Administration
Administer intranasally or topically to the eye.
Intranasal Administration
Administer intranasally twice daily, using a metered-dose nasal spray pump. Avoid spraying into the eyes.
Before initial use, prime the pump by releasing 5 sprays or until a fine mist appears. If nasal spray has not been used for >7 days, reprime the pump by releasing 2 sprays.
To actuate the pump, hold the bottle in one hand; with forefinger and middle finger on the shoulders of the pump unit and the thumb on the bottom of the bottle, press down on the shoulders of the pump to produce a fine mist.
Prior to administration, gently blow the nose to clear nasal passages. To administer, close one nostril; then, with head tipped down (chin toward chest), insert nasal applicator ¼ to ½ inch into the other nostril, hold bottle vertically upright, and aim spray tip toward the cheek side of the nose (away from the center of the nose). While gently breathing in through the nose, press firmly and quickly on the pump to release the spray. Breathe out through the mouth.
Do not tip head back or blow the nose immediately after dosing; tipping head back may produce a bitter taste in the mouth.
Repeat procedure for the other nostril. Alternate nostrils between each actuation.
Following administration, wipe nasal applicator with a clean tissue and replace the blue plastic cap.
If nasal applicator becomes clogged, do not attempt to clean by inserting a sharp object. Instead, remove nasal applicator by gently pulling it upward; once removed, wash (while pointing nasal applicator downward) by running warm tap water for about one minute. Shake the applicator to remove any water and place the applicator back on the bottle. Prime by spraying 2 times or until a fine mist appears.
Discard after 240 sprays.
Ophthalmic Administration
Apply topically to the eye as an ophthalmic solution. Not for injection or oral use.
If more than one topical ophthalmic drug is used, administer the drugs at least 5 minutes apart.
Avoid contamination of the solution container.
Dosage
Available as olopatadine hydrochloride; dosage expressed in terms of olopatadine.
Nasal spray delivers about 665 mcg of olopatadine hydrochloride (equivalent to 600 mcg of olopatadine) per metered spray and about 240 metered sprays per 30.5-g bottle.
Pediatric Patients
Allergic Conjunctivitis
Ophthalmic
0.1% ophthalmic solution: In children ≥3 years of age, 1 drop in the affected eye(s) twice daily (at an interval of 6–8 hours).
0.2% ophthalmic solution: In children ≥2 years of age, 1 drop in the affected eye(s) once daily.
Once symptomatic improvement is established, continue therapy for as long as necessary to sustain improvement.
Seasonal Allergic Rhinitis
Intranasal
Children 6–11 years of age: 1 spray (600 mcg) in each nostril twice daily.
Children ≥12 years of age: 2 sprays (1200 mcg) in each nostril twice daily.
Adults
Allergic Conjunctivitis
Ophthalmic
0.1% ophthalmic solution: 1 drop in the affected eye(s) twice daily (at an interval of 6–8 hours).
0.2% ophthalmic solution: 1 drop in the affected eye(s) once daily.
Once symptomatic improvement is established, continue therapy for as long as necessary to sustain improvement.
Seasonal Allergic Rhinitis
Intranasal
2 sprays (1200 mcg) in each nostril twice daily.
Special Populations
Hepatic Impairment
Nasal spray: Dosage adjustment not necessary.
Hepatic Impairment
Nasal spray: Dosage adjustment not necessary.
Geriatric Patients
Nasal spray: Select dosage with caution. (See Geriatric Use under Cautions.)
 Detailed Olopatadine ophthalmic dosage information
