You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.
Buprenorphine can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic ("water pill");
medicines for motion sickness, irritable bowel syndrome, or overactive bladder;
other narcotic medications - opioid pain medicine or prescription cough medicine;
a sedative like Valium - diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;
drugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or
drugs that affect serotonin levels in your body - a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may interact with buprenorphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
 Buprenorphine drug interactions (more detail)
Alternatives to buprenorphine
Buprenorphine is available in different dosage forms and there are other alternative drugs used to treat opioid use disorder or severe pain. Talk with your healthcare provider which option would be best suited to you
Medicines used to treat opioid addiction:
Buprenorphine:
Subcutaneous injection, abdominal (Sublocade);
Implant (Probuphine);
Sublingual tablets (Subutex).
Buprenorphine and naloxone
Sublingual film (Bunavail);
Sublingual film and sublingual tablets (Suboxone);
Sublingual tablets (Zubsolv).
Lofexidine
Tablets (Lucemyra).
Naltrexone
IM injection (Vivitrol);
Tablets (Naltrexone).
For opioid overdose in an emergency situation:
Naloxone
Nasal spray (Narcan, Kloxxado);
Naloxone injection.
Medicines used to treat severe pain:
Buprenorphine:
IM and IV injection (Buprenex);
Buccal film (Belbuca);
Transdermal patch (Butrans).
There are other groups of pain relieving medicines (including narcotic analgesics).
Medicine to treat opioid addiction or moderate to severe pain:
Methadone
Tablets (Dolophine).
