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b/processing/MACCROBAT/28403086.ann |
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1 |
T1 Date 0 7 In 2013 |
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2 |
E1 Date:T1 |
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3 |
T2 Age 11 22 50-year-old |
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4 |
T3 Sex 23 26 man |
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5 |
T4 Clinical_event 35 42 visited |
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6 |
E2 Clinical_event:T4 |
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7 |
T5 Nonbiological_location 43 51 hospital |
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8 |
T6 Sign_symptom 78 82 pain |
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9 |
E3 Sign_symptom:T6 |
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10 |
T7 Biological_structure 73 77 bone |
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11 |
T8 Biological_structure 90 98 left leg |
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12 |
T9 Detailed_description 67 72 local |
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13 |
R1 MODIFY Arg1:T8 Arg2:E3 |
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14 |
R2 MODIFY Arg1:T7 Arg2:E3 |
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15 |
R3 MODIFY Arg1:T9 Arg2:E3 |
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16 |
T10 Date 103 118 August 14, 2013 |
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17 |
E4 Date:T10 |
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18 |
T11 Disease_disorder 292 304 osteosarcoma |
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E5 Disease_disorder:T11 |
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T12 Detailed_description 279 291 osteoblastic |
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21 |
R4 MODIFY Arg1:T12 Arg2:E5 |
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22 |
T13 Therapeutic_procedure 178 187 resection |
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23 |
E6 Therapeutic_procedure:T13 |
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24 |
T14 Detailed_description 170 177 en bloc |
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R5 MODIFY Arg1:T14 Arg2:E6 |
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26 |
T15 Sign_symptom 164 169 tumor |
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27 |
E7 Sign_symptom:T15 |
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T16 Biological_structure 144 163 left distal femoral |
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R6 MODIFY Arg1:T16 Arg2:E7 |
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30 |
T17 Therapeutic_procedure 192 206 reconstruction |
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31 |
E8 Therapeutic_procedure:T17 |
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32 |
T18 Detailed_description 214 247 modular femoral prosthetic system |
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R7 MODIFY Arg1:T18 Arg2:E8 |
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34 |
T19 Diagnostic_procedure 249 268 Pathology diagnosis |
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35 |
E9 Diagnostic_procedure:T19 |
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36 |
T20 Medication 339 351 chemotherapy |
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37 |
E10 Medication:T20 |
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38 |
T21 Detailed_description 327 338 neoadjuvant |
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R8 MODIFY Arg1:T21 Arg2:E10 |
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T22 Dosage 314 323 One cycle |
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R9 MODIFY Arg1:T22 Arg2:E10 |
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42 |
T23 Dosage 356 364 4 cycles |
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43 |
T24 Detailed_description 368 376 adjuvant |
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T25 Medication 377 389 chemotherapy |
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45 |
E11 Medication:T25 |
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R10 MODIFY Arg1:T24 Arg2:E11 |
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R11 MODIFY Arg1:T23 Arg2:E11 |
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48 |
T26 Medication 395 406 MAP regimen |
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49 |
E12 Medication:T26 |
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T27 Medication 418 430 methotrexate |
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51 |
E13 Medication:T27 |
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T28 Dosage 408 417 high-dose |
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R12 MODIFY Arg1:T28 Arg2:E13 |
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54 |
R13 SUB_PROCEDURE Arg1:E13 Arg2:E12 |
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55 |
T29 Medication 432 441 cisplatin |
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56 |
E14 Medication:T29 |
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T30 Medication 447 458 doxorubicin |
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E15 Medication:T30 |
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R14 SUB_PROCEDURE Arg1:E14 Arg2:E12 |
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R15 SUB_PROCEDURE Arg1:E15 Arg2:E12 |
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61 |
T31 Date 482 494 January 2015 |
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E16 Date:T31 |
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63 |
T32 Sign_symptom 498 502 mass |
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E17 Sign_symptom:T32 |
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T33 Biological_structure 520 540 left upper crus area |
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R16 MODIFY Arg1:T33 Arg2:E17 |
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67 |
T34 Sign_symptom 548 558 recurrence |
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68 |
E18 Sign_symptom:T34 |
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69 |
T35 Diagnostic_procedure 576 582 biopsy |
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70 |
E19 Diagnostic_procedure:T35 |
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T36 Date 586 602 January 23, 2015 |
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72 |
E20 Date:T36 |
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T37 Therapeutic_procedure 633 643 amputation |
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E21 Therapeutic_procedure:T37 |
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T38 Biological_structure 621 632 upper femur |
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R17 MODIFY Arg1:T38 Arg2:E21 |
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T39 Therapeutic_procedure 688 705 joint replacement |
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E22 Therapeutic_procedure:T39 |
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A1 POLARITY E22 NEG |
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T40 Biological_structure 684 687 hip |
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R18 MODIFY Arg1:T40 Arg2:E22 |
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82 |
T41 Therapeutic_procedure 713 726 wound healing |
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E23 Therapeutic_procedure:T41 |
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T42 Clinical_event 740 768 went back to his normal life |
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E24 Clinical_event:T42 |
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T44 Therapeutic_procedure 784 799 artificial limb |
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E25 Therapeutic_procedure:T44 |
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#1 AnnotatorNotes E25 not a therapy per se |
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T45 Medication 832 844 chemotherapy |
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90 |
E26 Medication:T45 |
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A2 POLARITY E26 NEG |
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92 |
T46 Date 967 984 half a year after |
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93 |
E27 Date:T46 |
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T47 Sign_symptom 1028 1033 cough |
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E28 Sign_symptom:T47 |
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T48 Sign_symptom 1044 1053 tightness |
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E29 Sign_symptom:T48 |
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T49 Biological_structure 1038 1043 chest |
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T50 Detailed_description 1017 1027 occasional |
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R20 MODIFY Arg1:T50 Arg2:E28 |
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R21 MODIFY Arg1:T49 Arg2:E29 |
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102 |
T51 Diagnostic_procedure 1073 1092 computed tomography |
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103 |
E30 Diagnostic_procedure:T51 |
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104 |
T52 Diagnostic_procedure 1094 1096 CT |
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105 |
E31 Diagnostic_procedure:T52 |
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T53 Biological_structure 1067 1072 chest |
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107 |
T54 Detailed_description 1062 1066 thin |
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108 |
R22 MODIFY Arg1:T53 Arg2:E30 |
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R23 MODIFY Arg1:T54 Arg2:E30 |
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110 |
R24 IDENTICAL Arg1:E31 Arg2:E30 |
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111 |
T55 Date 1115 1128 July 15, 2015 |
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112 |
E32 Date:T55 |
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113 |
T56 Sign_symptom 1173 1180 nodules |
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114 |
E33 Sign_symptom:T56 |
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T57 Biological_structure 1163 1172 pulmonary |
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116 |
T58 Detailed_description 1154 1162 multiple |
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117 |
R25 MODIFY Arg1:T57 Arg2:E33 |
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118 |
R26 MODIFY Arg1:T58 Arg2:E33 |
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119 |
T59 Sign_symptom 1224 1234 metastases |
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120 |
E34 Sign_symptom:T59 |
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121 |
A3 POLARITY E34 UNCERTAIN |
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122 |
T60 Medication 1271 1283 chemotherapy |
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123 |
E35 Medication:T60 |
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124 |
A4 POLARITY E35 NEG |
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125 |
T61 Diagnostic_procedure 1285 1300 Immunophenotype |
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126 |
E36 Diagnostic_procedure:T61 |
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127 |
T62 Sign_symptom 1335 1340 tumor |
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128 |
E37 Sign_symptom:T62 |
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129 |
T63 Detailed_description 1329 1334 CD34+ |
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130 |
T64 Detailed_description 1319 1324 CD31+ |
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131 |
R27 MODIFY Arg1:T63 Arg2:E37 |
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132 |
R28 MODIFY Arg1:T64 Arg2:E37 |
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133 |
T65 Coreference 1374 1379 cells |
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134 |
E38 Coreference:T65 |
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135 |
R29 IDENTICAL Arg1:E38 Arg2:E37 |
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136 |
T66 Diagnostic_procedure 1403 1423 staining for VEGFR-2 |
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137 |
E39 Diagnostic_procedure:T66 |
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138 |
T67 Lab_value 1387 1402 strong positive |
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139 |
R30 MODIFY Arg1:T67 Arg2:E39 |
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140 |
R31 MODIFY Arg1:E38 Arg2:E39 |
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141 |
T68 Medication 1433 1441 Apatinib |
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142 |
E40 Medication:T68 |
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143 |
T69 Dosage 1472 1484 500 mg daily |
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144 |
R32 MODIFY Arg1:T69 Arg2:E40 |
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145 |
T70 Activity 3025 3032 driving |
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146 |
E41 Activity:T70 |
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147 |
T71 Date 1486 1504 Half a month later |
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148 |
E42 Date:T71 |
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149 |
T72 Sign_symptom 1510 1518 symptoms |
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150 |
E43 Sign_symptom:T72 |
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151 |
A5 POLARITY E43 NEG |
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152 |
T73 Sign_symptom 1550 1564 wound necrosis |
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153 |
E44 Sign_symptom:T73 |
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154 |
T74 Detailed_description 1538 1549 progressive |
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155 |
R33 MODIFY Arg1:T74 Arg2:E44 |
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156 |
T75 Therapeutic_procedure 1577 1596 debridement surgery |
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157 |
E45 Therapeutic_procedure:T75 |
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158 |
T76 Therapeutic_procedure 1669 1677 resected |
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159 |
E46 Therapeutic_procedure:T76 |
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160 |
T77 Sign_symptom 1626 1634 enlarged |
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161 |
E47 Sign_symptom:T77 |
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162 |
T78 Biological_structure 1635 1645 lymph node |
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163 |
R34 MODIFY Arg1:T78 Arg2:E47 |
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164 |
T79 Biological_structure 1646 1664 near iliac vessels |
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165 |
R35 MODIFY Arg1:T79 Arg2:T78 |
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166 |
T80 Date 1681 1698 February 24, 2016 |
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167 |
E48 Date:T80 |
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168 |
R36 MODIFY Arg1:T78 Arg2:E46 |
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169 |
T81 Diagnostic_procedure 1730 1754 pathological examination |
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170 |
E49 Diagnostic_procedure:T81 |
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171 |
T82 Sign_symptom 1780 1791 hyperplasia |
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172 |
E50 Sign_symptom:T82 |
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173 |
T83 Detailed_description 1767 1779 inflammatory |
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174 |
R37 MODIFY Arg1:T83 Arg2:E50 |
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175 |
T84 Biological_structure 1792 1802 lymph node |
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176 |
R38 MODIFY Arg1:T84 Arg2:E50 |
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177 |
T85 Medication 1804 1812 Apatinib |
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178 |
E51 Medication:T85 |
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179 |
A6 POLARITY E51 NEG |
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180 |
T86 Duration 1851 1858 3 weeks |
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181 |
E52 Duration:T86 |
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182 |
T87 Therapeutic_procedure 1862 1875 wound healing |
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183 |
E53 Therapeutic_procedure:T87 |
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184 |
T88 Diagnostic_procedure 1899 1901 CT |
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185 |
E54 Diagnostic_procedure:T88 |
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186 |
T89 Biological_structure 1893 1898 chest |
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187 |
T90 Detailed_description 1888 1892 thin |
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188 |
R39 MODIFY Arg1:T89 Arg2:E54 |
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189 |
R40 MODIFY Arg1:T90 Arg2:E54 |
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190 |
T91 Date 1916 1931 7 and 11 months |
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191 |
E55 Date:T91 |
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192 |
T92 Clinical_event 1982 1991 follow-up |
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193 |
E56 Clinical_event:T92 |
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194 |
T93 Date 1974 1981 7-month |
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195 |
E57 Date:T93 |
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196 |
T94 Lab_value 2658 2660 PR |
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197 |
#2 AnnotatorNotes T94 partial response |
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198 |
T95 Diagnostic_procedure 2581 2592 measurement |
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199 |
E58 Diagnostic_procedure:T95 |
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200 |
T96 Detailed_description 2574 2580 lesion |
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201 |
R41 MODIFY Arg1:T96 Arg2:E58 |
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202 |
T97 Diagnostic_procedure 2610 2629 RECIST 1.1 standard |
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203 |
E59 Diagnostic_procedure:T97 |
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204 |
R42 SUB_PROCEDURE Arg1:E59 Arg2:E58 |
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205 |
R43 MODIFY Arg1:T94 Arg2:E59 |
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206 |
T98 Disease_disorder 2715 2733 hand-foot syndrome |
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207 |
E60 Disease_disorder:T98 |
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208 |
T99 Severity 2710 2714 mild |
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209 |
R44 MODIFY Arg1:T99 Arg2:E60 |
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210 |
T100 Sign_symptom 2745 2764 high blood pressure |
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211 |
E61 Sign_symptom:T100 |
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212 |
T101 Severity 2738 2744 slight |
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213 |
R45 MODIFY Arg1:T101 Arg2:E61 |
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214 |
T102 Lab_value 2776 2819 well controlled after appropriate treatment |
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215 |
R46 MODIFY Arg1:T102 Arg2:E60 |
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216 |
R47 MODIFY Arg1:T102 Arg2:E61 |
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217 |
T103 Sign_symptom 2831 2841 toxicities |
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218 |
E62 Sign_symptom:T103 |
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219 |
A7 POLARITY E62 NEG |
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220 |
T104 Sign_symptom 2870 2884 adverse events |
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221 |
E63 Sign_symptom:T104 |
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222 |
A8 POLARITY E63 NEG |
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223 |
T105 Severity 2824 2830 severe |
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224 |
R48 MODIFY Arg1:T105 Arg2:E62 |
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225 |
T106 Detailed_description 2852 2869 treatment-related |
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226 |
R49 MODIFY Arg1:T106 Arg2:E63 |
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227 |
T107 Medication 2929 2937 apatinib |
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228 |
E64 Medication:T107 |
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229 |
T108 Sign_symptom 2975 2988 toxic effects |
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230 |
E65 Sign_symptom:T108 |
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231 |
A9 POLARITY E65 NEG |
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232 |
T109 Clinical_event 2994 3018 went back to normal life |
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233 |
E66 Clinical_event:T109 |
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234 |
T111 Detailed_description 3036 3049 automatic car |
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235 |
#3 AnnotatorNotes T111 why is this relevant |
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236 |
R51 MODIFY Arg1:T111 Arg2:E41 |
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237 |
T112 Sign_symptom 2057 2064 lesions |
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238 |
E67 Sign_symptom:T112 |
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239 |
A10 POLARITY E67 NEG |
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240 |
T113 Lab_value 2004 2025 2 out of 5 measurable |
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241 |
T114 Lab_value 2030 2056 9 out of 17 non-measurable |
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242 |
R52 MODIFY Arg1:T114 Arg2:E67 |
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243 |
R53 MODIFY Arg1:T113 Arg2:E67 |
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244 |
T115 Sign_symptom 2099 2105 nodule |
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245 |
E68 Sign_symptom:T115 |
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246 |
T116 Sign_symptom 2131 2138 lesions |
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247 |
E69 Sign_symptom:T116 |
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248 |
T117 Lab_value 2082 2098 1 new measurable |
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249 |
R54 MODIFY Arg1:T117 Arg2:E68 |
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250 |
T118 Lab_value 2110 2130 6 new non-measurable |
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251 |
R55 MODIFY Arg1:T118 Arg2:E69 |
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252 |
T119 Diagnostic_procedure 2209 2253 Response Evaluation Criteria in Solid Tumors |
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253 |
E70 Diagnostic_procedure:T119 |
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254 |
T120 Diagnostic_procedure 2255 2261 RECIST |
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255 |
E71 Diagnostic_procedure:T120 |
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256 |
R56 IDENTICAL Arg1:E71 Arg2:E70 |
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257 |
T121 Detailed_description 2263 2266 1.1 |
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258 |
R57 MODIFY Arg1:T121 Arg2:E70 |
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259 |
T122 Lab_value 2189 2191 PD |
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260 |
R58 MODIFY Arg1:T122 Arg2:E70 |
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261 |
T123 Clinical_event 2302 2311 follow-up |
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262 |
E72 Clinical_event:T123 |
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263 |
T124 Date 2293 2301 11-month |
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264 |
E73 Date:T124 |
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265 |
T125 Sign_symptom 2337 2344 lesions |
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266 |
E74 Sign_symptom:T125 |
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267 |
A11 POLARITY E74 NEG |
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268 |
T126 Lab_value 2335 2336 9 |
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269 |
R59 MODIFY Arg1:T126 Arg2:E74 |
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270 |
T127 Lab_value 2368 2387 1 measurable nodule |
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271 |
R60 MODIFY Arg1:T127 Arg2:E74 |
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272 |
T128 Lab_value 2392 2416 2 non-measurable lesions |
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273 |
R61 MODIFY Arg1:T128 Arg2:E74 |
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274 |
T129 Lab_value 2464 2489 6 non-measureable lesions |
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275 |
R62 MODIFY Arg1:T129 Arg2:E74 |
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276 |
R63 MODIFY Arg1:T5 Arg2:E2 |
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277 |
* OVERLAP E1 E2 E3 |
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278 |
R64 BEFORE Arg1:E3 Arg2:E4 |
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279 |
* OVERLAP E4 E7 E6 E8 E9 E5 |
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280 |
R65 BEFORE Arg1:E5 Arg2:E10 |
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281 |
* OVERLAP E10 E11 E12 |
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282 |
R66 BEFORE Arg1:E12 Arg2:E16 |
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283 |
* OVERLAP E16 E17 |
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284 |
R67 BEFORE Arg1:E17 Arg2:E18 |
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285 |
* OVERLAP E18 E19 E20 |
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286 |
R68 BEFORE Arg1:E20 Arg2:E21 |
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287 |
* OVERLAP E21 E22 |
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288 |
R69 BEFORE Arg1:E22 Arg2:E23 |
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289 |
R70 BEFORE Arg1:E23 Arg2:E24 |
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290 |
* OVERLAP E24 E25 E26 |
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291 |
R71 BEFORE Arg1:E26 Arg2:E27 |
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292 |
* OVERLAP E27 E28 E29 |
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293 |
R72 BEFORE Arg1:E29 Arg2:E30 |
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294 |
* OVERLAP E30 E32 E33 E34 E35 E36 E37 E38 E39 |
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295 |
R73 BEFORE Arg1:E39 Arg2:E40 |
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296 |
R74 BEFORE Arg1:E40 Arg2:E42 |
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297 |
* OVERLAP E42 E43 E44 |
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298 |
R75 BEFORE Arg1:E44 Arg2:E45 |
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299 |
* OVERLAP E45 E47 E46 E48 E49 E50 |
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300 |
R76 BEFORE Arg1:E50 Arg2:E51 |
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301 |
* OVERLAP E51 E52 E53 |
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302 |
R77 BEFORE Arg1:E53 Arg2:E54 |
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303 |
* OVERLAP E54 E55 E57 E56 E67 E68 E69 E70 |
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304 |
R78 BEFORE Arg1:E70 Arg2:E73 |
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305 |
* OVERLAP E73 E72 E74 E58 E60 E61 E62 E63 |
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306 |
R79 BEFORE Arg1:E63 Arg2:E64 |
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307 |
* OVERLAP E64 E65 E66 E41 |