Juvisync can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid), or if you use certain other drugs, such as:
colchicine;
fenofibric acid or fenofibrate;
lomitapide;
high doses of niacin (vitamin B3) or nicotinic acid;
certain heart rhythm medicines--amiodarone or dronedarone; or
heart or blood pressure medication--amlodipine, diltiazem, ranolazine, or verapamil.
This list is not complete and many other drugs can interact with simvastatin and sitagliptin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
 Juvisync drug interactions (more detail)
