544 lines (544 with data), 355.5 kB

{
  "cells": [
    {
      "cell_type": "code",
      "execution_count": 202,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "GqSnI89Nrnuw",
        "outputId": "62ad0c6c-0fc7-46b7-abed-25299dfd197a"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Drive already mounted at /content/drive; to attempt to forcibly remount, call drive.mount(\"/content/drive\", force_remount=True).\n"
          ]
        }
      ],
      "source": [
        "from google.colab import drive\n",
        "drive.mount('/content/drive')"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 203,
      "metadata": {
        "id": "kopmEwP1V_cX"
      },
      "outputs": [],
      "source": [
        "import os\n",
        "import json\n",
        "import spacy\n",
        "import re\n",
        "import pandas as pd\n",
        "from concurrent.futures import ProcessPoolExecutor\n",
        "from datetime import datetime\n",
        "import scispacy"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 204,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "LgqE3eCWWGTA",
        "outputId": "904054b9-bccc-4a3e-eda2-2d484499004d"
      },
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "Collecting https://s3-us-west-2.amazonaws.com/ai2-s2-scispacy/releases/v0.5.4/en_ner_bc5cdr_md-0.5.4.tar.gz\n",
            "  Using cached https://s3-us-west-2.amazonaws.com/ai2-s2-scispacy/releases/v0.5.4/en_ner_bc5cdr_md-0.5.4.tar.gz (119.8 MB)\n",
            "  Preparing metadata (setup.py) ... \u001b[?25l\u001b[?25hdone\n",
            "Requirement already satisfied: spacy<3.8.0,>=3.7.4 in /usr/local/lib/python3.10/dist-packages (from en_ner_bc5cdr_md==0.5.4) (3.7.5)\n",
            "Requirement already satisfied: spacy-legacy<3.1.0,>=3.0.11 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (3.0.12)\n",
            "Requirement already satisfied: spacy-loggers<2.0.0,>=1.0.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (1.0.5)\n",
            "Requirement already satisfied: murmurhash<1.1.0,>=0.28.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (1.0.10)\n",
            "Requirement already satisfied: cymem<2.1.0,>=2.0.2 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2.0.8)\n",
            "Requirement already satisfied: preshed<3.1.0,>=3.0.2 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (3.0.9)\n",
            "Requirement already satisfied: thinc<8.3.0,>=8.2.2 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (8.2.5)\n",
            "Requirement already satisfied: wasabi<1.2.0,>=0.9.1 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (0.10.1)\n",
            "Requirement already satisfied: srsly<3.0.0,>=2.4.3 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2.4.8)\n",
            "Requirement already satisfied: catalogue<2.1.0,>=2.0.6 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2.0.10)\n",
            "Requirement already satisfied: weasel<0.5.0,>=0.1.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (0.4.1)\n",
            "Requirement already satisfied: typer<1.0.0,>=0.3.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (0.7.0)\n",
            "Requirement already satisfied: tqdm<5.0.0,>=4.38.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (4.66.5)\n",
            "Requirement already satisfied: requests<3.0.0,>=2.13.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2.32.3)\n",
            "Requirement already satisfied: pydantic!=1.8,!=1.8.1,<3.0.0,>=1.7.4 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (1.10.18)\n",
            "Requirement already satisfied: jinja2 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (3.1.4)\n",
            "Requirement already satisfied: setuptools in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (71.0.4)\n",
            "Requirement already satisfied: packaging>=20.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (24.1)\n",
            "Requirement already satisfied: langcodes<4.0.0,>=3.2.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (3.4.0)\n",
            "Requirement already satisfied: numpy>=1.19.0 in /usr/local/lib/python3.10/dist-packages (from spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (1.26.4)\n",
            "Requirement already satisfied: language-data>=1.2 in /usr/local/lib/python3.10/dist-packages (from langcodes<4.0.0,>=3.2.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (1.2.0)\n",
            "Requirement already satisfied: typing-extensions>=4.2.0 in /usr/local/lib/python3.10/dist-packages (from pydantic!=1.8,!=1.8.1,<3.0.0,>=1.7.4->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (4.12.2)\n",
            "Requirement already satisfied: charset-normalizer<4,>=2 in /usr/local/lib/python3.10/dist-packages (from requests<3.0.0,>=2.13.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (3.3.2)\n",
            "Requirement already satisfied: idna<4,>=2.5 in /usr/local/lib/python3.10/dist-packages (from requests<3.0.0,>=2.13.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (3.10)\n",
            "Requirement already satisfied: urllib3<3,>=1.21.1 in /usr/local/lib/python3.10/dist-packages (from requests<3.0.0,>=2.13.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2.2.3)\n",
            "Requirement already satisfied: certifi>=2017.4.17 in /usr/local/lib/python3.10/dist-packages (from requests<3.0.0,>=2.13.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2024.8.30)\n",
            "Requirement already satisfied: blis<0.8.0,>=0.7.8 in /usr/local/lib/python3.10/dist-packages (from thinc<8.3.0,>=8.2.2->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (0.7.11)\n",
            "Requirement already satisfied: confection<1.0.0,>=0.0.1 in /usr/local/lib/python3.10/dist-packages (from thinc<8.3.0,>=8.2.2->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (0.1.5)\n",
            "Requirement already satisfied: click<9.0.0,>=7.1.1 in /usr/local/lib/python3.10/dist-packages (from typer<1.0.0,>=0.3.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (8.1.7)\n",
            "Requirement already satisfied: cloudpathlib<1.0.0,>=0.7.0 in /usr/local/lib/python3.10/dist-packages (from weasel<0.5.0,>=0.1.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (0.19.0)\n",
            "Requirement already satisfied: smart-open<8.0.0,>=5.2.1 in /usr/local/lib/python3.10/dist-packages (from weasel<0.5.0,>=0.1.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (6.4.0)\n",
            "Requirement already satisfied: MarkupSafe>=2.0 in /usr/local/lib/python3.10/dist-packages (from jinja2->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (2.1.5)\n",
            "Requirement already satisfied: marisa-trie>=0.7.7 in /usr/local/lib/python3.10/dist-packages (from language-data>=1.2->langcodes<4.0.0,>=3.2.0->spacy<3.8.0,>=3.7.4->en_ner_bc5cdr_md==0.5.4) (1.2.0)\n"
          ]
        }
      ],
      "source": [
        "!pip install https://s3-us-west-2.amazonaws.com/ai2-s2-scispacy/releases/v0.5.4/en_ner_bc5cdr_md-0.5.4.tar.gz"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 205,
      "metadata": {
        "id": "yp7RH6c4WNXK"
      },
      "outputs": [],
      "source": [
        "# Load spaCy model for NLP processing for biomedical entities\n",
        "nlp = spacy.load(\"en_ner_bc5cdr_md\")"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 206,
      "metadata": {
        "id": "jaC4pylyWSH_"
      },
      "outputs": [],
      "source": [
        "# Paths to patient and clinical trial folders\n",
        "patient_folder = r'/content/drive/MyDrive/sample/patient_data'\n",
        "trial_folder = r'/content/drive/MyDrive/sample/clinical_trials'\n",
        "\n",
        "# Utility function to load all JSON files from a folder\n",
        "def load_json_files(folder_path):\n",
        "    files = [os.path.join(folder_path, f) for f in os.listdir(folder_path) if f.endswith('.json')]\n",
        "    data = []\n",
        "    for file in files:\n",
        "        with open(file, 'r') as f:\n",
        "            data.append(json.load(f))\n",
        "    return data"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 207,
      "metadata": {
        "id": "HyQjO5p8WYSK"
      },
      "outputs": [],
      "source": [
        "# Function to extract age from eligibility criteria text\n",
        "def extract_age_from_criteria(criteria_text, age_type=\"minimum\"):\n",
        "    \"\"\"Extracts age (either minimum or maximum) from the eligibility criteria text.\"\"\"\n",
        "    if age_type == \"minimum\":\n",
        "        # Look for the minimum age using a regex pattern (e.g., \"Age > 18 years\" or \"18 years or older\")\n",
        "        match = re.search(r'age\\s*(>=|>|older than)\\s*(\\d+)\\s*(years?|months?)', criteria_text, re.I)\n",
        "    else:\n",
        "        # Look for the maximum age using a regex pattern (e.g., \"Age <= 65 years\" or \"65 years or younger\")\n",
        "        match = re.search(r'age\\s*(<=|<|younger than)\\s*(\\d+)\\s*(years?|months?)', criteria_text, re.I)\n",
        "\n",
        "    if match:\n",
        "        age_value = int(match.group(2))\n",
        "        age_unit = match.group(3).lower()\n",
        "\n",
        "        # Convert age to months if necessary\n",
        "        if \"year\" in age_unit:\n",
        "            return age_value * 12\n",
        "        elif \"month\" in age_unit:\n",
        "            return age_value\n",
        "    return None\n",
        "\n",
        "# Function to convert age from string (e.g., \"18 Years\") to months\n",
        "def convert_age_to_months(age_str):\n",
        "    \"\"\"Converts an age string like '18 Years' or '6 Months' into months.\"\"\"\n",
        "    if not age_str:\n",
        "        return None  # Return None if age_str is None or empty\n",
        "    if 'month' in age_str.lower():\n",
        "        return int(re.search(r'\\d+', age_str).group())\n",
        "    elif 'year' in age_str.lower():\n",
        "        return int(re.search(r'\\d+', age_str).group()) * 12\n",
        "    return None\n",
        "\n",
        "# Function to calculate patient age in months\n",
        "def calculate_patient_age(birth_date_str):\n",
        "    \"\"\"Calculates patient's age in months from birth date.\"\"\"\n",
        "    birth_year = int(birth_date_str.split('-')[0])\n",
        "    current_year = datetime.now().year\n",
        "    return (current_year - birth_year) * 12\n",
        "\n",
        "# Function to extract inclusion and exclusion criteria from the eligibility criteria text\n",
        "def extract_criteria_from_text(criteria_text):\n",
        "    \"\"\"Extracts inclusion and exclusion criteria from a well-formatted string.\"\"\"\n",
        "    inclusion_criteria = \"\"\n",
        "    exclusion_criteria = \"\"\n",
        "\n",
        "    # Extract inclusion criteria (starts from \"INCLUSION CRITERIA\")\n",
        "    inclusion_match = re.search(r'INCLUSION CRITERIA:(.*?)(EXCLUSION CRITERIA:|$)', criteria_text, re.S | re.I)\n",
        "    if inclusion_match:\n",
        "        inclusion_criteria = inclusion_match.group(1).strip()\n",
        "\n",
        "    # Extract exclusion criteria (starts from \"EXCLUSION CRITERIA\")\n",
        "    exclusion_match = re.search(r'EXCLUSION CRITERIA:(.*)', criteria_text, re.S | re.I)\n",
        "    if exclusion_match:\n",
        "        exclusion_criteria = exclusion_match.group(1).strip()\n",
        "\n",
        "    return inclusion_criteria, exclusion_criteria"
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "# Function to process inclusion and exclusion criteria using NLP\n",
        "def process_criteria_with_nlp(criteria_text):\n",
        "    \"\"\"Processes inclusion and exclusion criteria using NLP techniques.\"\"\"\n",
        "    inclusion_text, exclusion_text = extract_criteria_from_text(criteria_text)\n",
        "    inclusion_conditions = set()  # Using set to avoid duplicates\n",
        "    exclusion_conditions = set()  # Using set to avoid duplicates\n",
        "\n",
        "    # Process inclusion criteria\n",
        "    inclusion_doc = nlp(inclusion_text)\n",
        "    for ent in inclusion_doc.ents:\n",
        "        if ent.label_ == 'DISEASE':\n",
        "            inclusion_conditions.add(ent.text.lower())\n",
        "\n",
        "    # Process exclusion criteria (if any)\n",
        "    exclusion_doc = nlp(exclusion_text)\n",
        "    for ent in exclusion_doc.ents:\n",
        "        if ent.label_ == 'DISEASE' and ent.text.lower() not in inclusion_conditions:\n",
        "            exclusion_conditions.add(ent.text.lower())\n",
        "\n",
        "    #print(\"Inclusion conditions: \" + \", \".join(inclusion_conditions))\n",
        "    #print(\"Exclusion conditions: \" + \", \".join(exclusion_conditions))\n",
        "\n",
        "    return {\n",
        "        'inclusion': {\n",
        "            'conditions': list(inclusion_conditions)  # Converting back to list for consistency\n",
        "        },\n",
        "        'exclusion': {\n",
        "            'conditions': list(exclusion_conditions)  # Converting back to list for consistency\n",
        "        }\n",
        "    }"
      ],
      "metadata": {
        "id": "hd3N7Cq-cvv-"
      },
      "execution_count": 208,
      "outputs": []
    },
    {
      "cell_type": "code",
      "execution_count": 209,
      "metadata": {
        "id": "bcSLfzo-WzuQ"
      },
      "outputs": [],
      "source": [
        "# Function to match patient data to clinical trial based on inclusion and exclusion criteria\n",
        "def match_patient_to_trial(patient, trial_criteria, min_age_months, max_age_months):\n",
        "    \"\"\"Matches a patient to a clinical trial based on dynamic criteria.\"\"\"\n",
        "    # Calculate patient's age in months\n",
        "    patient_age_months = calculate_patient_age(patient['entry'][0]['resource']['birthDate'])\n",
        "\n",
        "    # Safely get patient conditions (if not present, use an empty list)\n",
        "    patient_conditions = set()  # Using set to avoid duplicates\n",
        "    for entry in patient.get('entry', []):\n",
        "        resource = entry.get('resource', {})\n",
        "\n",
        "        # Extract condition from 'Condition' resource\n",
        "        if resource.get('resourceType') == 'Condition':\n",
        "            condition = resource.get('code', []).get('coding', [])[0].get('display', '').lower()\n",
        "            if condition:\n",
        "                patient_conditions.add(condition)\n",
        "\n",
        "        # Extract condition from 'Encounter' resource\n",
        "        if resource.get('resourceType') == 'Encounter':\n",
        "            for condition in resource.get('reasonCode', []):\n",
        "                display = condition.get('coding', [])[0].get('display', '').lower()\n",
        "                if display:\n",
        "                    patient_conditions.add(display)\n",
        "\n",
        "\n",
        "    # Also extract allergy conditions from AllergyIntolerance section (if applicable)\n",
        "    patient_allergies = set(\n",
        "        allergy['code']['text'].lower()\n",
        "        for allergy in patient.get('AllergyIntolerance', [])\n",
        "    )\n",
        "\n",
        "    # Age matching\n",
        "    if not (min_age_months <= patient_age_months <= max_age_months):\n",
        "        return False, []\n",
        "\n",
        "    # Inclusion criteria matching\n",
        "    inclusion = trial_criteria['inclusion']\n",
        "    matched_criteria = []\n",
        "    if inclusion['conditions']:\n",
        "        # Find the conditions that match both the patient conditions and inclusion criteria\n",
        "        matched_criteria = [cond for cond in inclusion['conditions'] if cond in patient_conditions]\n",
        "\n",
        "        # If no conditions match, return False\n",
        "        if not matched_criteria:\n",
        "            return False, []\n",
        "\n",
        "    # Exclusion criteria matching (also check allergies)\n",
        "    exclusion = trial_criteria['exclusion']\n",
        "    if exclusion['conditions'] and (any(cond in patient_conditions for cond in exclusion['conditions']) or any(cond in patient_allergies for cond in exclusion['conditions'])):\n",
        "        return False, []\n",
        "\n",
        "    # Return True if there's a match, along with the matched criteria\n",
        "    return True, matched_criteria\n"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 210,
      "metadata": {
        "id": "LiEwfuOoW6dx"
      },
      "outputs": [],
      "source": [
        "# Function to process a single patient file\n",
        "def process_patient_file(patient, trials_data):\n",
        "    patient_id = patient['entry'][0]['resource']['id']\n",
        "    eligible_trials = []\n",
        "\n",
        "    for trial in trials_data:\n",
        "        trial_id = trial['protocolSection']['identificationModule']['nctId']\n",
        "        trial_name = trial['protocolSection']['identificationModule']['briefTitle']\n",
        "        eligibility_text = trial['protocolSection']['eligibilityModule']['eligibilityCriteria']\n",
        "\n",
        "        # Get minimumAge and maximumAge from the trial data or extract from eligibilityCriteria\n",
        "        min_age_str = trial['protocolSection']['eligibilityModule'].get('minimumAge', None)\n",
        "        max_age_str = trial['protocolSection']['eligibilityModule'].get('maximumAge', None)\n",
        "\n",
        "        # If minimumAge is not available, extract from eligibility criteria text\n",
        "        if not min_age_str:\n",
        "            min_age_months = extract_age_from_criteria(eligibility_text, age_type=\"minimum\")\n",
        "        else:\n",
        "            min_age_months = convert_age_to_months(min_age_str)\n",
        "\n",
        "        # If maximumAge is not available, extract from eligibility criteria text\n",
        "        if not max_age_str:\n",
        "            max_age_months = extract_age_from_criteria(eligibility_text, age_type=\"maximum\")\n",
        "        else:\n",
        "            max_age_months = convert_age_to_months(max_age_str)\n",
        "\n",
        "        # If min_age_months is still None, default to 18 years\n",
        "        if min_age_months is None:\n",
        "            min_age_months = 18 * 12  # Default to 18 years\n",
        "\n",
        "        # If max_age_months is still None, default to 100 years\n",
        "        if max_age_months is None:\n",
        "            max_age_months = 100 * 12  # Default to 100 years\n",
        "\n",
        "        # Extract and process inclusion and exclusion criteria using NLP\n",
        "        trial_criteria = process_criteria_with_nlp(eligibility_text)\n",
        "\n",
        "        # Check if the patient is eligible\n",
        "        bool1, matched_criteria = match_patient_to_trial(patient, trial_criteria, min_age_months, max_age_months)\n",
        "        if bool1:\n",
        "            eligible_trials.append({\n",
        "                'trialId': trial_id,\n",
        "                'trialName': trial_name,\n",
        "                'eligibilityCriteriaMet': matched_criteria\n",
        "            })\n",
        "\n",
        "    return {\n",
        "        'patientId': patient_id,\n",
        "        'eligibleTrials': eligible_trials\n",
        "    }"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 211,
      "metadata": {
        "id": "CjxIB8izXCVj"
      },
      "outputs": [],
      "source": [
        "# Main function to process all patients and trials\n",
        "def match_patients_to_trials(patient_folder, trial_folder):\n",
        "    # Load patient and trial data\n",
        "    patient_data = load_json_files(patient_folder)\n",
        "    trial_data = load_json_files(trial_folder)\n",
        "\n",
        "    # Use ProcessPoolExecutor for parallel processing\n",
        "    results = []\n",
        "    with ProcessPoolExecutor() as executor:\n",
        "        futures = [executor.submit(process_patient_file, patient, trial_data) for patient in patient_data]\n",
        "        i = 0\n",
        "        for future in futures:\n",
        "          print(i)\n",
        "          i += 1\n",
        "          results.append(future.result())\n",
        "\n",
        "    return results"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 212,
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        "id": "2EnrhrYeXGf8",
        "outputId": "bea5708d-ae05-478e-b7a0-92e1695e1ccb"
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          "text": [
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            "Results[{'patientId': '964576b0-7527-b34a-d7c8-37cee9f6e396', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197142', 'trialName': 'Cardiac Arrest Registry of the Lombardia Region (Lombardia CARe)', 'eligibilityCriteriaMet': ['cardiac arrest']}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': 'e266fa7d-d981-ef94-45e7-3d253425c3f9', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217227', 'trialName': 'Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03209687', 'trialName': 'The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF Cycles', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216785', 'trialName': 'SNUH MICU Cohort Study of PICS', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03212976', 'trialName': 'Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03206814', 'trialName': 'Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03215836', 'trialName': 'Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03193333', 'trialName': 'PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': '2783a318-7e6d-e3a7-fce7-2a70e66c6ba9', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03202303', 'trialName': 'Cannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - 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Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': 'f0660412-c40e-4d5c-5b11-08b6da289331', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217227', 'trialName': 'Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216785', 'trialName': 'SNUH MICU Cohort Study of PICS', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03212976', 'trialName': 'Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03207945', 'trialName': 'Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03206814', 'trialName': 'Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03215836', 'trialName': 'Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics', 'eligibilityCriteriaMet': ['hypertension', 'asthma']}, {'trialId': 'NCT03191656', 'trialName': 'REDUCE LAP-HF III Corvia Protocol 1701', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193333', 'trialName': 'PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}]\n"
          ]
        }
      ],
      "source": [
        "results = match_patients_to_trials(patient_folder, trial_folder)\n",
        "\n",
        "print(\"Results\" + str(results))"
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "print(results)"
      ],
      "metadata": {
        "id": "odFWlzSgzCbg"
      },
      "execution_count": 213,
      "outputs": []
    },
    {
      "cell_type": "code",
      "source": [
        "# Saving results as a JSON file\n",
        "with open('results.json', 'w') as f:\n",
        "  json.dump(results, f, indent=4)"
      ],
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "xi0VPEEGgTnF",
        "outputId": "a1d3ba97-085a-4673-82d0-9193f00208b3"
      },
      "execution_count": 214,
      "outputs": [
        {
          "output_type": "stream",
          "name": "stdout",
          "text": [
            "[{'patientId': '964576b0-7527-b34a-d7c8-37cee9f6e396', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197142', 'trialName': 'Cardiac Arrest Registry of the Lombardia Region (Lombardia CARe)', 'eligibilityCriteriaMet': ['cardiac arrest']}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': 'e266fa7d-d981-ef94-45e7-3d253425c3f9', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217227', 'trialName': 'Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03209687', 'trialName': 'The Value of Addition of Human Menopausal Gonadotropin Drug Following Oocytes Retrieval in IVF Cycles', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216785', 'trialName': 'SNUH MICU Cohort Study of PICS', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03212976', 'trialName': 'Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03206814', 'trialName': 'Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03215836', 'trialName': 'Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03193333', 'trialName': 'PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': '2783a318-7e6d-e3a7-fce7-2a70e66c6ba9', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03202303', 'trialName': 'Cannabidivarin (CBDV) vs. Placebo in Children With Autism Spectrum Disorder (ASD)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - 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Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': 'e1245016-60e8-f2d1-728b-5f32bf4b387b', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217227', 'trialName': 'Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR', 'eligibilityCriteriaMet': ['diabetes']}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216785', 'trialName': 'SNUH MICU Cohort Study of PICS', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03215836', 'trialName': 'Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics', 'eligibilityCriteriaMet': ['diabetes']}, {'trialId': 'NCT03191656', 'trialName': 'REDUCE LAP-HF III Corvia Protocol 1701', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': '165a4435-31ff-0493-eb3f-3a86106f3a59', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217227', 'trialName': 'Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR', 'eligibilityCriteriaMet': ['diabetes']}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216785', 'trialName': 'SNUH MICU Cohort Study of PICS', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03215836', 'trialName': 'Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics', 'eligibilityCriteriaMet': ['diabetes']}, {'trialId': 'NCT03191656', 'trialName': 'REDUCE LAP-HF III Corvia Protocol 1701', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}, {'patientId': 'f0660412-c40e-4d5c-5b11-08b6da289331', 'eligibleTrials': [{'trialId': 'NCT03217305', 'trialName': 'Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation After Cardiac Surgery', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217227', 'trialName': 'Evaluating Myocardial Ischemia in Chest Pain Using Exercise CMR', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03210831', 'trialName': 'Early Predictors of Necrotizing Enterocolitis in Neonates', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216785', 'trialName': 'SNUH MICU Cohort Study of PICS', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03217110', 'trialName': 'Cerebellar Stimulation and Cognitive Control', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216798', 'trialName': 'Client and Provider Preferences for HIV Care', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03216525', 'trialName': 'Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03212976', 'trialName': 'Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03207945', 'trialName': 'Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03206814', 'trialName': 'Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03193892', 'trialName': 'A National Registry on Chinese Patients With Lymphangioleiomyomatosis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197350', 'trialName': 'Characterization of Heart Failure With Preserved Ejection Fraction', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200964', 'trialName': 'OS Anesthesia Followup of All Bariatric Procedures at One Hospital', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03206372', 'trialName': 'Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03215836', 'trialName': 'Obesity, Metabolic Dysregulation and the Airway Epithelium in Asthmatics', 'eligibilityCriteriaMet': ['hypertension', 'asthma']}, {'trialId': 'NCT03191656', 'trialName': 'REDUCE LAP-HF III Corvia Protocol 1701', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193333', 'trialName': 'PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)', 'eligibilityCriteriaMet': ['hypertension']}, {'trialId': 'NCT03204357', 'trialName': 'Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03199066', 'trialName': 'Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03198572', 'trialName': 'Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192956', 'trialName': 'Markers of Central Nervous System Injury in Decompression Sickness', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192436', 'trialName': 'Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03192800', 'trialName': 'Clinical Outcome in Patients With Spinal Dural Arteriovenous Fistulas (COPSDAVF)', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03197259', 'trialName': 'Chronic Lymphocytic Leukemia Registry Study - Multicenter Prospective National Study', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03200379', 'trialName': 'Nation-wide Hepatitis C Virus (HCV) Registry in Taiwan', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03204370', 'trialName': 'Natural History of Atypical Morquio A Disease', 'eligibilityCriteriaMet': []}, {'trialId': 'NCT03193151', 'trialName': 'Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation', 'eligibilityCriteriaMet': []}]}]\n"
          ]
        }
      ]
    },
    {
      "cell_type": "code",
      "source": [
        "# Convert results to a DataFrame for Excel export\n",
        "df_results = pd.json_normalize(results, record_path=['eligibleTrials'], meta=['patientId'])\n",
        "df_results.to_excel('results.xlsx', index=False)"
      ],
      "metadata": {
        "id": "sWOZhgXlgryf"
      },
      "execution_count": 215,
      "outputs": []
    }
  ],
  "metadata": {
    "colab": {
      "provenance": []
    },
    "kernelspec": {
      "display_name": "Python 3",
      "name": "python3"
    },
    "language_info": {
      "name": "python"
    }
  },
  "nbformat": 4,
  "nbformat_minor": 0
}