No formal drug interaction studies involving ophthalmic solution or nasal spray to date. 
Does not inhibit in vitro metabolism of substrates of CYP isoenzymes 1A2, 2C9, 2C19, 2D6, 2E1, or 3A4.
Drugs Affecting or Metabolized by Hepatic Enzymes
Interactions with drugs that inhibit hepatic enzymes (e.g., CYP microsomal enzymes) unlikely because olopatadine is eliminated predominantly by renal excretion.
Potential for olopatadine and its metabolites to act as inducers of CYP isoenzymes not evaluated.
Protein-bound Drugs
Interactions with protein-bound drugs (e.g., possible displacement of other protein-bound drugs) unlikely because olopatadine is modestly protein bound.
Specific Drugs
Drug
Interaction
Comments
CNS depressants (e.g., alcohol)
Possible additive CNS depression when used concomitantly with nasal spray
Avoid concomitant use with nasal spray
