Nexlizet may cause serious side effects, including:
increased levels of uric acid in your blood (hyperuricemia). This can happen within 4 weeks of you starting Nexlizet and continue throughout your treatment. Your healthcare provider may monitor your blood uric acid levels while you are taking Nexlizet. High levels of blood uric acid may lead to gout. Call your healthcare provider if you have the following symptoms of hyperuricemia and gout:
severe foot pain especially in the toe joint
warm joints
swelling
tender joints
joint redness
Gout may happen more in people who have had gout before but also can happen in people who have never had it before.
tendon rupture or injury. Tendon problems can happen in people who take bempedoic acid, one of the medicines in Nexlizet. Tendons are tough cords of tissue that connect muscles to bones. Symptoms of tendon problems may include pain, swelling, tears, and inflammation of tendons including the arm, shoulder, and back of the ankle (Achilles).
Tendon rupture can happen while you are taking Nexlizet. Tendon ruptures can happen within weeks or months of starting Nexlizet.
The risk of getting tendon problems while you take Nexlizet is higher if you:
are over 60 years of age
are taking antibiotics (fluoroquinolones)
have had tendon problems
are taking steroids (corticosteroids)
have renal failure
Stop taking Nexlizet immediately and get medical help right away if you get any of the following signs or symptoms of a tendon rupture:
hear or feel a snap or pop in a tendon area
bruising right after an injury in a tendon area
unable to move the affected area or put weight on the affected area
Stop taking Nexlizet until tendon rupture has been ruled out by your healthcare provider. The most common areas of pain and swelling are the rotator cuff (the shoulder), the biceps tendon (upper arm), and the Achilles tendon at the back of the ankle. This can happen with other tendons.
Talk to your healthcare provider about the risk of tendon rupture with continued use of Nexlizet. You may need a different lipid lowering medicine to treat your cholesterol levels.
The most common side effects include:
symptoms of the common cold, flu, or flu-like symptoms
back pain
bronchitis
anemia
diarrhea
muscle spasms
stomach pain
pain in shoulder, legs, or arms
increased liver enzymes
fatigue
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects. Ask your healthcare provider or pharmacist for more information.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Nexlizet side effects (more detail)
How should I store Nexlizet?
Store Nexlizet in the original package at room temperature between 68ºF to 77ºF (20ºC to 25ºC).
Protect from heat and moisture.
Do not throw away the packet that helps to keep your medicine dry (desiccant).
Nexlizet comes in a bottle with a child-resistant cap.
Keep all medicines out of the reach of children and pets.
General information about the safe and effective use of Nexlizet.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it wasnot prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for healthcare professionals.
What are the ingredients in Nexlizet?
Active Ingredients: bempedoic acid and ezetimibe
Inactive Ingredients: colloidal silicon dioxide, hydroxy propyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone K30, sodium lauryl sulfate, sodium starch glycolate
Tablet coating: FD&C Blue #1/Brilliant Blue FCF Aluminum Lake, FD&C Blue #2/Indigo Carmine Aluminum Lake, glyceryl monocaprylocaprate, partially hydrolyzed polyvinyl alcohol, sodium lauryl sulfate, talc, and titanium dioxide
