Usual Adult Dose of Kymriah for Acute Lymphoblastic Leukemia:
Up to Age 25 Years:
-Body Weight 50 kg or less: 0.2 to 5 x 10(6) chimeric antigen receptor (CAR)-positive viable T cells per kg of body weight.
-Body Weight Above 50 kg: 0.1 to 2.5 x 10(8) CAR-positive viable T cells
Duration of Therapy: Infuse this drug 2 to 14 days after completion of lymphodepleting chemotherapy.
Comments:
-Base the dosage on the patient's weight at the time of leukapheresis.
-Administer this drug via IV infusion within 30 minutes of thawing at 10 to 20 mL per minute (adjusted as appropriate for smaller children and smaller volumes); the infusion bag volume ranges from 10 to 50 mL.
-Pre-medicate patients with acetaminophen and diphenhydramine or another H1-antihistamine approximately 30 to 60 minutes prior to infusion of this drug; avoid using corticosteroids at any time except in the case of a life-threatening emergency.
Use: Treatment of patients up to age 25 with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.
Usual Pediatric Dose for Acute Lymphoblastic Leukemia:
-Body Weight 50 kg or less: 0.2 to 5 x 10(6) chimeric antigen receptor (CAR)-positive viable T cells per kg of body weight.
-Body Weight Above 50 kg: 0.1 to 2.5 x 10(8) CAR-positive viable T cells
Duration of Therapy: Infuse this drug 2 to 14 days after completion of lymphodepleting chemotherapy.
Comments:
-Base the dosage on the patient's weight at the time of leukapheresis.
-Administer this drug via IV infusion within 30 minutes of thawing at 10 to 20 mL per minute, adjusted as appropriate for smaller children and smaller volumes; the infusion bag volume ranges from 10 to 50 mL.
-Pre-medicate patients with acetaminophen and diphenhydramine or another H1-antihistamine approximately 30 to 60 minutes prior to infusion of this drug; avoid using corticosteroids at any time except in the case of a life-threatening emergency.
Use: Treatment of patients up to age 25 with B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse.
 Detailed Kymriah dosage information
What happens if I miss a dose?
Call your doctor for instructions if you miss any of your chemotherapy treatment, or if you miss a dose of your medications to prevent side effects of Kymriah.
What happens if I overdose?
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
