Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
Methotrexate is used to treat leukemia and certain types of cancer of the breast, skin, head and neck, lung, or uterus.
Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis in adults. It is also used to treat active polyarticular-course juvenile rheumatoid arthritis in children.
Methotrexate is sometimes given when other medicines have not been effective.
