Some medicines can make ofloxacin much less effective when taken at the same time. If you take any of the following medicines, take your ofloxacin dose 2 hours before or 2 hours after you take the other medicine.
antacids that contain calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate);
didanosine (Videx) powder or chewable tablets; or
vitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.
Tell your doctor about all your other medicines, especially:
theophylline;
a blood thinner (warfarin, Coumadin, Jantoven);
a diuretic or "water pill";
insulin or oral diabetes medicine (check your blood sugar regularly);
heart rhythm medication;
medicine to treat depression or mental illness;
steroid medicine (such as prednisone); or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect ofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Ofloxacin drug interactions (more detail)
