Usual Adult Dose for Rheumatoid Arthritis:
As monotherapy or in combination with nonbiologic disease-modifying antirheumatic drugs:
-Immediate-release: 5 mg orally 2 times a day
-Extended-release: 11 mg orally once a day
Comments:
-Do not initiate this drug if absolute lymphocyte count is less than 500 cells/mm3, absolute neutrophil count (ANC) is less than 1000 cells/mm3, or hemoglobin is less than 9 g/dL.
-Patients treated with the 5 mg immediate-release 2 times a day may be switched to the 11-mg extended-release once a day the day following the last dose of 5 mg.
Use: For moderately to severely active rheumatoid arthritis (RA) in adult patients who have had an inadequate response or intolerance to methotrexate; it may be used as monotherapy or in combination with methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs)
Usual Adult Dose for Psoriatic Arthritis:
In combination with nonbiologic disease-modifying antirheumatic drugs:
-Immediate-release: 5 mg orally 2 times a day
-Extended-release: 11 mg orally once a day
Comments:
-Do not initiate this drug if absolute lymphocyte count is less than 500 cells/mm3, absolute neutrophil count (ANC) is less than 1000 cells/mm3, or hemoglobin is less than 9 g/dL.
-Patients treated with the 5 mg immediate-release 2 times a day may be switched to the 11-mg extended-release once a day the day following the last dose of 5 mg.
Use: For active psoriatic arthritis in adult patients who have had an inadequate response or intolerance to methotrexate or other DMARDs
Usual Adult Dose for Ulcerative Colitis:
-Induction: 10 mg orally 2 times a day for 8 weeks; evaluate patients and transition to maintenance therapy depending on therapeutic response; if needed, continue 10 mg 2 times a day for a maximum of 16 weeks; discontinue 10 mg 2 times a day after 16 weeks if adequate therapeutic response is not achieved
-Maintenance: 5 mg orally 2 times a day; limit use of 10 mg 2 times a day beyond induction for those with loss of response
Comments:
-Do not initiate this drug if absolute lymphocyte count is less than 500 cells/mm3, absolute neutrophil count (ANC) is less than 1000 cells/mm3, or hemoglobin is less than 9 g/dL.
-Patients treated with the 5 mg immediate-release 2 times a day may be switched to the 11-mg extended-release once a day the day following the last dose of 5 mg.
Use: For the treatment of adult patients with moderately to severely active
ulcerative colitis (UC) who have had an inadequate response or who are intolerant to TNF blockers
 Detailed Xeljanz dosage information
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
