Get emergency medical help if you have signs of an allergic reaction to Epidiolex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have symptoms of liver problems, such as:
nausea, vomiting, loss of appetite;
tiredness, not feeling well;
right-sided upper stomach pain;
itching;
dark urine; or
jaundice (yellowing of the skin or eyes).
Common Epidiolex side effects may include:
drowsiness;
changes in appetite or weight;
feeling weak or tired;
infections (fever, flu symptoms, cough, swelling, redness, itching);
diarrhea;
sleep problems (insomnia);
rash; or
abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Epidiolex side effects (more detail)
