--- a
+++ b/man/Study.Rd
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+% Generated by roxygen2: do not edit by hand
+% Please edit documentation in R/study_constructors.R
+\name{Study}
+\alias{Study}
+\title{Constructor for a Study}
+\usage{
+Study(alpha, power, HR, r, N, study.duration, ctrl.median, k, acc.period,
+  two.sided, shape = 1, dropout = NULL, lag.settings = NullLag())
+}
+\arguments{
+\item{alpha}{Significance level [0,1] (see also two-sided indicator)}
+
+\item{power}{Power [0,1]}
+
+\item{HR}{Hazard ratio to be detected}
+
+\item{r}{Control:Experimental subject balance (1:r), i.e. nE/nC=r. r=1 corresponds to equally 
+many subjects in both arms. 2 means we have twice the number of subjects in the experimental arm.}
+
+\item{N}{Number of subjects to be recruit (integer)}
+
+\item{study.duration}{Number of months the study will be going.}
+
+\item{ctrl.median}{Median time to an event in the control group.}
+
+\item{k}{non-uniformity of accrual (integer, 1=uniform). Non-uniform accrual is allowed for 
+using the following distribution for the probability of a patient entering the trial at time \eqn{b} 
+within the accrual period \eqn{[0,B]}: \eqn{F(b)=b_k/B_k}; \eqn{f(b)=k b_{k-1}/B_k} where \eqn{k} is the 
+measure of non-uniformity (\eqn{k>0}). \eqn{k=1} indicates uniform accrual. This implies that during 
+the first half of the accrual period, \eqn{1/2^k} of the patients will be recruited. Half of the patients 
+will be recruited by time \eqn{B/2^{1/k}}.}
+
+\item{acc.period}{Accrual time.}
+
+\item{two.sided}{If TRUE, two sided test will be used (i.e. alpha/2).}
+
+\item{shape}{The Weibull shape parameter}
+
+\item{dropout}{if subjects drop out in study (due to competing risks not as there is a finite follow up time)
+then this argument should contain a list with proportion and time and optionally shape i.e.
+\code{dropout=list(proportion=0.03,time=12,shape=1.2)} meaning in the absence of events 3% of subjects
+will have dropped out after 12 months with a Weibull hazard rate with shape=1.2. If shape is not included then 
+it defaults to 1 (exponential rate). If dropout is NULL then no subjects will drop out}
+
+\item{lag.settings}{The \code{LaggedEffect} object describing any lag effect for the study}
+}
+\description{
+Constructor for a Study
+}
+