Follow all directions on your prescription label. Do not take  Zofran ODT in larger or smaller amounts or for longer than recommended.
Zofran ODT can be taken with or without food.
The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully.
Take the Zofran ODT regular tablet with a full glass of water.
To take the orally disintegrating tablet (Zofran ODT):
Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
Use dry hands to remove the tablet and place it in your mouth.
Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Swallow several times as the tablet dissolves.
To use Zofran ODT soluble film (strip) (Zuplenz):
Keep the strip in the foil pouch until you are ready to use the medicine.
Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away.
Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing.
Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.
Wash your hands after using Zuplenz.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.
 Detailed Zofran ODT dosage information
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.
