Get emergency medical help if you have signs of an allergic reaction to Duopa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
nausea, vomiting, stomach pain, fever;
ongoing constipation, bloody or tarry stools;
cough, trouble breathing;
pain, swelling, redness, warmth, or oozing around the tube in your stomach wall;
uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
a light-headed feeling, like you might pass out;
chest pain, fast or irregular heartbeats;
daytime sleepiness or if you suddenly fall asleep after being alert;
numbness or weakness in your hands or feet; or
hallucinations, depression or suicidal thoughts.
Some people using Duopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.
You may have increased sexual urges, unusual urges to gamble, or other intense urges. Talk with your doctor if this occurs.
Common Duopa side effects may include:
increased blood pressure;
swelling in your lower legs;
nausea;
depression; or
mouth or throat pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Duopa side effects (more detail)
