Edoxaban blocks the activity of certain clotting substances in the blood.
Edoxaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation.  edoxaban is used when the atrial fibrillation is not caused by a heart valve problem.
Edoxaban is also used to treat a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can sometimes occur after a person has been treated with an injectable blood thinner for 5 to 10 days.
Edoxaban may also be used for purposes not listed in this medication guide.
