Some drugs can make birth control less effective, which may result in pregnancy. Use a barrier form of birth control (a male condom with spermicide, but not a female condom) with the Annovera vaginal ring if you also use any of the following medicines:
aprepitant, bosentan, St. John's wort;
antifungal medicine;
antiviral medicine to treat hepatitis C or HIV/AIDS;
blood pressure medication;
seizure medicine;
steroid medicine;
thyroid medicine; or
tuberculosis medicine.
Keep using the barrier birth control for at least 28 days after your last dose of any of these medicines.
Annovera can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Some drugs can affect your blood levels of ethinyl estradiol and segesterone if you take them with grapefruit juice.
Tell your doctor about all your current medicines and any medicine you start or stop using. Many drugs can affect Annovera, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
 Ethinyl estradiol/segesterone drug interactions (more detail)
