You should not use Janumet if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin).
Janumet may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Janumet may also lead to a serious condition called pancreatitis. Call your doctor right away if you have severe stomach pains with or without vomiting.
Before taking this medicine
You should not use Janumet if you are allergic to metformin or sitagliptin (Januvia), or if you have severe kidney disease.
To make sure Janumet is safe for you, tell your doctor if you have ever had:
kidney disease (your kidney function may need to be checked before and while you are taking this medicine);
liver disease;
heart disease;
pancreatitis;
high triglycerides (a type of fat in the blood);
gallstones; or
alcoholism.
Some people taking metformin develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney disease, congestive heart failure, surgery, a heart attack or stroke, a severe infection, if you are 65 or older, if you are dehydrated, or if you drink a lot of alcohol. Talk with your doctor about your risk.
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Janumet. Be sure your caregivers know ahead of time that you are using this medication.
Follow your doctor's instructions about using Janumet if you are pregnant or you become pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy. Having high blood sugar may cause complications in both the mother and the baby.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Your dose needs may also be different while you are breastfeeding.
Janumet is not approved for use by anyone younger than 18 years old.
