Usual Adult Dose for Diabetes Type 2:
To improve glycemic control:Initial dose: 5 mg orally once a day-May increase to 10 mg orally once a day for additional glycemic control if lower dose has been toleratedMaximum dose: 10 mg/dayTo reduce the risk of hospitalization for heart failure: 10 mg orally once a day Comments:-Correct volume depletion prior to initiating therapy.  -Ensure adequate renal function (eGFR greater than 45 mL/min/1.73 m2) as glycemic efficacy is dependent on adequate renal function.  -If used in combination with insulin or an insulin secretagogue, a lower dose of insulin or the insulin secretagogue should be considered to reduce the risk of hypoglycemia.  Uses: -As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.-To reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus and established cardiovascular disease (CVD) or multiple cardiovascular (CV) risk factors.
Usual Adult Dose for Heart Failure with Reduced Ejection Fraction:
10 mg orally once a dayComments: -Correct volume depletion prior to initiating therapy.  -This drug is not recommended for patients with type 1 diabetes mellitus.  Use: To reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure (NYHA class II-IV) with reduced ejection fraction.
Usual Adult Dose for Chronic Kidney Disease:
10 mg orally once a dayComments: -Correct volume depletion prior to initiating therapy.  -This drug is not recommended in patients with polycystic kidney disease or patients requiring, or with a recent history of immunosuppressive therapy for kidney disease, as it is not expected to be effective.-This drug is not recommended for patients with type 1 diabetes mellitus.  Use: To reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, andhospitalization for heart failure in adults with chronic kidney disease at risk of progression.
 Detailed Dapagliflozin dosage information
