Usual Adult Dose for Atopic Dermatitis:
Initial dose: 600 mg subcutaneously (two 300 mg injections at different sites)
Maintenance dose: 300 mg subcutaneously every other week
Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used but should be reserved for problem areas only (e.g., face, neck, intertriginous, genital areas).
Use: For moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable
Usual Adult Dose for Asthma:
400 mg subcutaneously (two 200 mg injections at different sites) initially, followed by 200 mg subcutaneously every other week
OR
600 mg subcutaneously (two 300 mg injections at different sites) initially, followed by 300 mg subcutaneously every other week
For patients requiring concomitant oral corticosteroids or with comorbid moderate-to-severe atopic dermatitis:
600 mg subcutaneously initially followed by 300 mg subcutaneously every other week.
Use: As add-on maintenance treatment in patients with moderate-to-severe asthma with an eosinophilic phenotype or with oral corticosteroid dependent asthma
Usual Adult Dose for Sinusitis:
300 mg subcutaneously every other week
Use: As an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP)
Usual Pediatric Dose for Atopic Dermatitis:
6 years or older:
15 to less than 30 kg:
-Initial dose: 600 mg subcutaneously (two 300 mg injections at different sites)
-Maintenance dose: 300 mg subcutaneously every 4 weeks
30 to less than 60 kg:
-Initial dose: 400 mg subcutaneously (two 200 mg injections at different sites)
-Maintenance dose: 200 mg subcutaneously every other week
60 kg or greater:
-Initial dose: 600 mg subcutaneously (two 300 mg injections at different sites)
-Maintenance dose: 300 mg subcutaneously every other week
Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used but should be reserved for problem areas only (e.g., face, neck, intertriginous, genital areas).
Use: For patients 6 years and older with moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable
Usual Pediatric Dose for Asthma:
12 years and older:
400 mg subcutaneously (two 200 mg injections at different sites) initially, followed by 200 mg subcutaneously every other week
OR
600 mg subcutaneously (two 300 mg injections at different sites) initially, followed by 300 mg subcutaneously every other week
For patients requiring concomitant oral corticosteroids or with comorbid moderate-to-severe atopic dermatitis:
600 mg subcutaneously initially followed by 300 mg subcutaneously every other week
Use: As add-on maintenance treatment in patients 6 years and older with moderate-to-severe asthma with an eosinophilic phenotype or with oral corticosteroid dependent asthma
 Detailed Dupixent dosage information
What happens if I miss a dose?
If you miss your injection by 7 days or less, use the missed dose as soon as you remember and then go back to your regular injection schedule.
If you are more than 7 days late for the injection:
For the every-other-week injection schedule: Skip the missed dose and use the medicine at your next scheduled injection time.
For the every-4-weeks schedule: Start a new dosing schedule on the day you use the missed injection and use your next injection 4 weeks later.
Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
