Usual Adult Dose for Parkinson's Disease:
Optimum dosage is determined by careful individual titration: All doses expressed as CARBIDOPA-LEVODOPA
Rytary extended-release capsules:
-Initial dose (levodopa-naive): 23.75 mg-95 mg orally 3 times a day for 3 days; on the fourth day, may increase to 36.25 mg-145 mg 3 times a day
-Dosing interval may be increased up to a maximum of 5 times a day, if tolerated
-Maximum daily dose: 612.5 mg-2450 mg
Conversion from IMMEDIATE-RELEASE carbidopa-levodopa to Rytary: These recommended starting doses should be divided and given three times a day:
-For patients receiving levodopa 400 to 549 mg/day: total daily dose of levodopa in Rytary - 855 mg/day
-For patients receiving levodopa 550 to 749 mg/day: total daily dose of levodopa in Rytary - 1140 mg/day
-For patients receiving levodopa 750 to 949 mg/day: total daily dose of levodopa in Rytary - 1305 mg/day
-For patients receiving levodopa 950 to 1249 mg/day: total daily dose of levodopa in Rytary - 1755 mg/day
-For patients receiving levodopa equal or greater than 1250 mg/day: Rytary levodopa dose should be 2205 or 2340 mg/day
Comments:
-Peripheral dopa decarboxylase is saturated by carbidopa at approximately 70 to 100 mg/day; patient's receiving less than this amount of carbidopa are more likely to experience nausea and vomiting; experience with carbidopa doses greater than 200 mg/day is limited.
-Rytary products are not interchangeable with other carbidopa-levodopa products; for patients receiving carbidopa-levodopa plus catechol-O-methyl transferase (COMT) inhibitors, the initial recommended total daily dose of levodopa may need to be increased.
Use: For the treatment of the symptoms of idiopathic Parkinson's disease, postencephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication.
 Detailed Rytary dosage information
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
