Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
wheezing, choking, or other breathing problems after using  fluticasone and salmeterol;
fever, chills, cough with mucus, feeling short of breath;
chest pain, fast or irregular heartbeats, severe headache, pounding in your neck or ears;
tremors, nervousness;
blurred vision, tunnel vision, eye pain, or seeing halos around lights;
signs of thrush (a fungal infection)--sores or white patches in your mouth or throat, trouble swallowing;
high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
signs of a hormonal disorder--worsening tiredness or weakness, feeling light-headed, nausea, vomiting.
Fluticasone can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.
Common side effects may include:
headache, muscle pain, bone pain, back pain;
nausea, vomiting;
thrush, throat irritation;
ongoing cough, hoarseness or deepened voice;
cold symptoms such as stuffy nose, sneezing, sore throat; or
ear infection (in a child)--fever, ear pain or full feeling, trouble hearing, drainage from the ear, fussiness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Fluticasone/salmeterol side effects (more detail)
