Phexxi may cause serious side effects, including:
Bladder infection (cystitis) and acute kidney infection (pyelonephritis). Urinary tract infections are common but can also be serious. You should not use Phexxi if you have a history of urinary tract infections that keep coming back or other problems with your urinary tract. Call your healthcare provider if you have burning with urination or other signs and symptoms of a urinary tract infection such as: burning feeling when passing urine, urine that looks cloudy, pain in the pelvis, or back pain.
Allergic reactions. Avoid using Phexxi if you are a female who can become pregnant and are allergic to lactic acid, citric acid, potassium bitartrate or any of the ingredients in Phexxi; or your sexual partners are allergic to any of the ingredients in Phexxi”. Stop using Phexxi if you have a local vulvovaginal reaction.
The most common side effects include:
vaginal burning
vaginal itching
vaginal yeast infection
discomfort around the vaginal area
bacterial vaginosis
vaginal discharge
discomfort in the genital area
pain while passing urine
These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Phexxi side effects (more detail)
How should I store Phexxi?
Store Phexxi at room temperature between 68°F to 77°F (20°C to 25°C).
Store Phexxi in the original foil pouch.
Keep Phexxi and all medicines out of the reach of children.
General information about the safe and effective use of Phexxi.
Medicines are sometimes used for purposes other than those listed in a Patient Information leaflet. Do not use this product for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms that you have. It may harm them.
You can ask your healthcare provider or pharmacist for information about Phexxi that is written for health professionals.
What are the ingredients in Phexxi?
Active ingredients: lactic acid, citric acid, and potassium bitartrate
Inactive ingredients: glycerin, alginic acid, xanthan gum, sodium hydroxide, benzoic acid, and purified water
INSTRUCTIONS FOR USE
These Instructions for Use contains information on how to use Phexxi vaginal gel.
Make sure that you read, understand, and follow the Instructions for Use before using Phexxi and each time you get a refill. There may be new information.
Important Information You Need to Know Before Using Phexxi
Use 1 dose of Phexxi within 1 hour before you have vaginal sex.
A new Phexxi pre-filled applicator must be used each time you have vaginal sex. If you have vaginal sex more than 1 time within 1 hour, a new Phexxi pre-filled applicator must be used.
Prepare to Use Phexxi
Keep the pre-filled applicator and plunger rod in the foil pouch until you are ready to use Phexxi.
Step 1: Wash Your Hands
Wash your hands with soap and water before opening the foil pouch.
Step 2: Remove the Pre-filled Applicator and Plunger Rod from the Foil Pouch
Remove the pre-filled applicator and plunger rod from the foil pouch.
Important: Do not remove the pink cap until instructed in Step 4.
Step 3: Insert the Plunger Rod
Gently and slowly insert the plunger rod into the pre-filled applicator. Push until you feel the tip of the plunger rod connect to the inside of the pre-filled applicator.
Do not push hard or continue to push after the tip of the plunger rod connects to the inside of the pre-filled applicator. This could cause the gel to go into the pink cap.
Use a new pre-filled applicator if the gel goes into the pink cap.
Step 4: Remove the Pink Cap
After the plunger rod is connected to the pre-filled applicator, remove the pink cap from the pre-filled applicator.
The extra space between the gel and the end of the pre-filled applicator is normal.
The pre-filled applicator is now ready for use.
Step 5: Insert the Phexxi Pre-filled Applicator into the Vagina
Hold the pre-filled applicator at the grooved area closest to the plunger rod.
Gently insert the pre-filled applicator into the vagina as far as it will comfortably go while you continue to hold it by the grooved area firmly.
This can be done sitting with your knees apart, lying on your back with your knees bent, or while standing with your feet apart or knees bent.
Step 6: Insert Phexxi Gel
While the pre-filled applicator is inserted in your vagina, use your index finger to push the plunger rod down until it stops. This is to make sure you
receive the entire dose of Phexxi.
It is normal for a small amount of gel to be left in the applicator. You will still get the right dose.
Step 7: Remove the Used Phexxi Pre-filled Applicator
Gently remove the plunger rod and pre-filled applicator from the vagina and throw away (dispose of) the used pre-filled applicator.
Phexxi should be used within 1 hour before each time you have vaginal sex. Use a new pre-filled applicator if you do not have vaginal sex within 1 hour of inserting Phexxi gel and you still plan to have vaginal sex.
Step 8: Throw Away (Dispose of) the Used Phexxi Pre-filled Applicator
Used Phexxi pre-filled applicators and caps should be disposed of in the trash. The cap may be a potential choking hazard.
Store Phexxi at room temperature between 68°F to 77°F (20°C to 25°C).
Store Phexxi in the original foil pouch.
