Get emergency medical help if you have signs of an allergic reaction to Yosprala: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe nausea, vomiting, stomach pain, or diarrhea that is watery or bloody;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
easy bruising, unusual bleeding (such as a nosebleed), or any bleeding that will not stop;
sudden pain or trouble moving your hip, wrist, or back;
kidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain;
liver problems - stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
low magnesium - dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or
new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.
Taking Yosprala long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.
If you use this medicine for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.
Common Yosprala side effects may include:
heartburn, stomach pain, indigestion;
nausea, diarrhea; or
chest pain (may happen when you eat).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Yosprala side effects (more detail)
