Before you receive Xiaflex, tell your doctor if you have a bleeding or blood clotting disorder, such as hemophilia.
Xiaflex can damage a nerve, tendon, or ligament in the hand the medicine is injected into. After the swelling from your injection goes down, call your doctor if you have numbness, tingling, increased pain, trouble bending your finger toward your wrist, or if you have new or worsened movement problems in your treated hand.
Xiaflex may also damage the erectile tissues inside a man's penis, which could require surgery to correct. Call your doctor right away if you have bruising and swelling of your penis, pain when you urinate, blood in the urine, sudden erection problems, or a "popping" sound or sensation in your penis during an erection.
Before receiving this medicine
You should not use Xiaflex if you are allergic to collagenase clostridium histolyticum. Xiaflex should not be used to treat Peyronie's disease that affects the urethra (the tube for passing urine out of your bladder).
To make sure Xiaflex is safe for you, tell your doctor if you have:
a bleeding or blood clotting disorder, such as hemophilia; or
if you take a blood thinner such as warfarin (Coumadin, Jantoven).
FDA pregnancy category B. Xiaflex is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether collagenase clostridium histolyticum passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby while using Xiaflex.
 Xiaflex pregnancy and breastfeeding warnings (more detail)
