Tell your doctor about all your other medicines, especially:
an antibiotic or sulfa drug;
folic acid;
mercaptopurine;
theophylline;
NSAIDs> (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
stomach acid reducers - esomeprazole, lansoprazole, omeprazole, pantoprazole, Nexium, Prilosec, Protonix, and others.
Many drugs can interact with methotrexate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
 Methotrexate drug interactions (more detail)
