Get emergency medical help if you have signs of an allergic reaction to Rexulti: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
High doses or long-term use of Rexulti can cause a serious movement disorder that may not be reversible. The longer you use this medicine, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.
Call your doctor at once if you have:
uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
trouble swallowing;
feelings of warmth, intolerance to heat;
a seizure (convulsions);
a light-headed feeling, like you might pass out;
high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor;
low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing;
severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors; or
signs of a blood clot - sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.
Common Rexulti side effects may include:
weight gain; or
feeling restless or being unable to sit still.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Rexulti side effects (more detail)
