Taking fluvoxamine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, opioid medication, muscle relaxer, or medicine for anxiety, depression, or seizures.
Many drugs can interact with fluvoxamine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
methadone, mexiletine, St. John's wort, theophylline, tramadol, tryptophan (also called L-tryptophan);
a diuretic or "water pill";
a blood thinner--warfarin, Coumadin, Jantoven;
medicine to treat anxiety, mood disorders, thought disorders, or mental illness--such as clozapine, lithium, antidepressants, or antipsychotics;
migraine headache medicine--sumatriptan, rizatriptan, zolmitriptan, and others; or
a sedative--diazepam, alprazolam, midazolam, triazolam, Valium, Xanax.
This list is not complete and many other drugs can interact with fluvoxamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
 Fluvoxamine drug interactions (more detail)
