import os

from tqdm import tqdm

import re

from random import shuffle

#import ipdb

def byLineReader(filename):

    with open(filename, "r", encoding="utf-8") as f:

        line = f.readline()

        while line:

            yield line

            line = f.readline()

    return

class UMLS(object):

    def __init__(self, umls_path, source_range=None, lang_range=['ENG'], only_load_dict=False):

        self.umls_path = umls_path

        self.source_range = source_range

        self.lang_range = lang_range

        self.detect_type()

        self.load()

        if not only_load_dict:

            self.load_rel()

            self.load_sty()

    def detect_type(self):

        if os.path.exists(os.path.join(self.umls_path, "MRCONSO.RRF")):

            self.type = "RRF"

        else:

            self.type = "txt"

    def load(self):

        reader = byLineReader(os.path.join(self.umls_path, "MRCONSO." + self.type))

        self.lui_set = set()

        self.cui2str = {}

        self.str2cui = {}

        self.code2cui = {}

        #self.lui_status = {}

        read_count = 0

        for line in tqdm(reader, ascii=True):

            if self.type == "txt":

                l = [t.replace("\"", "") for t in line.split(",")]

            else:

                l = line.strip().split("|")

            cui = l[0]

            lang = l[1]

            # lui_status = l[2].lower() # p -> preferred

            lui = l[3]

            source = l[11]

            code = l[13]

            string = l[14]

            if (self.source_range is None or source in self.source_range) and (self.lang_range is None or lang in self.lang_range):

                if not lui in self.lui_set:

                    read_count += 1

                    self.str2cui[string] = cui

                    self.str2cui[string.lower()] = cui

                    clean_string = self.clean(string)

                    self.str2cui[clean_string] = cui

                    if not cui in self.cui2str:

                        self.cui2str[cui] = set()

                    self.cui2str[cui].update([clean_string])

                    self.code2cui[code] = cui

                    self.lui_set.update([lui])

            # For debug

            # if read_count > 1000:

            #     break

        self.cui = list(self.cui2str.keys())

        shuffle(self.cui)

        self.cui_count = len(self.cui)

        print("cui count:", self.cui_count)

        print("str2cui count:", len(self.str2cui))

        print("MRCONSO count:", read_count)

    def load_rel(self):

        reader = byLineReader(os.path.join(self.umls_path, "MRREL." + self.type))

        self.rel = set()

        for line in tqdm(reader, ascii=True):

            if self.type == "txt":

                l = [t.replace("\"", "") for t in line.split(",")]

            else:

                l = line.strip().split("|")

            cui0 = l[0]

            re = l[3]

            cui1 = l[4]

            rel = l[7]

            if cui0 in self.cui2str and cui1 in self.cui2str:

                str_rel = "\t".join([cui0, cui1, re, rel])

                if not str_rel in self.rel and cui0 != cui1:

                    self.rel.update([str_rel])

            # For debug

            # if len(self.rel) > 1000:

            #     break

        self.rel = list(self.rel)

        print("rel count:", len(self.rel))

    def load_sty(self):

        reader = byLineReader(os.path.join(self.umls_path, "MRSTY." + self.type))

        self.cui2sty = {}

        for line in tqdm(reader, ascii=True):

            if self.type == "txt":

                l = [t.replace("\"", "") for t in line.split(",")]

            else:

                l = line.strip().split("|")

            cui = l[0]

            sty = l[3]

            if cui in self.cui2str:

                self.cui2sty[cui] = sty

        print("sty count:", len(self.cui2sty))

    def clean(self, term, lower=True, clean_NOS=True, clean_bracket=True, clean_dash=True):

        term = " " + term + " "

        if lower:

            term = term.lower()

        if clean_NOS:

            term = term.replace(" NOS ", " ").replace(" nos ", " ")

        if clean_bracket:

            term = re.sub(u"\\(.*?\\)", "", term)

        if clean_dash:

            term = term.replace("-", " ")

        term = " ".join([w for w in term.split() if w])

        return term

    def search_by_code(self, code):

        if code in self.cui2str:

            return list(self.cui2str[code])

        if code in self.code2cui:

            return list(self.cui2str[self.code2cui[code]])

        return None

    def search_by_string_list(self, string_list):

        for string in string_list:

            if string in self.str2cui:

                find_string = self.cui2str[self.str2cui[string]]

                return [string for string in find_string if not string in string_list]

            if string.lower() in self.str2cui:

                find_string = self.cui2str[self.str2cui[string.lower()]]

                return [string for string in find_string if not string in string_list]

        return None

    def search(self, code=None, string_list=None, max_number=-1):

        result_by_code = self.search_by_code(code)

        if result_by_code is not None:

            if max_number > 0:

                return result_by_code[0:min(len(result_by_code), max_number)]

            return result_by_code

        return None

        result_by_string = self.search_by_string_list(string_list)

        if result_by_string is not None:

            if max_number > 0:

                return result_by_string[0:min(len(result_by_string), max_number)]

            return result_by_string

        return None

if __name__ == "__main__":

    umls = UMLS("E:\\code\\research\\umls")

    # print(umls.search_by_code("282299006"))

    #print(umls.search_by_string_list(["Backache", "aching muscles in back"]))

    #print(umls.search(code="95891005", max_number=10))

    # ipdb.set_trace()

"""

['unable to balance', 'loss of balance']

['backache', 'back pain', 'dorsalgi', 'dorsodynia', 'pain over the back', 'back pain [disease/finding]', 'back ache', 'dorsal back pain', 'backach', 'dorsalgia', 'dorsal pain', 'notalgia', 'unspecified back pain', 'backpain', 'backache symptom']

['influenza like illness', 'flu-like illness', 'influenza-like illness']

"""