Usual Adult Dose for Seizure Prophylaxis:
Initial dose: 1 g orally daily (administered as one 500 mg orally 2 times daily) with or without food
The total daily dose may be increased in 500 mg increments at weekly intervals depending on response.
Recommended dose: 3 g orally daily (1.5 g orally 2 times daily)
A 6 g daily dose has not been shown to confer additional benefit compared to the 3 g daily dose and is associated with an increased incidence of adverse events.
Approved indication: For adults and children 10 years of age and older as adjunctive therapy for refractory complex partial seizures (CPS) who have inadequately responded to several alternative treatments and for whom the potential benefits outweigh the risk of vision loss. Sabril is not indicated as a first line agent for complex partial seizures.
Usual Pediatric Dose for Epilepsy:
Infantile Spasms:
1 month to 2 years of age:
Initial dose: 50 mg/kg/day of vigabatrin oral solution given in two divided doses with or without food. The dose may be titrated by 25 to 50 mg/kg/day increments every 3 days up to a maximum of 150 mg/kg/day.
The entire contents of the appropriate number of packets (500 mg/packet) of powder should be emptied into an empty cup, and should be dissolved in 10 mL of cold or room temperature water per packet using the 10 mL oral syringe supplied with the medication. The concentration of the final solution is 50 mg/mL.
Each individual dose should be prepared immediately before use and administered cold or at room temperature.
Approved indication: As monotherapy for pediatric patients who are 1 month to 2 years of age with infantile spasms (IS) and for whom the potential benefits outweigh the potential risk of vision loss.
Usual Pediatric Dose for Seizure Prophylaxis:
10 to 16 years of age and 25 to 60 kg:
-Initial dose: 500 mg orally daily (administered as one 250 mg orally 2 times daily) with or without food
-Maintenance dose: Total daily dose may be increased at weekly intervals to 2 gm orally daily (1 g orally 2 times daily).
-Patients weighing more than 60 kg should be dosed according to adult guidelines.
Approved indication: For children 10 to 16 years of age as adjunctive therapy for refractory complex partial seizures (CPS) who have inadequately responded to several alternative treatments and for whom the potential benefits outweigh the risk of vision loss. Vigabatrin is not indicated as a first line agent for complex partial seizures.
 Detailed Sabril dosage information
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Call your doctor for instructions if your baby is taking Sabril and misses a dose, takes only part of a dose, or spits up or vomits after taking the medicine.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe drowsiness or dizziness, confusion, trouble speaking, feeling agitated or irritable, unusual thoughts or behavior, increased seizures, slow heart rate, weak or shallow breathing, or fainting.
