Usual Adult Dose of Xultophy for Diabetes Type 2:
Basal Insulin or GLP-1 Receptor Agonist Naive:
Initial dose: 10 units subcutaneously once a day
Currently receiving a Basal Insulin or GLP-1 Receptor Agonist
-Discontinue therapy with basal insulin and/or liraglutide
Initial dose: 16 units subcutaneously once a day
TITRATION: Adjust dose up or down in increments of 2 units every 3 to 4 days based on individual metabolic needs, blood glucose monitoring, and glycemic goal until desired fasting plasma glucose is achieved
Maximum daily dose: 50 units (insulin degludec 50 units; liraglutide 1.8 mg)
Comments:
-Dosing is provided as insulin degludec units; the liraglutide component dose for each unit of insulin degludec is displayed on a dosing table in the package labeling; 10 units of insulin degludec provides 0.36 mg of liraglutide.
-To minimize the risk of hypoglycemia or hyperglycemia, additional titration may be necessary with changes in physical activity, food intake, during acute illness, or with use of concomitant medications.
-This combination drug is not recommended as first-line therapy because of the uncertainty of rodent C-cell tumor finding to humans.
-The combination drug has not been studied in combination with prandial insulin.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
 Detailed Xultophy dosage information
What happens if I miss a dose?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
If you miss your dose for more than 3 days in a row, call your doctor for instructions.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You should not use more than 50 units of this medicine in one day.
