a b/processing/MACCROBAT/28383413.ann
1
T1  Date 2 12   March 2015
2
E1  Date:T1 
3
T2  Age 16 27   62-year-old
4
T3  Sex 28 33   woman
5
T4  Clinical_event 38 46    admitted
6
E2  Clinical_event:T4 
7
T5  Nonbiological_location 54 62    hospital
8
R1  MODIFY Arg1:T5 Arg2:E2  
9
T6  Sign_symptom 94 112 visual disturbance
10
E3  Sign_symptom:T6 
11
T7  Detailed_description 82 93  progressive
12
R2  MODIFY Arg1:T7 Arg2:E3  
13
T8  Date 132 143    4 years ago
14
E4  Date:T8 
15
T9  Disease_disorder 163 171    cataract
16
E5  Disease_disorder:T9 
17
A1  POLARITY E5 UNCERTAIN
18
T10 Nonbiological_location 175 189  local hospital
19
R3  MODIFY Arg1:T10 Arg2:E5 
20
T11 Sign_symptom 198 204    relief
21
E6  Sign_symptom:T11 
22
A2  POLARITY E6 NEG
23
T12 Date 256 271    half a year ago
24
E7  Date:T12 
25
T13 Sign_symptom 236 244    symptoms
26
E8  Sign_symptom:T13 
27
A3  TREND E8 INC
28
T14 Sign_symptom 287 295    headache
29
E9  Sign_symptom:T14 
30
T15 Sign_symptom 306 310    pain
31
E10 Sign_symptom:T15 
32
T16 Biological_structure 297 305    left eye
33
R4  MODIFY Arg1:T16 Arg2:E10    
34
T17 Sign_symptom 312 319    tearing
35
E11 Sign_symptom:T17 
36
T18 Sign_symptom 334 344    secretions
37
E12 Sign_symptom:T18 
38
A4  TREND E12 INC
39
T19 Diagnostic_procedure 354 373    computed tomography
40
E13 Diagnostic_procedure:T19 
41
T20 Diagnostic_procedure 375 377    CT
42
E14 Diagnostic_procedure:T20 
43
R5  IDENTICAL Arg1:E14 Arg2:E13 
44
T21 Biological_structure 391 396    brain
45
R6  MODIFY Arg1:T21 Arg2:E13    
46
T22 Nonbiological_location 400 414  local hospital
47
R7  MODIFY Arg1:T22 Arg2:E13    
48
T23 Sign_symptom 438 444    lesion
49
E15 Sign_symptom:T23 
50
T24 Biological_structure 424 437    sellar region
51
R8  MODIFY Arg1:T24 Arg2:E15    
52
T25 Date 455 470    2 years earlier
53
E16 Date:T25 
54
T26 Therapeutic_procedure 494 503   resection
55
E17 Therapeutic_procedure:T26 
56
T27 Disease_disorder 507 515    melanoma
57
E18 Disease_disorder:T27 
58
T28 Biological_structure 523 532    left heel
59
R9  MODIFY Arg1:T28 Arg2:E18    
60
T29 Lab_value 534 540   T2N0M0
61
R10 MODIFY Arg1:T29 Arg2:E18    
62
T30 Lab_value 542 551   ki67 3–5%
63
T31 Lab_value 553 561   Stage II
64
R11 MODIFY Arg1:T30 Arg2:E18    
65
R12 MODIFY Arg1:T31 Arg2:E18    
66
T32 Therapeutic_procedure 576 585   resection
67
E19 Therapeutic_procedure:T32 
68
T33 Disease_disorder 602 610    melanoma
69
E20 Disease_disorder:T33 
70
T34 Detailed_description 593 601    recurred
71
R13 MODIFY Arg1:T34 Arg2:E20    
72
T35 Biological_structure 611 634    nearby the primary site
73
R14 MODIFY Arg1:T35 Arg2:E20    
74
T36 Date 635 650    15 months later
75
E21 Date:T36 
76
T37 Lab_value 652 658   T3N3M0
77
R15 MODIFY Arg1:T37 Arg2:E20    
78
T38 Lab_value 660 669   Stage III
79
R16 MODIFY Arg1:T38 Arg2:E20    
80
T39 Therapeutic_procedure 680 695   lymphadenectomy
81
E22 Therapeutic_procedure:T39 
82
A5  POLARITY E22 NEG
83
T40 Family_history 705 734  no family history of melanoma
84
T41 Diagnostic_procedure 739 759    physical examination
85
E23 Diagnostic_procedure:T41 
86
T42 Sign_symptom 796 807    hemianopsia
87
E24 Sign_symptom:T42 
88
T43 Detailed_description 787 795    temporal
89
T44 Detailed_description 777 786    bilateral
90
R17 MODIFY Arg1:T43 Arg2:E24    
91
R18 MODIFY Arg1:T44 Arg2:E24    
92
T45 Diagnostic_procedure 813 834    right finger counting
93
E25 Diagnostic_procedure:T45 
94
T46 Lab_value 839 842   1 m
95
R19 MODIFY Arg1:T46 Arg2:E25    
96
T47 Diagnostic_procedure 852 872    left finger counting
97
E26 Diagnostic_procedure:T47 
98
T48 Lab_value 877 895   no more than 0.5 m
99
R20 MODIFY Arg1:T48 Arg2:E26    
100
T49 Sign_symptom 897 905    Enlarged
101
E27 Sign_symptom:T49 
102
T50 Biological_structure 906 917    lymph nodes
103
R21 MODIFY Arg1:T50 Arg2:E27    
104
T51 Biological_structure 939 950    right groin
105
R22 MODIFY Arg1:T51 Arg2:E27    
106
T52 Diagnostic_procedure 955 981    ophthalmologic examination
107
E28 Diagnostic_procedure:T52 
108
T53 Diagnostic_procedure 999 1011   right vision
109
E29 Diagnostic_procedure:T53 
110
T54 Lab_value 1015 1018 0.4
111
R23 MODIFY Arg1:T54 Arg2:E29    
112
R24 SUB_PROCEDURE Arg1:E29 Arg2:E28 
113
T55 Diagnostic_procedure 1023 1034  left vision
114
E30 Diagnostic_procedure:T55 
115
T56 Lab_value 1038 1042 0.08
116
R25 MODIFY Arg1:T56 Arg2:E30    
117
T57 Diagnostic_procedure 1058 1078  intraocular pressure
118
E31 Diagnostic_procedure:T57 
119
T58 Lab_value 1079 1087 15 mm Hg
120
R26 MODIFY Arg1:T58 Arg2:E31    
121
T59 Detailed_description 1088 1099  bilaterally
122
R27 MODIFY Arg1:T59 Arg2:T58    
123
R28 SUB_PROCEDURE Arg1:E31 Arg2:E28 
124
T60 Diagnostic_procedure 1105 1114  optometry
125
E32 Diagnostic_procedure:T60 
126
T61 Lab_value 1138 1157 +6.00DS/+0.25DC∗65°
127
T62 Lab_value 1178 1197 +6.25DS/+0.50DC∗20°
128
T63 Biological_structure 1166 1174  left eye
129
R29 MODIFY Arg1:T63 Arg2:T62    
130
T64 Biological_structure 1125 1134  right eye
131
R30 MODIFY Arg1:T64 Arg2:T61    
132
R31 MODIFY Arg1:T61 Arg2:E32    
133
R32 MODIFY Arg1:T62 Arg2:E32    
134
T65 Disease_disorder 1215 1226  maculopathy
135
E33 Disease_disorder:T65 
136
T66 Biological_structure 1230 1239  both eyes
137
R33 MODIFY Arg1:T66 Arg2:E33    
138
T67 Disease_disorder 1244 1257  optic atrophy
139
E34 Disease_disorder:T67 
140
T68 Biological_structure 1265 1273  left eye
141
R34 MODIFY Arg1:T68 Arg2:E34    
142
T69 Diagnostic_procedure 1275 1287  Light reflex
143
E35 Diagnostic_procedure:T69 
144
T70 Diagnostic_procedure 1292 1304  eye movement
145
E36 Diagnostic_procedure:T70 
146
T71 Biological_structure 1308 1317  both eyes
147
R35 MODIFY Arg1:T71 Arg2:E36    
148
R36 MODIFY Arg1:T71 Arg2:E35    
149
T72 Lab_value 1323 1329 normal
150
R37 MODIFY Arg1:T72 Arg2:E36    
151
R38 MODIFY Arg1:T72 Arg2:E35    
152
T73 Diagnostic_procedure 1331 1333  CT
153
E37 Diagnostic_procedure:T73 
154
T74 Biological_structure 1347 1363  brain parenchyma
155
R39 MODIFY Arg1:T74 Arg2:E37    
156
T75 Biological_structure 1365 1372  orbital
157
T76 Biological_structure 1378 1383  chest
158
R40 MODIFY Arg1:T75 Arg2:E37    
159
R41 MODIFY Arg1:T76 Arg2:E37    
160
T77 Lab_value 1389 1401 unremarkable
161
R42 MODIFY Arg1:T77 Arg2:E37    
162
T78 Diagnostic_procedure 1403 1405  CT
163
E38 Diagnostic_procedure:T78 
164
T79 Diagnostic_procedure 1415 1425  ultrasound
165
E39 Diagnostic_procedure:T79 
166
T80 Biological_structure 1445 1452  abdomen
167
R43 MODIFY Arg1:T80 Arg2:E39    
168
R44 MODIFY Arg1:T80 Arg2:E38    
169
T81 Date 5128 5146  late January, 2017
170
E40 Date:T81 
171
T82 Sign_symptom 5164 5169  alive
172
E41 Sign_symptom:T82 
173
T83 Sign_symptom 5181 5189  symptoms
174
E42 Sign_symptom:T83 
175
A6  TREND E42 INC
176
T84 Sign_symptom 5199 5215  sensory deficits
177
E43 Sign_symptom:T84 
178
T85 Biological_structure 5219 5228  both legs
179
R45 MODIFY Arg1:T85 Arg2:E43    
180
T86 Sign_symptom 5236 5250  could not move
181
E44 Sign_symptom:T86 
182
R46 MODIFY Arg1:T85 Arg2:E44    
183
T87 Sign_symptom 5252 5264  hyperalgesia
184
E45 Sign_symptom:T87 
185
T88 Biological_structure 5268 5273  hands
186
T89 Biological_structure 5278 5283  mouth
187
T90 Sign_symptom 5285 5306  impaired intelligence
188
E46 Sign_symptom:T90 
189
R47 MODIFY Arg1:T88 Arg2:E45    
190
R48 MODIFY Arg1:T89 Arg2:E45    
191
T91 Clinical_event 5355 5362    nursing
192
E47 Clinical_event:T91 
193
T92 Subject 5370 5378   daughter
194
R49 MODIFY Arg1:T92 Arg2:E47    
195
T93 Sign_symptom 1495 1511  lymphadenectasis
196
E48 Sign_symptom:T93 
197
T94 Biological_structure 1479 1494  retroperitoneal
198
T95 Biological_structure 1460 1474  hepatic portal
199
R50 MODIFY Arg1:T94 Arg2:E48    
200
R51 MODIFY Arg1:T95 Arg2:E48    
201
T96 Sign_symptom 1516 1524  enlarged
202
E49 Sign_symptom:T96 
203
T97 Biological_structure 1525 1547  left lobe of the liver
204
R52 MODIFY Arg1:T97 Arg2:E49    
205
T98 Sign_symptom 1577 1584  lesions
206
E50 Sign_symptom:T98 
207
T99 Detailed_description 1565 1576  placeholder
208
T100    Severity 1553 1564  substantial
209
R53 MODIFY Arg1:T99 Arg2:E50    
210
R54 MODIFY Arg1:T100 Arg2:E50   
211
T101    Diagnostic_procedure 1586 1596  Ultrasound
212
E51 Diagnostic_procedure:T101 
213
T102    Biological_structure 1622 1642  inguinal lymph nodes
214
T103    Detailed_description 1612 1621  bilateral
215
R55 MODIFY Arg1:T103 Arg2:T102  
216
R56 MODIFY Arg1:T102 Arg2:E51   
217
T104    Sign_symptom 1663 1684  low echo light groups
218
E52 Sign_symptom:T104 
219
T105    Detailed_description 1654 1662  multiple
220
R57 MODIFY Arg1:T105 Arg2:E52   
221
T106    Distance 1690 1716  largest of which was 31 mm
222
R58 MODIFY Arg1:T106 Arg2:E52   
223
T107    Detailed_description 1735 1752  hilus of the echo
224
R59 MODIFY Arg1:T107 Arg2:E52   
225
T108    Sign_symptom 1770 1780  thickening
226
E53 Sign_symptom:T108 
227
T109    Biological_structure 1788 1792  skin
228
R60 MODIFY Arg1:T109 Arg2:E53   
229
T110    Detailed_description 1757 1769  asymmetrical
230
R61 MODIFY Arg1:T110 Arg2:E53   
231
T111    Diagnostic_procedure 1794 1796  CT
232
E54 Diagnostic_procedure:T111 
233
T112    Biological_structure 1805 1818  sellar region
234
R62 MODIFY Arg1:T112 Arg2:E54   
235
T113    Sign_symptom 1837 1841  mass
236
E55 Sign_symptom:T113 
237
T114    Texture 1830 1836   crumby
238
R63 MODIFY Arg1:T114 Arg2:E55   
239
T115    Biological_structure 1865 1879  sphenoid sinus
240
R64 MODIFY Arg1:T115 Arg2:E55   
241
T116    Detailed_description 1886 1902  obscure boundary
242
T117    Detailed_description 1907 1923  bone destruction
243
R65 MODIFY Arg1:T116 Arg2:E55   
244
R66 MODIFY Arg1:T117 Arg2:E55   
245
T118    Diagnostic_procedure 1941 1949  CT value
246
E56 Diagnostic_procedure:T118 
247
T119    Sign_symptom 1957 1961  mass
248
E57 Sign_symptom:T119 
249
R67 MODIFY Arg1:E57 Arg2:E56    
250
T120    Lab_value 1966 1971 46 HU
251
R68 MODIFY Arg1:T120 Arg2:E56   
252
T121    Detailed_description 1933 1940  average
253
R69 MODIFY Arg1:T121 Arg2:E56   
254
T122    Diagnostic_procedure 2015 2018  MRI
255
E58 Diagnostic_procedure:T122 
256
T123    Diagnostic_procedure 1987 2013  magnetic resonance imaging
257
E59 Diagnostic_procedure:T123 
258
R70 IDENTICAL Arg1:E58 Arg2:E59 
259
T124    Biological_structure 1973 1986  Sellar region
260
R71 MODIFY Arg1:T124 Arg2:E59   
261
T125    Sign_symptom 2037 2041  mass
262
E60 Sign_symptom:T125 
263
T126    Shape 2031 2036 round
264
R72 MODIFY Arg1:T126 Arg2:E60   
265
T127    Distance 2045 2050  30 mm
266
R73 MODIFY Arg1:T127 Arg2:E60   
267
T128    Biological_structure 2070 2085  enlarged sellae
268
R74 MODIFY Arg1:T128 Arg2:E60   
269
T129    Coreference 2103 2107   mass
270
E61 Coreference:T129 
271
R75 IDENTICAL Arg1:E61 Arg2:E60 
272
T130    Sign_symptom 2115 2125  isointense
273
E62 Sign_symptom:T130 
274
T131    Diagnostic_procedure 2129 2147  T1-weighted images
275
E63 Diagnostic_procedure:T131 
276
T132    Diagnostic_procedure 2149 2154  T1-WI
277
E64 Diagnostic_procedure:T132 
278
T133    Diagnostic_procedure 2160 2178  T2-weighted images
279
E65 Diagnostic_procedure:T133 
280
T134    Diagnostic_procedure 2180 2185  T2-WI
281
E66 Diagnostic_procedure:T134 
282
R76 IDENTICAL Arg1:E64 Arg2:E63 
283
R77 IDENTICAL Arg1:E66 Arg2:E65 
284
T135    Sign_symptom 2205 2216  enhancement
285
E67 Sign_symptom:T135 
286
T136    Detailed_description 2193 2204  homogeneous
287
R78 MODIFY Arg1:T136 Arg2:E67   
288
T137    Detailed_description 2223 2248  Gadolinium-DTPA injection
289
R79 MODIFY Arg1:T137 Arg2:E67   
290
T138    Detailed_description 2254 2269  dural tail sign
291
R80 MODIFY Arg1:T138 Arg2:E67   
292
T139    Coreference 2302 2307   tumor
293
E68 Coreference:T139 
294
R81 IDENTICAL Arg1:E68 Arg2:E61 
295
T140    Sign_symptom 2315 2335  hyperintense signals
296
E69 Sign_symptom:T140 
297
T141    Diagnostic_procedure 2339 2344  T1-WI
298
E70 Diagnostic_procedure:T141 
299
T142    Diagnostic_procedure 2372 2377  T2-WI
300
E71 Diagnostic_procedure:T142 
301
T143    Detailed_description 2379 2398  without enhancement
302
R82 MODIFY Arg1:T143 Arg2:E71   
303
T144    Sign_symptom 2349 2368  hypointense signals
304
E72 Sign_symptom:T144 
305
T145    Coreference 2425 2429   mass
306
E73 Coreference:T145 
307
R83 IDENTICAL Arg1:E73 Arg2:E68 
308
T146    Biological_structure 2441 2449  meninges
309
R84 MODIFY Arg1:T146 Arg2:E73   
310
T147    Biological_structure 2466 2494  left internal carotid artery
311
T148    Biological_structure 2521 2537  left optic nerve
312
R85 MODIFY Arg1:T147 Arg2:E73   
313
R86 MODIFY Arg1:T148 Arg2:E73   
314
T149    Sign_symptom 2562 2569  shorter
315
E74 Sign_symptom:T149 
316
T150    Biological_structure 2539 2554  Pituitary stalk
317
R87 MODIFY Arg1:T150 Arg2:E74   
318
T151    Detailed_description 2577 2595  right displacement
319
R88 MODIFY Arg1:T151 Arg2:E74   
320
T152    Diagnostic_procedure 2597 2616  Laboratory findings
321
E75 Diagnostic_procedure:T152 
322
T153    Diagnostic_procedure 2646 2655  prolactin
323
E76 Diagnostic_procedure:T153 
324
T154    Lab_value 2657 2668 119.08 μg/L
325
R89 MODIFY Arg1:T154 Arg2:E76   
326
R90 SUB_PROCEDURE Arg1:E76 Arg2:E75 
327
T155    Diagnostic_procedure 2704 2712  cortisol
328
E77 Diagnostic_procedure:T155 
329
T156    Lab_value 2714 2727 677.10 nmol/L
330
R91 MODIFY Arg1:T156 Arg2:E77   
331
R92 SUB_PROCEDURE Arg1:E77 Arg2:E75 
332
T157    Lab_value 2768 2777 decreased
333
T158    Lab_value 2626 2635 increased
334
R93 MODIFY Arg1:T158 Arg2:E76   
335
R94 MODIFY Arg1:T158 Arg2:E77   
336
T159    Diagnostic_procedure 2788 2802  free thyroxine
337
E78 Diagnostic_procedure:T159 
338
T160    Diagnostic_procedure 2804 2807  FT4
339
E79 Diagnostic_procedure:T160 
340
R95 IDENTICAL Arg1:E79 Arg2:E78 
341
T161    Lab_value 2810 2821 6.04 pmol/L
342
R96 MODIFY Arg1:T161 Arg2:E78   
343
R97 MODIFY Arg1:T157 Arg2:E78   
344
T162    Diagnostic_procedure 2860 2881  free triiodothyronine
345
E80 Diagnostic_procedure:T162 
346
T163    Diagnostic_procedure 2883 2886  FT3
347
E81 Diagnostic_procedure:T163 
348
T164    Lab_value 2889 2900 2.09 pmol/L
349
R98 IDENTICAL Arg1:E81 Arg2:E80 
350
R99 MODIFY Arg1:T157 Arg2:E80   
351
R100    MODIFY Arg1:T164 Arg2:E80   
352
R101    SUB_PROCEDURE Arg1:E78 Arg2:E75 
353
R102    SUB_PROCEDURE Arg1:E80 Arg2:E75 
354
T165    Disease_disorder 2973 2985  prolactinoma
355
E82 Disease_disorder:T165 
356
T166    Detailed_description 2967 2972  giant
357
R103    MODIFY Arg1:T166 Arg2:E82   
358
T167    Therapeutic_procedure 3036 3043 surgery
359
E83 Therapeutic_procedure:T167 
360
T168    Detailed_description 3020 3035  transsphenoidal
361
T169    Detailed_description 3009 3019  transnasal
362
R104    MODIFY Arg1:T168 Arg2:E83   
363
R105    MODIFY Arg1:T169 Arg2:E83   
364
T170    Sign_symptom 3151 3156  tumor
365
E84 Sign_symptom:T170 
366
T171    Biological_structure 3180 3215  left interval of the sphenoid sinus
367
R106    MODIFY Arg1:T171 Arg2:E84   
368
T172    Biological_structure 3229 3249  bone in sellar floor
369
R107    MODIFY Arg1:T172 Arg2:E84   
370
T173    Biological_structure 3254 3274  left side parasellar
371
R108    MODIFY Arg1:T173 Arg2:E84   
372
T174    Sign_symptom 3279 3288  destroyed
373
E85 Sign_symptom:T174 
374
T175    Sign_symptom 3293 3301  absorbed
375
E86 Sign_symptom:T175 
376
R109    MODIFY Arg1:T173 Arg2:E85   
377
R110    MODIFY Arg1:T173 Arg2:E86   
378
T176    Biological_structure 3378 3392  sellar turcica
379
T177    Coreference 3365 3370   tumor
380
E87 Coreference:T177 
381
R111    IDENTICAL Arg1:E87 Arg2:E84 
382
T178    Detailed_description 3305 3361  little normal pituitary tissue was seen in the top right
383
R112    MODIFY Arg1:T178 Arg2:E87   
384
T179    Coreference 3398 3403   tumor
385
E88 Coreference:T179 
386
R113    IDENTICAL Arg1:E88 Arg2:E87 
387
T180    Color 3408 3421 reddish black
388
R114    MODIFY Arg1:T180 Arg2:E88   
389
T181    Detailed_description 3427 3454  extremely rich blood supply
390
R115    MODIFY Arg1:T181 Arg2:E88   
391
T182    Detailed_description 3463 3506  close adhesion to the surrounding structure
392
R116    MODIFY Arg1:T182 Arg2:E88   
393
T183    Coreference 3541 3546   tumor
394
E89 Coreference:T183 
395
R117    IDENTICAL Arg1:E89 Arg2:E88 
396
T184    Texture 3551 3555   soft
397
R118    MODIFY Arg1:T184 Arg2:E89   
398
T185    Texture 3560 3585   much tougher over the rim
399
R119    MODIFY Arg1:T185 Arg2:E89   
400
T186    Diagnostic_procedure 3602 3628  frozen-section examination
401
E90 Diagnostic_procedure:T186 
402
T187    Detailed_description 3587 3601  Intraoperative
403
R120    MODIFY Arg1:T187 Arg2:E90   
404
T188    Sign_symptom 3635 3651  melanin granules
405
E91 Sign_symptom:T188 
406
T189    Disease_disorder 3681 3699  malignant melanoma
407
E92 Disease_disorder:T189 
408
T190    Disease_disorder 3703 3713  meningioma
409
E93 Disease_disorder:T190 
410
T191    Activity 5056 5060  walk
411
E94 Activity:T191 
412
A7  POLARITY E94 NEG
413
T192    Disease_disorder 5089 5098  depressed
414
E95 Disease_disorder:T192 
415
T193    Clinical_event 5002 5011    follow-up
416
E96 Clinical_event:T193 
417
T194    Date 5015 5032  late January 2016
418
E97 Date:T194 
419
T195    Activity 5065 5080  live by herself
420
E98 Activity:T195 
421
A8  POLARITY E98 NEG
422
T196    Sign_symptom 4865 4881  metastatic sites
423
E99 Sign_symptom:T196 
424
T197    Disease_disorder 4856 4864  melanoma
425
E100    Disease_disorder:T197 
426
T198    Biological_structure 4889 4911  skin of lower left leg
427
T199    Biological_structure 4924 4938  upper left leg
428
T200    Biological_structure 4944 4954  left groin
429
T201    Biological_structure 4963 4974  right groin
430
T202    Biological_structure 4984 4993  right leg
431
R121    MODIFY Arg1:T198 Arg2:E99   
432
R122    MODIFY Arg1:T199 Arg2:E99   
433
R123    MODIFY Arg1:T200 Arg2:E99   
434
R124    MODIFY Arg1:T201 Arg2:E99   
435
R125    MODIFY Arg1:T202 Arg2:E99   
436
T203    Clinical_event 4719 4729    discharged
437
E101    Clinical_event:T203 
438
T204    Nonbiological_location 4739 4747    hospital
439
R126    MODIFY Arg1:T204 Arg2:E101  
440
T205    Date 4787 4801  2 months after
441
E102    Date:T205 
442
T206    Disease_disorder 4768 4775  disease
443
E103    Disease_disorder:T206 
444
A9  POLARITY E103 NEG
445
T207    Detailed_description 3748 3786  eosinophilic staining epithelial cells
446
T208    Coreference 3719 3730   tumor cells
447
E104    Coreference:T208 
448
R127    IDENTICAL Arg1:E104 Arg2:E89    
449
R128    MODIFY Arg1:T207 Arg2:E104  
450
T209    Diagnostic_procedure 3796 3807  cell nuclei
451
E105    Diagnostic_procedure:T209 
452
T210    Sign_symptom 3944 3952  necrosis
453
E106    Sign_symptom:T210 
454
A10 POLARITY E106 NEG
455
T211    Diagnostic_procedure 4003 4028  melanoma-specific markers
456
E107    Diagnostic_procedure:T211 
457
T212    Shape 3813 3818 round
458
R129    MODIFY Arg1:T212 Arg2:E105  
459
T213    Lab_value 3831 3839 reniform
460
T214    Lab_value 3844 3858 hippocrepiform
461
T215    Diagnostic_procedure 3886 3901  nuclear fission
462
E108    Diagnostic_procedure:T215 
463
R130    SUB_PROCEDURE Arg1:E105 Arg2:E90    
464
R131    MODIFY Arg1:T213 Arg2:E105  
465
R132    MODIFY Arg1:T214 Arg2:E105  
466
T216    Diagnostic_procedure 3872 3880  nucleoli
467
E109    Diagnostic_procedure:T216 
468
T217    Lab_value 3864 3871 evident
469
R133    MODIFY Arg1:T217 Arg2:E109  
470
R134    SUB_PROCEDURE Arg1:E109 Arg2:E105   
471
R135    SUB_PROCEDURE Arg1:E108 Arg2:E90    
472
T218    Lab_value 3906 3910 seen
473
R136    MODIFY Arg1:T218 Arg2:E108  
474
T219    Lab_value 3976 3990 immunopositive
475
R137    MODIFY Arg1:T219 Arg2:E107  
476
T220    Detailed_description 3991 3998  focally
477
R138    MODIFY Arg1:T220 Arg2:T219  
478
T221    Diagnostic_procedure 4037 4042  S-100
479
E110    Diagnostic_procedure:T221 
480
T222    Diagnostic_procedure 4044 4049  HMB45
481
E111    Diagnostic_procedure:T222 
482
T223    Diagnostic_procedure 4055 4063  Vimentin
483
E112    Diagnostic_procedure:T223 
484
R139    SUB_PROCEDURE Arg1:E110 Arg2:E107   
485
R140    SUB_PROCEDURE Arg1:E111 Arg2:E107   
486
R141    SUB_PROCEDURE Arg1:E112 Arg2:E107   
487
T224    Diagnostic_procedure 4088 4116  neuroendocrine tumor markers
488
E113    Diagnostic_procedure:T224 
489
T225    Lab_value 4069 4083 immunopositive
490
R142    MODIFY Arg1:T225 Arg2:E113  
491
T226    Diagnostic_procedure 4125 4128  CgA
492
E114    Diagnostic_procedure:T226 
493
T227    Diagnostic_procedure 4133 4136  Syn
494
E115    Diagnostic_procedure:T227 
495
R143    SUB_PROCEDURE Arg1:E114 Arg2:E113   
496
R144    SUB_PROCEDURE Arg1:E115 Arg2:E113   
497
T228    Diagnostic_procedure 4150 4160  Ki67 index
498
E116    Diagnostic_procedure:T228 
499
T229    Lab_value 4165 4173 3% to 5%
500
R145    MODIFY Arg1:T229 Arg2:E116  
501
T230    Lab_value 4182 4188 higher
502
T231    Detailed_description 4192 4245  metastatic melanoma than in the adenomatous component
503
R146    MODIFY Arg1:T231 Arg2:T230  
504
R147    MODIFY Arg1:T230 Arg2:E116  
505
T232    Disease_disorder 4375 4379  MMPA
506
E117    Disease_disorder:T232 
507
#1  AnnotatorNotes E117 Melanoma metastases to the pituitary adenoma
508
T235    Diagnostic_procedure 4427 4439  visual field
509
E119    Diagnostic_procedure:T235 
510
T233    Sign_symptom 4444 4452  headache
511
E118    Sign_symptom:T233 
512
A11 TREND E118 DEC
513
T234    Lab_value 4408 4414 relief
514
R148    MODIFY Arg1:T234 Arg2:E119  
515
T236    Diagnostic_procedure 4471 4480  prolactin
516
E120    Diagnostic_procedure:T236 
517
T237    Diagnostic_procedure 4482 4490  cortisol
518
E121    Diagnostic_procedure:T237 
519
T238    Diagnostic_procedure 4496 4499  FT4
520
E122    Diagnostic_procedure:T238 
521
T239    Lab_value 4512 4518 normal
522
R149    MODIFY Arg1:T239 Arg2:E120  
523
R150    MODIFY Arg1:T239 Arg2:E121  
524
R151    MODIFY Arg1:T239 Arg2:E122  
525
T240    Medication 4524 4551    hormone replacement therapy
526
E123    Medication:T240 
527
T241    Therapeutic_procedure 4669 4690 surgical intervention
528
E124    Therapeutic_procedure:T241 
529
A12 POLARITY E124 NEG
530
T242    Sign_symptom 4625 4635  discomfort
531
E125    Sign_symptom:T242 
532
A13 POLARITY E125 MAYBE_NEG
533
*   OVERLAP E1 E2
534
R152    AFTER Arg1:E2 Arg2:E3   
535
*   OVERLAP E3 E4 E5 E6
536
R153    BEFORE Arg1:E6 Arg2:E8  
537
*   OVERLAP E8 E7 E9 E10 E11 E12 E13 E15
538
R154    AFTER Arg1:E15 Arg2:E16 
539
*   OVERLAP E16 E17 E18
540
R155    BEFORE Arg1:E18 Arg2:E19    
541
*   OVERLAP E19 E20 E21 E22
542
R156    BEFORE Arg1:E22 Arg2:E23    
543
*   OVERLAP E23 E24 E25 E26 E27 E28 E32 E33 E34 E35 E36 E37 E38 E39 E48 E49 E50 E51 E52 E53 E54 E55 E56 E57 E59 E60 E61 E62 E63 E65 E67 E68 E69 E70 E72 E71 E73 E74 E75
544
R157    SUB_PROCEDURE Arg1:E30 Arg2:E28 
545
R158    MODIFY Arg1:E72 Arg2:E71    
546
R159    MODIFY Arg1:E69 Arg2:E70    
547
R160    MODIFY Arg1:E62 Arg2:E63    
548
R161    MODIFY Arg1:E62 Arg2:E65    
549
R162    BEFORE Arg1:E75 Arg2:E82    
550
R163    BEFORE Arg1:E82 Arg2:E83    
551
*   OVERLAP E83 E84 E85 E86 E87 E88 E89 E90 E91 E92 E93 E104 E126 E106 E107 E113 E116 E117
552
T243    Coreference 3916 3921   tumor
553
E126    Coreference:T243 
554
R164    IDENTICAL Arg1:E126 Arg2:E104   
555
R165    MODIFY Arg1:E126 Arg2:E106  
556
R166    BEFORE Arg1:E117 Arg2:E119  
557
*   OVERLAP E119 E118
558
R167    BEFORE Arg1:E118 Arg2:E120  
559
*   OVERLAP E120 E121 E122 E123
560
R168    BEFORE Arg1:E123 Arg2:E125  
561
*   OVERLAP E125 E124
562
R169    BEFORE Arg1:E124 Arg2:E101  
563
R170    BEFORE Arg1:E101 Arg2:E103  
564
R171    BEFORE Arg1:E103 Arg2:E102  
565
*   OVERLAP E102 E100 E99
566
R172    BEFORE Arg1:E99 Arg2:E96    
567
*   OVERLAP E96 E97 E94 E98 E95
568
T244    Clinical_event 5114 5123    follow-up
569
E127    Clinical_event:T244 
570
R173    BEFORE Arg1:E95 Arg2:E127   
571
*   OVERLAP E127 E40 E41 E42 E43 E44 E45 E46 E47