Tibsovo can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 1 days to 3 months after you start taking ivosidenib.
Seek medical help right away if you have symptoms of differentiation syndrome: fever, dizziness, cough, trouble breathing, swelling, rapid weight gain, rash, or decreased urination.
Before taking this medicine
You should not use Tibsovo if you are allergic to ivosidenib.
To make sure Tibsovo is safe for you, tell your doctor if you have ever had:
heart disease;
long QT syndrome (in you or a family member);
nerve problems; or
an electrolyte imbalance (such as low levels of potassium, sodium, or magnesium in your blood).
Ivosidenib may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
Tibsovo can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using Tibsovo, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.
This medicine may affect fertility (ability to have children) in both men and women. However, women should still use birth control to prevent pregnancy because ivosidenib can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 month after your last dose.
How should I take Tibsovo?
Take Tibsovo exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Swallow the tablet whole and do not crush, chew, or break it.
Take the medicine at the same time each day, with or without food.
Drink plenty of liquids while you are taking Tibsovo.
Do not take Tibsovo with foods that are high in fat, such as butter, bacon, cheese, or whole milk.
If you vomit shortly after taking Tibsovo, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Store at room temperature away from moisture and heat.
