You should not use Xadago if you have severe liver disease.
TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE. Some medicines can cause unwanted or dangerous effects (including death) when used within 14 days of when you take Xadago.
Before taking this medicine
You should not use Xadago if you are allergic to safinamide, or if you have:
severe liver disease.
Some medicines can cause unwanted or dangerous effects (including death) when used with Xadago. You should not use any of the following medicines within 14 days before or 14 days after you take Xadago:
amphetamines (Adderall, Dexedrine, and others);
cough medicine that contains dextromethorphan;
cyclobenzaprine;
methylphenidate (Concerta, Ritalin, Daytrana, and others);
St. John's wort;
another MAO inhibitor - isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others;
certain antidepressants such as amitriptyline (Elavil), desipramine (Norpramin), desvenlafaxine (Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), maprotiline (Ludiomil) , milnacipran (Savella), trimipramine (Surmontil), venlafaxine (Effexor), vilazodone (Viibryd), and many others; or
opioid (narcotic) medicine such as meperidine (Demerol), methadone, propoxyphene (Darvon), tramadol (Ultram, Ultracet), and others.
To make sure Xadago is safe for you, tell your doctor if you have ever had:
liver disease;
high or low blood pressure;
bipolar disorder, schizophrenia, or psychosis;
unusual urges or impulses;
abnormal muscle movements;
problems with retina of your eye; or
narcolepsy or other sleep disorder (or if you take medicine to help you sleep).
It is not known whether Xadago will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether safinamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Xadago?
Take Xadago exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Safinamide must be given in combination with levodopa and carbidopa and it should not be used alone.
Xadago is usually taken once per day at the same time each day.
You may take this medicine with or without food.
Your blood pressure will need to be checked often.
Store at room temperature away from moisture and heat.
