Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. This medicine can also increase your risk of serious bleeding.
Call your doctor if you have: severe stomach pain, choking or gagging when you eat or drink, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood.
Before taking this medicine
To make sure Cabometyx is safe for you, tell your doctor if you have:
an open wound on your skin (or a wound that is still healing);
bleeding problems (such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds);
high blood pressure;
liver disease; or
a pre-existing dental problem.
You may need to have a negative pregnancy test before starting this treatment.
Cabozantinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using Cabometyx and for at least 4 months after your last dose. Tell your doctor if you think you might be pregnant.
Cabozantinib may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Cabometyx can harm an unborn baby.
You should not breastfeed while using Cabometyx, and for at least 4 months after your last dose.
How should I take Cabometyx?
Take Cabometyx exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Do not use Cabometyx tablets in place of Cometriq (cabozantinib) capsules. Take only the pill form your doctor has prescribed. Avoid medication errors by always checking the medicine you receive at the pharmacy.
Take Cabometyx on an empty stomach, at least 1 hour before or 2 hours after you eat anything.
Do not take Cabometyx with food.
Take this medicine with a full glass of water.
Do not crush, chew, or break a tablet, and do not open a capsule. Swallow the pill whole.
When used with Cabometyx, nivolumab is usually given as an infusion into a vein once every 2 to 4 weeks.
Your blood pressure and liver function may need to be checked often.
If you need surgery or dental work, stop taking Cabometyx at least 3 weeks ahead of time. After a surgery or dental procedure, you may need to wait 2 weeks before you start taking Cabometyx again. Follow your doctor's dosing instructions very carefully.
If you have stopped taking Cabometyx for any reason, talk with your doctor before you start taking it again.
Store at room temperature away from moisture and heat.
