Taking Zanaflex with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your other medicines, especially:
acyclovir;
ticlopidine;
zileuton;
birth control pills;
an antibiotic, including ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, or others;
blood pressure medicine such as clonidine, guanfacine, methyldopa;
heart rhythm medicine including amiodarone, mexiletine, propafenone, verapamil; or
stomach acid medicine such as cimetidine, famotidine.
This list is not complete. Other drugs may interact with tizanidine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
 Zanaflex drug interactions (more detail)
