Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using ibrutinib and call your doctor at once if you have:
severe or ongoing diarrhea;
chest pain, pounding heartbeats or fluttering in your chest, feeling like you might pass out;
severe headache, blurred vision, pounding in your neck or ears;
pale skin, cold hands and feet;
easy bruising or bleeding (nosebleeds, bleeding gums);
signs of bleeding inside your body--dizziness, confusion, problems with speech, prolonged headache, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds;
signs of infection--fever, chills, weakness, mouth sores, cough with mucus, trouble breathing;
kidney problems--little or no urinating, swelling in your feet or ankles; or
signs of tumor cell breakdown--tiredness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth;
Common side effects may include:
diarrhea, nausea;
fever, cough, trouble breathing;
blisters or ulcers in your mouth;
feeling tired;
bruising, rash; or
muscle pain, bone pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Ibrutinib side effects (more detail)
