Taking febuxostat may increase your risk of serious or fatal heart problems. Seek medical attention if you have chest pain, trouble breathing, fast heartbeats, sudden severe headache, numbness or weakness on one side of your body, or problems with vision or speech.
You should not use febuxostat if you also use azathioprine or mercaptopurine.
Before taking this medicine
You should not use febuxostat if you are allergic to it, or if you also use:
azathioprine; or
mercaptopurine.
Taking febuxostat may increase your risk of serious or fatal heart problems. Talk with your doctor about the risks and benefits of  febuxostat.
Tell your doctor if you have ever had:
heart problems;
a heart attack or stroke;
liver or kidney disease;
cancer;
Lesch-Nyhan syndrome; or
an organ transplant (kidney, liver, lung, heart).
Tell your doctor if you are pregnant or breastfeeding.
How should I take febuxostat?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take febuxostat with or without food. Febuxostat may be taken with an antacid if needed.
You may have an increase in gout symptoms (flares) when you first start taking febuxostat. Your doctor may prescribe other medications for you to use during the first 6 months of treatment with febuxostat.
You should not stop using febuxostat suddenly. Stopping suddenly may make your condition worse.
For best results, keep using your medications as directed. Call your doctor if your symptoms do not improve after 6 months, or if they get worse.
You will need frequent blood tests to check your liver function.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
