Using Remeron with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your current medicines. Many drugs can interact with mirtazapine, especially:
cimetidine;
diazepam;
St. John's wort;
tramadol;
tryptophan (sometimes called L-tryptophan);
an antibiotic - clarithromycin, rifampin, rifampicin, telithromycin;
antifungal medicine - itraconazole, ketoconazole;
antiviral medicine to treat HIV/AIDS - indinavir, nelfinavir, ritonavir, saquinavir;
medicine to treat mood disorders, thought disorders, or mental illness - such as lithium, other antidepressants, or antipsychotics;
migraine headache medicine - sumatriptan, rizatriptan, Imitrex, Maxzalt, and others; or
seizure medicine - carbamazepine, phenytoin.
This list is not complete and many Other drugs may interact with mirtazapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Remeron drug interactions (more detail)
