Usual Adult Dose for Lymphoma:
2 x 10(6) chimeric antigen receptor (CAR)-positive viable T cells IV per kg body weight via IV infusion; infuse within 30 minutes
Maximum Dose: 2 x 10(8) CAR-positive viable T cells
Comments:
-Pretreatment: Administer a lymphodepleting chemotherapy regimen of cyclophosphamide 500 mg/m2 IV and fludarabine 30 mg/m2 IV on the fifth, fourth, and third day before infusion of this drug.
-Premedication: Administer acetaminophen 650 mg orally and diphenhydramine 12.5 mg IV or orally approximately 1 hour before infusion of this drug.
-Avoid prophylactic use of systemic corticosteroids as it may interfere with the activity of this drug.
Use: Treatment of relapsed or refractory large B-cell lymphoma after 2 or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma
 Detailed Yescarta dosage information
What happens if I miss a dose?
Call your doctor for instructions if you miss any of your chemotherapy treatment, or if you miss a dose of your medications to prevent side effects of axicabtagene ciloleucel.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
