Usual Adult Dose for Pseudomembranous Colitis:
Clostridium difficile-associated diarrhea: 125 mg orally 4 times a day
-Duration of therapy: 10 days
Enterocolitis: 500 mg to 2 g orally per day, given in divided doses 3 to 4 times a day
-Maximum dose: 2 g/day
-Duration of therapy: 7 to 10 days
Comment: Formulations administered by injection will not treat colitis.
Uses:
-Treatment of C difficile-associated diarrhea
-Treatment of enterocolitis caused by S aureus (including MRSA)
Society of Healthcare Epidemiology of America (SHEA) and IDSA Recommendations:
Initial treatment of severe C difficile infection (CDI): 125 mg orally 4 times a day
-Duration of therapy: 10 to 14 days
Severe, complicated CDI: 500 mg orally 4 times a day AND 500 mg (in 100 mL normal saline) rectally every 6 hours with/without IV metronidazole
Comments:
-Rectal formulations should be administered as a retention enema.
-The first recurrence of CDI may be treated with the initial treatment regimen; a second recurrence of CDI may be treated with a tapered/pulsed regimen of this drug.
Uses:
-Initial treatment of patients with severe CDI
-Initial treatment of patients with complicated, severe CDI
Usual Adult Dose for Enterocolitis:
Clostridium difficile-associated diarrhea: 125 mg orally 4 times a day
-Duration of therapy: 10 days
Enterocolitis: 500 mg to 2 g orally per day, given in divided doses 3 to 4 times a day
-Maximum dose: 2 g/day
-Duration of therapy: 7 to 10 days
Comment: Formulations administered by injection will not treat colitis.
Uses:
-Treatment of C difficile-associated diarrhea
-Treatment of enterocolitis caused by S aureus (including MRSA)
Society of Healthcare Epidemiology of America (SHEA) and IDSA Recommendations:
Initial treatment of severe C difficile infection (CDI): 125 mg orally 4 times a day
-Duration of therapy: 10 to 14 days
Severe, complicated CDI: 500 mg orally 4 times a day AND 500 mg (in 100 mL normal saline) rectally every 6 hours with/without IV metronidazole
Comments:
-Rectal formulations should be administered as a retention enema.
-The first recurrence of CDI may be treated with the initial treatment regimen; a second recurrence of CDI may be treated with a tapered/pulsed regimen of this drug.
Uses:
-Initial treatment of patients with severe CDI
-Initial treatment of patients with complicated, severe CDI
 Detailed Vancomycin dosage information
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
