Using spironolactone with other drugs that make you dizzy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your other medicines, especially:
colchicine;
digoxin;
lithium;
loperamide;
trimethoprim;
heart or blood pressure medicine (especially another diuretic);
medicine to prevent a blood clot; or
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Spironolactone drug interactions (more detail)
