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| # | Title | Abstract | Journal | Language | Year | Month | Authors | Affiliations | Name | Abbr Name | ISSN | EISSN | Impact_Factor | Impact_Factor_5Years | Journal_Category | Universities | Study_Type_Extracted | Standardized_University | Rank | Research_Score | Rank_Median | Research_Score_Category | |
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| 1 | 0 | prevalence and association of sleep duration and different volumes of physical activity with type 2 diabetes: the first evidence from charls. | this study aimed to examine the prevalence of type 2 diabetes (t2d) and the independent and joint associations of sleep duration and different volumes of physical activity (pa) with t2d in the china health and retirement longitudinal study (charls). | bmc public health | eng | 2024 | Nov | Zhou Zigui, Tian Xuewen | school of exercise and health, shanghai university of sport, 200 hengren road, yangpu district, shanghai, 200438, china., school of exercise and health, shanghai university of sport, 200 hengren road, yangpu district, shanghai, 200438, china. xuewentian1978@163.com. | bmc public health | bmc public health | 1471-2458 | 3.5 | 3.9 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH|Q1|84/403 | school of exercise and health, shanghai university of sport, school of exercise and health, shanghai university of sport | Unknown | shanghai university | 501–600 | 38.0 | 550.5 | Low (0-50) | |
| 2 | 1 | the impact of pparγ and apoe gene polymorphisms on susceptibility to diabetic kidney disease in type 2 diabetes mellitus: a meta-analysis. | globally, diabetic kidney disease (dkd) has become the leading cause of end-stage renal disease, imposing substantial social and economic costs. this meta-analysis was designed to provide valuable insights into gene-disease interactions by investigating the potential association between lipid metabolism gene polymorphisms and the risk of dkd. | bmc nephrology | eng | 2024 | Nov | Taurbekova Binura, Mukhtarova Kymbat, Salpynov Zhandos, Atageldiyeva Kuralay, Sarria-Santamera Antonio | department of biomedical sciences, school of medicine, nazarbayev university, astana, kazakhstan. binura.taurbekova@nu.edu.kz., department of biomedical sciences, school of medicine, nazarbayev university, astana, kazakhstan., department of surgery, school of medicine, nazarbayev university, astana, kazakhstan., department of medicine, school of medicine, nazarbayev university, astana, kazakhstan., department of biomedical sciences, school of medicine, nazarbayev university, astana, kazakhstan. | bmc nephrology | bmc nephrol | 1471-2369 | 2.2 | 2.6 | UROLOGY & NEPHROLOGY|Q2|54/126 | school of medicine, nazarbayev university, school of medicine, nazarbayev university, school of medicine, nazarbayev university, school of medicine, nazarbayev university, school of medicine, nazarbayev university | meta-analysis | nazarbayev university | 501–600 | 29.5 | 550.5 | Low (0-50) | |
| 3 | 2 | immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors. | immune checkpoint inhibitor (ici) therapies can increase the risk of cardiovascular events in survivors of cancer by worsening atherosclerosis. here we map the expression of immune checkpoints (ics) within human carotid and coronary atherosclerotic plaques, revealing a network of immune cell interactions that ici treatments can unintentionally target in arteries. we identify a population of mature, regulatory ccr7<sup>+</sup>fscn1<sup>+</sup> dendritic cells, similar to those described in tumors, as a hub of ic-mediated signaling within plaques. additionally, we show that type 2 diabetes and lipid-lowering therapies alter immune cell interactions through pd-1, ctla4, lag3 and other ic targets in clinical development, impacting plaque inflammation. this comprehensive map of the ic interactome in healthy and cardiometabolic disease states provides a framework for understanding the potential adverse and beneficial impacts of approved and investigational icis on atherosclerosis, setting the stage for designing ici strategies that minimize cardiovascular disease risk in cancer survivors. | nature cardiovascular research | eng | 2024 | Nov | Barcia Durán José Gabriel, Das Dayasagar, Gildea Michael, Amadori Letizia, Gourvest Morgane, Kaur Ravneet, Eberhardt Natalia, Smyrnis Panagiotis, Cilhoroz Burak, Sajja Swathy, Rahman Karishma, Fernandez Dawn M, Faries Peter, Narula Navneet, Vanguri Rami, Goldberg Ira J, Fisher Edward A, Berger Jeffrey S, Moore Kathryn J, Giannarelli Chiara | nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., division of cardiology, department of medicine, icahn school of medicine at mount sinai, new york, ny, usa., division of cardiology, department of medicine, icahn school of medicine at mount sinai, new york, ny, usa., department of surgery, vascular division, icahn school of medicine at mount sinai, new york, ny, usa., department of pathology, new york university grossman school of medicine, new york university langone health, new york, ny, usa., division of precision medicine, department of medicine, new york university grossman school of medicine, new york, ny, usa., division of endocrinology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa. kathryn.moore@nyulangone.org., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa. chiara.giannarelli@nyulangone.org. | nature cardiovascular research | nat cardiovasc res | 2731-0590 | 9.4 | 9.4 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q1|13/220 | nyu cardiovascular research center, department of medicine, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, department of medicine, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, department of medicine, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, division of cardiology, icahn school of medicine, division of cardiology, icahn school of medicine, icahn school of medicine, new york university, grossman school of medicine, new york university langone health | clinical development | york university | 351–400 | 32.4 | 375.5 | Low (0-50) | |
| 4 | 3 | ezrin drives adaptation of monocytes to the inflamed lung microenvironment. | ezrin, an actin-binding protein, orchestrates the organization of the cortical cytoskeleton and plasma membrane during cell migration, adhesion, and proliferation. its role in monocytes/macrophages (mφs) is less understood. here, we used a monocyte/mφ-specific ezrin knock-out mouse model to investigate the contribution of ezrin to monocyte recruitment and adaptation to the lung extracellular matrix (ecm) in response to lipopolysaccharide (lps). our study revealed that lps induces ezrin expression in monocytes/mφs and is essential for monocytes to adhere to lung ecm, proliferate, and differentiate into tissue-resident interstitial mφs. mechanistically, the loss of ezrin in monocytes disrupts activation of focal adhesion kinase and akt serine-threonine protein kinase signaling, essential for lung-recruited monocytes and monocyte-derived mφs to adhere to the ecm, proliferate, and survive. in summary, our data show that ezrin plays a role beyond structural cellular support, influencing diverse monocytes/mφ processes and signaling pathways during inflammation, facilitating their differentiation into tissue-resident macrophages. | cell death & disease | eng | 2024 | Nov | Gudneppanavar Ravindra, Di Pietro Caterina, H Öz Hasan, Zhang Ping-Xia, Cheng Ee-Chun, Huang Pamela H, Tebaldi Toma, Biancon Giulia, Halene Stephanie, Hoppe Adam D, Kim Catherine, Gonzalez Anjelica L, Krause Diane S, Egan Marie E, Gupta Neetu, Murray Thomas S, Bruscia Emanuela M | department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., yale stem cell center, school of medicine, yale university, new haven, ct, usa., yale stem cell center, school of medicine, yale university, new haven, ct, usa., yale stem cell center, school of medicine, yale university, new haven, ct, usa., department of chemistry and biochemistry, south dakota state university, brookings, sd, usa., department of biomedical engineering, yale university, new haven, ct, usa., department of biomedical engineering, yale university, new haven, ct, usa., yale stem cell center, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of inflammation and immunity, cleveland clinic foundation, cleveland, oh, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa., department of pediatrics, school of medicine, yale university, new haven, ct, usa. emanuela.bruscia@yale.edu. | cell death & disease | cell death dis | 2041-4889 | 2041-4889 | 8.1 | 8.6 | CELL BIOLOGY|Q1|33/205 | school of medicine, yale university, school of medicine, yale university, school of medicine, yale university, school of medicine, yale university, school of medicine, yale university, school of medicine, yale university, yale stem cell center, school of medicine, yale university, yale stem cell center, school of medicine, yale university, yale stem cell center, school of medicine, yale university, south dakota state university, yale university, yale university, yale stem cell center, school of medicine, yale university, school of medicine, yale university, cleveland clinic foundation, school of medicine, yale university, school of medicine, yale university | Unknown | yale university | 10 | 94.9 | 10.0 | High (75-100) |
| 5 | 4 | determining the quality of life and associated factors in patients with pressure injury. | this study aimed to determine the quality of life of patients with pressure injuries and the factors associated with them. | journal of tissue viability | eng | 2024 | Nov | Gül Şenay, Demir Ayşe Sılanur, Karadağ Ayişe, Karaçay Pelin | faculty of nursing, hacettepe university, ankara, turkiye. electronic address: senaygundogmus@gmail.com., school of nursing, koc university, i̇stanbul, turkiye., school of nursing, koc university, i̇stanbul, turkiye., school of nursing, koc university, i̇stanbul, turkiye. | journal of tissue viability | j tissue viability | 0965-206X | 1876-4746 | 2.4 | 2.9 | NURSING|Q1|35/191 | hacettepe university, koc university, school of nursing, koc university, school of nursing, koc university | Unknown | hacettepe university | 601–800 | 26.8 | 700.5 | Low (0-50) |
| 6 | 5 | investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (ver-a-t1d): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. | type 1 diabetes mellitus (t1dm) is a disorder that arises following the selective autoimmune destruction of the insulin-producing beta cells. beta-cell protective or beta-cell regenerative approaches have gained wider attention, and pharmacological approaches to protect the patient's own insulin-producing beta-cell mass have been proposed. verapamil is an l-type calcium channel blocker that has been reported to effectively lowers beta-cell thioredoxin-interacting protein expression in rodent beta cells and islets, as well as in human islets, and thus promotes functional beta-cell mass. | bmj open | eng | 2024 | Nov | Wych Julie, Brunner Martina, Stenson Rachel, Chmura Piotr Jaroslaw, Danne Thomas, Mander Adrian Paul, Mathieu Chantal, Dayan Colin, Pieber Thomas R | centre for trials research, cardiff university, cardiff, uk wychj@cardiff.ac.uk., department of internal medicine, division of endocrinology and diabetology, medical university of graz, graz, austria., diabetes research group, cardiff university, cardiff, uk., center for protein research, kobenhavns universitet sundhedsvidenskabelige fakultet, kobenhavn, denmark., department of general pediatrics endocrinology/diabetology & clinical research, auf der bult children's hospital, hannover, germany., centre for trials research, cardiff university, cardiff, uk., katholieke universiteit leuven, uz leuven, leuven, belgium., cardiff university school of medicine, cardiff university, cardiff, uk., department of internal medicine, division of endocrinology and diabetology, medical university of graz, graz, austria. | bmj open | bmj open | 2044-6055 | 2044-6055 | 2.4 | 2.7 | MEDICINE, GENERAL & INTERNAL|Q1|80/325 | cardiff university, division of endocrinology and diabetology, medical university of graz, cardiff university, kobenhavns universitet sundhedsvidenskabelige fakultet, cardiff university, katholieke universiteit leuven, cardiff university, cardiff university, division of endocrinology and diabetology, medical university of graz | Unknown | cardiff university | 190 | 39.6 | 190.0 | Low (0-50) |
| 7 | 6 | association between adipose deposition and mortality among adults without major cardiovascular risk factors. | to examine the association between adiposity and mortality in u.s. adults without major cardiovascular risk factors. | diabetes & metabolism | eng | 2024 | Nov | Claudel Sophie E, Verma Ashish | department of medicine, boston medical center, boston, ma, usa., department of medicine, section of nephrology, boston university chobanian & avedisian school of medicine, boston, ma, usa. electronic address: ashverma@bu.edu. | diabetes & metabolism | diabetes metab | 1262-3636 | 1878-1780 | 4.6 | 5.1 | ENDOCRINOLOGY & METABOLISM|Q1|36/186 | department of medicine, boston medical center, department of medicine, boston university chobanian & avedisian school of medicine | Unknown | boston university | 78 | 54.1 | 78.0 | Medium (50-75) |
| 8 | 7 | a preliminary assessment of barriers and facilitators to accessing footcare in homeless shelters: a scoping review. | by examining the scientific literature, this scoping review aims to explore the most common foot problems people experiencing homelessness (peh) experience, as well as to explore the potential strategies for addressing foot problems in peh, such as foot clinics, foot screening and foot care for adults experiencing homelessness. | annals of vascular surgery | eng | 2024 | Nov | Benadda Imen, Lozano-Franco Rebecca, Coutu Félix-Antoine, Wells Sarah, Ades Matthew, Nauche Bénédicte, Drudi Laura M | faculty of medicine and health sciences, mcgill university, montreal, qc., faculty of medicine and health sciences, mcgill university, montreal, qc., faculty of medicine and health sciences, mcgill university, montreal, qc., innovation hub, centre de recherche du centre hospitalier de montréal, montréal, qc., department of medicine, mcgill university, division of general internal medicine, montréal, qc., medical libraries, centre hospitalier de l'université de montréal, montréal, qc., innovation hub, centre de recherche du centre hospitalier de montréal, montréal, qc; division of vascular surgery, centre hospitalier de l'université de montréal montréal, qc. electronic address: laura.drudi.med@ssss.gouv.qc.ca. | annals of vascular surgery | ann vasc surg | 0890-5096 | 1615-5947 | 1.4 | 1.4 | SURGERY|Q3|165/290 | faculty of medicine and health sciences, mcgill university, faculty of medicine and health sciences, mcgill university, faculty of medicine and health sciences, mcgill university, mcgill university, centre hospitalier de l'université de montréal, centre hospitalier de l'université de montréal | scoping review | mcgill university | 49 | 72.3 | 49.0 | Medium (50-75) |
| 9 | 8 | elevated lipid accumulation product trajectory patterns are associated with increasing incident risk of type 2 diabetes mellitus in china. | our study aimed to identify the trajectory patterns of lipid accumulation product (lap) and investigate their association with the incident risk of type 2 diabetes mellitus (t2dm) in china. | preventive medicine | eng | 2024 | Nov | Wu Yuying, Zhang Yanyan, Zhao Yang, Zhang Xing, Gu Minqi, Huo Weifeng, Fu Xueru, Li Xi, Guo Botang, Li Jianxin, Lu Xiangfeng, Hu Fulan, Hu Dongsheng, Zhang Ming | department of biostatistics and epidemiology, school of public health, shenzhen university medical school, shenzhen, guangdong, pr china., department of epidemiology, center for global health, school of public health, nanjing medical university, nanjing, jiangsu, pr china., department of general practice, affiliated luohu hospital of shenzhen university medical school, shenzhen, guangdong, pr china., department of biostatistics and epidemiology, school of public health, shenzhen university medical school, shenzhen, guangdong, pr china., department of biostatistics and epidemiology, school of public health, shenzhen university medical school, shenzhen, guangdong, pr china., department of epidemiology and biostatistics, college of public health, zhengzhou university, zhengzhou, henan, pr china., department of epidemiology and biostatistics, college of public health, zhengzhou university, zhengzhou, henan, pr china., department of epidemiology and biostatistics, college of public health, zhengzhou university, zhengzhou, henan, pr china., department of general practice, affiliated luohu hospital of shenzhen university medical school, shenzhen, guangdong, pr china., key laboratory of cardiovascular epidemiology, chinese academy of medical sciences, department of epidemiology, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, pr china., key laboratory of cardiovascular epidemiology, chinese academy of medical sciences, department of epidemiology, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, pr china., department of biostatistics and epidemiology, school of public health, shenzhen university medical school, shenzhen, guangdong, pr china., department of biostatistics and epidemiology, school of public health, shenzhen university medical school, shenzhen, guangdong, pr china; department of general practice, affiliated luohu hospital of shenzhen university medical school, shenzhen, guangdong, pr china., department of biostatistics and epidemiology, school of public health, shenzhen university medical school, shenzhen, guangdong, pr china. electronic address: zhangming1720@sina.com. | preventive medicine | prev med | 0091-7435 | 1096-0260 | 4.3 | 4.2 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH|Q1|47/403 | shenzhen university medical school, nanjing medical university, luohu hospital, shenzhen university medical school, shenzhen university medical school, shenzhen university medical school, zhengzhou university, zhengzhou university, zhengzhou university, luohu hospital, shenzhen university medical school, chinese academy of medical sciences, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences, peking union medical college, chinese academy of medical sciences, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences, peking union medical college, shenzhen university medical school, shenzhen university medical school, luohu hospital, shenzhen university medical school, shenzhen university medical school | Unknown | shenzhen university | 351–400 | 34.3 | 375.5 | Low (0-50) |
| 10 | 9 | general practice sleep scale - the "gpss" - a proposed new tool for use in general practice for risk assessment of obstructive sleep apnoea. | this pilot study investigated a new simplified osa screening tool that could be used in primary care/gp settings - the "gpss" tool - "general practice sleep scale" and compared against common existing osa screening tools. | sleep medicine | eng | 2024 | Nov | Howarth Timothy, Hedger Joe, Chen Winnie, Garg Himanshu, Heraganahally Subash S | darwin respiratory and sleep health, darwin private hospital, darwin, northern territory, australia; department of technical physics, university of eastern finland, kuopio, finland., flinders university, college of medicine and public health, darwin, northern territory, australia., flinders university, college of medicine and public health, darwin, northern territory, australia; general practice, danila dilba, aboriginal health service, darwin, northern territory, australia; menzies school of health research, darwin, northern territory, australia., department of respiratory and sleep medicine, royal darwin hospital, darwin, northern territory, australia., darwin respiratory and sleep health, darwin private hospital, darwin, northern territory, australia; department of respiratory and sleep medicine, royal darwin hospital, darwin, northern territory, australia; school of medicine, charles darwin university, darwin, northern territory, australia. electronic address: subash.heraganahally@nt.gov.au. | sleep medicine | sleep med | 1389-9457 | 1878-5506 | 3.8 | 4.0 | CLINICAL NEUROLOGY|Q1|59/277 | darwin private hospital, university of eastern finland, flinders university, college of medicine and public health, flinders university, college of medicine and public health, aboriginal health service, menzies school of health research, royal darwin hospital, darwin private hospital, royal darwin hospital, charles darwin university | pilot study | flinders university | 301–350 | 35.4 | 325.5 | Low (0-50) |
| 11 | 10 | association between serum uric acid and prediabetes in a normal chinese population: a cross-sectional study. | cardiovascular events are frequent among individuals with prediabetes. and the relationship between cardiovascular diseases and elevated serum uric acid (sua) levels has been supported by extensive scientific evidence. however, there remains controversy regarding the correlation between elevated sua and prediabetes. the aim of this study was to investigate the association between elevated sua levels and the prevalence of prediabetes and gender differences in the association. a total of 190,891 individuals who participated in health checkups at the health promotion center of sir run run shaw hospital of zhejiang university from january 2017 to december 2021 were included in this cross-sectional study. the health checkups were carried out by trained general practitioners and nurses. the diagnostic criteria for diabetes and prediabetes are defined in the standards of medical care in diabetes-2022. the association between sua levels and diabetes and prediabetes was examined based on logistic regression analysis. the dose-response effect between sua levels and diabetes and prediabetes in both sexes was assessed using a restricted cubic spline (rcs) regression model. among 190,891 participants, this study included 106,482 males (55.8%) and 84,409 females (44.2%). there were 46,240 (24.2%) patients with prediabetes and 20,792 (10.9%) patients with diabetes. sua was divided into quartiles (q). compared to the sua q1 group, the prevalence of prediabetes was elevated in the sua q4 group (or = 1.378, 95% ci = 1.321-1.437), but diabetes risk was decreased in the sua q4 group (or = 0.690, 95% ci = 0.651-0.730). we found that sua levels were correlated with prediabetes more significantly in male subjects (or = 1.328, 95% ci = 1.272-1.386) than in female subjects (or = 1.184, 95% ci = 1.122-1.249) (p for interaction < .001). higher sua levels were strongly related to an elevated prevalence of prediabetes but a decreased prevalence of diabetes. the association of sua in prediabetes was more significant in men. | medicine | eng | 2024 | Nov | Shen Keqing, Huang Yilin, Zhang Junlu, Chen Liangli, Cai Xixuan, Pan Jianjiang, Li Jingyi, Li Lusha, Chen Liying | department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of pathology, second affiliated hospital of wenzhou medical university, wenzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china., department of general practice, sir run run shaw hospital, school of medicine, zhejiang university, hangzhou, zhejiang, china. | medicine | medicine | 0025-7974 | 1536-5964 | 1.3 | 1.6 | MEDICINE, GENERAL & INTERNAL|Q2|143/325 | school of medicine, zhejiang university, school of medicine, zhejiang university, school of medicine, zhejiang university, wenzhou medical university, school of medicine, zhejiang university, school of medicine, zhejiang university, school of medicine, zhejiang university, school of medicine, zhejiang university, school of medicine, zhejiang university | cross-sectional study | zhejiang university | 55 | 75.3 | 55.0 | High (75-100) |
| 12 | 11 | a comprehensive review of biomarker research in diabetic nephropathy from a global bibliometric and visualization perspective. | diabetic nephropathy (dn) is a common complication of diabetes, which is prone to develop into end-stage renal disease, and early diagnosis and treatment is the key to effective management of dn. biomarkers have important clinical significance in the diagnosis and treatment of dn and have attracted extensive attention from researchers in recent years. the aim of this study was to visualize the field of biomarker research in dn through bibliometric analysis, to summarize the current status and predict future trends of this field, with a view to providing valuable insights for scholars and policy makers. | medicine | eng | 2024 | Nov | Li Qin, Xie Yafei, Zuo Meiying, Li Fang | hunan university of medicine, huaihua, china., the first clinical medical college of lanzhou university, lanzhou, china., the first clinical medical college of lanzhou university, lanzhou, china., hunan university of medicine, huaihua, china. | medicine | medicine | 0025-7974 | 1536-5964 | 1.3 | 1.6 | MEDICINE, GENERAL & INTERNAL|Q2|143/325 | hunan university of medicine, lanzhou university, lanzhou university, hunan university of medicine | Unknown | hunan university | 351–400 | 30.4 | 375.5 | Low (0-50) |
| 13 | 12 | cross-sectional and longitudinal associations between glycaemic measures and grip strength in people without diabetes in the uk biobank cohort study. | to investigate associations between glycaemic measures (hba1c, random glucose), and grip strength (gs) in adults without prevalent diabetes. | european geriatric medicine | eng | 2024 | Nov | Granic Antoneta, Cooper Rachel, Hurst Christopher, Hillman Susan J, Dodds Richard M, Witham Miles D, Sayer Avan A | age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk. antoneta.granic@newcastle.ac.uk., age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk., age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk., age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk., age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk., age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk., age research group, translational and clinical research institute, faculty of medical sciences, newcastle university, the health innovation neighbourhood, biomedical research building, newcastle upon tyne, ne4 5pl, uk. | european geriatric medicine | eur geriatr med | 1878-7649 | 1878-7657 | 3.5 | 3.2 | GERIATRICS & GERONTOLOGY|Q2|29/74 | faculty of medical sciences, newcastle university, faculty of medical sciences, newcastle university, faculty of medical sciences, newcastle university, faculty of medical sciences, newcastle university, faculty of medical sciences, newcastle university, faculty of medical sciences, newcastle university, faculty of medical sciences, newcastle university | Unknown | newcastle university | 168 | 41.1 | 168.0 | Low (0-50) |
| 14 | 13 | baseline characteristics of the discover ckd prospective cohort. | real-world data from patients with chronic kidney disease (ckd) are limited, particularly regarding clinical management, treatment patterns and health-related quality of life (hrqol) in the context of new therapies and updated standard of care guidelines. | advances in therapy | eng | 2024 | Nov | Pollock Carol, Carrero Juan-Jesus, Kanda Eiichiro, Ofori-Asenso Richard, Chen Hungta, Garcia Sanchez Juan Jose, Pentakota Surendra, Pecoits-Filho Roberto, Fishbane Steven, Lam Carolyn S P, Kashihara Naoki, Wheeler David C | kolling institute, royal north shore hospital, university of sydney, 10 westbourne st, st leonards, sydney, nsw, 2064, australia. carol.pollock@sydney.edu.au., department of medical epidemiology and biostatistics, karolinska institutet, solna, sweden., department of health data science, kawasaki medical school, kurashiki, okayama, japan., cardiovascular, renal, metabolism epidemiology, biopharmaceuticals medical, astrazeneca, cambridge, uk., medical and payer evidence statistics, biopharmaceuticals medical, astrazeneca, gaithersburg, md, usa., global market access and pricing, astrazeneca, barcelona, spain., global medical affairs, biopharmaceuticals medical, astrazeneca, cambridge, uk., school of medicine, pontifical catholic university of parana, curitiba, brazil., division of nephrology, zucker school of medicine, great neck, ny, usa., national heart centre singapore, singapore, singapore., department of nephrology, kawasaki medical school, okayama, japan., department of renal medicine, university college london, london, uk. | advances in therapy | adv ther | 0741-238X | 1865-8652 | 3.4 | 4.0 | PHARMACOLOGY & PHARMACY|Q2|105/354 | royal north shore hospital, university of sydney, karolinska institutet, kawasaki medical school, school of medicine, pontifical catholic university of parana, zucker school of medicine, national heart centre singapore, kawasaki medical school, university college london | treatment patterns | karolinska institute | 50 | 67.9 | 50.0 | Medium (50-75) |
| 15 | 14 | the role of anti-aging approaches in managing hypogonadism in sedentary older males. | with thirty percent of the world's population not getting enough exercise, worldwide, physical inactivity ranks as one of the most common causes of premature mortality. rapid drops in physical activity, decreased mobility, and early morbidity are aging characteristics. as the population over 80 continues to rise, aging raises the danger of age-related illnesses and changes in hormone release. | frontiers in aging | eng | 2024 | No Data | Abdel-Sater Khaled A | faculty of dentistry, mutah university, karak, jordan. | frontiers in aging | front aging-lausanne | 2673-6217 | 3.3 | 3.4 | GERIATRICS & GERONTOLOGY|Q2|35/74 | faculty of dentistry, mutah university | Unknown | mutah university | 1201–1500 | 11.5 | 1350.5 | Low (0-50) | |
| 16 | 15 | unleashing the potential of extracellular vesicles for ulcerative colitis and crohn's disease therapy. | image 1. | bioactive materials | eng | 2025 | Mar | Njoku George Chigozie, Forkan Cathal Patrick, Soltysik Fumie Mitani, Nejsum Peter Lindberg, Pociot Flemming, Yarani Reza | translational type 1 diabetes research, department of clinical and translational research, steno diabetes center copenhagen, herlev, denmark., translational type 1 diabetes research, department of clinical and translational research, steno diabetes center copenhagen, herlev, denmark., translational type 1 diabetes research, department of clinical and translational research, steno diabetes center copenhagen, herlev, denmark., department of clinical medicine, aarhus university, aarhus, denmark., translational type 1 diabetes research, department of clinical and translational research, steno diabetes center copenhagen, herlev, denmark., translational type 1 diabetes research, department of clinical and translational research, steno diabetes center copenhagen, herlev, denmark. | bioactive materials | bioact mater | 2452-199X | 18.0 | 18.2 | MATERIALS SCIENCE, BIOMATERIALS|Q1|1/53 | department of clinical and translational research, steno diabetes center copenhagen, department of clinical and translational research, steno diabetes center copenhagen, department of clinical and translational research, steno diabetes center copenhagen, department of clinical medicine, aarhus university, department of clinical and translational research, steno diabetes center copenhagen, department of clinical and translational research, steno diabetes center copenhagen | Unknown | aarhus university | 109 | 59.0 | 109.0 | Medium (50-75) | |
| 17 | 16 | assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review. | we conducted a review of topical medications available for alleviation of diabetic neuropathic pain (dnp) and compared their efficacy with oral medications for pain relief. we also explored the feasibility of compounding topical medications. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Elbeddini Ali, Tanvir Azasma, Yilmaz Orhan, Rahman Yusra, Mongon Renata | family medicine department, university of ottawa, school of medicine, 600 peter morand crescent suite 201, ottawa, on k1g 5z3 canada., college of medicine, university of saskatchewan, 107 wiggins rd, saskatoon, sk s7n 5e5 canada., college of medicine, university of saskatchewan, 107 wiggins rd, saskatoon, sk s7n 5e5 canada., faculty of health sciences, mcmaster university, 1280 main street west, hamilton, on l8s 4l8 canada., anesthesiology department, state university of campinas, campinas, brazil. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | university of ottawa, school of medicine, college of medicine, university of saskatchewan, college of medicine, university of saskatchewan, faculty of health sciences, mcmaster university, state university of campinas | Unknown | mcmaster university | 103 | 51.3 | 103.0 | Medium (50-75) | |
| 18 | 17 | material needs security and mental health outcomes in adults with type 2 diabetes in lebanon: a cross-sectional study. | despite their documented significance in type 2 diabetes (t2dm) management, social determinants of health (sdohs) including material needs security and mental health outcomes are understudied in the middle east and north africa (mena) region. this study aims to assess the relation between material needs security and mental health outcomes in lebanese adults with t2dm. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Sukkarieh Ola, Bassil Maya, Egede Leonard E | rafic hariri school of nursing, american university of beirut, beirut, lebanon., human nutrition department, college of health sciences, qu health, qatar university, p.o. box 2713, doha, qatar., department of medicine, university at buffalo, jacobs school of medicine and biomedical sciences, buffalo, ny usa. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | american university of beirut, college of health sciences, qu health, qatar university, university at buffalo, jacobs school of medicine and biomedical sciences | Unknown | american university | 601–800 | 17.1 | 700.5 | Low (0-50) | |
| 19 | 18 | the impact of substituting clarified butter with canola oil on the components of metabolic syndrome, fatty liver index, and insulin resistance among individuals diagnosed with metabolic syndrome: a quasi-experimental study. | clarified butter, contain harmful saturated and beneficial trans-fatty acids. canola oil is a promising alternative to other oils for reducing saturated fat intake. this trial aimed to investigate the effects of replacing clarified butter with canola oil in patients with metabolic syndrome on various metabolic syndrome components, fatty liver index (fli), and insulin resistance. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Sedgi Fatemeh Maleki, Hosseiniazar Mohammadreza Mohammad, Alizadeh Mohammad | student research committee, urmia university of medical sciences, urmia, iran., department of internal medicine, school of medicine, urmia university of medical sciences, urmia, iran., department of nutrition, school of medicine, urmia university of medical sciences, urmia, iran. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | urmia university of medical sciences, department of internal medicine, school of medicine, urmia university of medical sciences, department of nutrition, school of medicine, urmia university of medical sciences | trial | urmia university | 801–1000 | 19.5 | 900.5 | Low (0-50) | |
| 20 | 19 | correction: association between type 2 diabetes and branched chain amino acids (bcaa); a case-control study. | [this corrects the article doi: 10.1007/s40200-023-01247-9.]. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Abbas Torki Saheb, Bahadori Effat, Aghakhaninejad Zohreh, Khalatbari Mohseni Golsa, Tajadod Shirin, Rajabi Harsini Asma, Azaryan Fatemeh, Saeedirad Zahra, Ali Askarpour Seyed, Mahmoudi Zahra, Khoshdooz Sara, Bahar Bojlul, Shafaei Hanieh, Alireza Mosavi Jarrahi Seyed, Doaei Saeid, Nazemi Samad, Gholamalizadeh Maryam | department of nutrition, faculty of nutrition sciences, shiraz university of medical sciences, shiraz, iran., department of nutrition, mashhad university of medical sciences, mashhad, iran., department of nutrition, faculty of public health, kerman university of medical sciences, kerman, iran., nutrition and metabolic diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, iran., department of nutrition, school of public health, international campus, iran university of medical sciences, tehran, iran., department of clinical nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran., department of physiology, school of medicine, zahedan university of medical sciences, zahedan, iran., department of clinical nutrition and dietetics, faculty of nutrition and food technology, shahid beheshti university of medical sciences, tehran, iran., division of food safety and hygiene, department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran., department of nutrition, science and research branch, islamic azad university, tehran, iran., guilan university of medical sciences, rasht, iran., nutrition sciences and applied food safety studies, research centre for global development, school of sport and health sciences, university of central lancashire, preston, uk., nursing and midwifery school, guilan university of medical sciences, rasht, iran., school of medicine, shahid beheshti university of medical sciences, tehran, iran., department of community nutrition, faculty of nutrition sciences and food technology, national nutrition and food technology research institute, shahid beheshti university of medical sciences, tehran, iran., cellular and molecular research center, department of physiology and pharmacology, sabzevar university of medical science, sabzevar, iran., cancer research center, shahid beheshti university of medical sciences, tehran, iran. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | shiraz university of medical sciences, mashhad university of medical sciences, kerman university of medical sciences, ahvaz jundishapur university of medical sciences, international campus, iran university of medical sciences, tehran university of medical sciences, zahedan university of medical sciences, shahid beheshti university of medical sciences, tehran university of medical sciences, islamic azad university, guilan university of medical sciences, university of central lancashire, guilan university of medical sciences, shahid beheshti university of medical sciences, shahid beheshti university of medical sciences, sabzevar university of medical science, shahid beheshti university of medical sciences | Unknown | shiraz university | 801–1000 | 24.6 | 900.5 | Low (0-50) | |
| 21 | 20 | assessment of fracture risk in diabetic patients. | patients with diabetes often experience reduced bone strength, resulting in a higher fracture risk. this decline and increased susceptibility stem from intricate interactions within the bone microstructure. however, current gold standard methods for assessing bone strength, such as bone mineral density, and widely-used fracture risk assessment tools do not accurately predict fracture risk in diabetic patients. therefore, it is crucial to incorporate additional indicators that evaluate bone quality and specific markers relevant to diabetes to enhance the accuracy of predictive models. moreover, the selection of appropriate algorithms for model construction is essential. this review aims to introduce indicators from both imaging examinations and laboratory indicators that hold significant value for inclusion in fracture risk prediction models for diabetic patients. additionally, this study provides an overview of the research progress in fracture risk prediction models for diabetic patients, serving as a valuable reference for clinical practice. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Wang Zhenpeng, Zhang Mei, Jia Dan | department of laboratory medicine, west china hospital, sichuan university, chengdu, china., department of laboratory medicine, west china hospital, sichuan university, chengdu, china., department of outpatient, west china hospital, sichuan university, chengdu, china. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | west china hospital, sichuan university, west china hospital, sichuan university, west china hospital, sichuan university | Unknown | sichuan university | 150 | 57.3 | 150.0 | Medium (50-75) | |
| 22 | 21 | the impact of diabetes on tight junctions in cardiomyopathy dysfunction. | diabetic cardiomyopathy is a condition characterized by ventricular dysfunction in diabetic patients that is not caused by other cardiac ailments. it is associated with factors such as left ventricular hypertrophy, metabolic disturbances, and oxidative stress. tight junctions, which form a barrier between cells, play a role in the vascular complications of diabetes. proteins such as claudins and occludens are important for the structure and function of tight junctions. zona occludens (zo) proteins are also involved in tight junctions and their expression may be affected by diabetes. the review discusses the impact of diabetes on the tight junctions and the role of zo proteins in diabetic cardiovascular dysfunction. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Chodari Leila, Fatehfar Sina, Ahmadi Mahan, Ghorbanzadeh Vajihe | neurophysiology research center, cellular and molecular medicine research institute, urmia university of medical sciences, urmia, iran., student research committee, urmia university of medical sciences, urmia, iran., medical campus of xi'an jiaotong university, xi'an, shaanxi china., cardiovascular research center, shahid rahimi hospital, lorestan university of medical sciences, khorramabad, iran. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | urmia university of medical sciences, urmia university of medical sciences, xi'an jiaotong university, shahid rahimi hospital, lorestan university of medical sciences | Unknown | urmia university | 801–1000 | 19.5 | 900.5 | Low (0-50) | |
| 23 | 22 | effects of the switch from dulaglutide to tirzepatide on glycemic control, body weight, and fatty liver: a retrospective study. | tirzepatide belongs to a new class of anti-diabetic agents that stimulate both glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors, resulting in a greater blood glucose-lowering effect and body weight reduction than glucagon-like peptide-1 analogs. however, data on the effects of switching from glucagon-like peptide-1 analogs to tirzepatide on the blood glucose level, body weight, and liver functions are unavailable. | journal of diabetes and metabolic disorders | eng | 2024 | Dec | Sawamura Toshitaka, Mizoguchi Ren, Ohmori Ai, Kometani Mitsuhiro, Yoneda Takashi, Karashima Shigehiro | division department of internal medicine, asanogawa general hospital, 83 kosakamachi, kanazawa, ishikawa 920-8621 japan., department of health promotion and medicine of the future, kanazawa university, 13-1 takaramachi, kanazawa, 920-8641 japan., division department of internal medicine, asanogawa general hospital, 83 kosakamachi, kanazawa, ishikawa 920-8621 japan., department of health promotion and medicine of the future, kanazawa university, 13-1 takaramachi, kanazawa, 920-8641 japan., department of health promotion and medicine of the future, kanazawa university, 13-1 takaramachi, kanazawa, 920-8641 japan., department of health promotion and medicine of the future, kanazawa university, 13-1 takaramachi, kanazawa, 920-8641 japan. | journal of diabetes and metabolic disorders | j diabetes metab dis | 2251-6581 | 1.8 | 2.4 | ENDOCRINOLOGY & METABOLISM|Q4|143/186 | asanogawa general hospital, department of health promotion and medicine of the future, kanazawa university, asanogawa general hospital, department of health promotion and medicine of the future, kanazawa university, department of health promotion and medicine of the future, kanazawa university, department of health promotion and medicine of the future, kanazawa university | Unknown | kanazawa university | 1001–1200 | 18.8 | 1100.5 | Low (0-50) | |
| 24 | 23 | modifiable risk factors for cognitive frailty in older chinese patients with diabetes: a systematic review and meta-analysis. | to perform a systematic review and meta-analysis clarifying potential modifiable risk factors for cognitive frailty in older chinese persons with diabetes. we conducted a comprehensive search across four english and four chinese databases, spanning from 1980 to may 2024. the aim was to identify studies that investigate potential modifiable risk factors for cognitive frailty in older patients with diabetes. meta-analysis was performed using stata16.0. out of the 237 records identified, 19 studies met the inclusion criteria and were consequently included for analysis. the results of the meta-analysis revealed that the prevalence of cognitive frailty among older patients with diabetes was 22.2% (95% confidence interval [ci]: 0.177-0.270, i<sup>2</sup> = 93.92%). depression (or = 3.18, 95% ci: 2.19-4.62, i<sup>2</sup> = 79.6%), hba1c (or = 2.18, 95% ci: 1.66-2.85, i<sup>2</sup> = 41.5%) and malnutrition (or = 4.04, 95% ci: 1.58-10.34, i<sup>2</sup> = 95.0%) were significantly associated with cognitive frailty in this population. regular exercise (or = 0.30, 95% ci: 0.11-0.84, p < 0.01, i<sup>2</sup> = 87.3%) and higher education (or = 0.30, 95% ci: 0.16-0.58, p < 0.01, i<sup>2</sup> = 69.7%) are identified as protective factors against cognitive frailty. this systematic review and meta-analysis demonstrates that interventions targeting depression, hba1c level, malnutrition, exercise and education can effectively reduce the risk of cognitive frailty in older patients with diabetes. | research in nursing & health | eng | 2024 | Nov | Qiu Wenhui, Zhang Yixiong | department of nursing, nanjing university of chinese medicine, nanjing, jiangsu, china., department of nursing, nanjing university of chinese medicine, nanjing, jiangsu, china. | research in nursing & health | res nurs health | 0160-6891 | 1098-240X | 2.1 | 2.4 | NURSING|Q2|52/191 | nanjing university of chinese medicine, nanjing university of chinese medicine | Unknown | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) |
| 25 | 24 | gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: a perspective from the diabetes and pregnancy outcome for mother and baby study in japan. | to compare perinatal outcomes and postpartum glucose tolerance between women diagnosed with gestational diabetes mellitus (gdm) before 20 weeks of gestation (egdm) and those diagnosed at or after 24 weeks of gestation (lgdm) in a japanese population. | journal of diabetes investigation | eng | 2024 | Nov | Yokoyama Maki, Miyakoshi Kei, Iwama Noriyuki, Yamashita Hiroshi, Yasuhi Ichiro, Kawasaki Maki, Arata Naoko, Sato Shiori, Imura Yuko, Waguri Masako, Kawaguchi Haruna, Masaoka Naoki, Nakajima Yoshiyuki, Hiramatsu Yuji, Sugiyama Takashi | department of obstetrics and gynecology, ehime university graduate school of medicine, ehime, japan., department of obstetrics and gynecology, international catholic hospital, tokyo, japan., center for maternal and perinatal medicine, tohoku university hospital, miyagi, japan., department of obstetrics and gynecology, nho nagasaki medical center, nagasaki, japan., department of obstetrics and gynecology, nho nagasaki medical center, nagasaki, japan., department of women's health, national center for child health and development, tokyo, japan., department of women's health, national center for child health and development, tokyo, japan., department of women's health, national center for child health and development, tokyo, japan., department of women's health, national center for child health and development, tokyo, japan., department of obstetric medicine, osaka women's and children's hospital, osaka, japan., department of maternal-fetal medicine, osaka women's and children's hospital, osaka, japan., department of obstetrics and gynecology, tokyo women's medical university yachiyo medical center, yachiyo, chiba, japan., department of obstetrics and gynecology, tokyo women's medical university yachiyo medical center, yachiyo, chiba, japan., okayama city general medical center, okayama, japan., department of obstetrics and gynecology, ehime university graduate school of medicine, ehime, japan., No Affiliation | journal of diabetes investigation | j diabetes invest | 2040-1116 | 2040-1124 | 3.1 | 3.4 | ENDOCRINOLOGY & METABOLISM|Q2|85/186 | ehime university graduate school of medicine, department of obstetrics and gynecology, international catholic hospital, center for maternal and perinatal medicine, tohoku university hospital, department of obstetrics and gynecology, nho nagasaki medical center, nho nagasaki medical center, department of women's health, national center for child health and development, department of women's health, national center for child health and development, department of women's health, national center for child health and development, department of women's health, national center for child health and development, osaka women's and children's hospital, osaka women's and children's hospital, tokyo women's medical university, yachiyo medical center, tokyo women's medical university, yachiyo medical center, okayama city general medical center, ehime university graduate school of medicine | Unknown | ehime university | 1201–1500 | 14.9 | 1350.5 | Low (0-50) |
| 26 | 25 | association of uterine leiomyoma with type 2 diabetes mellitus in young women: a population-based cohort study (diabetes metab j 2024;48:1105-13). | no abstract | diabetes & metabolism journal | eng | 2024 | Nov | Qin Zhenzhi, Xu Yan | department of nephrology, the affiliated hospital of qingdao university, qingdao, china., department of nephrology, the affiliated hospital of qingdao university, qingdao, china. | diabetes & metabolism journal | diabetes metab j | 2233-6079 | 2233-6087 | 6.8 | 5.8 | ENDOCRINOLOGY & METABOLISM|Q1|18/186 | department of nephrology, qingdao university, department of nephrology, qingdao university | Unknown | qingdao university | 601–800 | 18.4 | 700.5 | Low (0-50) |
| 27 | 26 | cardiovascular disease & diabetes statistics in korea: nationwide data 2010 to 2019. | this study aimed to provide updated insights into the incidence and management of cardiovascular disease (cvd) in korean adults with diabetes. | diabetes & metabolism journal | eng | 2024 | Nov | Kim Jin Hwa, Lee Junyeop, Han Kyungdo, Kim Jae-Taek, Kwon Hyuk-Sang | department of endocrinology and metabolism, chosun university hospital, chosun university college of medicine, gwangju, korea., department of ophthalmology, asan medical center, university of ulsan college of medicine, seoul, korea., department of statistics and actuarial science, soongsil university, seoul, korea., department of internal medicine, chung-ang university hospital, chung-ang university college of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, yeouido st. mary's hospital, college of medicine, the catholic university of korea, seoul, korea., No Affiliation | diabetes & metabolism journal | diabetes metab j | 2233-6079 | 2233-6087 | 6.8 | 5.8 | ENDOCRINOLOGY & METABOLISM|Q1|18/186 | chosun university hospital, chosun university college of medicine, asan medical center, university of ulsan college of medicine, soongsil university, chung-ang university hospital, chung-ang university college of medicine, yeouido st. mary's hospital, the catholic university of korea | Unknown | chosun university | 1201–1500 | 20.8 | 1350.5 | Low (0-50) |
| 28 | 27 | metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus: a review and position statement of the fatty liver research group of the korean diabetes association. | since the role of the liver in metabolic dysfunction, including type 2 diabetes mellitus, was demonstrated, studies on non-alcoholic fatty liver disease (nafld) and metabolic dysfunction-associated fatty liver disease (mafld) have shown associations between fatty liver disease and other metabolic diseases. unlike the exclusionary diagnostic criteria of nafld, mafld diagnosis is based on the presence of metabolic dysregulation in fatty liver disease. renaming nafld as mafld also introduced simpler diagnostic criteria. in 2023, a new nomenclature, steatotic liver disease (sld), was proposed. similar to mafld, sld diagnosis is based on the presence of hepatic steatosis with at least one cardiometabolic dysfunction. sld is categorized into metabolic dysfunction-associated steatotic liver disease (masld), metabolic dysfunction and alcohol-related/-associated liver disease, alcoholrelated liver disease, specific etiology sld, and cryptogenic sld. the term masld has been adopted by a number of leading national and international societies due to its concise diagnostic criteria, exclusion of other concomitant liver diseases, and lack of stigmatizing terms. this article reviews the diagnostic criteria, clinical relevance, and differences among nafld, mafld, and masld from a diabetologist's perspective and provides a rationale for adopting sld/masld in the fatty liver research group of the korean diabetes association. | diabetes & metabolism journal | eng | 2024 | Nov | Bae Jaehyun, Han Eugene, Lee Hye Won, Park Cheol-Young, Chung Choon Hee, Lee Dae Ho, Cho Eun-Hee, Rhee Eun-Jung, Yu Ji Hee, Park Ji Hyun, Bae Ji-Cheol, Park Jung Hwan, Choi Kyung Mook, Kim Kyung-Soo, Seo Mi Hae, Lee Minyoung, Kim Nan-Hee, Kim So Hun, Lee Won-Young, Lee Woo Je, Choi Yeon-Kyung, Lee Yong-Ho, Hwang You-Cheol, Lyu Young Sang, Lee Byung-Wan, Cha Bong-Soo | division of endocrinology and metabolism, department of internal medicine, hallym university kangnam sacred heart hospital, college of medicine, hallym university, seoul, korea., division of endocrinology and metabolism, department of internal medicine, keimyung university school of medicine, daegu, korea., department of pathology, keimyung university school of medicine, daegu, korea., division of endocrinology and metabolism, department of internal medicine, kangbuk samsung hospital, sungkyunkwan university school of medicine, seoul, korea., department of internal medicine and research institute of metabolism and inflammation, yonsei university wonju college of medicine, wonju, korea., department of internal medicine, gachon university gil medical center, gachon university college of medicine, incheon, korea., department of internal medicine, kangwon national university hospital, kangwon national university school of medicine, chuncheon, korea., division of endocrinology and metabolism, department of internal medicine, kangbuk samsung hospital, sungkyunkwan university school of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, korea university college of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, jeonbuk national university hospital, jeonbuk national university medical school, jeonju, korea., division of endocrinology and metabolism, department of internal medicine, samsung changwon hospital, sungkyunkwan university school of medicine, changwon, korea., division of endocrinology & metabolism, department of internal medicine, hanyang university college of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, korea university college of medicine, seoul, korea., department of internal medicine, cha bundang medical center, cha university school of medicine, seongnam, korea., division of endocrinology and metabolism, department of internal medicine, soonchunhyang university gumi hospital, soonchunhyang university college of medicine, gumi, korea., division of endocrinology and metabolism, department of internal medicine, yonsei university college of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, korea university college of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, inha university college of medicine, incheon, korea., division of endocrinology and metabolism, department of internal medicine, kangbuk samsung hospital, sungkyunkwan university school of medicine, seoul, korea., department of internal medicine, asan medical center, university of ulsan college of medicine, seoul, korea., department of internal medicine, kyungpook national university chilgok hospital, school of medicine, kyungpook national university, daegu, korea., division of endocrinology and metabolism, department of internal medicine, yonsei university college of medicine, seoul, korea., division of endocrinology and metabolism, department of medicine, kyung hee university hospital at gangdong, college of medicine, kyung hee university, seoul, korea., division of endocrinology and metabolism, department of internal medicine, chosun university hospital, chosun university college of medicine, gwangju, korea., division of endocrinology and metabolism, department of internal medicine, yonsei university college of medicine, seoul, korea., division of endocrinology and metabolism, department of internal medicine, yonsei university college of medicine, seoul, korea., No Affiliation | diabetes & metabolism journal | diabetes metab j | 2233-6079 | 2233-6087 | 6.8 | 5.8 | ENDOCRINOLOGY & METABOLISM|Q1|18/186 | hallym university, hallym university, keimyung university school of medicine, keimyung university school of medicine, kangbuk samsung hospital, sungkyunkwan university school of medicine, yonsei university, wonju college of medicine, gachon university, gachon university college of medicine, kangwon national university, kangwon national university school of medicine, kangbuk samsung hospital, sungkyunkwan university school of medicine, korea university college of medicine, jeonbuk national university hospital, jeonbuk national university, sungkyunkwan university school of medicine, hanyang university college of medicine, korea university college of medicine, cha university school of medicine, soonchunhyang university, soonchunhyang university college of medicine, yonsei university college of medicine | Unknown | hallym university | 1201–1500 | 19.8 | 1350.5 | Low (0-50) |
| 29 | 28 | stronger association between morning serum cortisol level and diurnal time in range in type 2 diabetes? | the hypothalamic-pituitary-adrenal axis is thought to play a vital role in glucose homeostasis and diabetes. this study investigated the association between morning serum cortisol and time in range (tir), including daytime tir, in type 2 diabetes (t2dm). | diabetology & metabolic syndrome | eng | 2024 | Nov | Liang Yue, Liang Jingjing, Jiang Wenwen, Wang Wei, Yang Xinyi, Liu Yanyu, Jin Xuguang, Guo Qingyu, Xu Yixin, Lu Bin, Gu Ping, Shao Jiaqing | department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china., department of endocrinology, nanjing jinling hospital, nanjing, jiangsu, china., department of endocrinology, nanjing medical university, jinling hospital, nanjing, jiangsu, china., department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china., department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china., department of endocrinology, nanjing jinling hospital, nanjing, jiangsu, china., department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china., department of endocrinology, nanjing jinling hospital, nanjing, jiangsu, china., department of endocrinology, nanjing jinling hospital, nanjing, jiangsu, china., department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china. yearinyearout@126.com., department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china. guping@nju.edu.cn., department of endocrinology, nanjing jinling hospital, affiliated hospital of medical school, nanjing university, 305 east zhongshan road, nanjing, jiangsu, 210002, china. shaojiaq@hotmail.com. | diabetology & metabolic syndrome | diabetol metab syndr | 1758-5996 | 3.4 | 4.1 | ENDOCRINOLOGY & METABOLISM|Q2|72/186 | nanjing university, nanjing jinling hospital, nanjing medical university, nanjing university, nanjing university, nanjing jinling hospital, nanjing jinling hospital, nanjing university, nanjing jinling hospital, nanjing jinling hospital, nanjing jinling hospital, nanjing university, nanjing university, nanjing jinling hospital, nanjing university | Unknown | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) | |
| 30 | 29 | neck circumference, waist-to-height ratio, chinese visceral adiposity index and incident heart failure. | the indicators of abdominal obesity have shown to be associated with a high risk of cardiovascular diseases (cvds), even adjusted for body mass index (bmi). we aimed to investigate the association between neck circumference, waist-to-height ratio (whtr), chinese visceral adiposity index (cvai) and incident heart failure (hf) in chinese adults. | nutrition journal | eng | 2024 | Nov | Wu Zhijun, Huang Zhe, Sun Liang, Fu Yuang, Chen Shuohua, Wu Shouling, Gao Xiang | ruijin hospital, shanghai jiao tong university school of medicine, shanghai, people's republic of china., department of cardiology, kailuan general hospital, 57 xinhua east rd, tangshan, 063000, people's republic of china., department of nutrition and food hygiene, school of public health, institute of nutrition, fudan university, 130 dongan rd, shanghai, 200032, people's republic of china., department of nutrition and food hygiene, school of public health, institute of nutrition, fudan university, 130 dongan rd, shanghai, 200032, people's republic of china., department of cardiology, kailuan general hospital, 57 xinhua east rd, tangshan, 063000, people's republic of china., department of cardiology, kailuan general hospital, 57 xinhua east rd, tangshan, 063000, people's republic of china. drwusl@163.com., department of nutrition and food hygiene, school of public health, institute of nutrition, fudan university, 130 dongan rd, shanghai, 200032, people's republic of china. xiang_gao@fudan.edu.cn. | nutrition journal | nutr j | 1475-2891 | 4.4 | 4.6 | NUTRITION & DIETETICS|Q1|25/114 | people's republic of china, kailuan general hospital, people's republic of china, institute of nutrition, fudan university, people's republic of china, institute of nutrition, fudan university, people's republic of china, kailuan general hospital, people's republic of china, kailuan general hospital, people's republic of china, institute of nutrition, fudan university, people's republic of china | Unknown | fudan university | 44 | 75.3 | 44.0 | High (75-100) | |
| 31 | 30 | author correction: integration of whole-body [<sup>18</sup>f]fdg pet/mri with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes. | no abstract | scientific reports | eng | 2024 | Nov | Diamanti Klev, Visvanathar Robin, Pereira Maria J, Cavalli Marco, Pan Gang, Kumar Chanchal, Skrtic Stanko, Risérus Ulf, Eriksson Jan W, Kullberg Joel, Komorowski Jan, Wadelius Claes, Ahlström Håkan | science for life laboratory, department of cell and molecular biology, uppsala university, uppsala, sweden., department of surgical sciences, section of radiology, uppsala university, uppsala, sweden., department of medical sciences, clinical diabetes and metabolism, uppsala university, uppsala, sweden., science for life laboratory, department of immunology, genetics and pathology, uppsala university, uppsala, sweden., science for life laboratory, department of immunology, genetics and pathology, uppsala university, uppsala, sweden., translational science & experimental medicine, research and early development, cardiovascular, renal and metabolism (cvrm), biopharmaceuticals r&d, astrazeneca, gothenburg, sweden., pharmaceutical technology & development, astrazeneca ab, gothenburg, sweden., department of public health and caring sciences, clinical nutrition and metabolism, uppsala university, uppsala, sweden., department of medical sciences, clinical diabetes and metabolism, uppsala university, uppsala, sweden., department of surgical sciences, section of radiology, uppsala university, uppsala, sweden., science for life laboratory, department of cell and molecular biology, uppsala university, uppsala, sweden., science for life laboratory, department of immunology, genetics and pathology, uppsala university, uppsala, sweden., department of surgical sciences, section of radiology, uppsala university, uppsala, sweden. hakan.ahlstrom@radiol.uu.se. | scientific reports | sci rep-uk | 2045-2322 | 2045-2322 | 3.8 | 4.3 | MULTIDISCIPLINARY SCIENCES|Q1|25/134 | uppsala university, department of surgical sciences, uppsala university, uppsala university, uppsala university, uppsala university, uppsala university, uppsala university, department of surgical sciences, uppsala university, uppsala university, uppsala university, department of surgical sciences, uppsala university | Unknown | uppsala university | 140 | 55.0 | 140.0 | Medium (50-75) |
| 32 | 31 | impact of complete revascularization on long-term clinical outcomes in patients with multi-vessel disease, including chronic total occlusion. | to compare the long-term prognostic effect of complete percutaneous coronary intervention (pci) on cardiovascular events in chronic total occlusion (cto) patients with the multi-vessel disease (mvd) compared with medical therapy (mt). we enrolled 441 patients with cto and mvd who underwent pci. the study population was divided into the cto-pci (n = 231) and the cto-mt (n = 210) groups. active pci for non-cto lesions was permitted in both groups. the primary endpoint was defined as the composite of all-cause death or myocardial infarction (mi). the primary endpoint occurred more frequently in the cto-mt group (13.5%) than in the cto-pci group (4.7%; p = 0.002). however, the target vessel revascularization (tvr), as a secondary endpoint, occurred more in the cto-pci group (16.3% vs. 5.5%, p = 0.001). after propensity score matching (psm) analysis, the primary endpoint was higher in the cto-mt group (12.6%) than in the pci group (2.3%): all-cause death (8.4% vs. 2.3%, p = 0.042) and mi (4.3% vs. 0.0%, p = 0.023). moreover, tvr of the cto lesions occurred more frequently in the cto-pci group (18.1% vs. 6.8%, p = 0.009). significant improvement in the left ventricular ejection fraction (lvef) was observed in both groups. according to the results of the subgroup analysis, cto-pci may be more effective in patients with diabetes, preserved lvef (> 50%), and well-developed collateral vessels (> grade ii). in this study, complete revascularization in cto with mvd reduced the incidence of all-cause death, mi, and a composite of both over a 5 year follow-up compared to medical treatment for cto lesions. | heart and vessels | eng | 2024 | Nov | Yang Dong Ju, Park Soohyung, Rha Seung-Woon, Choi Se Yeon, Choi Cheol Ung, Choi Byoung Geol | department of cardiology, cheongju st. mary's hospital, cheongju, republic of korea., cardiovascular center, korea university guro hospital, 148, gurodong-ro, guro-gu, seoul, 08308, korea., cardiovascular center, korea university guro hospital, 148, gurodong-ro, guro-gu, seoul, 08308, korea. swrha617@yahoo.co.kr., cardiovascular research institute, korea university, 198, gamasan-ro, guro-gu, seoul, 08309, republic of korea., cardiovascular center, korea university guro hospital, 148, gurodong-ro, guro-gu, seoul, 08308, korea., cardiovascular research institute, korea university, 198, gamasan-ro, guro-gu, seoul, 08309, republic of korea. trv940@naver.ac.kr. | heart and vessels | heart vessels | 0910-8327 | 1615-2573 | 1.4 | 1.4 | PERIPHERAL VASCULAR DISEASE|Q3|72/96 | korea university, korea university, korea university, korea university, korea university | pci | korea university | 201–250 | 46.6 | 225.5 | Low (0-50) |
| 33 | 32 | decoding medina 0.0.1 bifurcation: are all codes equal? results from a multicentric registry. | this study aimed to detail the technical management of medina 0.0.1 lesions, assess their outcomes, and identify predictors of major adverse cardiovascular events (mace). | international journal of cardiology | eng | 2024 | Nov | Maurina Matteo, Riche Maya, Oliva Omar, Zendjebil Sandra, Laforgia Pietro, Garot Philippe, Hovasse Thomas, Unterseeh Thierry, Neylon Antoinette, Farah Bruno, Smits Pieter C, Louvard Yves, Honton Benjamin, Paradies Valeria, Sanguineti Francesca | department of biomedical sciences, humanitas university, milan, pieve emanuele, italy; cardio center, irccs humanitas research hospital, milan, rozzano, italy; department of cardiology, maasstad hospital, rotterdam, the netherlands., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., department of interventional cardiology, clinique pasteur, toulouse, france., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., department of interventional cardiology, clinique pasteur, toulouse, france., department of cardiology, maasstad hospital, rotterdam, the netherlands; department of cardiology, erasmus university medical center, thoraxcenter, rotterdam, the netherlands., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france., department of interventional cardiology, clinique pasteur, toulouse, france., department of cardiology, maasstad hospital, rotterdam, the netherlands; department of cardiology, erasmus university medical center, thoraxcenter, rotterdam, the netherlands., institut cardiovasculaire paris sud, ramsay générale de santé, massy, france. electronic address: f.sanguineti@angio-icps.com. | international journal of cardiology | int j cardiol | 0167-5273 | 1874-1754 | 3.2 | 3.2 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q2|62/220 | humanitas university, irccs humanitas research hospital, department of cardiology, maasstad hospital, department of interventional cardiology, department of interventional cardiology, department of cardiology, maasstad hospital, erasmus university medical center, department of interventional cardiology, department of cardiology, erasmus university medical center | Unknown | humanitas university | 251–300 | 27.9 | 275.5 | Low (0-50) |
| 34 | 33 | ph in the vertebrate retina and its naturally occurring and pathological changes. | this review summarizes the existing information on the concentration of h<sup>+</sup> (ph) in vertebrate retinae and its changes due to various reasons. special features of h<sup>+</sup> homeostasis that make it different from other ions will be discussed, particularly metabolic production of h<sup>+</sup> and buffering. the transretinal distribution of extracellular h<sup>+</sup> concentration ([h<sup>+</sup>]<sub>o</sub>) and its changes under illumination and other conditions will be described in detail, since [h<sup>+</sup>]<sub>o</sub> is more intensively investigated than intracellular ph. in vertebrate retinae, the highest [h<sup>+</sup>]<sub>o</sub> occurs in the inner part of the outer nuclear layer, and decreases toward the rpe, reaching the blood level on the apical side of the rpe. [h<sup>+</sup>]<sub>o</sub> falls toward the vitreous as well, but less, so that the inner retina is acidic to the vitreous. light leads to complex changes with both electrogenic and metabolic origins, culminating in alkalinization. there is a rhythm of [h<sup>+</sup>]<sub>o</sub> with h<sup>+</sup> being higher during circadian night. extracellular ph can potentially be used as a signal in intercellular volume transmission, but evidence is against ph as a normal controller of fluid transport across the rpe or as a horizontal cell feedback signal. pathological and experimentally created conditions (systemic metabolic acidosis, hypoxia and ischemia, vascular occlusion, excess glucose and diabetes, genetic disorders, and blockade of carbonic anhydrase) disturb h<sup>+</sup> homeostasis, mostly producing retinal acidosis, with consequences for retinal blood flow, metabolism and function. | progress in retinal and eye research | eng | 2024 | Nov | Dmitriev Andrey V, Linsenmeier Robert A | department of biomedical engineering, northwestern university, evanston, il. electronic address: anvadmi@gmail.com., department of biomedical engineering, northwestern university, evanston, il; department of neurobiology, northwestern university, evanston, il; department of ophthalmology, northwestern university, chicago, il. electronic address: r-linsenmeier@northwestern.edu. | progress in retinal and eye research | prog retin eye res | 1350-9462 | 1873-1635 | 18.6 | 20.3 | OPHTHALMOLOGY|Q1|1/95 | northwestern university, department of biomedical engineering, northwestern university, northwestern university, northwestern university | Unknown | northwestern university | 28 | 78.8 | 28.0 | High (75-100) |
| 35 | 34 | risks of major arterial and venous thrombotic diseases after hospitalisation for influenza, pneumonia, and covid-19: a population-wide cohort in 2.6 million people in wales. | pneumonia, influenza, covid-19, and other common infections might increase the risk of thrombotic events acutely through an interaction between inflammation and the thrombotic system. the long-term risks of arterial and venous thrombotic events following hospitalisation for covid-19 and hospitalisation for pneumonia or influenza are unclear. | thrombosis research | eng | 2024 | Nov | Keene Spencer, Abbasizanjani Hoda, Torabi Fatemeh, Knight Rochelle, Walker Venexia, Raffetti Elena, Cezard Genevieve, Ip Samantha, Sampri Alexia, Bolton Thomas, Denholm Rachel, Khunti Kamlesh, Akbari Ashley, Quint Jennifer, Denaxas Spiros, Sudlow Cathie, Di Angelantonio Emanuele, Sterne Jonathan A C, Wood Angela, Whiteley William N | british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk; nihr blood and transplant research unit in donor health and behaviour, university of cambridge, cambridge, uk. electronic address: sjk98@cam.ac.uk., population data science, swansea university medical school, faculty of medicine, health, and life science, swansea university, swansea, uk., population data science, swansea university medical school, faculty of medicine, health, and life science, swansea university, swansea, uk., department of population health sciences, bristol medical school, university of bristol, bristol, uk; mrc integrative epidemiology unit, bristol, uk; nihr applied research collaboration west, bristol, uk; nihr bristol biomedical research centre, bristol, uk., department of population health sciences, bristol medical school, university of bristol, bristol, uk; mrc integrative epidemiology unit, bristol, uk; department of surgery, university of pennsylvania perelman school of medicine, philadelphia, pennsylvania, usa., british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk; department of global public health, karolinska institutet, stockholm, sweden., british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk., british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk; centre for cancer genetic epidemiology, department of public health and primary care, university of cambridge, cambridge, uk; cambridge centre for ai in medicine, uk., british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk., british heart foundation data science centre, health data research uk, london, uk., department of population health sciences, bristol medical school, university of bristol, bristol, uk; nihr bristol biomedical research centre, bristol, uk; health data research uk south-west, bristol, uk., diabetes research centre, university of leicester, uk., population data science, swansea university medical school, faculty of medicine, health, and life science, swansea university, swansea, uk., school of public health, imperial college london, london, w12 0bz, united kingdom., british heart foundation data science centre, health data research uk, london, uk; institute of health informatics, university college london; university college london, hospitals biomedical research centre, university college london, uk., british heart foundation data science centre, health data research uk, london, uk., british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk; nihr blood and transplant research unit in donor health and behaviour, university of cambridge, cambridge, uk; british heart foundation centre of research excellence, university of cambridge, cambridge, uk; health data research uk cambridge, wellcome genome campus and university of cambridge, hinxton, uk; health data science centre, human technopole, milan, italy., department of population health sciences, bristol medical school, university of bristol, bristol, uk; nihr bristol biomedical research centre, bristol, uk; health data research uk south-west, bristol, uk., british heart foundation cardiovascular epidemiology unit, department of public health and primary care, university of cambridge, cambridge, uk; victor phillip dahdaleh heart and lung research institute, university of cambridge, cambridge, uk; nihr blood and transplant research unit in donor health and behaviour, university of cambridge, cambridge, uk; british heart foundation data science centre, health data research uk, london, uk; british heart foundation centre of research excellence, university of cambridge, cambridge, uk; health data research uk cambridge, wellcome genome campus and university of cambridge, hinxton, uk; nihr cambridge biomedical research centre, uk; cambridge centre for ai in medicine, uk., british heart foundation data science centre, health data research uk, london, uk; centre for clinical brain sciences, university of edinburgh, uk., No Affiliation | thrombosis research | thromb res | 0049-3848 | 1879-2472 | 3.7 | 4.1 | PERIPHERAL VASCULAR DISEASE|Q1|21/96 | british heart foundation, university of cambridge, university of cambridge, university of cambridge, swansea university, swansea university, swansea university, swansea university, bristol medical school, university of bristol, bristol medical school, university of bristol, university of pennsylvania, british heart foundation, university of cambridge, university of cambridge, karolinska institutet, british heart foundation, university of cambridge, university of cambridge, british heart foundation, university of cambridge, university of cambridge, university of cambridge | Unknown | swansea university | 251–300 | 30.2 | 275.5 | Low (0-50) |
| 36 | 35 | fgf21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery. | this research investigates the determinants of circulating fgf21 levels in a cohort reflecting metabolic disease progression, examining the associations of circulating fgf21 with morphology and function of adipose tissue (at), and with metabolic adjustments following metabolic surgery. | ebiomedicine | eng | 2024 | Nov | Patt Marie, Karkossa Isabel, Krieg Laura, Massier Lucas, Makki Kassem, Tabei Shirin, Karlas Thomas, Dietrich Arne, Gericke Martin, Stumvoll Michael, Blüher Matthias, von Bergen Martin, Schubert Kristin, Kovacs Peter, Chakaroun Rima M | university of leipzig medical centre, medical department iii-endocrinology, nephrology, rheumatology, leipzig, germany., department of molecular systems biology, helmholtz-centre for environmental research - ufz, leipzig, germany., department of molecular systems biology, helmholtz-centre for environmental research - ufz, leipzig, germany., university of leipzig medical centre, medical department iii-endocrinology, nephrology, rheumatology, leipzig, germany; department of medicine (h7), karolinska institutet, stockholm, sweden., inserm u1060, inrae umr1397, université de lyon, france., institute of endocrinology and diabetes, university of lübeck, lübeck, germany; centre of brain, behaviour, and metabolism (cbbm), university of lübeck, lübeck, germany., division of gastroenterology, medical department ii, university of leipzig medical centre, leipzig, germany., department of visceral, transplant, thoracic and vascular surgery, university of leipzig medical centre, leipzig, germany., leipzig university, institute of anatomy, leipzig, germany., university of leipzig medical centre, medical department iii-endocrinology, nephrology, rheumatology, leipzig, germany; helmholtz institute for metabolic obesity and vascular research (hi-mag), helmholtz zentrum münchen, university of leipzig and university hospital leipzig, leipzig, germany., university of leipzig medical centre, medical department iii-endocrinology, nephrology, rheumatology, leipzig, germany; helmholtz institute for metabolic obesity and vascular research (hi-mag), helmholtz zentrum münchen, university of leipzig and university hospital leipzig, leipzig, germany., department of molecular systems biology, helmholtz-centre for environmental research - ufz, leipzig, germany; institute of biochemistry, leipzig university, leipzig, germany; german centre for integrative biodiversity research (idiv) halle-jena-leipzig, leipzig, germany., department of molecular systems biology, helmholtz-centre for environmental research - ufz, leipzig, germany., university of leipzig medical centre, medical department iii-endocrinology, nephrology, rheumatology, leipzig, germany; deutsches zentrum für diabetesforschung e.v., 85764, neuherberg, germany., university of leipzig medical centre, medical department iii-endocrinology, nephrology, rheumatology, leipzig, germany; wallenberg laboratory, department of molecular and clinical medicine and sahlgrenska centre for cardiovascular and metabolic research, university of gothenburg, gothenburg, sweden. electronic address: rima.chakaroun@wlab.gu.se. | ebiomedicine | ebiomedicine | 2352-3964 | 2352-3964 | 9.7 | 9.2 | MEDICINE, RESEARCH & EXPERIMENTAL|Q1|12/189 | university of leipzig medical centre, helmholtz-centre for environmental research - ufz, helmholtz-centre for environmental research - ufz, university of leipzig medical centre, karolinska institutet, université de lyon, university of lübeck, university of lübeck, university of leipzig medical centre, university of leipzig medical centre, leipzig university, university of leipzig medical centre, helmholtz institute for metabolic obesity and vascular research, helmholtz zentrum münchen, university of leipzig, university hospital leipzig, university of leipzig medical centre, helmholtz zentrum münchen, university of leipzig, university hospital leipzig, helmholtz-centre for environmental research - ufz, leipzig university, helmholtz-centre for environmental research - ufz, university of leipzig medical centre, deutsches zentrum für diabetesforschung e.v., university of leipzig medical centre | Unknown | karolinska institute | 50 | 67.9 | 50.0 | Medium (50-75) |
| 37 | 36 | hyperammonaemic encephalopathy due to non-functioning urea cycle as a complication to gastric bypass surgery. | hyperammonaemic encephalopathy in the absence of liver failure is a major diagnostic challenge. a rare cause is as a complication to previous gastric bypass surgery, a condition reported to be associated with high mortality. in this case report, we present the exhaustive diagnostic work-up and clinical reversal of deep and recurrent hyperammonaemic encephalopathy in a patient with previous gastric bypass surgery. as a key finding, the patient exhibited an extreme reduction of the in vivo capacity for urea synthesis, which was reverted by long-standing correction of severe protein and micronutrient malnourishment (functional hepatic nitrogen clearance; 2.9 to 25.5 l/h). in addition, we observed reduced levels of fasting plasma amino acids (α-amino nitrogen; 2.7 to 3.6 mmol/l) and glucagon (0.3 to 2.6 pmol/l) before clinical improvement, which may contribute to the non-functioning urea synthesis. these observations elucidate the underlying pathophysiology of hyperammonaemia as a complication of gastric bypass and highlight a potential mechanism - non-functioning urea cycle as a result of protein malnourishment and hepatic glucagon resistance. | metabolic brain disease | eng | 2024 | Nov | Kjærgaard Kristoffer, Eriksen Peter Lykke, Nøhr Thomas Kromann, Pedersen Steen Bønløkke, Gravholt Claus Højbjerg, Vilstrup Hendrik, Thomsen Karen Louise | department of hepatology and gastroenterology, aarhus university hospital, palle juul-jensens boulevard, aarhus, denmark. krikje@clin.au.dk., department of hepatology and gastroenterology, aarhus university hospital, palle juul-jensens boulevard, aarhus, denmark., department of hepatology and gastroenterology, aarhus university hospital, palle juul-jensens boulevard, aarhus, denmark., department of clinical medicine, aarhus university, aarhus, denmark., department of clinical medicine, aarhus university, aarhus, denmark., department of hepatology and gastroenterology, aarhus university hospital, palle juul-jensens boulevard, aarhus, denmark., department of hepatology and gastroenterology, aarhus university hospital, palle juul-jensens boulevard, aarhus, denmark. | metabolic brain disease | metab brain dis | 0885-7490 | 1573-7365 | 3.2 | 3.3 | NEUROSCIENCES|Q2|128/310 | department of hepatology and gastroenterology, aarhus university hospital, department of hepatology and gastroenterology, aarhus university hospital, department of hepatology and gastroenterology, aarhus university hospital, department of clinical medicine, aarhus university, aarhus university, department of hepatology and gastroenterology, aarhus university hospital, department of hepatology and gastroenterology, aarhus university hospital | Unknown | aarhus university | 109 | 59.0 | 109.0 | Medium (50-75) |
| 38 | 37 | metabolic stress in patients with acute severe ulcerative colitis - a single-center cohort study. | acute severe ulcerative colitis (asuc) is characterized by systemic inflammation, which may initiate an acute-phase response leading to hypercatabolism. patients with asuc are usually treated with high-dose steroids that may further accelerate the metabolic response and lead to hyperglycemia and insulin resistance. nevertheless, the degree of synergy between inflammation and steroid treatment and their influence on the insulin resistance remains unknown. we aimed to measure the degree of metabolic stress including insulin resistance in patients with asuc during admission and three weeks after discharge. | frontiers in endocrinology | eng | 2024 | No Data | Redsted Mathias, Grønhøj Magnus, Brøchner Louise Dalsgaard, Fassov Janne, Svart Mads Vandsted, Andersen Jens Rikardt, Hvas Christian Lodberg | department of nutrition, exercise and sports, university of copenhagen, copenhagen, denmark., department of nutrition, exercise and sports, university of copenhagen, copenhagen, denmark., department of nutrition, exercise and sports, university of copenhagen, copenhagen, denmark., department of hepatology and gastroenterology, aarhus university hospital, aarhus, denmark., steno diabetes center aarhus, aarhus university hospital, aarhus, denmark., department of nutrition, exercise and sports, university of copenhagen, copenhagen, denmark., department of hepatology and gastroenterology, aarhus university hospital, aarhus, denmark. | frontiers in endocrinology | front endocrinol | 1664-2392 | 1664-2392 | 3.9 | 4.9 | ENDOCRINOLOGY & METABOLISM|Q2|51/186 | university of copenhagen, university of copenhagen, university of copenhagen, department of hepatology and gastroenterology, aarhus university hospital, aarhus university hospital, university of copenhagen, department of hepatology and gastroenterology, aarhus university hospital | Unknown | aarhus university | 109 | 59.0 | 109.0 | Medium (50-75) |
| 39 | 38 | glucagon-like peptide-1 receptor agonists and the risk of erectile dysfunction: a drug target mendelian randomization study. | glucagon-like peptide-1 receptor agonists (glp-1ras) have been widely used for type 2 diabetes (t2d) and weight management. however, the causal relationship of glp-1ras with erectile dysfunction (ed) was still unclear. | frontiers in endocrinology | eng | 2024 | No Data | An Hongjin, Xie Kexin, Gan Huatian | department of gastroenterology and hepatology, west china hospital, sichuan university, chengdu, china., department of gastroenterology and hepatology, west china hospital, sichuan university, chengdu, china., department of geriatrics and national clinical research center for geriatrics, west china hospital, sichuan university, chengdu, china. | frontiers in endocrinology | front endocrinol | 1664-2392 | 1664-2392 | 3.9 | 4.9 | ENDOCRINOLOGY & METABOLISM|Q2|51/186 | department of gastroenterology and hepatology, west china hospital, sichuan university, department of gastroenterology and hepatology, west china hospital, sichuan university, department of geriatrics and national clinical research center for geriatrics, west china hospital, sichuan university | weight management | sichuan university | 150 | 57.3 | 150.0 | Medium (50-75) |
| 40 | 39 | editorial: insights in obesity: 2023. | no abstract | frontiers in endocrinology | eng | 2024 | No Data | Nonogaki Katsunori | division of diabetes and nutrition, raris, tohoku university, sendai, miyagi, japan. | frontiers in endocrinology | front endocrinol | 1664-2392 | 1664-2392 | 3.9 | 4.9 | ENDOCRINOLOGY & METABOLISM|Q2|51/186 | raris, tohoku university | Unknown | tohoku university | 130 | 66.4 | 130.0 | Medium (50-75) |
| 41 | 40 | one-year risk prediction of elevated serum uric acid levels in older adults: a longitudinal cohort study. | to develop and externally validate a nomogram to predict elevated serum uric acid (sua) levels in older adults. | clinical interventions in aging | eng | 2024 | No Data | Zhang Dexian, Xu Xinxin, Ye Zhibin, Zhang Zhenxing, Xiao Jing | department of nephrology, huadong hospital, fudan university, shanghai, people's republic of china., shanghai key laboratory of clinical geriatric medicine, huadong hospital, fudan university, shanghai, people's republic of china., department of nephrology, huadong hospital, fudan university, shanghai, people's republic of china., department of nephrology, huadong hospital, fudan university, shanghai, people's republic of china., department of nephrology, huadong hospital, fudan university, shanghai, people's republic of china. | clinical interventions in aging | clin interv aging | 1178-1998 | 3.5 | 4.5 | GERIATRICS & GERONTOLOGY|Q2|29/74 | fudan university, people's republic of china, fudan university, people's republic of china, fudan university, people's republic of china, fudan university, people's republic of china, fudan university, people's republic of china | Unknown | fudan university | 44 | 75.3 | 44.0 | High (75-100) | |
| 42 | 41 | the interaction between triglyceride-glucose index and visceral adiposity in cardiovascular disease risk: findings from a nationwide chinese cohort. | globally, cardiovascular disease (cvd) constitutes the primary cause of death, with insulin resistance (ir), measured by the triglyceride-glucose (tyg) index, and visceral obesity, reflected by the chinese visceral adiposity index (cvai), as key contributors. however, the relationship between the tyg index and cvai regarding cvd risk remains insufficiently understood. this research investigates the interactive impact of the tyg index and cvai on the risk of cardiovascular disease. | cardiovascular diabetology | eng | 2024 | Nov | Yang Yuhao, Li Shengxi, Ren Qiao, Qiu Yu, Pan Mengjia, Liu Guanglei, Zheng Rise, An Zhenmei, Li Shuangqing | general practice ward/international medical center ward, general practice medical center, west china hospital, sichuan university, chengdu, china., clinical medical college, southwest medical university, luzhou, china., department of endocrinology and metabolism, west china hospital, sichuan university, chengdu, china., general practice ward/international medical center ward, general practice medical center, west china hospital, sichuan university, chengdu, china., general practice ward/international medical center ward, general practice medical center, west china hospital, sichuan university, chengdu, china., department of endocrinology and metabolism, west china hospital, sichuan university, chengdu, china., general practice ward/international medical center ward, general practice medical center, west china hospital, sichuan university, chengdu, china., department of endocrinology and metabolism, west china hospital, sichuan university, chengdu, china., general practice ward/international medical center ward, general practice medical center, west china hospital, sichuan university, chengdu, china. 1259594471@qq.com. | cardiovascular diabetology | cardiovasc diabetol | 1475-2840 | 8.5 | 8.9 | ENDOCRINOLOGY & METABOLISM|Q1|11/186 | west china hospital, sichuan university, clinical medical college, southwest medical university, department of endocrinology and metabolism, west china hospital, sichuan university, west china hospital, sichuan university, west china hospital, sichuan university, department of endocrinology and metabolism, west china hospital, sichuan university, west china hospital, sichuan university, department of endocrinology and metabolism, west china hospital, sichuan university, west china hospital, sichuan university | Unknown | sichuan university | 150 | 57.3 | 150.0 | Medium (50-75) | |
| 43 | 42 | relationship between stroke and estimated glucose disposal rate: results from two prospective cohort studies. | insulin resistance (ir) is a recognized contributor to stroke association, and the estimated glucose disposal rate (egdr) is a dependable indicator of ir. however, the specific connections between egdr, stroke prevalence, and overall mortality have not been thoroughly investigated. this study aimed to examine how egdr correlates with stroke and overall death rate. | lipids in health and disease | eng | 2024 | Nov | Han Yutong, Zhang Kexin, Luo Yue, Wan Bin, Zhang Yaowen, Huang Qinchuan, Liu Hanyu, Leng Yulin, Xie Chunguang | chengdu university of traditional chinese medicine, no. 37 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., southwest medical university, no.319 zhongshan road, luzhou, sichuan province, 646000, people's republic of china., chengdu university of traditional chinese medicine, no. 37 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., chengdu university of traditional chinese medicine, no. 37 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., chengdu university of traditional chinese medicine, no. 37 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., chengdu university of traditional chinese medicine, no. 37 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., chengdu university of traditional chinese medicine, no. 37 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., hospital of chengdu university of traditional chinese medicine, no. 39 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china., hospital of chengdu university of traditional chinese medicine, no. 39 shi-er-qiao road, chengdu, sichuan province, 610072, people's republic of china. xiecg@cdutcm.edu.cn. | lipids in health and disease | lipids health dis | 1476-511X | 3.9 | 4.3 | NUTRITION & DIETETICS|Q2|32/114 | chengdu university of traditional chinese medicine, people's republic of china, southwest medical university, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china, chengdu university of traditional chinese medicine, people's republic of china | Unknown | chengdu university | 801–1000 | 14.5 | 900.5 | Low (0-50) | |
| 44 | 43 | optimising the treatment of chronic ischemic heart disease by training general practitioners to deliver very brief advice on physical activity (opticor): protocol of the systematic development and evaluation of a complex intervention. | chronic ischemic heart disease (ihd) is one of the leading causes of morbidity and mortality. physical activity (pa) is an effective secondary preventive strategy in ihd management. the german treatment guideline recommends that general practitioners (gps) deliver pa advice to patients. this recommendation seems inadequately implemented, often due to gp's insufficient specific training. international guidelines recommend training gps in how to deliver such advice effectively and efficiently. evidence is lacking on whether such training can enhance the frequency and quality of pa advice in routine care. the opticor project aims to develop and evaluate a gp training in the delivery of very brief pa advice to optimise the treatment of patients with ihd in general practice. | bmc primary care | eng | 2024 | Nov | Hoppe Sabrina, Prinz Alicia, Crutzen Rik, Donner-Banzhoff Norbert, Icks Andrea, Kotz Daniel, Kuß Oliver, Mons Ute, Vomhof Markus, Wilm Stefan, Kastaun Sabrina | institute of general practice (ifam), patient-physician-communication research unit, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute of general practice (ifam), patient-physician-communication research unit, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., department of health promotion, care and public health research institute (caphri), maastricht university, maastricht, the netherlands., institute of general practice, philipps-university marburg, marburg, germany., institute for health services research and health economics, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute of general practice (ifam), addiction research and clinical epidemiology unit, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute for biometrics and epidemiology, german diabetes center, leibniz center for diabetes research at heinrich-heine-university düsseldorf, düsseldorf, germany., department of cardiology, faculty of medicine and university hospital cologne, university of cologne, cologne, germany., institute for health services research and health economics, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute of general practice (ifam), patient-physician-communication research unit, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute of general practice (ifam), patient-physician-communication research unit, centre for health and society (chs), medical faculty and university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany. sabrina.kastaun@med.uni-duesseldorf.de. | bmc primary care | bmc prim care | 2731-4553 | 2.0 | 2.0 | PRIMARY HEALTH CARE|Q2|15/30 | institute of general practice (ifam), centre for health and society (chs), medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, institute of general practice (ifam), centre for health and society (chs), medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, maastricht university, institute of general practice, philipps-university marburg, institute for health services research and health economics, centre for health and society (chs), medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, institute of general practice (ifam), centre for health and society (chs), medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, institute for biometrics and epidemiology, heinrich-heine-university düsseldorf, university hospital cologne, university of cologne, institute for health services research and health economics, centre for health and society (chs), university hospital düsseldorf, heinrich-heine-university düsseldorf, institute of general practice (ifam), centre for health and society (chs), medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, institute of general practice (ifam), centre for health and society (chs), medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf | opticor project | maastricht university | 138 | 47.1 | 138.0 | Low (0-50) | |
| 45 | 44 | fungal symbiont transmitted by free-living mice promotes type 2 immunity. | the gut mycobiota is crucial for intestinal homeostasis and immune function<sup>1</sup>. yet its variability and inconsistent fungal colonization of laboratory mice hinders the study of the evolutionary and immune processes that underpin commensalism<sup>2,3</sup>. here, we show that kazachstania pintolopesii is a fungal commensal in wild urban and rural mice, with an exceptional ability to colonize the mouse gastrointestinal tract and dominate the gut mycobiome. kazachstania pintolopesii colonization occurs in a bacteria-independent manner, results in enhanced colonization resistance to other fungi and is shielded from host immune surveillance, allowing commensal presence. following changes in the mucosal environment, k. pintolopesii colonization triggers a type 2 immune response in mice and induces gastrointestinal eosinophilia. mechanistically, we determined that k. pintolopesii activates type 2 immunity via the induction of epithelial il-33 and downstream il-33-st2 signalling during mucus fluctuations. kazachstania pintolopesii-induced type 2 immunity enhanced resistance to helminth infections or aggravated gastrointestinal allergy in a context-dependent manner. our findings indicate that k. pintolopesii is a mouse commensal and serves as a valuable model organism for studying gut fungal commensalism and immunity in its native host. its unnoticed presence in mouse facilities highlights the need to evaluate its influence on experimental outcomes and phenotypes. | nature | eng | 2024 | Nov | Liao Yun, Gao Iris H, Kusakabe Takato, Lin Woan-Yu, Grier Alexander, Pan Xiangyu, Morzhanaeva Olga, Shea Terrance P, Yano Hiroshi, Karo-Atar Danielle, Olsen Kaitlin A, Oh Ji Hoon, Vandegrift Kurt J, King Irah L, Cuomo Christina A, Artis David, Rehermann Barbara, Lipman Neil, Iliev Iliyan D | joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., infectious disease and microbiome program, broad institute of mit and harvard, cambridge, ma, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., department of microbiology and immunology, meakins-christie laboratories, research institute of the mcgill university health centre, montreal, quebec, canada., department of microbiology and immunology, meakins-christie laboratories, research institute of the mcgill university health centre, montreal, quebec, canada., immunology section, liver diseases branch, national institute of diabetes and digestive and kidney diseases, national institutes of health, dhhs, bethesda, md, usa., department of biology, the pennsylvania state university, university park, pa, usa., department of microbiology and immunology, meakins-christie laboratories, research institute of the mcgill university health centre, montreal, quebec, canada., infectious disease and microbiome program, broad institute of mit and harvard, cambridge, ma, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa., immunology section, liver diseases branch, national institute of diabetes and digestive and kidney diseases, national institutes of health, dhhs, bethesda, md, usa., center for comparative medicine and pathology, memorial sloan kettering cancer center and weill cornell medicine, new york, ny, usa., joan and sanford i. weill department of medicine, weill cornell medicine, cornell university, new york, ny, usa. idi@ilievlab.org. | nature | nature | 0028-0836 | 1476-4687 | 50.5 | 54.4 | MULTIDISCIPLINARY SCIENCES|Q1|1/134 | cornell university, cornell university, cornell university, cornell university, cornell university, cornell university, cornell university, broad institute of mit and harvard, cornell university, mcgill university health centre, mcgill university, national institute of diabetes and digestive and kidney diseases, national institutes of health, dhhs, the pennsylvania state university, mcgill university, broad institute of mit and harvard, cornell university | Unknown | cornell university | 20 | 88.7 | 20.0 | High (75-100) |
| 46 | 45 | vasculogenic skin reprogramming requires tet-mediated gene demethylation in fibroblasts for rescuing impaired perfusion in diabetes. | tissue nanotransfection (tnt) topically delivers etv2, foxc2, and fli1 (eff) plasmids increasing vasculogenic fibroblasts (vf) and promoting vascularization in ischemic murine skin. human dermal fibroblasts respond to eff nanoelectroporation with elevated expression of endothelial genes in vitro, which is linked to increased ten-eleven translocase 1/2/3 (tet) expression. single cell rna sequencing dependent validation of vf induction reveals a tet-dependent transcript signature. tnt<sub>eff</sub> also induces tet expression in vivo, and fibroblast-specific eff overexpression leads to vf-transition, with tet-activation correlating with higher 5-hydroxymethylcytosine (5-hmc) levels in vf. vf emergence requires tet-dependent demethylation of endothelial genes in vivo, enhancing vf abundance and restoring perfusion in diabetic ischemic limbs. tnt<sub>eff</sub> improves perfusion and wound closure in diabetic mice, while increasing vf in cultured human skin explants. suppressed in diabetes, tet1/2/3 play a critical role in tnt-mediated vf formation which supports de novo blood vessel development to rescue diabetic ischemic tissue. | nature communications | eng | 2024 | Nov | Mohanty Sujit K, Singh Kanhaiya, Kumar Manishekhar, Verma Sumit S, Srivastava Rajneesh, Gnyawali Surya C, Palakurti Ravichand, Sahi Ajay K, El Masry Mohamed S, Banerjee Pradipta, Kacar Sedat, Rustagi Yashika, Verma Priyanka, Ghatak Subhadip, Hernandez Edward, Rubin J Peter, Khanna Savita, Roy Sashwati, Yoder Mervin C, Sen Chandan K | mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., indiana center for regenerative medicine and engineering, indiana university school of medicine, indianapolis, in, usa., indiana center for regenerative medicine and engineering, indiana university school of medicine, indianapolis, in, usa., indiana center for regenerative medicine and engineering, indiana university school of medicine, indianapolis, in, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., indiana center for regenerative medicine and engineering, indiana university school of medicine, indianapolis, in, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa., mcgowan institute for regenerative medicine, university of pittsburgh, pittsburgh, pa, usa. c.k.sen@pitt.edu. | nature communications | nat commun | 2041-1723 | 14.7 | 16.1 | MULTIDISCIPLINARY SCIENCES|Q1|8/134 | university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, indiana university school of medicine, indiana university school of medicine, indiana university school of medicine, university of pittsburgh, indiana university school of medicine, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh, university of pittsburgh | Unknown | indiana university | 198 | 38.4 | 198.0 | Low (0-50) | |
| 47 | 46 | exercise training counteracts compromised mitochondrial capacity induced by energy restriction in prediabetics in a sex-dependent manner. | the objective of this randomized controlled trial was to examine if exercise training can counteract energy restriction-induced impairment of mitochondrial capacity in skeletal muscle of 55-70-years people with prediabetes and metabolic syndrome. the potential impact of sex was explored. fifty sedentary men and women with prediabetes and metabolic syndrome (age: 61 ± 6 (±sd) years, bmi: 29.6 ± 4.7 kg·m<sup>-2</sup>, body fat content: 37.5% ± 8.2% and vo<sub>2max</sub>: 22.3 ± 5.7 ml·min<sup>-1</sup>·kg<sup>-1</sup>) were randomized to either exercise training and dietary advice (ex-di) or dietary advice only (di). dietary advice aimed to induce weight loss and improve glycemic control. exercise consisted of 32 ± 2 mixed 30-60 min training sessions with recreational small-sided soccer distributed across 16 weeks. maximal activity and protein abundance of key regulatory mitochondrial enzymes were determined in m. vastus lateralis pre- and post-intervention. muscle glycogen content was also determined. dietary advice only (di), impaired (p < 0.001) citrate synthase (cs), and 3-hydroxyacyl-coa dehydrogenase (had) maximal activity by 18% ± 43% and 23% ± 19%, respectively. when combined with exercise training, no dietary impairment of cs or had maximal activity was detectable. superoxide dismutase 2 (sod2) and cs protein expression also declined (p < 0.05) in di and remained unchanged in ex-di. in terms of sex differences, a decrease in maximal cs activity in both ex-di and di was observed exclusively in men (all p < 0.05). in conclusion, 16 weeks of exercise training counteracts energy restriction-induced impairment in skeletal mitochondrial function in 55- to 70-year-old women and men with prediabetes and metabolic syndrome. | scandinavian journal of medicine & science in sports | eng | 2024 | Dec | Mohr Magni, Aragón Vela Jerónimo, Skoradal May-Britt, Thomassen Martin, Skriver Søren Andersen, Hansen Mette, Fatouros Ioannis G, Krustrup Peter, Nordsborg Nikolai B | centre of health sciences, faculty of health science, university of the faroe islands, tórshavn, faroe islands., department of nutrition, exercise and sports (nexs), university of copenhagen, copenhagen, denmark., centre of health sciences, faculty of health science, university of the faroe islands, tórshavn, faroe islands., department of nutrition, exercise and sports (nexs), university of copenhagen, copenhagen, denmark., department of public health, research unit for exercise biology, aarhus university, aarhus, denmark., department of public health, research unit for exercise biology, aarhus university, aarhus, denmark., department of physical education and sport science, university of thessaly, trikala, greece., department of sports science and clinical biomechanics, sdu sport and health sciences cluster (shsc), faculty of health sciences, university of southern denmark, odense, denmark., department of nutrition, exercise and sports (nexs), university of copenhagen, copenhagen, denmark. | scandinavian journal of medicine & science in sports | scand j med sci spor | 0905-7188 | 1600-0838 | 3.5 | 4.1 | SPORT SCIENCES|Q1|15/127 | centre of health sciences, faculty of health science, university of the faroe islands, university of copenhagen, centre of health sciences, faculty of health science, university of the faroe islands, university of copenhagen, department of public health, aarhus university, department of public health, aarhus university, university of thessaly, faculty of health sciences, university of southern denmark, university of copenhagen | exercise training | aarhus university | 109 | 59.0 | 109.0 | Medium (50-75) |
| 48 | 47 | topical delivery of gel-in-oil emulsion cocktail with growth factors for the treatment of diabetic pressure ulcers. | healing diabetic foot ulcers (dfus) poses a serious challenge for many individuals with diabetes. the use of biomaterials applied locally for treating dfus has recently garnered significant attention. here, we present a gel-in-oil nanogel dispersion (g/o-ngd) capable of local delivery of six different growth factors (gfs) via the topical route, followed by an in-vivo evaluation in mice. both macroscopic and microscopic changes in skin structure were evidented after topical application of gf-cocktail g/o-ngd, and changes in cd68 and cd31 levels and collagen content were measured. expression and synthesis of interleukin-6 (il-6), transforming gf beta 1 (tgf-β1), and basic fibroblast gf (bfgf) were also analyzed. the results showed that a significant reduction in ulcer area, restoration of skin structure, increase in collagen content, angiogenesis, and suppression of inflammation were possible with gf-cocktail g/o-ngd, indicating that g/o-ngd is a prospective carrier for local delivery of gf, improving wound healing processes. | journal of bioscience and bioengineering | eng | 2024 | Nov | Zhang Yi, Fardous Jannatul, Zhou Yu, Wu Lichun, Doi Ryota, Hu Jia, Hirota Yuya, Ikegami Yasuhiro, Aishima Shinichi, Ijima Hiroyuki | department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: zhang_yi@ms.ifoc.kyushu-u.ac.jp., department of pharmacy, faculty of science, comilla university, cumilla 3506, bangladesh. electronic address: fardousj11@cou.ac.bd., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: zhou.yu.222@s.kyushu-u.ac.jp., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: wu.lichun.820@s.kyushu-u.ac.jp., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: doi.ryota.691@kyudai.jp., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: hu.jia.511@s.kyushu-u.ac.jp., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: hirota.yuya.503@s.kyushu-u.ac.jp., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: yikegami@chem-eng.kyushu-u.ac.jp., department of scientific pathology, graduate school of medical sciences, kyushu university, 3-1-1 maidashi, higashi-ku, fukuoka 812-8582, japan. electronic address: aishima.shinichi.476@m.kyushu-u.ac.jp., department of chemical engineering, faculty of engineering, graduate school, kyushu university, 744 motooka, nishi-ku, fukuoka 819-0395, japan. electronic address: ijima@chem-eng.kyushu-u.ac.jp. | journal of bioscience and bioengineering | j biosci bioeng | 1389-1723 | 1347-4421 | 2.3 | 2.6 | FOOD SCIENCE & TECHNOLOGY|Q3|99/173 | kyushu university, comilla university, faculty of engineering, kyushu university, faculty of engineering, kyushu university, faculty of engineering, kyushu university, faculty of engineering, kyushu university, faculty of engineering, kyushu university, faculty of engineering, kyushu university, kyushu university, faculty of engineering, kyushu university | in-vivo evaluation | kyushu university | 301–350 | 47.5 | 325.5 | Low (0-50) |
| 49 | 48 | why exercise may never be effective medicine: an evolutionary perspective on the efficacy versus effectiveness of exercise in treating type 2 diabetes. | most cases of type 2 diabetes (t2d) can be prevented by adopting a healthy lifestyle, highlighting that lifestyle modifications should be the primary defence against developing t2d. although accumulating evidence suggests that exercise can be an efficacious therapy for t2d, especially in conjunction with pharmacological interventions, its long-term effectiveness remains controversial owing to significant adherence challenges. in this narrative review, we combine an evolutionary perspective with epidemiological and prospective interventional studies to examine the efficacy versus effectiveness of varying volumes of exercise prescriptions for treating t2d. commonly prescribed and recommended volumes of moderate-intensity physical activity (150 min/week) have demonstrated low-to-moderate efficacy in improving glycaemic control, reflected by improvements in glycated haemoglobin levels. higher exercise volumes have been shown to enhance efficacy. while exercise can be moderately efficacious under the optimal circumstances of short-term exercise interventions (≤1 year), there is little evidence of its long-term effectiveness, primarily due to poor adherence. to date, no study has demonstrated long-term adherence to exercise programmes in individuals with t2d (>1 year). from an evolutionary perspective, the finding that exercise interventions are often ineffective over time is unsurprising. although often overlooked, humans never evolved to exercise. exercise is a counter-instinctive behaviour that can be difficult to maintain, even in healthy populations and can be especially challenging for individuals who are unfit or have t2d morbidities. we conclude by presenting several considerations informed by evolutionary logic that may be useful for practitioners, policymakers and advocates of exercise as medicine to improve exercise adherence. | british journal of sports medicine | eng | 2024 | Nov | MacDonald Christopher, Bennekou Mia, Midtgaard Julie, Langberg Hennig, Lieberman Daniel | centre of inflammation and metabolism and the centre for physical activity research, university of copenhagen, kobenhavn, denmark., grace health and performance enhancement, copenhagen, denmark., department of public health, university of copenhagen, kobenhavn, denmark., department of public health, university of copenhagen, kobenhavn, denmark., human evolutionary biology, harvard university, cambridge, massachusetts, usa danlieb@fas.harvard.edu. | british journal of sports medicine | brit j sport med | 0306-3674 | 1473-0480 | 11.6 | 14.4 | SPORT SCIENCES|Q1|1/127 | university of copenhagen, department of public health, university of copenhagen, department of public health, university of copenhagen, harvard university | prospective interventional studies | harvard university | 4 | 99.9 | 4.0 | High (75-100) |
| 50 | 49 | 2-fold more cardiovascular disease events decades before type 2 diabetes diagnosis: a nationwide registry study. | the risk of cardiovascular disease (cvd) is increased in individuals with type 2 diabetes mellitus (t2dm), but it remains uncertain how long an elevated cvd occurrence precedes diabetes diagnosis. | journal of the american college of cardiology | eng | 2024 | Dec | Gyldenkerne Christine, Kahlert Johnny, Thrane Pernille G, Olesen Kevin K W, Mortensen Martin B, Sørensen Henrik T, Thomsen Reimar W, Maeng Michael | department of cardiology, aarhus university hospital, aarhus n, denmark; department of clinical epidemiology, aarhus university and aarhus university hospital, aarhus, denmark. electronic address: chgyld@clin.au.dk., department of clinical epidemiology, aarhus university and aarhus university hospital, aarhus, denmark., department of cardiology, aarhus university hospital, aarhus n, denmark., department of cardiology, aarhus university hospital, aarhus n, denmark., department of cardiology, aarhus university hospital, aarhus n, denmark; ciccarone center for the prevention of cardiovascular disease, department of cardiology, johns hopkins, baltimore, maryland, usa., department of clinical epidemiology, aarhus university and aarhus university hospital, aarhus, denmark., department of clinical epidemiology, aarhus university and aarhus university hospital, aarhus, denmark., department of cardiology, aarhus university hospital, aarhus n, denmark; department of clinical medicine, aarhus university hospital, aarhus n, denmark. | journal of the american college of cardiology | j am coll cardiol | 0735-1097 | 1558-3597 | 21.7 | 24.2 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q1|4/220 | department of cardiology, aarhus university, department of clinical epidemiology, aarhus university, aarhus university, department of clinical epidemiology, aarhus university, aarhus university, department of cardiology, aarhus university, department of cardiology, aarhus university, department of cardiology, aarhus university, ciccarone center for the prevention of cardiovascular disease, department of cardiology, aarhus university, aarhus university, aarhus university, aarhus university, department of cardiology, aarhus university, aarhus university | Unknown | aarhus university | 109 | 59.0 | 109.0 | Medium (50-75) |
| 51 | 50 | diabetes and suicide: a nationwide longitudinal cohort study among the japanese working-age population. | although the mental health burden of diabetes has received substantial attention, there is limited evidence on whether the risk of suicide-a severe consequence of mental health problems-increases among individuals with diabetes. therefore, this study investigated the association between diabetes and suicide in japan. | journal of epidemiology and community health | eng | 2024 | Nov | Komura Yoshikazu, Inoue Kosuke, Ishimura Nana, Taura Daisuke, Harada Norio, Inagaki Nobuya, Kondo Naoki | department of social epidemiology, kyoto university graduate school of medicine, kyoto, kyoto, japan., department of social epidemiology, kyoto university graduate school of medicine, kyoto, kyoto, japan koinoue@ucla.edu., department of social epidemiology, kyoto university graduate school of medicine, kyoto, kyoto, japan., faculty of medicine, department of diabetes, endocrinology and nutrition, kyoto university graduate school of medicine, kyoto, kyoto, japan., department of endocrinology and metabolism, university of fukui school of medical sciences, yoshida-gun, fukui, japan., faculty of medicine, department of diabetes, endocrinology and nutrition, kyoto university graduate school of medicine, kyoto, kyoto, japan., department of social epidemiology, kyoto university graduate school of medicine, kyoto, kyoto, japan. | journal of epidemiology and community health | j epidemiol commun h | 0143-005X | 1470-2738 | 4.9 | 4.7 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH|Q1|36/403 | kyoto university, kyoto university, kyoto university, faculty of medicine, kyoto university, university of fukui school of medical sciences, faculty of medicine, kyoto university, kyoto university | Unknown | kyoto university | 55 | 84.3 | 55.0 | High (75-100) |
| 52 | 51 | a real-world disproportionality analysis of tirzepatide-related adverse events based on the fda adverse event reporting system (faers) database. | tirzepatide is a novel drug for the treatment of type 2 diabetes mellitus and chronic weight management, and there is an urgent need to explore its safety profile. the fda adverse event reporting system (faers) database provides a reliable pathway for adverse event (ae) disproportionality analysis. data regarding aes registered in the faers between q2 2022 and q4 2023 were collected for this study. the reporting odds ratio (ror) method was applied to analyse the association between tirzepatide use and the risk of developing aes. the occurrence of ≥3 aes with an ror value 95% confidence interval (ci) lower limit >1 was considered to indicate statistical significance. data on 638,153 aes were collected from the faers database, and tirzepatide use was implicated for 8,096 of those aes. a total of 98 preferred terms (pts) were detected as positive signals for tirzepatide use. frequently observed expected aes included injection site pain, nausea, injection site haemorrhage, diarrhoea, and vomiting. some unexpected aes that were frequently observed included incorrect doses, off-label use, the administration of extra doses, an inappropriate schedule of product administration, and increased blood glucose. in this study, we identified potential novel and unexpected ae signals associated with tirzepatide use. our findings confirm the importance of real-world disproportionality analysis in identifying the safety profile of new drugs, ultimately contributing to the safe clinical application of tirzepatide. | endocrine journal | eng | 2024 | Nov | Li Jie, Xie Jun, Han Yi, Zhang Wei, Wang Yilei, Jiang Zhitao | department of pharmacy, zhangjiagang tcm hospital, affiliated to nanjing university of chinese medicine, zhangjiagang, jiangsu 215600, china., department of pharmacy, zhangjiagang tcm hospital, affiliated to nanjing university of chinese medicine, zhangjiagang, jiangsu 215600, china., department of pharmacy, zhangjiagang tcm hospital, affiliated to nanjing university of chinese medicine, zhangjiagang, jiangsu 215600, china., department of pharmacy, zhangjiagang tcm hospital, affiliated to nanjing university of chinese medicine, zhangjiagang, jiangsu 215600, china., department of pharmacy, taicang tcm hospital, affiliated to nanjing university of chinese medicine, taicang, jiangsu 215400, china., department of pharmacy, zhangjiagang tcm hospital, affiliated to nanjing university of chinese medicine, zhangjiagang, jiangsu 215600, china. | endocrine journal | endocr j | 0918-8959 | 1348-4540 | 1.3 | 1.7 | ENDOCRINOLOGY & METABOLISM|Q4|155/186 | nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine | Unknown | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) |
| 53 | 52 | enhanced transdermal delivery of insulin by choline-based ionic liquids. | ionic liquids (ils) show promises as chemical penetration enhancers (cpes) for transdermal delivery of macromolecular drugs. however, their high viscosity and strong drug-il affinity may limit drug diffusion and release from the drug-loaded il (one-step strategy). herein, a two-step strategy was used by applying choline-based ils as pretreatment agents followed by insulin solution to improve penetration. insulin remained stable in the ils and are released slowly from the il matrices. in vitro and in vivo studies showed that two-step treatment enhanced insulin penetration compared to one-step treatment, with choline citrate ([ch][ci]) and choline geranate ([ch][ge]) performing the best. in a diabetic rat model, two-step treatment with [ch][ge] reduced blood glucose levels to below 80% within 8 h, while one-step treatment only maintained for 12 h. trans-epidermal water loss and molecular dynamics simulations suggested that variations in release rates and skin condition accounted for the differences between the two strategies. physical characterization confirmed that ils enhanced transdermal delivery of insulin by permeabilizing stratum corneum and opening tight junctions. preliminary safety assessment indicated mild irritation by [ch][ge], whereas [ch][ci] showed good biocompatibility. it is concluded that ils hold potential in enhancing transdermal delivery of insulin. | international journal of pharmaceutics | eng | 2024 | Nov | Li Yang, Yu Qin, Lu Yi, He Haisheng, Qi Jianping, Tai Zongguang, Chen Zhongjian, Zhu Quangang, Wu Wei | school of pharmacy, fudan university, key laboratory of smart drug delivery, ministry of education, shanghai 201203, china., school of pharmacy, fudan university, key laboratory of smart drug delivery, ministry of education, shanghai 201203, china; shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china., school of pharmacy, fudan university, key laboratory of smart drug delivery, ministry of education, shanghai 201203, china; shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china; fudan zhangjiang institute, shanghai 201203, china., school of pharmacy, fudan university, key laboratory of smart drug delivery, ministry of education, shanghai 201203, china., school of pharmacy, fudan university, key laboratory of smart drug delivery, ministry of education, shanghai 201203, china; shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china., shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china., shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china., shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china. electronic address: zhuqg@shskin.com., school of pharmacy, fudan university, key laboratory of smart drug delivery, ministry of education, shanghai 201203, china; shanghai skin disease hospital, tongji university school of medicine, shanghai 200443, china; center for medical research and innovation, shanghai pudong hospital, fudan university pudong medical centre, shanghai 201399, china; fudan zhangjiang institute, shanghai 201203, china. electronic address: wuwei@shmu.edu.cn. | international journal of pharmaceutics | int j pharmaceut | 0378-5173 | 1873-3476 | 5.3 | 5.6 | PHARMACOLOGY & PHARMACY|Q1|34/354 | fudan university, ministry of education, fudan university, ministry of education, tongji university, fudan university, ministry of education, tongji university, fudan zhangjiang institute, fudan university, ministry of education, fudan university, ministry of education, tongji university, tongji university, tongji university, tongji university, fudan university, ministry of education, tongji university, fudan university, fudan zhangjiang institute | in vitro | fudan university | 44 | 75.3 | 44.0 | High (75-100) |
| 54 | 53 | a comprehensive pharmacokinetic strategy for systematic evaluation of whole interaction of different constituents in astragali radix -fructus corni to improve diabetic kidney disease. | astragali-radix (the dried root of astragalus mongholicus bunge, ar) - fructus corni (the dried ripe fruit of cornus officinalis sieb. et zucc., fc) has been used as a herb-pair remedy to treat diabetic kidney disease (dkd) for hundred years. polysaccharides, saponins, and flavonoids in ar, and the iridoid glycosides in fc were deemed as the main bioactive constituents that can offer beneficial nephroprotective activities. a systematic evaluation of the nephroprotective effects of ar-fc herb pair, the main bioactive constituents extracted from the herb pair, and their combinations in different ratios was performed, cg<sub>6</sub> (polysaccharides, flavonoids, saponins, and iridoid glycosides, in a ratio of 2:3:1:2) as the best compatibility proportion was screened out in our previous study. | journal of ethnopharmacology | eng | 2024 | Nov | Duan Yu, Pei Ke, Liu Xue, Zhang Xia, Song Peixiang, Tu Sicong, Zhu Hui, Cai Hao | school of pharmacy, nanjing university of chinese medicine, nanjing 210023, pr china; engineering center of state ministry of education for standardization of chinese medicine processing, nanjing university of chinese medicine, nanjing 210023, pr china. electronic address: duanyu1681@sina.com., school of chinese medicine and food engineering, shanxi university of chinese medicine, jinzhong 030619, pr china. electronic address: peike_pk@126.com., school of pharmacy, nanjing university of chinese medicine, nanjing 210023, pr china; engineering center of state ministry of education for standardization of chinese medicine processing, nanjing university of chinese medicine, nanjing 210023, pr china. electronic address: lx0915m@163.com., school of pharmacy, nanjing university of chinese medicine, nanjing 210023, pr china; engineering center of state ministry of education for standardization of chinese medicine processing, nanjing university of chinese medicine, nanjing 210023, pr china. electronic address: zx23427972@163.com., school of pharmacy, nanjing university of chinese medicine, nanjing 210023, pr china; engineering center of state ministry of education for standardization of chinese medicine processing, nanjing university of chinese medicine, nanjing 210023, pr china. electronic address: songpeixianga@163.com., brain & mind centre, faculty of medicine & health, the university of sydney, camperdown, nsw 2050, australia. electronic address: sicong.tu@sydney.edu.au., school of pharmacy, nanjing university of chinese medicine, nanjing 210023, pr china; engineering center of state ministry of education for standardization of chinese medicine processing, nanjing university of chinese medicine, nanjing 210023, pr china. electronic address: zhui_0826@njucm.edu.cn., school of pharmacy, nanjing university of chinese medicine, nanjing 210023, pr china; engineering center of state ministry of education for standardization of chinese medicine processing, nanjing university of chinese medicine, nanjing 210023, pr china. electronic address: haocai@njucm.edu.cn. | journal of ethnopharmacology | j ethnopharmacol | 0378-8741 | 1872-7573 | 4.8 | 4.8 | PLANT SCIENCES|Q1|31/265 | nanjing university of chinese medicine, state ministry of education, nanjing university of chinese medicine, shanxi university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, the university of sydney, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine, nanjing university of chinese medicine | systematic evaluation | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) |
| 55 | 54 | association of glucagon-like peptide-1 receptor agonists use with fracture risk in type 2 diabetes: a meta-analysis of randomized controlled trials. | type 2 diabetes mellitus (t2dm) is associated with an increased risk of osteoporosis (op) and fractures. | bone | eng | 2024 | Nov | Zhang Yuan, Chen Guanhua, Wang Weimin, Yang Donghui, Zhu Dalong, Jing Yali | department of endocrinology, endocrine and metabolic disease medical center, nanjing drum tower hospital clinical college of nanjing university of chinese medicine, nanjing, china; branch of national clinical research centre for metabolic diseases, nanjing, china., department of endocrinology, endocrine and metabolic disease medical center, nanjing drum tower hospital clinical college of nanjing university of chinese medicine, nanjing, china; branch of national clinical research centre for metabolic diseases, nanjing, china., branch of national clinical research centre for metabolic diseases, nanjing, china; department of endocrinology, endocrine and metabolic disease medical center, nanjing drum tower hospital, affiliated hospital of medical school, nanjing university, nanjing, china., branch of national clinical research centre for metabolic diseases, nanjing, china; department of endocrinology, endocrine and metabolic disease medical center, nanjing drum tower hospital, affiliated hospital of medical school, nanjing university, nanjing, china., branch of national clinical research centre for metabolic diseases, nanjing, china; department of endocrinology, endocrine and metabolic disease medical center, nanjing drum tower hospital, affiliated hospital of medical school, nanjing university, nanjing, china. electronic address: zhudalong@nju.edu.cn., department of endocrinology, endocrine and metabolic disease medical center, nanjing drum tower hospital clinical college of nanjing university of chinese medicine, nanjing, china; branch of national clinical research centre for metabolic diseases, nanjing, china. electronic address: jingyalidr@163.com. | bone | bone | 8756-3282 | 1873-2763 | 3.5 | 3.8 | ENDOCRINOLOGY & METABOLISM|Q2|68/186 | nanjing university of chinese medicine, national clinical research centre for metabolic diseases, nanjing university of chinese medicine, national clinical research centre for metabolic diseases, national clinical research centre for metabolic diseases, nanjing drum tower hospital, affiliated hospital of medical school, nanjing university, national clinical research centre for metabolic diseases, nanjing drum tower hospital, nanjing university, national clinical research centre for metabolic diseases, nanjing drum tower hospital, nanjing university, nanjing university of chinese medicine, national clinical research centre for metabolic diseases | Unknown | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) |
| 56 | 55 | from oxidative stress to metabolic dysfunction: the role of trpm2. | metabolic syndromes including atherosclerosis, diabetes, obesity, and hypertension are increasingly prevalent worldwide. the disorders are the primary attributes of oxidative stress and inflammation. the transient receptor potential m2 (trpm2) channel is a pivotal mediator linking oxidative stress to metabolic dysfunction. trpm2, a non-selective cation channel activated by reactive oxygen species (ros) and adenosine diphosphate ribose (adpr), regulates calcium influx, inflammation, and cell death across various tissues. this review explores the structural and activation mechanisms of trpm2, emphasizing its significance in metabolic diseases. elevated levels of trpm2 play a vital role in the disease progression by influencing physiological and cellular processes such as endothelial dysfunction, immune cell activation, and mitochondrial impairment. in conditions such as atherosclerosis, ischemic stroke, diabetes, obesity, and hypertension; trpm2 exacerbates oxidative damage, amplifies inflammatory responses, and disrupts metabolic homeostasis. recent research highlights the potential of trpm2 as a therapeutic target, developing specified inhibitors. this review underscores the multifaceted role of trpm2 in metabolic disorders and its promise as a target for therapeutic interventions. | international journal of biological macromolecules | eng | 2024 | Nov | Li Ying-Shuang, Ren Hua-Cheng, Li Hui, Xing Man, Cao Jian-Hua | intravenous drug administration center, department of pharmacy, qingdao third people's hospital affiliated with qingdao university, qingdao, shandong 266041, pr china., intravenous drug administration center, department of pharmacy, qingdao third people's hospital affiliated with qingdao university, qingdao, shandong 266041, pr china., intravenous drug administration center, department of pharmacy, qingdao third people's hospital affiliated with qingdao university, qingdao, shandong 266041, pr china., intravenous drug administration center, department of pharmacy, qingdao third people's hospital affiliated with qingdao university, qingdao, shandong 266041, pr china., intravenous drug administration center, department of pharmacy, qingdao third people's hospital affiliated with qingdao university, qingdao, shandong 266041, pr china. electronic address: cao.jianhua@mau.edu.mk. | international journal of biological macromolecules | int j biol macromol | 0141-8130 | 1879-0003 | 7.7 | 7.7 | POLYMER SCIENCE|Q1|6/94 | department of pharmacy, qingdao university, department of pharmacy, qingdao university, department of pharmacy, qingdao university, department of pharmacy, qingdao university, department of pharmacy, qingdao university | recent research | qingdao university | 601–800 | 18.4 | 700.5 | Low (0-50) |
| 57 | 56 | nutritional label use and understanding among mexican older persons: a secondary study of national health and nutrition survey (ensanut 2021). | front package warning labeling (fwl) was implemented in mexico in 2020 as part of a strategy to raise food-related knowledge. however, limited media coverage, a lack of awareness among health professionals, and the usage of technical terminology appear to be impediments affecting many groups of the population, particularly older persons. | gaceta medica de mexico | eng | 2024 | No Data | Oca-Juárez Olaf Montes de, Fernández-Villa Julio M, González-Lara Mariana, García-Peña Carmen | school of medicine, universidad nacional autónoma de méxico, mexico city, mexico., school of medicine, universidad nacional autónoma de méxico, mexico city, mexico., faculty of health, dalhousie university, halifax, new scotland, canada., general direction, instituto nacional de geriatría, mexico city, mexico. | gaceta medica de mexico | gac med mex | 0016-3813 | 0016-3813 | 0.6 | 0.7 | MEDICINE, GENERAL & INTERNAL|Q3|219/325 | school of medicine, universidad nacional autónoma de méxico, school of medicine, universidad nacional autónoma de méxico, faculty of health, dalhousie university, general direction, instituto nacional de geriatría | Unknown | dalhousie university | 301–350 | 31.6 | 325.5 | Low (0-50) |
| 58 | 57 | effects of integrated care approaches to address co-occurring depression and diabetes: a systematic review and meta-analysis. | depressive symptoms frequently co-occur with diabetes and, when unaddressed, can function to worsen diabetes control and increase the risk of diabetes-related morbidity. integrated care (ic) approaches aim to improve outcomes among people with diabetes and depression, but there are no current meta-analyses examining their effects. | diabetes care | eng | 2024 | Dec | Cooper Zach W, O'Shields Jay, Ali Mohammed K, Chwastiak Lydia, Johnson Leslie C M | university of georgia school of social work, athens, ga., university of georgia school of social work, athens, ga., department of family and preventative medicine, school of medicine, emory university, atlanta, ga., department of psychiatry and behavioral sciences, university of washington school of medicine, seattle, wa., department of family and preventative medicine, school of medicine, emory university, atlanta, ga. | diabetes care | diabetes care | 0149-5992 | 1935-5548 | 14.8 | 14.1 | ENDOCRINOLOGY & METABOLISM|Q1|6/186 | university of georgia, university of georgia, department of family and preventative medicine, school of medicine, emory university, department of psychiatry and behavioral sciences, university of washington, school of medicine, department of family and preventative medicine, school of medicine, emory university | Unknown | emory university | 106 | 45.7 | 106.0 | Low (0-50) |
| 59 | 58 | a systematic review and meta-analysis on the safety and efficacy of sodium-glucose cotransporter 2 inhibitor use in hospitalized patients. | the safety and efficacy of sodium-glucose cotransporter 2 (sglt2) inhibitors in hospitalized patients are unclear. | diabetes care | eng | 2024 | Dec | Gao Frank M, Ali Aleena S, Bellomo Rinaldo, Gaca Michele, Lecamwasam Ashani, Churilov Leonid, Ekinci Elif I | department of endocrinology, austin hospital, melbourne, australia., department of endocrinology, austin hospital, melbourne, australia., australian and new zealand intensive care research centre, school of public health and preventive medicine, monash university, melbourne, australia., department of medicine, austin health, melbourne medical school, the university of melbourne, melbourne, australia., department of endocrinology, austin hospital, melbourne, australia., australian centre for accelerating diabetes innovations, melbourne medical school, the university of melbourne, melbourne, australia., department of endocrinology, austin hospital, melbourne, australia. | diabetes care | diabetes care | 0149-5992 | 1935-5548 | 14.8 | 14.1 | ENDOCRINOLOGY & METABOLISM|Q1|6/186 | austin hospital, austin hospital, australian and new zealand intensive care research centre, school of public health and preventive medicine, monash university, melbourne medical school, the university of melbourne, austin hospital, melbourne medical school, the university of melbourne, austin hospital | Unknown | monash university | 54 | 67.8 | 54.0 | Medium (50-75) |
| 60 | 59 | a wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models. | the maintenance of stable plasma drug concentrations within a therapeutic window can be critical for drug efficacy. here, we developed a wearable osmotic microneedle (omn) patch to support sustained drug dosing for at least 24 hours without the use of electronic components. the omn patch uses an osmotic pressure driving force to deliver drug solution into the skin through three hollow microneedles with diameters of less than 200 micrometers. the rate of drug release was related to the composition and concentration of the osmogen and drug and to the physical properties of the semipermeable membrane separating the low- and high-solute compartments. the omn patch released the peptide drug exenatide in rats and mice for 24 hours, whereas subcutaneous injection resulted in a burst release and rapid decline in the plasma drug concentration. omn release of exenatide improved glycemic control in a diabetic mouse model consistent with a sustained effective plasma concentration of the drug. continuous release of the small-molecule chemotherapeutic drug cytarabine reduced the progression of acute myeloid leukemia in mice more effectively than subcutaneous injection. further evaluation of the omn patch in canines demonstrated continuous dosing of cytarabine up to 225 milligrams for 24 hours, satisfying clinical requirements (150 to 300 milligrams daily). omn patches were well tolerated in human participants with minimal pain or irritation of the skin and a stated preference over other administration routes. this wearable drug delivery system could provide a platform for stable high-dose drug release with convenience and safety. | science translational medicine | eng | 2024 | Nov | Zhao Sheng, Lu Ziyi, Cai Ruisi, Wang Hui, Gao Shukun, Yang Changwei, Zhang Ying, Luo Bowen, Zhang Wentao, Yang Yinxian, Wang Shenqiang, Sheng Tao, Wang Shiqi, You Jiahuan, Zhou Ruyi, Ji Huimin, Gong Haoning, Ye Xiao, Yu Jicheng, Zhu Hong-Hu, Zhang Yuqi, Gu Zhen | state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., jinhua institute of zhejiang university, jinhua 321299, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., key laboratory for diagnosis and treatment of endocrine gland diseases of zhejiang province, geriatric medicine center, department of endocrinology, zhejiang provincial people's hospital (affiliated people's hospital, hangzhou medical college), hangzhou 310014, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., department of hematology, beijing chao-yang hospital, capital medical university, beijing 100020, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china., state key laboratory of advanced drug delivery and release systems, key laboratory of advanced drug delivery systems of zhejiang province, college of pharmaceutical sciences, zhejiang university, hangzhou 310058, china. | science translational medicine | sci transl med | 1946-6234 | 1946-6242 | 15.8 | 16.9 | MEDICINE, RESEARCH & EXPERIMENTAL|Q1|2/189 | college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university, college of pharmaceutical sciences, zhejiang university | Unknown | zhejiang university | 55 | 75.3 | 55.0 | High (75-100) |
| 61 | 60 | improved afternoon hepatic glucose disposal and storage requires morning engagement of hepatic insulin receptors. | glucose tolerance improves significantly upon consuming a second, identical meal later in the day (second meal phenomenon). we previously established that morning hyperinsulinemia primes the liver for increased afternoon hepatic glucose uptake (hgu). although the route of insulin delivery is an important determinant of the mechanisms by which insulin regulates liver glucose metabolism (direct hepatic vs indirect insulin action), it is not known if insulin's delivery route affects the second meal response. to determine whether morning peripheral insulin delivery (as occurs clinically, i.e. subcutaneous) can enhance afternoon hgu, conscious dogs were treated in the morning with insulin delivered either via the portal vein or peripherally (leg vein), while glucose was infused to maintain euglycemia. consequently, arterial insulin levels increased similarly in both groups, but relative hepatic insulin deficiency occurred with peripheral insulin delivery. in the afternoon, all animals were challenged with the same hyperinsulinemichyperglycemic clamp to simulate identical postprandial-like conditions. the substantial enhancement of hgu in the afternoon caused by morning portal vein insulin delivery was lost when insulin was delivered peripherally. this indicates that morning insulin does not cause the second meal phenomenon via its indirect actions on the liver, but rather through direct activation of hepatic insulin signaling. | diabetes | eng | 2024 | Nov | Waterman Hannah L, Moore Mary Courtney, Smith Marta S, Farmer Ben, Yankey Kalisha, Scott Melanie, Edgerton Dale S, Cherrington Alan D | department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine., department of molecular physiology & biophysics, vanderbilt university school of medicine. | diabetes | diabetes | 0012-1797 | 1939-327X | 6.2 | 7.1 | ENDOCRINOLOGY & METABOLISM|Q1|20/186 | vanderbilt university school of medicine, vanderbilt university school of medicine, vanderbilt university school of medicine, vanderbilt university school of medicine, vanderbilt university school of medicine, vanderbilt university school of medicine, vanderbilt university school of medicine, vanderbilt university school of medicine | Unknown | vanderbilt university | 92 | 48.5 | 92.0 | Low (0-50) |
| 62 | 61 | prescription fills among patients with type 2 diabetes after hospitalization for acute coronary syndrome. | individuals with type 2 diabetes (t2d) have high rates of mortality following myocardial infarction (mi). hospitalization is an opportunity to initiate or continue evidence-based treatment to reduce risk in individuals with t2d and acute coronary syndrome (acs). | jama network open | eng | 2024 | Nov | Kelsey Michelle D, Ford Cassie, Oakes Megan, Soneji Samir, Bosworth Hayden B, Pagidipati Neha J | division of cardiology, department of medicine, duke university, durham, north carolina., department of population health sciences, duke university, durham, north carolina., department of population health sciences, duke university, durham, north carolina., department of population health sciences, duke university, durham, north carolina., duke clinical research institute, durham, north carolina., division of cardiology, department of medicine, duke university, durham, north carolina. | jama network open | jama netw open | 2574-3805 | 2574-3805 | 10.5 | 11.0 | MEDICINE, GENERAL & INTERNAL|Q1|10/325 | division of cardiology, department of medicine, duke university, department of population health sciences, duke university, department of population health sciences, duke university, department of population health sciences, duke university, duke clinical research institute, division of cardiology, department of medicine, duke university | Unknown | duke university | 26 | 76.1 | 26.0 | High (75-100) |
| 63 | 62 | a natural eumelanin-assisted pullulan/chitosan hydrogel for the management of diabetic oral ulcers. | existing methods for treating diabetic oral ulcers often fall short in clinical environments due to potential bacterial contamination, oxidative harm, and hindered angiogenesis throughout the healing process. here, a hydrogel patch (hyg2) have been developed for local in situ application. hyg2 comprises oxidized pullulan, quaternized chitosan, and eumelanin nanoparticles derived from cuttlefish ink. these components work together to efficiently heal wounds associated with diabetic oral ulcers. application begins with a simple local injection that quickly forms a protective barrier over the mucosa, effectively stopping bleeding and counteracting inflammatory agents. hyg2 is distinguished by its strong antibacterial properties and capacity to eliminate reactive oxygen species, promoting bacteria clearance and managing oxidative stress, which accelerates the healing phase from inflammation to tissue regeneration. additionally, hyg2's 3d structure, incorporating elements from natural sources, offers exemplary support for structural and nutritional cell needs. this enhancement fosters cell adhesion, migration, and proliferation, along with further angiogenesis during mucosal remodeling. ultimately, hyg2 is fully absorbed by the body after serving its therapeutic functions. evidence from in vitro and in vivo studies shows that hyg2 hydrogel markedly accelerates mucosal wound repair, making it a promising treatment for diabetic oral ulcers. | macromolecular bioscience | eng | 2024 | Nov | Li Ying, Xiang Yajing, Chen Yuxi, Wang Yingying, Dong Wei, Liu Yan, Qi Xiaoliang, Shen Jianliang | school of chemical engineering, nanjing university of science & technology, nanjing, jiangsu, 210094, china., school & hospital of stomatology, wenzhou medical university, wenzhou, zhejiang, 325027, china., school & hospital of stomatology, wenzhou medical university, wenzhou, zhejiang, 325027, china., department of otolaryngology, the first affiliated hospital of wenzhou medical university, wenzhou, zhejiang, 325000, china., school of chemical engineering, nanjing university of science & technology, nanjing, jiangsu, 210094, china., school of chemical engineering, nanjing university of science & technology, nanjing, jiangsu, 210094, china., national engineering research center of ophthalmology and optometry, eye hospital, wenzhou medical university, wenzhou, zhejiang, 325027, china., national engineering research center of ophthalmology and optometry, eye hospital, wenzhou medical university, wenzhou, zhejiang, 325027, china. | macromolecular bioscience | macromol biosci | 1616-5187 | 1616-5195 | 4.4 | 5.0 | POLYMER SCIENCE|Q1|23/94 | nanjing university of science & technology, school & hospital of stomatology, wenzhou medical university, school & hospital of stomatology, wenzhou medical university, department of otolaryngology, wenzhou medical university, nanjing university of science & technology, nanjing university of science & technology, national engineering research center of ophthalmology and optometry, wenzhou medical university, national engineering research center of ophthalmology and optometry, wenzhou medical university | in vitro and in vivo studies | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) |
| 64 | 63 | results of an australian trial of an automated insulin delivery (aid) system and other studies support likely benefit of aid use for many australian adults with type 1 diabetes. | less than 20% of australians with type 1 diabetes (t1d) meet recommended glucose targets. technology use is associated with better glycaemia, with the most advanced being automated insulin delivery (aid) systems, which are now recommended as gold-standard t1d care. our australian aid trial shows a wide spectrum of adults with t1d can achieve recommended targets. other studies, including lived experience data, are supportive. insulin pumps are not subsidised for most australian adults with t1d. we advocate change. | internal medicine journal | eng | 2024 | Nov | Jenkins Alicia J, Januszewski Andrzej S, Kirby Adrienne, Hendrieckx Christel, McAuley Sybil A, Lee Melissa H, Paldus Barbora, Vogrin Sara, de Bock Martin I, Abraham Mary B, Bach Leon A, Burt Morton G, Cohen Neale D, Colman Peter G, Davis Elizabeth A, Holmes-Walker D J, Kaye Joey, Keech Anthony C, Kumareswaran Kavita, MacIsaac Richard J, McCallum Roland W, Sims Catriona M, Speight Jane, Stranks Stephen N, Sundararajan Vijaya, Trawley Steven, Ward Glenn M, Jones Timothy W, O'Neal David N | department of medicine, university of melbourne, melbourne, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., nhmrc clinical trials centre, university of sydney, sydney, new south wales, australia., school of psychology, institute for health transformation, deakin university, geelong, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., department of paediatrics, university of otago, christchurch, new zealand., school of paediatrics and child health, university of western australia, perth, western australia, australia., department of endocrinology and diabetes, the alfred, melbourne, victoria, australia., southern adelaide diabetes and endocrine services, flinders medical centre, adelaide, south australia, australia., baker heart and diabetes institute, melbourne, victoria, australia., department of diabetes and endocrinology, royal melbourne hospital, melbourne, victoria, australia., school of paediatrics and child health, university of western australia, perth, western australia, australia., department of diabetes and endocrinology, westmead hospital, sydney, new south wales, australia., department of endocrinology and diabetes, sir charles gairdner hospital, perth, western australia, australia., nhmrc clinical trials centre, university of sydney, sydney, new south wales, australia., baker heart and diabetes institute, melbourne, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., department of diabetes and endocrinology, royal hobart hospital, hobart, tasmania, australia., department of medicine, university of melbourne, melbourne, victoria, australia., school of psychology, institute for health transformation, deakin university, geelong, victoria, australia., southern adelaide diabetes and endocrine services, flinders medical centre, adelaide, south australia, australia., department of public health, la trobe university, melbourne, victoria, australia., cairnmillar institute, melbourne, victoria, australia., department of medicine, university of melbourne, melbourne, victoria, australia., school of paediatrics and child health, university of western australia, perth, western australia, australia., department of medicine, university of melbourne, melbourne, victoria, australia., No Affiliation | internal medicine journal | intern med j | 1444-0903 | 1445-5994 | 1.8 | 1.9 | MEDICINE, GENERAL & INTERNAL|Q2|109/325 | university of melbourne, university of melbourne, university of sydney, institute for health transformation, deakin university, university of melbourne, university of melbourne, university of melbourne, university of melbourne, university of otago, university of western australia, the alfred, flinders medical centre, baker heart and diabetes institute, royal melbourne hospital, university of western australia, sir charles gairdner hospital, university of sydney, baker heart and diabetes institute, university of melbourne, royal hobart hospital, university of melbourne, institute for health transformation, deakin university | australian aid trial | deakin university | 251–300 | 34.6 | 275.5 | Low (0-50) |
| 65 | 64 | computational modelling of valvular heart disease: haemodynamic insights and clinical implications. | an aging population and an increasing incidence of cardiovascular risk factors form the basis for a global rising prevalence of valvular heart disease (vhd). research to further our understanding of the pathophysiology of vhd is often confined to the clinical setting. however, in recent years, sophisticated computational models of the cardiovascular system have been increasingly used to investigate a variety of vhd states. computational modelling provides new opportunities to gain insights into pathophysiological processes that may otherwise be difficult, or even impossible, to attain in human or animal studies. simulations of co-existing cardiac pathologies, such as heart failure, atrial fibrillation, and mixed valvular disease, have unveiled new insights that can inform clinical research and practice. more recently, advancements have been made in using models for making patient-specific diagnostic predictions. this review showcases valuable insights gained from computational studies on vhd and their clinical implications. | frontiers in bioengineering and biotechnology | eng | 2024 | No Data | Šeman Michael, Stephens Andrew F, Kaye David M, Gregory Shaun D, Stub Dion | school of public health and preventative medicine, monash university, melbourne, vic, australia., cardio-respiratory engineering and technology laboratory, department of mechanical and aerospace engineering, monash university, melbourne, vic, australia., cardio-respiratory engineering and technology laboratory, department of mechanical and aerospace engineering, monash university, melbourne, vic, australia., cardio-respiratory engineering and technology laboratory, department of mechanical and aerospace engineering, monash university, melbourne, vic, australia., school of public health and preventative medicine, monash university, melbourne, vic, australia. | frontiers in bioengineering and biotechnology | front bioeng biotech | 2296-4185 | 2296-4185 | 4.3 | 5.1 | ENGINEERING, BIOMEDICAL|Q2|39/122 | monash university, department of mechanical and aerospace engineering, monash university, department of mechanical and aerospace engineering, monash university, department of mechanical and aerospace engineering, monash university, monash university | human or animal studies | monash university | 54 | 67.8 | 54.0 | Medium (50-75) |
| 66 | 65 | insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes. | type 1 diabetes results from the destruction of pancreatic beta cells by autoreactive t cells. as an autoantigen with extremely high expression in beta cells, insulin triggers and sustains the autoimmune cd4<sup>+</sup> and cd8<sup>+</sup> t cell responses and islet inflammation. we have previously shown that deficiency for insulin-degrading enzyme (ide), a ubiquitous cytosolic protease with very high affinity for insulin, induces endoplasmic reticulum (er) stress and proliferation in islet cells and protects non-obese diabetic mice (nod) from diabetes. here we wondered whether ide deficiency affects autoreactive cd8<sup>+</sup> t cell responses to insulin and thereby immune pathogenesis in nod mice. we find that <i>ide<sup>-/-</sup></i> nod harbor fewer diabetogenic t cells and reduced numbers of cd8<sup>+</sup> t cells recognizing the dominant autoantigen insulin and islet-specific glucose-6-phosphatase catalytic subunit-related protein (igrp). using <i>in vitro</i> digestions and cellular antigen presentation assays, we show that generation of the dominant insulin epitope b<sub>15-23</sub> involves both the proteasome and ide. ide deficiency attenuates mhc-i presentation of the immunodominant insulin epitope by beta cells to cognate cd8<sup>+</sup> t cells. consequently, <i>ide<sup>-/-</sup></i> islets display reduced susceptibility to autoimmune destruction upon grafting, and to killing by insulin-specific cd8<sup>+</sup> t cells. moreover, <i>ide<sup>-/-</sup></i> mice are partly resistant to disease transfer by cd8<sup>+</sup> t cells specific for insulin but not for igrp. thus, ide has a dual role in beta cells, regulating er stress and proliferation while at the same time promoting insulin-directed autoreactive cd8<sup>+</sup> t cell responses. | frontiers in immunology | eng | 2024 | No Data | Bessard Marie-Andrée, Moser Anna, Waeckel-Énée Emmanuelle, Lindo Vivian, Gdoura Abdelaziz, You Sylvaine, Wong F Susan, Greer Fiona, van Endert Peter | université paris cité, institut national de la santé et recherche médicale (inserm), centre national de la recherche scientifique (cnrs), institut necker enfants malades, paris, france., université paris cité, institut national de la santé et recherche médicale (inserm), centre national de la recherche scientifique (cnrs), institut necker enfants malades, paris, france., université paris cité, institut national de la santé et recherche médicale (inserm), centre national de la recherche scientifique (cnrs), institut necker enfants malades, paris, france., m-scan, wokingham, united kingdom., université paris cité, institut national de la santé et recherche médicale (inserm), centre national de la recherche scientifique (cnrs), institut necker enfants malades, paris, france., université paris cité, institut national de la santé et recherche médicale (inserm), centre national de la recherche scientifique (cnrs), institut cochin, paris, france., institute of molecular and experimental medicine, school of medicine, cardiff university, cardiff, united kingdom., m-scan, wokingham, united kingdom., université paris cité, institut national de la santé et recherche médicale (inserm), centre national de la recherche scientifique (cnrs), institut necker enfants malades, paris, france. | frontiers in immunology | front immunol | 1664-3224 | 1664-3224 | 5.7 | 6.8 | IMMUNOLOGY|Q1|38/181 | université paris cité, institut national de la santé et recherche médicale (inserm), université paris cité, centre national de la recherche scientifique (cnrs), université paris cité, université paris cité, université paris cité, institute of molecular and experimental medicine, cardiff university, université paris cité | cellular antigen presentation assays | cardiff university | 190 | 39.6 | 190.0 | Low (0-50) |
| 67 | 66 | type ii diabetes and metformin use does not affect colorectal cancer prognosis. | previous studies on the impact of metformin and colorectal cancer (crc) outcomes have been limited by small size and confounding by indication, yielding inconsistent results. the aim of this study was to assess whether diabetes and pre-diagnostic metformin use influence crc prognosis. the study was performed using the colorectal cancer data base sweden, a register-linkage originating from the swedish colorectal cancer register with linkage to national health care registers and demographic registers. all adult patients diagnosed with primary non-metastatic crc between 2007 and 2016, treated with curative surgery, were identified and followed up from 90 days post-surgery until december 31, 2022. antidiabetic medication use was defined as dispensed prescription ≥6 months of use within 1 year of surgery. type ii diabetes mellitus (t2dm) patients were divided into three treatment groups (i) diet only, (ii) metformin user, and (iii) non-metformin user. cox regression models estimated hazard ratios (hrs) with 95% confidence intervals (cis) for time to recurrence, crc-specific, and all-cause mortality, adjusted for relevant covariates. of 33,028 non-metastatic crc patients, 4539 (13.7%) had t2dm, with 1745 using metformin. a t2dm diagnosis was not associated with increased recurrence rate or crc-specific mortality; hr<sub>adj</sub> 0.97 (95% ci 0.89-1.06) and hr<sub>adj</sub> 0.95 (95% ci 0.87-1.05), respectively, compared with non-diabetic patients. furthermore, no association between t2dm, metformin use, and recurrence or crc-specific mortality was seen, hr<sub>adj</sub> 0.98 (95% ci 0.86-1.12) and hr<sub>adj</sub> 0.98 (95% ci 0.85-1.13), respectively. t2dm is not associated with an elevated recurrence or crc-specific mortality. additionally, metformin use does not impact crc prognosis. | international journal of cancer | eng | 2024 | Nov | Shahrivar Mehrnoosh, Dietrich Caroline E, Glimelius Bengt, Saraste Deborah, Martling Anna, Buchli Christian, Nordenvall Caroline | department of molecular medicine and surgery, karolinska institutet, stockholm, sweden., clinical epidemiology division, department of medicine solna, karolinska institutet, stockholm, sweden., department of immunology, genetics and pathology, uppsala university, uppsala, sweden., department of clinical science and education, karolinska institutet, stockholm, sweden., department of molecular medicine and surgery, karolinska institutet, stockholm, sweden., department of molecular medicine and surgery, karolinska institutet, stockholm, sweden., department of molecular medicine and surgery, karolinska institutet, stockholm, sweden. | international journal of cancer | int j cancer | 0020-7136 | 1097-0215 | 5.7 | 6.0 | ONCOLOGY|Q1|54/322 | department of molecular medicine and surgery, karolinska institutet, department of medicine solna, karolinska institutet, uppsala university, department of clinical science and education, karolinska institutet, department of molecular medicine and surgery, karolinska institutet, department of molecular medicine and surgery, karolinska institutet, department of molecular medicine and surgery, karolinska institutet | Unknown | karolinska institute | 50 | 67.9 | 50.0 | Medium (50-75) |
| 68 | 67 | positive changes in body composition and profiles of individuals with diabetes 3 years following laparoscopic sleeve gastrectomy in japanese patients with obesity. | we analyzed the changes in obesity, glucose metabolism, and body composition over a 3-year period in japanese patients with obesity following laparoscopic sleeve gastrectomy (lsg). | nutrients | eng | 2024 | Nov | Ozeki Yoshinori, Masaki Takayuki, Miyamoto Shotaro, Yoshida Yuichi, Okamoto Mitsuhiro, Gotoh Koro, Endo Yuichi, Inomata Masafumi, Shibata Hirotaka | department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan., department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan., department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan., department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan., department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan., department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan., obesity and diabetes center for advanced medicine, faculty of medicine, oita university, yufu city 879-5593, japan., department of gastroenterological and pediatric surgery, faculty of medicine, oita university, yufu city 879-5593, japan., department of endocrinology, metabolism, rheumatology and nephrology, faculty of medicine, oita university, yufu city 879-5593, japan. | nutrients | nutrients | 2072-6643 | 4.8 | 5.8 | NUTRITION & DIETETICS|Q1|18/114 | faculty of medicine, oita university, faculty of medicine, oita university, faculty of medicine, oita university, faculty of medicine, oita university, faculty of medicine, oita university, faculty of medicine, oita university, obesity and diabetes center for advanced medicine, faculty of medicine, oita university, faculty of medicine, oita university, faculty of medicine, oita university | Unknown | oita university | 1501+ | 11.0 | 1501.0 | Low (0-50) | |
| 69 | 68 | carnosine supplementation has no effect on inflammatory markers in adults with prediabetes and type 2 diabetes: a randomised controlled trial. | in vitro studies suggest that carnosine reduces inflammation by upregulating anti-inflammatory mediators and downregulating pro-inflammatory cytokines. however, human clinical trials examining the effects of carnosine on inflammatory biomarkers are scant. we conducted a secondary analysis of a double-blind randomised controlled trial (rct) to examine the effects of carnosine supplementation on inflammatory markers and adipokines in participants with prediabetes or well-controlled type 2 diabetes (t2d). | nutrients | eng | 2024 | Nov | Saadati Saeede, de Courten Maximilian, Deceneux Cyril, Plebanski Magdalena, Scott David, Mesinovic Jakub, Jansons Paul, Aldini Giancarlo, Cameron James, Feehan Jack, Mousa Aya, de Courten Barbora | monash centre for health research and implementation (mchri), faculty of medicine, nursing and health sciences, monash university, clayton, vic 3168, australia., australian health policy collaboration, institute for health and sport (ihes), victoria university, melbourne, vic 8001, australia., cancer aging and vaccine laboratory, school of health and biomedical sciences, rmit university, bundoora, vic 3083, australia., cancer aging and vaccine laboratory, school of health and biomedical sciences, rmit university, bundoora, vic 3083, australia., institute for physical activity and nutrition (ipan), school of exercise and nutrition sciences, deakin university, geelong, vic 3220, australia., institute for physical activity and nutrition (ipan), school of exercise and nutrition sciences, deakin university, geelong, vic 3220, australia., institute for physical activity and nutrition (ipan), school of exercise and nutrition sciences, deakin university, geelong, vic 3220, australia., department of pharmaceutical sciences, university of milan, 20133 milan, italy., school of clinical sciences, faculty of medicine, nursing and health sciences, monash university, clayton, vic 3168, australia., school of health and biomedical sciences, rmit university, bundoora, vic 3083, australia., monash centre for health research and implementation (mchri), faculty of medicine, nursing and health sciences, monash university, clayton, vic 3168, australia., school of clinical sciences, faculty of medicine, nursing and health sciences, monash university, clayton, vic 3168, australia. | nutrients | nutrients | 2072-6643 | 4.8 | 5.8 | NUTRITION & DIETETICS|Q1|18/114 | monash centre for health research and implementation (mchri), monash university, victoria university, rmit university, rmit university, institute for physical activity and nutrition (ipan), deakin university, deakin university, deakin university, university of milan, monash university, rmit university, monash university, monash university | human clinical trials | monash university | 54 | 67.8 | 54.0 | Medium (50-75) | |
| 70 | 69 | untargeted lipidomic profiling of amniotic fluid reveals dysregulated lipid metabolism in healthy normal-weight mothers with fetal macrosomia. | alterations in maternal lipid metabolism have been elucidated by several studies in relation to macrosomia. however, the lipidome of the intrauterine compartment associated with macrosomia, particularly in early pregnancy, remains largely unknown. | nutrients | eng | 2024 | Nov | Haj-Husein Isra'a, Kubow Stan, Koski Kristine G | school of human nutrition, mcgill university, ste-anne de bellevue, qc h9x 3v9, canada., school of human nutrition, mcgill university, ste-anne de bellevue, qc h9x 3v9, canada., school of human nutrition, mcgill university, ste-anne de bellevue, qc h9x 3v9, canada. | nutrients | nutrients | 2072-6643 | 4.8 | 5.8 | NUTRITION & DIETETICS|Q1|18/114 | school of human nutrition, mcgill university, school of human nutrition, mcgill university, school of human nutrition, mcgill university | several studies | mcgill university | 49 | 72.3 | 49.0 | Medium (50-75) | |
| 71 | 70 | diet-wide association study for the incidence of type 2 diabetes in three population-based cohorts. | dietary factors are well-known modifiable risk factors for type 2 diabetes (t2d), but many studies overlook the interrelationships between these factors, even though foods are often consumed together and contain a variety of nutrients. | nutrients | eng | 2024 | Nov | Woo Hye Won, Hoang Manh Thang, Shin Min-Ho, Koh Sang Baek, Kim Hyeon Chang, Kim Yu-Mi, Kim Mi Kyung | department of preventive medicine, college of medicine, hanyang university, seoul 15588, republic of korea., department of preventive medicine, college of medicine, hanyang university, seoul 15588, republic of korea., department of preventive medicine & institute of wonkwang medical science, wonkwang university school of medicine, iksan 35233, republic of korea., department of preventive medicine, keimyung university dongsan medical center, daegu 42601, republic of korea., department of preventive medicine, chonnam national university medical school, gwangju 61186, republic of korea., department of preventive medicine, college of medicine, hanyang university, seoul 15588, republic of korea., department of preventive medicine, college of medicine, hanyang university, seoul 15588, republic of korea. | nutrients | nutrients | 2072-6643 | 4.8 | 5.8 | NUTRITION & DIETETICS|Q1|18/114 | college of medicine, hanyang university, republic of korea, college of medicine, hanyang university, republic of korea, wonkwang university, republic of korea, keimyung university dongsan medical center, chonnam national university medical school, college of medicine, hanyang university, college of medicine, hanyang university | studies | hanyang university | 301–350 | 40.4 | 325.5 | Low (0-50) | |
| 72 | 71 | depression in cardiac patients is a major cardiovascular event risk factor: a 12-month observational study. | <b>background</b>: depression is a known factor in poor cardiovascular outcomes but is often underassessed in cardiac units. this study evaluates the impact of depression on cardiovascular outcomes in patients undergoing cardiac interventions. <b>methods:</b> the study included 133 patients who underwent uncomplicated procedures for degenerative aortic valve stenosis (n = 40), acute coronary syndrome (n = 29), or chronic coronary artery disease (n = 64). depression was assessed using the beck depression inventory (bdi) and hamilton depression rating scale (ham-d). the primary endpoint was a major adverse cardiac and cerebrovascular event (macce). patients were followed up for 12 months. cox proportional hazards analysis was used to identify macce risk factors. <b>results</b>: depression was more frequently screened by ham-d than bdi (42.9% vs. 30.8%, <i>p</i> < 0.001). during follow-up, 26 (19.5%) macces occurred. in univariate analysis, risk factors included bdi score ≥ 11, ham-d score ≥ 8, diabetes on insulin, anticoagulant use, atrial fibrillation, and serum creatinine level ≥ 130 µmol/l. depression in the bdi increased the risk of the macce 3.6-fold (95%ci: 1.64-8.0, <i>p</i> = 0.001), whereas in the ham-d, it increased the risk 4.9-fold (95%ci: 1.97-12.24, <i>p</i> < 0.001). multivariate analysis showed ham-d score ≥ 8 as the strongest predictor of macce (hr: 3.08, 95%ci: 1.18-8.08). <b>conclusions</b>: depression is a common finding in cardiovascular patients, and it is a strong risk factor for one-year cardiovascular mortality and adverse event risk. therefore, we believe that common guidelines should be elaborated between relevant psychiatry and cardiology scientific societies. | journal of clinical medicine | eng | 2024 | Nov | Podolec Jakub, Kleczyński Paweł, Piechocki Marcin, Okarski Michał, Lizończyk Katarzyna, Szkodoń Kornelia, Silczuk Andrzej, Przewłocki Tadeusz, Legutko Jacek, Kabłak-Ziembicka Anna | department of interventional cardiology, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland., department of interventional cardiology, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland., department of cardiac and vascular diseases, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland., department of interventional cardiology, the st. john paul ii hospital, 31-202 kraków, poland., students' scientific group of modern cardiac therapy, department of interventional cardiology, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland., students' scientific group of modern cardiac therapy, department of interventional cardiology, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland., department of environmental psychiatry, faculty of life sciences, medical university of warsaw, 02-091 warsaw, poland., department of interventional cardiology, the st. john paul ii hospital, 31-202 kraków, poland., department of interventional cardiology, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland., department of cardiac and vascular diseases, institute of cardiology, jagiellonian university medical college, 31-007 kraków, poland. | journal of clinical medicine | j clin med | 2077-0383 | 3.0 | 3.4 | MEDICINE, GENERAL & INTERNAL|Q1|58/325 | institute of cardiology, jagiellonian university medical college, institute of cardiology, jagiellonian university medical college, institute of cardiology, jagiellonian university medical college, department of interventional cardiology, the st. john paul ii hospital, institute of cardiology, jagiellonian university medical college, institute of cardiology, jagiellonian university medical college, faculty of life sciences, medical university of warsaw, department of interventional cardiology, the st. john paul ii hospital, institute of cardiology, jagiellonian university medical college, institute of cardiology, jagiellonian university medical college | Unknown | jagiellonian university | 601–800 | 29.0 | 700.5 | Low (0-50) | |
| 73 | 72 | impact of individual characteristics on hospital outcomes in exacerbated copd in a biomass-exposed turkish population. | <b>background</b>: chronic obstructive pulmonary disease (copd) is a leading cause of morbidity and mortality globally, and factors such as biomass exposure, demographic characteristics, and comorbidities significantly influence patient outcomes during exacerbations. <b>aim</b>: this study aims to clarify the impact of patient characteristics on key hospital outcomes, including icu admissions, hospital length of stay, and in-hospital mortality, focusing on the contextual role of biomass exposure rather than its direct impact. <b>methods</b>: using a multicenter, retrospective cohort design, we analyzed the medical records of patients admitted with copd exacerbations from january 2021 to december 2023. eligible patients were over 40 years old with confirmed copd exacerbation, excluding those with other significant lung conditions, severe organ dysfunction, or incomplete data. the collected data included demographics, smoking history, comorbidities, medications, laboratory results, and clinical outcomes, with smoking status categorized into current, former, or never smokers. <b>results</b>: our analysis comprised 334 patients with a mean age of 69 ± 8.8 years, including 52 (15.6%) females. biomass exposure, observed in 22% of patients, was associated with a higher likelihood of being female (<i>p</i> < 0.001), lower smoking rates (<i>p</i> < 0.001), higher prevalence of diabetes mellitus type 2 (<i>p</i> = 0.020), lower peripheral blood eosinophilia (<i>p</i> = 0.001), increased intensive care unit (icu) admissions (<i>p</i> = 0.034), and higher in-hospital mortality (<i>p</i> = 0.043). non-survivors tended to be older and had a higher prevalence of hypertension, a history of childhood pneumonia, longer copd duration, greater need for non-invasive ventilation (niv) during hospitalization, and more frequent icu admissions. univariate cox regression analysis revealed no significant associations between characteristics and outcomes. <b>conclusions</b>: patients with biomass exposure were more likely to be female and had higher rates of icu admission and in-hospital mortality. | journal of clinical medicine | eng | 2024 | Nov | Uzer Fatih, Karaboğa Burcu, Calis Aliye Gamze, Kaplan Nermin, Altınöz Emsal Sema, Sahin Sena, Karaca Mustafa | department of respiratory diseases, akdeniz university, 07070 antalya, türkiye., department of respiratory diseases, antalya ataturk state hospital, 07070 antalya, türkiye., department of respiratory diseases, university of health sciences antalya training and research hospital, 07070 antalya, türkiye., department of respiratory diseases, antalya ataturk state hospital, 07070 antalya, türkiye., department of respiratory diseases, akdeniz university, 07070 antalya, türkiye., department of respiratory diseases, akdeniz university, 07070 antalya, türkiye., department of medical oncology, akdeniz university, 07070 antalya, türkiye. | journal of clinical medicine | j clin med | 2077-0383 | 3.0 | 3.4 | MEDICINE, GENERAL & INTERNAL|Q1|58/325 | akdeniz university, department of respiratory diseases, antalya ataturk state hospital, university of health sciences antalya training and research hospital, antalya ataturk state hospital, akdeniz university, akdeniz university, akdeniz university | multicenter | akdeniz university | 1001–1200 | 27.3 | 1100.5 | Low (0-50) | |
| 74 | 73 | bridging the gap between tolerogenic dendritic cells in vitro and in vivo: analysis of siglec genes and pathways associated with immune modulation and evasion. | dendritic cells (dcs) are master regulators of the adaptive immune response. inflammatory dcs (inflamdcs) can prime inflammatory t cells in, for instance, cancer and infection. in contrast, tolerogenic dcs (toldcs) can suppress the immune system through a plethora of regulatory mechanisms in the context of autoimmunity. we successfully generated toldcs in vitro to durably restore immune tolerance to an islet autoantigen in type 1 diabetes patients in a clinical trial. however, cancers can induce inhibitory dcs in vivo that impair anti-tumor immunity through siglec signaling. | genes | eng | 2024 | Oct | Jansen Diahann T S L, Nikolic Tatjana, den Hollander Nicoline H M, Zwaginga Jaap Jan, Roep Bart O | department of internal medicine, leiden university medical center, 2333 za leiden, the netherlands., department of internal medicine, leiden university medical center, 2333 za leiden, the netherlands., department of internal medicine, leiden university medical center, 2333 za leiden, the netherlands., department of internal medicine, leiden university medical center, 2333 za leiden, the netherlands., department of internal medicine, leiden university medical center, 2333 za leiden, the netherlands. | genes | genes-basel | 2073-4425 | 2.8 | 3.3 | GENETICS & HEREDITY|Q2|85/191 | department of internal medicine, leiden university medical center, department of internal medicine, leiden university medical center, department of internal medicine, leiden university medical center, department of internal medicine, leiden university medical center, department of internal medicine, leiden university medical center | clinical trial | leiden university | 77 | 62.7 | 77.0 | Medium (50-75) | |
| 75 | 74 | resistance exercise improves glycolipid metabolism and mitochondrial biogenesis in skeletal muscle of t2dm mice via mir-30d-5p/sirt1/pgc-1α axis. | exercise is a recognized non-pharmacological treatment for improving glucose homeostasis in type 2 diabetes (t2dm), with resistance exercise (re) showing promising results. however, the mechanism of re improving t2dm has not been clarified. this study aims to investigate the effects of re on glucose and lipid metabolism, insulin signaling, and mitochondrial function in t2dm mice, with a focus on the regulatory role of mir-30d-5p. our results confirmed that re significantly improved fasting blood glucose, ipgtt, and itt in t2dm mice. enhanced expression of irs-1, p-pi3k, and p-akt indicated improved insulin signaling. re improved glycolipid metabolism, as well as mitochondrial biogenesis and dynamics in skeletal muscle of t2dm mice. we also found that mir-30d-5p was upregulated in t2dm, and was downregulated after re. additionally, in vitro, over-expression of mir-30d-5p significantly increased lipid deposition, and reduced glucose uptake and mitochondrial biogenesis. these observations were reversed after transfection with the mir-30d-5p inhibitor. mechanistically, mir-30d-5p regulates glycolipid metabolism in skeletal muscle by directly targeting sirt1, which affects the expression of pgc-1α, thereby influencing mitochondrial function and glycolipid metabolism. taken together, re effectively improves glucose and lipid metabolism and mitochondrial function in t2dm mice, partly through regulating the mir-30d-5p/sirt1/pgc-1α axis. mir-30d-5p could serve as a potential therapeutic target for t2dm management. | international journal of molecular sciences | eng | 2024 | Nov | Zheng Lifang, Rao Zhijian, Wu Jiabin, Ma Xiaojie, Jiang Ziming, Xiao Weihua | college of physical education, shanghai university, shanghai 200444, china., college of physical education, shanghai normal university, shanghai 200234, china., shanghai key laboratory of human performance, shanghai university of sport, shanghai 200438, china., college of physical education, shanghai university, shanghai 200444, china., college of physical education, shanghai university, shanghai 200444, china., shanghai key laboratory of human performance, shanghai university of sport, shanghai 200438, china. | international journal of molecular sciences | int j mol sci | 1661-6596 | 1422-0067 | 4.9 | 5.6 | CHEMISTRY, MULTIDISCIPLINARY|Q2|67/230 | college of physical education, shanghai university, college of physical education, shanghai normal university, shanghai key laboratory of human performance, shanghai university of sport, college of physical education, shanghai university, college of physical education, shanghai university, shanghai key laboratory of human performance, shanghai university of sport | re | shanghai university | 501–600 | 38.0 | 550.5 | Low (0-50) |
| 76 | 75 | <i>socs3</i> methylation partially mediated the association of exposure to triclosan but not triclocarban with type 2 diabetes mellitus: a case-control study. | this study aimed to evaluate the association of tcs (triclosan (tcs) and triclocarban) exposure with t2dm and glucose metabolism-related indicators and the mediating effect of <i>socs3</i> methylation on their associations. a total of 956 participants (330 t2dm and 626 controls) were included in this case-control study. logistic regression and generalized linear models were used to assess the effect of tcs on t2dm and glucose metabolism-related indicators. the dose-response relationship between tcs and t2dm was analyzed by restricted cubic spline. finally, after evaluating the association between tcs and <i>socs3</i> methylation levels, the mediating effect of <i>socs3</i> methylation on the tc-associated t2dm was estimated. each 1-unit increase in tcs levels was associated with a 13.2% increase in the risk of t2dm (or = 1.132, 95% ci: 1.062, 1.207). a linear dose-response relationship was found between tcs and t2dm. tcs was negatively associated with <i>chr17:76356190</i> methylation. moreover, mediation analysis revealed that <i>chr17:76356190</i> methylation mediated 14.54% of the relationship between tcs exposure and t2dm. exposure to tcs was associated with a higher prevalence of t2dm. <i>socs3</i> methylation partially mediated the association of tcs with t2dm. our findings may provide new insights into the treatment of t2dm, and the study of the biological mechanisms of t2dm. | international journal of molecular sciences | eng | 2024 | Nov | Gao Qian, Huan Changsheng, Jia Zexin, Cao Qingqing, Yuan Pengcheng, Li Xin, Wang Chongjian, Mao Zhenxing, Huo Wenqian | department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china., department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china., department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china., department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china., department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china., department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china., department of epidemiology and biostatistics, college of public health, zhengzhou university, zhengzhou 450001, china., department of epidemiology and biostatistics, college of public health, zhengzhou university, zhengzhou 450001, china., department of occupational and environmental health, college of public health, zhengzhou university, 100 kexue avenue, zhengzhou 450001, china. | international journal of molecular sciences | int j mol sci | 1661-6596 | 1422-0067 | 4.9 | 5.6 | CHEMISTRY, MULTIDISCIPLINARY|Q2|67/230 | college of public health, zhengzhou university, department of occupational and environmental health, college of public health, zhengzhou university, department of occupational and environmental health, college of public health, zhengzhou university, department of occupational and environmental health, college of public health, zhengzhou university, department of occupational and environmental health, college of public health, zhengzhou university, department of occupational and environmental health, college of public health, zhengzhou university, college of public health, zhengzhou university, college of public health, zhengzhou university, department of occupational and environmental health, college of public health, zhengzhou university | case-control study | zhengzhou university | 601–800 | 19.8 | 700.5 | Low (0-50) |
| 77 | 76 | caffeine: a multifunctional efficacious molecule with diverse health implications and emerging delivery systems. | natural caffeine is found in many plants, including coffee beans, cacao beans, and tea leaves. around the world, many beverages, including coffee, tea, energy drinks, and some soft drinks, have this natural caffeine compound. this paper reviewed the results of meta-studies on caffeine's effects on chronic diseases. of importance, many meta-studies have shown that regularly drinking caffeine or caffeinated coffee significantly reduces the risk of developing alzheimer's disease, epilepsy, and parkinson's disease. based on the health supplements of caffeine, this review summarizes various aspects related to the application of caffeine, including its pharmacokinetics, and various functional health benefits of caffeine, such as its effects on the central nervous system. the importance of caffeine and its use in alleviating or treating cancer, diabetes, eye diseases, autoimmune diseases, and cardiovascular diseases is also discussed. overall, consuming caffeine daily in drinks containing antioxidant and neuroprotective properties, such as coffee, prevents progressive neurodegenerative diseases, such as alzheimer's and parkinson's. furthermore, to effectively deliver caffeine to the body, recently developed nanoformulations using caffeine, for instance, nanoparticles, liposomes, etc., are summarized along with regulatory and safety considerations for caffeine. the u.s. department of agriculture (usda) and the food and drug administration (fda) recommended that healthy adults consume up to 400 mg of caffeine per day or 5~6 mg/kg body weight. since a cup of coffee contains, on average, 100 to 150 mg of coffee, 1 to 3 cups of coffee may help prevent chronic diseases. furthermore, this review summarizes various interesting and important areas of research on caffeine and its applications related to human health. | international journal of molecular sciences | eng | 2024 | Nov | Song Xinjie, Singh Mahendra, Lee Kyung Eun, Vinayagam Ramachandran, Kang Sang Gu | zhejiang provincial key lab for chemical and biological processing technology of farm product, school of biological and chemical engineering, zhejiang university of science and technology, hangzhou 310023, china., department of biotechnology, institute of biotechnology, school of life and applied sciences, yeungnam university, gyeongsan 38541, republic of korea., sunforce inc., 208-31, gumchang-ro, yeungcheon-si 31882, republic of korea., department of biotechnology, institute of biotechnology, school of life and applied sciences, yeungnam university, gyeongsan 38541, republic of korea., department of biotechnology, institute of biotechnology, school of life and applied sciences, yeungnam university, gyeongsan 38541, republic of korea. | international journal of molecular sciences | int j mol sci | 1661-6596 | 1422-0067 | 4.9 | 5.6 | CHEMISTRY, MULTIDISCIPLINARY|Q2|67/230 | school of biological and chemical engineering, zhejiang university of science and technology, department of biotechnology, institute of biotechnology, school of life and applied sciences, yeungnam university, sunforce inc., department of biotechnology, institute of biotechnology, school of life and applied sciences, yeungnam university, department of biotechnology, institute of biotechnology, school of life and applied sciences, yeungnam university | meta-studies | zhejiang university | 55 | 75.3 | 55.0 | High (75-100) |
| 78 | 77 | modulators of alpha-2 macroglobulin upregulation by high glucose in glomerular mesangial cells. | up to 40% of patients with diabetes mellitus will develop diabetic kidney disease (dkd), characterized pathologically by the accumulation of extracellular matrix proteins, which leads to the loss of kidney function over time. our previous studies showed that the pan-protease inhibitor alpha 2-macroglobulin (a2m) is increased in dkd and is a critical regulator of the fibrotic response in glomerular mesangial cells (mc), an initial site of injury during dkd development. how a2m is regulated by high glucose (hg) has not yet been elucidated and is the focus of this investigation. using serial deletions of the full a2m promoter, we identified the -405 bp region as hg-responsive in mc. site-directed mutagenesis, sirna, and chip studies showed that the transcription factor, nuclear factor of activated t cells 5 (nfat5), regulated a2m promoter activity and protein expression in response to hg. forkhead box p1 (foxp1) served as a cooperative binding partner for nfat5, required for a2m upregulation. lastly, we showed that smad3, known for its role in kidney fibrosis, regulated a2m promoter activity and protein production independently of hg. the importance of nfat5, foxp1, and smad3 in a2m regulation was confirmed in ex vivo studies using isolated glomeruli. in conclusion, smad3 is required for basal and hg-induced a2m expression, while nfat5 and foxp1 cooperatively regulate increased a2m transcription in response to hg. inhibition of nfat5/foxp1 will be further evaluated as a potential therapeutic strategy to inhibit a2m production and attenuate profibrotic signaling in dkd. | biomolecules | eng | 2024 | Nov | Trink Jackie, Li Renzhong, Gao Bo, Lu Chao, Krepinsky Joan C | division of nephrology, mcmaster university, hamilton, on l8n 1y3, canada., division of nephrology, mcmaster university, hamilton, on l8n 1y3, canada., division of nephrology, mcmaster university, hamilton, on l8n 1y3, canada., division of nephrology, mcmaster university, hamilton, on l8n 1y3, canada., division of nephrology, mcmaster university, hamilton, on l8n 1y3, canada. | biomolecules | biomolecules | 2218-273X | 4.8 | 5.4 | BIOCHEMISTRY & MOLECULAR BIOLOGY|Q1|67/313 | division of nephrology, mcmaster university, division of nephrology, mcmaster university, division of nephrology, mcmaster university, division of nephrology, mcmaster university, division of nephrology, mcmaster university | site-directed mutagenesis | mcmaster university | 103 | 51.3 | 103.0 | Medium (50-75) | |
| 79 | 78 | alterations in the levels of urinary exosomal microrna-183-5p and microrna-125a-5p in individuals with type 2 diabetes mellitus. | <b>background:</b> type 2 diabetes mellitus (t2dm) is a metabolic disorder, and urinary exosomal micrornas (mirnas) were utilized as potential disease prediction or diagnostic biomarkers in numerous studies. this study investigated the differential expression of urinary exosomal mirnas between non-diabetes mellitus (ndm) individuals and those with t2dm. <b>aim:</b> to elucidate the association between urinary exosomal mirnas and t2dm. <b>methods</b>: we recruited patients diagnosed with t2dm and ndm individuals in west china hospital, sichuan university, from november 2023 to february 2024. subsequently, we performed sequencing of urinary exosomal micrornas in both groups. the obtained sequencing results were further validated using rt-qpcr in both the training set and the validation set. additionally, we conducted logistic regression analysis and spearman correlation analysis on mirnas with significant differential expression, as well as analysis of their biological functions. <b>results</b>: a total of 118 urine samples were collected, 59 from individuals diagnosed with t2dm and 59 from ndm. there were differentially expressed mir-183-5p (<i>p</i> = 0.034) and mir-125a-5p (<i>p</i> = 0.008) between the two groups. furthermore, multivariate regression analysis demonstrated that higher mir-125a-5p levels were negatively associated with the risk of t2dm (<i>p</i> = 0.044; or: 0.046; 95% ci: 0.002, 0.922). bioinformatics analysis indicated that the target genes of mir-183-5p were predominantly involved in insulin signaling and glucose transport processes, while those target genes of mir-125a-5p primarily mediated autophagy. <b>conclusions</b>: mir-183-5p and mir-125a-5p might be involved in the pathogenesis of t2dm, while higher urinary exosomal mir-125a-5p was negatively associated with the risk of t2dm. | biomedicines | eng | 2024 | Nov | Fang Yixuan, Sun Shiyi, Wu Jing, Liu Guanjian, Wu Qinqin, Ran Xingwu | innovation research center for diabetic foot, diabetic foot care center, department of endocrinology & metabolism, west china hospital, sichuan university, chengdu 610041, china., innovation research center for diabetic foot, diabetic foot care center, department of endocrinology & metabolism, west china hospital, sichuan university, chengdu 610041, china., innovation research center for diabetic foot, diabetic foot care center, department of endocrinology & metabolism, west china hospital, sichuan university, chengdu 610041, china., chinese cochrane centre, west china hospital, sichuan university, chengdu 610041, china., health management center, general practice center, west china hospital, sichuan university, chengdu 610041, china., innovation research center for diabetic foot, diabetic foot care center, department of endocrinology & metabolism, west china hospital, sichuan university, chengdu 610041, china. | biomedicines | biomedicines | 2227-9059 | 3.9 | 4.1 | PHARMACOLOGY & PHARMACY|Q1|85/354 | department of endocrinology & metabolism, west china hospital, sichuan university, department of endocrinology & metabolism, west china hospital, sichuan university, department of endocrinology & metabolism, west china hospital, sichuan university, west china hospital, sichuan university, west china hospital, sichuan university, department of endocrinology & metabolism, west china hospital, sichuan university | Unknown | sichuan university | 150 | 57.3 | 150.0 | Medium (50-75) | |
| 80 | 79 | characterizing fibroblast heterogeneity in diabetic wounds through single-cell rna-sequencing. | diabetes mellitus is an increasingly prevalent chronic metabolic disorder characterized by physiologic hyperglycemia that, when left uncontrolled, can lead to significant complications in multiple organs. diabetic wounds are common in the general population, yet the underlying mechanism of impaired healing in such wounds remains unclear. single-cell rna-sequencing (scrnaseq) has recently emerged as a tool to study the gene expression of heterogeneous cell populations in skin wounds. herein, we review the history of scrnaseq and its application to the study of diabetic wound healing, focusing on how innovations in single-cell sequencing have transformed strategies for fibroblast analysis. we summarize recent research on the role of fibroblasts in diabetic wound healing and describe the functional and cellular heterogeneity of skin fibroblasts. moreover, we highlight future opportunities in diabetic wound fibroblast research, with a focus on characterizing distinct fibroblast subpopulations and their lineages. leveraging single-cell technologies to explore fibroblast heterogeneity and the complex biology of diabetic wounds may reveal new therapeutic targets for improving wound healing and ultimately alleviate the clinical burden of chronic wounds. | biomedicines | eng | 2024 | Nov | Wang Helen H, Korah Maria, Jing Serena L, Berry Charlotte E, Griffin Michelle F, Longaker Michael T, Januszyk Michael | hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa., hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa., hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa., hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa., hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa., hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa., hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, stanford, ca 94305, usa. | biomedicines | biomedicines | 2227-9059 | 3.9 | 4.1 | PHARMACOLOGY & PHARMACY|Q1|85/354 | hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine, hagey laboratory for pediatric regenerative medicine, stanford university school of medicine, hagey laboratory for pediatric regenerative medicine, stanford university school of medicine, hagey laboratory for pediatric regenerative medicine, stanford university school of medicine, hagey laboratory for pediatric regenerative medicine, stanford university school of medicine, hagey laboratory for pediatric regenerative medicine, stanford university school of medicine, hagey laboratory for pediatric regenerative medicine, division of plastic and reconstructive surgery, stanford university school of medicine | Unknown | stanford university | 2 | 97.8 | 2.0 | High (75-100) | |
| 81 | 80 | material technologies for improved diabetic foot ulcer (dfu) treatment: a questionnaire study of healthcare professionals' needs. | <b>background/objectives:</b> diabetic foot ulcers (dfus) are a common and severe complication of diabetic patients, with significant global prevalence and associated health burdens, including high recurrence rates, lower-limb amputations, and substantial associated economic costs. this study aimed to understand the user needs of healthcare professionals treating diabetic foot ulcers for newly developed material technologies. <b>methods:</b> an open-ended questionnaire was used to identify user needs, identify the limitations of current treatments, and determine the specific requirements for ideal treatment. this information was used to develop a list of key considerations for creating innovative material technologies to improve diabetic wound treatment results. <b>results:</b> most respondents indicated that they followed published treatment guidelines for dfus but noted that treatment often required a case-specific approach. antibiotics and surgical debridement were commonly used for infection control. the participants showed a strong preference for wound dressings with lasting antibacterial properties. respondents identified ideal properties for new products, including ease of use, enhanced antibacterial properties, affordability, and targeted biological activity. the respondents also highlighted the importance of a holistic approach to dfu management, integrating product development with comprehensive care strategies and patient education. <b>conclusions:</b> this study highlights the complexity of dfu care, emphasizing that no single product can address all treatment needs. future materials could focus on combination therapies and specific use cases. additionally, understanding global variations in treatment practices and educating users on the proper application of newly developed material technologies is crucial for improving the management of dfus and patient outcomes. | biomedicines | eng | 2024 | Oct | Vargas Guerrero Marian Gabriela, Vonken Lieve, Peters Erwin, Lucchesi Jimmy, Arts Jacobus J C | department of orthopaedic surgery, maastricht university medical centre (mumc+), 6229 hx maastricht, the netherlands., department of health promotion, faculty of health, medicine & life sciences, maastricht university, 6229 ha maastricht, the netherlands., department of orthopaedic surgery, maastricht university medical centre (mumc+), 6229 hx maastricht, the netherlands., bonalive biomaterials, 20750 turku, finland., department of orthopaedic surgery, maastricht university medical centre (mumc+), 6229 hx maastricht, the netherlands. | biomedicines | biomedicines | 2227-9059 | 3.9 | 4.1 | PHARMACOLOGY & PHARMACY|Q1|85/354 | department of orthopaedic surgery, maastricht university, department of health promotion, faculty of health, medicine & life sciences, maastricht university, department of orthopaedic surgery, maastricht university, bonalive biomaterials, department of orthopaedic surgery, maastricht university | Unknown | maastricht university | 138 | 47.1 | 138.0 | Low (0-50) | |
| 82 | 81 | hippocampal leptin resistance and cognitive decline: mechanisms, therapeutic strategies and clinical implications. | <b>background:</b> leptin, an adipokine essential for regulating energy balance, exerts important effects on brain function, notably within the hippocampus, a region integral to learning and memory. leptin resistance, characterized by diminished responsiveness to elevated leptin levels, disrupts hippocampal function and exacerbates both obesity and cognitive impairments. <b>scope:</b> this review critically examines how leptin resistance impairs hippocampal synaptic plasticity processes, specifically affecting long-term potentiation (ltp) and long-term depression (ltd), which are crucial for cognitive performance. <b>findings:</b> recent research highlights that leptin resistance disrupts n-methyl-d-aspartate (nmda) receptor dynamics and hippocampal structure, leading to deficits in spatial learning and memory. additionally, high-fat diets (hfds), which contribute to leptin resistance, further deteriorate hippocampal function. potential therapeutic strategies, including leptin sensitizers, show promise in mitigating brain disorders associated with leptin resistance. complementary interventions such as caloric restriction and physical exercise also enhance leptin sensitivity and offer potential benefits to alleviating cognitive impairments. <b>aims of the review:</b> this review synthesizes recent findings on the molecular pathways underlying leptin resistance and its impact on synaptic transmission and plasticity in the hippocampus. by identifying potential therapeutic targets, this work aims to provide an integrated approach for addressing cognitive deficits in obesity, ultimately improving the quality of life for affected individuals. | biomedicines | eng | 2024 | Oct | Valladolid-Acebes Ismael | the rolf luft research center for diabetes and endocrinology, karolinska institutet, karolinska university hospital l1, se-171 76 stockholm, sweden. | biomedicines | biomedicines | 2227-9059 | 3.9 | 4.1 | PHARMACOLOGY & PHARMACY|Q1|85/354 | karolinska institutet, karolinska university hospital | Unknown | karolinska institute | 50 | 67.9 | 50.0 | Medium (50-75) | |
| 83 | 82 | targeting glucose metabolism: a novel therapeutic approach for parkinson's disease. | glucose metabolism is essential for the maintenance and function of the central nervous system. although the brain constitutes only 2% of the body weight, it consumes approximately 20% of the body's total energy, predominantly derived from glucose. this high energy demand of the brain underscores its reliance on glucose to fuel various functions, including neuronal activity, synaptic transmission, and the maintenance of ion gradients necessary for nerve impulse transmission. increasing evidence shows that many neurodegenerative diseases, including parkinson's disease (pd), are associated with abnormalities in glucose metabolism. pd is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, accompanied by the accumulation of α-synuclein protein aggregates. these pathological features are exacerbated by mitochondrial dysfunction, oxidative stress, and neuroinflammation, all of which are influenced by glucose metabolism disruptions. emerging evidence suggests that targeting glucose metabolism could offer therapeutic benefits for pd. several antidiabetic drugs have shown promise in animal models and clinical trials for mitigating the symptoms and progression of pd. this review explores the current understanding of the association between pd and glucose metabolism, emphasizing the potential of antidiabetic medications as a novel therapeutic approach. by improving glucose uptake and utilization, enhancing mitochondrial function, and reducing neuroinflammation, these drugs could address key pathophysiological mechanisms in pd, offering hope for more effective management of this debilitating disease. | cells | eng | 2024 | Nov | Tanvir Ahmed, Jo Junghyun, Park Sang Myun | department of pharmacology, ajou university school of medicine, suwon 16499, republic of korea., department of pharmacology, ajou university school of medicine, suwon 16499, republic of korea., department of pharmacology, ajou university school of medicine, suwon 16499, republic of korea. | cells | cells-basel | 2073-4409 | 5.1 | 6.0 | CELL BIOLOGY|Q2|63/205 | ajou university school of medicine, republic of korea, ajou university school of medicine, republic of korea, ajou university school of medicine, republic of korea | animal models | ajou university | 501–600 | 37.7 | 550.5 | Low (0-50) | |
| 84 | 83 | does incretin agonism have sustainable efficacy? | recent clinical trials using synthetic incretin hormones, glucagon-like peptide 1 (glp-1), and glucose-dependent insulinotropic polypeptide (gip) receptor agonists have demonstrated that these treatments ameliorated many complications related to obesity, emphasizing the significant impact of body weight on overall health. incretins are enteroendocrine hormones secreted by gut endothelial cells triggered by nutrient ingestion. the phenomenon that oral ingestion of glucose elicits a much higher insulin secretion than intra-venous injection of equimolar glucose is known as the incretin effect. this also alludes to the thesis that food intake is the root cause of insulin resistance. synthetic glp-1 and gip agonists have demonstrated unprecedented glucoregulation and body weight reduction. also, randomized trials have shown their ability to prevent complications of obesity, including development of diabetes from prediabetes, reducing cardiovascular disease risks and renal complications in diabetic patients. moreover, the benefits of these agonists persist among the patients who are already on metformin or insulin. the ultimate question is "are these benefits of incretin agonism sustainable?" chronic agonism of pancreatic β-cells may decrease the number of receptors and cause β-cell exhaustion, leading to β-cell failure. unfortunately, the long-term effects of these drugs are unknown at the present because the longest duration in randomized trials is 3 years. additionally, manipulation of the neurohormonal axis to control satiety and food intake may hinder the long-term sustainability of these treatments. in this review, we will discuss the incretins' mechanism of action, challenges, and future directions. we will briefly review other molecules involved in glucose homeostasis such as amylin and glucagon. amylin is co-expressed with insulin from the pancreas β-cells but does not have insulinotropic function. amylin suppresses glucagon secretion, slowing gastric emptying and suppressing the reward center in the central nervous system, leading to weight loss. however, amylin can self-aggregate and cause serious cytotoxicity and may cause β-cell apoptosis. glucagon is secreted by pancreatic α-cells and participates in glucose homeostasis in a glucose-dependent manner. in hypoglycemia, glucagon increases the blood glucose level by glycogenolysis and gluconeogenesis and inhibits glycogenesis in the liver. several triple agonists, in combination with dual incretins and glucagon, are being developed. | cells | eng | 2024 | Nov | Janket Sok-Ja, Chatanaka Miyo K, Sohaei Dorsa, Tamimi Faleh, Meurman Jukka H, Diamandis Eleftherios P | retired research associate professor, boston university goldman school of dental medicine, boston, ma 02118, usa., department of laboratory medicine and pathobiology, university of toronto, toronto, on m5s 1a8, canada., m.d., c.m. candidate 2026, faculty of medicine and health sciences, mcgill university, montreal, qc h4a qt2, canada., department of restorative dentistry, college of dental medicine, qatar university, doha p.o. box 2713, qatar., department of oral and maxillofacial diseases, helsinki university hospital and university of helsinki, fi-00290 helsinki, finland., lunenfeld-tanenbaum research institute, sinai health system, toronto, on m5t 3l9, canada. | cells | cells-basel | 2073-4409 | 5.1 | 6.0 | CELL BIOLOGY|Q2|63/205 | boston university, goldman school of dental medicine, university of toronto, mcgill university, college of dental medicine, qatar university, helsinki university hospital, university of helsinki, lunenfeld-tanenbaum research institute, sinai health system | clinical trials | boston university | 78 | 54.1 | 78.0 | Medium (50-75) | |
| 85 | 84 | new insights into fgf21 alleviates diabetic cardiomyopathy by suppressing ferroptosis: a commentary. | diabetic cardiomyopathy (dcm) is a severe cardiovascular complication of diabetes characterized by myocardial hypertrophy, fibrosis, and impaired cardiac function. fibroblast growth factor 21 (fgf21) has emerged as a promising therapeutic target due to its antifibrotic, antioxidant, and anti-inflammatory properties. our commentary summarizes and affirms the recent study by wang et al., which demonstrates the significant role of ferroptosis in dcm pathogenesis. fgf21 has shown promise as a therapeutic target for dcm, potentially inhibiting ferroptosis, mitigating oxidative damage, and protecting cardiomyocyte function. mechanistically, the study identified atf4 as an upstream regulator of fgf21 in dcm, revealing that fgf21 directly interacts with ferritin and extends its half-life, thus inhibiting ferroptosis in dcm. these findings provide a theoretical basis for understanding the pathogenesis and treatment of dcm. our commentary suggests that future studies should explore the role of non-cardiomyocyte cell types in dcm, verify findings with clinical samples, and address comprehensive methods for ferroptosis detection. additionally, we discuss the clinical application and future potential of fgf21-based therapies for dcm. such efforts may contribute to advancing dcm diagnosis and treatment, fostering the development of innovative therapeutic strategies. | cardiovascular diabetology | eng | 2024 | Nov | Chen Kexin, Wang Si | department of cardiology, west china hospital, sichuan university, chengdu, 610041, people's republic of china., department of cardiology, west china hospital, sichuan university, chengdu, 610041, people's republic of china. si.wang@scu.edu.cn. | cardiovascular diabetology | cardiovasc diabetol | 1475-2840 | 8.5 | 8.9 | ENDOCRINOLOGY & METABOLISM|Q1|11/186 | west china hospital, sichuan university, people's republic of china, west china hospital, sichuan university, people's republic of china | future studies | sichuan university | 150 | 57.3 | 150.0 | Medium (50-75) | |
| 86 | 85 | the association between ozone exposure and blood pressure in a general chinese middle-aged and older population: a large-scale repeated-measurement study. | the relationship between ozone (o<sub>3</sub>) exposure and blood pressure (bp) remains inconclusive. given the scarcity of chinese epidemiological data, more research on this association is of paramount importance, particularly among middle-aged and older chinese populations. | bmc medicine | eng | 2024 | Nov | Tang Chen, Zhang Yiqin, Yi Jingping, Lu Zhonghua, Xuan Xianfa, Jiang Hanxiang, Guo Dongbei, Xiang Hanyu, Wu Ting, Yan Jianhua, Zhang Siyu, Wang Yuxin, Zhang Jie | state key laboratory of vaccines for infectious diseases, xiang an biomedicine laboratory, state key laboratory of molecular vaccinology and molecular diagnostics, school of public health, national innovation platform for industry-education integration in vaccine research, xiamen university, xiamen, fujian, china., department of nephrology, the second affiliated hospital of xiamen medical college, xiamen, fujian, china., zhoushan municipal center for disease control and prevention, zhoushan, zhejiang, china., state key laboratory of vaccines for infectious diseases, xiang an biomedicine laboratory, state key laboratory of molecular vaccinology and molecular diagnostics, school of public health, national innovation platform for industry-education integration in vaccine research, xiamen university, xiamen, fujian, china., department of nephrology, the second affiliated hospital of xiamen medical college, xiamen, fujian, china., xiamen guankou hospital, xiamen, fujian, china., state key laboratory of vaccines for infectious diseases, xiang an biomedicine laboratory, state key laboratory of molecular vaccinology and molecular diagnostics, school of public health, national innovation platform for industry-education integration in vaccine research, xiamen university, xiamen, fujian, china., state key laboratory of vaccines for infectious diseases, xiang an biomedicine laboratory, state key laboratory of molecular vaccinology and molecular diagnostics, school of public health, national innovation platform for industry-education integration in vaccine research, xiamen university, xiamen, fujian, china., department of nephrology, the second affiliated hospital of xiamen medical college, xiamen, fujian, china., department of nephrology, the second affiliated hospital of xiamen medical college, xiamen, fujian, china., department of nephrology, the second affiliated hospital of xiamen medical college, xiamen, fujian, china., department of nephrology, the second affiliated hospital of xiamen medical college, xiamen, fujian, china. wyx1000@126.com., state key laboratory of vaccines for infectious diseases, xiang an biomedicine laboratory, state key laboratory of molecular vaccinology and molecular diagnostics, school of public health, national innovation platform for industry-education integration in vaccine research, xiamen university, xiamen, fujian, china. jie.zhang@xmu.edu.cn. | bmc medicine | bmc med | 1741-7015 | 1741-7015 | 7.0 | 8.7 | MEDICINE, GENERAL & INTERNAL|Q1|23/325 | school of public health, xiamen university, department of nephrology, xiamen medical college, zhoushan municipal center for disease control and prevention, school of public health, xiamen university, department of nephrology, xiamen medical college, xiamen guankou hospital, school of public health, xiamen university, school of public health, xiamen university, department of nephrology, xiamen medical college, department of nephrology, xiamen medical college, department of nephrology, xiamen medical college, department of nephrology, xiamen medical college, school of public health | Unknown | xiamen university | 301–350 | 33.5 | 325.5 | Low (0-50) |
| 87 | 86 | estimating the cost of chronic kidney disease in australia. | chronic kidney disease (ckd) is a significant burden on health systems globally, with limited up-to-date information on health system costs, particularly for non-dialysis patients. this study estimates the direct healthcare costs of ckd within australia. | bmc health services research | eng | 2024 | Nov | Randall Sean, Lee Crystal M Y, Thomas Elizabeth, Chakera Aron, Chai Kevin E K, Varhol Richard, Mehta Kanika, Irish Ashley, Conradie Johan, Hadlow Narelle, Hendrie Delia, Boyd James H, Robinson Suzanne | deakin health economics, institute for health transformation, deakin university, burwood hwy, burwood, vic, 3125, australia. s.randall@deakin.edu.au., school of population health, curtin university, perth, wa, australia., school of population health, curtin university, perth, wa, australia., sir charles gairdner hospital, nedlands, wa, australia., school of population health, curtin university, perth, wa, australia., school of population health, curtin university, perth, wa, australia., baker heart and diabetes institute, victoria, australia., wa country health service, perth, wa, australia., western diagnostic pathology, perth, wa, australia., pathwest laboratory medicine, perth, wa, australia., school of population health, curtin university, perth, wa, australia., department of public health, la trobe university, victoria, australia., deakin health economics, institute for health transformation, deakin university, burwood hwy, burwood, vic, 3125, australia. | bmc health services research | bmc health serv res | 1472-6963 | 2.7 | 3.1 | HEALTH CARE SCIENCES & SERVICES|Q2|60/174 | institute for health transformation, deakin university, curtin university, school of population health, curtin university, sir charles gairdner hospital, school of population health, curtin university, school of population health, curtin university, baker heart and diabetes institute, wa country health service, western diagnostic pathology, pathwest laboratory medicine, school of population health, curtin university, department of public health, la trobe university, institute for health transformation, deakin university | Unknown | deakin university | 251–300 | 34.6 | 275.5 | Low (0-50) | |
| 88 | 87 | discontinuation and reinitiation of mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction. | mineralocorticoid receptor antagonists (mra) improve outcomes in heart failure with reduced ejection fraction (hfref) but are underused. point prevalent use has been described, but the kinetics of discontinuation and the extent of reinitiation have not been studied. | european journal of heart failure | eng | 2024 | Nov | Landucci Laura, Faxén Ulrika Ljung, Benson Lina, Dahlström Ulf, Carrero Juan J, Savarese Gianluigi, Lund Lars H | division of cardiology, department of medicine, karolinska institutet, stockholm, sweden., division of cardiology, department of medicine, karolinska institutet, stockholm, sweden., division of cardiology, department of medicine, karolinska institutet, stockholm, sweden., department of cardiology and health, medicine and caring sciences, linkoping university, linkoping, sweden., department of medical epidemiology and biostatistics, karolinska institutet, stockholm, sweden., division of cardiology, department of medicine, karolinska institutet, stockholm, sweden., division of cardiology, department of medicine, karolinska institutet, stockholm, sweden. | european journal of heart failure | eur j heart fail | 1388-9842 | 1879-0844 | 16.9 | 16.2 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q1|5/220 | division of cardiology, department of medicine, karolinska institutet, division of cardiology, department of medicine, karolinska institutet, division of cardiology, department of medicine, karolinska institutet, department of cardiology, linkoping university, karolinska institutet, division of cardiology, department of medicine, karolinska institutet, division of cardiology, department of medicine, karolinska institutet | point prevalent use | karolinska institute | 50 | 67.9 | 50.0 | Medium (50-75) |
| 89 | 88 | investigating the potential role of t helper 17 cells among women experiencing overweight and obesity and their possible therapeutic targeting of the rorγt molecule. | obesity is a growing healthcare problem globally. in saudi arabia, 24% of adults aged 15 years and above have been living with obesity. it is considered a chronic inflammatory condition that is linked to a wide range of disorders including type 2 diabetes mellitus, insulin resistance and cardiovascular diseases. in this study, we aimed to assess the influence of obesity on the proportion of th17 cells among healthy, overweight, and obese women in saudi arabia. additionally, we aimed to explore potential ligands targeting the master transcription factor of th17 cells: rorγt. a cross-sectional study was conducted, wherein their body mass index (bmi) and waist circumference (wc) were measured. the proportion of peripheral th17 cells was determined using flow cytometry. we found a decrease in the proportion of peripheral th17 among women with central obesity, though this was observed among overweight and obese participants. interestingly, both bmi and wc were inversely correlated with the proportion of peripheral th17 cells in women experiencing overweight or obesity, while no change was observed among healthy participants. notably, the analysis revealed a significant moderate negative correlation between the proportion of th17 cells and hba1c levels, observed only among the overweight and obese participants. in this study, we identified three potential binding sites on rorγt molecules of th17 cells, bound to 58 chemical ligands. the majority of the chemical structures (72.4%) were targeted binding pocket 1 of the rorγt molecule. these findings could provide a new insight to develop new pharmaceutical molecules targeting immune cells to combat obesity and related metabolic disorders. | scientific reports | eng | 2024 | Nov | Alhamawi Renad M, Damfo Shymaa, Aloufi Noof, Almutawif Yahya A, Suliman Bandar A | department of clinical laboratory sciences, college of applied medical sciences, taibah university, madinah, saudi arabia. rhamawi@taibahu.edu.sa., department of pharmacognosy and pharmaceutical chemistry, college of pharmacy, taibah university, madinah, saudi arabia., department of clinical laboratory sciences, college of applied medical sciences, taibah university, madinah, saudi arabia., department of clinical laboratory sciences, college of applied medical sciences, taibah university, madinah, saudi arabia., department of clinical laboratory sciences, college of applied medical sciences, taibah university, madinah, saudi arabia. | scientific reports | sci rep-uk | 2045-2322 | 2045-2322 | 3.8 | 4.3 | MULTIDISCIPLINARY SCIENCES|Q1|25/134 | college of applied medical sciences, taibah university, college of pharmacy, taibah university, college of applied medical sciences, taibah university, college of applied medical sciences, taibah university, college of applied medical sciences, taibah university | cross-sectional study | taibah university | 1001–1200 | 10.2 | 1100.5 | Low (0-50) |
| 90 | 89 | an overview on pharmaceutical applications of phosphodiesterase enzyme 5 (pde5) inhibitors. | phosphodiesterase enzyme 5 (pde5) inhibitors have emerged as one of the leading molecules for the treatment of erectile dysfunction (ed). pde5 inhibitors are categorized structurally into several classes. pde5 inhibitors have been a multidisciplinary endeavor that attracts the attention of researchers because of their multiple pharmaceutical applications. beyond their action on ed, pde5 inhibitors are widely used in treatment of benign prostatic hypertrophy (bph), eisenmenger's syndrome, raynaud's disease, intrauterine growth retardation (iugr), mountain sickness, bladder pain syndrome/interstitial cystitis (bps/ic), pulmonary arterial hypertension and type ii diabetes (insulin resistance). in addition, pde5 inhibitors also show promising antiproliferative activity, anti-alzheimer and cox-1/cox-2 inhibitory activity (anti-inflammatory). pharmacokinetics, pharmacogenetics and toxicity of pde5 inhibitors were finally explored. the diverse therapeutic applications, the high feasibility of structural modification and the appropriate pharmacokinetic properties of pde5 inhibitors have motivated researchers to develop new scaffolds that have been either under clinical trials or approved by fda and utilize them to overcome some recent global concerns, such as covid-19. | molecular diversity | eng | 2024 | Nov | Nemr Mohamed T M, Abdelaziz Mostafa A, Teleb Mohamed, Elmasry Ahmed E, Elshaier Yaseen A A M | pharmaceutical organic chemistry department, faculty of pharmacy, cairo university, kasr el-eini street 11562, cairo, egypt. mohamed.nemr@pharma.cu.edu.eg., department of chemistry, college of wooster, wooster, oh, 44691, usa., department of pharmaceutical chemistry, faculty of pharmacy, alexandria university, alexandria, 21521, egypt., organic & medicinal chemistry department, faculty of pharmacy, university of sadat city, menoufia, egypt., organic & medicinal chemistry department, faculty of pharmacy, university of sadat city, menoufia, egypt. yaseen.elshaier@fop.usc.edu.eg. | molecular diversity | mol divers | 1381-1991 | 1573-501X | 3.9 | 3.5 | CHEMISTRY, MULTIDISCIPLINARY|Q2|79/230 | faculty of pharmacy, cairo university, college of wooster, faculty of pharmacy, alexandria university, faculty of pharmacy, university of sadat city, faculty of pharmacy, university of sadat city | clinical trials | cairo university | 801–1000 | 18.5 | 900.5 | Low (0-50) |
| 91 | 90 | correction: quantifying beta cell function in the preclinical stages of type 1 diabetes. | no abstract | diabetologia | eng | 2024 | Nov | Galderisi Alfonso, Carr Alice L J, Martino Mariangela, Taylor Peter, Senior Peter, Dayan Colin | department of pediatrics, yale university, new haven, ct, usa., alberta diabetes institute, university of alberta, edmonton, ab, canada., division of infection and immunity, school of medicine, cardiff university, cardiff, uk., division of infection and immunity, school of medicine, cardiff university, cardiff, uk., alberta diabetes institute, university of alberta, edmonton, ab, canada., division of infection and immunity, school of medicine, cardiff university, cardiff, uk. dayancm@cardiff.ac.uk. | diabetologia | diabetologia | 0012-186X | 1432-0428 | 8.4 | 9.1 | ENDOCRINOLOGY & METABOLISM|Q1|12/186 | yale university, alberta diabetes institute, university of alberta, division of infection and immunity, school of medicine, cardiff university, division of infection and immunity, school of medicine, cardiff university, alberta diabetes institute, university of alberta, division of infection and immunity, school of medicine, cardiff university | Unknown | yale university | 10 | 94.9 | 10.0 | High (75-100) |
| 92 | 91 | the effects of modest intake of soy milk enriched with lactobacillus casei and omega-3 on the testis parameters in diabetic rats: a stereological study. | diabetes mellitus is a widely distributed endocrine disorder in the world. altered reproductive function is a notable long-term consequence of type 1 diabetes mellitus (t1dm). in the current study, we assessed the effects of soya milk containing lactobacillus casei and omega-3 on stereology of testes in type 1 diabetic rats. | international urology and nephrology | eng | 2024 | Nov | Bayat Maryam, Koohpeyma Farhad, Montazeri-Najafabady Nima, Dabbaghmanesh Mohammad Hossein, Asmarian Naeimehossadat, Hosseini Seyyed Iman | shiraz endocrinology and metabolism research center, shiraz university of medical sciences, p.o. box: 719363-5899, shiraz, iran., shiraz endocrinology and metabolism research center, shiraz university of medical sciences, p.o. box: 719363-5899, shiraz, iran. koohpeyma.f@sums.ac.ir., shiraz endocrinology and metabolism research center, shiraz university of medical sciences, p.o. box: 719363-5899, shiraz, iran., shiraz endocrinology and metabolism research center, shiraz university of medical sciences, p.o. box: 719363-5899, shiraz, iran., anesthesiology and critical care research center, shiraz university of medical sciences, shiraz, iran., shiraz endocrinology and metabolism research center, shiraz university of medical sciences, p.o. box: 719363-5899, shiraz, iran. | international urology and nephrology | int urol nephrol | 0301-1623 | 1573-2584 | 1.8 | 2.0 | UROLOGY & NEPHROLOGY|Q3|68/126 | shiraz university of medical sciences, shiraz endocrinology and metabolism research center, shiraz university of medical sciences, shiraz university of medical sciences, shiraz endocrinology and metabolism research center, shiraz university of medical sciences, shiraz university of medical sciences, shiraz endocrinology and metabolism research center, shiraz university of medical sciences | current study | shiraz university | 801–1000 | 24.6 | 900.5 | Low (0-50) |
| 93 | 92 | diabetic retinopathy and periodontitis: implications from a systematic review and meta-analysis. | diabetes mellitus, a chronic metabolic disorder affecting millions worldwide, is associated with microvascular complications, including diabetic retinopathy (dr) and periodontitis. understanding their interrelationship is crucial for comprehensive patient care. | international dental journal | eng | 2024 | Nov | Anil Sukumaran, Joseph Betsy, Pereira Merlyn Anjali, Arya Saket, Syamala Shirmila, Sweety Vishnupriya K, Jayasinghe Ruwan | oral health institute, hamad medical corporation, doha, qatar; college of dental medicine, qatar university, doha, qatar. electronic address: drsanil@gmail.com., department of periodontology, saveetha dental college and hospitals, saveetha institute of medical and technical sciences, saveetha university, chennai, india; pushpagiri institute of medical sciences and research centre, medicity, thiruvalla, kerala, india., department of ophthalmology, hamad general hospital, hamad medical corporation, doha, qatar., department of ophthalmology, hamad general hospital, hamad medical corporation, doha, qatar., hamad medical corporation, doha, qatar., pushpagiri institute of medical sciences and research centre, medicity, thiruvalla, kerala, india., department of oral medicine and periodontology, faculty of dental sciences, university of peradeniya, peradeniya, sri lanka. | international dental journal | int dent j | 0020-6539 | 1875-595X | 3.2 | 3.5 | DENTISTRY, ORAL SURGERY & MEDICINE|Q1|20/157 | hamad medical corporation, qatar university, saveetha institute of medical and technical sciences, saveetha university, pushpagiri institute of medical sciences and research centre, medicity, department of ophthalmology, hamad general hospital, hamad medical corporation, department of ophthalmology, hamad general hospital, hamad medical corporation, hamad medical corporation, pushpagiri institute of medical sciences and research centre, medicity, university of peradeniya | Unknown | qatar university | 251–300 | 35.6 | 275.5 | Low (0-50) |
| 94 | 93 | sex differences in myocardial infarction care and outcomes: a longitudinal scottish national data-linkage study. | we investigate sex disparities in management and outcomes of myocardial infarction (mi) in contemporary practice in scotland. | european journal of preventive cardiology | eng | 2024 | Nov | Pana Tiberiu A, Mamas Mamas A, Myint Phyo K, Dawson Dana K | school of medicine and dentistry, foresterhill, aberdeen cardiovascular and diabetes centre, institute of medical sciences, school of medicine, medical sciences and nutrition, university of aberdeen, aberdeen ab25 2zs, united kingdom., school of medicine, keele cardiovascular research group, david weatherall building, university road, keele university, stoke-on-trent, staffordshire st5 5bg, united kingdom., school of medicine and dentistry, foresterhill, aberdeen cardiovascular and diabetes centre, institute of medical sciences, school of medicine, medical sciences and nutrition, university of aberdeen, aberdeen ab25 2zs, united kingdom., school of medicine and dentistry, foresterhill, ageing clinical and experimental research team, school of medicine, medical sciences and nutrition, institute of applied health sciences, university of aberdeen, aberdeen ab25 2zs, united kingdom. | european journal of preventive cardiology | eur j prev cardiol | 2047-4873 | 2047-4881 | 8.4 | 7.1 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q1|16/220 | school of medicine and dentistry, institute of medical sciences, school of medicine, university of aberdeen, school of medicine, keele cardiovascular research group, keele university, school of medicine and dentistry, aberdeen cardiovascular and diabetes centre, institute of medical sciences, school of medicine, university of aberdeen, school of medicine and dentistry, ageing clinical and experimental research team, school of medicine, institute of applied health sciences, university of aberdeen | Unknown | keele university | 501–600 | 24.6 | 550.5 | Low (0-50) |
| 95 | 94 | novel retrieving device for coronary stent dislodgement. | stent dislodgement is a rare but particularly challenging complication. however, current treatment strategies are suboptimal. | bmc cardiovascular disorders | eng | 2024 | Nov | Han Zhan-Ying, Zhu Yong-Jian, Lu Wen-Jie, Wang Zhi-Fang, Yang Jian-Feng, Zhang Wen-Cai, Qiu Chun-Guang, Dong Jian-Zeng | department of cardiology, the first affiliated hospital of zhengzhou university, zhengzhou, china. hzy91@163.com., department of cardiology, the first affiliated hospital of zhengzhou university, zhengzhou, china., department of cardiology, the first affiliated hospital of zhengzhou university, zhengzhou, china., department of cardiology, xinxiang central hospital, xinxiang, china., department of cardiology, the fifth affiliated hospital of zhengzhou university, zhengzhou, china., department of cardiology, the first affiliated hospital of zhengzhou university, zhengzhou, china., department of cardiology, the first affiliated hospital of zhengzhou university, zhengzhou, china., department of cardiology, the first affiliated hospital of zhengzhou university, zhengzhou, china. | bmc cardiovascular disorders | bmc cardiovasc disor | 1471-2261 | 1471-2261 | 2.0 | 2.3 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q3|118/220 | department of cardiology, zhengzhou university, department of cardiology, zhengzhou university, department of cardiology, zhengzhou university, department of cardiology, xinxiang central hospital, department of cardiology, zhengzhou university, department of cardiology, zhengzhou university, department of cardiology, zhengzhou university, department of cardiology, zhengzhou university | Unknown | zhengzhou university | 601–800 | 19.8 | 700.5 | Low (0-50) |
| 96 | 95 | maternal polycystic ovary syndrome and offspring's risk of cardiovascular diseases in childhood and young adulthood. | children born to mothers with polycystic ovary syndrome have a higher prevalence of cardiovascular risk factors and of subclinical cardiovascular disease, but the association between maternal polycystic ovary syndrome and cardiovascular disease in offspring is unclear. we conduct a register-based cohort study of 6 839 703 live singleton births from denmark (1973-2016) and sweden (1973-2014) and follow them for up to 48 years. using cox regression models, we find that offspring of mothers with polycystic ovary syndrome have a higher risk of overall cardiovascular diseases and of its specific subtypes, independently of comorbidities related to polycystic ovary syndrome. cousin analyzes suggest that familial confounding does not explain our results. if our findings are replicated by future studies, children of women with polycystic ovary syndrome may benefit from early cardiovascular prevention efforts. | nature communications | eng | 2024 | Nov | Yang Fen, Wang Ziliang, Sørensen Henrik Toft, Janszky Imre, Gissler Mika, Yuan Wei, Miao Maohua, Roos Nathalie, Wikström Anna-Karin, Li Jiong, László Krisztina D | department of global public health, karolinska institutet, stockholm, sweden. fen.yang@ki.se., shanghai-most key laboratory of health and disease genomics, nhc key lab of reproduction regulation, shanghai institute for biomedical and pharmaceutical technologies, shanghai, china., department of clinical epidemiology, center for population medicine, aarhus university and aarhus university hospital, aarhus, denmark., department of global public health, karolinska institutet, stockholm, sweden., department of data and analytics, finnish institute for health and welfare, helsinki, finland., shanghai-most key laboratory of health and disease genomics, nhc key lab of reproduction regulation, shanghai institute for biomedical and pharmaceutical technologies, shanghai, china., shanghai-most key laboratory of health and disease genomics, nhc key lab of reproduction regulation, shanghai institute for biomedical and pharmaceutical technologies, shanghai, china., division of clinical epidemiology, department of medicine solna, karolinska university hospital and karolinska institutet, stockholm, sweden., department of women's and children's health, uppsala university, uppsala, sweden., department of clinical medicine and department of clinical epidemiology, aarhus university hospital, aarhus, denmark., department of global public health, karolinska institutet, stockholm, sweden. | nature communications | nat commun | 2041-1723 | 14.7 | 16.1 | MULTIDISCIPLINARY SCIENCES|Q1|8/134 | karolinska institutet, shanghai institute for biomedical and pharmaceutical technologies, aarhus university, aarhus university hospital, department of global public health, karolinska institutet, finnish institute for health and welfare, shanghai institute for biomedical and pharmaceutical technologies, shanghai institute for biomedical and pharmaceutical technologies, karolinska university hospital, karolinska institutet, uppsala university, aarhus university hospital, department of global public health, karolinska institutet | register-based cohort study | karolinska institute | 50 | 67.9 | 50.0 | Medium (50-75) | |
| 97 | 96 | immune checkpoint landscape of human atherosclerosis and influence of cardiometabolic factors. | immune checkpoint inhibitor (ici) therapies can increase the risk of cardiovascular events in survivors of cancer by worsening atherosclerosis. here we map the expression of immune checkpoints (ics) within human carotid and coronary atherosclerotic plaques, revealing a network of immune cell interactions that ici treatments can unintentionally target in arteries. we identify a population of mature, regulatory ccr7<sup>+</sup>fscn1<sup>+</sup> dendritic cells, similar to those described in tumors, as a hub of ic-mediated signaling within plaques. additionally, we show that type 2 diabetes and lipid-lowering therapies alter immune cell interactions through pd-1, ctla4, lag3 and other ic targets in clinical development, impacting plaque inflammation. this comprehensive map of the ic interactome in healthy and cardiometabolic disease states provides a framework for understanding the potential adverse and beneficial impacts of approved and investigational icis on atherosclerosis, setting the stage for designing ici strategies that minimize cardiovascular disease risk in cancer survivors. | nature cardiovascular research | eng | 2024 | Nov | Barcia Durán José Gabriel, Das Dayasagar, Gildea Michael, Amadori Letizia, Gourvest Morgane, Kaur Ravneet, Eberhardt Natalia, Smyrnis Panagiotis, Cilhoroz Burak, Sajja Swathy, Rahman Karishma, Fernandez Dawn M, Faries Peter, Narula Navneet, Vanguri Rami, Goldberg Ira J, Fisher Edward A, Berger Jeffrey S, Moore Kathryn J, Giannarelli Chiara | nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., division of cardiology, department of medicine, icahn school of medicine at mount sinai, new york, ny, usa., division of cardiology, department of medicine, icahn school of medicine at mount sinai, new york, ny, usa., department of surgery, vascular division, icahn school of medicine at mount sinai, new york, ny, usa., department of pathology, new york university grossman school of medicine, new york university langone health, new york, ny, usa., division of precision medicine, department of medicine, new york university grossman school of medicine, new york, ny, usa., division of endocrinology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa. kathryn.moore@nyulangone.org., nyu cardiovascular research center, division of cardiology, department of medicine, new york university grossman school of medicine, new york, ny, usa. chiara.giannarelli@nyulangone.org. | nature cardiovascular research | nat cardiovasc res | 2731-0590 | 9.4 | 9.4 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q1|13/220 | nyu cardiovascular research center, department of medicine, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, department of medicine, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, department of medicine, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, nyu cardiovascular research center, division of cardiology, new york university, grossman school of medicine, division of cardiology, icahn school of medicine, division of cardiology, icahn school of medicine, icahn school of medicine, new york university, grossman school of medicine, new york university langone health | clinical development | york university | 351–400 | 32.4 | 375.5 | Low (0-50) | |
| 98 | 97 | igfbp5 affects cardiomyocyte survival and functional recovery in mice following myocardial ischemia. | insulin-like growth factor-binding protein 5 (igfbp5) has been shown to be useful for the diagnosis and treatment of multiple tumors and cerebrovascular diseases. however, it is unknown whether igfbp5 is involved in myocardial repair following myocardial infarction (mi). here we show high expression of igfbp5 in multiple models of ischemic and hypoxic injury. igfbp5 affected the proliferation of neonatal rat cardiomyocytes (nrcms) and the cardiomyocyte apoptosis induced by oxygen-glucose deprivation (ogd). subsequently, heart-specific igfbp5 knockdown inhibited myocardial apoptosis and increased cardiomyocyte proliferation in mice with mi. during the chronic remodeling stage, heart-specific regulation of igfbp5 ameliorated pathological cardiac remodeling and dysfunction. mechanistically, igfbp5 regulated cardiomyocyte survival through the insulin-like growth factor 1 (igf1) receptor (igf1r)/protein kinase b (pkb/akt) pathway. in summary, our results provide mechanistic insights into the effect of igfbp5 on cardiomyocyte during cardiac repair. igfbp5 may represent a therapeutic target for myocardial ischemic injury. | communications biology | eng | 2024 | Nov | Zhu Qingqing, Lu Xinyi, Chen Mengli, Zhang Ting, Shi Mengsha, Yao Wenming, Zhang Haifeng, Gao Rongrong, Li Xinli, Zhou Yanli, Liao Shengen | division of cardiac surgery intensive care unit, department of cardiac surgery, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing, china., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china., department of cardiology, the affiliated suzhou hospital of nanjing medical university, suzhou, china., department of cardiovascular medicine, the air force hospital from eastern theater, nanjing, china., department of cardiology, the first affiliated hospital, college of medicine, zhejiang university, hangzhou, china., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china. zhyl88@qq.com., national key laboratory for innovation and transformation of luobing theory. department of cardiology, the first affiliated hospital of nanjing medical university, jiangsu province hospital, nanjing, china. shengenliao@163.com. | communications biology | commun biol | 2399-3642 | 5.2 | 5.6 | BIOLOGY|Q1|13/109 | nanjing drum tower hospital, nanjing university medical school, department of cardiology, nanjing medical university, jiangsu province hospital, department of cardiology, nanjing medical university, college of medicine, zhejiang university, department of cardiology, nanjing medical university, jiangsu province hospital, department of cardiology, nanjing medical university, jiangsu province hospital, department of cardiology, nanjing medical university, jiangsu province hospital, department of cardiology, nanjing medical university, jiangsu province hospital, department of cardiology, nanjing medical university, jiangsu province hospital, department of cardiology, nanjing medical university, jiangsu province hospital | Unknown | nanjing university | 73 | 61.7 | 73.0 | Medium (50-75) | |
| 99 | 98 | quantification of coronary artery calcification in systemic sclerosis using visual ordinal and deep learning scoring: association with systemic sclerosis clinical features. | to investigate the association between systemic sclerosis (ssc) clinical features and the extent and progression of coronary artery calcifications. | seminars in arthritis and rheumatism | eng | 2024 | Nov | Luo Yiming, Hanuska Daniel, Xu Jiehui, Salvatore Mary M, Bernstein Elana J | division of rheumatology, department of medicine, columbia university irving medical center, new york, ny, usa., hunter college, city university of new york, new york, ny, usa., division of biostatistics, department of population health, new york university grossman school of medicine, new york, ny, usa., department of radiology, columbia university irving medical center, new york, ny, usa., division of rheumatology, department of medicine, columbia university irving medical center, new york, ny, usa. electronic address: ejb2153@cumc.columbia.edu. | seminars in arthritis and rheumatism | semin arthritis rheu | 0049-0172 | 1532-866X | 4.6 | 4.9 | RHEUMATOLOGY|Q1|10/57 | columbia university irving medical center, hunter college, city university of new york, department of population health, new york university, grossman school of medicine, columbia university irving medical center, division of rheumatology, columbia university irving medical center | Unknown | columbia university | 17 | 89.7 | 17.0 | High (75-100) |
| 100 | 99 | acquired progressive torcular dural arteriovenous fistula after subtotal resection of peritorcular meningioma. | a woman in her mid-50s who had undergone a subtotal resection of a peritorcular meningioma 3 years earlier presented with symptoms suggestive of increased intracranial pressure. a delayed diagnosis of a torcular dural arteriovenous fistula (davf) diagnosis was made on mri. digital subtraction angiography confirmed a torcular davf (borden type ii). staged 3 rounds of transarterial (ta) embolisation were performed using n-butyl cyanoacrylate, ethylene vinyl alcohol copolymer and coils of the complex torcular davf, which significantly reduced the flow and corresponded with improved symptoms of pulsatile tinnitus, vision and headache. we reviewed previously reported cases of davfs that developed after craniotomy for meningioma resection. despite its rarity, a torcular davf can develop after craniotomy and progress from low to high grade due to its location. diagnosis requires a thorough understanding of subtle imaging findings, which may be present in follow-up studies obtained for tumour surveillance. | bmj case reports | eng | 2024 | Nov | Erdenebold Undrakh-Erdene, Weeks Adrienne, Walling Simon, Volders David | department of radiology, dalhousie university faculty of medicine, halifax, canada., division of neurosurgery, dalhousie university faculty of medicine, halifax, canada., division of neurosurgery, dalhousie university faculty of medicine, halifax, canada., department of radiology, dalhousie university faculty of medicine, halifax, canada david.volders@gmail.com. | bmj case reports | bmj case rep | 1757-790X | 0.6 | 0.0 | MEDICINE, GENERAL & INTERNAL|Q3|219/325 | dalhousie university faculty of medicine, division of neurosurgery, dalhousie university faculty of medicine, division of neurosurgery, dalhousie university faculty of medicine, dalhousie university faculty of medicine | follow-up studies | dalhousie university | 301–350 | 31.6 | 325.5 | Low (0-50) |