Zeposia can cause serious side effects, including:
See Important information
liver problems. Zeposia may cause liver problems. Your healthcare provider will do blood tests to check your liver before you start treatment. Call your healthcare provider right away if have any of the following symptoms:
unexplained nausea
vomiting
stomach area (abdominal) pain
tiredness
loss of appetite
yellowing of the whites of your eyes or skin
dark colored urine
increased blood pressure. Your healthcare provider should check your blood pressure during treatment. A sudden, severe increase in blood pressure (hypertensive crisis) can happen when you eat certain foods that contain high levels of tyramine. See How should I take Zeposia? section for more information.
breathing problems. Some people who take Zeposia have shortness of breath. Call your healthcare provider right away if you have new or worsening breathing problems.
a problem with your vision called macular edema. Your risk for macular edema is higher if you have diabetes or have had an inflammation of your eye called uveitis. Your healthcare provider should test your vision before you start treatment if you are at higher risk for macular edema or at any time you notice vision changes during treatment. Call your healthcare provider right away if you have any of the following symptoms:
blurriness or shadows in the center of your vision
sensitivity to light
a blind spot in the center of your vision
unusually colored vision
swelling and narrowing of blood vessels in your brain. A condition called PRES (Posterior Reversible Encephalopathy Syndrome) is a rare condition that has happened with Zeposia and with drugs in the same class. Symptoms of PRES usually get better when you stop taking Zeposia. If left untreated, it may lead to a stroke.
Your healthcare provider will do a test if you have any symptoms of PRES. Call your healthcare provider right away if you have any of the following symptoms:
sudden severe headache
sudden confusion
sudden loss of vision or other changes in your vision
seizure
severe worsening of multiple sclerosis (MS) after stopping Zeposia. When Zeposia is stopped, symptoms of MS may return and become worse compared to before or during treatment. Always talk to your healthcare provider before you stop taking Zeposia for any reason. Tell your healthcare provider if you have worsening symptoms of MS after stopping Zeposia.
The most common side effects can include:
upper respiratory tract infections
elevated liver enzymes
low blood pressure when you stand up (orthostatic hypotension)
painful and frequent urination (signs of urinary tract infection)
back pain
high blood pressure
headache
These are not all of the possible side effects. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Zeposia side effects (more detail)
How should I store Zeposia?
Store Zeposia at room temperature between 68°F to 77°F (20°C to 25°C).
Keep all medicines out of the reach of children and pets.
General information about the safe and effective use of Zeposia.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not take this medicine for conditions for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your healthcare provider or pharmacist for information that is written for health professionals.
What are the ingredients in Zeposia?
Active ingredient: ozanimod
Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose.
The capsule shell contains: black iron oxide, gelatin, red iron oxide, titanium dioxide, and yellow iron oxide.
