Kaletra can cause a serious heart problem, especially if you use certain other medicines at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using.
Call your doctor at once if you have a headache with chest pain, fast or pounding heartbeats, and severe dizziness.
Before taking this medicine
You should not use Kaletra if you have ever had a severe allergic reaction to lopinavir or ritonavir.
Some medicines can cause unwanted or dangerous effects when used with Kaletra. Your doctor may need to change your treatment plan if you use any of the following drugs:
alfuzosin;
apalutamide;
cisapride;
colchicine;
dronedarone;
elbasvir/grazoprevir;
lomitapide;
lurasidone, pimozide;
ranolazine;
rifampin;
lovastatin, simvastatin;
triazolam, or oral midazolam;
sildenafil (Revatio for pulmonary arterial hypertension);
St. John's wort; or
an ergot medicine (ergotamine, dihydroergotamine, methylergonovine).
To make sure Kaletra is safe for you, tell your doctor if you have ever had:
liver disease (especially hepatitis B or C);
heart disease, heart rhythm disorder, or a family history of long QT syndrome;
pancreas problems;
diabetes;
low levels of potassium in your blood; or
a bleeding disorder such as hemophilia.
It is not known whether Kaletra will harm an unborn baby. But HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Kaletra on the baby.
Kaletra can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using Kaletra, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.
Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Kaletra is not approved for use by anyone younger than 14 days old. Premature infants should not receive the medication until it has been 14 days after their original due date.
