Get emergency medical help if you have signs of an allergic reaction to Kombiglyze XR: hives, itching, peeling skin; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop taking this medicine and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.
Some people using metformin develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:
unusual muscle pain;
feeling cold;
trouble breathing;
feeling dizzy, light-headed, tired, or very weak;
stomach pain, vomiting; or
irregular heart rate.
Call your doctor at once if you have any of these serious side effects:
severe autoimmune reaction - itching, blisters, breakdown of the outer layer of skin;
severe or ongoing pain in your joints;
pain or burning when you urinate; or
symptoms of heart failure - shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.
Common Kombiglyze XR side effects may include:
diarrhea, nausea;
headache; or
cold symptoms such as runny or stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Kombiglyze XR side effects (more detail)
