Tremfya can weaken (suppress) your immune system, and you may get an infection more easily.
Call your doctor if you have signs of infection such as fever, sweats, chills, muscle aches, weight loss, severe diarrhea, stomach cramps, pain or burning when you urinate, cough (may contain blood or mucus), shortness of breath, or skin sores that look different from psoriasis.
Before taking this medicine
You should not use Tremfya if you are allergic to guselkumab or Polysorbate 80.
Tell your doctor if you have ever had tuberculosis, or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.
Before you start treatment with Tremfya, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
To make sure Tremfya is safe for you, tell your doctor if you have:
an active or chronic infection;
active tuberculosis infection that is not being treated; or
if you have recently received or are scheduled to receive any vaccine.
Make sure you are current on all vaccines before you start treatment with Tremfya.
It is not known whether guselkumab will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of guselkumab on the baby.
It is not known whether guselkumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breastfeeding.
Tremfya is not approved for use by anyone younger than 18 years old.
How should I use Tremfya?
Use Tremfya exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Tremfya is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.
The first two injections are usually given 4 weeks apart, followed by one injection every 8 weeks. Your doctor will determine how long to treat you with guselkumab.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand all instructions.
Store this medicine in the refrigerator. Protect from light and do not freeze.
Take the medicine out of the refrigerator and allow it to reach room temperature for 30 minutes before injecting your dose. Do not remove the needle cap until you are ready to give the injection.
Do not shake the prefilled syringe. Prepare your dose only when you are ready to give an injection.
Tremfya should appear clear to light yellow in color. Do not use the medicine if it looks cloudy or has particles in it. Call your pharmacist for new medicine.
Do not inject Tremfya into an active psoriasis lesion. Avoid injecting into skin that is thick, scaly, bruised, red, or tender.
Each One-Press injector or prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
