Retevmo may cause serious side effects, including:
Liver problems. Liver problems (increased liver enzymes) are common with Retevmo and may sometimes be serious. Your healthcare provider will do blood tests before and during treatment to check for liver problems. Tell your healthcare provider right away if you get any of the following symptoms of liver problems during treatment:
yellowing of your skin or the white part of your eyes (jaundice)
dark “tea-colored” urine
sleepiness
bleeding or bruising
loss of appetite
nausea or vomiting
pain on the upper right side of your stomach area
Your healthcare provider may temporarily stop treatment, lower your dose, or permanently stop treatment if you develop liver problems with Retevmo.
High blood pressure (hypertension). High blood pressure is common with Retevmo and may sometimes be serious. You should check your blood pressure regularly during treatment. Tell your healthcare provider if you get any of the following symptoms:
confusion
headaches
shortness of breath
dizziness
chest pain
Heart rhythm changes (QT prolongation) can occur and may be serious. Retevmo may cause very slow, very fast or irregular heartbeats. Tell your healthcare provider right away if you get any of the following symptoms:
loss of consciousness
fainting
dizziness
a change in the way your heart beats (heart palpitations)
Bleeding problems. Retevmo can cause bleeding which can be serious and may lead to death. Tell your healthcare provider if you have any signs of bleeding during treatment, including:
vomiting blood or if your vomit looks like coffee-grounds
pink or brown urine
red or black (looks like tar) stools
coughing up blood or blood clots
unusual bleeding or bruising of your skin
menstrual bleeding that is heavier than normal
unusual vaginal bleeding
nose bleeds that happen often
drowsiness or difficulty being awakened
confusion
headache
change in speech
Allergic reactions. Retevmo can cause a fever, rash, muscle or joint pain, especially in the first month of treatment. Tell your healthcare provider if you get any of these symptoms. Your healthcare provider may temporarily stop treatment or lower your dose.
Risk of wound healing problems. Wounds may not heal properly during treatment with Retevmo. Tell your healthcare provider if you plan to have any surgery before or during treatment with Retevmo.
You should stop taking Retevmo at least 7 days before planned surgery.
Your healthcare provider should tell you when you may start taking Retevmo again after surgery.
The most common side effects include:
increased levels of liver enzymes
increased blood sugar levels
decrease in white blood cell count
decreased protein levels (albumin) in the blood
decreased levels of calcium in the blood
dry mouth
diarrhea
increased creatinine (kidney function test)
high blood pressure
tiredness
swelling of your arms, legs, hands, and feet (peripheral edema)
decrease in platelet count
increased cholesterol levels
rash
decreased levels of salt (sodium) in the blood
constipation
Retevmo may affect fertility in females and males, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.
These are not all the possible side effects.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Retevmo side effects (more detail)
How should I store Retevmo?
Store Retevmo capsules at room temperature between 68˚F to 77˚F (20˚C to 25˚C).
Keep all medicines out of the reach of children and pets.
General information about the safe and effective use of Retevmo.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for more information that is written for health professionals.
What are the ingredients in Retevmo?
Active ingredient: selpercatinib
Inactive ingredients: microcrystalline cellulose, colloidal silicon dioxide
Capsule: gelatin, titanium dioxide and edible ink
