You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment).
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Get emergency medical help if you have unusual muscle pain, trouble breathing, irregular heartbeats, dizziness, vomiting, or if you feel cold, tired, or very weak.
Before taking this medicine
You should not use  Jentadueto XR if you are allergic to linagliptin (Tradjenta) or metformin, or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin).
Tell your doctor if you have ever had:
kidney disease;
heart disease;
liver disease;
pancreatitis;
gallstones;
alcoholism; or
high triglycerides (a type of fat in the blood).
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Jentadueto XR. Be sure your caregivers know ahead of time that you are using this medication.
Tell your doctor if you are pregnant or breastfeeding.
Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.
This medicine may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
This medicine is not approved for use by anyone younger than 18 years old.
