Get emergency medical help if you have signs of an allergic reaction to Yondelis: hives; chest tightness, wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.
Capillary leak syndrome is a rare but serious side effect of trabectedin. Tell your doctor right away if you have signs of this condition: stuffy or runny nose followed by weakness or tired feeling, and sudden swelling in your arms, legs and other parts of the body.
Call your doctor at once if you have:
pain, burning, irritation, or skin changes where the injection was given;
heart problems - chest pain, fast or pounding heartbeats, shortness of breath (even with mild exertion), swelling, rapid weight gain;
breakdown of muscle tissue - unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine);
liver problems - nausea, upper stomach pain, confusion, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
low blood cell counts - fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common Yondelis side effects may include:
nausea, vomiting, loss of appetite;
diarrhea, constipation;
swelling, tiredness;
low blood cell counts;
abnormal liver or kidney function tests;
headache; or
feeling short of breath.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Yondelis side effects (more detail)
