This medicine should be used only when you cannot use other antifungal medications. Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death.
Call your doctor at once if you have any signs of liver damage, such as nausea, vomiting, stomach pain, fever, tiredness, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Ketoconazole can also cause a serious heart problem. Call your doctor right away if you have fast or pounding heartbeats, shortness of breath, and sudden dizziness.
Before taking this medicine
You should not use ketoconazole if you are allergic to it, or if you have liver disease.
Some medicines can cause unwanted or dangerous effects when used with ketoconazole. Your doctor may change your treatment plan if you also use:
cisapride;
colchicine;
irinotecan;
methadone;
tolvaptan;
antipsychotic medicine--pimozide, lurasidone;
cholesterol medication--lovastatin, simvastatin, and others;
ergot medicine--dihydroergotamine, ergotamine, ergonovine, methylergonovine;
heart medication--disopyramide, dofetilide, dronedarone, eplerenone, felodipine, nisoldipine, quinidine, ranolazine; or
a sedative--alprazolam, midazolam, or triazolam.
Tell your doctor if you have ever had:
liver problems;
long QT syndrome (in you or a family member); or
problems with your adrenal gland.
It is not known whether  ketoconazole will harm an unborn baby. Tell your doctor if you are pregnant.
You should not breast-feed while using this medicine.
Do not give this medicine to a child without medical advice.
