You should not use metolazone if you are unable to urinate, or if you have severe liver disease.
What should I discuss with my doctor before taking metolazone?
You should not use metolazone if you are allergic to it, or if you have:
severe liver disease; or
if you are unable to urinate.
To make sure metolazone is safe for you, tell your doctor if you have:
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
a heart rhythm disorder;
an allergy to sulfa drugs;
liver disease;
kidney disease;
diabetes;
gout; or
systemic lupus erythematosus.
Using metolazone during pregnancy could cause side effects in the newborn baby, such as blood cell problems, or jaundice (yellowing of the skin or eyes). Tell your doctor if you are pregnant or if you become pregnant while using  metolazone.
Metolazone can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Metolazone is not approved for use by anyone younger than 18 years old.
How should I take metolazone?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Metolazone is usually taken only once per day.
You may need to limit salt in your diet while taking this medicine. Follow your doctor's instructions carefully.
While using metolazone, you may need frequent blood tests. Your blood and urine may both be tested if you have been vomiting or are dehydrated.
Metolazone can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using metolazone.
If you need surgery, tell the surgeon ahead of time that you are using metolazone. You may need to stop using the medicine for a short time.
If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store the tablets at room temperature away from heat, light, and moisture.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe dizziness or drowsiness, dry mouth, thirst, muscle weakness, feeling light-headed, or fainting.
