--- a
+++ b/processing/MACCROBAT/28403099.ann
@@ -0,0 +1,429 @@
+T1	Age 2 13	60-year-old
+T2	Sex 14 17	man
+T3	Clinical_event 18 27	presented
+E1	Clinical_event:T3 
+T4	Sign_symptom 51 61	metastatic
+E2	Sign_symptom:T4 
+T5	Biological_structure 62 72	lymph node
+T6	Biological_structure 35 50	retroperitoneal
+R1	MODIFY Arg1:T6 Arg2:E2	
+R2	MODIFY Arg1:T5 Arg2:E2	
+T7	Diagnostic_procedure 76 94	magnetic resonance
+E3	Diagnostic_procedure:T7 
+T8	Diagnostic_procedure 96 98	MR
+E4	Diagnostic_procedure:T8 
+R3	IDENTICAL Arg1:E4 Arg2:E3	
+T9	Therapeutic_procedure 138 147	resection
+E5	Therapeutic_procedure:T9 
+T10	Date 151 155	2010
+E6	Date:T10 
+T11	Biological_structure 126 137	right liver
+R4	MODIFY Arg1:T11 Arg2:E5	
+T12	Therapeutic_procedure 173 182	resection
+E7	Therapeutic_procedure:T12 
+T13	Biological_structure 157 172	pulmonary wedge
+R5	MODIFY Arg1:T13 Arg2:E7	
+T14	Date 186 190	2012
+E8	Date:T14 
+R6	BEFORE Arg1:E8 Arg2:E7	
+T15	Therapeutic_procedure 196 227	transarterial chemoembolization
+E9	Therapeutic_procedure:T15 
+T16	Detailed_description 228 233	twice
+T17	Date 237 241	2014
+E10	Date:T17 
+R7	MODIFY Arg1:T16 Arg2:E9	
+T18	History 126 155	right liver resection in 2010
+T19	History 157 190	pulmonary wedge resection in 2012
+T20	History 196 241	transarterial chemoembolization twice in 2014
+T21	Diagnostic_procedure 270 279	pathology
+E11	Diagnostic_procedure:T21 
+T22	Disease_disorder 300 312	liver cancer
+E12	Disease_disorder:T22 
+A1	POLARITY E12 UNCERTAIN
+T23	Detailed_description 294 299	mixed
+R8	MODIFY Arg1:T23 Arg2:E12	
+T24	Disease_disorder 340 351	lung cancer
+E13	Disease_disorder:T24 
+T25	Detailed_description 318 339	poorly differentiated
+R9	MODIFY Arg1:T25 Arg2:E13	
+T26	Sign_symptom 363 373	metastasis
+E14	Sign_symptom:T26 
+T27	Biological_structure 357 362	liver
+R10	MODIFY Arg1:T27 Arg2:E14	
+T28	Diagnostic_procedure 378 389	examination
+E15	Diagnostic_procedure:T28 
+T29	Coreference 395 400	tumor
+E16	Coreference:T29 
+R11	IDENTICAL Arg1:E16 Arg2:E2	
+T30	Biological_structure 423 431	duodenum
+T31	Biological_structure 433 441	pancreas
+T32	Biological_structure 443 450	stomach
+T33	Biological_structure 456 475	hepatic portal vein
+R12	MODIFY Arg1:T30 Arg2:E16	
+R13	MODIFY Arg1:T31 Arg2:E16	
+R14	MODIFY Arg1:T32 Arg2:E16	
+R15	MODIFY Arg1:T33 Arg2:E16	
+T34	Sign_symptom 507 513	masses
+E17	Sign_symptom:T34 
+T35	Detailed_description 494 506	unresectable
+R16	MODIFY Arg1:T35 Arg2:E17	
+T36	History 518 544	hypertension over 10 years
+T37	History 549 591	chronic HBV-related cirrhosis for 30 years
+T38	Sign_symptom 518 530	hypertension
+E18	Sign_symptom:T38 
+T39	Duration 536 544	10 years
+E19	Duration:T39 
+R17	MODIFY Arg1:E19 Arg2:E18	
+T40	Disease_disorder 557 578	HBV-related cirrhosis
+E20	Disease_disorder:T40 
+T41	Detailed_description 549 556	chronic
+R18	MODIFY Arg1:T41 Arg2:E20	
+T42	Duration 583 591	30 years
+E21	Duration:T42 
+R19	MODIFY Arg1:E21 Arg2:E20	
+T43	Medication 617 627	lamivudine
+E22	Medication:T43 
+T44	Dosage 628 637	100 mg qd
+R20	MODIFY Arg1:T44 Arg2:E22	
+T45	Medication 643 661	adefovir dipivoxil
+E23	Medication:T45 
+T46	Dosage 662 670	10 mg qd
+R21	MODIFY Arg1:T46 Arg2:E23	
+T47	Duration 675 682	6 years
+E24	Duration:T47 
+R22	MODIFY Arg1:E24 Arg2:E23	
+R23	MODIFY Arg1:E24 Arg2:E22	
+T48	Diagnostic_procedure 703 719	body temperature
+E25	Diagnostic_procedure:T48 
+T49	Lab_value 694 702	constant
+R24	MODIFY Arg1:T49 Arg2:E25	
+T50	Lab_value 723 728	37 °C
+R25	MODIFY Arg1:T50 Arg2:E25	
+T51	Diagnostic_procedure 734 748	blood pressure
+E26	Diagnostic_procedure:T51 
+T52	Lab_value 752 764	148/96 mm Hg
+R26	MODIFY Arg1:T52 Arg2:E26	
+T53	Diagnostic_procedure 774 779	pulse
+E27	Diagnostic_procedure:T53 
+T54	Lab_value 783 804	77 beats every minute
+R27	MODIFY Arg1:T54 Arg2:E27	
+T55	Sign_symptom 852 856	pain
+E28	Sign_symptom:T55 
+A2	POLARITY E28 NEG
+T56	Biological_structure 842 851	abdominal
+T57	Biological_structure 858 867	abdominal
+T58	Sign_symptom 868 878	distention
+E29	Sign_symptom:T58 
+T59	Sign_symptom 880 886	nausea
+E30	Sign_symptom:T59 
+T60	Sign_symptom 892 900	vomiting
+E31	Sign_symptom:T60 
+R28	MODIFY Arg1:T57 Arg2:E29	
+R29	MODIFY Arg1:T56 Arg2:E28	
+T61	Diagnostic_procedure 915 928	tumor markers
+E32	Diagnostic_procedure:T61 
+T62	Lab_value 954 960	normal
+R30	MODIFY Arg1:T62 Arg2:E32	
+T63	Diagnostic_procedure 975 999	carcinoembryonic antigen
+E33	Diagnostic_procedure:T63 
+T64	Diagnostic_procedure 1011 1028	alpha fetoprotein
+E34	Diagnostic_procedure:T64 
+T65	Diagnostic_procedure 1045 1070	carbohydrate antigen 19–9
+E35	Diagnostic_procedure:T65 
+T66	Lab_value 1000 1009	3.7 ng/mL
+T67	Lab_value 1029 1039	17.3 ng/mL
+T68	Lab_value 1078 1086	6.1 U/mL
+R31	MODIFY Arg1:T68 Arg2:E35	
+R32	SUB_PROCEDURE Arg1:E33 Arg2:E32	
+R33	SUB_PROCEDURE Arg1:E34 Arg2:E32	
+R34	SUB_PROCEDURE Arg1:E35 Arg2:E32	
+T69	Therapeutic_procedure 1233 1241	ablation
+E36	Therapeutic_procedure:T69 
+T70	Detailed_description 1227 1232	local
+R35	MODIFY Arg1:T70 Arg2:E36	
+T71	Diagnostic_procedure 1261 1274	Choi criteria
+E37	Diagnostic_procedure:T71 
+T72	Diagnostic_procedure 1348 1367	computed tomography
+E38	Diagnostic_procedure:T72 
+T73	Diagnostic_procedure 1369 1371	CT
+E39	Diagnostic_procedure:T73 
+R36	IDENTICAL Arg1:E39 Arg2:E38	
+T74	Other_entity 1382 1756	complete response, disappearance of all lesions and no new lesions; partial response (PR), a decrease in size of 10% or a decrease in tumor density over 15% on CT and no new lesions; stable disease, not fit for complete response, PR, or progressive disease; and progressive disease, an increase in tumor size over 10% and not fit for PR by tumor density on CT or new lesions
+#1	AnnotatorNotes T74	This is just a description of the criteria
+T75	Diagnostic_procedure 1775 1777	MR
+E40	Diagnostic_procedure:T75 
+T76	Sign_symptom 1800 1804	mass
+E41	Sign_symptom:T76 
+T77	Area 1808 1820	2.8 × 3.5 cm
+R37	MODIFY Arg1:T77 Arg2:E41	
+T78	Biological_structure 1842 1850	duodenum
+T79	Biological_structure 1852 1860	pancreas
+T80	Biological_structure 1866 1879	blood vessels
+R38	MODIFY Arg1:T78 Arg2:E41	
+R39	MODIFY Arg1:T79 Arg2:E41	
+R40	MODIFY Arg1:T80 Arg2:E41	
+T81	Sign_symptom 1946 1962	signal intensity
+E42	Sign_symptom:T81 
+T82	Diagnostic_procedure 1914 1916	MR
+E43	Diagnostic_procedure:T82 
+T83	Detailed_description 1897 1912	substance phase
+R41	MODIFY Arg1:T83 Arg2:E43	
+T84	Severity 1934 1945	mildly high
+R42	MODIFY Arg1:T84 Arg2:E42	
+T85	Coreference 1974 1979	tumor
+E44	Coreference:T85 
+R43	IDENTICAL Arg1:E44 Arg2:E41	
+T86	Sign_symptom 2001 2017	signal intensity
+E45	Sign_symptom:T86 
+T87	Severity 1984 2000	intermediate low
+R44	MODIFY Arg1:T87 Arg2:E45	
+T88	Biological_structure 2025 2040	solid component
+T89	Biological_structure 2052 2057	walls
+R45	MODIFY Arg1:E44 Arg2:E42	
+R46	MODIFY Arg1:T88 Arg2:E45	
+R47	MODIFY Arg1:T89 Arg2:E45	
+T90	Therapeutic_procedure 2087 2095	ablation
+E46	Therapeutic_procedure:T90 
+T91	Sign_symptom 2130 2146	hyperechoic area
+E47	Sign_symptom:T91 
+T92	Diagnostic_procedure 2156 2158	US
+E48	Diagnostic_procedure:T92 
+#2	AnnotatorNotes E48	ultrasound
+T93	Detailed_description 2150 2155	axial
+R48	MODIFY Arg1:T93 Arg2:E48	
+T94	Severity 2125 2129	mild
+T95	Biological_structure 2109 2124	retroperitoneal
+R49	MODIFY Arg1:T95 Arg2:E47	
+R50	MODIFY Arg1:T94 Arg2:E47	
+T96	Diagnostic_procedure 2240 2248	biopsies
+E49	Diagnostic_procedure:T96 
+T97	Biological_structure 2227 2239	transhepatic
+T98	Detailed_description 2214 2226	percutaneous
+R51	MODIFY Arg1:T97 Arg2:E49	
+R52	MODIFY Arg1:T98 Arg2:E49	
+T99	Therapeutic_procedure 2253 2262	ablations
+E50	Therapeutic_procedure:T99 
+T100	Duration 2335 2351	about 40 minutes
+E51	Duration:T100 
+T101	Medication 2358 2374	local anesthesia
+E52	Medication:T101 
+T102	Medication 2384 2392	sedation
+E53	Medication:T102 
+T103	Diagnostic_procedure 2402 2417	ultrasonography
+E54	Diagnostic_procedure:T103 
+T104	Detailed_description 2421 2432	real-timely
+#3	AnnotatorNotes T104	[sp]
+R53	MODIFY Arg1:T104 Arg2:E54	
+T105	Sign_symptom 4615 4627	side effects
+E55	Sign_symptom:T105 
+A3	POLARITY E55 NEG
+T106	Diagnostic_procedure 4439 4452	tumor markers
+E56	Diagnostic_procedure:T106 
+T107	Diagnostic_procedure 4468 4492	carcinoembryonic antigen
+E57	Diagnostic_procedure:T107 
+T108	Diagnostic_procedure 4494 4511	alpha fetoprotein
+E58	Diagnostic_procedure:T108 
+T109	Diagnostic_procedure 4517 4542	carbohydrate antigen 19–9
+E59	Diagnostic_procedure:T109 
+T110	Lab_value 4553 4562	3.6 ng/mL
+R54	MODIFY Arg1:T110 Arg2:E57	
+T111	Lab_value 4564 4574	26.7 ng/mL
+R55	MODIFY Arg1:T111 Arg2:E58	
+T112	Lab_value 4580 4588	8.1 U/mL
+R56	MODIFY Arg1:T112 Arg2:E59	
+R57	SUB_PROCEDURE Arg1:E57 Arg2:E56	
+R58	SUB_PROCEDURE Arg1:E58 Arg2:E56	
+R59	SUB_PROCEDURE Arg1:E59 Arg2:E56	
+T113	Therapeutic_procedure 2465 2477	laser fibers
+E60	Therapeutic_procedure:T113 
+R60	SUB_PROCEDURE Arg1:E60 Arg2:E50	
+T114	Detailed_description 2456 2464	2 Nd:YAG
+R61	MODIFY Arg1:T114 Arg2:E60	
+T115	Detailed_description 2479 2506	Echolaser X4, ESAOTE, Italy
+R62	MODIFY Arg1:T115 Arg2:E60	
+T116	Detailed_description 2511 2526	0.3 mm diameter
+T117	Detailed_description 2527 2557	through a 21-gauge Chiba needl
+T118	Sign_symptom 2568 2575	lesions
+E61	Sign_symptom:T118 
+R63	MODIFY Arg1:T116 Arg2:E60	
+R64	MODIFY Arg1:T117 Arg2:E60	
+T119	Therapeutic_procedure 2639 2647	ablation
+E62	Therapeutic_procedure:T119 
+T120	Detailed_description 2665 2686	area from 12 to 15 mm
+T121	Detailed_description 2696 2708	power of 5 W
+T122	Detailed_description 2712 2726	5 to 6 minutes
+R65	MODIFY Arg1:T120 Arg2:E62	
+R66	MODIFY Arg1:T121 Arg2:E62	
+#4	AnnotatorNotes T122	not a duration, but a function of the procedure
+R67	MODIFY Arg1:T122 Arg2:E62	
+T123	Diagnostic_procedure 2752 2767	ultrasonography
+E63	Diagnostic_procedure:T123 
+T124	Sign_symptom 2790 2796	lesion
+E64	Sign_symptom:T124 
+T125	Sign_symptom 2814 2830	hyperechoic zone
+E65	Sign_symptom:T125 
+T126	Diagnostic_procedure 2875 2903	contrast-enhanced ultrasound
+E66	Diagnostic_procedure:T126 
+T127	Diagnostic_procedure 2905 2909	CEUS
+E67	Diagnostic_procedure:T127 
+R68	IDENTICAL Arg1:E67 Arg2:E66	
+T128	Sign_symptom 2923 2940	abnormal residual
+E68	Sign_symptom:T128 
+T129	Biological_structure 2944 2980	proximal part of the pancreatic head
+R69	MODIFY Arg1:T129 Arg2:E68	
+T130	Clinical_event 3000 3009	follow-up
+E69	Clinical_event:T130 
+T131	Date 2994 2999	5-day
+E70	Date:T131 
+T132	Diagnostic_procedure 3028 3037	CT images
+E71	Diagnostic_procedure:T132 
+T133	Detailed_description 3010 3027	contrast-enhanced
+R70	MODIFY Arg1:T133 Arg2:E71	
+T134	Sign_symptom 3049 3053	mass
+E72	Sign_symptom:T134 
+T135	Detailed_description 3043 3048	lower
+R71	MODIFY Arg1:T135 Arg2:E72	
+T136	Sign_symptom 3062 3078	signal intensity
+E73	Sign_symptom:T136 
+T137	Severity 3058 3061	low
+R72	MODIFY Arg1:T137 Arg2:E73	
+T138	Sign_symptom 3089 3094	tumor
+E74	Sign_symptom:T138 
+T139	Detailed_description 3083 3088	upper
+R73	MODIFY Arg1:T139 Arg2:E74	
+T140	Sign_symptom 3122 3138	signal intensity
+E75	Sign_symptom:T140 
+T141	Severity 3104 3121	intermediate high
+R74	MODIFY Arg1:T141 Arg2:E75	
+T142	Detailed_description 3142 3169	residual in substance phase
+R75	MODIFY Arg1:T142 Arg2:E75	
+T143	Clinical_event 3207 3216	follow-up
+E76	Clinical_event:T143 
+T144	Date 3200 3206	1-week
+E77	Date:T144 
+T145	Diagnostic_procedure 3217 3221	CEUS
+E78	Diagnostic_procedure:T145 
+T146	Sign_symptom 3238 3246	enlarged
+E79	Sign_symptom:T146 
+T147	Biological_structure 3247 3262	retroperitoneal
+T148	Biological_structure 3263 3273	lymph node
+R76	MODIFY Arg1:T147 Arg2:T148	
+R77	MODIFY Arg1:T148 Arg2:E79	
+T149	Biological_structure 3282 3306	near the pancreatic head
+R78	MODIFY Arg1:T149 Arg2:T148	
+T150	Therapeutic_procedure 3409 3417	ablation
+E80	Therapeutic_procedure:T150 
+T151	Therapeutic_procedure 3425 3437	laser fibers
+E81	Therapeutic_procedure:T151 
+T152	Detailed_description 3423 3424	2
+R79	MODIFY Arg1:T152 Arg2:E81	
+R80	SUB_PROCEDURE Arg1:E81 Arg2:E80	
+T153	Sign_symptom 3449 3456	lesions
+E82	Sign_symptom:T153 
+T154	Sign_symptom 3470 3486	hyperechoic zone
+E83	Sign_symptom:T154 
+T155	Diagnostic_procedure 3533 3537	CEUS
+E84	Diagnostic_procedure:T155 
+T156	Diagnostic_procedure 3614 3616	MR
+E85	Diagnostic_procedure:T156 
+T157	Sign_symptom 3657 3662	tumor
+E86	Sign_symptom:T157 
+T158	Therapeutic_procedure 3693 3701	ablation
+E87	Therapeutic_procedure:T158 
+T159	Detailed_description 3687 3692	laser
+R81	MODIFY Arg1:T159 Arg2:E87	
+T160	Date 3510 3517	2nd day
+E88	Date:T160 
+#5	AnnotatorNotes E88	postoperative?
+T161	Date 3732 3744	3 days later
+E89	Date:T161 
+T162	Diagnostic_procedure 3745 3749	CEUS
+E90	Diagnostic_procedure:T162 
+T163	Sign_symptom 3785 3791	lesion
+E91	Sign_symptom:T163 
+T164	Severity 3779 3784	minor
+R82	MODIFY Arg1:T164 Arg2:E91	
+T165	Therapeutic_procedure 3887 3895	ablation
+E92	Therapeutic_procedure:T165 
+T166	Detailed_description 3405 3408	2nd
+R83	MODIFY Arg1:T166 Arg2:E80	
+T167	Detailed_description 3683 3686	3rd
+R84	MODIFY Arg1:T167 Arg2:E87	
+T168	Detailed_description 3883 3886	4th
+R85	MODIFY Arg1:T168 Arg2:E92	
+T169	Date 3965 3977	3 days later
+E93	Date:T169 
+T170	Diagnostic_procedure 4017 4019	CT
+E94	Diagnostic_procedure:T170 
+T171	Sign_symptom 4073 4081	necrosis
+E95	Sign_symptom:T171 
+T172	Sign_symptom 4049 4053	mass
+E96	Sign_symptom:T172 
+T173	Biological_structure 4033 4048	retroperitoneal
+R86	MODIFY Arg1:T173 Arg2:E96	
+R87	MODIFY Arg1:E96 Arg2:E94	
+T174	Date 4100 4127	After the following 1 month
+E97	Date:T174 
+T175	Diagnostic_procedure 4145 4147	MR
+E98	Diagnostic_procedure:T175 
+T176	Sign_symptom 4171 4195	signal of tumor necrosis
+E99	Sign_symptom:T176 
+T177	Date 4238 4252	Until 5 months
+E100	Date:T177 
+T178	Diagnostic_procedure 4272 4274	CT
+E101	Diagnostic_procedure:T178 
+T179	Sign_symptom 4286 4291	tumor
+E102	Sign_symptom:T179 
+*	OVERLAP E1 E2 E3
+R88	AFTER Arg1:E3 Arg2:E5	
+*	OVERLAP E5 E6
+R89	BEFORE Arg1:E5 Arg2:E7	
+*	OVERLAP E7 E8
+R90	BEFORE Arg1:E8 Arg2:E9	
+*	OVERLAP E9 E10 E11 E12 E13 E14
+R91	BEFORE Arg1:E14 Arg2:E15	
+*	OVERLAP E15 E16 E17
+R92	AFTER Arg1:E17 Arg2:E18	
+*	OVERLAP E18 E20 E22 E23 E24
+R93	BEFORE Arg1:E24 Arg2:E25	
+*	OVERLAP E25 E26 E27 E28 E29 E30 E31 E32
+R94	BEFORE Arg1:E32 Arg2:E36	
+*	OVERLAP E36 E37 E38 E40 E41 E43 E42 E45
+R95	BEFORE Arg1:E45 Arg2:E46	
+R96	AFTER Arg1:E46 Arg2:E47	
+*	OVERLAP E47 E48
+R97	BEFORE Arg1:E48 Arg2:E49	
+*	OVERLAP E49 E50 E51 E52 E53 E54 E60 E61 E62
+R98	BEFORE Arg1:E62 Arg2:E63	
+*	OVERLAP E63 E64 E65
+T180	Date 2866 2874	next day
+E103	Date:T180 
+R99	BEFORE Arg1:E65 Arg2:E103	
+*	OVERLAP E103 E66 E68
+R100	BEFORE Arg1:E68 Arg2:E70	
+*	OVERLAP E70 E69 E71 E72 E73 E74 E75
+R101	BEFORE Arg1:E75 Arg2:E77	
+*	OVERLAP E77 E76 E78 E79
+R102	BEFORE Arg1:E79 Arg2:E80	
+*	OVERLAP E80 E82 E83
+R103	BEFORE Arg1:E83 Arg2:E88	
+*	OVERLAP E88 E84 E104 E85 E86
+T181	Coreference 3552 3556	they
+E104	Coreference:T181 
+R104	IDENTICAL Arg1:E104 Arg2:E82	
+R105	BEFORE Arg1:E86 Arg2:E87	
+R106	BEFORE Arg1:E87 Arg2:E89	
+*	OVERLAP E89 E90 E91
+R107	BEFORE Arg1:E91 Arg2:E92	
+R108	BEFORE Arg1:E92 Arg2:E93	
+*	OVERLAP E93 E94 E96 E95
+R109	BEFORE Arg1:E95 Arg2:E97	
+*	OVERLAP E97 E98 E99 E105
+T182	Sign_symptom 4219 4227	problems
+E105	Sign_symptom:T182 
+A4	POLARITY E105 MAYBE_POS
+R110	BEFORE Arg1:E105 Arg2:E100	
+*	OVERLAP E100 E101 E102 E106 E56 E55
+T183	Sign_symptom 4316 4326	recurrence
+E106	Sign_symptom:T183 
+A5	POLARITY E106 MAYBE_NEG