Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:
Dosing is based on actual body weight; premedication should be given at least 60 minutes prior to the start of the infusion
Weight less than 100 kg: 0.3 mg/kg via IV infusion every 3 weeks
Weight 100 kg or greater: 30 mg via IV infusion every 3 weeks
Initial infusion rate should be approximately 1 mL/min for the first 15 minutes, then increase to approximately 3 mL/min for the remainder of the infusion; in the event of an infusion related reaction, the duration of infusion may be extended; see administration advice for infusion instructions
PREMEDICATION: Administer on day of infusion at least 60 minutes prior to start of infusion:
-Acetaminophen 500 mg orally
-IV corticosteroid (e.g., dexamethasone 10 mg or equivalent)
-IV H1 blocker (e.g. diphenhydramine 50 mg or equivalent)
-IV H2 blocker (e.g., ranitidine 50 mg or equivalent)
Comments:
-Premedications are required to reduce the risk of infusion related reactions (IRR).
-If IV premedications are not available or not tolerated, oral equivalents may be used
-If patients are tolerating the infusion, but experiencing adverse reactions to corticosteroid premedication, reduce corticosteroid in 2.5 mg increments to a minimum IV dose of dexamethasone 5 mg or equivalent
-Some patients may require additional or higher doses of one or more premedications to reduce the risk of IRRs.
Use: For the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis.
 Detailed Onpattro dosage information
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Onpattro.
What happens if I overdose?
Since Onpattro is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
