You should not take Ranexa if you have cirrhosis of the liver.
Serious drug interactions can occur when certain medicines are used together with ranolazine. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Ranexa is not for use during an acute (emergency) attack of chest pain. Continue using any other medicines prescribed by your doctor (such as nitroglycerin) to treat acute chest pain.
Before you take Ranexa, tell your doctor about all of your medical conditions, especially if you have a personal or family history of Long QT syndrome.
Chronic angina is often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor.
Before taking this medicine
You should not take Ranexa if you are allergic to ranolazine, or if you have cirrhosis of the liver.
Many other drugs can interact with ranolazine and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:
clarithromycin;
nefazodone;
St. John's wort;
antifungal medicine - itraconazole, ketoconazole;
HIV or AIDS medicine - indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir;
tuberculosis medicine - rifabutin, rifampin, rifapentine; or
seizure medicine-carbamazepine, phenobarbital, phenytoin.
To make sure Ranexa is safe for you, tell your doctor if you have:
a heart rhythm disorder;
liver disease;
kidney disease; or
a personal or family history of long QT syndrome.
It is not known whether Ranexa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether ranolazine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Ranexa?
Take Ranexa exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Ranexa may be taken with or without food.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Call your doctor if your symptoms do not improve, or if they get worse while using Ranexa.
Chronic angina is often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
Store Ranexa at room temperature away from moisture and heat.
