Usual Adult Dose for Lennox-Gastaut Syndrome:
Initial dose: 2.5 mg/kg orally twice a day
-After 1 week, may increase dose to 5 mg/kg orally twice a day
-For patients tolerating therapy and requiring further seizure reduction, may increase in 2.5 mg/kg twice a day increments as tolerated but no more frequently than every other day
Maintenance dose: 10 to 20 mg/kg/day
Maximum dose: 20 mg/kg/day
Comments:
-A dose of 20 mg/kg/day has demonstrated a greater reduction in seizure rates, but is associated with an increase in adverse reactions.
-Consistent dosing with respect to meals is recommended to reduce variability in cannabidiol plasma exposure.
Use: For the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome.
Usual Adult Dose for Dravet Syndrome:
Initial dose: 2.5 mg/kg orally twice a day
-After 1 week, may increase dose to 5 mg/kg orally twice a day
-For patients tolerating therapy and requiring further seizure reduction, may increase in 2.5 mg/kg twice a day increments as tolerated but no more frequently than every other day
Maintenance dose: 10 to 20 mg/kg/day
Maximum dose: 20 mg/kg/day
Comments:
-A dose of 20 mg/kg/day has demonstrated a greater reduction in seizure rates, but is associated with an increase in adverse reactions.
-Consistent dosing with respect to meals is recommended to reduce variability in cannabidiol plasma exposure.
Use: For the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome.
Usual Adult Dose for Tuberous Sclerosis Complex:
Initial dose: 2.5 mg/kg orally twice a day
-Increase dose in weekly increments of 2.5 mg twice a day (5 mg/kg/day) as tolerated to 12.5 mg/kg twice a day
-For patients requiring a more rapid titration, the dose may be increased no more frequently than every other day
Maintenance dose: 25 mg/kg/day
Maximum dose: 25 mg/kg/day
Comments:
-The effectiveness of doses lower than 25 mg/kg/day has not been studied.
-Consistent dosing with respect to meals is recommended to reduce variability in cannabidiol plasma exposure.
Use: For the treatment of seizures associated with tuberous sclerosis complex.
Usual Pediatric Dose for Lennox-Gastaut Syndrome:
1 year or older:
Initial dose: 2.5 mg/kg orally twice a day
-After 1 week, may increase dose to 5 mg/kg orally twice a day
-For patients tolerating therapy and requiring further seizure reduction, may increase in 2.5 mg/kg twice a day increments as tolerated but no more frequently than every other day
Maintenance dose: 10 to 20 mg/kg/day
Maximum dose: 20 mg/kg/day
Comments:
-A dose of 20 mg/kg/day has demonstrated a greater reduction in seizure rates, but is associated with an increase in adverse reactions.
-Consistent dosing with respect to meals is recommended to reduce variability in cannabidiol plasma exposure.
Use: For the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 1 year and older.
Usual Pediatric Dose for Dravet Syndrome:
1 year or older:
Initial dose: 2.5 mg/kg orally twice a day
-After 1 week, may increase dose to 5 mg/kg orally twice a day
-For patients tolerating therapy and requiring further seizure reduction, may increase in 2.5 mg/kg twice a day increments as tolerated but no more frequently than every other day
Maintenance dose: 10 to 20 mg/kg/day
Maximum dose: 20 mg/kg/day
Comments:
-A dose of 20 mg/kg/day has demonstrated a greater reduction in seizure rates, but is associated with an increase in adverse reactions.
-Consistent dosing with respect to meals is recommended to reduce variability in cannabidiol plasma exposure.
Use: For the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 1 year and older.
Usual Pediatric Dose for Tuberous Sclerosis Complex:
1 year or older:
Initial dose: 2.5 mg/kg orally twice a day
-Increase dose in weekly increments of 2.5 mg twice a day (5 mg/kg/day) as tolerata to 12.5 mg/kg twice a day
-For patients requiring a more rapid titration, the dose may be increased no more frequently than every other day
Maintenance dose: 25 mg/kg/day
Maximum dose: 25 mg/kg/day
Comments:
-The effectiveness of doses lower than 25 mg/kg/day has not been studied.
-Consistent dosing with respect to meals is recommended to reduce variability in cannabidiol plasma exposure.
Use: For the treatment of seizures associated with tuberous sclerosis complex in patients 1 year and older.
 Detailed Epidiolex dosage information
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
