Taking isosorbide mononitrate with certain other medicines can cause severely low blood pressure. This includes medicine to treat erectile dysfunction or pulmonary arterial hypertension. Serious, life-threatening side effects may occur.
Tell your doctor about all your current medicines and any you start or stop using, especially:
erectile dysfunction medication (including Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil, others);
a diuretic or "water pill";
blood pressure medications including calcium channel blockers (such as nifedipine, Procardia);
nitroglycerin; or
riociguat (Adempas);
This list is not complete. Other drugs may interact with isosorbide mononitrate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
 Isosorbide mononitrate drug interactions (more detail)
