Juvisync is a combination medicine for people with type 2 diabetes who also have high cholesterol.
You should not use Juvisync if you have liver disease or severe kidney disease. Do not use if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Do not use Juvisync if you are pregnant, and stop taking the medicine if you become pregnant.
Do not use this medicine if you are breast-feeding.
Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor if you have severe pain in your upper stomach spreading to your back.
There are many other drugs that should not be used together with Juvisync. Tell your doctor about all other medicines you use. Do not consume grapefruit products while taking this medicine.
Before taking this medicine
You should not use Juvisync if you are allergic to simvastatin or sitagliptin, or if you have:
liver disease;
severe kidney disease;
if you are pregnant or breast-feeding; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
There are many other drugs that should not be used together with this medicine. Some medicines can cause unwanted or dangerous effects when used with Juvisync. Your doctor may need to change your treatment plan if you use any of the following drugs:
cyclosporine;
danazol;
gemfibrozil;
nefazodone;
certain antibiotics--clarithromycin, erythromycin, or telithromycin;
certain antifungal medications--itraconazole, ketoconazole, posaconazole, or voriconazole;
the hepatitis C medications boceprevir or telaprevir; or
certain HIV/AIDS medications--atazanavir, cobicistat (Stribild, Tybost), indinavir, nelfinavir, ritonavir, saquinavir, or tipranavir.
To make sure Juvisync is safe for you, tell your doctor if you have:
a history of liver or kidney disease;
a history of pancreatitis;
a history of gallstones;
high triglycerides (a type of fat in the blood);
underactive thyroid;
a history of alcoholism, or if you drink large amounts of alcohol; or
if you use a blood thinner such as warfarin (Coumadin, Jantoven).
This medicine can harm an unborn baby or cause birth defects. Do not take Juvisync if you are pregnant. Stop taking the medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking Juvisync.
It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are taking Juvisync.
Do not give this medication to anyone under 18 years old without medical advice.
