Using  Lomotil with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, cold or allergy medicine, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your other medicines. Some may affect Lomotil, especially:
medicine to treat Parkinson's disease;
medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;
bladder or urinary medicines;
a bronchodilator; or
an MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
This list is not complete. Other drugs may affect Lomotil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Lomotil drug interactions (more detail)
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