Some medicines can make ciprofloxacin much less effective when taken at the same time. If you take any of the following medicines, take your ciprofloxacin dose 2 hours before or 6 hours after you take the other medicine.
the ulcer medicine sucralfate, or antacids that contain calcium, magnesium, or aluminum (such as Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Tums, and others);
didanosine (Videx) powder or chewable tablets;
vitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.
Tell your doctor about all your other medicines, especially:
clozapine, cyclosporine, methotrexate, phenytoin, probenecid, ropinirole, sildenafil, or theophylline;
a blood thinner (warfarin, Coumadin, Jantoven);
heart medication or a diuretic or "water pill";
oral diabetes medicine;
products that contain caffeine;
medicine to treat depression or mental illness;
steroid medicine (such as prednisone); o
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
This list is not complete. Other drugs may interact with ciprofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Ciprofloxacin drug interactions (more detail)
