Get emergency medical help if you have signs of an allergic reaction to Cabometyx: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Call your doctor at once if you have:
severe headache, blurred vision, pounding in your neck or ears;
vomiting, diarrhea, or constipation that are severe and ongoing;
swelling in your hands, arms, legs, or feet;
easy bruising or bleeding (nosebleeds, bleeding gums, heavy menstrual bleeding, or any bleeding that will not stop);
bloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds;
jaundice (yellowing of the skin or eyes);
pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;
confusion, thinking problems, weakness, vision changes, seizure;
a light-headed feeling, like you might pass out;
jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work;
low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough, trouble breathing;
adrenal gland problems - nausea, vomiting, extreme tiredness, dizziness, weakness, fainting; or
signs of a stroke or blood clot - sudden numbness or weakness on one side of your body, problems with vision or balance, trouble speaking or understanding what is said to you, chest pain, trouble breathing, swelling or pain in an arm or leg.
Your future doses of cabozantinib may be delayed or permanently discontinued if you have certain side effects.
Common Cabometyx side effects may include:
stomach pain, nausea, vomiting, loss of appetite, diarrhea, constipation;
pain, redness, swelling, or sores in your mouth or throat;
trouble speaking, changes in taste;
cold symptoms such as stuffy nose, sneezing, sore throat, cough;
rash;
pain in your muscles, bones, and joints;
abnormal liver function tests or other blood tests;
feeling tired;
weight loss; or
hair color turning lighter.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Cabometyx side effects (more detail)
