Ketoprofen can increase your risk of fatal heart attack or stroke. Do not use  ketoprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ketoprofen may also cause stomach or intestinal bleeding, which can be fatal.
Before taking this medicine
Ketoprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Ketoprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using ketoprofen, especially in older adults.
You should not use ketoprofen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:
heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
a heart attack, stroke, or blood clot;
stomach ulcers or bleeding;
asthma;
liver or kidney disease; or
fluid retention.
If you are pregnant, you should not take ketoprofen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
Ask a doctor before using this medicine if you are breastfeeding.
Ketoprofen is not approved for use by anyone younger than 18 years old.
