Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur.
Call your doctor right away if you have:
fever, chills, flu symptoms;
pale skin, easy bruising or bleeding;
pain, redness, or swelling where etanercept was injected (for longer than 5 days after injection);
signs of lymphoma--fever, night sweats, weight loss, stomach pain or swelling, swollen glands (in your neck, armpits, or groin);
signs of tuberculosis--cough, night sweats, loss of appetite, weight loss, feeling very tired;
new or worsening psoriasis--skin redness or scaly patches, raised bumps filled with pus;
nerve problems--dizziness, numbness or tingling, problems with vision, or weak feeling in your arms or legs;
signs of heart failure--shortness of breath, swelling in your lower legs;
lupus-like syndrome--joint pain or swelling, chest discomfort, feeling short of breath, skin rash on your cheeks or arms (worsens in sunlight); o
liver problems--right-sided upper stomach pain, vomiting, tiredness, loss of appetite, yellowing of your skin or eyes.
Common side effects may include:
pain, swelling, itching, or redness where the medicine was injected; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Etanercept side effects (more detail)
