If you also take cholestyramine or colestipol, take your hydrochlorothiazide and valsartan dose 4 hours before or 4 hours after you take the other medicine.
Tell your doctor about all your current medicines. Many drugs can affect hydrochlorothiazide and valsartan, especially:
cyclosporine, digoxin, digitalis, lithium, or ritonavir;
all your heart or blood pressure medicines;
insulin or oral diabetes medicine;
a diuretic or "water pill";
opioid pain medicine;
a sleeping pill;
a muscle relaxer;
an antibiotic--rifabutin, rifampin, rifamycin, rifapentine;
cancer medicine--cyclophosphamide, methotrexate; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete and many other drugs may affect hydrochlorothiazide and valsartan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Hydrochlorothiazide/valsartan drug interactions (more detail)
