You should not use Yosprala if you take medicine that contains rilpivirine, or if you've ever had an asthma attack or severe allergic reaction after taking aspirin or another NSAID (nonsteroidal anti-inflammatory drug).
Aspirin can make you bleed more easily. Call your doctor if you have any unusual bleeding or bruising, or if you cough up blood or have bloody or tarry stools.
Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.
Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.
Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.
You may be more likely to have a broken bone while taking Yosprala long term or more than once per day.
Do not stop using Yosprala suddenly, even if you feel fine.
Before taking this medicine
You should not use Yosprala if you are allergic to aspirin or omeprazole, or if:
you are also allergic to medicines like esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;
you take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey);
you have had an asthma attack or severe allergic reaction (sneezing, runny or stuffy nose, wheezing, chest pain, shortness of breath) after taking aspirin or another NSAID; or
if you had breathing problems, kidney problems, or a severe allergic reaction after taking this medicine in the past.
Yosprala should not be used to treat a sudden onset of heart attack or stroke symptoms (chest pain, sudden numbness or weakness, slurred speech).
Yosprala is not approved for use by anyone younger than 18 years old. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.
Tell your doctor if you have ever had:
a bleeding disorder or vitamin K deficiency;
low levels of magnesium in your blood;
a habit of drinking more than 3 alcoholic beverages per day;
liver or kidney disease;
lupus; or
if you are of Asian descent.
You may be more likely to have a broken bone in your hip, wrist, or spine while taking Yosprala long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.
Yosprala may temporarily affect your ability to get pregnant. Talk with your doctor if this concerns you.
You should not breastfeed while using Yosprala.
How should I take Yosprala?
Take Yosprala exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the lowest dose that is effective in treating your condition.
Take Yosprala with a full glass of water. The usual dose is once daily, 1 hour before a meal.
Swallow the tablet whole and do not crush, chew, or break a tablet.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Yosprala.
Omeprazole may affect a drug-screening urine test and you could have false results. Tell the laboratory staff that you use Yosprala.
Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may increase your risk of heart attack or stroke. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
