Usual Adult Dose for Diabetes Type 2:
Standard glyburide:
-Initial dose: 2.5 mg to 5 mg orally once a day
-Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response
-Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses
-Maximum dose: 20 mg/day
Micronized glyburide:
-Initial dose: 1.5 mg to 3 mg orally once a day
-Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response
-Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses
-Maximum dose: 12 mg/day
Comments:
-Administer with breakfast or the first main meal of the day
-Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs
-Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses.
TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY:
-Oral Antidiabetic Therapy: No exact dosage relationships exists between standard glyburide, micronized glyburide, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed.
-Insulin:
--If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day.
--If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day.
--If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting glyburide at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Usual Geriatric Dose for Diabetes Type 2:
Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.
 Detailed Glyburide dosage information
