Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. The following medications can interact with BuSpar;
MAO Inihibitors (including isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine as well as methylene blue injection);
Amitriptyline;
Diazepam;
Haloperidol;
Nefazodone;
Trazodone;
Triazolam or flurazepam;
Diltiazem or verapamil;
Antibiotics, including erythromycin and rifampin;
Antifungals, including itraconazole; or
Cimetidine.
In addition, sleeping pills, narcotic pain medicine, muscle relaxers, and other medications for anxiety, depression, or seizures may interact with Buspar.
Other drugs not mentioned here may interact with buspirone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
 BuSpar drug interactions (more detail)
