Ask your doctor before using indomethacin if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Ask a doctor or pharmacist before using indomethacin with any other medications, especially:
cyclosporine;
lithium;
methotrexate;
probenecid;
heart or blood pressure medication, including a diuretic or "water pill";
a blood thinner--warfarin, Coumadin, Jantoven; or
other NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, meloxicam, and others.
This list is not complete. Other drugs may affect indomethacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Indomethacin drug interactions (more detail)
