T1  Date 0 7    In 2013

E1  Date:T1 

T2  Age 11 22   50-year-old

T3  Sex 23 26   man

T4  Clinical_event 35 42    visited

E2  Clinical_event:T4 

T5  Nonbiological_location 43 51    hospital

T6  Sign_symptom 78 82  pain

E3  Sign_symptom:T6 

T7  Biological_structure 73 77  bone

T8  Biological_structure 90 98  left leg

T9  Detailed_description 67 72  local

R1  MODIFY Arg1:T8 Arg2:E3  

R2  MODIFY Arg1:T7 Arg2:E3  

R3  MODIFY Arg1:T9 Arg2:E3  

T10 Date 103 118    August 14, 2013

E4  Date:T10 

T11 Disease_disorder 292 304    osteosarcoma

E5  Disease_disorder:T11 

T12 Detailed_description 279 291    osteoblastic

R4  MODIFY Arg1:T12 Arg2:E5 

T13 Therapeutic_procedure 178 187   resection

E6  Therapeutic_procedure:T13 

T14 Detailed_description 170 177    en bloc

R5  MODIFY Arg1:T14 Arg2:E6 

T15 Sign_symptom 164 169    tumor

E7  Sign_symptom:T15 

T16 Biological_structure 144 163    left distal femoral

R6  MODIFY Arg1:T16 Arg2:E7 

T17 Therapeutic_procedure 192 206   reconstruction

E8  Therapeutic_procedure:T17 

T18 Detailed_description 214 247    modular femoral prosthetic system

R7  MODIFY Arg1:T18 Arg2:E8 

T19 Diagnostic_procedure 249 268    Pathology diagnosis

E9  Diagnostic_procedure:T19 

T20 Medication 339 351  chemotherapy

E10 Medication:T20 

T21 Detailed_description 327 338    neoadjuvant

R8  MODIFY Arg1:T21 Arg2:E10    

T22 Dosage 314 323  One cycle

R9  MODIFY Arg1:T22 Arg2:E10    

T23 Dosage 356 364  4 cycles

T24 Detailed_description 368 376    adjuvant

T25 Medication 377 389  chemotherapy

E11 Medication:T25 

R10 MODIFY Arg1:T24 Arg2:E11    

R11 MODIFY Arg1:T23 Arg2:E11    

T26 Medication 395 406  MAP regimen

E12 Medication:T26 

T27 Medication 418 430  methotrexate

E13 Medication:T27 

T28 Dosage 408 417  high-dose

R12 MODIFY Arg1:T28 Arg2:E13    

R13 SUB_PROCEDURE Arg1:E13 Arg2:E12 

T29 Medication 432 441  cisplatin

E14 Medication:T29 

T30 Medication 447 458  doxorubicin

E15 Medication:T30 

R14 SUB_PROCEDURE Arg1:E14 Arg2:E12 

R15 SUB_PROCEDURE Arg1:E15 Arg2:E12 

T31 Date 482 494    January 2015

E16 Date:T31 

T32 Sign_symptom 498 502    mass

E17 Sign_symptom:T32 

T33 Biological_structure 520 540    left upper crus area

R16 MODIFY Arg1:T33 Arg2:E17    

T34 Sign_symptom 548 558    recurrence

E18 Sign_symptom:T34 

T35 Diagnostic_procedure 576 582    biopsy

E19 Diagnostic_procedure:T35 

T36 Date 586 602    January 23, 2015

E20 Date:T36 

T37 Therapeutic_procedure 633 643   amputation

E21 Therapeutic_procedure:T37 

T38 Biological_structure 621 632    upper femur

R17 MODIFY Arg1:T38 Arg2:E21    

T39 Therapeutic_procedure 688 705   joint replacement

E22 Therapeutic_procedure:T39 

A1  POLARITY E22 NEG

T40 Biological_structure 684 687    hip

R18 MODIFY Arg1:T40 Arg2:E22    

T41 Therapeutic_procedure 713 726   wound healing

E23 Therapeutic_procedure:T41 

T42 Clinical_event 740 768  went back to his normal life

E24 Clinical_event:T42 

T44 Therapeutic_procedure 784 799   artificial limb

E25 Therapeutic_procedure:T44 

#1  AnnotatorNotes E25  not a therapy per se

T45 Medication 832 844  chemotherapy

E26 Medication:T45 

A2  POLARITY E26 NEG

T46 Date 967 984    half a year after

E27 Date:T46 

T47 Sign_symptom 1028 1033  cough

E28 Sign_symptom:T47 

T48 Sign_symptom 1044 1053  tightness

E29 Sign_symptom:T48 

T49 Biological_structure 1038 1043  chest

T50 Detailed_description 1017 1027  occasional

R20 MODIFY Arg1:T50 Arg2:E28    

R21 MODIFY Arg1:T49 Arg2:E29    

T51 Diagnostic_procedure 1073 1092  computed tomography

E30 Diagnostic_procedure:T51 

T52 Diagnostic_procedure 1094 1096  CT

E31 Diagnostic_procedure:T52 

T53 Biological_structure 1067 1072  chest

T54 Detailed_description 1062 1066  thin

R22 MODIFY Arg1:T53 Arg2:E30    

R23 MODIFY Arg1:T54 Arg2:E30    

R24 IDENTICAL Arg1:E31 Arg2:E30 

T55 Date 1115 1128  July 15, 2015

E32 Date:T55 

T56 Sign_symptom 1173 1180  nodules

E33 Sign_symptom:T56 

T57 Biological_structure 1163 1172  pulmonary

T58 Detailed_description 1154 1162  multiple

R25 MODIFY Arg1:T57 Arg2:E33    

R26 MODIFY Arg1:T58 Arg2:E33    

T59 Sign_symptom 1224 1234  metastases

E34 Sign_symptom:T59 

A3  POLARITY E34 UNCERTAIN

T60 Medication 1271 1283    chemotherapy

E35 Medication:T60 

A4  POLARITY E35 NEG

T61 Diagnostic_procedure 1285 1300  Immunophenotype

E36 Diagnostic_procedure:T61 

T62 Sign_symptom 1335 1340  tumor

E37 Sign_symptom:T62 

T63 Detailed_description 1329 1334  CD34+

T64 Detailed_description 1319 1324  CD31+

R27 MODIFY Arg1:T63 Arg2:E37    

R28 MODIFY Arg1:T64 Arg2:E37    

T65 Coreference 1374 1379   cells

E38 Coreference:T65 

R29 IDENTICAL Arg1:E38 Arg2:E37 

T66 Diagnostic_procedure 1403 1423  staining for VEGFR-2

E39 Diagnostic_procedure:T66 

T67 Lab_value 1387 1402 strong positive

R30 MODIFY Arg1:T67 Arg2:E39    

R31 MODIFY Arg1:E38 Arg2:E39    

T68 Medication 1433 1441    Apatinib

E40 Medication:T68 

T69 Dosage 1472 1484    500 mg daily

R32 MODIFY Arg1:T69 Arg2:E40    

T70 Activity 3025 3032  driving

E41 Activity:T70 

T71 Date 1486 1504  Half a month later

E42 Date:T71 

T72 Sign_symptom 1510 1518  symptoms

E43 Sign_symptom:T72 

A5  POLARITY E43 NEG

T73 Sign_symptom 1550 1564  wound necrosis

E44 Sign_symptom:T73 

T74 Detailed_description 1538 1549  progressive

R33 MODIFY Arg1:T74 Arg2:E44    

T75 Therapeutic_procedure 1577 1596 debridement surgery

E45 Therapeutic_procedure:T75 

T76 Therapeutic_procedure 1669 1677 resected

E46 Therapeutic_procedure:T76 

T77 Sign_symptom 1626 1634  enlarged

E47 Sign_symptom:T77 

T78 Biological_structure 1635 1645  lymph node

R34 MODIFY Arg1:T78 Arg2:E47    

T79 Biological_structure 1646 1664  near iliac vessels

R35 MODIFY Arg1:T79 Arg2:T78    

T80 Date 1681 1698  February 24, 2016

E48 Date:T80 

R36 MODIFY Arg1:T78 Arg2:E46    

T81 Diagnostic_procedure 1730 1754  pathological examination

E49 Diagnostic_procedure:T81 

T82 Sign_symptom 1780 1791  hyperplasia

E50 Sign_symptom:T82 

T83 Detailed_description 1767 1779  inflammatory

R37 MODIFY Arg1:T83 Arg2:E50    

T84 Biological_structure 1792 1802  lymph node

R38 MODIFY Arg1:T84 Arg2:E50    

T85 Medication 1804 1812    Apatinib

E51 Medication:T85 

A6  POLARITY E51 NEG

T86 Duration 1851 1858  3 weeks

E52 Duration:T86 

T87 Therapeutic_procedure 1862 1875 wound healing

E53 Therapeutic_procedure:T87 

T88 Diagnostic_procedure 1899 1901  CT

E54 Diagnostic_procedure:T88 

T89 Biological_structure 1893 1898  chest

T90 Detailed_description 1888 1892  thin

R39 MODIFY Arg1:T89 Arg2:E54    

R40 MODIFY Arg1:T90 Arg2:E54    

T91 Date 1916 1931  7 and 11 months

E55 Date:T91 

T92 Clinical_event 1982 1991    follow-up

E56 Clinical_event:T92 

T93 Date 1974 1981  7-month

E57 Date:T93 

T94 Lab_value 2658 2660 PR

#2  AnnotatorNotes T94  partial response

T95 Diagnostic_procedure 2581 2592  measurement

E58 Diagnostic_procedure:T95 

T96 Detailed_description 2574 2580  lesion

R41 MODIFY Arg1:T96 Arg2:E58    

T97 Diagnostic_procedure 2610 2629  RECIST 1.1 standard

E59 Diagnostic_procedure:T97 

R42 SUB_PROCEDURE Arg1:E59 Arg2:E58 

R43 MODIFY Arg1:T94 Arg2:E59    

T98 Disease_disorder 2715 2733  hand-foot syndrome

E60 Disease_disorder:T98 

T99 Severity 2710 2714  mild

R44 MODIFY Arg1:T99 Arg2:E60    

T100    Sign_symptom 2745 2764  high blood pressure

E61 Sign_symptom:T100 

T101    Severity 2738 2744  slight

R45 MODIFY Arg1:T101 Arg2:E61   

T102    Lab_value 2776 2819 well controlled after appropriate treatment

R46 MODIFY Arg1:T102 Arg2:E60   

R47 MODIFY Arg1:T102 Arg2:E61   

T103    Sign_symptom 2831 2841  toxicities

E62 Sign_symptom:T103 

A7  POLARITY E62 NEG

T104    Sign_symptom 2870 2884  adverse events

E63 Sign_symptom:T104 

A8  POLARITY E63 NEG

T105    Severity 2824 2830  severe

R48 MODIFY Arg1:T105 Arg2:E62   

T106    Detailed_description 2852 2869  treatment-related

R49 MODIFY Arg1:T106 Arg2:E63   

T107    Medication 2929 2937    apatinib

E64 Medication:T107 

T108    Sign_symptom 2975 2988  toxic effects

E65 Sign_symptom:T108 

A9  POLARITY E65 NEG

T109    Clinical_event 2994 3018    went back to normal life

E66 Clinical_event:T109 

T111    Detailed_description 3036 3049  automatic car

#3  AnnotatorNotes T111 why is this relevant

R51 MODIFY Arg1:T111 Arg2:E41   

T112    Sign_symptom 2057 2064  lesions

E67 Sign_symptom:T112 

A10 POLARITY E67 NEG

T113    Lab_value 2004 2025 2 out of 5 measurable

T114    Lab_value 2030 2056 9 out of 17 non-measurable

R52 MODIFY Arg1:T114 Arg2:E67   

R53 MODIFY Arg1:T113 Arg2:E67   

T115    Sign_symptom 2099 2105  nodule

E68 Sign_symptom:T115 

T116    Sign_symptom 2131 2138  lesions

E69 Sign_symptom:T116 

T117    Lab_value 2082 2098 1 new measurable

R54 MODIFY Arg1:T117 Arg2:E68   

T118    Lab_value 2110 2130 6 new non-measurable

R55 MODIFY Arg1:T118 Arg2:E69   

T119    Diagnostic_procedure 2209 2253  Response Evaluation Criteria in Solid Tumors

E70 Diagnostic_procedure:T119 

T120    Diagnostic_procedure 2255 2261  RECIST

E71 Diagnostic_procedure:T120 

R56 IDENTICAL Arg1:E71 Arg2:E70 

T121    Detailed_description 2263 2266  1.1

R57 MODIFY Arg1:T121 Arg2:E70   

T122    Lab_value 2189 2191 PD

R58 MODIFY Arg1:T122 Arg2:E70   

T123    Clinical_event 2302 2311    follow-up

E72 Clinical_event:T123 

T124    Date 2293 2301  11-month

E73 Date:T124 

T125    Sign_symptom 2337 2344  lesions

E74 Sign_symptom:T125 

A11 POLARITY E74 NEG

T126    Lab_value 2335 2336 9

R59 MODIFY Arg1:T126 Arg2:E74   

T127    Lab_value 2368 2387 1 measurable nodule

R60 MODIFY Arg1:T127 Arg2:E74   

T128    Lab_value 2392 2416 2 non-measurable lesions

R61 MODIFY Arg1:T128 Arg2:E74   

T129    Lab_value 2464 2489 6 non-measureable lesions

R62 MODIFY Arg1:T129 Arg2:E74   

R63 MODIFY Arg1:T5 Arg2:E2  

*   OVERLAP E1 E2 E3

R64 BEFORE Arg1:E3 Arg2:E4  

*   OVERLAP E4 E7 E6 E8 E9 E5

R65 BEFORE Arg1:E5 Arg2:E10 

*   OVERLAP E10 E11 E12

R66 BEFORE Arg1:E12 Arg2:E16    

*   OVERLAP E16 E17

R67 BEFORE Arg1:E17 Arg2:E18    

*   OVERLAP E18 E19 E20

R68 BEFORE Arg1:E20 Arg2:E21    

*   OVERLAP E21 E22

R69 BEFORE Arg1:E22 Arg2:E23    

R70 BEFORE Arg1:E23 Arg2:E24    

*   OVERLAP E24 E25 E26

R71 BEFORE Arg1:E26 Arg2:E27    

*   OVERLAP E27 E28 E29

R72 BEFORE Arg1:E29 Arg2:E30    

*   OVERLAP E30 E32 E33 E34 E35 E36 E37 E38 E39

R73 BEFORE Arg1:E39 Arg2:E40    

R74 BEFORE Arg1:E40 Arg2:E42    

*   OVERLAP E42 E43 E44

R75 BEFORE Arg1:E44 Arg2:E45    

*   OVERLAP E45 E47 E46 E48 E49 E50

R76 BEFORE Arg1:E50 Arg2:E51    

*   OVERLAP E51 E52 E53

R77 BEFORE Arg1:E53 Arg2:E54    

*   OVERLAP E54 E55 E57 E56 E67 E68 E69 E70

R78 BEFORE Arg1:E70 Arg2:E73    

*   OVERLAP E73 E72 E74 E58 E60 E61 E62 E63

R79 BEFORE Arg1:E63 Arg2:E64    

*   OVERLAP E64 E65 E66 E41