Do not use Entresto if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Entresto can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
If you have diabetes, do not use Entresto together with any medication that contains aliskiren (Tekturna, Tekamlo).
Before taking this medicine
You should not use Entresto if you are allergic to sacubitril or valsartan (Diovan), or if you have ever had a severe allergic reaction to a blood pressure medication such as:
an ACE inhibitor - benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril (Lotensin, Vasotec, Prinivil, Accupril, Mavik, and others); or
an ARB - azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan (Atacand, Avapro, Benicar, Diovan, Edarbi, Micardis, Teveten, and others).
You should not take Entresto within 36 hours before or after you have taken any ACE inhibitor medication.
If you have diabetes, do not use Entresto together with any medication that contains aliskiren such as Tekturna or Tekamlo.
You may also need to avoid taking Entresto with aliskiren if you have kidney disease.
To make sure Entresto is safe for you, tell your doctor if you have ever had:
liver disease;
diabetes;
hereditary angioedema;
if you are on a low-salt-diet; or
if you are dehydrated.
Do not use Entresto if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Entresto can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.
It is not known whether sacubitril and valsartan passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using Entresto.
How should I take Entresto?
Take Entresto exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take Entresto with or without food. Take the medicine at the same time each day.
Sacubitril and valsartan doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.
If you cannot swallow a tablet whole, a pharmacist can make an oral suspension (liquid). Tell the doctor if the person taking this medicine has trouble swallowing the tablet.
Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Your blood pressure will need to be checked often. Your kidney function may also need to be checked.
Store Entresto in the original container at room temperature away from moisture and heat. Throw away any oral suspension not used within 15 days after it was mixed. Do not keep the oral suspension in a refrigerator.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
