Rapamune may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have any change in your mental state, decreased vision, weakness on one side of your body, or problems with speech or walking. These symptoms may start gradually and get worse quickly.
Get emergency medical help if you have signs of an allergic reaction to Rapamune: hives, rash, or peeling skin; wheezing, difficulty breathing, chest pain or tightness; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
redness, oozing, or slow healing of a skin wound;
a new skin lesion, or a mole that has changed in size or color;
unusual bleeding or bruising;
sudden chest pain or discomfort, cough, feeling short of breath;
tenderness around the transplanted kidney;
signs of infection - fever, chills, painful mouth sores, skin sores, cold or flu symptoms, pain or burning when you urinate; or
low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
Common Rapamune side effects may include:
fever, cold symptoms such as stuffy nose, sneezing, sore throat;
mouth sores;
nausea, stomach pain, diarrhea;
headache, muscle aches;
chest pain;
dizziness; or
acne.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Rapamune side effects (more detail)
