Indomethacin can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use  indomethacin just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Indomethacin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using indomethacin, especially in older adults.
Before taking this medicine
Indomethacin can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Indomethacin may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using indomethacin, especially in older adults.
You should not use indomethacin if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Tell your doctor if you have ever had:
heart disease, high blood pressure;
a heart attack, stroke, or blood clot;
fluid retention;
bleeding problems;
stomach ulcers or bleeding;
asthma;
liver or kidney disease; or
if you smoke.
If you are pregnant, you should not take indomethacin unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
This medicine may temporarily affect fertility (ability to have children) in women.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Indomethacin is not approved for use by anyone younger than 14 years old.
