Some medicines can make levofloxacin much less effective when taken at the same time. If you take any of the following medicines, take your levofloxacin dose 2 hours before or 2 hours after you take the other medicine.
antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids), or the ulcer medicine sucralfate (Carafate);
didanosine (Videx) powder or chewable tablets; or
vitamin or mineral supplements that contain aluminum, iron, magnesium, or zinc.
Tell your doctor about all your other medicines, especially:
theophylline;
a diuretic or "water pill";
heart rhythm medication;
insulin or oral diabetes medicine (check your blood sugar regularly);
medicine to treat depression or mental illness;
steroid medicine (such as prednisone);
a blood thinner--warfarin, Coumadin, Jantoven; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect levofloxacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Levofloxacin drug interactions (more detail)
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