Complera contains a combination of emtricitabine, rilpivirine, and tenofovir.
Emtricitabine, rilpivirine, and tenofovir are antiviral medicines that prevent
human immunodeficiency virus (HIV) from multiplying in your body. HIV causes
acquired immunodeficiency syndrome (AIDS).

Complera is used to treat HIV in people who have never taken HIV medicines
before. This medicine is for use in adults and children who are at least 12
years old.

Complera is not a cure for HIV or AIDS.

Complera should not be taken together with other antiviral medications to
treat HIV or AIDS.





Get emergency medical help if you have **signs of an allergic reaction to
Complera:** hives, blistering skin rash with fever; mouth sores, eye redness;
difficulty breathing; swelling of your face, lips, tongue, or throat.

Some people develop lactic acidosis while taking HIV medication. Early
symptoms may get worse over time and this condition can be fatal. Get
emergency medical help if you have even mild symptoms such as: muscle pain or
weakness, numb or cold feeling in your arms and legs, trouble breathing,
stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or
feeling very weak or tired.

Call your doctor at once if you have:

  * confusion, severe depression, unusual thoughts or behavior, suicidal thoughts or actions;

  * increased thirst and urination, loss of appetite, weakness, constipation;

  * **kidney problems** \- little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

  * **liver problems** \- swelling around your midsection, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  * **signs of inflammation in your body** \- swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough with fever, trouble breathing;

Complera may increase your risk of certain infections or autoimmune disorders
by changing the way your immune system works. Symptoms may occur weeks or
months after you start treatment. Tell your doctor if you have:

  * **signs of a new infection** \- fever, night sweats, swollen glands, diarrhea, weight loss;

  * chest pain (especially when you breathe), dry cough, wheezing;

  * cold sores, sores on your genital or anal area;

  * feeling anxious or irritable, weakness or prickly feeling, problems with balance or eye movement;

  * trouble speaking or swallowing, severe lower back pain, loss of bladder or bowel control; or

  * swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

Common Complera side effects may include:

  * headache, dizziness, tiredness;

  * depressed mood, sleep problems (insomnia), strange dreams;

  * rash;

  * nausea, diarrhea; or

  * changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your
doctor for medical advice about side effects. You may report side effects to
FDA at 1-800-FDA-1088.

Complera side effects (more detail)