Get emergency medical help if you have signs of an allergic reaction to Bavencio: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel light-headed, itchy, feverish, chilled, or have stomach or back pain, trouble breathing, or flushing (warmth, redness, or tingly feeling).
Avelumab works by causing your immune system to attack tumor cells. Avelumab may cause your immune system to attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, or adrenal glands.
Call your doctor at once if you have:
sudden chest pain or discomfort;
severe stomach pain, diarrhea, bloody or tarry stools;
blistering or peeling skin rash;
pounding heartbeats or fluttering in your chest;
flu-like symptoms;
pain or burning when you urinate;
joint pain, weakness;
vision changes;
liver problems - loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
heart problems - chest pain or pressure, pain spreading to your jaw or shoulder, sweating;
kidney problems - little or no urination, red or pink urine, swelling in your feet or ankles; or
signs of a hormonal disorder - feeling light-headed or very tired, rapid heartbeats, mood or behavior changes, deepened voice, increased hunger or thirst, increased urination, constipation, vomiting, hair loss, sweating, feeling cold, weight gain, or weight loss.
Common Bavencio side effects may include:
hoarse voice;
cough, shortness of breath;
trouble speaking;
pain, blisters, bleeding, or severe rash on the palms of your hands or the soles of your feet;
sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;
severe headache, blurred vision, pounding in your neck or ears;
painful urination;
stomach pain, nausea, diarrhea, loss of appetite;
feeling tired;
chills, fever;
muscle pain, back pain, bone pain;
rash;
swelling in your hands or feet;
redness or swelling where the injection was given;
liver problems; or
symptoms of underactive thyroid - tiredness, depressed mood, dry skin, thinning hair, decreased sweating, weight gain, puffiness in your face, feeling more sensitive to cold temperatures.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Bavencio side effects (more detail)
