Get emergency medical help if you have signs of an allergic reaction to buprenorphine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
opioid withdrawal symptoms - shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain;
noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
slow heartbeat or weak pulse;
a light-headed feeling, like you might pass out;
chest pain, trouble breathing;
low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
liver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common buprenorphine side effects may be more likely to occur, such as:
constipation, nausea, vomiting;
headache;
increased sweating;
sleep problems (insomnia); or
pain anywhere in your body.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Buprenorphine side effects (more detail)
