Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your current medicines. Many drugs can interact with trazodone, especially:
any other antidepressants;
phenytoin;
St. John's wort;
tramadol;
a diuretic or "water pill";
medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
a blood thinner - warfarin, Coumadin, Jantoven; or
migraine headache medicine - sumatriptan, Imitrex, Maxalt, Treximet, and others.
This list is not complete and many other drugs may affect trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Trazodone drug interactions (more detail)
