Usual Adult Dose of Orencia for Rheumatoid Arthritis:
IV:
-Less than 60 kg, give 500 mg
-If 60 to 100 kg, give 750 mg
-If greater than 100 kg, give 1000 mg
Administer once as a 30-minute IV infusion. The dose is repeated 2 and 4 weeks after the initial dose, then every 4 weeks thereafter. It may be administered alone or with disease-modifying antirheumatic drugs other than TNF antagonists.
SUBCUTANEOUS:
-After a single IV infusion as a loading dose (as per body weight categories above), 125 mg administered by subcutaneous injection should be given within a day, followed by 125 mg subcutaneously once a week.
-Patients who are unable to receive an infusion may initiate weekly injections subcutaneously without an IV loading dose.
-Patients transitioning from IV therapy to subcutaneous administration should administer the first subcutaneous dose instead of the next scheduled IV dose.
Comments:
-This drug should not be administered concomitantly with TNF antagonists or used concomitantly with other biologic rheumatoid arthritis (RA) therapy, such as anakinra.
Use: For reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis. This drug may be used as monotherapy or concomitantly with disease-modifying antirheumatic drugs (DMARDs) other than tumor necrosis factor (TNF) antagonists.
Usual Pediatric Dose of Orencia for Juvenile Idiopathic Arthritis:
IV:
6 to 17 years:
If less than 75 kg, give 10 mg/kg IV
75 kg to 100 kg, give 750 mg IV
If greater than 100 kg, give 1000 mg IV
-The maximum dose per intravenous administration should not exceed 1000 mg.
-Administer once as a 30-minute IV infusion. The dose is repeated 2 and 4 weeks after the initial dose, then every 4 weeks thereafter. It may be administered alone or concomitantly with methotrexate.
SUBCUTANEOUS:
2 years and older:
The subcutaneous injection should be given without an IV loading dose:
10 kg to less than 25 kg: 50 mg subcutaneously once a week
25 kg to less than 50 kg: 87.5 mg subcutaneously once a week
50 kg or more: 125 mg subcutaneously once a week
Comments:
-This drug should not be administered concomitantly with TNF antagonists or used concomitantly with other biologic rheumatoid arthritis (RA) therapy, such as anakinra.
-The safety and efficacy of the auto-injector for subcutaneous injection has not been studied in patients under 18 years of age.
Use: For reducing signs and symptoms in pediatric patients 2 years of age and older with moderately to severely active polyarticular juvenile idiopathic arthritis. This drug may be used as monotherapy or concomitantly with methotrexate (MTX).
 Detailed Orencia dosage information
What happens if I miss a dose?
Call your doctor for instructions if you miss your Orencia dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
