Usual Adult Dose for Opiate Dependence - Maintenance:
For use in opioid-tolerant patients who meet ALL of the following criteria:
-Achieved and sustained prolonged clinical stability on transmucosal buprenorphine as evidenced by a stable dose for 3 months or longer without any need for supplemental dosing or dose adjustments.
-Currently receiving buprenorphine maintenance (with or without naloxone) at doses of 8 mg/day or less, or equivalent transmucosal product (e.g. Bunavail buprenorphine 4.2 mg/naloxone 0.7 mg per day or less; or Zubsolv buprenorphine 5.7 mg/naloxone 1.4 mg per day or less)
-Patients should not be tapered to a lower dose for the sole purpose of transitioning to the implant.
Insert 1 dose subdermally in the inner side of the upper arm
-Remove at the end of the sixth month
Comments:
-Probuphine implant insertions and removals should be performed by certified healthcare providers.
-Each dose consists of 4 implants; each implant contains 74.2 mg of buprenorphine
-After 1 insertion in each arm, most patients should be transitioned back to transmucosal products for continued treatment as there is no experience with inserting additional implants into other sites in the arm or into a previously-used site.
Uses: For the treatment of opioid dependence as part of a complete treatment plan to include counseling and psychosocial support. There is no maximum recommended duration for maintenance therapy as indefinite treatment may be required; when the decision is made to discontinue, doses should be tapered.
 Detailed Probuphine dosage information
What happens if I miss a dose?
As Probuphine implants are implanted under your skin, low-level doses of buprenorphine will be continuously delivered into your body for up to 6 months, it is unlikely you will miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of buprenorphine can be fatal.
Overdose symptoms may include severe drowsiness, pinpoint pupils, weak or shallow breathing, or loss of consciousness.
