Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Call your doctor at once if the person taking this medicine has signs of liver or pancreas problems, such as: loss of appetite, upper stomach pain (that may spread to your back), ongoing nausea or vomiting, dark urine, swelling in the face, or jaundice (yellowing of the skin or eyes).
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these other side effects:
easy bruising, unusual bleeding (nose, mouth, or gums), purple or red pinpoint spots under your skin;
fever, swollen glands, mouth sores;
confusion, tiredness, cold feeling, vomiting, change in your mental state;
severe drowsiness; or
worsening seizures.
Common side effects may include:
nausea, vomiting, stomach pain, diarrhea, constipation;
headache, back pain;
dizziness, drowsiness, weakness, tremors;
memory problems, mood changes, trouble sleeping;
bruising or bleeding;
runny nose, sore throat, cough, wheezing, trouble breathing;
fever, flu symptoms;
problems with walking or coordination;
swelling in your hands or feet;
blurred vision, double vision, unusual eye movements;
ringing in your ears;
rash, hair loss; or
changes in weight or appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Divalproex sodium side effects (more detail)
