Xeljanz (tofacitinib) blocks the activity of certain enzymes in the body that affect immune system function.
Xeljanz is used to treat moderate to severe rheumatoid arthritis or active psoriatic arthritis in adults who have tried methotrexate or other medications without successful treatment of symptoms. Tofacitinib is sometimes given in combination with methotrexate or other arthritis medicines.
Xeljanz is used to treat adults with moderate to severe ulcerative colitis in adults who cannot use certain other medications, or after other treatments have failed.
Xeljanz is also used to treat active polyarticular juvenile arthritis in patients 2 years of age and older.
