Get emergency medical help if you have signs of an allergic reaction to oxycodone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine, including oxycodone, can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
a slow heart rate or weak pulse;
cold, clammy skin;
a light-headed feeling, like you might pass out;
confusion, unusual thoughts or behavior;
seizure (convulsions);
low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
high levels of serotonin in the body - agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.
Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.
Long-term use of opioid medication, such as oxycodone, may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common oxycodone side effects may include:
drowsiness, dizziness, tiredness;
headache;
constipation, stomach pain, nausea, vomiting; or
itching, red eyes, or flushing.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Oxycodone side effects (more detail)
