat (especially in your face, neck, back, and waist).\nCommon side effects may include:\nheadache, dizziness;\nindigestion, nausea, vomiting, stomach pain, bloating, gas, constipation;\nfeeling tired;\nback pain, joint pain;\npainful urination;\ncold symptoms such as stuffy nose, sneezing, sore throat;\npain anywhere in your body; or\nsigns of too much steroid medicine in your blood.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Budesonide side effects (more detail)\n','Budesonide is a steroid that reduces inflammation in the body.\nEntocort and Ortikos are used to treat mild to moderate Crohn\'s disease in adults and children at least 8 years old. These medicines are also used in adults to keep symptoms from returning for up to 3 months.\nUceris is used to treat mild to moderate ulcerative colitis (UC) in adults.\nBudesonide may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use budesonide if you are allergic to it.\nTell your doctor if you have ever had:\ntuberculosis;\nan infection, including chickenpox or measles;\nhigh blood pressure;\na weak immune system (caused by disease or by using certain medicines);\nosteoporosis or low bone mineral density;\na stomach ulcer;\nliver disease;\neczema;\nany allergy; or\n(in you or a family member) diabetes, cataracts, or glaucoma.\nTell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether budesonide will harm an unborn baby. However, having untreated or uncontrolled UC during pregnancy can cause complications leading to preterm delivery or low birth weight. The benefit of treating UC may outweigh any risks to the baby.\nIf you have taken budesonide during pregnancy, tell your doctor if you notice weakness, irritability, vomiting, or feeding problems in your newborn baby.\nYou should not breastfeed while using  budesonide.\nEntocort or Ortikos should not be given to a child younger than 8 years old or weighing less than 55 pounds (25 kilograms). Uceris is not approved for use by anyone younger than 18 years old.\nDo not use budesonide in a child to treat any condition that has not been checked by your doctor.\n','Grapefruit may interact with budesonide and lead to unwanted side effects. Avoid the use of grapefruit products.\nAvoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using budesonide.\n'),(108,'budesonide-and-formoterol','Note: If chronic obstructive pulmonary disease symptoms occur in the period between doses, an inhaled, short-acting beta-2 agonist (SABA) should be taken for immediate relief. For acute asthma exacerbations, budesonide/formoterol is preferred as a reliever; however, SABAs may be used. In patients presenting to primary care or acute care facility, SABAs are recommended for the acute management of exacerbations. For both Step 1 and Step 2 mild asthma, budesonide/formoterol may be used on an as-needed basis for control of asthma symptoms. Alternatively, a SABA as needed and daily use of low-dose inhaled glucocorticoid for Step 2 mild asthma may be used. Both options appear equally effective in reducing the frequency and severity of exacerbations in Step 2 mild asthma, but symptom control is somewhat better with daily inhaled glucocorticoids (Busse 2008; GINA 2020). The maximum dose is based on the formoterol component; to increase the dose of the inhaled glucocorticoid component, a separate inhaler with a higher budesonide dose per inhalation must be prescribed.\nAsthma (controller/maintenance): Oral inhalation:\nStarting dose is based on asthma severity.\nMetered-dose inhaler:\nBudesonide 80 mcg/formoterol 4.5 mcg: 2 inhalations once or twice daily (GINA 2020; Rabe 2006); if response is inadequate, may increase to higher dose combination after 1 to 2 weeks; maximum dose: Budesonide 160 mcg/formoterol 4.5 mcg: 2 inhalations twice daily.\nBudesonide 160 mcg/formoterol 4.5 mcg: 2 inhalations twice daily (Patel 2013)\nDry powder inhaler [Canadian product]:\nModerate to severe asthma, inhaler used as maintenance therapy only: \nSymbicort 100 Turbuhaler, Symbicort 200 Turbuhaler: 1 to 2 inhalations once or twice daily until symptom control, then titrate to lowest effective dosage to maintain control. Maximum recommended maintenance dose: 4 inhalations/day. During periods of worsening asthma, the dose may temporarily be increased up to a maximum of 8 inhalations/day.\nSymbicort Forte Turbuhaler: 1 inhalation once or twice daily until symptom control, then titrate to lowest effective dosage to maintain control. Maximum dose: 4 inhalations/day.\nModerate to severe asthma, maintenance therapy (as part of a combined maintenance/reliever protocol using the same inhaler): Symbicort 100 Turbuhaler or Symbicort 200 Turbuhaler: 1 to 2 inhalations twice daily or 2 inhalations once daily.\nAsthma (reliever for acute exacerbations): Oral inhalation: Note: Based on asthma severity, this regimen can be reliever only or maintenance PLUS reliever.\nMetered-dose inhaler (off-label use):\nBudesonide 80 mcg/formoterol 4.5 mcg or budesonide 160 mcg/formoterol 4.5 mcg: 1 inhalation as needed; may repeat if no relief (Bateman 2018; Beasley 2019; GINA 2020; O’Byrne 2018; Patel 2013; Rabe 2006). Maximum: Up to 12 inhalations/day (GINA 2020; Rabe 2006).\nDry powder inhaler [Canadian products]:\nMild persistent asthma, inhaler used as reliever therapy only: Symbicort 200 Turbuhaler: 1 inhalation as needed; may repeat if no relief after a few minutes, up to 6 inhalations per single occasion. Maximum daily dose: 8 inhalations/day.\nModerate to severe asthma, reliever therapy (as part of a combined maintenance/reliever protocol using the same inhaler): Symbicort 100 Turbuhaler or Symbicort 200 Turbuhaler: 1 inhalation as needed, may repeat if no relief for up to 6 inhalations per single occasion (maximum: 8 inhalations/day including maintenance therapy).\nChronic obstructive pulmonary disease: Oral inhalation:\nBudesonide 160 mcg/formoterol 4.5 mcg: Metered-dose inhaler: 2 inhalations twice daily (maximum: 2 inhalations twice daily).\nSymbicort 200 Turbuhaler [Canadian product]: Dry powder inhaler: 2 inhalations twice daily (maximum: 2 inhalations twice daily).\nSymbicort Forte Turbuhaler: [Canadian product]: Dry powder inhaler: 1 inhalation twice daily (maximum: 1 inhalation twice daily).\nDosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.\n Detailed Budesonide/formoterol dosage information\nDosing: Geriatric\nRefer to adult dosing.\nDosing: Pediatric\nAsthma; maintenance treatment:\nSymbicort: Metered-dose inhaler: Note: Do not administer more than 2 inhalations twice daily for maintenance treatment. The maximum maintenance dose is based on the formoterol component; to increase the dose of the inhaled glucocorticoid component, a separate inhaler with a higher budesonide dose per inhalation must be prescribed. If asthma symptoms occur in the period between doses, consider an inhaled, short-acting beta-2 agonist for immediate relief.\nChildren 5 to <12 years (limited data available for <6 years): Budesonide 80 mcg/formoterol 4.5 mcg: Oral inhalation: 2 inhalations twice daily (NAEPP 2007).\nChildren ≥12 years and Adolescents: Note: Initial dose prescribed should be based upon asthma severity and risk of exacerbation:\nBudesonide 80 mcg/formoterol 4.5 mcg: 2 inhalations twice daily. If adequate response is not seen after 1 to 2 weeks, consider the higher dose combination.\nBudesonide 160 mcg/formoterol 4.5 mcg: 2 inhalations twice daily.\nSymbicort 100 Turbuhaler, Symbicort 200 Turbuhaler [Canadian products]: Children ≥12 years and Adolescents: Dry powder inhaler: Oral inhalation:\nMaintenance therapy:\nInitial: 1 to 2 inhalations twice daily until symptom control, then titrate to lowest effective dosage to maintain control.\nMaintenance: 1 to 2 inhalations once or twice daily; may increase to 4 inhalations twice daily as temporary treatment in periods of worsening asthma; maximum daily dose: 8 inhalations/day.\nSymbicort Maintenance and Reliever Therapy (Symbicort SMART) [Canadian product]:\nMaintenance: 1 to 2 inhalations twice daily or 2 inhalations once daily.\nReliever therapy: 1 additional inhalation as needed, may repeat if no relief for up to 6 inhalations total; maximum daily dose: 8 inhalations/day.\nAsthma, acute exacerbation: Note: Based on asthma severity, this regimen is for use when patient is on budesonide/formoterol as maintenance to allow for a single inhaler for both maintenance PLUS reliever; the benefit seems to be greatest with very early signs of exacerbation (GINA 2018). GINA guideline and study dosing is based on the dry powder inhaler product (Turbuhaler); dry powder inhaler not available in US. Limited data available:\nChildren 4 to 11 years: Budesonide 80 mcg/formoterol 4.5 mcg: Dry powder inhaler: Oral inhalation:\nMaintenance: 1 inhalation once daily at bedtime (Bisgaard 2006; O\'Byrne 2005).\nReliever therapy: 1 inhalation as needed; may repeat if no relief; maximum daily dose: 8 inhalations/day (including maintenance dose) (Bisgaard 2006; O\'Byrne 2005).\nChildren ≥12 years and Adolescents: Budesonide 80 mcg/formoterol 4.5 mcg: Dry powder inhaler: Oral inhalation:\nMaintenance: 1 inhalation twice daily or 2 inhalations once daily at bedtime (O\'Byrne 2005; Rabe 2006).\nReliever therapy: 1 inhalation as needed; may repeat if no relief; maximum daily dose: 11 inhalations/day (including maintenance dose) (O\'Byrne 2018; Rabe 2006).\nDosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.\nAdministration\nMetered-dose inhaler: For oral inhalation only administered every morning and evening, approximately 12 hours apart. Prior to first use, inhaler must be primed by releasing 2 test sprays into the air; shake well for 5 seconds before each spray. Inhaler must be reprimed if not used for >7 days or if it has been dropped. Shake well for 5 seconds before each use. Discard inhaler after the labeled number of inhalations have been used or within 3 months after removal from foil pouch. Rinse mouth with water (spit out without swallowing) after each use. Do not wash inhaler with water; clean mouthpiece using a dry wipe every 7 days.\nDelivery of dose: Instruct patient to place mouthpiece gently between teeth, closing lips around inhaler. Instruct patient to inhale deeply, press the top counter, and hold breath for up to 10 seconds or as long as they comfortably can. Remove mouthpiece from mouth prior to exhalation. Patient should not breathe out through the mouthpiece. Wait ≥30 seconds prior to the second inhalation dose.\nDry powder inhaler: Symbicort Turbuhaler [Canadian product]:\nTo “load” inhaler: Turn red grip on inhaler as far as it will move in one direction, then turn in opposite direction as far as it will go (inhaler is “loaded” with a dose, indicated by a “click”). Prior to first use, this procedure should be done twice, it does not need to be repeated with subsequent uses even when not used regularly.\nDelivery of dose: Instruct patient to place mouthpiece gently between teeth, closing lips around inhaler. Instruct patient to inhale deeply and hold breath for as long as they comfortably can. Remove mouthpiece prior to exhalation. Patient should not breathe out through the mouthpiece. Dose is lost if patient drops, shakes, or exhales into inhaler after a dose has been loaded. After use of the inhaler, patient should rinse mouth/oropharynx with water and spit out rinse solution. Do not wash inhaler with water; clean mouthpiece using a dry wipe every 7 days.\n','Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin.  Avoid combination\nAtoMOXetine: May enhance the tachycardic effect of Beta2-Agonists. Monitor therapy\nAtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy\nAtosiban: Beta2-Agonists may enhance the adverse/toxic effect of Atosiban. Specifically, there may be an increased risk for pulmonary edema and/or dyspnea.  Monitor therapy\nBeta2-Agonists (Long-Acting): May enhance the adverse/toxic effect of other Beta2-Agonists (Long-Acting). Avoid combination\nBeta-Blockers (Beta1 Selective): May diminish the bronchodilatory effect of Beta2-Agonists. Of particular concern with nonselective beta-blockers or higher doses of the beta1 selective beta-blockers. Monitor therapy\nBeta-Blockers (Nonselective): May diminish the bronchodilatory effect of Beta2-Agonists. Avoid combination\nBetahistine: May diminish the therapeutic effect of Beta2-Agonists. Monitor therapy\nCaffeine and Caffeine Containing Products: May enhance the adverse/toxic effect of Formoterol. Caffeine and Caffeine Containing Products may enhance the hypokalemic effect of Formoterol. Monitor therapy\nCannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Monitor therapy\nCocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Consider therapy modification\nCosyntropin: Corticosteroids (Orally Inhaled) may diminish the diagnostic effect of Cosyntropin.  Monitor therapy\nCYP3A4 Inhibitors (Moderate): May increase the serum concentration of Budesonide (Oral Inhalation). Monitor therapy\nCYP3A4 Inhibitors (Strong): May increase the serum concentration of Budesonide (Oral Inhalation). Monitor therapy\nDesmopressin: Corticosteroids (Orally Inhaled) may enhance the hyponatremic effect of Desmopressin.  Avoid combination\nDoxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline.  Monitor therapy\nGuanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Monitor therapy\nHaloperidol: QT-prolonging Agents (Indeterminate Risk - Caution) may enhance the QTc-prolonging effect of Haloperidol.  Monitor therapy\nInhalational Anesthetics: May enhance the arrhythmogenic effect of Formoterol. Monitor therapy\nLinezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid.  Specific dose adjustment recommendations are not presently available. Consider therapy modification\nLoop Diuretics: Beta2-Agonists may enhance the hypokalemic effect of Loop Diuretics.  Monitor therapy\nLoxapine: Agents to Treat Airway Disease may enhance the adverse/toxic effect of Loxapine. More specifically, the use of Agents to Treat Airway Disease is likely a marker of patients who are likely at a greater risk for experiencing significant bronchospasm from use of inhaled loxapine.  Management: This is specific to the Adasuve brand of loxapine, which is an inhaled formulation.  This does not apply to non-inhaled formulations of loxapine. Avoid combination\nMethacholine: Beta2-Agonists (Long-Acting) may diminish the therapeutic effect of Methacholine.  Management: Hold long-acting beta2 agonists for 36 hours before methacholine use. Consider therapy modification\nMonoamine Oxidase Inhibitors: May enhance the adverse/toxic effect of Beta2-Agonists. Monitor therapy\nOzanimod: May enhance the hypertensive effect of Sympathomimetics. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification\nQT-prolonging Agents (Highest Risk): QT-prolonging Agents (Indeterminate Risk - Caution) may enhance the QTc-prolonging effect of QT-prolonging Agents (Highest Risk).  Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Monitor therapy\nSolriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol.  Monitor therapy\nSympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy\nTedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy\nTheophylline Derivatives: May enhance the adverse/toxic effect of Formoterol. Theophylline Derivatives may enhance the hypokalemic effect of Formoterol. Monitor therapy\nThiazide and Thiazide-Like Diuretics: Beta2-Agonists may enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics.  Monitor therapy\nTobacco (Smoked): May diminish the therapeutic effect of Corticosteroids (Orally Inhaled). Monitor therapy\nTricyclic Antidepressants: May enhance the adverse/toxic effect of Beta2-Agonists. Monitor therapy\n Budesonide/formoterol drug interactions (more detail)\nAdverse Reactions\nThe following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Reported incidences are for adolescents and adults unless specified otherwise. Also see individual agents.\n>10%:\nCentral nervous system: Headache (7% to 11%; children: ≥3%)\nRespiratory: Nasopharyngitis (7% to 11%), upper respiratory tract infection (4% to 11%; children: ≥3%)\n1% to 10%:\nGastrointestinal: Abdominal distress (1% to 7%), oral candidiasis (1% to 6%), vomiting (1% to 3%)\nInfection: Influenza (2% to 3%)\nNeuromuscular & skeletal: Back pain (2% to 3%)\nRespiratory: Pharyngolaryngeal pain (6% to 9%), pulmonary infection (7% to 8%), lower respiratory tract infection (3% to 8%), sinusitis (4% to 6%), bronchitis (5%), nasal congestion (3%), pharyngitis (children: ≥3%), rhinitis (children: ≥3%)\n<1%, postmarketing, and/or case reports: Agitation, anaphylaxis, angina pectoris, angioedema, atrial arrhythmia, behavioral changes, bronchospasm, bruise, cataract, cough, decreased linear skeletal growth rate (pediatric patients), depression, dermatitis, dizziness, extrasystoles, glaucoma, hypercorticoidism signs and symptoms, hyperglycemia, hypersensitivity reaction, hypertension, hypokalemia, hypotension, immunosuppression, increased intraocular pressure, insomnia, muscle cramps, nausea, nervousness, palpitations, pruritus, restlessness, skin rash, tachycardia, throat irritation, tremor, urticaria, ventricular arrhythmia, voice disorder\n',NULL,'Asthma (controller/maintenance): Treatment of asthma in patients ≥6 years of age.\nChronic obstructive pulmonary disease: Maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema; to reduce COPD exacerbations.\nOff Label Uses\nAsthma (reliever for acute exacerbations)\nData from 2 randomized, double-blind, parallel group trials support the use of budesonide/formoterol (single combination inhaler) as quick relief on an as-needed basis for acute asthma exacerbations in outpatients with mild to mild to moderate asthma, and reduced overall corticosteroid exposure [Bateman 2018], [O’Byrne 2018]. In addition, data from 2 studies showed a reduction in the rate of severe asthma exacerbations when compared to use of an as-needed short-acting beta agonist [Beasley 2019], [O’Byrne 2018]. Data from 2 randomized, parallel group trials support the use of budesonide/formoterol single combination inhaler for use as maintenance and reliever therapy (SMART) and was shown to reduce the risk of severe asthma exacerbations and oral systemic corticoid exposure [Patel 2013], [Rabe 2006]. Data from a meta-analysis (15 clinical trials) also support the use of budesonide/formoterol as single maintenance and reliever therapy compared to standard therapy in patients with persistent asthma and was associated with a lower risk of asthma exacerbations [Sobieraj 2018].\nBased on the Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention guidelines, use of combination low dose budesonide/formoterol single inhaler in patients with asthma exacerbations may be used as both maintenance and reliever treatment and was shown to reduce exacerbations, including exacerbations requiring oral corticosteroids and hospitalizations [GINA 2020].\n','Concerns related to adverse effects:\n• Adrenal suppression: May cause hypercortisolism or suppression of hypothalamic-pituitary-adrenal (HPA) axis, particularly in younger children or in patients receiving high doses for prolonged periods. HPA axis suppression may lead to adrenal crisis. Withdrawal and discontinuation of a corticosteroid should be done slowly and carefully. Particular care is required when patients are transferred from systemic corticosteroids to inhaled products due to possible adrenal insufficiency or withdrawal from steroids, including an increase in allergic symptoms. Adult patients receiving >20 mg per day of prednisone (or equivalent) may be most susceptible. Fatalities have occurred due to adrenal insufficiency in asthmatic patients during and after transfer from systemic corticosteroids to aerosol steroids; aerosol steroids do not provide the systemic steroid needed to treat patients having trauma, surgery, or infections. Do not use this product to transfer patients from oral corticosteroid therapy.\n• Asthma-related deaths: The use of long-acting beta-2 agonists (LABAs) as monotherapy has been associated with an increased risk of severe exacerbations and asthma-related deaths (SMART 2006; Walters 2007); additional data from other clinical trials suggests risk of asthma-related hospitalization may also be increased with LABA monotherapy in pediatric and adolescent patients. However, data from large randomized, double-blind controlled trials do not show a significant increase in risk of serious asthma-related events (including hospitalizations, intubations, and death) in adults, adolescents, and pediatric patients (aged 4 to 11 years) when fixed-dose LABAs are used with inhaled corticosteroids combined in a single inhaler compared with inhaled corticosteroid monotherapy (FDA 2017). Current guidelines recommend the use of an as-needed low-dose inhaled corticosteroid with formoterol for patients with infrequent symptoms (GINA 2020). No data exist associating LABA use with an increased risk of death in patients with COPD.\n• Bone density: Long-term use of inhaled corticosteroids have been associated with decreases in bone mineral density. Use with caution in patients with major risk factors for decreased bone mineral count such as prolonged immobilization, family history of osteoporosis, postmenopausal status, tobacco use, advanced age, poor nutrition, or chronic use of drugs that can reduce bone mass (eg, anticonvulsants or oral corticosteroids); high doses and/or long-term use of inhaled corticosteroids have been associated with decreases in bone mineral density.\n• Bronchospasm: Rarely, paradoxical bronchospasm may occur with use of inhaled bronchodilating agents; this should be distinguished from inadequate response.\n• Hypersensitivity reactions: Immediate hypersensitivity reactions (urticaria, angioedema, rash, bronchospasm) have been reported.\n• Immunosuppression: Prolonged use of corticosteroids may increase the incidence of secondary infection, mask acute infection (including fungal infections), prolong or exacerbate viral infections, or limit response to vaccines. Avoid use if possible in patients with ocular herpes; active or quiescent tuberculosis infections of the respiratory tract; or untreated viral, fungal, or bacterial or parasitic systemic infections. Exposure to chickenpox or measles should be avoided; if the patient is exposed to chickenpox, prophylaxis with varicella zoster immune globulin or pooled intravenous immunoglobulin may be indicated; if chickenpox develops, treatment with antiviral agents may be considered. If exposure to measles, prophylaxis with pooled intramuscular immunoglobulin may be indicated.\n• Lower respiratory infections: Pneumonia and other lower respiratory tract infections have been reported in patients with COPD following the use of inhaled corticosteroids; monitor COPD patients closely since pneumonia symptoms may overlap symptoms of exacerbations.\n• Oral candidiasis: Local oropharyngeal Candida infections have been reported; if this occurs, treat appropriately while either continuing or interrupting (if necessary) budesonide/formoterol therapy.\n• Serious effects/fatalities: Do not exceed recommended dose; serious adverse events, including fatalities, have been associated with excessive use of inhaled sympathomimetics.\n• Vasculitis: Rare cases of vasculitis (eosinophilic granulomatosis with polyangiitis [formerly known as Churg-Strauss]) or other systemic eosinophilic conditions can occur; often associated with decrease and/or withdrawal of oral corticosteroid therapy following initiation of inhaled corticosteroid.\nDisease-related concerns:\n• Asthma: Appropriate use: For acute asthma exacerbations, budesonide/formoterol is preferred as a reliever; however, short-acting beta-2 agonists (SABAs) may be used. In patients presenting to primary care or acute care facility, SABAs are recommended for the acute management of exacerbations (GINA 2020).\n• Cardiovascular disease: Use with caution in patients with cardiovascular disease (arrhythmia, coronary insufficiency, or hypertension); beta agonists may cause elevation in blood pressure, heart rate and result in CNS stimulation/excitation. Beta-2 agonists may also increase risk of arrhythmias and ECG changes, such as flattening of the T-wave, prolongation of the QTc interval, and ST segment depression. Use with caution following acute MI; corticosteroids have been associated with myocardial rupture.\n• COPD: Appropriate use: Do not use for acute episodes of COPD. Do not initiate in patients with significantly worsening or acutely deteriorating COPD. Data are not available to determine if LABA use increases the risk of death in patients with COPD.\n• Diabetes: Use with caution in patients with diabetes mellitus; beta-2 agonists may increase serum glucose and aggravate preexisting diabetes mellitus and ketoacidosis.\n• Hepatic impairment: Use with caution in patients with hepatic impairment; may lead to accumulation of budesonide and formoterol; monitor closely.\n• Hypokalemia: Use with caution in patients with hypokalemia; beta-2 agonists may decrease serum potassium (transient).\n• Ocular disease: Use with caution in patients with cataracts and/or glaucoma; increased intraocular pressure, open-angle glaucoma, and cataracts have occurred with prolonged use of inhaled corticosteroids. Consider routine eye exams in chronic users.\n• Seizure disorders: Use with caution in patients with seizure disorders; beta agonists may result in CNS stimulation/excitation.\n• Thyroid disease: Changes in thyroid status may necessitate dosage adjustments; metabolic clearance of corticosteroids increases in hyperthyroid patients and decreases in hypothyroidism.\nSpecial populations:\n• Pediatric: LABAs when used as monotherapy, may increase the risk of asthma-related hospitalization in pediatric and adolescent patients. When LABAs are used in a fixed-dose combination with inhaled corticosteroids, data from large clinical trials in adolescents do not show a significant increase in the risk of serious asthma-related events (hospitalizations, intubations, death) compared to inhaled corticosteroids alone. Orally inhaled corticosteroids may cause a reduction in growth velocity in pediatric patients (~1 centimeter per year [range 0.3 to 1.8 cm per year] and related to dose and duration of exposure). To minimize the systemic effects of orally inhaled corticosteroids, each patient should be titrated to the lowest effective dose. Growth should be routinely monitored in pediatric patients.\nOther warnings/precautions:\n• Discontinuation of systemic corticosteroids: Withdraw systemic corticosteroid therapy with gradual tapering of dose; consider reducing the daily prednisone dose by 2.5 mg on a weekly basis beginning after at least 1 week of inhalation therapy. Monitor lung function, beta agonist use, asthma symptoms, and for signs and symptoms of adrenal insufficiency (fatigue, lassitude, weakness, nausea and vomiting, hypotension) during withdrawal.\nMonitoring Parameters\nFEV1, peak flow meter and/or other pulmonary function tests; monitor growth in pediatric patients, symptom relief, monitor for increased use if short-acting beta2-adrenergic agonists (may be a sign of asthma or COPD deterioration); HPA axis suppression; bone mineral density; blood pressure, heart rate; CNS stimulation; serum glucose, serum potassium\n',NULL),(109,'bumetanide','Dosing\nThe dose of bumetanide will be different for different patients. Follow your doctor\'s orders or the directions on the label. The following information includes only the average doses of bumetanide. If your dose is different, do not change it unless your doctor tells you to do so.\nThe amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.\nFor oral dosage form (tablets):\nFor edema:\nAdults—0.5 to 2 milligrams (mg) once a day. Your doctor may adjust your dose if needed.\nChildren—Use and dose must be determined by your doctor .\nMissed dose\nIf you miss a dose of bumetanide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.\nStorage\nStore the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.\nKeep out of the reach of children.\nDo not keep outdated medicine or medicine no longer needed.\nAsk your healthcare professional how you should dispose of any medicine you do not use.\n Detailed Bumetanide dosage information\n',NULL,'Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\nCheck with your doctor immediately if any of the following side effects occur:\nMore common\nAbdominal pain\nblurred vision\nconfusion\ndecreased urine output\ndizziness\ndrowsiness\ndry mouth\nfast or irregular heartbeat\nflushed, dry skin\nfruit-like breath odor\nheadache\nincreased hunger\nincreased thirst\nincreased urination\nirritability\njoint pain, stiffness, or swelling\nloss of appetite\nloss of mental alertness\nlower back, side, or stomach pain\nmood or mental changes\nmuscle pain or cramps\nnausea or vomiting\nnumbness or tingling in the hands, feet, or lips\nshortness of breath\nsweating\nswelling of face, hands, feet, ankles, or lower legs\ntroubled breathing\nunexplained weight loss\nunusual tiredness or weakness\nweak pulse\nRare\nAgitation\nback pain\nblack, tarry stools\nbleeding gums\nblood in the urine or stools\nchest pain\nconvulsions (seizures)\ndeep or fast breathing with dizziness\ndizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly\nfever\nhallucinations\nhives\nincrease in heart rate\nincreased blood pressure\nnumbness of feet, hands, and around the mouth\npinpoint red spots on the skin\nrapid breathing\nstiff neck\nsunken eyes\ntrembling, jerking of hands\nunusual bleeding or bruising\nweight gain\nwrinkled skin\nGet emergency help immediately if any of the following symptoms of overdose occur:\nSymptoms of overdose\nDifficulty breathing\npain in chest, groin, or legs, especially the calves\nsevere, sudden headache\nslurred speech\nsudden loss of coordination\nsudden, severe weakness or numbness in the arm or leg\nsudden, unexplained shortness of breath\nunusual drowsiness, dullness, or feeling of sluggishness\nvision changes\nSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:\nRare\nDecreased interest in sexual intercourse\ndiarrhea\ndifficulty with moving\near discomfort\nfeeling of constant movement of self or surroundings\ninability to have or keep an erection\nitching skin\nloss in sexual ability, desire, drive, or performance\nmuscle or bone pain\nmuscle stiffness\nnipple tenderness\npain, swelling, or redness in joints\nrash\nsensation of spinning\nshorter than usual time to ejaculation of semen\ntrouble with hearing\nupset stomach\nOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.\nCall your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.\n Bumetanide side effects (more detail)\n','Bumetanide belongs to a group of medicines called loop diuretics or \"water pills.\" Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .\nBumetanide is available only with your doctor\'s prescription .\n','It is very important that your doctor check your progress at regular visits to make sure bumetanide is working properly. Blood tests may be needed to check for unwanted effects .\nBumetanide may cause you to lose more potassium from your body than normal. Your doctor will monitor the potassium in your blood while you are taking bumetanide. To prevent the loss of too much water and potassium, tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea. Check with your doctor right away if you have one or more of these symptoms: dry mouth; increased thirst; muscle cramps; or nausea or vomiting .\nBumetanide can lower the number of platelets in your blood. Platelets are necessary for proper blood clotting. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin .\nBumetanide may cause changes in your blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .\n',NULL),(110,'bumex','Dosing\nThe dose of this medicine will be different for different patients. Follow your doctor\'s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.\nThe amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.\nFor oral dosage form (tablets):\nFor edema:\nAdults—0.5 to 2 milligrams (mg) once a day. Your doctor may adjust your dose if needed.\nChildren—Use and dose must be determined by your doctor .\nMissed dose\nIf you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.\nStorage\nStore the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.\nKeep out of the reach of children.\nDo not keep outdated medicine or medicine no longer needed.\nAsk your healthcare professional how you should dispose of any medicine you do not use.\n Detailed Bumex dosage information\n',NULL,'Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\nCheck with your doctor immediately if any of the following side effects occur:\nMore common\nAbdominal pain\nblurred vision\nconfusion\ndecreased urine output\ndizziness\ndrowsiness\ndry mouth\nfast or irregular heartbeat\nflushed, dry skin\nfruit-like breath odor\nheadache\nincreased hunger\nincreased thirst\nincreased urination\nirritability\njoint pain, stiffness, or swelling\nloss of appetite\nloss of mental alertness\nlower back, side, or stomach pain\nmood or mental changes\nmuscle pain or cramps\nnausea or vomiting\nnumbness or tingling in the hands, feet, or lips\nshortness of breath\nsweating\nswelling of face, hands, feet, ankles, or lower legs\ntroubled breathing\nunexplained weight loss\nunusual tiredness or weakness\nweak pulse\nRare\nAgitation\nback pain\nblack, tarry stools\nbleeding gums\nblood in the urine or stools\nchest pain\nconvulsions (seizures)\ndeep or fast breathing with dizziness\ndizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly\nfever\nhallucinations\nhives\nincrease in heart rate\nincreased blood pressure\nnumbness of feet, hands, and around the mouth\npinpoint red spots on the skin\nrapid breathing\nstiff neck\nsunken eyes\ntrembling, jerking of hands\nunusual bleeding or bruising\nweight gain\nwrinkled skin\nGet emergency help immediately if any of the following symptoms of overdose occur:\nSymptoms of overdose\nDifficulty breathing\npain in chest, groin, or legs, especially the calves\nsevere, sudden headache\nslurred speech\nsudden loss of coordination\nsudden, severe weakness or numbness in the arm or leg\nsudden, unexplained shortness of breath\nunusual drowsiness, dullness, or feeling of sluggishness\nvision changes\nSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:\nRare\nDecreased interest in sexual intercourse\ndiarrhea\ndifficulty with moving\near discomfort\nfeeling of constant movement of self or surroundings\ninability to have or keep an erection\nitching skin\nloss in sexual ability, desire, drive, or performance\nmuscle or bone pain\nmuscle stiffness\nnipple tenderness\npain, swelling, or redness in joints\nrash\nsensation of spinning\nshorter than usual time to ejaculation of semen\ntrouble with hearing\nupset stomach\nOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.\nCall your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.\n Bumex side effects (more detail)\n','Bumetanide belongs to a group of medicines called loop diuretics or \"water pills.\" Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .\nThis medicine is available only with your doctor\'s prescription .\n','It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects .\nThis medicine may cause you to lose more potassium from your body than normal. Your doctor will monitor the potassium in your blood while you are taking this medicine. To prevent the loss of too much water and potassium, tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea. Check with your doctor right away if you have one or more of these symptoms: dry mouth; increased thirst; muscle cramps; or nausea or vomiting .\nBumetanide can lower the number of platelets in your blood. Platelets are necessary for proper blood clotting. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin .\nThis medicine may cause changes in your blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .\n',NULL),(111,'buprenex','Usual Adult Dose for Pain:\nInitial dose: 0.3 mg deep IM or slow IV (over at least 2 minutes); may repeat this dose once after 30 to 60 minutes if needed; then, 0.3 mg IV/IM every 6 hours as needed\n-A single 0.6 mg IM dose may be given to patients who are not in a high risk category (see Warnings)\nMaximum single dose: 0.3 mg (IV) or 0.6 mg (IM)\nUsual Pediatric Dose for Pain:\n2 to 12 years:\nInitial dose: 2 to 6 mcg/kg IM or slow IV every 4 to 6 hours\n-Some patients may not need to be remedicated for 6 to 8 hours; fixed interval or round the clock dosing should not be used until the proper inter-dose interval has been established\nOver 12 years:\nInitial dose: 0.3 mg deep IM or slow IV (over at least 2 minutes); may repeat this dose once after 30 to 60 minutes if needed; then, 0.3 mg IV/IM every 6 hours as needed\nMaximum single dose: 0.3 mg\nComments:\n-Use extra caution with IV administration, especially the first dose.\n-Monitor closely for respiratory depression, especially within the first 24 to 72 hours.\n-Use the lowest effective dose for the shortest duration consistent with the individual patient\'s treatment goals.\nUse: For the management of pain severe enough to require an opioid analgesic and for which alternate treatments are inadequate.\n Detailed Buprenex dosage information\nWhat happens if I miss a dose?\nBecause you will receive Buprenex in a clinical setting, you are not likely to miss a dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Buprenex can be fatal, especially in a person using the medicine without a prescription. Overdose symptoms may include extreme drowsiness or weakness, cold or clammy skin, slow heart rate, weak pulse, very slow breathing, or coma.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nOpioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother narcotic medications - opioid pain medicine or prescription cough medicine;\na sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;\ndrugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness;\ndrugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete. Other drugs may interact with buprenorphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Buprenex drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Buprenex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nnoisy breathing, sighing, shallow breathing, breathing that stops during sleep;\nslow heartbeat or weak pulse;\nblue lips or fingernails;\nsevere constipation;\nconfusion, feelings of extreme happiness;\nlittle or no urination; or\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.\nSeek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.\nSerious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.\nLong-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.\nCommon Buprenex side effects may include:\ndrowsiness;\nconstipation;\ndizziness, spinning sensation;\nnausea, vomiting;\nincreased sweating;\nheadache; or\nblurred vision, double vision.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Buprenex side effects (more detail)\n','Buprenex (buprenorphine) is an opioid medicine used to treat pain. An opioid is sometimes called a narcotic.\nBuprenex Injection is used to relieve moderate pain that is severe enough to require an opiate pain killer and for which other medicines (e.g., non-opiate pain killers or opiate-containing combination medicines) have not been, or are not expected to be sufficient.\nThis medication guide provides information about the Buprenex brand of buprenorphine injection. Sublocade is another brand of buprenorphine injection used to treat opioid addiction.\n','MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.\nUsing Buprenex during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore taking this medicine\nYou should not use Buprenex if you are allergic to buprenorphine, or if you have:\nsevere asthma or breathing problems; or\na blockage in your stomach or intestines.\nTo make sure Buprenex is safe for you, tell your doctor if you have ever had:\nbreathing problems, sleep apnea;\na head injury, brain tumor, or seizures;\nalcoholism, drug addiction, mental illness;\nurination problems;\nliver or kidney disease;\na heart rhythm disorder (especially if you take medication to treat it);\nlong QT syndrome (in you or a family member);\nan electrolyte imbalance (such as low levels of potassium or magnesium in your blood);\nabnormal curvature of the spine that affects breathing;\nAddison\'s disease (adrenal gland disorder); or\nproblems with your gallbladder, pancreas, or thyroid.\nIf you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.\nBuprenorphine can pass into breast milk and may harm a nursing baby. Do not breast-feed while you are using Buprenex.\nHow should I use Buprenex?\nBuprenex is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection. Buprenex is usually given by injection only if you are unable to take the medicine by mouth or use another form of buprenorphine.\nBuprenex is usually given at evenly spaced intervals, up to 6 hours apart. Tell your doctor if Buprenex does not relieve your pain within 1 hour after an injection.\nBuprenex can cause irritation if it gets on your skin. If this occurs, remove any clothing the medicine has spilled onto, and rinse your skin with water.\nNever share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or hazardous activity until you know how Buprenex will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(112,'buprenorphine','Use buprenorphine exactly as it was prescribed for you. Follow the directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Never use buprenorphine in larger amounts, or for longer than prescribed.\nBuprenorphine sublingual is usually taken for only at the start of treatment for addiction. Most people are later switched to another medicine that contains buprenorphine (Bunavail, Sublocade, Suboxone, Zubsolv).\nYou may receive your first doses of buprenorphine sublingual in a hospital or clinic setting until your condition improves.\nNever share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.\nUse dry hands when handling the tablet. Place the tablet under your tongue and allow it to dissolve with your mouth closed. Do not chew the tablet or swallow it whole.\nIf your doctor has prescribed more than 2 tablets per dose, place the correct number of tablets under your tongue at the same time and allow them to dissolve completely.\nDo not eat or drink anything until the tablet or film has completely dissolved in your mouth.\nYou may need frequent blood tests to check your liver function.\nIf you need surgery, tell the surgeon ahead of time that you are using buprenorphine.\nNever crush or break a buprenorphine pill to inhale the powder or mix it into a liquid to inject the drug into your vein. Doing so could result in death.\nAny medical care provider who treats you should know that you are being treated for opioid addiction, and that you are taking buprenorphine sublingual. Make sure your family members know how to provide this information in case they need to speak for you during an emergency.\nDo not stop using buprenorphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.\nStore at room temperature away from moisture and heat. Keep track of your medicine. Buprenorphine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\nDo not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.\n Detailed Buprenorphine dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. A buprenorphine overdose can be fatal, especially in a child or other person using the medicine without a prescription.\nOverdose symptoms may include extreme drowsiness or weakness, cold or clammy skin, pinpoint pupils, slow heart rate, weak pulse, very slow breathing, or coma.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nBuprenorphine can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother narcotic medications - opioid pain medicine or prescription cough medicine;\na sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;\ndrugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or\ndrugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete. Other drugs may interact with buprenorphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Buprenorphine drug interactions (more detail)\nAlternatives to buprenorphine\nBuprenorphine is available in different dosage forms and there are other alternative drugs used to treat opioid use disorder or severe pain. Talk with your healthcare provider which option would be best suited to you\nMedicines used to treat opioid addiction:\nBuprenorphine:\nSubcutaneous injection, abdominal (Sublocade);\nImplant (Probuphine);\nSublingual tablets (Subutex).\nBuprenorphine and naloxone\nSublingual film (Bunavail);\nSublingual film and sublingual tablets (Suboxone);\nSublingual tablets (Zubsolv).\nLofexidine\nTablets (Lucemyra).\nNaltrexone\nIM injection (Vivitrol);\nTablets (Naltrexone).\nFor opioid overdose in an emergency situation:\nNaloxone\nNasal spray (Narcan, Kloxxado);\nNaloxone injection.\nMedicines used to treat severe pain:\nBuprenorphine:\nIM and IV injection (Buprenex);\nBuccal film (Belbuca);\nTransdermal patch (Butrans).\nThere are other groups of pain relieving medicines (including narcotic analgesics).\nMedicine to treat opioid addiction or moderate to severe pain:\nMethadone\nTablets (Dolophine).\n','Get emergency medical help if you have signs of an allergic reaction to buprenorphine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once if you have:\nopioid withdrawal symptoms - shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain;\nnoisy breathing, sighing, shallow breathing, breathing that stops during sleep;\nslow heartbeat or weak pulse;\na light-headed feeling, like you might pass out;\nchest pain, trouble breathing;\nlow cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or\nliver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).\nSeek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.\nCommon buprenorphine side effects may be more likely to occur, such as:\nconstipation, nausea, vomiting;\nheadache;\nincreased sweating;\nsleep problems (insomnia); or\npain anywhere in your body.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Buprenorphine side effects (more detail)\n','Buprenorphine is an opioid medication.\nBuprenorphine sublingual tablets (given under the tongue) are a prescription medicine used to treat opioid addiction (either prescription or illegal drugs), as part of a complete treatment program that also includes counseling and behavioral therapy.\nBuprenorphine sublingual tablets are most often used for the first 1 or 2 days to help you start with treatment.\nOther forms of buprenorphine are used to treat moderate to severe pain.\n','Buprenorphine sublingual tablets are not for use as a pain medication.\nMISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep buprenorphine in a place where others cannot get to it.\nTaking buprenorphine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use buprenorphine with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to buprenorphine, or:\nif you have used another narcotic drug within the past 4 hours.\nTo make sure buprenorphine is safe for you, tell your doctor if you have ever had:\nmethadone treatment;\nbreathing problems, sleep apnea;\nabnormal curvature of the spine that affects breathing;\nliver disease (especially hepatitis B or C);\nkidney disease;\nenlarged prostate, urination problems;\na head injury or brain tumor;\nalcoholism, hallucinations, mental illness; or\nproblems with your stomach, gallbladder, adrenal gland, or thyroid.\nIf you use buprenorphine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.\nBuprenorphine can pass into breast milk and may cause drowsiness, and breathing problems in a nursing baby. Ask your doctor about any risk.\nBuprenorphine is not approved for use by anyone younger than 18 years old.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or operating machinery until you know how buprenorphine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\n'),(113,'buprenorphine-and-naloxone','Opioid use disorder: Note:  Prior to induction, consider type of opioid use (ie, long- or short-acting opioid) and time since last use of opioid. \nPatients on heroin or short-acting prescription opioids should initiate buprenorphine/naloxone when signs of opioid withdrawal occur, but no sooner than 6 hours after the last use of heroin or other short-acting opioid (SAMHSA 2018; manufacturer’s labeling).\nPatients on methadone should have their methadone maintenance dose reduced to the minimum tolerable dose and remain on that dose for ≥7 days; initiate buprenorphine/naloxone only when early signs of withdrawal appear but no sooner than 24 hours after the last methadone dose. Waiting ≥36 hours after last use of methadone and initiating at lower doses (eg, buprenorphine 2 mg/naloxone 0.5 mg) decreases risk of precipitated methadone withdrawal (SAMHSA 2018). Despite the manufacturer’s recommendation to use buprenorphine instead of buprenorphine/naloxone during the induction period for long-acting opioid dependence due to the risk of withdrawal caused by naloxone, some experts recommend the combination product or buprenorphine for induction for long- and short-acting opioids (SAMHSA 2018).\nUS labeling:\n Induction:\nNote:\nTitrate induction dose carefully to control acute withdrawal symptoms while avoiding sedation and monitoring for onset of precipitated withdrawal symptoms (SAMHSA 2018).\nBuccal film (Bunavail: Buprenorphine 2.1 mg/naloxone 0.3 mg; buprenorphine 4.2 mg/naloxone 0.7 mg; buprenorphine 6.3 mg/naloxone 1 mg):\nDay 1 induction dose: Initial: Buccal: Buprenorphine 2.1 mg/naloxone 0.3 mg; may repeat dose after ~2 hours, based on control of acute withdrawal symptoms; maximum total dose: buprenorphine 4.2 mg/naloxone 0.7 mg.\nDay 2 induction dose: Up to buprenorphine 8.4 mg/naloxone 1.4 mg as a single dose.\nSublingual film (Suboxone: Buprenorphine 2 mg/naloxone 0.5 mg; buprenorphine 4 mg/naloxone 1 mg; buprenorphine 8 mg/naloxone 2 mg; buprenorphine 12 mg/naloxone 3 mg):\nDay 1 induction dose: Initial: Sublingual: Buprenorphine 2 mg/naloxone 0.5 mg or buprenorphine 4 mg/naloxone 1 mg; may titrate dose, based on control of acute withdrawal symptoms, in buprenorphine 2 mg/naloxone 0.5 mg or buprenorphine 4 mg/naloxone 1 mg increments approximately every 2 hours up to a total dose of buprenorphine 8 mg/naloxone 2 mg.\nDay 2 induction dose: Sublingual: Up to buprenorphine 16 mg/naloxone 4 mg as a single dose\nSublingual tablet (Zubsolv: Buprenorphine 0.7 mg/naloxone 0.18 mg, buprenorphine 1.4 mg/naloxone 0.36 mg, buprenorphine 2.9 mg/naloxone 0.71 mg, buprenorphine 5.7 mg/naloxone 1.4 mg, buprenorphine 8.6 mg/naloxone 2.1 mg, or buprenorphine 11.4 mg/naloxone 2.9 mg):\nDay 1 induction dose: Sublingual: Start with an initial dose of buprenorphine 1.4 mg/naloxone 0.36 mg; based on control of acute withdrawal symptoms, may administer additional doses in increments of 1 to 2 buprenorphine 1.4 mg/naloxone 0.36 mg tablets every 1.5 to 2 hours to a total day 1 dose up to buprenorphine 5.7 mg/naloxone 1.4 mg. Some patients (eg, those with recent exposure to buprenorphine) may tolerate up to buprenorphine 4.2 mg/naloxone 1.08 mg as a single, second dose.\nDay 2 induction dose: Sublingual: Up to buprenorphine 11.4 mg/naloxone 2.9 mg as a single dose\nMaintenance: \nBuccal film (Bunavail: Buprenorphine 2.1 mg/naloxone 0.3 mg, buprenorphine 4.2 mg/naloxone 0.7 mg, buprenorphine 6.3 mg/naloxone 1 mg): Buccal: Target dose: Buprenorphine 8.4 mg/naloxone 1.4 mg once daily; dosage should be adjusted in increments/decrements of buprenorphine 2.1 mg/naloxone 0.3 mg to a level that maintains treatment and suppresses opioid withdrawal symptoms; usual range: Buprenorphine 2.1 to 12.6 mg/naloxone 0.3 to 2.1 mg once daily.\nSublingual film (Suboxone: Buprenorphine 2 mg/naloxone 0.5 mg; buprenorphine 4 mg/naloxone 1 mg; buprenorphine 8 mg/naloxone 2 mg; buprenorphine 12 mg/naloxone 3 mg): Sublingual or buccal: Target dose: Buprenorphine 16 mg/naloxone 4 mg once daily; dosage should be adjusted in increments/decrements of buprenorphine 2 mg/naloxone 0.5 mg or buprenorphine 4 mg/naloxone 1 mg to a level that maintains treatment and suppresses opioid withdrawal symptoms; usual range: Buprenorphine 4 to 24 mg/naloxone 1 to 6 mg once daily.\nSublingual film (Cassipa: Buprenorphine 16 mg/naloxone 4 mg): Sublingual: Buprenorphine 16 mg/naloxone 4 mg once daily; dosage should be adjusted to a level that maintains treatment and suppresses opioid withdrawal symptoms. Note: Buprenorphine 16 mg/naloxone 4 mg sublingual film is only for use following titration from lower doses.\nSublingual tablet (buprenorphine 2 mg/naloxone 0.5 mg or buprenorphine 8 mg/naloxone 2 mg): Sublingual: Target dose: Buprenorphine 16 mg/naloxone 4 mg once daily; dosage should be adjusted in increments/decrements of buprenorphine 2 mg/naloxone 0.5 mg or buprenorphine 4 mg/naloxone 1 mg to a level that maintains treatment and suppresses opioid withdrawal symptoms; usual range: Buprenorphine 4 to 24 mg/naloxone 1 to 6 mg once daily. Doses higher than buprenorphine 24 mg/naloxone 6 mg have not been demonstrated to provide any clinical advantage.\nSublingual tablet (Zubsolv: Buprenorphine 0.7 mg/naloxone 0.18 mg, buprenorphine 1.4 mg/naloxone 0.36 mg, buprenorphine 2.9 mg/naloxone 0.71 mg, buprenorphine 5.7 mg/naloxone 1.4 mg, buprenorphine 8.6 mg/naloxone 2.1 mg, or buprenorphine 11.4 mg/naloxone 2.9 mg): Sublingual: Target dose: Buprenorphine 11.4 mg/naloxone 2.9 mg once daily; dosage should be adjusted in increments/decrements of buprenorphine 2.9 mg/naloxone 0.71 mg or lower to a level that maintains treatment and suppresses opioid withdrawal symptoms; usual range: Buprenorphine 2.9 to 17.2 mg/naloxone 0.71 to 4.2 mg once daily. Doses higher than buprenorphine 17.2 mg/naloxone 4.2 mg have not been demonstrated to provide any clinical advantage.\nSwitching between sublingual tablets and sublingual film: Same dosage should be used as the previous administered product. Note: Potential for greater bioavailability with certain sublingual film strengths compared to the same strength of the sublingual tablet; monitor closely for either over- or underdosing when switching patients from one formulation to another.\nSwitching between buccal film and sublingual tablets or films: Due to differences in the bioavailability of Bunavail buccal films compared to other buprenorphine/naloxone sublingual tablets, different strengths must be given to achieve equivalent doses. When switching between Bunavail and other sublingual tablets, corresponding dosage strengths are as follows:\nBunavail buprenorphine 2.1 mg/naloxone 0.3 mg = buprenorphine 4 mg/naloxone 1 mg sublingual tablets or films\nBunavail buprenorphine 4.2 mg/naloxone 0.7 mg = buprenorphine 8 mg/naloxone 2 mg sublingual tablets or films\nBunavail buprenorphine 6.3 mg/naloxone 1 mg = buprenorphine 12 mg/naloxone 3 mg sublingual tablets or films\nSwitching between sublingual film strengths:\nSystemic exposure may be different with various combinations of sublingual film strengths; pharmacists should not substitute one or more film strengths for another (eg, switching from three buprenorphine 4 mg/naloxone 1 mg films to a single buprenorphine 12 mg/naloxone 3 mg film, or vice-versa) without health care provider approval, and patients should be monitored closely for either over- or underdosing when switching between film strengths.\nCassipa: Patients may switch from two buprenorphine 8 mg/naloxone 2 mg sublingual films to a single buprenorphine 16 mg/ naloxone 4 mg sublingual film.\nSwitching between sublingual and buccal sites of administration (Suboxone): Systemic exposure between buccal and sublingual administration of buprenorphine/naloxone sublingual film is similar. Once induction is complete, patients can switch between buccal and sublingual administration without significant risk of under or overdosing.\nSwitching between sublingual tablet products: Due to differences in the bioavailability of Zubsolv sublingual tablets compared to other buprenorphine/naloxone sublingual tablets, different strengths must be given to achieve equivalent doses. When switching between Zubsolv and other sublingual tablets, corresponding dosage strengths are as follows:\nZubsolv buprenorphine 1.4 mg/naloxone 0.36 mg sublingual tablets = buprenorphine 2 mg/naloxone 0.5 mg sublingual tablets\nZubsolv buprenorphine 2.9 mg/naloxone 0.71 mg sublingual tablets = buprenorphine 4 mg/naloxone 1 mg (as two buprenorphine 2 mg/naloxone 0.5 mg sublingual tablets)\nZubsolv buprenorphine 5.7 mg/naloxone 1.4 mg sublingual tablets = buprenorphine 8 mg/naloxone 2 mg sublingual tablets\nZubsolv buprenorphine 8.6 mg/naloxone 2.1 mg sublingual tablet = buprenorphine 12 mg/naloxone 3 mg sublingual tablets (as one buprenorphine 8 mg/naloxone 2 mg sublingual tablets and two buprenorphine 2 mg/naloxone 0.5 mg sublingual tablets)\nZubsolv buprenorphine 11.4 mg/naloxone 2.9 mg sublingual tablet = buprenorphine 16 mg/naloxone 4 mg sublingual tablets (as two buprenorphine 8 mg/naloxone 2 mg sublingual tablets)\nCanadian labeling: Sublingual tablet: Note: Dose based on buprenorphine content.\nInduction: Day 1: Initial: 4 mg as single dose; may repeat dose if necessary depending on patient\'s requirement; target dose: 8 to 12 mg.\nMaintenance: Day 2 and beyond: Titrate per response in increments or decrements of 2 to 8 mg; usual maintenance dose: 12 to 16 mg once daily (maximum: 24 mg/day). Upon stabilization, may consider less frequent administration of corresponding equivalent dose (eg, 16 mg every other day instead of 8 mg/day or 3 times/week dosing [eg, Monday-Wednesday-Friday] with twice the maintenance dose on Monday and Wednesday and three times the maintenance dose on Friday); continue to limit maximum dose to 24 mg/day on any single day. Note: When switching dosing to less than once daily, monitor all patients for at least 90 minutes following the initial dose of the new regimen. The less frequent dosing regimen is not recommended in patients dependent on concurrent CNS-active drugs, including ethanol.\nMissed doses: Reassess patients who have missed multiple doses; initial induction doses may be required when resuming therapy.\nDiscontinuation of therapy: When discontinuing buprenorphine/naloxone for long-term treatment of opioid use disorder, gradually decrease the dose over several months (SAMHSA 2018).\nDosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.\n Detailed Buprenorphine/naloxone dosage information\nDosing: Geriatric\nRefer to adult dosing.\nDosing: Pediatric\nNote: Sublingual tablets and film contain a free-base ratio of buprenorphine:naloxone of 4:1. Not all sublingual dosage forms are bioequivalent and dosing adjustment or additional monitoring may be necessary when switching products; refer to specific dosing sections below. Doses based on buprenorphine content; titrate to appropriate effect.\nOpioid dependence, maintenance treatment (heroin or short-acting opioid) (ASAM [Kampman 2015]): Note: Buprenorphine alone (without naloxone) is preferred over the combination product for use during the induction period for long-acting opioids or methadone.\nAdolescents: Limited data available: Sublingual: Tablets or Film:\nInduction: Note: Combination products should only be administered for induction in patients dependent on short-acting opioids (eg, heroin, oxycodone) who have begun to show mild to moderate opioid withdrawal signs (to avoid precipitated withdrawal) and whose last dose of opioids was at least 6 to 12 hours prior to induction.\nInitial: 2 to 4 mg; if no signs of precipitated withdrawal after 60 to 90 minutes, may increase in increments of 2 to 4 mg. Once initial dose is tolerated, may increase to a dose that is clinically effective and provides 24 hours of stabilization.\nAfter induction and titration, daily doses usually ≥8 mg/day are necessary. In patients continuing to use opioids, consider increasing the dose by 4 to 8 mg to a daily dose of 12 to 16 mg/day. Maximum daily dose: 24 mg/day.\nSwitching between sublingual tablets and sublingual film: The same dosage should be used as the previous administered product with close patient monitoring. Note: Potential for greater bioavailability with certain sublingual film strengths compared to the same strength of the sublingual tablet; monitor closely for either over- or underdosing when switching patients from one formulation to another (ASAM [Kampman 2015]).\nSwitching between sublingual film strengths: Systemic exposure may be different with various combinations of sublingual film strengths; pharmacists should not substitute one or more film strengths for another (eg, switching from three buprenorphine 4 mg/naloxone 1 mg films to a single buprenorphine 12 mg/naloxone 3 mg film, or vice-versa) without health care provider approval, and patients should be monitored closely for either over- or underdosing when switching between film strengths.\nCassipa: Patients may switch from two buprenorphine 8 mg/naloxone 2 mg sublingual films to a single buprenorphine 16 mg/ naloxone 4 mg sublingual Cassipa film.\nSwitching between sublingual tablet products: Due to differences in the bioavailability of Zubsolv sublingual tablets compared to other buprenorphine/naloxone sublingual tablets, different strengths must be given to achieve equivalent doses. When switching between Zubsolv and other sublingual tablets, corresponding dosage strengths are as follows:\nZubsolv buprenorphine 1.4 mg/naloxone 0.36 mg sublingual tablets = buprenorphine 2 mg/naloxone 0.5 mg sublingual tablets.\nZubsolv buprenorphine 2.9 mg/naloxone 0.71 mg sublingual tablets = buprenorphine 4 mg/naloxone 1 mg (as two buprenorphine 2 mg/naloxone 0.5 mg sublingual tablets).\nZubsolv buprenorphine 5.7 mg/naloxone 1.4 mg sublingual tablets = buprenorphine 8 mg/naloxone 2 mg sublingual tablets.\nZubsolv buprenorphine 8.6 mg/naloxone 2.1 mg sublingual tablet = buprenorphine 12 mg/naloxone 3 mg sublingual tablets (as one buprenorphine 8 mg/naloxone 2 mg sublingual tablets and two buprenorphine 2 mg/naloxone 0.5 mg sublingual tablets).\nZubsolv buprenorphine 11.4 mg/naloxone 2.9 mg sublingual tablet = buprenorphine 16 mg/naloxone 4 mg sublingual tablets (as two buprenorphine 8 mg/naloxone 2 mg sublingual tablets).\nDosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.\nAdministration\nFilm:\nBunavail: Buccal: Although the manufacturer recommends administering the film whole without cutting, chewing, or swallowing, one stability study (using Suboxone brand) suggested that films split in half have uniform content and maintain stability for up to 7 days (Reindel 2019). Immediately before placing the film, moisten inside of cheek with tongue or water. Apply film with a dry finger immediately after removing it from packaging. Place film with the text (BN2, BN4, or BN6) against the inside of the moistened cheek; press and hold the film in place for 5 seconds with finger (film should stay in place after this period). Keep film in place until it dissolves completely. Do not chew, swallow or move film after placement. Liquids and food can be consumed after film dissolves. If using more than 1 film simultaneously, the additional film should be placed on the inside of the other cheek; no more than 2 films should be applied to the inside of one cheek at a time.\nCassipa: Sublingual: Although the manufacturer recommends administering the film whole without cutting, chewing, or swallowing, one stability study (using Suboxone brand) suggested that films split in half have uniform content and maintain stability for up to 7 days (Reindel 2019). Prior to film placement, rinse mouth with a small volume of room temperature water; avoid beverages with a high pH prior to dosing. Place one film under the tongue until the film completely dissolves, close to the base on the left or right side. Do not move film after placement. Liquids and food should not be consumed until after film completely dissolves.\nSuboxone: May be used buccally or sublingually.\nBuccal: Although the manufacturer recommends administering the film whole without cutting, chewing, or swallowing, one stability study suggested that films split in half have uniform content and maintain stability for up to 7 days (Reindel 2019). Place one film on the inside of the right or left cheek. If more than one film is needed, the additional film should be placed on the inside of the opposite cheek. Keep the film on the inside of the cheek until completely dissolved. Do not move film after placement. If a third film is necessary, place it on the inside of the right or left cheek after the first 2 films have dissolved.\nSublingual film: Although the manufacturer recommends administering the film whole without cutting, chewing, or swallowing, one stability study suggested that films split in half have uniform content and maintain stability for up to 7 days (Reindel 2019). Place one film under the tongue until the film completely dissolves, close to the base on the left or right side. If more than one film is needed, the additional film should be placed under the tongue on the opposite side from the first film. Place the film in a manner to minimize overlapping as much as possible. Do not move film after placement. If a third film is necessary to achieve the prescribed dose, place it under the tongue on either side after the first 2 films have dissolved.\nSublingual tablet: Immediately after removal from blister pack, tablet should be placed under the tongue until dissolved (can take up to 10 minutes to fully dissolve [SAMHSA 2018]). If 2 or more tablets are needed per dose, all may be placed under the tongue at once, or 2 at a time. In patients requiring more than one sublingual tablet, place all tablets in different places under the tongue at the same time. To ensure consistent bioavailability, subsequent doses should always be taken the same way. Patients should not eat or drink anything until the tablet(s) are completely dissolved. If a sequential mode of administration is preferred, patients should follow the same manner of dosing with continued use of the product, to ensure consistency in bioavailability. Do not chew or swallow sublingual tablets.\n','Abametapir: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination\nAlcohol (Ethyl): May enhance the CNS depressant effect of Buprenorphine. Management: Advise patients receiving buprenorphine about the increased risk of CNS depression if they consume alcohol.  Consider alternatives to buprenorphine for opioid addiction treatment in patients who are dependent on alcohol. Consider therapy modification\nAlizapride: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nAlvimopan: Opioid Agonists may enhance the adverse/toxic effect of Alvimopan. This is most notable for patients receiving long-term (i.e., more than 7 days) opiates prior to alvimopan initiation.  Management: Alvimopan is contraindicated in patients receiving therapeutic doses of opioids for more than 7 consecutive days immediately prior to alvimopan initiation. Consider therapy modification\nAmphetamines: May enhance the analgesic effect of Opioid Agonists. Monitor therapy\nAnticholinergic Agents: May enhance the adverse/toxic effect of Opioid Agonists. Specifically, the risk for constipation and urinary retention may be increased with this combination. Monitor therapy\nAprepitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nAtazanavir: Buprenorphine may decrease the serum concentration of Atazanavir. Atazanavir may increase the serum concentration of Buprenorphine.  Management: Avoid this combination in patients un-boosted atazanavir due to possible decreased atazanavir concentrations.  This combination is not contraindicated in patients also receiving ritonavir, but monitoring for buprenorphine toxicity is recommended. Avoid combination\nAzelastine (Nasal): May enhance the CNS depressant effect of CNS Depressants. Avoid combination\nBlonanserin: CNS Depressants may enhance the CNS depressant effect of Blonanserin.  Management: Use caution if coadministering blonanserin and CNS depressants; dose reduction of the other CNS depressant may be required. Strong CNS depressants should not be coadministered with blonanserin. Consider therapy modification\nBrimonidine (Topical): May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nBromopride: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nBromperidol: May enhance the CNS depressant effect of CNS Depressants. Avoid combination\nCannabidiol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nCannabis: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nChlormethiazole: May enhance the CNS depressant effect of CNS Depressants. Management: Monitor closely for evidence of excessive CNS depression. The chlormethiazole labeling states that an appropriately reduced dose should be used if such a combination must be used. Consider therapy modification\nChlorphenesin Carbamate: May enhance the adverse/toxic effect of CNS Depressants. Monitor therapy\nClofazimine: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nCNS Depressants: May enhance the CNS depressant effect of Buprenorphine. Management: Consider reduced doses of other CNS depressants, and avoiding such drugs in patients at high risk of buprenorphine overuse/self-injection. Initiate buprenorphine at lower doses in patients already receiving CNS depressants. Consider therapy modification\nCobicistat: May increase the serum concentration of Buprenorphine. Monitor therapy\nConivaptan: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination\nCYP3A4 Inducers (Moderate): May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nCYP3A4 Inducers (Strong): May decrease the serum concentration of Buprenorphine. Monitor therapy\nCYP3A4 Inhibitors (Moderate): May decrease the metabolism of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nCYP3A4 Inhibitors (Strong): May increase the serum concentration of Buprenorphine. Monitor therapy\nDabrafenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Seek alternatives to concomitant therapy when possible.  If concomitant therapy cannot be avoided, monitor for reduced clinical effects of the CYP3A4 substrate. Consider therapy modification\nDaclatasvir: May increase the serum concentration of Buprenorphine. Monitor therapy\nDeferasirox: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nDesmopressin: Opioid Agonists may enhance the adverse/toxic effect of Desmopressin.  Monitor therapy\nDimethindene (Topical): May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nDiuretics: Opioid Agonists may enhance the adverse/toxic effect of Diuretics. Opioid Agonists may diminish the therapeutic effect of Diuretics.  Monitor therapy\nDronabinol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nDroperidol: May enhance the CNS depressant effect of CNS Depressants. Management: Consider dose reductions of droperidol or of other CNS agents (eg, opioids, barbiturates) with concomitant use. Consider therapy modification\nDuvelisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nEfavirenz: May decrease serum concentrations of the active metabolite(s) of Buprenorphine. Efavirenz may decrease the serum concentration of Buprenorphine. Monitor therapy\nEluxadoline: Opioid Agonists may enhance the constipating effect of Eluxadoline.  Avoid combination\nEnzalutamide: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Concurrent use of enzalutamide with CYP3A4 substrates that have a narrow therapeutic index should be avoided.  Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring. Consider therapy modification\nErdafitinib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nErdafitinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nEtravirine: May decrease the serum concentration of Buprenorphine. Monitor therapy\nFlunitrazepam: CNS Depressants may enhance the CNS depressant effect of Flunitrazepam.  Management: Reduce the dose of CNS depressants when combined with flunitrazepam and monitor patients for evidence of CNS depression (eg, sedation, respiratory depression). Use non-CNS depressant alternatives when available. Consider therapy modification\nFosaprepitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nFosnetupitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nFusidic Acid (Systemic): May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination\nGastrointestinal Agents (Prokinetic): Opioid Agonists may diminish the therapeutic effect of Gastrointestinal Agents (Prokinetic).  Monitor therapy\nIdelalisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Avoid combination\nIvosidenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nKava Kava: May enhance the adverse/toxic effect of CNS Depressants. Monitor therapy\nLarotrectinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nLemborexant: May enhance the CNS depressant effect of CNS Depressants. Management: Dosage adjustments of lemborexant and of concomitant CNS depressants may be necessary when administered together because of potentially additive CNS depressant effects. Close monitoring for CNS depressant effects is necessary. Consider therapy modification\nLisuride: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nLofexidine: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nMagnesium Sulfate: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nMethotrimeprazine: CNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants.  Management: Reduce the usual dose of CNS depressants by 50% if starting methotrimeprazine until the dose of methotrimeprazine is stable. Monitor patient closely for evidence of CNS depression. Consider therapy modification\nMethylnaltrexone: May enhance the adverse/toxic effect of Opioid Antagonists. Specifically, the risk for opioid withdrawal may be increased. Avoid combination\nMetoclopramide: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nMetyroSINE: CNS Depressants may enhance the sedative effect of MetyroSINE.  Monitor therapy\nMiFEPRIStone: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Management: Minimize doses of CYP3A4 substrates, and monitor for increased concentrations/toxicity, during and 2 weeks following treatment with mifepristone. Avoid cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus. Consider therapy modification\nMinocycline (Systemic): May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nMitotane: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Consider therapy modification\nMonoamine Oxidase Inhibitors: Buprenorphine may enhance the adverse/toxic effect of Monoamine Oxidase Inhibitors.  Avoid combination\nNabilone: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nNaldemedine: Opioid Antagonists may enhance the adverse/toxic effect of Naldemedine. Specifically, the risk for opioid withdrawal may be increased.  Avoid combination\nNalmefene: May diminish the therapeutic effect of Opioid Agonists. Management: Avoid the concomitant use of nalmefene and opioid agonists. Discontinue nalmefene 1 week prior to any anticipated use of opioid agonistss. If combined, larger doses of opioid agonists will likely be required. Consider therapy modification\nNaloxegol: Opioid Antagonists may enhance the adverse/toxic effect of Naloxegol. Specifically, the risk for opioid withdrawal may be increased.  Avoid combination\nNaltrexone: May diminish the therapeutic effect of Opioid Agonists. Management: Seek therapeutic alternatives to opioids.  See full drug interaction monograph for detailed recommendations. Avoid combination\nNefazodone: Opioid Agonists (metabolized by CYP3A4) may enhance the serotonergic effect of Nefazodone. This could result in serotonin syndrome. Nefazodone may increase the serum concentration of Opioid Agonists (metabolized by CYP3A4).  Management: If concomitant use of opioid agonists that are metabolized by CYP3A4 and nefazodone is necessary, consider dose reduction of the opioid until stable drug effects are achieved. Monitor for increased opioid effects and serotonin syndrome/serotonin toxicity. Consider therapy modification\nNetupitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nOmbitasvir, Paritaprevir, and Ritonavir: May increase the serum concentration of Buprenorphine. Monitor therapy\nOmbitasvir, Paritaprevir, Ritonavir, and Dasabuvir: May increase the serum concentration of Buprenorphine. Monitor therapy\nOpioid Agonists: Opioids (Mixed Agonist / Antagonist) may diminish the analgesic effect of Opioid Agonists.  Management: Seek alternatives to mixed agonist/antagonist opioids in patients receiving pure opioid agonists, and monitor for symptoms of therapeutic failure/high dose requirements (or withdrawal in opioid-dependent patients) if patients receive these combinations. Avoid combination\nOpioids (Mixed Agonist / Antagonist): May diminish the therapeutic effect of Buprenorphine. This combination may also induce opioid withdrawal. Avoid combination\nOrphenadrine: CNS Depressants may enhance the CNS depressant effect of Orphenadrine.  Avoid combination\nOxomemazine: May enhance the CNS depressant effect of CNS Depressants. Avoid combination\nPalbociclib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nParaldehyde: CNS Depressants may enhance the CNS depressant effect of Paraldehyde.  Avoid combination\nPegvisomant: Opioid Agonists may diminish the therapeutic effect of Pegvisomant.  Monitor therapy\nPerampanel: May enhance the CNS depressant effect of CNS Depressants. Management: Patients taking perampanel with any other drug that has CNS depressant activities should avoid complex and high-risk activities, particularly those such as driving that require alertness and coordination, until they have experience using the combination. Consider therapy modification\nPHENobarbital: May enhance the CNS depressant effect of Buprenorphine. PHENobarbital may decrease the serum concentration of Buprenorphine. Management: Avoid use of buprenorphine and phenobarbital when possible. Monitor for respiratory depression/sedation. Because phenobarbital is also a strong CYP3A4 inducer, monitor for decreased buprenorphine efficacy and withdrawal if combined. Consider therapy modification\nPiribedil: CNS Depressants may enhance the CNS depressant effect of Piribedil.  Monitor therapy\nPramipexole: CNS Depressants may enhance the sedative effect of Pramipexole.  Monitor therapy\nPrimidone: May enhance the CNS depressant effect of Buprenorphine. Primidone may decrease the serum concentration of Buprenorphine. Management: Avoid use of buprenorphine and primidone when possible. Monitor for respiratory depression/sedation. Because primidone is also a strong CYP3A4 inducer, monitor for decreased buprenorphine efficacy and withdrawal if combined. Consider therapy modification\nQT-prolonging Agents (Highest Risk): QT-prolonging Agents (Indeterminate Risk - Avoid) may enhance the QTc-prolonging effect of QT-prolonging Agents (Highest Risk).  Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Monitor therapy\nRamosetron: Opioid Agonists may enhance the constipating effect of Ramosetron.  Monitor therapy\nRifabutin: May decrease the serum concentration of Buprenorphine. Monitor therapy\nROPINIRole: CNS Depressants may enhance the sedative effect of ROPINIRole.  Monitor therapy\nRotigotine: CNS Depressants may enhance the sedative effect of Rotigotine.  Monitor therapy\nRufinamide: May enhance the adverse/toxic effect of CNS Depressants. Specifically, sleepiness and dizziness may be enhanced. Monitor therapy\nSarilumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nSerotonergic Agents (High Risk): Opioid Agonists (metabolized by CYP3A4) may enhance the serotonergic effect of Serotonergic Agents (High Risk). This could result in serotonin syndrome.  Management: Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when these agents are combined. Monitor therapy\nSiltuximab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nSimeprevir: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy\nSincalide: Drugs that Affect Gallbladder Function may diminish the therapeutic effect of Sincalide.  Management: Consider discontinuing drugs that may affect gallbladder motility prior to the use of sincalide to stimulate gallbladder contraction. Consider therapy modification\nStiripentol: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity.  Any CYP3A4 substrate used with stiripentol requires closer monitoring. Consider therapy modification\nSuccinylcholine: May enhance the bradycardic effect of Opioid Agonists. Monitor therapy\nSuvorexant: CNS Depressants may enhance the CNS depressant effect of Suvorexant.  Management: Dose reduction of suvorexant and/or any other CNS depressant may be necessary.  Use of suvorexant with alcohol is not recommended, and the use of suvorexant with any other drug to treat insomnia is not recommended. Consider therapy modification\nTetrahydrocannabinol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nTetrahydrocannabinol and Cannabidiol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy\nThalidomide: CNS Depressants may enhance the CNS depressant effect of Thalidomide.  Avoid combination\nTocilizumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy\nZolpidem: CNS Depressants may enhance the CNS depressant effect of Zolpidem.  Management: Reduce the Intermezzo brand sublingual zolpidem adult dose to 1.75 mg for  men who are also receiving other CNS depressants. No such dose change is recommended for women. Avoid use with other CNS depressants at bedtime; avoid use with alcohol. Consider therapy modification\n Buprenorphine/naloxone drug interactions (more detail)\nAdverse Reactions\nThe following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Also see individual agents.\n>10%:\nCentral nervous system: Headache (7% to 37%), pain (22%)\nDermatologic: Diaphoresis (>1% to 14%)\nGastrointestinal: Nausea (sublingual tablet: 5% to 15%), constipation (>1% to 12%), abdominal pain (11%)\n1% to 10%:\nCardiovascular: Vasodilation (9%), palpitations (sublingual film: >1%)\nCentral nervous system: Disturbance in attention (sublingual film: >1%), insomnia (>1%), intoxicated feeling (sublingual film: >1%), withdrawal syndrome (>1%)\nGastrointestinal: Vomiting (5% to 8%), glossalgia (sublingual film: >1%), oral hypoesthesia (sublingual film: >1%), oral mucosa erythema (sublingual film: >1%)\nOphthalmic: Blurred vision (sublingual film: >1%)\nFrequency not defined:\nCentral nervous system: Anxiety, irritability, restlessness\nDermatologic: Piloerection\nGastrointestinal: Stomach discomfort\nNeuromuscular & skeletal: Arthralgia\nOphthalmic: Increased lacrimation\nRespiratory: Rhinorrhea\n<1%, postmarketing, and/or case reports: Glossitis, oral bullae, oral mucosa ulcer, peripheral edema, stomatitis\n',NULL,'Opioid use disorder: Treatment of opioid use disorder.\nGeneral information: Buprenorphine/naloxone should be used as part of a complete treatment plan to include counseling and psychosocial support.\n','Concerns related to adverse effects:\n• CNS depression: May cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (eg, operating machinery, driving).\n• Hepatic events: Hepatitis has been reported; hepatic events ranged from transient, asymptomatic transaminase elevations to hepatic failure; in many cases, patients had preexisting hepatic impairment. Monitor liver function tests in patients at increased risk for hepatotoxicity (eg, history of alcohol or IV drug abuse, preexisting hepatic dysfunction) prior to and during therapy.\n• Hypersensitivity reactions: Hypersensitivity, including bronchospasm, angioneurotic edema, and anaphylactic shock, have been reported.\n• Hypotension: May cause severe hypotension, including orthostatic hypotension and syncope; use with caution in patients with hypovolemia, cardiovascular disease (including acute MI), or drugs that may exaggerate hypotensive effects (including phenothiazines or general anesthetics). Monitor for symptoms of hypotension following initiation or dose titration. Use with caution in patients with circulatory shock.\n• Respiratory depression: Serious, life-threatening, or fatal respiratory depression may occur. Monitor closely for respiratory depression, especially during initiation or dose escalation. Misuse by self-injection of buprenorphine or the concomitant use of buprenorphine and benzodiazepines (or other CNS depressants, including alcohol) may result in coma or death. Use with caution in patients with compromised respiratory function (eg, chronic obstructive pulmonary disease, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or preexisting respiratory depression). Patients and caregivers should be educated on how to recognize respiratory depression and the importance of getting emergency assistance immediately (eg, calling 911) in the event of known or suspected overdose.\nDisease-related concerns:\n• Abdominal conditions: May obscure diagnosis or clinical course of patients with acute abdominal conditions.\n• Adrenocortical insufficiency: Use with caution in patients with adrenal insufficiency, including Addison disease. Long-term opioid use may cause secondary hypogonadism, which may lead to mood disorders and osteoporosis (Brennan 2013).\n• Biliary tract impairment: Use with caution in patients with biliary tract dysfunction, including acute pancreatitis; opioids may cause constriction of sphincter of Oddi.\n• Bowel obstruction: Use with caution in patients with a history of ileus or bowel obstruction.\n• CNS depression/coma: Use with caution in patients with impaired consciousness or coma because these patients are susceptible to intracranial effects of CO2 retention.\n• Delirium tremens: Use with caution in patients with delirium tremens.\n• Head trauma: Use with extreme caution in patients with head injury, intracranial lesions, or elevated intracranial pressure; exaggerated elevation of ICP may occur. Buprenorphine can produce miosis and changes in the level of consciousness that may interfere with patient evaluation.\n• Hepatic impairment: Use is not recommended in patients with moderate hepatic impairment for induction therapy (Suboxone) or in patients with severe hepatic impairment. Use with caution in patients with moderate hepatic impairment for maintenance treatment; due to reduced clearance of naloxone and potential for reduced buprenorphine efficacy, use may not be appropriate.\n• Obesity: Use with caution in patients who are morbidly obese (DeVido 2015).\n• Prostatic hyperplasia/urinary stricture: Use with caution in patients with prostatic hyperplasia and/or urinary stricture.\n• Psychosis: Use with caution in patients with toxic psychosis.\n• Respiratory disease: Use with caution and monitor for respiratory depression in patients with significant chronic obstructive pulmonary disease, cor pulmonale, or kyphoscoliosis, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or preexisting respiratory depression, particularly when initiating and titrating therapy; critical respiratory depression may occur, even at therapeutic dosages.\n• Seizure: Use with caution in patients with a history of seizure disorders; may cause or exacerbate preexisting seizures.\n• Sleep-related disorders: Opioid use increases the risk for sleep-related disorders (eg, central sleep apnea [CSA], hypoxemia) in a dose-dependent fashion. Use with caution and titrate dosage cautiously in patients with risk factors for sleep-disordered breathing (eg, heart failure, obesity). Consider dose reduction in patients presenting with CSA. Avoid opioids in patients with moderate to severe sleep-disordered breathing (CDC [Dowell 2016]).\n• Thyroid dysfunction: Use with caution in patients with thyroid dysfunction.\nConcurrent drug therapy issues:\n• Benzodiazepines and other CNS depressants: Concomitant use of benzodiazepines or other CNS depressants, including alcohol and opioids, may result in profound sedation, respiratory depression, coma, and death. Prohibiting medication-assisted treatment of opioid use disorder may increase the risk of morbidity and mortality, therefore patients should be educated on the risks of concomitant use with benzodiazepines, sedatives, opioid analgesics, and alcohol. Strategies should be developed to manage use of prescribed or illicit benzodiazepines or other CNS depressants at initiation of or during treatment with buprenorphine; adjustments to induction procedures and additional monitoring may be required. If appropriate, delay or omit buprenorphine dose if a patient is sedated at time of buprenorphine dosing. Discontinuation of benzodiazepines or other CNS depressants is preferred; gradual tapering of benzodiazepine or other CNS depressant, decreasing to lowest effective dose, or monitoring in a higher level of care for taper may be appropriate. Consider prescribing naloxone for emergency treatment of opioid overdose in patients taking benzodiazepines or other CNS depressants concomitantly with opioids. Benzodiazepines are not the treatment of choice for anxiety or insomnia for patients in buprenorphine treatment; make sure patients are appropriately diagnosed and consider alternative medications for anxiety and insomnia prior to coadministration of benzodiazepines and buprenorphine.\nSpecial populations:\n• Cachectic or debilitated patients: Use with caution in cachectic or debilitated patients; there is a greater potential for life-threatening respiratory depression, even at therapeutic dosages.\n• Elderly: Use with caution in elderly patients; may be more sensitive to adverse effects (eg, life-threatening respiratory depression).\n• Neonates: Neonatal withdrawal syndrome: Prolonged use of opioids during pregnancy can cause neonatal withdrawal syndrome, which may be life-threatening if not recognized and treated according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal withdrawal syndrome and ensure that appropriate treatment will be available. Signs and symptoms include irritability, hyperactivity and abnormal sleep pattern, high-pitched cry, tremor, vomiting, diarrhea, and failure to gain weight. Onset, duration, and severity depend on the drug used, duration of use, maternal dose, and rate of drug elimination by the newborn.\nSpecial handling:\n• Disposal: Dispose of unused buccal and sublingual films (if they are no longer needed) by removing from foil patch and flushing down the toilet. If multiple films are no longer needed, flush each film individually.\nOther warnings/precautions:\n• Accidental ingestion: Accidental ingestion in children can result in severe respiratory depression (may be fatal); store buprenorphine-containing medications out of reach of children and dispose of unused medication appropriately.\n• Acute pain: When using buprenorphine for treatment of opioid use disorder, treat acute pain with nonopioid analgesics whenever possible. If treatment with a high-affinity full opioid analgesic is required, monitor closely for respiratory depression because high doses may be necessary to achieve pain relief.\n• Addiction/abuse/misuse: Use exposes patients and other users to the risks of addiction, abuse, and misuse, potentially leading to overdose and death. Assess each patient\'s risk prior to prescribing; monitor all patients regularly for development of these behaviors or conditions. Use with caution in patients with a history of substance use disorder; potential for opioid use disorder exists. Other factors associated with an increased risk for misuse include younger age and psychotropic medication use. Consider offering naloxone prescriptions in patients with factors associated with an increased risk for overdose, such as history of overdose or substance use disorder, higher opioid dosages (≥50 morphine milligram equivalents/day orally), and concomitant benzodiazepine use (Dowell [CDC 2016]).\n• Appropriate use: Buprenorphine/naloxone is not appropriate for pain management; deaths have been reported in opioid-naive patients receiving oral buprenorphine for analgesia.\n• Discontinuation of therapy: There is no maximum recommended duration for maintenance treatment of opioid use disorder; patients may require treatment indefinitely. Advise patients of the potential to relapse to illicit drug use following discontinuation of opioid agonist/partial agonist medication-assisted treatment.\n• Naloxone access: Discuss the availability of naloxone with all patients who are prescribed opioid analgesics, as well as their caregivers, and consider prescribing it to patients who are at increased risk of opioid overdose. These include patients who are also taking benzodiazepines or other CNS depressants, have an opioid use disorder (OUD) (current or history of), or have experienced a previous opioid overdose. Additionally, health care providers should consider prescribing naloxone to patients prescribed medications to treat OUD; patients at risk of opioid overdose even if they are not taking an opioid analgesic or medication to treat OUD; and patients taking opioids, including methadone or buprenorphine for OUD, if they have household members, including children, or other close contacts at risk for accidental ingestion or opioid overdose. Inform patients and caregivers on options for obtaining naloxone (eg, by prescription, directly from a pharmacist, a community-based program) as permitted by state dispensing and prescribing guidelines. Educate patients and caregivers on how to recognize respiratory depression, proper administration of naloxone, and getting emergency help.\n• Partial opioid agonist and mixed opioid agonist/antagonist overdose: Reversal of partial opioid agonists or mixed opioid agonist/antagonists (eg, buprenorphine, pentazocine) may be incomplete and higher than normal doses and repeated administration of naloxone may be required.\n• Withdrawal: Concurrent use of opioid agonist/antagonist analgesics may precipitate withdrawal symptoms and/or reduced analgesic efficacy in patients following prolonged therapy with mu opioid agonists. Abrupt discontinuation following prolonged use may also lead to withdrawal symptoms and is not recommended; taper dose gradually when discontinuing. Treatment of opioid use disorder with buprenorphine/naloxone should not be started until effects of withdrawal are evident.\nMonitoring Parameters\nLiver function tests (prior to initiation and periodically during therapy); pregnancy test (prior to initiation); hepatitis and HIV tests (prior to initiation), particularly for patients with opioid use disorder (SAMHSA 2018); respiratory and mental status; CNS depression; blood pressure; symptoms of withdrawal; signs of dependence, abuse, or misuse; signs or symptoms of hypogonadism or hypoadrenalism (Brennan 2013).\nReproductive Considerations\nPregnancy testing is recommended prior to initiating therapy for opioid use disorders (SAMHSA 2018). Long-term opioid use may cause infertility in males and females of reproductive potential. Amenorrhea may develop secondary to substance abuse. Initiation of buprenorphine maintenance treatment may improve fertility resulting in unplanned pregnancy. Contraception counseling is recommended (Dow 2012).\n',NULL),(114,'buprenorphine-and-naloxone-oral-sublingual','Follow the directions on your prescription label and read all medication guides. Never use buprenorphine and naloxone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of  buprenorphine and naloxone.\nNever share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.\nRead and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.\nIf you switch between medicines containing buprenorphine, you may not use the same dose for each one. Follow all directions carefully.\nDo not stop using buprenorphine and naloxone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.\nYou will need frequent blood tests to check your liver function.\nAll your medical care providers should know that you are being treated for opioid addiction, and that you take buprenorphine and naloxone. Make sure your family members know how to provide this information in case they need to speak for you during an emergency.\nNever crush or break a buprenorphine and naloxone pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.\nStore this medicine in the foil pouch at room temperature, away from moisture and heat. Discard an empty pouch in a place children and pets cannot get to. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.\nDo not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, remove any unused films from the foil pack and flush the films down the toilet. Throw the empty foil pack into the trash.\n Detailed Buprenorphine/naloxone dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opioid overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.\n','You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.\nOpioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:\ncold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic (\"water pill\");\nmedicines for motion sickness, irritable bowel syndrome, or overactive bladder;\nother opioids--opioid pain medicine or prescription cough medicine;\na sedative like Valium--diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and others;\ndrugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or\ndrugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson\'s disease, migraine headaches, serious infections, or nausea and vomiting.\nThis list is not complete. Other drugs may affect buprenorphine and naloxone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.\n Buprenorphine/naloxone drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nOpioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.\nCall your doctor at once or seek emergency medical attention if you have:\nweak or shallow breathing, breathing that stops during sleep;\na light-headed feeling, like you might pass out;\nconfusion, loss of coordination, extreme weakness;\nblurred vision, slurred speech;\nliver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);\nhigh levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea;\nlow cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or\nopioid withdrawal symptoms--shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain.\nSerious breathing problems may be more likely in older adults and those who are debilitated or have wasting syndrome or chronic breathing disorders.\nCommon side effects may include:\ndizziness, drowsiness, blurred vision, feeling drunk, trouble concentrating;\nwithdrawal symptoms;\ntongue pain, redness or numbness inside your mouth;\nnausea, vomiting, constipation;\nheadache, back pain;\nfast or pounding heartbeats, increased sweating; or\nsleep problems (insomnia).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Buprenorphine/naloxone side effects (more detail)\n','Buprenorphine and naloxone is a combination medicine used to treat opioid addiction. Buprenorphine and naloxone is not for use as a pain medication.\nBuprenorphine and naloxone may also be used for purposes not listed in this medication guide.\n','MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.\nTaking  buprenorphine and naloxone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\nFatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to buprenorphine or naloxone (Narcan).\nTell your doctor if you have ever had:\nbreathing problems, sleep apnea;\nenlarged prostate, urination problems;\nliver or kidney disease;\nabnormal curvature of the spine that affects breathing;\nproblems with your gallbladder, adrenal gland, or thyroid;\na head injury, brain tumor, or seizures; or\nalcoholism or drug addiction.\nIf you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.\nAsk a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.\n','Do not drink alcohol. Dangerous side effects or death could occur.\nAvoid driving or operating machinery until you know how  buprenorphine and naloxone will affect you. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries.\n'),(115,'bupropion','Take bupropion exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure.\nDo not crush, chew, or break an extended-release tablet. Swallow the tablet whole.\nYou should not change your dose or stop using bupropion suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms.\nIf you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 to 12 weeks.\nYour doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.\nSome people taking bupropion (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with bupropion.\nYou may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.\nSmoking cessation may also cause new or worsening mental health problems, such as depression.\nThis medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion.\nStore at room temperature away from moisture and heat.\n Detailed Bupropion dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.\n','You may have a higher risk of seizures if you use certain other medicines while taking bupropion.\nMany drugs can interact with bupropion. Tell your doctor about all medicines you use, and those you start or stop using during your treatment. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Bupropion drug interactions (more detail)\n','Get emergency medical help if you have any of these signs of an allergic reaction to bupropion: (hives, itching, fever, swollen glands, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, depression, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\na seizure (convulsions);\nconfusion, unusual changes in mood or behavior;\nblurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;\nfast or irregular heartbeats; or\na manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep.\nCommon bupropion side effects may include:\ndry mouth, sore throat, stuffy nose;\nringing in the ears;\nblurred vision;\nnausea, vomiting, stomach pain, loss of appetite, constipation;\nsleep problems (insomnia);\ntremors, sweating, feeling anxious or nervous;\nfast heartbeats;\nconfusion, agitation, hostility;\nrash;\nweight loss;\nincreased urination;\nheadache, dizziness; or\nmuscle or joint pain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bupropion side effects (more detail)\n','Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder.\nThe Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.\nBupropion may also be used for purposes not listed in this medication guide.\n','You should not take bupropion if you have seizures or an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.\nDo not use bupropion within 14 days before or 14 days after you have used a MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.\nSome young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nBupropion may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nBefore taking this medicine\nDo not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.\nYou should not take bupropion if you are allergic to it, or if you have ever had:\na seizure disorder;\nan eating disorder such as anorexia or bulimia; or\nif you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).\nDo not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.\nDo not take this medicine to treat more than one condition at a time. If you take bupropion for depression, do not also take this medicine to quit smoking.\nBupropion may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\na head injury, seizures, or brain or spinal cord tumor;\nnarrow-angle glaucoma;\nheart disease, high blood pressure, or a heart attack;\ndiabetes;\nkidney or liver disease (especially cirrhosis);\ndepression, bipolar disorder or other mental illness; or\nif you drink alcohol.\nSome young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nAsk your doctor about taking this medicine if you are pregnant. It is not known whether bupropion will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking bupropion without your doctor\'s advice.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby.\nIt may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.\nBupropion is not approved for use by anyone younger than 18 years old.\n','Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. This medicine can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.\nBupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\n'),(116,'buspar','Take BuSpar exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nYou may take BuSpar with or without food but take it the same way each time.\nSome BuSpar tablets are scored so you can break the tablet into 2 or 3 pieces in order to take a smaller amount of the medicine at each dose. Do not use a tablet if it has not been broken correctly and the piece is too big or too small. Follow your doctor\'s instructions about how much of the tablet to take.\nIf you have switched to BuSpar from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use.\nBuspirone can cause false positive results with certain medical tests. You may need to stop using the medicine for at least 48 hours before your test. Tell any doctor who treats you that you are using BuSpar.\nStore at room temperature away from moisture, heat, and light.\n Detailed BuSpar dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. Although no deaths have been reported following BuSpar overdose, symptoms may include nausea, vomiting, dizziness, drowsiness or sleepiness, and stomach upset.\n','Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. The following medications can interact with BuSpar;\nMAO Inihibitors (including isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine as well as methylene blue injection);\nAmitriptyline;\nDiazepam;\nHaloperidol;\nNefazodone;\nTrazodone;\nTriazolam or flurazepam;\nDiltiazem or verapamil;\nAntibiotics, including erythromycin and rifampin;\nAntifungals, including itraconazole; or\nCimetidine.\nIn addition, sleeping pills, narcotic pain medicine, muscle relaxers, and other medications for anxiety, depression, or seizures may interact with Buspar.\nOther drugs not mentioned here may interact with buspirone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n BuSpar drug interactions (more detail)\n','Get emergency medical help if you have any signs of an allergic reaction to BuSpar: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nchest pain;\nshortness of breath; or\na light-headed feeling, like you might pass out.\nCommon BuSpar side effects may include:\nheadache;\ndizziness, drowsiness;\nsleep problems (insomnia);\nnausea, upset stomach; or\nfeeling nervous or excited.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n BuSpar side effects (more detail)\n','BuSpar (buspirone) is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety.\nBuSpar is used to treat anxiety disorders or the symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms.\nBuSpar is not an anti-psychotic medication and should not be used in place of medication prescribed by your doctor for mental illness.\nBuSpar may also be used for purposes not listed in this medication guide.\n','Do not use BuSpar if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.\nBefore taking this medicine\nYou should not use BuSpar if you are allergic to buspirone.\nDo not use BuSpar if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.\nTo make sure BuSpar is safe for you, tell your doctor if you have any of these conditions:\nkidney disease; or\nliver disease.\nBuSpar is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.\nIt is not known whether buspirone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nBuspirone is not FDA-approved for use by anyone younger than 18 years old, but has been used in children in adolescents under close medical supervision. Do not give buspirone to anyone younger than 18 years of age without consulting with a doctor.\n','This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDrinking alcohol may increase certain side effects of BuSpar.\nGrapefruit and grapefruit juice may interact with buspirone and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.\n'),(117,'buspirone','Usual Adult Dose for Anxiety:\nInitial dose: 7.5 mg orally two times a day or 5 mg 3 times a day.\nMaintenance dose: The daily dose may be increased in 5 mg increments every 2 to 3 days up to 20 to 60 mg/day in divided doses.\nMaximum dose: 60 mg per day\n Detailed Buspirone dosage information\n','Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking buspirone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.\nOther drugs may interact with buspirone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Buspirone drug interactions (more detail)\n','Get emergency medical help if you have any signs of an allergic reaction to buspirone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nchest pain;\nshortness of breath; or\na light-headed feeling, like you might pass out.\nCommon buspirone side effects may include:\nheadache;\ndizziness, drowsiness;\nsleep problems (insomnia);\nnausea, upset stomach; or\nfeeling nervous or excited.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Buspirone side effects (more detail)\n','Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety.\nBuspirone is used to treat symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms.\nBuspirone is not an anti-psychotic medication and should not be used in place of medication prescribed by your doctor for psychotic disorders.\n','Do not use buspirone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.\nBefore taking this medicine\nYou should not use buspirone if you are allergic to it.\nDo not use buspirone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.\nTo make sure this medicine is safe for you, tell your doctor if you have any of these conditions:\nkidney disease; or\nliver disease.\nBuspirone is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.\nIt is not known whether buspirone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.\nBuspirone is not FDA-approved for use by anyone younger than 18 years old, but this medicine has been used in children and adolescents under close medical supervision and at the appropriate dosage.\nHow should I take buspirone?\nTake buspirone exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nYou may take buspirone with or without food but take it the same way each time.\nSome buspirone tablets are scored so you can break the tablet into 2 or 3 pieces in order to take a smaller amount of the medicine at each dose. Do not use a tablet if it has not been broken correctly and the piece is too big or too small. Follow your doctor\'s instructions about how much of the tablet to take.\nIf you have switched to buspirone from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use.\nThis medication can cause false positive results with certain medical tests. You may need to stop using the medicine for at least 48 hours before your test. Tell any doctor who treats you that you are using buspirone.\nStore at room temperature away from moisture, heat, and light.\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDrinking alcohol may increase certain side effects of buspirone.\nGrapefruit and grapefruit juice may interact with buspirone and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.\n'),(118,'butalbital-compound','Follow all directions on your prescription label. Never use Butalbital Compound in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your headache.\nButalbital may be habit-forming. Never share Butalbital Compound with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.\nMisuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.\nIf you need surgery, tell the surgeon ahead of time that you are using Butalbital Compound. You may need to stop using the medicine for a short time.\nDo not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Butalbital Compound.\nStore at room temperature away from moisture and heat.\nKeep track of the amount of medicine used from each new bottle. Butalbital Compound is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.\n Detailed Butalbital Compound dosage information\nWhat happens if I miss a dose?\nSince  Butalbital Compound is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of butalbital can be fatal.\nOverdose symptoms may include extreme drowsiness, confusion, restless feeling, insomnia, tremors, fast heart rate, vomiting, stomach pain, rapid breathing, feeling hot, ringing in your ears, weak or shallow breathing, seizure (convulsions), or fainting.\n','Taking  Butalbital Compound with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.\nYou should not use Butalbital Compound if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.\nTell your doctor about all your current medicines and any you start or stop using, especially:\nmercaptopurine;\nmethotrexate;\nprobenecid;\ninsulin or oral diabetes medicine;\na blood thinner--warfarin, Coumadin, Jantoven; or\nsteroid medicine--prednisone, dexamethasone, and others.\nThis list is not complete. Other drugs may interact with aspirin, butalbital, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Butalbital Compound drug interactions (more detail)\nDoes Butalbital Compound interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nshallow breathing, slow heart rate;\nfast or pounding heart rate, muscle twitching;\nconfusion, unusual thoughts or behavior;\nsymptoms of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;\nproblems with urination; or\neasy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.\nSerious side effects may be more likely in older adults and those who are ill or debilitated.\nCommon side effects include:\ndrowsiness, dizziness;\nnausea, gas, upset stomach, stomach pain; or\nsleep problems (insomnia).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Butalbital Compound side effects (more detail)\n','Aspirin is a pain reliever, as well as an anti-inflammatory and a fever reducer.\nButalbital is a barbiturate. It relaxes muscle contractions involved in a tension headache.\nCaffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.\nButalbital Compound is a combination medicine used to treat tension headaches.  Butalbital Compound is not for treating headaches that come and go.\nButalbital Compound may also be used for purposes not those listed in this medication guide.\n','You should not use this medicine if you have a stomach ulcer, severe liver disease, porphyria, a bleeding or blood clotting disorder, or if you are allergic to any NSAID.\nAspirin may cause stomach or intestinal bleeding, which can be fatal.\nStop using Butalbital Compound and call your doctor at once if you have: black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.\nAspirin should not be given to a child or teenager who has a fever.\nButalbital may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.\nBefore taking this medicine\nAspirin may cause stomach or intestinal bleeding, which can be fatal. This can occur without warning while you are taking  Butalbital Compound.\nYou should not use this medicine if you are allergic to aspirin, butalbital, or caffeine, or if you have:\nstomach ulcer;\nsevere liver disease;\nporphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);\na bleeding or blood clotting disorder (such as hemophilia); or\nasthma, or a history of severe allergic reaction (sneezing, runny or stuffy nose, wheezing, shortness of breath) after taking aspirin or another NSAID (nonsteroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Celebrex, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.\nTo make sure Butalbital Compound is safe for you, tell your doctor if you have:\nliver or kidney disease;\nasthma or another respiratory disease;\nfluid retention;\nheart disease, congestive heart failure, high blood pressure;\na history of head injury or brain tumor;\na stomach or intestinal disorder;\na thyroid disorder;\nenlarged prostate or urination problems; or\nAddison\'s disease (an adrenal gland disorder).\nIt is not known whether this medicine will harm an unborn baby. If you use butalbital while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.\nAspirin, butalbital, and caffeine can pass into breast milk and may harm a nursing baby. Aspirin use while breast-feeding could cause bleeding in the infant. You should not breast-feed while using this medicine.\nDo not give this medicine to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye\'s syndrome, a serious and sometimes fatal condition in children.\n','This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how the medicine will affect you.\nAsk a doctor or pharmacist before using any cough, cold, allergy, or pain medication. Aspirin and caffeine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains aspirin or caffeine.\nDo not drink alcohol. Dangerous side effects, overdose, or death can occur when alcohol is combined with butalbital. Alcohol may increase your risk of stomach bleeding while you are taking aspirin.\n'),(119,'bystolic','Take Bystolic exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.\nTake Bystolic at the same time every day. You may take the medication with or without food.\nDo not skip doses or stop taking Bystolic without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems such as severe chest pain or heart attack. You may need to use less and less before you stop the medication completely.\nYour blood pressure will need to be checked often. Visit your doctor regularly.\nIf you need surgery, tell the surgeon ahead of time that you are using Bystolic.\nBystolic is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.\nKeep using Bystolic as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nStore Bystolic at room temperature away from moisture and heat.\n Detailed Bystolic dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include slow heart rate, dizziness, vomiting, trouble breathing, or feeling like you might pass out.\n','Tell your doctor about all other medicines you use, especially:\ncimetidine (Tagamet);\nclonidine (Catapres);\ndigitalis (digoxin, Lanoxin);\nisoniazid (for treating tuberculosis);\nmethimazole (Tapazole);\nreserpine;\nropinirole (Requip);\nticlopidine (Ticlid);\nanother beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;\nan antibiotic such as terbinafine (Lamisil);\nan antidepressant such as clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), imipramine (Tofranil), paroxetine (Paxil, Pexeva), sertraline (Zoloft), or tranylcypromine (Parnate);\nanti-malaria medication such as chloroquine (Aralen) or pyrimethamine (Daraprim), or quinine (Qualaquin);\nheart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), clonidine (Catapres, Clorpres, Kapvay, Nexiclon), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;\nheart rhythm medicine such as amiodarone (Cordarone, Pacerone), quinidine (Quin-G), procainamide (Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others;\nHIV or AIDS medicine such as delavirdine (Rescriptor) or ritonavir (Norvir, Kaletra); or\nmedicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).\nThis list is not complete and other drugs may interact with Bystolic. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.\n Bystolic drug interactions (more detail)\n','Get emergency medical help if you have any of these signs of an allergic reaction to Bystolic: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:\nfeeling short of breath, even with mild exertion;\nswelling of your ankles or feet;\nslow or uneven heartbeats; or\nnumbness or cold feeling in your hands and feet.\nLess serious Bystolic side effects may include:\nheadache;\ntired feeling;\nnausea, stomach pain;\ndiarrhea; or\nsleep problems (insomnia).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Bystolic side effects (more detail)\n','Bystolic (nebivolol) belongs to a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).\nBystolic is used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack.\nBystolic may also be used for other purposes not listed in this medication guide.\n','Do not skip doses or stop taking Bystolic without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems such as severe chest pain or heart attack. You may need to use less and less before you stop the medication completely. If you need surgery, tell the surgeon ahead of time that you are using Bystolic.\nBystolic may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nBystolic is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.\nKeep using Bystolic as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nBefore taking this medicine\nTo make sure you can safely take Bystolic, tell your doctor if you have any of these other conditions:\nsevere liver disease; or\na heart problem such as heart block, sick sinus syndrome, slow heart rate, or heart failure.\nIf you have any of these other conditions, you may need a Bystolic dose adjustment or special tests:\nasthma, bronchitis, emphysema;\nliver or kidney disease;\ndiabetes;\na thyroid disorder;\na history of allergies;\nproblems with circulation (such as Raynaud\'s syndrome);\npheochromocytoma (tumor of the adrenal gland); or\nif you have recently had a heart attack.\nFDA pregnancy category C. It is not known whether Bystolic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Bystolic. It is not known whether nebivolol passes into breast milk or if it could harm a nursing baby. Do not use Bystolic without telling your doctor if you are breast-feeding a baby.\n Bystolic pregnancy and breastfeeding warnings (more detail)\n','Bystolic may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\n'),(120,'cabometyx','Usual Adult Dose for Renal Cell Carcinoma:\nTablets: 60 mg orally once a day until patient no longer experiences clinical benefit or unacceptable toxicity occurs\nUse: For patients with advanced renal cell carcinoma (RCC)\nUsual Adult Dose for Hepatocellular Carcinoma:\nTablets: 60 mg orally once a day until patient no longer experiences clinical benefit or unacceptable toxicity occurs\nUse: For patients with hepatocellular carcinoma (HCC) who have been previously\ntreated with sorafenib\n Detailed Cabometyx dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nOther drugs may interact with cabozantinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Cabometyx drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Cabometyx: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.\nCall your doctor at once if you have:\nsevere headache, blurred vision, pounding in your neck or ears;\nvomiting, diarrhea, or constipation that are severe and ongoing;\nswelling in your hands, arms, legs, or feet;\neasy bruising or bleeding (nosebleeds, bleeding gums, heavy menstrual bleeding, or any bleeding that will not stop);\nbloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds;\njaundice (yellowing of the skin or eyes);\npain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;\nconfusion, thinking problems, weakness, vision changes, seizure;\na light-headed feeling, like you might pass out;\njaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work;\nlow white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing;\nadrenal gland problems - nausea, vomiting, extreme tiredness, dizziness, weakness, fainting; or\nsigns of a stroke or blood clot - sudden numbness or weakness on one side of your body, problems with vision or balance, trouble speaking or understanding what is said to you, chest pain, trouble breathing, swelling or pain in an arm or leg.\nYour future doses of cabozantinib may be delayed or permanently discontinued if you have certain side effects.\nCommon Cabometyx side effects may include:\nstomach pain, nausea, vomiting, loss of appetite, diarrhea, constipation;\npain, redness, swelling, or sores in your mouth or throat;\ntrouble speaking, changes in taste;\ncold symptoms such as stuffy nose, sneezing, sore throat, cough;\nrash;\npain in your muscles, bones, and joints;\nabnormal liver function tests or other blood tests;\nfeeling tired;\nweight loss; or\nhair color turning lighter.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cabometyx side effects (more detail)\n','Cabometyx (cabozantinib) is a kinase inhibitor, a type of enzyme inhibitor that blocks the action of certain protein kinases.\nCabometyx is used to treat advanced kidney cancer, sometimes in combination with another medicine called nivolumab.\nCabometyx is also used to treat liver cancer (hepatocellular carcinoma) in people who have been previously treated with sorafenib.\n','Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. This medicine can also increase your risk of serious bleeding.\nCall your doctor if you have: severe stomach pain, choking or gagging when you eat or drink, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood.\nBefore taking this medicine\nTo make sure Cabometyx is safe for you, tell your doctor if you have:\nan open wound on your skin (or a wound that is still healing);\nbleeding problems (such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds);\nhigh blood pressure;\nliver disease; or\na pre-existing dental problem.\nYou may need to have a negative pregnancy test before starting this treatment.\nCabozantinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using Cabometyx and for at least 4 months after your last dose. Tell your doctor if you think you might be pregnant.\nCabozantinib may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Cabometyx can harm an unborn baby.\nYou should not breastfeed while using Cabometyx, and for at least 4 months after your last dose.\nHow should I take Cabometyx?\nTake Cabometyx exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nDo not use Cabometyx tablets in place of Cometriq (cabozantinib) capsules. Take only the pill form your doctor has prescribed. Avoid medication errors by always checking the medicine you receive at the pharmacy.\nTake Cabometyx on an empty stomach, at least 1 hour before or 2 hours after you eat anything.\nDo not take Cabometyx with food.\nTake this medicine with a full glass of water.\nDo not crush, chew, or break a tablet, and do not open a capsule. Swallow the pill whole.\nWhen used with Cabometyx, nivolumab is usually given as an infusion into a vein once every 2 to 4 weeks.\nYour blood pressure and liver function may need to be checked often.\nIf you need surgery or dental work, stop taking Cabometyx at least 3 weeks ahead of time. After a surgery or dental procedure, you may need to wait 2 weeks before you start taking Cabometyx again. Follow your doctor\'s dosing instructions very carefully.\nIf you have stopped taking Cabometyx for any reason, talk with your doctor before you start taking it again.\nStore at room temperature away from moisture and heat.\n','Grapefruit may interact with Cabometyx and lead to unwanted side effects. Avoid the use of grapefruit products while taking cabozantinib.\nAvoid taking an herbal supplement containing St. John\'s wort.\n'),(121,'calcitriol','Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nCalcitriol oral is taken by mouth.\nMeasure oral liquid carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nCalcitriol injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.\nRead and carefully follow any Instructions for Use provided with your medicine. Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.\nYou will need frequent medical tests.\nDrink plenty of fluids unless your doctor has told you to restrict your fluid intake.\nYou may need to follow a special diet while using calcitriol. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.\nCall your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking calcitriol. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.\nIf you need major surgery or will be on long-term bed rest, your dose or testing needs may change. Follow your doctor\'s instructions.\nStore at room temperature away from moisture, heat, and light.\n Detailed Calcitriol dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nEarly signs of overdose may include headache, weakness, drowsiness, dry mouth, metallic taste, nausea, vomiting, constipation, stomach pain, loss of appetite, muscle pain, or bone pain.\nLate signs of overdose may include increased thirst, itching, increased urination (especially at night), severe stomach pain spreading to your back, irregular heartbeats, loss of appetite, weight loss, feeling hot, decreased interest in sex, or being unable to urinate.\n','Tell your doctor about all your other medicines, especially:\ncholestyramine;\ndigoxin, digitalis;\nketoconazole;\na diuretic or \"water pill\"--hydrochlorothiazide, HCTZ, Diovan HCT, Hyzaar, Maxzide, Tenoretic, Zestoretic, and others;\nseizure medicine--phenobarbital, phenytoin; or\nsteroid medicine--prednisone, dexamethasone, fluticasone, and others.\nThis list is not complete. Other drugs may affect calcitriol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Calcitriol drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using calcitriol and call your doctor at once if you have:\ndehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;\nhigh calcium levels--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling; or\nlow calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).\nCalcitriol can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using  calcitriol.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Calcitriol side effects (more detail)\n','Calcitriol is a form of vitamin D3. Vitamin D helps your body absorb calcium from the stomach.\nCalcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis.\nCalcitriol is also used to treat calcium deficiency in people with hypoparathyroidism (underactive parathyroid glands) caused by surgery, disease, or other conditions.\nCalcitriol is also used to treat calcium deficiency (hypocalcemia) and metabolic bone disease in people who are receiving dialysis.\nCalcitriol may also be used for purposes not listed in this medication guide.\n','You should not use  calcitriol if you have high levels of calcium or vitamin D in your blood, or if you have ever had an allergic reaction to calcitriol or other forms of vitamin D.\nBefore taking this medicine\nYou should not use calcitriol if:\nyou have high levels of calcium or vitamin D in your blood; or\nyou have had an allergic reaction to calcitriol or other forms of vitamin D.\nTell your doctor about all your medical conditions or allergies.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nYou should not breastfeed while using calcitriol.\nDo not give this medicine to a child without medical advice.\n','Do not take other vitamin or mineral supplements unless your doctor has told you to.\nAsk your doctor before using an antacid or laxative, especially if you are on dialysis. Taking antacids or laxatives that contain magnesium may increase your blood levels of magnesium, which could affect your heart or blood pressure.\n'),(122,'calcium-carbonate','Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.\nCheck the label of your calcium carbonate product to see if it should be taken with or without food.\nSwallow the calcium carbonate regular tablet with a full glass of water.\nThe chewable tablet should be chewed before you swallow it.\nShake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nUse the calcium carbonate powder as directed. Allow the powder to dissolve completely, then consume the mixture.\nCalcium carbonate may be only part of a complete program of treatment that also includes dietary changes. Learn about the foods that contain calcium.\nYour calcium carbonate dose may need to be adjusted as you make changes to your diet. Follow your doctor\'s instructions very closely.\nStore at room temperature away from moisture and heat. Do not freeze.\n Detailed Calcium carbonate dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n',NULL,'Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nlittle or no urinating;\nswelling, rapid weight gain; or\nhigh levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or feeling tired.\nCommon side effects may include:\nupset stomach, gas; or\nconstipation.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Calcium carbonate side effects (more detail)\nWhat other drugs can affect calcium carbonate?\nCalcium can make it harder for your body to absorb certain medicines. If you take other medications, take them at least 2 hours before or 4 or 6 hours after you take calcium carbonate.\nOther drugs may interact with calcium carbonate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n','Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of the body, especially bone formation and maintenance.\nCalcium carbonate is used to prevent or to treat a calcium deficiency.\nThere are many brands and forms of calcium carbonate available. Not all brands are listed on this leaflet.\nCalcium carbonate may also be used for purposes not listed in this medication guide.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\n','Ask a doctor or pharmacist before taking any multivitamins, mineral supplements, or antacids while you are taking calcium carbonate.\n'),(123,'calquence','Usual Adult Dose for Mantle Cell Lymphoma:\n100 mg orally approximately every 12 hours\nDuration of Therapy: Until disease progression or unacceptable toxicity\nUse: Treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.\nUsual Adult Dose for Leukemia :\nMonotherapy:\n100 mg orally every 12 hours until disease progression or unacceptable toxicity\nIn Combination With Obinutuzumab:\n100 mg orally every 12 hours until disease progression or unacceptable toxicity; start this drug at Cycle 1 (each cycle is 28 days); start obinutuzumab at Cycle 2 for a total of 6 cycles and refer to the obinutuzumab prescribing information for recommended dosing; administer this drug prior to obinutuzumab when given on the same day\nUse: For the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)\n Detailed Calquence dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. If you are more than 3 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Many drugs can interact with acalabrutinib. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:\nwarfarin (Coumadin, Jantoven);\nan antibiotic or antifungal medicine;\nantiviral medicine to treat hepatitis C or HIV/AIDS;\nheart medication; or\na stomach acid reducer - such as omeprazole, lansoprazole Nexium, Prevacid, Prilosec, Protonix, and others.\nThis list is not complete and many other drugs can interact with acalabrutinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.\n Calquence drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Calquence: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nunusual bleeding (nose, mouth, vagina, or rectum), or any bleeding that will not stop;\nsigns of bleeding inside your body - dizziness, weakness, confusion, problems with speech, prolonged headache, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds;\nheart rhythm problems - chest pain, shortness of breath, pounding heartbeats or fluttering in your chest, feeling light-headed;\nlow red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;\nsigns of infection - fever, chills, tiredness, flu-like symptoms, cough with mucus, chest pain, trouble breathing; or\nsigns of a serious brain infection - any change in your mental state, decreased vision, weakness on one side of your body, or problems with walking (may start gradually and get worse quickly).\nYour cancer treatments may be delayed or permanently discontinued if you have certain side effects.\nCommon Calquence side effects may include:\nbruising;\nheadache;\nmuscle pain;\ndiarrhea; or\nfeeling tired.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Calquence side effects (more detail)\n','Calquence (acalabrutinib) blocks the action of certain enzymes in the body, which can interfere with the growth and spread of cancer cells.\nCalquence is used to treat mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults. This medicine is given after other treatments have failed.\nCalquence was approved by the US Food and Drug Administration (FDA) on an \"accelerated\" basis. In clinical studies, patients responded to this medicine. However, further studies are needed.\nCalquence is also used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults.\n','Calquence can make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.\nCall your doctor at once if you have signs of bleeding inside your body, such as: dizziness, weakness, confusion, headache, speech problems, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds.\nBefore taking this medicine\nYou should not use Calquence if you are allergic to acalabrutinib.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\nan active or chronic infection;\na heart rhythm disorder;\nbleeding problems; or\nhepatitis B (acalabrutinib can cause this condition to come back or get worse).\nTaking Calquence may increase your risk of developing other types of cancer, such as skin cancer. Talk to your doctor about this risk and what skin symptoms to watch for.\nIt is not known whether acalabrutinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether acalabrutinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Calquence, and for at least 2 weeks after your last dose.\nHow should I take Calquence?\nTake Calquence exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nCalquence is usually taken once every 12 hours until your body no longer responds to the medicine.\nTake this medicine with a full glass of water.\nYou may take this medicine with or without food.\nDo not chew, break, or open the Calquence capsule. Swallow the capsule whole.\nIf you need surgery, tell the surgeon ahead of time that you are using acalabrutinib. You may need to stop using the medicine for a short time.\nWhile using Calquence, you may need frequent blood tests.\nStore at room temperature away from moisture and heat.\n','If you also take an antacid or stomach acid reducer (such as Zantac), take your Calquence dose at least 2 hours before you take the stomach medicine.\nAvoid exposure to sunlight or tanning beds. Acalabrutinib can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.\n'),(124,'caplyta','Usual Adult Dose for Schizophrenia:\n42 mg orally once a day\nComments:\n-Dose titration is not necessary.\n-This drug should be taken with food.\nUse: Treatment of schizophrenia\n Detailed Caplyta dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nTell your doctor about all your current medicines. Many drugs can affect Caplyta, especially:\nan antibiotic, antifungal, or antiviral medicine;\nblood pressure medication;\nbronchodilator asthma medication;\ncold or allergy medicine (Benadryl and others);\nmedicine to treat depression, anxiety, mood disorders, or mental illness;\nmedicine to treat overactive bladder;\nmedicine to treat Parkinson\'s disease;\nmedicine to treat stomach problems, motion sickness, or irritable bowel syndrome;\nseizure medicine; or\nSt. John\'s wort.\nThis list is not complete and many Other drugs may interact with lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Caplyta drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Caplyta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nHigh doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use Caplyta, the more likely you are to develop this disorder, especially if you are a woman or an older adult.\nCall your doctor at once if you have:\nfeeling unsteady, feeling like you might pass out;\nuncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);\ntightness in your neck or throat, trouble swallowing;\ntrouble breathing or speaking;\na seizure;\nhigh blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;\nlow white blood cell counts - fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or\nsevere nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.\nCommon Caplyta side effects may include:\nweight gain;\ndrowsiness; or\ndry mouth.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Caplyta side effects (more detail)\n','Caplyta capsules contain lumateperone, an antipsychotic medicine.\nCaplyta is a once-daily capsule used to control the symptoms of schizophrenia in adults.\nAlthough the physical cause of schizophrenia is unknown, it is believed that imbalances between chemicals, such as dopamine, serotonin, and glutamate, in the brain is the probable cause. The exact way Caplyta works is unknown but it is thought to affect the balance of these brain-signaling chemicals to help control schizophrenia symptoms.\n','Caplyta is not approved for use in older adults with dementia-related psychosis. Caplyta can increase the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).\nBefore taking this medicine\nYou should not use Caplyta if you are allergic to lumateperone.\nCaplyta may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.\nTo make sure Caplyta is safe for you, tell your doctor if you have ever had:\ntrouble swallowing;\nhigh cholesterol or triglycerides;\ndiabetes; or\nliver disease.\nTaking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking Caplyta without your doctor\'s advice.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.\nYou should not breastfeed while using Caplyta.\nCaplyta may affect fertility (your ability to have children), whether you are a man or a woman.\nCaplyta is not approved for use by anyone younger than 18 years old.\nHow should I take Caplyta?\nTake Caplyta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nTake with food.\nYou will need frequent medical tests.\nSome things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you are sick with vomiting or diarrhea.\nStore at room temperature away from moisture and heat.\n','While you are taking Caplyta, you may be more sensitive to very hot conditions. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise.\nAvoid driving or hazardous activity until you know how lumateperone will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.\nGrapefruit may interact with lumateperone and lead to unwanted side effects. Avoid the use of grapefruit products.\n'),(125,'captopril','Take captopril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nCaptopril is usually taken 1 hour before meals. Follow your doctor\'s instructions.\nCall your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking captopril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.\nDrink plenty of water each day while you are taking captopril.\nYour blood pressure will need to be checked often, and you may need frequent blood tests.\nThis medication can cause false results with certain medical tests. Tell any doctor who treats you that you are using captopril.\nIf you need surgery, tell the surgeon ahead of time that you are using captopril. You may need to stop using the medicine for a short time.\nIf you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.\nStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.\n Detailed Captopril dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with captopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Captopril drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to captopril: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nlittle or no urination, or urinating more than usual;\nshortness of breath (even with mild exertion), swelling, rapid weight gain;\nchest pain or pressure, pounding heartbeats or fluttering in your chest;\nhigh potassium - nausea, slow or unusual heart rate, weakness, loss of movement; or\nsudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms.\nCommon captopril side effects may include:\ncough;\nflushing (warmth, redness, or tingly feeling);\nnumbness, tingling, or burning pain in your hands or feet;\nloss of taste sensation; or\nmild skin itching or rash.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Captopril side effects (more detail)\n','Captopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.\nCaptopril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack.\nCaptopril may also be used for purposes not listed in this medication guide.\n','Do not use captopril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.\nIf you have diabetes, do not use captopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).\nBefore taking this medicine\nYou should not use this medicine if you are allergic to captopril or to any other ACE inhibitor, such as benazepril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.\nYou may also need to avoid taking captopril with aliskiren if you have kidney disease.\nTo make sure captopril is safe for you, tell your doctor if you have:\nkidney disease (or if you are on dialysis);\nliver disease;\ndiabetes;\na connective tissue disease such as Marfan syndrome, Sjogren\'s syndrome, lupus, scleroderma, or rheumatoid arthritis; or\nif you have had an organ transplant.\nDo not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Captopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.\nCaptopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using captopril.\n','Drinking alcohol can further lower your blood pressure and may increase certain side effects of captopril.\nDo not use salt substitutes or potassium supplements while taking captopril, unless your doctor has told you to.\nAvoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor\'s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.\nAvoid strenuous exercise without your doctor\'s approval if you are being treated for heart failure.\n'),(126,'carafate','Usual Adult Dose for Duodenal Ulcer:\n1 g orally 4 times a day\n-Duration of therapy: 4 to 8 weeks\nComments:\n-Each dose should be taken on an empty stomach.\n-For most patients, treatment should continue for 4 to 8 weeks; however, treatment may be stopped early if healing is demonstrated on x-ray/endoscopic tests.\n-Antacids may be given, but use should be separated by at least 30 minutes.\nUse: Short-term treatment of active duodenal ulcers\nUsual Adult Dose for Duodenal Ulcer Prophylaxis:\nOral Tablets: 1 g orally 2 times a day\n-Duration of therapy: Up to 1 year\nComments:\n-Each dose should be taken on an empty stomach.\n-Controlled studies did not extend beyond 12 months.\nUse: Maintenance therapy for patients after healing of acute duodenal ulcers\n Detailed Carafate dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with sucralfate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Carafate drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Carafate: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCommon Carafate side effects may include:\nconstipation, diarrhea;\nnausea, vomiting, gas, indigestion;\nitching, rash;\ndizziness, drowsiness;\nsleep problems (insomnia);\nheadache; or\nback pain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Carafate side effects (more detail)\n','Carafate (sucralfate) is an anti-ulcer medication.\nCarafate is not greatly absorbed into the body through the digestive tract. It works mainly in the lining of the stomach by sticking to ulcer sites and protecting them from acids, enzymes, and bile salts.\nCarafate is used to treat an active duodenal ulcer. Sucralfate can heal an active ulcer, but it will not prevent future ulcers from occurring.\n','The liquid form of Carafate should never be injected through a needle into the body, or death may occur.\nFollow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nAvoid taking any other medications within 2 hours before or after you take Carafate. Sucralfate can make it harder for your body to absorb other medications you take by mouth.\nBefore taking this medicine\nYou should not use Carafate if you are allergic to sucralfate.\nTo make sure this medicine is safe for you, tell your doctor if you have:\ndiabetes;\nkidney disease (or if you are on dialysis); or\ntrouble swallowing tablets.\n>Older adults may be more sensitive to the effects of sucralfate.\nTell your doctor if you are pregnant or breastfeeding.\nDo not give Carafate to a child without medical advice.\nHow should I take Carafate?\nTake Carafate exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nTake this medicine on an empty stomach.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nIf you are diabetic, check your blood sugar regularly. Your doctor may adjust your dose based on your blood sugar levels.\nThe liquid form of this medicine should never be injected through a needle into the body, or death may occur. Carafate oral suspension is to be taken only by mouth.\nIt may take 2 to 8 weeks before you receive the full benefit of taking Carafate. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.\nYour doctor may want you to keep taking Carafate at a lower dose once your active ulcer has healed. Follow your doctor\'s dosing instructions very carefully.\nStore at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.\n','Avoid taking any other medications within 2 hours before or after you take Carafate. Sucralfate can make it harder for your body to absorb other medications you take by mouth.\nAsk your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for sucralfate to work in your stomach. Avoid taking an antacid within 30 minutes before or after taking Carafate.\n'),(127,'carbamazepine','Take carbamazepine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.\nTake with food.\nSwallow the extended-release tablet or capsule whole and do not crush, chew, or break it. Tell your doctor if you cannot swallow a pill whole.\nThe chewable tablet must be chewed before you swallow it.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nIt may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and call your doctor promptly if this medicine seems to stop working as well in preventing your seizures.\nYou will need frequent medical tests.\nStore at room temperature away from moisture, heat, and light.\nDo not stop using carbamazepine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor\'s instructions about tapering your dose.\n Detailed Carbamazepine dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include severe drowsiness, weak or shallow breathing, and loss of consciousness.\n','Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.\nUsing carbamazepine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.\nMany drugs can interact with carbamazepine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Carbamazepine drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to carbamazepine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).\nSeek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.\nReport any new or worsening symptoms to your doctor, such as: sudden mood or behavior changes, depression, anxiety, insomnia, or if you feel agitated, hostile, restless, irritable, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\na skin rash, no matter how mild;\nloss of appetite, right-sided upper stomach pain, dark urine;\nslow, fast, or pounding heartbeats;\nanemia or other blood problems - fever, chills, sore throat, mouth sores, bleeding gums, nosebleeds, pale skin, easy bruising, unusual tiredness, feeling light-headed or short of breath; or\nlow levels of sodium in the body - headache, confusion, severe weakness, feeling unsteady, increased seizures.\nCommon carbamazepine side effects may include:\ndizziness, loss of coordination, problems with walking;\nnausea, vomiting; or\ndrowsiness.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Carbamazepine side effects (more detail)\n','Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy.\nCarbamazepine is also used to treat bipolar disorder.\nCarbamazepine may also be used for purposes not listed in this medication guide.\n','You should not take carbamazepine if you have a history of bone marrow suppression, if you are allergic to it, or take an antidepressant such as amitriptyline, desipramine, doxepin, imipramine, or nortriptyline.\nTELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE. Some drugs can raise or lower your blood levels of carbamazepine, which may cause side effects or make this medicine less effective. Carbamazepine can also affect blood levels of certain other drugs, making them less effective or increasing side effects.\nCarbamazepine may cause serious blood problems or a life-threatening skin rash or allergic reaction. Call your doctor if you have a fever, unusual weakness, bleeding, bruising, or a skin rash that causes blistering and peeling.\nSome people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nDo not stop taking this medicine without asking your doctor first, even if you feel fine.\nIf you are pregnant, do not start or stop taking carbamazepine without your doctor\'s advice.\nBefore taking this medicine\nYou should not take carbamazepine if you have a history of bone marrow suppression, or if you are allergic to carbamazepine or to an antidepressant such as amitriptyline, desipramine, doxepin, imipramine, or nortriptyline.\nDo not use carbamazepine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.\nCarbamazepine may cause severe or life-threatening skin rash, and especially in people of Asian ancestry. Your doctor may recommend a blood test before you start the medication to determine your risk.\nTell your doctor if you have ever had:\nheart problems;\nliver or kidney disease;\nglaucoma;\nporphyria;\nlow sodium levels;\ndepression, mood disorder; or\nsuicidal thoughts or actions.\nYou may have thoughts about suicide while taking carbamazepine. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nDo not start or stop taking seizure medication during pregnancy without your doctor\'s advice. Carbamazepine may harm an unborn baby, but having a seizure during pregnancy could harm both mother and baby. The benefit of preventing seizures may outweigh any risks to the baby.\nTell your doctor right away if you become pregnant.\nIf you are pregnant, your name may be listed on a pregnancy registry to track the effects of this medicine on the baby.\nCarbamazepine can make birth control pills or implants less effective. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy.\nYou should not breastfeed while you are using carbamazepine.\n','Drinking alcohol with this medicine can cause side effects, and can also increase your risk of seizures.\nGrapefruit may interact with carbamazepine and lead to unwanted side effects. Avoid the use of grapefruit products.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.\nCarbamazepine could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.\n'),(128,'carbidopa-and-levodopa','If you already take levodopa, you must stop taking it at least 12 hours before you start taking carbidopa and levodopa.\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nTake  carbidopa and levodopa at regular intervals, with or without food.\nSwallow the capsule whole and do not crush, chew, break, or open it.\nThe tablet is sometimes broken in half to give the correct dose. Always swallow a whole or half tablet without chewing or crushing.\nPlace the orally disintegrating tablet in your mouth and allow it to dissolve, without chewing.\nIt may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if the effects of this medicine wear off quickly between doses.\nIf you use this medicine long-term, you may need frequent medical tests.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using carbidopa and levodopa.\nDo not stop using carbidopa and levodopa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.\nStore at room temperature away from moisture, heat, and light.\n Detailed Carbidopa/levodopa dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nGet your prescription refilled before you run out of medicine completely.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may affect carbidopa and levodopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Carbidopa/levodopa drug interactions (more detail)\nDoes Carbidopa/levodopa interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nuncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);\nworsening of tremors (uncontrolled shaking);\nsevere or ongoing vomiting or diarrhea;\nconfusion, hallucinations, unusual changes in mood or behavior;\ndepression or suicidal thoughts; or\nsevere nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.\nSome people taking carbidopa and levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.\nYou may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.\nYou may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.\nCommon side effects may include:\njerky or twisting muscle movements;\nheadache, dizziness;\nlow blood pressure (feeling light-headed);\nsleep problems, strange dreams;\ndry mouth;\nmuscle contractions; or\nnausea, vomiting, constipation.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Carbidopa/levodopa side effects (more detail)\n','Carbidopa and levodopa is a combination medicine used to treat symptoms of Parkinson\'s disease, such as stiffness or tremors.\nCarbidopa and levodopa is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication.\nCarbidopa and levodopa may also be used for purposes not listed in this medication guide.\n','Do not use  carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to carbidopa or levodopa, or if you have:\nnarrow-angle glaucoma.\nDo not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.\nTell your doctor if you have ever had:\nheart disease, high blood pressure, or heart attack;\nliver or kidney disease;\nan endocrine (hormonal) disorder;\nasthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;\na stomach or intestinal ulcer;\nopen-angle glaucoma; or\ndepression, mental illness, or psychosis.\nThe disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).\nPeople with Parkinson\'s disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.\nTell your doctor if you are pregnant or breastfeeding.\n','Avoid driving or hazardous activity until you know how  carbidopa and levodopa will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nAvoid taking iron supplements or eating a diet high in protein. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or dietitian about the best foods to eat or avoid.\n'),(129,'carvedilol','Take carvedilol exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nCarvedilol works best if you take it with food.\nYou may open the carvedilol capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule.\nTake carvedilol at the same time every day. Do not skip doses or stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.\nIf you are switched from carvedilol tablets to carvedilol extended-release capsules (Coreg CR), your daily total dose of this medicine may be higher or lower than before. Older adults may be more likely to become dizzy or feel faint when switching from tablets to extended-release capsules. Follow your doctor\'s instructions.\nYour blood pressure will need to be checked often.\nIf you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nIf you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time.\nYou should not stop using carvedilol suddenly. Stopping suddenly may make your condition worse.\nCarvedilol can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using carvedilol before surgery unless your surgeon tells you to.\nCarvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.\nStore at room temperature away from moisture and heat.\n Detailed Carvedilol dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, and seizure (convulsions).\n','Other drugs may interact with carvedilol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Carvedilol drug interactions (more detail)\n','Get emergency medical help if you have any of these signs of an allergic reaction to carvedilol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have a serious side effect such as:\na light-headed feeling, like you might pass out;\nslow or uneven heartbeats;\nswelling, rapid weight gain, feeling short of breath (even with mild exertion);\ncold feeling or numbness in your fingers or toes;\nchest pain, dry cough, wheezing, chest tightness, trouble breathing; or\nhigh blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss).\nCommon carvedilol side effects may include:\nweakness, dizziness;\ndiarrhea;\ndry eyes;\ntired feeling; or\nweight gain.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Carvedilol side effects (more detail)\n','Carvedilol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).\nCarvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used after a heart attack that has caused your heart not to pump as well.\nCarvedilol may also be used for purposes not listed in this medication guide.\n','You should not take carvedilol if you have asthma, bronchitis, emphysema, severe liver disease, or a serious heart condition such as heart block, \"sick sinus syndrome,\" or slow heart rate (unless you have a pacemaker).\nAvoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR). Also avoid taking medicines or other products that might contain alcohol. Alcohol may cause the carvedilol in Coreg CR to be released too quickly into the body.\nIf you are being treated for high blood pressure, keep using carvedilol even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.\nBefore taking this medicine\nYou should not take carvedilol if you are allergic to it, or if you have:\nasthma, bronchitis, emphysema;\nsevere liver disease; or\na serious heart condition such as heart block, \"sick sinus syndrome,\" or slow heart rate (unless you have a pacemaker).\nTo make sure carvedilol is safe for you, tell your doctor if you have:\ndiabetes (taking carvedilol can make it harder for you to tell when you have low blood sugar);\nangina (chest pain);\nliver or kidney disease;\na thyroid disorder;\npheochromocytoma (tumor of the adrenal gland);\ncirculation problems (such as Raynaud\'s syndrome); or\na history of allergies.\nFDA pregnancy category C. It is not known whether carvedilol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.\nIt is not known whether carvedilol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking carvedilol.\n Carvedilol pregnancy and breastfeeding warnings (more detail)\n','Carvedilol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\nDrinking alcohol can further lower your blood pressure and may increase certain side effects of carvedilol. You should especially avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol (Coreg CR).\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.\n'),(130,'cefdinir','Usual Adult Dose for Pneumonia:\nCommunity acquired: 300 mg orally every 12 hours for 10 to 14 days\nUsual Adult Dose for Bronchitis:\nAcute exacerbations of chronic bronchitis: 300 mg orally every 12 hours for 5 to 10 days or 600 mg orally every 24 hours for 10 days\nUsual Adult Dose for Sinusitis:\nAcute maxillary sinusitis: 300 mg orally every 12 hours or 600 mg orally every 24 hours for 10 days\nUsual Adult Dose for Skin or Soft Tissue Infection:\nUncomplicated: 300 mg orally every 12 hours for 10 days\nUsual Adult Dose for Tonsillitis/Pharyngitis:\n300 mg orally every 12 hours for 5 to 10 days or 600 mg orally every 24 hours for 10 days\nUsual Pediatric Dose for Pneumonia:\nCommunity acquired:13 years or older: 300 mg orally every 12 hours for 10 to 14 days\nUsual Pediatric Dose for Bronchitis:\nAcute exacerbations of chronic bronchitis:13 years or older: 300 mg orally every 12 hours for 5 to 10 days or 600 mg orally every 24 hours for 10 days\nUsual Pediatric Dose for Otitis Media:\nAcute bacterial otitis media:6 months through 12 years: 7 mg/kg orally every 12 hours for 5 to 10 days or 14 mg/kg orally every 24 hours for 10 daysMaximum dose: 600 mg/day\nUsual Pediatric Dose for Tonsillitis/Pharyngitis:\n6 months through 12 years: 7 mg/kg orally every 12 hours for 5 to 10 days or 14 mg/kg orally every 24 hours for 10 daysMaximum dose: 600 mg/day13 years or older: 300 mg orally every 12 hours for 5 to 10 days or 600 mg orally every 24 hours for 10 days\nUsual Pediatric Dose for Sinusitis:\nAcute maxillary sinusitis:6 months through 12 years: 7 mg/kg orally every 12 hours or 14 mg/kg orally every 24 hours for 10 daysMaximum dose: 600 mg/day13 years or older: 300 mg orally every 12 hours or 600 mg orally every 24 hours for 10 days\nUsual Pediatric Dose for Skin and Structure Infection:\nUncomplicated:6 months through 12 years: 7 mg/kg orally every 12 hours for 10 daysMaximum dose: 600 mg/day13 years or older: 300 mg orally every 12 hours for 10 days\n Detailed Cefdinir dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\n','Tell your doctor about all your other medicines, especially:\nprobenecid; or\nvitamin or mineral supplements that contain iron.\nThis list is not complete. Other drugs may affect cefdinir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Cefdinir drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nCall your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);\nfever, chills, body aches, flu symptoms;\npale skin, easy bruising, unusual bleeding;\nseizure (convulsions);\nfever, weakness, confusion;\ndark colored urine, jaundice (yellowing of the skin or eyes); or\nkidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath.\nCommon side effects may include:\nnausea, vomiting, stomach pain, diarrhea;\nvaginal itching or discharge;\nheadache; or\nrash (including diaper rash in an infant taking liquid cefdinir.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cefdinir side effects (more detail)\n','Cefdinir is a cephalosporin (SEF a low spor in) antibiotic that is used to treat many different types of infections caused by bacteria.\nCefdinir may also be used for purposes not listed in this medication guide.\n','Do not take  cefdinir if you are allergic to cefdinir, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, and others.\nBefore taking this medicine\nYou should not take this medicine if you are allergic to cefdinir or any other cephalosporin antibiotic (cefadroxil, cefprozil, cefazolin, cefalexin, Keflex, and others).\nTell your doctor if you have ever had:\nkidney disease (or if you are on dialysis);\nintestinal problems, such as colitis; or\nan allergy to any drugs (especially penicillins).\nCefdinir liquid contains sucrose. Talk to your doctor before using this form of cefdinir if you have diabetes.\nTell your doctor if you are pregnant or breastfeeding.\nHow should I take cefdinir?\nFollow all directions on your prescription label and read all medicine guides or instruction sheets. Use the medicine exactly as directed.\nShake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nYou may take cefdinir with or without food.\nUse  cefdinir for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Cefdinir will not treat a viral infection such as the flu or a common cold.\nCefdinir can affect the results of certain medical tests. Tell any doctor who treats you that you are using cefdinir.\nStore at room temperature away from moisture and heat. Throw away any unused cefdinir liquid that is older than 10 days.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, vomiting, stomach pain, diarrhea, or a seizure.\n','Avoid using antacids or mineral supplements that contain aluminum, magnesium, or iron within 2 hours before or after taking cefdinir. Antacids or iron can make it harder for your body to absorb cefdinir. This does not include baby formula fortified with iron.\nAntibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\n'),(131,'cefixime','Follow all directions on your prescription label. Do not take  cefixime in larger or smaller amounts or for longer than recommended.\nYou may take cefixime with or without food.\nThe cefixime chewable tablet must be chewed before you swallow it.\nShake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nThis medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using cefixime.\nUse this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefixime will not treat a viral infection such as the common cold or flu.\nStore at room temperature away from moisture, heat, and light.\nYou may also store the oral liquid in the refrigerator. Throw away any unused liquid after 14 days.\n Detailed Cefixime dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Other drugs may interact with cefixime, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.\n Cefixime drug interactions (more detail)\nDoes Cefixime interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\njaundice (yellowing of the skin or eyes);\npale or yellowed skin, dark colored urine, confusion or weakness;\na seizure (convulsions);\nlow blood cell counts--sudden weakness or ill feeling, fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;\nkidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or\nsevere skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.\nCommon side effects may include:\nindigestion, stomach pain;\nnausea, vomiting; or\nvaginal itching or discharge.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cefixime side effects (more detail)\n','Cefixime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.\nCefixime is used to treat many different types of infections caused by bacteria.\nCefixime may also be used for purposes not listed in this medication guide.\n','You should not take  cefixime if you are allergic to cefixime, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others. Tell your doctor if you are allergic to penicillins.\nBefore taking this medicine\nYou should not take this medicine if you are allergic to cefixime or to other cephalosporin antibiotics, such as:\ncefaclor (Raniclor);\ncefadroxil (Duricef);\ncefazolin (Ancef);\ncefdinir (Omnicef);\ncefditoren (Spectracef);\ncefpodoxime (Vantin);\ncefprozil (Cefzil);\nceftibuten (Cedax);\ncefuroxime (Ceftin);\ncephalexin (Keflex);\ncephradine (Velosef); and others.\nTo make sure cefixime is safe for you, tell your doctor if you are allergic to any drugs, especially penicillins.\nThe chewable tablet form may contain phenylalanine. Talk to your doctor before using this form of cefixime if you have phenylketonuria (PKU).\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.\nIt is not known whether cefixime passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding. You may need to stop nursing while you are taking cefixime.\nThe cefixime suspension (liquid) contains sucrose. Talk to your doctor before using this form of cefixime if you have diabetes.\n','Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.\n'),(132,'ceftriaxone',NULL,NULL,NULL,NULL,NULL,NULL),(133,'cefuroxime','Take cefuroxime only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.\nCeftin® oral liquid works differently than Ceftin® tablets, even at the same dose (number of milligrams). Do not switch from the tablets to the oral liquid unless your doctor tells you to.\nThe oral liquid form must be taken with meals, while the tablet form may be given with or without food.\nSwallow the tablets whole. Do not break, crush, or chew it.\nShake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.\nKeep using cefuroxime for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.\nDosing\nThe dose of cefuroxime will be different for different patients. Follow your doctor\'s orders or the directions on the label. The following information includes only the average doses of cefuroxime. If your dose is different, do not change it unless your doctor tells you to do so.\nThe amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.\nFor infections:\nFor oral dosage form (film-coated tablets):\nAdults and teenagers—250 to 500 milligrams (mg) two times a day for 10 days. Gonorrhea is treated with a single 1-gram (g) dose.\nChildren (who can swallow the tablets)—250 mg two times a day for 10 days.\nChildren (who cannot swallow the tablets)—Use is not recommended.\nFor oral dosage form (suspension):\nChildren 3 months to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 30 milligrams (mg) per kilogram (kg) of body weight per day divided into two doses, taken for 10 days. However, the dose is usually not more than 1000 mg.\nInfants up to 3 months—Use and dose must be determined by your doctor.\nMissed dose\nIf you miss a dose of cefuroxime, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.\nStorage\nKeep out of the reach of children.\nDo not keep outdated medicine or medicine no longer needed.\nAsk your healthcare professional how you should dispose of any medicine you do not use.\nStore the oral liquid in the refrigerator. Throw away any unused medicine after 10 days.\nStore the tablets in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.\n Detailed Cefuroxime dosage information\n',NULL,'Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\nCheck with your doctor immediately if any of the following side effects occur:\nMore common\nChills\ndiarrhea\nfever\ngeneral feeling of illness or discomfort\nheadache\nitching of the vagina or genital area\npain during sexual intercourse\nrigidity\nsweating\nthick, white vaginal discharge with no odor or with a mild odor\nLess common\nBlack, tarry stools\nchest pain\ncough\nloose stools\npainful or difficult urination\nshortness of breath\nsore throat\nsores, ulcers, or white spots on the lips or in the mouth\nswollen glands\nunusual bleeding or bruising\nunusual tiredness or weakness\nRare\nBack, leg, or stomach pains\nbladder pain\nbleeding gums\nbloody or cloudy urine\nbody aches or pain\nburning while urinating\ndark urine\ndifficulty with breathing\near congestion\nfast, pounding, or irregular heartbeat or pulse\nfrequent urge to urinate\ngeneral body swelling\nloss of appetite\nloss of voice\nlower back or side pain\nnasal congestion\nnausea or vomiting\nnosebleeds\npain or tenderness around the eyes and cheekbones\npale skin\npink or red urine\nsneezing\nstuffy or runny nose\nswelling of the joints\nswollen glands\ntightness of chest or wheezing\nwhite or brownish vaginal discharge\nwhite patches in the mouth or throat or on the tongue\nwhite patches with diaper rash\nyellowing of the eyes or skin\nIncidence not known\nBlistering, peeling, or loosening of the skin\nbloody, black, or tarry stools\nclay-colored stools\ncough or hoarseness\ncoughing up blood\ndecrease in urine output or decrease in urine-concentrating ability\nfeeling of discomfort\nfever with or without chills\ngeneral feeling of tiredness or weakness\nhigh fever\nhives\nincreased menstrual flow or vaginal bleeding\njoint or muscle pain\nlarge, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs\nlight-colored stools\nparalysis\nprolonged bleeding from cuts\npuffiness or swelling of the eyelids or around the eyes, face, lips, or tongue\nred or black, tarry stools\nred or dark brown urine\nred skin lesions, often with a purple center\nred, irritated eyes\nseizures\nswollen lymph glands\nswollen or painful glands\nunpleasant breath odor\nupper right abdominal or stomach pain\nvomiting of blood\nSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:\nLess common\nBad, unusual, or unpleasant (after) taste\nchange in taste\ndiaper rash\nRare\nAbdominal or stomach cramps\nacid or sour stomach\nbelching\nbloated\ndifficulty with moving\nexcess air or gas in the stomach or intestines\nflushing or redness of the skin\nfull feeling\ngas in the stomach\nheartburn\nindigestion\nirritability\nirritation or soreness of the mouth\nitching skin\nmuscle pain or stiffness\nmuscle spasm of the neck\npassing gas\nrestlessness\nsleepiness or unusual drowsiness\nstomach discomfort, upset, or pain\nswelling of the tongue\nthirst\ntrouble sitting still\nunusually warm skin\nwatering of the mouth and drooling\nweight loss\nIncidence not known\nHives or welts\nredness of the skin\nOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.\nCall your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.\n Cefuroxime side effects (more detail)\n','Cefuroxime is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, cefuroxime will not work for colds, flu, or other virus infections.\nCefuroxime is available only with your doctor\'s prescription.\n','If your symptoms do not improve within a few days, or if they become worse, check with your doctor.\nCefuroxime may cause diarrhea, and in some cases it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.\nBefore you or your child have any medical tests, tell the medical doctor in charge that you are using cefuroxime. The results of some tests may be affected by cefuroxime.\n',NULL),(134,'celebrex','Usual Adult Dose for Pain:\nAcute pain: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.\nUsual Adult Dose for Dysmenorrhea:\n400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.\nUsual Adult Dose for Osteoarthritis:\n200 mg orally once daily or 100 mg orally twice daily.\nUsual Adult Dose for Rheumatoid Arthritis:\n100 to 200 mg orally twice daily.\nUsual Adult Dose for Familial Adenomatous Polyposis:\n400 mg orally twice daily with food.\nUsual Adult Dose for Ankylosing Spondylitis:\n200 mg orally once daily or 100 mg orally twice daily. If after 6 weeks of therapy no results are observed, a trial dose of 400 mg orally daily may be worthwhile. If no response is seen after 6 weeks, consideration should be given to alternate treatment options.\nUsual Pediatric Dose for Juvenile Rheumatoid Arthritis:\n2 years or older:\n10 to less than or equal to 25 kg: 50 mg orally twice daily\nGreater than 25 kg: 100 mg orally twice daily\n Detailed Celebrex dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Ask your doctor before using Celebrex if you take an antidepressant, steroid medicine, or medicine to treat or prevent blood clots. Taking certain medicines with an NSAID may increase your risk of a stomach ulcer or bleeding.\nMany drugs can interact with celecoxib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Celebrex drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Celebrex (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nGet emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.\nStop using Celebrex and call your doctor at once if you have:\nthe first sign of any skin rash, no matter how mild;\nheart problems - swelling, rapid weight gain, feeling short of breath;\nsigns of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;\nliver problems - nausea, stomach pain (upper right side), itching, tiredness, dark urine, jaundice (yellowing of the skin or eyes);\nkidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or\nlow red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.\nCommon Celebrex side effects may include:\nstomach pain, heartburn, gas, diarrhea, constipation, nausea, vomiting;\nswelling in your hands or feet;\ndizziness; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Celebrex side effects (more detail)\n','Celebrex (celecoxib) is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.\nCelebrex is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.\nCelebrex is used to treat juvenile rheumatoid arthritis in children who are at least 2 years old. It is also used in the treatment of hereditary polyps in the colon.\n','Celebrex may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults. You should not take this medicine if you already have bleeding in your stomach or intestines.\nCelecoxib can increase your risk of fatal heart attack or stroke, even if you don\'t have any risk factors. Do not use Celebrex just before or after heart bypass surgery (coronary artery bypass graft, or CABG).\nBefore taking this medicine\nYou should not use Celebrex if you are allergic to celecoxib, or if you have:\nan allergy to sulfa drugs; or\na history of asthma attack or severe allergic reaction after taking aspirin or an NSAID.\nTo make sure this medicine is safe for you, tell your doctor if you have ever had:\na stomach ulcer, bleeding in your stomach or intestines;\nheart disease, high blood pressure;\nasthma;\nbleeding problems;\nliver or kidney disease; or\nif you smoke or drink alcohol.\nIf you are pregnant, you should not take Celebrex unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.\nIt may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.\nHow should I take Celebrex?\nTake Celebrex exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.\nYou may take Celebrex with or without food.\nIf you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture with water. You may save this applesauce mixture for later use in a refrigerator for up to 6 hours.\nStore at room temperature away from moisture and heat.\n','Avoid taking aspirin or other NSAIDs while you are taking Celebrex, unless your doctor tells you to.\nAvoid drinking alcohol. It may increase your risk of stomach bleeding.\nAsk a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to celecoxib (such as aspirin, ibuprofen, ketoprofen, or naproxen).\n'),(135,'celecoxib','Usual Adult Dose for Pain:\nAcute pain: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.\nUsual Adult Dose for Dysmenorrhea:\n400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.\nUsual Adult Dose for Osteoarthritis:\n200 mg orally once daily or 100 mg orally twice daily.\nUsual Adult Dose for Rheumatoid Arthritis:\n100 to 200 mg orally twice daily.\nUsual Adult Dose for Familial Adenomatous Polyposis:\n400 mg orally twice daily with food.\nUsual Adult Dose for Ankylosing Spondylitis:\n200 mg orally once daily or 100 mg orally twice daily. If after 6 weeks of therapy no results are observed, a trial dose of 400 mg orally daily may be worthwhile. If no response is seen after 6 weeks, consideration should be given to alternate treatment options.\nUsual Pediatric Dose for Juvenile Rheumatoid Arthritis:\n2 years or older:\n10 to less than or equal to 25 kg: 50 mg orally twice daily\nGreater than 25 kg: 100 mg orally twice daily\n Detailed Celecoxib dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Ask your doctor before using celecoxib if you take an antidepressant, steroid medicine, or medicine to treat or prevent blood clots. Taking certain medicines with an NSAID may increase your risk of a stomach ulcer or bleeding.\nMany drugs can interact with celecoxib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Celecoxib drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to celecoxib (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nGet emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.\nStop using this medicine and call your doctor at once if you have:\nthe first sign of any skin rash, no matter how mild;\nheart problems - swelling, rapid weight gain, feeling short of breath;\nsigns of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;\nliver problems - nausea, stomach pain (upper right side), itching, tiredness, dark urine, jaundice (yellowing of the skin or eyes);\nkidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or\nlow red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.\nCommon celecoxib side effects may include:\nstomach pain, heartburn, gas, diarrhea, constipation, nausea, vomiting;\nswelling in your hands or feet;\ndizziness; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Celecoxib side effects (more detail)\n','Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.\nCelecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.\nCelecoxib is used to treat juvenile rheumatoid arthritis in children who are at least 2 years old. It is also used in the treatment of hereditary polyps in the colon.\n','Celecoxib can increase your risk of fatal heart attack or stroke, even if you don\'t have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).\nCelecoxib may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults. You should not take this medicine if you already have bleeding in your stomach or intestines.\nBefore taking this medicine\nYou should not use celecoxib if you are allergic to it, or if you have:\nan allergy to sulfa drugs; or\na history of asthma attack or severe allergic reaction after taking aspirin or an NSAID.\nTo make sure celecoxib is safe for you, tell your doctor if you have ever had:\na stomach ulcer, bleeding in your stomach or intestines;\nheart disease, high blood pressure;\nasthma;\nbleeding problems;\nliver or kidney disease; or\nif you smoke or drink alcohol.\nIf you are pregnant, you should not take celecoxib unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.\nThis medicine may affect fertility (ability to have children) in women. Ask your doctor about this risk.\nIt may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.\nHow should I take celecoxib?\nTake celecoxib exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides. Use the lowest dose that is effective in treating your condition.\nYou may take celecoxib with or without food.\nIf you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture with water. You may save this applesauce mixture for later use in a refrigerator for up to 6 hours.\nStore at room temperature away from moisture and heat.\n','Avoid taking aspirin or other NSAIDs while you are taking celecoxib, unless your doctor tells you to.\nAvoid drinking alcohol. It may increase your risk of stomach bleeding.\nAsk a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to celecoxib (such as aspirin, ibuprofen, ketoprofen, or naproxen).\n'),(136,'celexa','Take Celexa exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nMeasure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nIt may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.\nDo not stop using Celexa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.\nStore at room temperature away from moisture and heat.\n Detailed Celexa dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Taking Celexa with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.\nMany drugs can interact with citalopram. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:\ncimetidine;\nlithium;\nSt. John\'s wort;\ntryptophan (sometimes called L-tryptophan);\na blood thinner (warfarin, Coumadin, Jantoven);\nany other antidepressant;\nheart medication;\nmedicine to treat a psychiatric disorder; or\n\"triptan\" migraine headache medicine.\nThis list is not complete and many other drugs can interact with citalopram. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.\n Celexa drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Celexa: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nblurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;\nheadache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;\nsevere nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;\nhigh levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or\nlow levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, feeling unsteady.\nCommon Celexa side effects may include:\nproblems with memory or concentration;\nheadache, drowsiness;\ndry mouth, increased sweating;\nnumbness or tingling;\nincreased appetite, nausea, diarrhea, gas;\nfast heartbeats, feeling shaky;\nsleep problems (insomnia), feeling tired;\ncold symptoms such as stuffy nose, sneezing, sore throat;\nchanges in weight; or\ndifficulty having an orgasm.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Celexa side effects (more detail)\n','Celexa (citalopram) is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).\nCelexa is used to treat depression.\nCelexa may also be used for purposes not listed in this medication guide.\n','You should not use Celexa if you also take pimozide, as the combination can cause problems with your heart rhythm.\nDo not use Celexa if you have used a MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine) or have received a methylene blue injection. A fatal reaction may occur.\nSome young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nDo not give Celexa to anyone younger than 18 years old without the advice of a doctor. Citalopram is not approved for use in children.\nBefore taking this medicine\nYou should not use Celexa if you are allergic to citalopram or escitalopram (Lexapro), or if you also take pimozide.\nDo not use Celexa if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, or methylene blue injection.\nTo make sure Celexa is safe for you, tell your doctor if you have:\na bleeding or blood clotting disorder;\nliver or kidney disease;\nnarrow-angle glaucoma;\nseizures or epilepsy;\nheart disease, heart failure, a heart rhythm disorder, slow heartbeats, or recent history of heart attack;\npersonal or family history of Long QT syndrome;\nan electrolyte imbalance (such as low levels of sodium, potassium or magnesium in your blood);\nbipolar disorder (manic depression); or\na history of drug abuse or suicidal thoughts.\nSome young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nTaking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine during pregnancy without your doctor\'s advice.\nCitalopram can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using Celexa.\nDo not give Celexa to anyone under 18 years old without medical advice. Citalopram is not approved for use in children.\n','Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with Celexa may cause you to bruise or bleed easily.\nDrinking alcohol can increase certain side effects of Celexa.\nCitalopram may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\n'),(137,'cephalexin','Take cephalexin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nDo not use cephalexin to treat any condition that has not been checked by your doctor.\nMeasure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nUse cephalexin for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. This medicine will not treat a viral infection such as the flu or a common cold.\nDo not share cephalexin with another person, even if they have the same symptoms you have.\nThis medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.\nStore the tablets and capsules at room temperature away from moisture, heat, and light.\nStore the liquid medicine in the refrigerator. Throw away any unused liquid after 14 days.\n Detailed Cephalexin dosage information\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, vomiting, stomach pain, diarrhea, and blood in your urine.\n','Tell your doctor about all your other medicines, especially:\nmetformin; or\nprobenecid.\nThis list is not complete. Other drugs may interact with cephalexin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Cephalexin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to cephalexin (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).\nCall your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);\nunusual tiredness, feeling light-headed or short of breath;\neasy bruising, unusual bleeding, purple or red spots under your skin;\na seizure;\npale skin, cold hands and feet;\nyellowed skin, dark colored urine;\nfever, weakness; or\npain in your side or lower back, painful urination.\nCommon cephalexin side effects may include:\ndiarrhea;\nnausea, vomiting;\nindigestion, stomach pain; or\nvaginal itching or discharge.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cephalexin side effects (more detail)\n','Cephalexin is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.\nCephalexin is used to treat infections caused by bacteria, including upper respiratory infections, ear infections, skin infections, urinary tract infections and bone infections.\nCephalexin is used to treat infections in adults and children who are at least 1 year old.\n','You should not use this medicine if you are allergic to cephalexin or to similar antibiotics, such as Ceftin, Cefzil, Omnicef, and others. Tell your doctor if you are allergic to any drugs, especially penicillins or other antibiotics.\nBefore taking this medicine\nDo not use this medicine if you are allergic to cephalexin or to other cephalosporin antibiotics, such as:\ncefaclor (Ceclor, Raniclor);\ncefadroxil (Duricef);\ncefazolin (Ancef, Kefzol);\ncefdinir (Omnicef);\ncefditoren (Spectracef);\ncefpodoxime (Vantin);\ncefprozil (Cefzil);\nceftibuten (Cedax);\ncefuroxime (Ceftin); and others\nTo make sure cephalexin is safe for you, tell your doctor if you have ever had\nan allergy to any drug (especially penicillin);\nliver or kidney disease; or\nintestinal problems, such as colitis.\nCephalexin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant.\nCephalexin can pass into breast milk. Tell your doctor if you are breast-feeding a baby.\n','Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\n'),(138,'cequa','Usual Adult Dose for Keratoconjunctivitis Sicca:\n1 drop 2 times a day in each eye approximately 12 hours apart\nComments:\n-This drug can be used concomitantly with artificial tears, allowing a 15 minute interval between products.\nUse: To increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca\n Detailed Cequa dosage information\nWhat happens if I miss a dose?\nUse the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.\nWhat happens if I overdose?\nAn overdose of Cequa is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.\n','Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.\n','Get emergency medical help if you have signs of an allergic reaction to Cequa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop using Cequa and call your doctor at once if you have:\nsevere eye pain, burning, or stinging after putting in the drops;\nswollen eyelids; or\nsigns of eye infection - swelling, redness, severe discomfort, crusting or drainage.\nCommon Cequa side effects may include:\nmild eye pain, redness, or other irritation;\nwatery eyes;\nblurred vision; or\nfeeling like something is in your eye.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cequa side effects (more detail)\n','Cequa (cyclosporine) is an immunosuppressant. Cequa can increase tear production that has been reduced by inflammation in the eye(s).\nCequa is used to treat chronic dry eye that may be caused by inflammation.\nCequa eye drops are packaged in sterile, preservative-free, single-use vials.\n','Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.\nBefore taking this medicine\nYou should not use Cequa if you are allergic to cyclosporine.\nTell your doctor if you are pregnant or breastfeeding.\nCequa is not approved for use by anyone younger than 16 years old.\nHow should I use Cequa?\nUse Cequa eye drops exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nUse the medicine about every 12 hours. Remove contact lenses first.\nWash your hands before using eye medication.\nTo apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye and squeeze a drop into this pocket. Close your eyes for 1 or 2 minutes.\nUse only the number of drops your doctor has prescribed.\nWait at least 15 minutes before inserting contact lenses or using artificial tears.\nDo not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.\nCequa eye drops should be clear and colorless.\nEach single-use bottle is for one use only (in both eyes). Throw the bottle away after one use, even if there is still medicine left inside.\nStore at room temperature. Store Cequa single-use vials in their original foil pouch.\n','It may be best not to wear contact lenses if you have dry eyes. Talk with your doctor.\n'),(139,'cetirizine-hcl','Take cetirizine exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.\nYou may take cetirizine with or without food.\nThe chewable tablet must be chewed before you swallow it.\nMeasure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.\n Detailed Cetirizine dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nOverdose symptoms may include feeling restless or nervous, and then feeling drowsy.\n','There may be other drugs that can interact with cetirizine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.\n Cetirizine drug interactions (more detail)\n','\nfast, pounding, or uneven heartbeat;\nweakness, tremors (uncontrolled shaking), or sleep problems (insomnia);\nsevere restless feeling, hyperactivity;\nconfusion;\nproblems with vision; or\nurinating less than usual or not at all.\nLess serious side effects may include:\ndizziness, drowsiness;\ntired feeling;\ndry mouth;\nsore throat, cough;\nnausea, constipation; or\nheadache.\nThis is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.\n Cetirizine side effects (more detail)\n','Cetirizine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. It is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.\nCetirizine is also used to treat itching and swelling caused by hives.\nCetirizine may also be used for other purposes not listed in this medication guide.\n','Before taking this medicine\nBefore taking cetirizine, tell your doctor about all of your medical conditions.\nOlder adults may need to take a lower than normal dose. Follow your doctor\'s instructions.\n',NULL),(140,'chlorthalidone','Usual Adult Dose for Hypertension:\n-Initial dose: 25 mg orally once a day-Titration: Increase to 50 mg orally once a day if response is inadequate; if response is still inadequate, increase to 100 mg orally once a day, or a second antihypertensive drug (step 2 therapy) may be added-Maintenance dose: 25 to 100 mg orally once a day-Maximum dose: 100 mg orally once a dayComments:-Doses should be taken in the morning with food.-Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response.  -Effectiveness is well sustained during continued use.Use: Hypertension (alone or with another antihypertensive drug)\nUsual Adult Dose for Edema:\n-Initial dose: 50 to 100 mg orally once a day, or 100 mg orally every other day; some patients may require 150 to 200 mg orally at these intervals-Maximum dose: 200 mg orally once a dayComments:-Doses should be taken in the morning with food.-Maintenance doses may be lower than initial doses and should be adjusted according to individual patient response.  -Effectiveness is well sustained during continued use.Use: For edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure\n Detailed Chlorthalidone dosage information\n','Using chlorthalidone with other drugs that make you light-headed can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.\nTell your doctor about all your other medicines, especially:\nother blood pressure medications;\nlithium;\ndigoxin, digitalis;\ninsulin or oral diabetes medicine; or\nsteroid medicine.\nThis list is not complete. Other drugs may affect chlorthalidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Chlorthalidone drug interactions (more detail)\nDoes Chlorthalidone interact with my other drugs?\nEnter other medications to view a detailed report.\nDrug name\nAdd a drug to check interactions\nAdd\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nlow sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;\nlow potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;\nlow magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or\nkidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath.\nCommon side effects may include:\nlow blood pressure (feeling light-headed);\nkidney problems;\ndizziness; or\nan electrolyte imbalance (such as low levels of potassium, sodium, or magnesium in your blood).\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Chlorthalidone side effects (more detail)\n','Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.\nChlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen.\nChlorthalidone is also used to treat high blood pressure (hypertension).\nChlorthalidone may also be used for purposes not listed in this medication guide.\n','You should not use chlorthalidone if you are unable to urinate, or if you are allergic to sulfa drugs.\nBefore taking this medicine\nYou should not use chlorthalidone if you are allergic to it, or if:\nyou are unable to urinate; or\nyou are allergic to sulfa drugs.\nTell your doctor if you have ever had:\nkidney disease;\nheart failure;\ngout;\nhigh cholesterol or triglycerides;\ndiabetes; or\nif you are on a low-salt diet.\nTell your doctor if you are pregnant or plan to become pregnant. Taking chlorthalidone during pregnancy may cause side effects in the newborn baby, such as jaundice (yellowing of the skin or eyes), bruising or bleeding, low blood sugar, or an electrolyte imbalance.\nDo not start or stop taking chlorthalidone during pregnancy without your doctor\'s advice. Although chlorthalidone may cause side effects in a newborn, having high blood pressure during pregnancy can cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.\nYou should not breastfeed while using chlorthalidone.\nHow should I take chlorthalidone?\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.\nCall your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking chlorthalidone. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.\nYour blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated.\n chlorthalidone can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorthalidone.\nIf you need surgery, tell your surgeon you currently use this medicine.\nIf you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.\nStore this medicine at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\nOverdose symptoms may include nausea, weakness, dizziness, drowsiness, extreme thirst, muscle pain, or rapid heartbeats.\n','Drinking alcohol with  chlorthalidone can cause side effects.\nAvoid getting up too fast from a sitting or lying position, or you may feel dizzy.\nAvoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor\'s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.\n'),(141,'cholecalciferol','Usual Adult Dose for Vitamin/Mineral Supplementation:\nUS Recommended Dietary Allowance (RDA) for vitamin D:18 to 70 years: 15 mcg (600 international units) dailyTolerable Upper Intake Level: 100 mcg (4000 international units)\nUsual Geriatric Dose for Vitamin/Mineral Supplementation:\nUS Recommended Dietary Allowance (RDA) for vitamin D:70 years and older: 20 mcg (800 international units) dailyTolerable Upper Intake Level: 100 mcg (4000 international units)\nUsual Pediatric Dose for Vitamin/Mineral Supplementation:\nUS Recommended Dietary Allowance (RDA) for vitamin D:0 to 6 months: 10 mcg (400 international units) dailyTolerable Upper Intake Level (UL): 25 mcg (1000 international units)7 to 12 months: 10 mcg (400 international units) dailyUL: 38 mcg (1500 international units)1 to 3 years: 15 mcg (600 international units) dailyUL: 63 mcg (2500 international units)4 to 8 years: 15 mcg (600 international units) dailyUL: 75 mcg (3000 international units)9 to 18 years: 15 mcg (600 international units) dailyUL: 100 mcg (4000 international units)\n Detailed Cholecalciferol dosage information\nFree Drugs.com Discount Card\nSave up to 80% on your prescriptions.\nAccepted at over 65,000 pharmacies.\nGet Discount Card\n','Certain medications can make it harder for your body to absorb vitamin D. If you take other medications, take them at least 2 hours before or 2 hours after you take cholecalciferol.\nOther drugs may affect cholecalciferol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.\n Cholecalciferol drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.\nStop taking this medicine and call your doctor at once if you have:\nchest pain, feeling short of breath;\ngrowth problems (in a child taking cholecalciferol); or\nearly signs of vitamin D overdose--weakness, metallic taste in your mouth, weight loss, muscle or bone pain, constipation, nausea, and vomiting.\nLess serious side effects may be more likely, and you may have none at all.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cholecalciferol side effects (more detail)\n','Cholecalciferol is vitamin D3. Vitamin D helps your body absorb calcium.\nCholecalciferol is used as a dietary supplement in people who do not get enough vitamin D in their diets to maintain adequate health.\nCholecalciferol may also be used for purposes not listed in this medication guide.\n','You should not take cholecalciferol if you have had an allergic reaction to vitamin D, or if you have high levels of calcium or vitamin D in your body, or any condition that makes it hard for your body to absorb nutrients from food (malabsorption).\nBefore taking this medicine\nYou should not use cholecalciferol if you have had an allergic reaction to vitamin D, or if you have:\nhigh levels of vitamin D in your body (hypervitaminosis D);\nhigh levels of calcium in your blood (hypercalcemia); or\nany condition that makes it hard for your body to absorb nutrients from food (malabsorption).\nTell your doctor if you have ever had:\nheart disease;\nkidney disease; or\nan electrolyte imbalance.\nCertain forms of cholecalciferol may contain ingredients you should know about, such as peanut or soybean oil, sugar, aspartame (phenylalanine), or certain food dyes. Ask a doctor before using cholecalciferol if you have allergies, diabetes, or phenylketonuria (PKU).\nToo much vitamin D could harm an unborn baby or a nursing baby. Ask a doctor before using this medicine if you are pregnant or breast-feeding. Your dose needs may be different during pregnancy or while you are nursing.\nDo not give cholecalciferol to a child without medical advice. Your child\'s dose will depend on age, weight, diet, and other factors.\nHow should I take cholecalciferol?\nFollow all directions on your prescription label and read all medication guides or instruction sheets. Use only the recommended dose of cholecalciferol.\nIt may be best to take cholecalciferol after a meal, but you may take this medicine with or without food.\nMeasure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).\nThe chewable tablet must be chewed before you swallow it.\nTo take a disintegrating (Quick-Melt) tablet, place it on your tongue and do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.\nThe cholecalciferol wafer is usually taken only once per week or once per month. Follow your doctor\'s dosing instructions very carefully. The wafer must be chewed before you swallow it.\nWhile using cholecalciferol, you will need frequent blood tests. You may also need x-rays.\nYour doctor will determine how long to treat you with this medicine.\nCholecalciferol may be only part of a complete program of treatment that also includes dietary changes and taking calcium and vitamin supplements. Follow your doctor\'s instructions very closely.\nLearn about the foods you should eat to make sure you get enough calcium and vitamin D in your diet. Your cholecalciferol dose may need to be adjusted as you make changes to your diet.\nStore at room temperature away from moisture, light, and heat.\nWhat happens if I miss a dose?\nTake the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of vitamin D can cause serious or life-threatening side effects.\nOverdose symptoms may include nausea, loss of appetite, thirst, urinating more or less than usual, body aches, stiffness, confusion, or irregular heartbeats.\n','Ask a doctor or pharmacist before taking any multivitamins, mineral supplements, or antacids while you are taking cholecalciferol.\n'),(142,'cialis','Cialis is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.\nCialis can be taken with or without food.\nDo not break or split a tablet. Swallow it whole.\nFor erectile dysfunction, take Cialis just before sexual activity but not more than once per day.\nCialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor\'s instructions.\nDo not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.\nStore at room temperature away from moisture and heat.\n Detailed Cialis dosage information\nWhat happens if I miss a dose?\nAs Cialis is used as needed, you are not likely to be on a dosing schedule.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your current medicines and any you start or stop using, especially:\nmedicines to treat erectile dysfunction or pulmonary arterial hypertension;\nan antibiotic or antifungal medicine;\nantiviral medicine to treat hepatitis C or HIV/AIDS;\ndrugs to treat high blood pressure or a prostate disorder; or\nseizure medicine.\nThis list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.\n Cialis drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Cialis: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nStop and get medical help at once if you have nausea, chest pain, or dizziness during sex. You could be having a life-threatening side effect.\nStop using this medicine and call your doctor at once if you have:\na light-headed feeling, like you might pass out;\nan erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis);\nvision changes or sudden vision loss;\nringing in your ears or sudden hearing loss; or\nheart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.\nCommon Cialis side effects may include:\nheadache;\nflushing (warmth, redness, or tingly feeling);\nnausea, upset stomach;\nstuffy nose; or\nmuscle pain, back pain, pain in your arms, legs, or back.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cialis side effects (more detail)\n','Cialis (tadalafil) relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.\nCialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).\nAnother brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Cialis while also taking Adcirca, unless your doctor tells you to.\n','Do not take Cialis if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as \"poppers\". Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.\nSome medicines can cause unwanted or dangerous effects when used with Cialis. Tell your doctor about all your current medicines, especially riociguat (Adempas).\nContact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.\nGet medical help at once if you have nausea, chest pain, or dizziness during sex.\nStop using Cialis and get emergency medical help if you have sudden vision loss.\nBefore taking this medicine\nYou should not take Cialis if you are allergic to tadalafil.\nTaking Cialis with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take this medicine if you also use:\nriociguat (to treat pulmonary arterial hypertension); or\na nitrate drug (for chest pain or heart problems) such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as amyl nitrate or nitrite \"poppers\".\nSome tadalafil can remain in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). Avoid nitrate use during this time.\nTo make sure this Cialis is safe for you, tell your doctor if you have ever had:\nheart disease or heart rhythm problems;\na heart attack or stroke;\nangina (chest pain), high or low blood pressure;\npulmonary hypertension (unless you are taking tadalafil for this);\na condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart);\nliver or kidney disease (or if you are on dialysis);\nvision loss, or retinitis pigmentosa (an inherited condition of the eye);\na bleeding disorder;\na blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;\na physical deformity of the penis (such as Peyronie\'s disease), or an erection lasting longer than 4 hours;\na stomach ulcer; or\nhealth problems that make sexual activity unsafe.\nSudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others). Most of these people already had certain eye problems or had high cholesterol, diabetes, coronary artery disease, a history of smoking, or were over 50 years old). It is not clear whether the medicine was the actual cause of vision loss.\nCialis is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.\nIt is not known whether tadalafil passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.\nCialis is not approved for use by anyone younger than 18 years old.\n','Drinking alcohol with this medicine can cause side effects.\nGrapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.\n'),(143,'cimzia','Usual Adult Dose for Rheumatoid Arthritis:\nInitial dose: 400 mg subcutaneously (given as two subcutaneous injections of 200 mg) at weeks 0, 2, and 4, followed by 200 mg subcutaneously every other week\nMaintenance dose: 400 mg subcutaneously every 4 weeks in patients who obtain a clinical response\nComments:\n-Injection sites should be rotated and injections should not be given in areas where the skin is tender, bruised, red, or hard. When a 400 mg dose is needed (given as 2 subcutaneous injections of 200 mg), injections should occur at separate sites in the thigh or abdomen.\nUse: For treatment of adults with moderately to severely active rheumatoid arthritis (RA)\nUsual Adult Dose for Psoriatic Arthritis:\nInitial dose: 400 mg subcutaneously (given as two subcutaneous injections of 200 mg) at weeks 0, 2, and 4, followed by 200 mg subcutaneously every other week\nMaintenance dose: 400 mg subcutaneously every 4 weeks in patients who obtain a clinical response\nComments:\n-Injection sites should be rotated and injections should not be given in areas where the skin is tender, bruised, red, or hard. When a 400 mg dose is needed (given as 2 subcutaneous injections of 200 mg), injections should occur at separate sites in the thigh or abdomen.\n-This drug can be given as monotherapy in case of intolerance to methotrexate (MTX) or when continued treatment with methotrexate is inappropriate.\n-MTX should be continued during treatment with this drug where appropriate.\n-Injection sites should be rotated and injections should not be given in areas where the skin is tender, bruised, red, or hard. When a 400 mg dose is needed (given as 2 subcutaneous injections of 200 mg), injections should occur at separate sites in the thigh or abdomen.\nUse: For the treatment of adult patients with active psoriatic arthritis (PsA)\nUsual Adult Dose for Ankylosing Spondylitis:\nInitial dose: 400 mg subcutaneously (given as two subcutaneous injections of 200 mg) at weeks 0, 2, and 4, followed by 200 mg subcutaneously every 2 weeks or 400 mg subcutaneously every 4 weeks\nComments:\n-Injection sites should be rotated and injections should not be given in areas where the skin is tender, bruised, red, or hard. When a 400 mg dose is needed (given as 2 subcutaneous injections of 200 mg), injections should occur at separate sites in the thigh or abdomen.\nUse: For the treatment of adults with active ankylosing spondylitis\nUsual Adult Dose for Crohn\'s Disease -- Maintenance:\nInitial dose: 400 mg subcutaneously (given as two subcutaneous injections of 200 mg) at weeks 0, 2, and 4\nMaintenance dose: 400 mg subcutaneously every 4 weeks in patients who obtain a clinical response\nComments:\n-Injection sites should be rotated and injections should not be given in areas where the skin is tender, bruised, red, or hard. When a 400 mg dose is needed (given as 2 subcutaneous injections of 200 mg), injections should occur at separate sites in the thigh or abdomen.\nUse: For reducing signs of Crohn\'s disease and maintaining clinical response in adult patients with moderately to severely active disease who have had an inadequate response to conventional therapy\n Detailed Cimzia dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss a dose of Cimzia.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your other medicines, especially:\nabatacept;\nadalimumab;\nanakinra;\netanercept;\ngolimumab;\ninfliximab;\nnatalizumab; or\nrituximab.\nThis list is not complete. Other drugs may interact with certolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Cimzia drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction ti Cimzia: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nSerious and sometimes fatal infections may occur during treatment with Cimzia. Tell your doctor if you have signs of infection, such as: fever, chills, cough, sweating, muscle pain, open sores or skin wounds, unusual tiredness, feeling short of breath, painful urination, diarrhea, or weight loss.\nCall your doctor right away if you have any of these symptoms of lymphoma:\nchest pain, cough, feeling short of breath;\nswelling in your neck, underarm, or groin (this swelling may come and go);\nfever, night sweats, itching, weight loss, feeling tired;\nfeeling full after eating only a small amount; or\npain in your upper stomach that may spread to your back or shoulder.\nStop using Cimzia and call your doctor at once if you have:\nshortness of breath (even with mild exertion), swelling, rapid weight gain;\npale skin, easy bruising or bleeding;\na new growth on your skin (may be red or purple), or any change in the size or color of a mole, freckle, or bump on your skin;\nnerve problems - vision problems, dizziness, numbness or tingly feeling, muscle weakness in your arms or legs;\nliver problems - loss of appetite, right-sided stomach pain, tiredness, jaundice (yellowing of the skin or eyes); or\nnew or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.\nCommon Cimzia side effects may include:\npain or burning when you urinate;\nrash; or\ncold symptoms such as stuffy nose, sneezing, sore throat.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cimzia side effects (more detail)\n','Cimzia (certolizumab)reduces the effects of a substance in the body that can cause inflammation.\nCimzia is used to treat the symptoms of Crohn\'s disease after other treatments have failed.\nCimzia is also used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and non-radiographic axial spondyloarthritis.\n','Cimzia affects your immune system. Serious and sometimes fatal infections may occur.\nYour risk of infection may be higher if you have diabetes, HIV, a weak immune system, hepatitis B, chronic infections, if you use certain medications, or if you live in or travel to certain areas.\nCall your doctor at once if you have symptoms such as fever, chills, cough, diarrhea, night sweats, flu symptoms, or skin sores.\nUsing Cimzia may also increase your risk of developing certain types of cancer, including a rare fast-growing type of lymphoma that can be fatal.\nDo not receive a \"live\" vaccine while you are being treated with Cimzia.\nBefore taking this medicine\nYou should not use Cimzia if you are allergic to certolizumab. You may not be able to use Cimzia if you have symptoms of an infection such as fever, chills, cough, skin sores, shortness of breath, weight loss, diarrhea, or painful urination.\nTell your doctor if you have ever had tuberculosis, or anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.\nCimzia may cause a rare type of lymphoma (cancer) of the liver, spleen, and bone marrow that can be fatal. This has occurred mainly in teenagers and young men with Crohn\'s disease or ulcerative colitis. However, anyone with an inflammatory autoimmune disorder may have a higher risk of lymphoma. Talk with your doctor about your own risk.\nTell your doctor if you have ever had:\na chronic infection;\nhepatitis B (or if you are a carrier of the virus);\nlymphoma or other types of cancer;\na blood cell disorder;\ncongestive heart failure;\na seizure;\nan allergy to latex;\nnumbness or tingling, or a nervous system disorder such as multiple sclerosis; or\nif you are scheduled to receive any vaccines, or have recently been vaccinated with BCG (Bacille Calmette-Guerin).\nIt is not known whether Cimzia will harm an unborn baby. Tell your doctor if you are pregnant. Your name may be listed on a pregnancy registry to track the effects of Cimzia on the baby.\nIt may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.\nCimzia is not approved for use by anyone younger than 18 years old.\nHow is Cimzia given?\nBefore you start treatment with Cimzia, your doctor may perform tests to make sure you do not have tuberculosis or other infections.\nCimzia is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.\nCimzia is usually given every 2 to 4 weeks. You may need to use more than 1 injection to get a full dose. Follow your doctor\'s dosing instructions very carefully.\nRead and carefully follow any Instructions for Use provided with your medicine. Do not use Cimzia if you don\'t understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.\nPrepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.\nCimzia can increase your risk of bleeding or infection by changing the way your immune system works. You will need frequent medical tests.\nStore Cimzia in its original carton in the refrigerator. Protect from light and do not freeze.\nTake the syringe out of the refrigerator and let it reach room temperature before injecting your dose.\nUnopened prefilled syringes may also be stored at room temperature for up to 7 days, away from heat and light. Throw away any prefilled syringe not used within 7 days. Do not put it back in the refrigerator.\nEach prefilled syringe is for one use only. Throw away after one use, even if there is still medicine left inside.\nUse a needle and syringe only once and then place them in a puncture-proof \"sharps\" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.\nIf you\'ve ever had hepatitis B, using Cimzia can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.\n','Avoid injecting Cimzia into scars or stretch marks, or into skin that is red, bruised, swollen, hard, or tender.\nAsk your doctor before receiving any vaccine while you are being treated with Cimzia.\nAvoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.\n'),(144,'cinryze','Usual Adult Dose for Hereditary Angioedema:\nFor routine prophylaxis against angioedema attacks in HAE patients.\n1,000 Units by intravenous infusion at a rate of 1 mL per minute (1,000 units/ 10 mL) every 3 or 4 days.\n Detailed Cinryze dosage information\nWhat happens if I miss a dose?\nCall your doctor for instructions if you miss a dose.\nKeep this medicine on hand at all times to prevent angioedema, especially while traveling.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Tell your doctor about all your other medicines, especially:\ntestosterone; or\nbirth control pills.\nThis list is not complete. Other drugs may interact with complement C1 esterase inhibitor, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Cinryze drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Cinryze: hives; chest tightness, fast heartbeats, feeling light-headed; wheezing or difficult breathing, blue lips or gums; or swelling of your face, lips, tongue, or throat.\nCall your doctor at once if you have:\nsudden numbness or weakness on one side of the body;\npain, swelling, warmth, or redness in an arm or leg;\nsudden severe headache, confusion, problems with vision, speech, or balance;\nchest pain while taking deep breaths; or\nfast heart rate.\nCommon Cinryze side effects may include:\nunusual or unpleasant taste in your mouth;\nheadache, dizziness;\nnausea, vomiting;\npain, bruising, itching, swelling, bleeding, warmth, or a hard lump where the medicine was injected;\nstuffy nose, sore throat;\nrash; or\nfever.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cinryze side effects (more detail)\n','Cinryze (complement C1 esterase inhibitor) is a man-made form of a protein that occurs naturally in the blood stream and helps control swelling in the body. People with a condition called hereditary angioedema do not have enough of this protein. Hereditary angioedema can cause attacks of swelling and symptoms such as stomach problems or trouble breathing.\nCinryze is used to prevent attacks of angioedema.\nThe Berinert brand of complement C1 esterase inhibitor is used to treat attacks of angioedema.\n','You should not use Cinryze if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.\nBefore you receive Cinryze, tell your doctor if you have a history of stroke or blood clot.\nDo not give this medication to a child without medical advice.\nYou may be shown how to use Cinryze in an IV at home. Cinryze comes with patient instructions for safe and effective use. Follow all directions carefully. Ask your doctor or pharmacist if you have any questions.\nDo not self-inject Cinryze if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Be sure you understand how to properly mix and store the medication. Stop your IV infusion and get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your face, lips, tongue, or throat.\nCinryze is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.\nBefore taking this medicine\nYou should not use Cinryze if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.\nTell your doctor if you have ever had:\na stroke or blood clot;\nheart problems; or\nan \"in-dwelling\" catheter.\nTell your doctor if you are pregnant or breast-feeding.\nCinryze is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.\nHow should I use Cinryze?\nUse Cinryze exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nCinryze is injected into a vein through an IV.\nYou may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.\nCinryze is usually given every 3 or 4 days to prevent angioedema attacks.\nRead all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.\nCinryze is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using this medicine at home, you will need to use two vials to make up a single dose. Follow all directions carefully. Be sure you understand how to properly mix and store the medicine.\nGently swirl but do not shake the mixed medicine or you may ruin it. Prepare your dose only when you are ready to give yourself an injection.\nThe powder and diluent mixture should be clear and colorless. Mixed Cinryze should be clear or slightly blue in color. Do not use the mixed medicine if it has changed colors or has particles in it. Call your pharmacist for new medicine.\nEach single-use vial (bottle) of Cinryze is for one use only. Throw it away after one use, even if there is still medicine left inside.\nCinryze contains no preservative. Once you have pierced the rubber top of a vial with a needle, you must use that vial right away or throw it away.\nStore the unmixed dry powder in a refrigerator or at cool room temperature. Protect from light and do not freeze. Throw away any unused vial after the expiration date on the label has passed.\nAfter mixing Cinryze with the diluent, use the injection right away or store the mixture at room temperature and use it within 3 hours.\nUse a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof \"sharps\" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.\n','Follow your doctor\'s instructions about any restrictions on food, beverages, or activity.\n'),(145,'cipro','Take Cipro exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nTake Cipro at the same time each day, with or without food.\nShake the Cipro oral suspension (liquid) for 15 seconds before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Do not give Cipro oral suspension through a feeding tube.\nDrink plenty of liquids while you are taking this medicine .\nUse this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ciprofloxacin will not treat a viral infection such as the flu or a common cold.\nDo not share Cipro with another person.\nStore at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze. Throw away any unused liquid after 14 days.\n Detailed Cipro dosage information\nWhat happens if I miss a dose?\nIf you take regular tablets or oral suspension: Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 6 hours.\nDo not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Some medicines can make Cipro much less effective when taken at the same time. If you take any of the following medicines, take your dose 2 hours before or 6 hours after you take the other medicine.\nthe ulcer medicine sucralfate, or antacids that contain calcium, magnesium, or aluminum (such as Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Tums, and others);\ndidanosine (Videx) powder or chewable tablets;\nvitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.\nTell your doctor about all your other medicines, especially:\nclozapine, cyclosporine, methotrexate, phenytoin, probenecid, ropinirole, sildenafil, or theophylline;\na blood thinner (warfarin, Coumadin, Jantoven);\nheart medication or a diuretic or \"water pill\";\noral diabetes medicine;\nproducts that contain caffeine;\nmedicine to treat depression or mental illness;\nsteroid medicine (such as prednisone); o\nNSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;\nThis list is not complete. Other drugs may interact with ciprofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Cipro drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to Cipro (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).\nCiprofloxacin can cause serious side effects, including tendon problems, damage to your nerves (which may be permanent), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).\nStop taking this medicine and call your doctor at once if you have:\nlow blood sugar - headache, hunger, irritability, dizziness, nausea, fast heart rate, or feeling shaky;\nnerve damage symptoms - numbness, tingling, burning pain in your hands, arms, legs, or feet:\nserious mood or behavior changes - nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or\nsigns of tendon rupture - sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).\nIn rare cases, ciprofloxacin may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.\nAlso, stop using Cipro and call your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\nfast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);\nany skin rash, no matter how mild;\nmuscle weakness, breathing problems;\nlittle or no urination;\njaundice (yellowing of the skin or eyes); or\nincreased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.\nCommon Cipro side effects may include:\nnausea, vomiting, diarrhea, stomach pain;\nheadache; or\nabnormal liver function tests.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Cipro side effects (more detail)\n','Cipro (ciprofloxacin) is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body.\nCipro is used to treat different types of bacterial infections. Cipro is also used to treat people who have been exposed to anthrax or certain types of plague.\nFluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible.\nCipro should be used only for infections that cannot be treated with a safer antibiotic.\n','Cipro can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar.\nStop using this medicine and call your doctor at once if you have: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.\nIn rare cases, ciprofloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.\nYou may not be able to use Cipro if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis.\nBefore taking this medicine\nYou should not use Cipro if you are allergic to ciprofloxacin, or if:\nyou also take tizanidine; or\nyou are allergic to other fluoroquinolones (levofloxacin, moxifloxacin, norfloxacin, ofloxacin).\nCiprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles\' tendon of the heel. This can happen during treatment or several months after you stop taking Cipro. Tendon problems may be more likely in children and older adults, or people who use steroid medicine or have had an organ transplant.\nTo make sure Cipro is safe for you, tell your doctor if you have ever had:\narthritis or problems with your tendons, bones or joints (especially in children);\ndiabetes, low blood sugar;\nnerve problems;\nan aneurysm or blood circulation problems;\nheart problems, or a heart attack;\nmuscle weakness, myasthenia gravis;\nliver or kidney disease;\na seizure, head injury, or brain tumor;\ntrouble swallowing pills;\nlong QT syndrome (in you or a family member); or\nlow levels of potassium in your blood (hypokalemia).\nDo not give Cipro to a child without medical advice.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.\nYou should not breastfeed while taking ciprofloxacin and for 2 days after your last dose. Ask your doctor about breastfeeding if you take ciprofloxacin for anthrax exposure.\n','Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products with your meals, but do not use them alone when taking Cipro.\nAntibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\nCiprofloxacin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.\nAvoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.\n'),(146,'ciprofloxacin','Take ciprofloxacin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.\nTake ciprofloxacin at the same time each day, with or without food.\nShake the oral suspension (liquid) for 15 seconds before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Do not give ciprofloxacin oral suspension through a feeding tube.\nSwallow the extended-release tablet whole and do not crush, chew, or break it.\nDrink plenty of liquids while you are taking this medicine.\nUse ciprofloxacin for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ciprofloxacin will not treat a viral infection such as the flu or a common cold.\nDo not share this medicine with another person.\nStore at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze. Throw away any unused liquid after 14 days.\n Detailed Ciprofloxacin dosage information\nWhat happens if I miss a dose?\nIf you take regular tablets or oral suspension: Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 6 hours.\nIf you take extended-release tablets: Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 8 hours.\nDo not take two doses at one time.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Some medicines can make ciprofloxacin much less effective when taken at the same time. If you take any of the following medicines, take your ciprofloxacin dose 2 hours before or 6 hours after you take the other medicine.\nthe ulcer medicine sucralfate, or antacids that contain calcium, magnesium, or aluminum (such as Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Tums, and others);\ndidanosine (Videx) powder or chewable tablets;\nvitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.\nTell your doctor about all your other medicines, especially:\nclozapine, cyclosporine, methotrexate, phenytoin, probenecid, ropinirole, sildenafil, or theophylline;\na blood thinner (warfarin, Coumadin, Jantoven);\nheart medication or a diuretic or \"water pill\";\noral diabetes medicine;\nproducts that contain caffeine;\nmedicine to treat depression or mental illness;\nsteroid medicine (such as prednisone); o\nNSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;\nThis list is not complete. Other drugs may interact with ciprofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.\n Ciprofloxacin drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to ciprofloxacin (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).\nCiprofloxacin can cause serious side effects, including tendon problems, damage to your nerves (which may be permanent), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).\nStop taking this medicine and call your doctor at once if you have:\nlow blood sugar - headache, hunger, irritability, dizziness, nausea, fast heart rate, or feeling shaky;\nnerve damage symptoms - numbness, tingling, burning pain in your hands, arms, legs, or feet:\nserious mood or behavior changes - nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or\nsigns of tendon rupture - sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).\nIn rare cases, ciprofloxacin may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.\nAlso, stop using this medicine and call your doctor at once if you have:\nsevere stomach pain, diarrhea that is watery or bloody;\nfast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);\nany skin rash, no matter how mild;\nmuscle weakness, breathing problems;\nlittle or no urination;\njaundice (yellowing of the skin or eyes); or\nincreased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.\nCommon ciprofloxacin side effects may include:\nnausea, vomiting, diarrhea, stomach pain;\nheadache; or\nabnormal liver function tests.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Ciprofloxacin side effects (more detail)\n','Ciprofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic, it is used to treat different types of bacterial infections. It is also used to treat people who have been exposed to anthrax or certain types of plague. Ciprofloxacin extended-release is only approved for use in adults.\nFluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible.\nCiprofloxacin should be used only for infections that cannot be treated with a safer antibiotic.\n','Ciprofloxacin can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar.\nStop using ciprofloxacin and call your doctor at once if you have: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.\nIn rare cases, ciprofloxacin may cause damage to your aorta, which could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.\nYou may not be able to use this medicine if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis.\nBefore taking this medicine\nYou should not use ciprofloxacin if you are allergic to it, or if:\nyou also take tizanidine; or\nyou are allergic to other fluoroquinolones (levofloxacin, moxifloxacin, norfloxacin, ofloxacin).\nCiprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles\' tendon of the heel. This can happen during treatment or several months after you stop taking ciprofloxacin. Tendon problems may be more likely in children and older adults, or people who use steroid medicine or have had an organ transplant.\nTo make sure ciprofloxacin is safe for you, tell your doctor if you have ever had:\narthritis or problems with your tendons, bones or joints (especially in children);\ndiabetes, low blood sugar;\nnerve problems;\nan aneurysm or blood circulation problems;\nheart problems, or a heart attack;\nmuscle weakness, myasthenia gravis;\nliver or kidney disease;\na seizure, head injury, or brain tumor;\ntrouble swallowing pills;\nlong QT syndrome (in you or a family member); or\nlow levels of potassium in your blood (hypokalemia).\nDo not give this medicine to a child without medical advice.\nIt is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.\nYou should not breastfeed while taking ciprofloxacin and for 2 days after your last dose. Ask your doctor about breastfeeding if you take this medicine for anthrax exposure.\n','Do not take ciprofloxacin with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products with your meals, but do not use them alone when taking this medicine.\nAntibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.\nCiprofloxacin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.\nAvoid driving or hazardous activity until you know how ciprofloxacin will affect you. Your reactions could be impaired.\n'),(147,'citalopram','Take citalopram exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.\nMeasure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.\nIt may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.\nDo not stop using citalopram suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.\nStore at room temperature away from moisture and heat.\n Detailed Citalopram dosage information\nWhat happens if I miss a dose?\nTake the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.\nWhat happens if I overdose?\nSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.\n','Taking citalopram with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.\nMany drugs can interact with citalopram. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:\ncimetidine;\nlithium;\nSt. John\'s wort;\ntryptophan (sometimes called L-tryptophan);\na blood thinner (warfarin, Coumadin, Jantoven);\nany other antidepressant;\nheart medication;\nmedicine to treat a psychiatric disorder; or\n\"triptan\" migraine headache medicine.\nThis list is not complete and many other drugs can interact with citalopram. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.\n Citalopram drug interactions (more detail)\n','Get emergency medical help if you have signs of an allergic reaction to citalopram: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nCall your doctor at once if you have:\na light-headed feeling, like you might pass out;\nblurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;\nheadache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;\nsevere nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;\nhigh levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or\nlow levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, feeling unsteady.\nCommon citalopram side effects may include:\nproblems with memory or concentration;\nheadache, drowsiness;\ndry mouth, increased sweating;\nnumbness or tingling;\nincreased appetite, nausea, diarrhea, gas;\nfast heartbeats, feeling shaky;\nsleep problems (insomnia), feeling tired;\ncold symptoms such as stuffy nose, sneezing, sore throat;\nchanges in weight; or\ndifficulty having an orgasm.\nThis is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.\n Citalopram side effects (more detail)\n','Citalopram is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs).\nCitalopram is used to treat depression.\nCitalopram may also be used for purposes not listed in this medication guide.\n','You should not use citalopram if you also take pimozide, or if you are being treated with methylene blue injection.\nDo not use citalopram if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.\nSome young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.\nReport any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.\nDo not give citalopram to anyone younger than 18 years old without the advice of a doctor. This medicine is not approved for use in children.\nBefore taking this medicine\nYou should not use this medicine if you are allergic to citalopram or escitalopram (Lexapro), or if you also take pimozide.\nDo not use citalopram if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.\nTo make sure citalopram is safe for you, tell your doctor if you have:\na bleeding or blood clotting disorder;\nliver or kidney disease;\nnarrow-angle glaucoma;\nseizures or epilepsy;\nheart disease, heart failure, a heart rhythm disorder, slow heartbeats, or recent history of heart attack;\npersonal or family history of Long QT syndrome;\nan electrolyte imbalance (such as low levels of potassium or magnesium in your blood);\nbipolar disorder (manic depression); or\na history of drug abuse or suicidal thoughts.\nSome young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.\nTaking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine during pregnancy without your doctor\'s advice.\nCitalopram can pass into breast milk and may harm a nursing baby. You should discuss the risks and benefits of using citalopram if you are breast-feeding.\nDo not give this medicine to anyone under 18 years old without medical advice. Citalopram is not approved for use in children.\n','Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with citalopram may cause you to bruise or bleed easily.\nDrinking alcohol can increase certain side effects of citalopram.\nCitalopram may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.\n');
