You may need more frequent check- ups or medical tests if you also use medicine to treat depression, diabetes, seizures, or HIV.
Tell your doctor about all your current medicines. Many drugs can affect sulfamethoxazole and trimethoprim, especially:
amantadine, digoxin, cyclosporine, indomethacin, leucovorin, methotrexate, procainamide, pyrimethamine;
an "ACE inhibitor" heart or blood presure medication (benazepril, enalapril, lisinopril, quinapril, ramipril, and others); or
a diuretic or "water pill" (chlorthalidone, hydrochlorothiazide, and others).
This list is not complete and many other drugs may interact with sulfamethoxazole and trimethoprim. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Bactrim drug interactions (more detail)
