You should not use Nuedexta if you have heart failure, a serious heart condition called "AV block" (unless you have a pacemaker), or a history of Long QT syndrome or life-threatening heart rhythm disorder.
Do not use Nuedexta if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
You also should not take Nuedexta if you are also taking mefloquine, quinidine, or quinine, or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications.
Some medicines can interact with Nuedexta and should not be used at the same time. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine.
You should not take Nuedexta if you are also taking quinidine (Quin-G), quinine (Qualaquin), or mefloquine (Lariam), or if you have ever had an allergic reaction or serious medical problem caused by taking any of these medications.
Before taking this medicine
You should not take Nuedexta if you are allergic to dextromethorphan or quinidine, or if you have:
heart failure;
a history of life-threatening heart rhythm disorder;
long QT syndrome (in you or a family member);
a serious heart condition called "AV block" (unless you have a pacemaker); or
if you also use mefloquine, quinidine, or quinine.
You also should not take Nuedexta if you have ever had any of the following problems caused by taking mefloquine, quinidine, or quinine:
bruising or bleeding;
hepatitis;
an allergic reaction; or
lupus-like symptoms (joint pain, fever, skin rash on your cheeks).
Do not use Nuedexta if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. After you stop taking Nuedexta, you must wait at least 14 days before you start taking an MAOI.
Nuedexta can cause a serious heart problem. You should not take this medicine if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with dextromethorphan and quinidine and cause a serious condition called serotonin syndrome.
To make sure Nuedexta is safe for you, tell your doctor if you have ever had:
heart disease, high blood pressure, coronary artery disease;
slow heartbeats or any type of heart rhythm disorder;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
myasthenia gravis; or
trouble with balance or walking.
Tell your doctor if you are pregnant or breastfeeding.
Nuedexta is not approved for use by anyone younger than 18 years old.
How should I take Nuedexta?
Take Nuedexta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Nuedexta is usually taken once per day for 7 days, and then once every 12 hours. Follow your doctor's dosing instructions very carefully.
You may take Nuedexta with or without food.
Your doctor will need to check your progress on a regular basis. You may need medical tests to help your doctor determine how long to treat you with Nuedexta.
Store at room temperature away from moisture and heat.
