Get emergency medical help if you have signs of an allergic reaction to Lupron Depot (hives, sweating, fast heartbeats, dizziness, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
problems with your pituitary gland - sudden severe headache, vomiting, problems with your eyes or vision, changes in mood or behavior;
bone pain, loss of movement in any part of your body;
swelling, rapid weight gain;
a seizure;
unusual changes in mood or behavior (crying spells, anger, feeling irritable);
sudden chest pain or discomfort, wheezing, dry cough or hack;
painful or difficult urination; or
high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor.
Rare but serious side effects may occur. Call your doctor if you have:
pain or unusual sensations in your back, numbness, weakness, or tingly feeling in your legs or feet;
muscle weakness or loss of use, loss of bowel or bladder control;
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech.
Common Lupron Depot side effects may include:
pituitary gland problems;
cold symptoms such as stuffy nose, sneezing, sore throat, cough with or without mucus;
fever, tiredness, not feeling well;
stomach pain, nausea, vomiting, constipation;
wheezing, chest tightness, trouble breathing;
hot flashes, sweating;
dizziness, mood changes;
headache, general pain;
vaginal swelling, itching, or discharge;
weight changes;
decreased testicle size;
decreased interest in sex; or
redness, pain, swelling, or oozing where the shot was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Lupron Depot side effects (more detail)
