What is a TP53 genetic test?A TP53 genetic test looks for a change, known as a mutation, in a gene called TP53 (tumor protein 53). Genes are the basic units of heredity passed down from your mother and father.TP53 is a gene that helps stop the growth of tumors. It's known as a tumor suppressor. A tumor suppressor gene works like the brakes on a car. It puts the "brakes" on cells, so they don't divide too quickly. If you have a TP53 mutation, the gene may not be able to control the growth of your cells. Uncontrolled cell growth can lead to cancer.A TP53 mutation can be inherited from your parents, or acquired later in life from the environment or from a mistake that happens in your body during cell division.An inherited TP53 mutation is known as Li-Fraumeni syndrome.Li-Fraumeni syndrome is a rare genetic condition that can increase your risk of certain types of cancers.These cancers include breast cancer, bone cancer, leukemia, and soft tissue cancers, also called sarcomas.Acquired (also known as somatic) TP53 mutations are much more common. These mutations have been found in about half of all cases of cancer, and in many different types of cancer.Other names: TP53 mutation analysis, TP53 full gene analysis, TP53 somatic mutation
