You will need frequent medical tests before and during treatment with Jynarque.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
You should not use Jynarque if you are dehydrated or unable to urinate, or if you can't tell when you are thirsty.
You also should not use Jynarque if you have ever had liver problems (other than polycystic liver disease), or if your sodium blood level is too high or too low.
Samsca is given to treat low levels of sodium in your blood, but can be dangerous if this condition is reversed too quickly. Tell your caregivers at once if you have problems with speech or muscle control, trouble swallowing, trouble moving your arms and legs, confusion, or seizure.
Jynarque can cause serious or fatal liver problems. Call your doctor right away if you don't feel well and you have right-sided upper stomach pain, vomiting, loss of appetite, or yellowing of your skin or eyes.
Before taking this medicine
You should not use Jynarque if you are allergic to it, or if:
you are unable to urinate;
you are unable to tell that you are thirsty; or
you are severely dehydrated and feel like you might pass out.
Samsca is not for use in people with autosomal dominant polycystic kidney disease (unless you receive Samsca through a special program that includes frequent liver function tests).
You should not take Samsca if your sodium level needs to be increased quickly.
You should not take Jynarque if you've been told that your sodium blood level is too high or too low.
Some medicines can cause unwanted or dangerous effects when used with Jynarque. Your doctor may change your treatment plan if you also use:
nefazodone;
an antibiotic--clarithromycin, telithromycin;
antifungal medicine--itraconazole, ketoconazole; or
HIV/AIDS medication--indinavir, nelfinavir, ritonavir, saquinavir.
Tell your doctor if you have ever had:
kidney disease or urination problems;
liver problems;
allergies;
if you drink large amounts of alcohol;
if you are malnourished; or
if you also use desmopressin (dDAVP), or a diuretic or "water pill."
It is not known whether  Jynarque will harm an unborn baby. Tell your doctor if you are pregnant.
You should not breastfeed while using Jynarque.
