Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your current medicines. Many drugs can affect hydrocortisone, especially:
birth control pills or hormone replacement therapy;
heart medication;
insulin or oral diabetes medicine;
medicine to treat an infection;
seizure medication;
a blood thinner such as warfarin (Coumadin, Jantoven); or
aspirin or an NSAID (nonsteroidal anti-inflammatory drug) such as ibuprofen, naproxen, celecoxib, indomethacin, Advil, Aleve, Motrin, and others.
This list is not complete and many other drugs may affect hydrocortisone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Hydrocortisone drug interactions (more detail)
