Prezista is a protease (PRO-tee-ayz) inhibitor antiviral medicine that
prevents human immunodeficiency virus (HIV) from multiplying in your body.

Prezista is used to treat HIV, the virus that can cause acquired
immunodeficiency syndrome (AIDS).

Prezista must be given in combination with ritonavir and other antiviral
medications and should not be used alone.

Prezista is not a cure for HIV or AIDS.





Get emergency medical help if you have **signs of an allergic reaction to
Prezista** (hives, difficult breathing, swelling in your face or throat) **or
a severe skin reaction** (fever, sore throat, burning eyes, skin pain, red or
purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  * a skin rash, no matter how mild;

  * **high blood sugar** \- increased thirst, increased urination, dry mouth, fruity breath odor; or

  * **signs of liver or pancreas problems** \- loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Darunavir affects your immune system, which may cause certain side effects
(even weeks or months after you've taken this medicine). Tell your doctor if
you have:

  * **signs of a new infection** \- fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

  * trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

  * swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Prezista side effects may include:

  * nausea, vomiting, diarrhea, stomach pain;

  * headache;

  * rash; or

  * changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to
FDA at 1-800-FDA-1088.

Prezista side effects (more detail)