Taking Pristiq with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Many drugs (including some over-the-counter medicines and herbal products) can increase your risk of bleeding if you take them with Pristiq, especially:
a blood thinner such as warfarin, or other medicine used to prevents blood clots; or
an NSAID (nonsteroidal anti-inflammatory drug) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete and many other drugs may affect Pristiq. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
 Pristiq drug interactions (more detail)
