Get emergency medical help if you have signs of an allergic reaction to Arimidex (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Anastrozole may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries). Seek medical attention if you have new or worsening chest pain, or if you feel short of breath.
Call your doctor at once if you have:
shortness of breath (even with mild exertion), swelling, rapid weight gain;
numbness, prickly feeling, pain, or weakness in your hands or wrists;
symptoms of bone fracture - bruising, swelling, tenderness, pain that worsens with movement;
liver problems - right-sided upper stomach pain, yellowing of your skin or eyes, and not feeling well; or
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
Common Arimidex side effects may include:
numbness, tingling, or tickling feeling in your skin;
hot flashes;
weakness;
joint pain or stiffness;
bone pain, risk of fracture;
swelling in your arms, legs, or feet;
sore throat, cough, shortness of breath;
headache, back pain;
depression, sleep problems (insomnia);
high blood pressure;
nausea, vomiting; or
rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Arimidex side effects (more detail)
