Get emergency medical help if you have any signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
new or unusual pain in your thigh, hip, or groin;
severe pain in your joints, muscles, or bones;
skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or
low levels of calcium in your blood (hypocalcemia) - numbness or tingly feeling around your mouth or in your fingers or toes, muscle tightness or contraction, overactive reflexes.
Serious infections may occur during treatment with Prolia. Call your doctor right away if you have signs of infection such as:
fever, chills, night sweats;
swelling, pain, tenderness, warmth, or redness anywhere on your body;
pain or burning when you urinate;
increased or urgent need to urinate;
severe stomach pain; or
cough, feeling short of breath.
Common Prolia side effects may include:
bladder infection (painful or difficult urination);
back pain, muscle pain; or
pain in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Prolia side effects (more detail)
