You should not take mirtazapine if you are also taking tryptophan (sometimes called L-tryptophan).
Do not use mirtazapine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine and others.
Some people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using mirtazapine. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. This medicine is not approved for use in children.
It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.
Drinking alcohol can increase certain side effects of mirtazapine.
Mirtazapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Do not stop taking this medicine abruptly. Talk to your doctor before stopping this medicine.
Before taking this medicine
You should not take this medicine if you are allergic to mirtazapine.
Do not use mirtazapine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
low white blood cell counts;
glaucoma;
liver or kidney disease;
low sodium levels in your blood;
a seizure;
depression, suicidal thoughts or actions;
bipolar disorder (manic depression) in you or a family member;
heart problems or stroke;
high cholesterol or triglycerides;
long QT syndrome (in you or a family member); or
low blood pressure.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with mirtazapine and cause a serious condition called serotonin syndrome.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Tell your doctor if you are pregnant or breastfeeding.
The orally disintegrating tablet may contain phenylalanine and could be harmful if you have phenylketonuria (PKU).
Mirtazapine is not approved for use by anyone younger than 18 years old.
How should I take mirtazapine?
Take mirtazapine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Take the medicine at the same time each day, usually at bedtime.
Take the regular tablet form of mirtazapine with water.
You may take mirtazapine with or without food.
Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet on your tongue and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves.
It may take a few weeks for your symptoms to improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.
Do not stop using mirtazapine suddenly, or you could have unpleasant symptoms (such as dizziness, vomiting, agitation, sweating, confusion, numbness, tingling, or electric shock feelings). Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture, heat, and light.
