Do not use if you are pregnant. If you become pregnant, stop taking  hydrochlorothiazide and lisinopril and tell your doctor right away.
You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (a blood pressure medicine).
Before taking this medicine
You should not use this medicine if you are allergic to hydrochlorothiazide or lisinopril, or if:
you have hereditary angioedema;
you are unable to urinate;
you recently took a heart medicine called sacubitril;
you have an allergy to sulfa drugs; or
you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, ramipril, trandolapril).
Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking hydrochlorothiazide and lisinopril with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
cirrhosis or other liver disease;
glaucoma;
heart disease or congestive heart failure;
asthma or allergies;
gout;
lupus;
an allergy to sulfa drugs or penicillin; or
if you are on a low-salt diet.
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Lisinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while using hydrochlorothiazide and lisinopril.
Hydrochlorothiazide and lisinopril is not approved for use by anyone younger than 18 years old.
How should I take hydrochlorothiazide and lisinopril?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking  hydrochlorothiazide and lisinopril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
Your blood pressure will need to be checked often, and you may need occasional blood tests.
If you need surgery, tell your surgeon you currently use this medicine.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
