Do not give Excedrin to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.
Do not take more Excedrin than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).
Aspirin may cause stomach or intestinal bleeding, which can be fatal. Call your doctor at once if you have symptoms such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
In rare cases, acetaminophen may cause a severe skin reaction. Stop taking Excedrin and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
Before taking this medicine
Do not give Excedrin to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.
You should not use Excedrin if you are allergic to acetaminophen (Tylenol), aspirin, caffeine, or any NSAIDs (Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others).
Aspirin may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are taking Excedrin.
Ask a doctor or pharmacist if it is safe for you to take Excedrin if you have other medical conditions, especially:
liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;
asthma or seasonal allergies;
fever with a stiff neck;
stomach ulcer, stomach or intestinal bleeding, ulcerative colitis;
a bleeding or blood clotting disorder such as hemophilia;
kidney disease; or
if you use medicine to treat glaucoma or prevent blood clots.
If you take Excedrin to treat headache pain, seek medical attention if you have:
a headache so bad you have to lie down;
a headache that causes vomiting;
what feels like the worst headache you've ever had;
a headache that seems different from your usual headaches;
a headache every day;
a headache after coughing, bending, exercising, or head injury;
if you have never had migraines diagnosed by a doctor; or
if you are having your first headache after age 50.
Aspirin may be harmful to an unborn baby's heart, and may also reduce birth weight or have other dangerous effects. Tell your doctor if you are pregnant or plan to become pregnant while you are taking Excedrin.
Aspirin, acetaminophen, and caffeine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Excedrin.
