Get emergency medical help if you have signs of an allergic reaction to lorlatinib: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
sudden chest pain, wheezing, dry cough;
shortness of breath or rapid breathing;
fever, chills, cough with mucus;
sudden dizziness (like you might pass out);
numbness, tingling, or burning pain in your hands or feet;
unusual changes in mood or behavior, thoughts of hurting yourself;
hallucinations; or
problems with speech, thought, or memory.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common lorlatinib side effects may include:
swelling in your arms, hands, legs, or feet;
numbness, tingling, or burning pain in your hands or feet;
mood changes;
feeling tired;
weight gain;
joint pain; or
diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Lorlatinib side effects (more detail)
