A 53-year-old male patient, diagnosed with ankylopoietic spondylitis (HLA B27), secondary amyloidosis and terminal chronic renal failure on replacement treatment with haemodialysis. He presented with painless haematuria and cystoscopy revealed a bladder mass, excrescent but not papillary and bleeding. Transurethral resection (TUR) was performed and the histological diagnosis was bladder amyloidosis. The patient evolved satisfactorily and after 11 months he was readmitted with intense, epigastric and fixed abdominal pain, to which was added two hours later a sudden, abundant and haematic vomiting, which was complicated by cardiorespiratory arrest, leading to exitus (11/04/1995). Post-mortem anatomopathological diagnosis revealed ischaemic necrosis of the digestive tract in the territory irrigated by the superior mesenteric artery and amyloid deposits in the submucosal vessels. Organ and system involvement was widespread, including bilateral renal atrophy due to amyloidosis. Bladder amyloidosis (AA), mostly perivascular and amyloidosis in prostatic vessels.