You should not use Lovenox if you have active bleeding, or a low level of platelets in your blood after testing positive for a certain antibody while using enoxaparin.
Lovenox can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural), especially if you have a genetic spinal defect, a history of spinal surgery or repeated spinal taps, or if you are using other drugs that can affect blood clotting, including blood thinners or NSAIDs (ibuprofen, Advil, Aleve, and others). This type of blood clot can lead to long-term or permanent paralysis.
Get emergency medical help if you have symptoms of a spinal cord blood clot such as back pain, numbness or muscle weakness in your lower body, or loss of bladder or bowel control.
Before taking this medicine
You should not use Lovenox if you are allergic to enoxaparin, heparin, benzyl alcohol, or pork products, or if you have:
active or uncontrolled bleeding; or
if you had decreased platelets in your blood after testing positive for a certain antibody while using Lovenox within the past 100 days.
Lovenox may cause you to bleed more easily, especially if you have:
a bleeding disorder that is inherited or caused by disease;
hemorrhagic stroke;
an infection of the lining of your heart (also called bacterial endocarditis);
stomach or intestinal bleeding or ulcer; or
recent brain, spine, or eye surgery.
Lovenox can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term or permanent paralysis, and may be more likely to occur if:
you have a spinal cord injury;
you have a spinal catheter in place or if a catheter has been recently removed;
you have a history of spinal surgery or repeated spinal taps;
you have recently had a spinal tap or epidural anesthesia;
you take aspirin or an NSAID (nonsteroidal anti-inflammatory drug) - ibuprofen (Advil, Motrin), naproxen (Aleve), diclofenac, indomethacin, meloxicam, and others; or
you are using a blood thinner (warfarin, Coumadin) or other medicines to treat or prevent blood clots.
Tell your doctor if you have ever had:
a bleeding disorder such as hemophilia;
kidney or liver disease;
uncontrolled high blood pressure;
eye problems caused by diabetes;
a stomach ulcer; or
low blood platelets after receiving heparin.
Tell your doctor if you are pregnant. If you use Lovenox during pregnancy, make sure your doctor knows if you have a mechanical heart valve.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
