Some drugs can make this medicine less effective, which may result in pregnancy. Use a barrier form of birth control (condom, diaphragm, cervical cap, contraceptive sponge) if you also take:
aprepitant, bosentan, griseofulvin, rifabutin, rifampin, St. John's wort;
antiviral medicine to treat HIV--nelfinavir, nevirapine, ritonavir; or
seizure medicine--carbamazepine, felbamate, oxcarbazepine, phenobarbital, phenytoin, rufinamide, or topiramate.
Many other drugs can affect  Xulane, especially:
acetaminophen, ascorbic acid (vitamin C), lamotrigine, levothyroxine;
antifungal medicine--fluconazole, itraconazole, ketoconazole, voriconazole;
certain HIV medicines--atazanavir, etravirine, indinavir; or
cholesterol medicine--atorvastatin, rosuvastatin.
This list is not complete and many other drugs may affect Xulane. Tell your doctor about all your current medicines. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Xulane drug interactions (more detail)
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