General
Although manufacturer makes no specific recommendations regarding test doses, test doses of iron sucrose (20–25 or 50 mg) have been administered in some patients.    (See Sensitivity Reactions under Cautions.)
Ensure immediate availability of personnel trained to provide emergency treatment and appropriate agents for the treatment of a severe allergic or anaphylactic reaction when administering iron sucrose injection.
Administration
IV Administration
For solution and drug compatibility information, see Compatibility under Stability.
Administer (diluted) by IV infusion or (undiluted) by slow IV injection.
Do not mix with other drugs or add to parenteral nutrition solutions for IV infusion.
Dilution
For IV infusion, dilute in 0.9% sodium chloride injection; specific recommendations for dilution vary depending on the intended patient population (see Dosage). Do not dilute to concentrations <1 mg/mL.
Dosage
Dosage expressed in terms of mg of elemental iron. Iron sucrose injection contains the equivalent of 20 mg of elemental iron per mL.
Pediatric Patients
Iron Maintenance Treatment in Patients with Hemodialysis-dependent CKD
IV
Children ≥2 years of age: 0.5 mg/kg (not to exceed 100 mg per dose) every 2 weeks for 12 weeks; may administer undiluted by slow IV injection over 5 minutes or diluted in 25 mL of 0.9% sodium chloride injection over 5–60 minutes.
Repeat treatment if necessary.
Iron Maintenance Treatment in Patients with Non-dialysis-dependent CKD Receiving ESAs
IV
Children ≥2 years of age: 0.5 mg/kg (not to exceed 100 mg per dose) every 4 weeks for 12 weeks; may administer undiluted by slow IV injection over 5 minutes or diluted in 25 mL of 0.9% sodium chloride injection over 5–60 minutes.
Repeat treatment if necessary.
Iron Maintenance Treatment in Patients with Peritoneal Dialysis-dependent CKD Receiving ESAs
IV
Children ≥2 years of age: 0.5 mg/kg (not to exceed 100 mg per dose) every 4 weeks for 12 weeks; may administer undiluted by slow IV injection over 5 minutes or diluted in 25 mL of 0.9% sodium chloride injection over 5–60 minutes.
Repeat treatment if necessary.
Adults
Patients with Hemodialysis-dependent CKD
IV
100 mg by slow IV injection (over 2–5 minutes) or by IV infusion (diluted in a maximum of 100 mL of 0.9% sodium chloride injection and administered over at least 15 minutes) during each consecutive hemodialysis session. Administer early during dialysis procedure.
A cumulative dose of 1 g of iron sucrose usually is required.
Repeat treatment if necessary.
Patients with Non-dialysis-dependent CKD
IV
200 mg by slow IV injection (over 2–5 minutes) or IV infusion (diluted in a maximum of 100 mL of 0.9% sodium chloride injection and administered over 15 minutes) for a total of 5 doses; administer the doses on 5 different occasions over a 14-day period.
Also has been administered in a dosage of 500 mg by IV infusion (diluted in a maximum of 250 mL of 0.9% sodium chloride injection) on days 1 and 14; administer each dose over 3.5–4 hours.
Repeat treatment if necessary.
Patients with Peritoneal Dialysis-dependent CKD
IV
Administer a series of 3 doses, each dose spaced 14 days apart, over 28 days. For the first 2 doses, administer 300 mg by IV infusion (diluted in a maximum of 250 mL of 0.9% sodium chloride injection and administered over 1.5 hours); follow with a dose of 400 mg (diluted in a maximum of 250 mL of 0.9% sodium chloride injection and administered over 2.5 hours).
Repeat treatment if necessary.
Prescribing Limits
Pediatric Patients
IV
Do not exceed 100 mg per dose.
Special Populations
Geriatric Patients
Select dosage with caution because of age-related decreases in hepatic, renal, and/or cardiac function and of concomitant disease and/or other drug therapies.
 Detailed Iron sucrose dosage information
