a b/processing/MACCROBAT/28403099.ann
1
T1  Age 2 13    60-year-old
2
T2  Sex 14 17   man
3
T3  Clinical_event 18 27    presented
4
E1  Clinical_event:T3 
5
T4  Sign_symptom 51 61  metastatic
6
E2  Sign_symptom:T4 
7
T5  Biological_structure 62 72  lymph node
8
T6  Biological_structure 35 50  retroperitoneal
9
R1  MODIFY Arg1:T6 Arg2:E2  
10
R2  MODIFY Arg1:T5 Arg2:E2  
11
T7  Diagnostic_procedure 76 94  magnetic resonance
12
E3  Diagnostic_procedure:T7 
13
T8  Diagnostic_procedure 96 98  MR
14
E4  Diagnostic_procedure:T8 
15
R3  IDENTICAL Arg1:E4 Arg2:E3   
16
T9  Therapeutic_procedure 138 147   resection
17
E5  Therapeutic_procedure:T9 
18
T10 Date 151 155    2010
19
E6  Date:T10 
20
T11 Biological_structure 126 137    right liver
21
R4  MODIFY Arg1:T11 Arg2:E5 
22
T12 Therapeutic_procedure 173 182   resection
23
E7  Therapeutic_procedure:T12 
24
T13 Biological_structure 157 172    pulmonary wedge
25
R5  MODIFY Arg1:T13 Arg2:E7 
26
T14 Date 186 190    2012
27
E8  Date:T14 
28
R6  BEFORE Arg1:E8 Arg2:E7  
29
T15 Therapeutic_procedure 196 227   transarterial chemoembolization
30
E9  Therapeutic_procedure:T15 
31
T16 Detailed_description 228 233    twice
32
T17 Date 237 241    2014
33
E10 Date:T17 
34
R7  MODIFY Arg1:T16 Arg2:E9 
35
T18 History 126 155 right liver resection in 2010
36
T19 History 157 190 pulmonary wedge resection in 2012
37
T20 History 196 241 transarterial chemoembolization twice in 2014
38
T21 Diagnostic_procedure 270 279    pathology
39
E11 Diagnostic_procedure:T21 
40
T22 Disease_disorder 300 312    liver cancer
41
E12 Disease_disorder:T22 
42
A1  POLARITY E12 UNCERTAIN
43
T23 Detailed_description 294 299    mixed
44
R8  MODIFY Arg1:T23 Arg2:E12    
45
T24 Disease_disorder 340 351    lung cancer
46
E13 Disease_disorder:T24 
47
T25 Detailed_description 318 339    poorly differentiated
48
R9  MODIFY Arg1:T25 Arg2:E13    
49
T26 Sign_symptom 363 373    metastasis
50
E14 Sign_symptom:T26 
51
T27 Biological_structure 357 362    liver
52
R10 MODIFY Arg1:T27 Arg2:E14    
53
T28 Diagnostic_procedure 378 389    examination
54
E15 Diagnostic_procedure:T28 
55
T29 Coreference 395 400 tumor
56
E16 Coreference:T29 
57
R11 IDENTICAL Arg1:E16 Arg2:E2  
58
T30 Biological_structure 423 431    duodenum
59
T31 Biological_structure 433 441    pancreas
60
T32 Biological_structure 443 450    stomach
61
T33 Biological_structure 456 475    hepatic portal vein
62
R12 MODIFY Arg1:T30 Arg2:E16    
63
R13 MODIFY Arg1:T31 Arg2:E16    
64
R14 MODIFY Arg1:T32 Arg2:E16    
65
R15 MODIFY Arg1:T33 Arg2:E16    
66
T34 Sign_symptom 507 513    masses
67
E17 Sign_symptom:T34 
68
T35 Detailed_description 494 506    unresectable
69
R16 MODIFY Arg1:T35 Arg2:E17    
70
T36 History 518 544 hypertension over 10 years
71
T37 History 549 591 chronic HBV-related cirrhosis for 30 years
72
T38 Sign_symptom 518 530    hypertension
73
E18 Sign_symptom:T38 
74
T39 Duration 536 544    10 years
75
E19 Duration:T39 
76
R17 MODIFY Arg1:E19 Arg2:E18    
77
T40 Disease_disorder 557 578    HBV-related cirrhosis
78
E20 Disease_disorder:T40 
79
T41 Detailed_description 549 556    chronic
80
R18 MODIFY Arg1:T41 Arg2:E20    
81
T42 Duration 583 591    30 years
82
E21 Duration:T42 
83
R19 MODIFY Arg1:E21 Arg2:E20    
84
T43 Medication 617 627  lamivudine
85
E22 Medication:T43 
86
T44 Dosage 628 637  100 mg qd
87
R20 MODIFY Arg1:T44 Arg2:E22    
88
T45 Medication 643 661  adefovir dipivoxil
89
E23 Medication:T45 
90
T46 Dosage 662 670  10 mg qd
91
R21 MODIFY Arg1:T46 Arg2:E23    
92
T47 Duration 675 682    6 years
93
E24 Duration:T47 
94
R22 MODIFY Arg1:E24 Arg2:E23    
95
R23 MODIFY Arg1:E24 Arg2:E22    
96
T48 Diagnostic_procedure 703 719    body temperature
97
E25 Diagnostic_procedure:T48 
98
T49 Lab_value 694 702   constant
99
R24 MODIFY Arg1:T49 Arg2:E25    
100
T50 Lab_value 723 728   37 °C
101
R25 MODIFY Arg1:T50 Arg2:E25    
102
T51 Diagnostic_procedure 734 748    blood pressure
103
E26 Diagnostic_procedure:T51 
104
T52 Lab_value 752 764   148/96 mm Hg
105
R26 MODIFY Arg1:T52 Arg2:E26    
106
T53 Diagnostic_procedure 774 779    pulse
107
E27 Diagnostic_procedure:T53 
108
T54 Lab_value 783 804   77 beats every minute
109
R27 MODIFY Arg1:T54 Arg2:E27    
110
T55 Sign_symptom 852 856    pain
111
E28 Sign_symptom:T55 
112
A2  POLARITY E28 NEG
113
T56 Biological_structure 842 851    abdominal
114
T57 Biological_structure 858 867    abdominal
115
T58 Sign_symptom 868 878    distention
116
E29 Sign_symptom:T58 
117
T59 Sign_symptom 880 886    nausea
118
E30 Sign_symptom:T59 
119
T60 Sign_symptom 892 900    vomiting
120
E31 Sign_symptom:T60 
121
R28 MODIFY Arg1:T57 Arg2:E29    
122
R29 MODIFY Arg1:T56 Arg2:E28    
123
T61 Diagnostic_procedure 915 928    tumor markers
124
E32 Diagnostic_procedure:T61 
125
T62 Lab_value 954 960   normal
126
R30 MODIFY Arg1:T62 Arg2:E32    
127
T63 Diagnostic_procedure 975 999    carcinoembryonic antigen
128
E33 Diagnostic_procedure:T63 
129
T64 Diagnostic_procedure 1011 1028  alpha fetoprotein
130
E34 Diagnostic_procedure:T64 
131
T65 Diagnostic_procedure 1045 1070  carbohydrate antigen 19–9
132
E35 Diagnostic_procedure:T65 
133
T66 Lab_value 1000 1009 3.7 ng/mL
134
T67 Lab_value 1029 1039 17.3 ng/mL
135
T68 Lab_value 1078 1086 6.1 U/mL
136
R31 MODIFY Arg1:T68 Arg2:E35    
137
R32 SUB_PROCEDURE Arg1:E33 Arg2:E32 
138
R33 SUB_PROCEDURE Arg1:E34 Arg2:E32 
139
R34 SUB_PROCEDURE Arg1:E35 Arg2:E32 
140
T69 Therapeutic_procedure 1233 1241 ablation
141
E36 Therapeutic_procedure:T69 
142
T70 Detailed_description 1227 1232  local
143
R35 MODIFY Arg1:T70 Arg2:E36    
144
T71 Diagnostic_procedure 1261 1274  Choi criteria
145
E37 Diagnostic_procedure:T71 
146
T72 Diagnostic_procedure 1348 1367  computed tomography
147
E38 Diagnostic_procedure:T72 
148
T73 Diagnostic_procedure 1369 1371  CT
149
E39 Diagnostic_procedure:T73 
150
R36 IDENTICAL Arg1:E39 Arg2:E38 
151
T74 Other_entity 1382 1756  complete response, disappearance of all lesions and no new lesions; partial response (PR), a decrease in size of 10% or a decrease in tumor density over 15% on CT and no new lesions; stable disease, not fit for complete response, PR, or progressive disease; and progressive disease, an increase in tumor size over 10% and not fit for PR by tumor density on CT or new lesions
152
#1  AnnotatorNotes T74  This is just a description of the criteria
153
T75 Diagnostic_procedure 1775 1777  MR
154
E40 Diagnostic_procedure:T75 
155
T76 Sign_symptom 1800 1804  mass
156
E41 Sign_symptom:T76 
157
T77 Area 1808 1820  2.8 × 3.5 cm
158
R37 MODIFY Arg1:T77 Arg2:E41    
159
T78 Biological_structure 1842 1850  duodenum
160
T79 Biological_structure 1852 1860  pancreas
161
T80 Biological_structure 1866 1879  blood vessels
162
R38 MODIFY Arg1:T78 Arg2:E41    
163
R39 MODIFY Arg1:T79 Arg2:E41    
164
R40 MODIFY Arg1:T80 Arg2:E41    
165
T81 Sign_symptom 1946 1962  signal intensity
166
E42 Sign_symptom:T81 
167
T82 Diagnostic_procedure 1914 1916  MR
168
E43 Diagnostic_procedure:T82 
169
T83 Detailed_description 1897 1912  substance phase
170
R41 MODIFY Arg1:T83 Arg2:E43    
171
T84 Severity 1934 1945  mildly high
172
R42 MODIFY Arg1:T84 Arg2:E42    
173
T85 Coreference 1974 1979   tumor
174
E44 Coreference:T85 
175
R43 IDENTICAL Arg1:E44 Arg2:E41 
176
T86 Sign_symptom 2001 2017  signal intensity
177
E45 Sign_symptom:T86 
178
T87 Severity 1984 2000  intermediate low
179
R44 MODIFY Arg1:T87 Arg2:E45    
180
T88 Biological_structure 2025 2040  solid component
181
T89 Biological_structure 2052 2057  walls
182
R45 MODIFY Arg1:E44 Arg2:E42    
183
R46 MODIFY Arg1:T88 Arg2:E45    
184
R47 MODIFY Arg1:T89 Arg2:E45    
185
T90 Therapeutic_procedure 2087 2095 ablation
186
E46 Therapeutic_procedure:T90 
187
T91 Sign_symptom 2130 2146  hyperechoic area
188
E47 Sign_symptom:T91 
189
T92 Diagnostic_procedure 2156 2158  US
190
E48 Diagnostic_procedure:T92 
191
#2  AnnotatorNotes E48  ultrasound
192
T93 Detailed_description 2150 2155  axial
193
R48 MODIFY Arg1:T93 Arg2:E48    
194
T94 Severity 2125 2129  mild
195
T95 Biological_structure 2109 2124  retroperitoneal
196
R49 MODIFY Arg1:T95 Arg2:E47    
197
R50 MODIFY Arg1:T94 Arg2:E47    
198
T96 Diagnostic_procedure 2240 2248  biopsies
199
E49 Diagnostic_procedure:T96 
200
T97 Biological_structure 2227 2239  transhepatic
201
T98 Detailed_description 2214 2226  percutaneous
202
R51 MODIFY Arg1:T97 Arg2:E49    
203
R52 MODIFY Arg1:T98 Arg2:E49    
204
T99 Therapeutic_procedure 2253 2262 ablations
205
E50 Therapeutic_procedure:T99 
206
T100    Duration 2335 2351  about 40 minutes
207
E51 Duration:T100 
208
T101    Medication 2358 2374    local anesthesia
209
E52 Medication:T101 
210
T102    Medication 2384 2392    sedation
211
E53 Medication:T102 
212
T103    Diagnostic_procedure 2402 2417  ultrasonography
213
E54 Diagnostic_procedure:T103 
214
T104    Detailed_description 2421 2432  real-timely
215
#3  AnnotatorNotes T104 [sp]
216
R53 MODIFY Arg1:T104 Arg2:E54   
217
T105    Sign_symptom 4615 4627  side effects
218
E55 Sign_symptom:T105 
219
A3  POLARITY E55 NEG
220
T106    Diagnostic_procedure 4439 4452  tumor markers
221
E56 Diagnostic_procedure:T106 
222
T107    Diagnostic_procedure 4468 4492  carcinoembryonic antigen
223
E57 Diagnostic_procedure:T107 
224
T108    Diagnostic_procedure 4494 4511  alpha fetoprotein
225
E58 Diagnostic_procedure:T108 
226
T109    Diagnostic_procedure 4517 4542  carbohydrate antigen 19–9
227
E59 Diagnostic_procedure:T109 
228
T110    Lab_value 4553 4562 3.6 ng/mL
229
R54 MODIFY Arg1:T110 Arg2:E57   
230
T111    Lab_value 4564 4574 26.7 ng/mL
231
R55 MODIFY Arg1:T111 Arg2:E58   
232
T112    Lab_value 4580 4588 8.1 U/mL
233
R56 MODIFY Arg1:T112 Arg2:E59   
234
R57 SUB_PROCEDURE Arg1:E57 Arg2:E56 
235
R58 SUB_PROCEDURE Arg1:E58 Arg2:E56 
236
R59 SUB_PROCEDURE Arg1:E59 Arg2:E56 
237
T113    Therapeutic_procedure 2465 2477 laser fibers
238
E60 Therapeutic_procedure:T113 
239
R60 SUB_PROCEDURE Arg1:E60 Arg2:E50 
240
T114    Detailed_description 2456 2464  2 Nd:YAG
241
R61 MODIFY Arg1:T114 Arg2:E60   
242
T115    Detailed_description 2479 2506  Echolaser X4, ESAOTE, Italy
243
R62 MODIFY Arg1:T115 Arg2:E60   
244
T116    Detailed_description 2511 2526  0.3 mm diameter
245
T117    Detailed_description 2527 2557  through a 21-gauge Chiba needl
246
T118    Sign_symptom 2568 2575  lesions
247
E61 Sign_symptom:T118 
248
R63 MODIFY Arg1:T116 Arg2:E60   
249
R64 MODIFY Arg1:T117 Arg2:E60   
250
T119    Therapeutic_procedure 2639 2647 ablation
251
E62 Therapeutic_procedure:T119 
252
T120    Detailed_description 2665 2686  area from 12 to 15 mm
253
T121    Detailed_description 2696 2708  power of 5 W
254
T122    Detailed_description 2712 2726  5 to 6 minutes
255
R65 MODIFY Arg1:T120 Arg2:E62   
256
R66 MODIFY Arg1:T121 Arg2:E62   
257
#4  AnnotatorNotes T122 not a duration, but a function of the procedure
258
R67 MODIFY Arg1:T122 Arg2:E62   
259
T123    Diagnostic_procedure 2752 2767  ultrasonography
260
E63 Diagnostic_procedure:T123 
261
T124    Sign_symptom 2790 2796  lesion
262
E64 Sign_symptom:T124 
263
T125    Sign_symptom 2814 2830  hyperechoic zone
264
E65 Sign_symptom:T125 
265
T126    Diagnostic_procedure 2875 2903  contrast-enhanced ultrasound
266
E66 Diagnostic_procedure:T126 
267
T127    Diagnostic_procedure 2905 2909  CEUS
268
E67 Diagnostic_procedure:T127 
269
R68 IDENTICAL Arg1:E67 Arg2:E66 
270
T128    Sign_symptom 2923 2940  abnormal residual
271
E68 Sign_symptom:T128 
272
T129    Biological_structure 2944 2980  proximal part of the pancreatic head
273
R69 MODIFY Arg1:T129 Arg2:E68   
274
T130    Clinical_event 3000 3009    follow-up
275
E69 Clinical_event:T130 
276
T131    Date 2994 2999  5-day
277
E70 Date:T131 
278
T132    Diagnostic_procedure 3028 3037  CT images
279
E71 Diagnostic_procedure:T132 
280
T133    Detailed_description 3010 3027  contrast-enhanced
281
R70 MODIFY Arg1:T133 Arg2:E71   
282
T134    Sign_symptom 3049 3053  mass
283
E72 Sign_symptom:T134 
284
T135    Detailed_description 3043 3048  lower
285
R71 MODIFY Arg1:T135 Arg2:E72   
286
T136    Sign_symptom 3062 3078  signal intensity
287
E73 Sign_symptom:T136 
288
T137    Severity 3058 3061  low
289
R72 MODIFY Arg1:T137 Arg2:E73   
290
T138    Sign_symptom 3089 3094  tumor
291
E74 Sign_symptom:T138 
292
T139    Detailed_description 3083 3088  upper
293
R73 MODIFY Arg1:T139 Arg2:E74   
294
T140    Sign_symptom 3122 3138  signal intensity
295
E75 Sign_symptom:T140 
296
T141    Severity 3104 3121  intermediate high
297
R74 MODIFY Arg1:T141 Arg2:E75   
298
T142    Detailed_description 3142 3169  residual in substance phase
299
R75 MODIFY Arg1:T142 Arg2:E75   
300
T143    Clinical_event 3207 3216    follow-up
301
E76 Clinical_event:T143 
302
T144    Date 3200 3206  1-week
303
E77 Date:T144 
304
T145    Diagnostic_procedure 3217 3221  CEUS
305
E78 Diagnostic_procedure:T145 
306
T146    Sign_symptom 3238 3246  enlarged
307
E79 Sign_symptom:T146 
308
T147    Biological_structure 3247 3262  retroperitoneal
309
T148    Biological_structure 3263 3273  lymph node
310
R76 MODIFY Arg1:T147 Arg2:T148  
311
R77 MODIFY Arg1:T148 Arg2:E79   
312
T149    Biological_structure 3282 3306  near the pancreatic head
313
R78 MODIFY Arg1:T149 Arg2:T148  
314
T150    Therapeutic_procedure 3409 3417 ablation
315
E80 Therapeutic_procedure:T150 
316
T151    Therapeutic_procedure 3425 3437 laser fibers
317
E81 Therapeutic_procedure:T151 
318
T152    Detailed_description 3423 3424  2
319
R79 MODIFY Arg1:T152 Arg2:E81   
320
R80 SUB_PROCEDURE Arg1:E81 Arg2:E80 
321
T153    Sign_symptom 3449 3456  lesions
322
E82 Sign_symptom:T153 
323
T154    Sign_symptom 3470 3486  hyperechoic zone
324
E83 Sign_symptom:T154 
325
T155    Diagnostic_procedure 3533 3537  CEUS
326
E84 Diagnostic_procedure:T155 
327
T156    Diagnostic_procedure 3614 3616  MR
328
E85 Diagnostic_procedure:T156 
329
T157    Sign_symptom 3657 3662  tumor
330
E86 Sign_symptom:T157 
331
T158    Therapeutic_procedure 3693 3701 ablation
332
E87 Therapeutic_procedure:T158 
333
T159    Detailed_description 3687 3692  laser
334
R81 MODIFY Arg1:T159 Arg2:E87   
335
T160    Date 3510 3517  2nd day
336
E88 Date:T160 
337
#5  AnnotatorNotes E88  postoperative?
338
T161    Date 3732 3744  3 days later
339
E89 Date:T161 
340
T162    Diagnostic_procedure 3745 3749  CEUS
341
E90 Diagnostic_procedure:T162 
342
T163    Sign_symptom 3785 3791  lesion
343
E91 Sign_symptom:T163 
344
T164    Severity 3779 3784  minor
345
R82 MODIFY Arg1:T164 Arg2:E91   
346
T165    Therapeutic_procedure 3887 3895 ablation
347
E92 Therapeutic_procedure:T165 
348
T166    Detailed_description 3405 3408  2nd
349
R83 MODIFY Arg1:T166 Arg2:E80   
350
T167    Detailed_description 3683 3686  3rd
351
R84 MODIFY Arg1:T167 Arg2:E87   
352
T168    Detailed_description 3883 3886  4th
353
R85 MODIFY Arg1:T168 Arg2:E92   
354
T169    Date 3965 3977  3 days later
355
E93 Date:T169 
356
T170    Diagnostic_procedure 4017 4019  CT
357
E94 Diagnostic_procedure:T170 
358
T171    Sign_symptom 4073 4081  necrosis
359
E95 Sign_symptom:T171 
360
T172    Sign_symptom 4049 4053  mass
361
E96 Sign_symptom:T172 
362
T173    Biological_structure 4033 4048  retroperitoneal
363
R86 MODIFY Arg1:T173 Arg2:E96   
364
R87 MODIFY Arg1:E96 Arg2:E94    
365
T174    Date 4100 4127  After the following 1 month
366
E97 Date:T174 
367
T175    Diagnostic_procedure 4145 4147  MR
368
E98 Diagnostic_procedure:T175 
369
T176    Sign_symptom 4171 4195  signal of tumor necrosis
370
E99 Sign_symptom:T176 
371
T177    Date 4238 4252  Until 5 months
372
E100    Date:T177 
373
T178    Diagnostic_procedure 4272 4274  CT
374
E101    Diagnostic_procedure:T178 
375
T179    Sign_symptom 4286 4291  tumor
376
E102    Sign_symptom:T179 
377
*   OVERLAP E1 E2 E3
378
R88 AFTER Arg1:E3 Arg2:E5   
379
*   OVERLAP E5 E6
380
R89 BEFORE Arg1:E5 Arg2:E7  
381
*   OVERLAP E7 E8
382
R90 BEFORE Arg1:E8 Arg2:E9  
383
*   OVERLAP E9 E10 E11 E12 E13 E14
384
R91 BEFORE Arg1:E14 Arg2:E15    
385
*   OVERLAP E15 E16 E17
386
R92 AFTER Arg1:E17 Arg2:E18 
387
*   OVERLAP E18 E20 E22 E23 E24
388
R93 BEFORE Arg1:E24 Arg2:E25    
389
*   OVERLAP E25 E26 E27 E28 E29 E30 E31 E32
390
R94 BEFORE Arg1:E32 Arg2:E36    
391
*   OVERLAP E36 E37 E38 E40 E41 E43 E42 E45
392
R95 BEFORE Arg1:E45 Arg2:E46    
393
R96 AFTER Arg1:E46 Arg2:E47 
394
*   OVERLAP E47 E48
395
R97 BEFORE Arg1:E48 Arg2:E49    
396
*   OVERLAP E49 E50 E51 E52 E53 E54 E60 E61 E62
397
R98 BEFORE Arg1:E62 Arg2:E63    
398
*   OVERLAP E63 E64 E65
399
T180    Date 2866 2874  next day
400
E103    Date:T180 
401
R99 BEFORE Arg1:E65 Arg2:E103   
402
*   OVERLAP E103 E66 E68
403
R100    BEFORE Arg1:E68 Arg2:E70    
404
*   OVERLAP E70 E69 E71 E72 E73 E74 E75
405
R101    BEFORE Arg1:E75 Arg2:E77    
406
*   OVERLAP E77 E76 E78 E79
407
R102    BEFORE Arg1:E79 Arg2:E80    
408
*   OVERLAP E80 E82 E83
409
R103    BEFORE Arg1:E83 Arg2:E88    
410
*   OVERLAP E88 E84 E104 E85 E86
411
T181    Coreference 3552 3556   they
412
E104    Coreference:T181 
413
R104    IDENTICAL Arg1:E104 Arg2:E82    
414
R105    BEFORE Arg1:E86 Arg2:E87    
415
R106    BEFORE Arg1:E87 Arg2:E89    
416
*   OVERLAP E89 E90 E91
417
R107    BEFORE Arg1:E91 Arg2:E92    
418
R108    BEFORE Arg1:E92 Arg2:E93    
419
*   OVERLAP E93 E94 E96 E95
420
R109    BEFORE Arg1:E95 Arg2:E97    
421
*   OVERLAP E97 E98 E99 E105
422
T182    Sign_symptom 4219 4227  problems
423
E105    Sign_symptom:T182 
424
A4  POLARITY E105 MAYBE_POS
425
R110    BEFORE Arg1:E105 Arg2:E100  
426
*   OVERLAP E100 E101 E102 E106 E56 E55
427
T183    Sign_symptom 4316 4326  recurrence
428
E106    Sign_symptom:T183 
429
A5  POLARITY E106 MAYBE_NEG