Get emergency medical help if you have signs of an allergic reaction to progesterone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
unusual vaginal bleeding;
pain or burning when you urinate;
a breast lump;
sudden vision problems, severe headache or pain behind your eyes;
symptoms of depression (sleep problems, weakness, mood changes);
severe dizziness or drowsiness, spinning sensation, confusion, shortness of breath;
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with speech or balance;
signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs.
Common progesterone side effects may include:
drowsiness, dizziness;
breast pain;
mood changes;
headache;
constipation, diarrhea, heartburn;
bloating, swelling in your hands or feet;
joint pain;
hot flashes; or
vaginal discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Progesterone side effects (more detail)
