Sulindac can increase your risk of fatal heart attack or stroke. Do not use  sulindac just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Sulindac may also cause stomach or intestinal bleeding, which can be fatal.
Before taking this medicine
Sulindac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Sulindac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using sulindac, especially in older adults.
You should not use sulindac if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Tell your doctor if you have ever had:
heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
a heart attack, stroke, or blood clot;
stomach ulcers or bleeding;
kidney disease kidney stones;
liver disease;
a pancreas disorder;
asthma;
fluid retention; or
if you take aspirin to prevent heart attack or stroke.
If you are pregnant, you should not take sulindac unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
You should not breastfeed while using this medicine.
Sulindac is not approved for use by anyone younger than 18 years old.
