You should not use this medicine if you have a stomach ulcer, severe liver disease, porphyria, a bleeding or blood clotting disorder, or if you are allergic to any NSAID.
Aspirin may cause stomach or intestinal bleeding, which can be fatal.
Stop using Butalbital Compound and call your doctor at once if you have: black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.
Aspirin should not be given to a child or teenager who has a fever.
Butalbital may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.
Before taking this medicine
Aspirin may cause stomach or intestinal bleeding, which can be fatal. This can occur without warning while you are taking  Butalbital Compound.
You should not use this medicine if you are allergic to aspirin, butalbital, or caffeine, or if you have:
stomach ulcer;
severe liver disease;
porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
a bleeding or blood clotting disorder (such as hemophilia); or
asthma, or a history of severe allergic reaction (sneezing, runny or stuffy nose, wheezing, shortness of breath) after taking aspirin or another NSAID (nonsteroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Celebrex, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.
To make sure Butalbital Compound is safe for you, tell your doctor if you have:
liver or kidney disease;
asthma or another respiratory disease;
fluid retention;
heart disease, congestive heart failure, high blood pressure;
a history of head injury or brain tumor;
a stomach or intestinal disorder;
a thyroid disorder;
enlarged prostate or urination problems; or
Addison's disease (an adrenal gland disorder).
It is not known whether this medicine will harm an unborn baby. If you use butalbital while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.
Aspirin, butalbital, and caffeine can pass into breast milk and may harm a nursing baby. Aspirin use while breast-feeding could cause bleeding in the infant. You should not breast-feed while using this medicine.
Do not give this medicine to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.
