Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once or seek emergency medical attention if you have:
weak or shallow breathing, breathing that stops during sleep;
a light-headed feeling, like you might pass out;
confusion, loss of coordination, extreme weakness;
blurred vision, slurred speech;
liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
high levels of serotonin in the body--agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea;
low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
opioid withdrawal symptoms--shivering, goose bumps, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, muscle pain.
Serious breathing problems may be more likely in older adults and those who are debilitated or have wasting syndrome or chronic breathing disorders.
Common side effects may include:
dizziness, drowsiness, blurred vision, feeling drunk, trouble concentrating;
withdrawal symptoms;
tongue pain, redness or numbness inside your mouth;
nausea, vomiting, constipation;
headache, back pain;
fast or pounding heartbeats, increased sweating; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Buprenorphine/naloxone side effects (more detail)
