Smoking Cessation
Used for nicotine replacement therapy as a temporary adjunct in the cessation of cigarette smoking either unsupervised (self-medication)     or in conjunction with a behavior modification program under clinician supervision.                        
Nicotine replacement therapy considered one of several first-line therapies by USPHS for treatment of tobacco dependence. For additional information, consult the most current USPHS clinical practice guideline available at [Web]
Nicotine replacement therapy provides alternative sources of nicotine that help reduce the withdrawal symptoms associated with nicotine dependence.           Chewing the resin complex-containing gum may act as a substitute oral activity in behavior modification.
Electronic nicotine delivery systems (ENDS) such as electronic cigarettes (e-cigarettes) have been used to aid smoking cessation attempts; however, these products are not approved by FDA for this use and evidence is limited regarding their efficacy and safety.       The role of ENDS relative to conventional nicotine replacement therapies for smoking cessation remains to be established.   
Ulcerative Colitis
Transdermal nicotine has been used in the management of ulcerative colitis†.       
