Taking tizanidine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your other medicines, especially:
acyclovir;
ticlopidine;
zileuton;
birth control pills;
an antibiotic - ciprofloxacin, levofloxacin, moxifloxacin, or ofloxacin;
blood pressure medicine - clonidine, guanfacine, methyldopa;
heart rhythm medicine - amiodarone, mexiletine, propafenone, verapamil; or
stomach acid medicine - cimetidine, famotidine.
This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
 Tizanidine drug interactions (more detail)
