Usual Adult Dose for Pulmonary Embolism:
Initial dose: 4400 international units/kg IV at a rate of 90 mL/hr over 10 minutesMaintenance dose: 4400 international units/kg/hr IV at a rate of 15 mL for 12 hoursComments:-Institute treatment soon after onset of pulmonary embolism to avoid potential decrease in efficacy.-Administration of this drug may be repeated as necessary.-After infusing this drug, do not begin anticoagulation until activated partial thromboplastin time (aPTT) has decreased to less than twice the normal control value; if heparin is used, do not administer a loading dose of heparin; treatment should be followed by oral anticoagulants.Uses:-Lysis of acute massive pulmonary emboli (obstruction of blood flow to a lobe or multiple segments).-Lysis of pulmonary emboli accompanied by unstable hemodynamics (e.g., failure to maintain blood pressure without supportive measures).
 Detailed Urokinase dosage information
