You should not use Votrient if you have severe liver disease. Pazopanib can cause severe or life-threatening liver problems. You will need frequent blood tests to check your liver function.
Call your doctor at once if you have: nausea, vomiting, upper stomach pain, loss of appetite, tiredness, easy bruising, dark urine, or jaundice (yellowing of the skin or eyes).
Votrient can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
Before taking this medicine
To make sure Votrient is safe for you, tell your doctor if you have ever had:
liver disease;
heart disease, heart rhythm disorder, long QT syndrome;
high blood pressure;
a blood clot or stroke;
a thyroid disorder;
headaches, seizures, or vision problems;
a perforation (a hole or tear) in your stomach or intestines;
a fistula (an abnormal passageway) within your stomach or intestines;
stomach or intestinal bleeding; or
a surgery within the past 7 days.
You may need to have a negative pregnancy test before starting this treatment.
Do not use Votrient if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.
If you are a man whose sex partner is pregnant or could become pregnant, use condoms while taking Votrient, and for at least 2 weeks after your last dose. You should use condoms even if you have had a vasectomy.
You should not breastfeed while you are using Votrient, and for at least 2 weeks after your last dose.
How should I take Votrient?
Take Votrient exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Take Votrient on an empty stomach, at least 1 hour before or 2 hours after a meal.
Swallow the tablet whole and do not crush, chew, or break it.
Votrient can cause severe or life-threatening infections, liver problems, or high blood pressure. You will need frequent medical tests.
If you need surgery, tell the surgeon ahead of time that you are using pazopanib. You may need to stop using the medicine for at least 7 days before your surgery.
Store Votrient at room temperature away from moisture and heat.
