You should not use  zolmitriptan if you have uncontrolled high blood pressure, heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Do not use zolmitriptan within 24 hours before or after using another migraine headache medicine.
Before taking this medicine
You should not use zolmitriptan if you are allergic to it, or if you have:
coronary heart disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart;
a history of heart disease, heart attack, or stroke, including "mini-stroke";
Wolff-Parkinson-White syndrome;
severe or uncontrolled high blood pressure;
a blood vessel disorder or circulation problems that cause a lack of blood supply within the body; or
a headache that seems different from your usual migraines.
Do not use zolmitriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
To make sure zolmitriptan is safe for you, tell your doctor if you have:
heart disease, high blood pressure, or a heart rhythm disorder;
epilepsy or seizures;
liver or kidney disease;
a condition for which you take cimetidine (Tagamet); or
coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
Zolmitriptan disintegrating tablets may contain phenylalanine. Talk to your doctor before using this form of zolmitriptan if you have phenylketonuria (PKU).
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether zolmitriptan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Zolmitriptan is not approved for use by anyone younger than 18 years old.
