Leflunomide can cause severe or fatal liver damage. This effect is increased when you also use certain other medicines, including:
acetaminophen (Tylenol), aspirin, gout or arthritis medication (including gold injections); an NSAID (non-steroidal anti-inflammatory drug)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
an antibiotic, antifungal medicine, or sulfa drug; tuberculosis medicine; antiviral or HIV/AIDS medication; medicine to treat mental illness; seizure medication--carbamazepine, phenytoin, valproic acid, and others;
birth control pills or hormone replacement therapy; anabolic steroids--methyltestosterone, "performance-enhancing drugs"; cancer medication; or
cholesterol-lowering medication--Crestor, Lipitor, Vytorin, Zocor, and others; heart or blood pressure medication.
This list is not complete and many other drugs can interact with leflunomide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. Not all possible interactions are listed in this medication guide.
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