Get emergency medical help if you have signs of an allergic reaction to Cymbalta: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
vision changes, eye pain or swelling, eye redness;
easy bruising, unusual bleeding;
painful or difficult urination;
a seizure;
manic episodes - racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative.
right-sided upper stomach pain, itching, dark urine, yellowing of the skin or eyes (signs of liver problems);
headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady (signs of low levels of sodium in the body); or
severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Older adults may be more sensitive to the side effects of this medicine.
Common Cymbalta side effects may include:
dry mouth;
drowsiness, dizziness;
tired feeling;
nausea, constipation, loss of appetite, weight loss; or
increased sweating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Cymbalta side effects (more detail)
