Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many other drugs (including some over-the-counter medicines) can increase your risk of bleeding or blood clots, or your risk of developing blood clots around the brain or spinal cord during a spinal tap or epidural. It is very important to tell your doctor about all medicines you have recently used, especially:
any other medicines to treat or prevent blood clots;
a blood thinner such as heparin or warfarin (Coumadin, Jantoven);
an antidepressant (including selective serotonin reuptake inhibitors or SSRI drugs); or
an NSAID (nonsteroidal anti-inflammatory drug) used long term.
This list is not complete and many other drugs may interact with apixaban. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Eliquis drug interactions (more detail)
