Usual Adult Dose for Parkinson's Disease:
Immediate-release:Initial dose: 0.125 mg orally three times a day Titration: Increase gradually in small dose increments no more frequently than ever 5 to 7 daysMaintenance dose: 1.5 to 4.5 mg per day based on efficacy and tolerabilityMaximum dose: 4.5 mg per dayComment: The following dose titration was used in clinical trials: Week 2, 0.25 mg 3 times a dayWeek 3, 0.5 mg 3 times a dayWeek 4, 0.75 mg 3 times a dayWeek 5, 1 mg 3 times a dayWeek 6, 1.25 mg 3 times a dayWeek 7, 1.5 mg 3 times a day.  -When used in combination with levodopa, the levodopa dose was reduced by an average of 27% from baseline providing a concomitant dose of approximately 800 mg per day.  Extended-release:Initial dose: 0.375 mg orally once a day Titration: Increase gradually no more frequently than every 5 to 7 days, first dose increase should be to 0.75 mg once a day followed by incremental increases of 0.75 mg; assess therapeutic response and tolerability at a minimum of 5 days after each dose increase.Maximum dose: 4.5 mg per day SWITCHING FROM IMMEDIATE-RELEASE TO EXTENDED-RELEASE:-Patients may be switched overnight from immediate-release tablets to extended-release tablets at the same daily dose; monitor closely to determine if dose adjustments may be necessary.Comments:-If a significant interruption in therapy occurs, re-titration may be necessary; upon discontinuation, doses should be tapered.  Use: Treatment of Parkinson's disease
Usual Adult Dose for Restless Legs Syndrome:
Immediate-release:Initial dose: 0.125 mg orally once a day 2 to 3 hours before bedtime Titration: If needed, dose may be titrated upwards by increments of 0.125 mg every 4 to 7 days.Maximum dose: 0.5 mg orally once a day Comments:-Extended-release tablets are not indicated for Restless Legs Syndrome.-Doses of 0.75 mg once a day were used in clinical trials, but were not found to provide additional benefit as compared to the 0.5 mg dose.  Use: For the treatment of moderate to severe primary Restless Legs Syndrome.
 Detailed Pramipexole dosage information
