Oxaliplatin can cause a severe or life-threatening allergic reaction. Some people receiving a oxaliplatin injection have had a reaction to the infusion within minutes after the medicine is injected into the vein. Tell your caregiver right away if you feel dizzy, short of breath, confused, sweaty, itchy, or have diarrhea, chest pain, warmth or redness in your face, or feel like you might pass out.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
increased sensitivity to cold temperatures and cold objects;
numbness, tingling, or burning pain that interferes with daily activities;
severe or ongoing diarrhea or vomiting;
confusion, change in mental status, vision problems, seizure (convulsions);
pain or burning when you urinate;
sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;
pain, redness, swelling, or skin changes where the injection was given;
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
heart problems--headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
muscle problems--unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine;
nerve problems--jaw or chest tightness, eye pain, strange feeling in your tongue, problems with speech or swallowing; or
low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
Common side effects may include:
nausea, vomiting, diarrhea;
numbness, tingling, burning pain;
low blood cell counts;
abnormal liver function tests;
mouth sores; or
feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Oxaliplatin side effects (more detail)
