Get emergency medical help if you have signs of an allergic reaction to Nplate: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe or ongoing diarrhea;
purple or red spots under your skin;
signs of an ear infection (more common in children) - fever, ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child;
signs of a stroke - sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
signs of a blood clot in your leg - swelling, warmth, or redness in an arm or leg.
Common Nplate side effects may include:
bruising;
headache;
dizziness;
joint pain, muscle weakness or tenderness;
pain in your arms, legs, or shoulder;
numbness or tingling in your hands or feet;
trouble sleeping;
stomach pain, indigestion, nausea, vomiting, diarrhea;
cough, wheezing, chest tightness, trouble breathing;
stuffy nose, sneezing, sinus pain; or
pain in your mouth and throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Nplate side effects (more detail)
