Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor
antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be
unbalanced in people with depression.

Cymbalta is used to treat major depressive disorder in adults. It is also used
to treat general anxiety disorder in adults and children who are at least 7
years old.

Cymbalta is also used in adults to treat nerve pain caused by diabetes
(diabetic neuropathy), or chronic muscle or joint pain (such as low back pain
and osteoarthritis pain).

Cymbalta is also used to treat fibromyalgia (a chronic pain disorder) in
adults and children at least 13 years old.





Get emergency medical help if you have **signs of an allergic reaction to
Cymbalta** (hives, difficult breathing, swelling in your face or throat) **or
a severe skin reaction** (fever, sore throat, burning eyes, skin pain, red or
purple skin rash with blistering and peeling).

**Tell your doctor right away if you have new or sudden changes in mood or
behavior, including** new or worse depression or anxiety, panic attacks,
trouble sleeping, or if you feel impulsive, irritable, agitated, hostile,
aggressive, restless, more active or talkative, or have thoughts about suicide
or hurting yourself.

Call your doctor at once if you have:

  * pounding heartbeats or fluttering in your chest;

  * a light-headed feeling, like you might pass out;

  * easy bruising, unusual bleeding;

  * vision changes;

  * painful or difficult urination;

  * **liver problems** \- right-sided upper stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);

  * **low blood sodium** \- headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or

  * **manic episodes** \- racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative.

**Seek medical attention right away if you have symptoms of serotonin
syndrome, such as:** agitation, hallucinations, fever, sweating, shivering,
fast heart rate, muscle stiffness, twitching, loss of coordination, nausea,
vomiting, or diarrhea.

Common Cymbalta side effects may include:

  * drowsiness;

  * nausea, constipation, loss of appetite;

  * dry mouth; or

  * increased sweating.

This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to
FDA at 1-800-FDA-1088.

Cymbalta side effects (more detail)