Get emergency medical help if you have signs of an allergic reaction to duloxetine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
pounding heartbeats or fluttering in your chest;
a light-headed feeling, like you might pass out;
easy bruising, unusual bleeding;
vision changes;
painful or difficult urination;
impotence, sexual problems;
liver problems - right-sided upper stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
manic episodes - racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common duloxetine side effects may include:
drowsiness;
nausea, constipation, loss of appetite;
dry mouth; or
increased sweating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
 Duloxetine side effects (more detail)
