You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.
Acetaminophen and tramadol can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder;
opioid medicines;
a benzodiazepine sedative like Valium, Klonopin, or Xanax;
sleep medicine, muscle relaxers, or other drugs that make you drowsy; or</
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drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson's disease.
This list is not complete. Many other drugs may interact with acetaminophen and tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
 Ultracet drug interactions (more detail)
