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T1 Date 2 12 March 2015 E1 Date:T1 T2 Age 16 27 62-year-old T3 Sex 28 33 woman T4 Clinical_event 38 46 admitted E2 Clinical_event:T4 T5 Nonbiological_location 54 62 hospital R1 MODIFY Arg1:T5 Arg2:E2 T6 Sign_symptom 94 112 visual disturbance E3 Sign_symptom:T6 T7 Detailed_description 82 93 progressive R2 MODIFY Arg1:T7 Arg2:E3 T8 Date 132 143 4 years ago E4 Date:T8 T9 Disease_disorder 163 171 cataract E5 Disease_disorder:T9 A1 POLARITY E5 UNCERTAIN T10 Nonbiological_location 175 189 local hospital R3 MODIFY Arg1:T10 Arg2:E5 T11 Sign_symptom 198 204 relief E6 Sign_symptom:T11 A2 POLARITY E6 NEG T12 Date 256 271 half a year ago E7 Date:T12 T13 Sign_symptom 236 244 symptoms E8 Sign_symptom:T13 A3 TREND E8 INC T14 Sign_symptom 287 295 headache E9 Sign_symptom:T14 T15 Sign_symptom 306 310 pain E10 Sign_symptom:T15 T16 Biological_structure 297 305 left eye R4 MODIFY Arg1:T16 Arg2:E10 T17 Sign_symptom 312 319 tearing E11 Sign_symptom:T17 T18 Sign_symptom 334 344 secretions E12 Sign_symptom:T18 A4 TREND E12 INC T19 Diagnostic_procedure 354 373 computed tomography E13 Diagnostic_procedure:T19 T20 Diagnostic_procedure 375 377 CT E14 Diagnostic_procedure:T20 R5 IDENTICAL Arg1:E14 Arg2:E13 T21 Biological_structure 391 396 brain R6 MODIFY Arg1:T21 Arg2:E13 T22 Nonbiological_location 400 414 local hospital R7 MODIFY Arg1:T22 Arg2:E13 T23 Sign_symptom 438 444 lesion E15 Sign_symptom:T23 T24 Biological_structure 424 437 sellar region R8 MODIFY Arg1:T24 Arg2:E15 T25 Date 455 470 2 years earlier E16 Date:T25 T26 Therapeutic_procedure 494 503 resection E17 Therapeutic_procedure:T26 T27 Disease_disorder 507 515 melanoma E18 Disease_disorder:T27 T28 Biological_structure 523 532 left heel R9 MODIFY Arg1:T28 Arg2:E18 T29 Lab_value 534 540 T2N0M0 R10 MODIFY Arg1:T29 Arg2:E18 T30 Lab_value 542 551 ki67 3–5% T31 Lab_value 553 561 Stage II R11 MODIFY Arg1:T30 Arg2:E18 R12 MODIFY Arg1:T31 Arg2:E18 T32 Therapeutic_procedure 576 585 resection E19 Therapeutic_procedure:T32 T33 Disease_disorder 602 610 melanoma E20 Disease_disorder:T33 T34 Detailed_description 593 601 recurred R13 MODIFY Arg1:T34 Arg2:E20 T35 Biological_structure 611 634 nearby the primary site R14 MODIFY Arg1:T35 Arg2:E20 T36 Date 635 650 15 months later E21 Date:T36 T37 Lab_value 652 658 T3N3M0 R15 MODIFY Arg1:T37 Arg2:E20 T38 Lab_value 660 669 Stage III R16 MODIFY Arg1:T38 Arg2:E20 T39 Therapeutic_procedure 680 695 lymphadenectomy E22 Therapeutic_procedure:T39 A5 POLARITY E22 NEG T40 Family_history 705 734 no family history of melanoma T41 Diagnostic_procedure 739 759 physical examination E23 Diagnostic_procedure:T41 T42 Sign_symptom 796 807 hemianopsia E24 Sign_symptom:T42 T43 Detailed_description 787 795 temporal T44 Detailed_description 777 786 bilateral R17 MODIFY Arg1:T43 Arg2:E24 R18 MODIFY Arg1:T44 Arg2:E24 T45 Diagnostic_procedure 813 834 right finger counting E25 Diagnostic_procedure:T45 T46 Lab_value 839 842 1 m R19 MODIFY Arg1:T46 Arg2:E25 T47 Diagnostic_procedure 852 872 left finger counting E26 Diagnostic_procedure:T47 T48 Lab_value 877 895 no more than 0.5 m R20 MODIFY Arg1:T48 Arg2:E26 T49 Sign_symptom 897 905 Enlarged E27 Sign_symptom:T49 T50 Biological_structure 906 917 lymph nodes R21 MODIFY Arg1:T50 Arg2:E27 T51 Biological_structure 939 950 right groin R22 MODIFY Arg1:T51 Arg2:E27 T52 Diagnostic_procedure 955 981 ophthalmologic examination E28 Diagnostic_procedure:T52 T53 Diagnostic_procedure 999 1011 right vision E29 Diagnostic_procedure:T53 T54 Lab_value 1015 1018 0.4 R23 MODIFY Arg1:T54 Arg2:E29 R24 SUB_PROCEDURE Arg1:E29 Arg2:E28 T55 Diagnostic_procedure 1023 1034 left vision E30 Diagnostic_procedure:T55 T56 Lab_value 1038 1042 0.08 R25 MODIFY Arg1:T56 Arg2:E30 T57 Diagnostic_procedure 1058 1078 intraocular pressure E31 Diagnostic_procedure:T57 T58 Lab_value 1079 1087 15 mm Hg R26 MODIFY Arg1:T58 Arg2:E31 T59 Detailed_description 1088 1099 bilaterally R27 MODIFY Arg1:T59 Arg2:T58 R28 SUB_PROCEDURE Arg1:E31 Arg2:E28 T60 Diagnostic_procedure 1105 1114 optometry E32 Diagnostic_procedure:T60 T61 Lab_value 1138 1157 +6.00DS/+0.25DC∗65° T62 Lab_value 1178 1197 +6.25DS/+0.50DC∗20° T63 Biological_structure 1166 1174 left eye R29 MODIFY Arg1:T63 Arg2:T62 T64 Biological_structure 1125 1134 right eye R30 MODIFY Arg1:T64 Arg2:T61 R31 MODIFY Arg1:T61 Arg2:E32 R32 MODIFY Arg1:T62 Arg2:E32 T65 Disease_disorder 1215 1226 maculopathy E33 Disease_disorder:T65 T66 Biological_structure 1230 1239 both eyes R33 MODIFY Arg1:T66 Arg2:E33 T67 Disease_disorder 1244 1257 optic atrophy E34 Disease_disorder:T67 T68 Biological_structure 1265 1273 left eye R34 MODIFY Arg1:T68 Arg2:E34 T69 Diagnostic_procedure 1275 1287 Light reflex E35 Diagnostic_procedure:T69 T70 Diagnostic_procedure 1292 1304 eye movement E36 Diagnostic_procedure:T70 T71 Biological_structure 1308 1317 both eyes R35 MODIFY Arg1:T71 Arg2:E36 R36 MODIFY Arg1:T71 Arg2:E35 T72 Lab_value 1323 1329 normal R37 MODIFY Arg1:T72 Arg2:E36 R38 MODIFY Arg1:T72 Arg2:E35 T73 Diagnostic_procedure 1331 1333 CT E37 Diagnostic_procedure:T73 T74 Biological_structure 1347 1363 brain parenchyma R39 MODIFY Arg1:T74 Arg2:E37 T75 Biological_structure 1365 1372 orbital T76 Biological_structure 1378 1383 chest R40 MODIFY Arg1:T75 Arg2:E37 R41 MODIFY Arg1:T76 Arg2:E37 T77 Lab_value 1389 1401 unremarkable R42 MODIFY Arg1:T77 Arg2:E37 T78 Diagnostic_procedure 1403 1405 CT E38 Diagnostic_procedure:T78 T79 Diagnostic_procedure 1415 1425 ultrasound E39 Diagnostic_procedure:T79 T80 Biological_structure 1445 1452 abdomen R43 MODIFY Arg1:T80 Arg2:E39 R44 MODIFY Arg1:T80 Arg2:E38 T81 Date 5128 5146 late January, 2017 E40 Date:T81 T82 Sign_symptom 5164 5169 alive E41 Sign_symptom:T82 T83 Sign_symptom 5181 5189 symptoms E42 Sign_symptom:T83 A6 TREND E42 INC T84 Sign_symptom 5199 5215 sensory deficits E43 Sign_symptom:T84 T85 Biological_structure 5219 5228 both legs R45 MODIFY Arg1:T85 Arg2:E43 T86 Sign_symptom 5236 5250 could not move E44 Sign_symptom:T86 R46 MODIFY Arg1:T85 Arg2:E44 T87 Sign_symptom 5252 5264 hyperalgesia E45 Sign_symptom:T87 T88 Biological_structure 5268 5273 hands T89 Biological_structure 5278 5283 mouth T90 Sign_symptom 5285 5306 impaired intelligence E46 Sign_symptom:T90 R47 MODIFY Arg1:T88 Arg2:E45 R48 MODIFY Arg1:T89 Arg2:E45 T91 Clinical_event 5355 5362 nursing E47 Clinical_event:T91 T92 Subject 5370 5378 daughter R49 MODIFY Arg1:T92 Arg2:E47 T93 Sign_symptom 1495 1511 lymphadenectasis E48 Sign_symptom:T93 T94 Biological_structure 1479 1494 retroperitoneal T95 Biological_structure 1460 1474 hepatic portal R50 MODIFY Arg1:T94 Arg2:E48 R51 MODIFY Arg1:T95 Arg2:E48 T96 Sign_symptom 1516 1524 enlarged E49 Sign_symptom:T96 T97 Biological_structure 1525 1547 left lobe of the liver R52 MODIFY Arg1:T97 Arg2:E49 T98 Sign_symptom 1577 1584 lesions E50 Sign_symptom:T98 T99 Detailed_description 1565 1576 placeholder T100 Severity 1553 1564 substantial R53 MODIFY Arg1:T99 Arg2:E50 R54 MODIFY Arg1:T100 Arg2:E50 T101 Diagnostic_procedure 1586 1596 Ultrasound E51 Diagnostic_procedure:T101 T102 Biological_structure 1622 1642 inguinal lymph nodes T103 Detailed_description 1612 1621 bilateral R55 MODIFY Arg1:T103 Arg2:T102 R56 MODIFY Arg1:T102 Arg2:E51 T104 Sign_symptom 1663 1684 low echo light groups E52 Sign_symptom:T104 T105 Detailed_description 1654 1662 multiple R57 MODIFY Arg1:T105 Arg2:E52 T106 Distance 1690 1716 largest of which was 31 mm R58 MODIFY Arg1:T106 Arg2:E52 T107 Detailed_description 1735 1752 hilus of the echo R59 MODIFY Arg1:T107 Arg2:E52 T108 Sign_symptom 1770 1780 thickening E53 Sign_symptom:T108 T109 Biological_structure 1788 1792 skin R60 MODIFY Arg1:T109 Arg2:E53 T110 Detailed_description 1757 1769 asymmetrical R61 MODIFY Arg1:T110 Arg2:E53 T111 Diagnostic_procedure 1794 1796 CT E54 Diagnostic_procedure:T111 T112 Biological_structure 1805 1818 sellar region R62 MODIFY Arg1:T112 Arg2:E54 T113 Sign_symptom 1837 1841 mass E55 Sign_symptom:T113 T114 Texture 1830 1836 crumby R63 MODIFY Arg1:T114 Arg2:E55 T115 Biological_structure 1865 1879 sphenoid sinus R64 MODIFY Arg1:T115 Arg2:E55 T116 Detailed_description 1886 1902 obscure boundary T117 Detailed_description 1907 1923 bone destruction R65 MODIFY Arg1:T116 Arg2:E55 R66 MODIFY Arg1:T117 Arg2:E55 T118 Diagnostic_procedure 1941 1949 CT value E56 Diagnostic_procedure:T118 T119 Sign_symptom 1957 1961 mass E57 Sign_symptom:T119 R67 MODIFY Arg1:E57 Arg2:E56 T120 Lab_value 1966 1971 46 HU R68 MODIFY Arg1:T120 Arg2:E56 T121 Detailed_description 1933 1940 average R69 MODIFY Arg1:T121 Arg2:E56 T122 Diagnostic_procedure 2015 2018 MRI E58 Diagnostic_procedure:T122 T123 Diagnostic_procedure 1987 2013 magnetic resonance imaging E59 Diagnostic_procedure:T123 R70 IDENTICAL Arg1:E58 Arg2:E59 T124 Biological_structure 1973 1986 Sellar region R71 MODIFY Arg1:T124 Arg2:E59 T125 Sign_symptom 2037 2041 mass E60 Sign_symptom:T125 T126 Shape 2031 2036 round R72 MODIFY Arg1:T126 Arg2:E60 T127 Distance 2045 2050 30 mm R73 MODIFY Arg1:T127 Arg2:E60 T128 Biological_structure 2070 2085 enlarged sellae R74 MODIFY Arg1:T128 Arg2:E60 T129 Coreference 2103 2107 mass E61 Coreference:T129 R75 IDENTICAL Arg1:E61 Arg2:E60 T130 Sign_symptom 2115 2125 isointense E62 Sign_symptom:T130 T131 Diagnostic_procedure 2129 2147 T1-weighted images E63 Diagnostic_procedure:T131 T132 Diagnostic_procedure 2149 2154 T1-WI E64 Diagnostic_procedure:T132 T133 Diagnostic_procedure 2160 2178 T2-weighted images E65 Diagnostic_procedure:T133 T134 Diagnostic_procedure 2180 2185 T2-WI E66 Diagnostic_procedure:T134 R76 IDENTICAL Arg1:E64 Arg2:E63 R77 IDENTICAL Arg1:E66 Arg2:E65 T135 Sign_symptom 2205 2216 enhancement E67 Sign_symptom:T135 T136 Detailed_description 2193 2204 homogeneous R78 MODIFY Arg1:T136 Arg2:E67 T137 Detailed_description 2223 2248 Gadolinium-DTPA injection R79 MODIFY Arg1:T137 Arg2:E67 T138 Detailed_description 2254 2269 dural tail sign R80 MODIFY Arg1:T138 Arg2:E67 T139 Coreference 2302 2307 tumor E68 Coreference:T139 R81 IDENTICAL Arg1:E68 Arg2:E61 T140 Sign_symptom 2315 2335 hyperintense signals E69 Sign_symptom:T140 T141 Diagnostic_procedure 2339 2344 T1-WI E70 Diagnostic_procedure:T141 T142 Diagnostic_procedure 2372 2377 T2-WI E71 Diagnostic_procedure:T142 T143 Detailed_description 2379 2398 without enhancement R82 MODIFY Arg1:T143 Arg2:E71 T144 Sign_symptom 2349 2368 hypointense signals E72 Sign_symptom:T144 T145 Coreference 2425 2429 mass E73 Coreference:T145 R83 IDENTICAL Arg1:E73 Arg2:E68 T146 Biological_structure 2441 2449 meninges R84 MODIFY Arg1:T146 Arg2:E73 T147 Biological_structure 2466 2494 left internal carotid artery T148 Biological_structure 2521 2537 left optic nerve R85 MODIFY Arg1:T147 Arg2:E73 R86 MODIFY Arg1:T148 Arg2:E73 T149 Sign_symptom 2562 2569 shorter E74 Sign_symptom:T149 T150 Biological_structure 2539 2554 Pituitary stalk R87 MODIFY Arg1:T150 Arg2:E74 T151 Detailed_description 2577 2595 right displacement R88 MODIFY Arg1:T151 Arg2:E74 T152 Diagnostic_procedure 2597 2616 Laboratory findings E75 Diagnostic_procedure:T152 T153 Diagnostic_procedure 2646 2655 prolactin E76 Diagnostic_procedure:T153 T154 Lab_value 2657 2668 119.08 μg/L R89 MODIFY Arg1:T154 Arg2:E76 R90 SUB_PROCEDURE Arg1:E76 Arg2:E75 T155 Diagnostic_procedure 2704 2712 cortisol E77 Diagnostic_procedure:T155 T156 Lab_value 2714 2727 677.10 nmol/L R91 MODIFY Arg1:T156 Arg2:E77 R92 SUB_PROCEDURE Arg1:E77 Arg2:E75 T157 Lab_value 2768 2777 decreased T158 Lab_value 2626 2635 increased R93 MODIFY Arg1:T158 Arg2:E76 R94 MODIFY Arg1:T158 Arg2:E77 T159 Diagnostic_procedure 2788 2802 free thyroxine E78 Diagnostic_procedure:T159 T160 Diagnostic_procedure 2804 2807 FT4 E79 Diagnostic_procedure:T160 R95 IDENTICAL Arg1:E79 Arg2:E78 T161 Lab_value 2810 2821 6.04 pmol/L R96 MODIFY Arg1:T161 Arg2:E78 R97 MODIFY Arg1:T157 Arg2:E78 T162 Diagnostic_procedure 2860 2881 free triiodothyronine E80 Diagnostic_procedure:T162 T163 Diagnostic_procedure 2883 2886 FT3 E81 Diagnostic_procedure:T163 T164 Lab_value 2889 2900 2.09 pmol/L R98 IDENTICAL Arg1:E81 Arg2:E80 R99 MODIFY Arg1:T157 Arg2:E80 R100 MODIFY Arg1:T164 Arg2:E80 R101 SUB_PROCEDURE Arg1:E78 Arg2:E75 R102 SUB_PROCEDURE Arg1:E80 Arg2:E75 T165 Disease_disorder 2973 2985 prolactinoma E82 Disease_disorder:T165 T166 Detailed_description 2967 2972 giant R103 MODIFY Arg1:T166 Arg2:E82 T167 Therapeutic_procedure 3036 3043 surgery E83 Therapeutic_procedure:T167 T168 Detailed_description 3020 3035 transsphenoidal T169 Detailed_description 3009 3019 transnasal R104 MODIFY Arg1:T168 Arg2:E83 R105 MODIFY Arg1:T169 Arg2:E83 T170 Sign_symptom 3151 3156 tumor E84 Sign_symptom:T170 T171 Biological_structure 3180 3215 left interval of the sphenoid sinus R106 MODIFY Arg1:T171 Arg2:E84 T172 Biological_structure 3229 3249 bone in sellar floor R107 MODIFY Arg1:T172 Arg2:E84 T173 Biological_structure 3254 3274 left side parasellar R108 MODIFY Arg1:T173 Arg2:E84 T174 Sign_symptom 3279 3288 destroyed E85 Sign_symptom:T174 T175 Sign_symptom 3293 3301 absorbed E86 Sign_symptom:T175 R109 MODIFY Arg1:T173 Arg2:E85 R110 MODIFY Arg1:T173 Arg2:E86 T176 Biological_structure 3378 3392 sellar turcica T177 Coreference 3365 3370 tumor E87 Coreference:T177 R111 IDENTICAL Arg1:E87 Arg2:E84 T178 Detailed_description 3305 3361 little normal pituitary tissue was seen in the top right R112 MODIFY Arg1:T178 Arg2:E87 T179 Coreference 3398 3403 tumor E88 Coreference:T179 R113 IDENTICAL Arg1:E88 Arg2:E87 T180 Color 3408 3421 reddish black R114 MODIFY Arg1:T180 Arg2:E88 T181 Detailed_description 3427 3454 extremely rich blood supply R115 MODIFY Arg1:T181 Arg2:E88 T182 Detailed_description 3463 3506 close adhesion to the surrounding structure R116 MODIFY Arg1:T182 Arg2:E88 T183 Coreference 3541 3546 tumor E89 Coreference:T183 R117 IDENTICAL Arg1:E89 Arg2:E88 T184 Texture 3551 3555 soft R118 MODIFY Arg1:T184 Arg2:E89 T185 Texture 3560 3585 much tougher over the rim R119 MODIFY Arg1:T185 Arg2:E89 T186 Diagnostic_procedure 3602 3628 frozen-section examination E90 Diagnostic_procedure:T186 T187 Detailed_description 3587 3601 Intraoperative R120 MODIFY Arg1:T187 Arg2:E90 T188 Sign_symptom 3635 3651 melanin granules E91 Sign_symptom:T188 T189 Disease_disorder 3681 3699 malignant melanoma E92 Disease_disorder:T189 T190 Disease_disorder 3703 3713 meningioma E93 Disease_disorder:T190 T191 Activity 5056 5060 walk E94 Activity:T191 A7 POLARITY E94 NEG T192 Disease_disorder 5089 5098 depressed E95 Disease_disorder:T192 T193 Clinical_event 5002 5011 follow-up E96 Clinical_event:T193 T194 Date 5015 5032 late January 2016 E97 Date:T194 T195 Activity 5065 5080 live by herself E98 Activity:T195 A8 POLARITY E98 NEG T196 Sign_symptom 4865 4881 metastatic sites E99 Sign_symptom:T196 T197 Disease_disorder 4856 4864 melanoma E100 Disease_disorder:T197 T198 Biological_structure 4889 4911 skin of lower left leg T199 Biological_structure 4924 4938 upper left leg T200 Biological_structure 4944 4954 left groin T201 Biological_structure 4963 4974 right groin T202 Biological_structure 4984 4993 right leg R121 MODIFY Arg1:T198 Arg2:E99 R122 MODIFY Arg1:T199 Arg2:E99 R123 MODIFY Arg1:T200 Arg2:E99 R124 MODIFY Arg1:T201 Arg2:E99 R125 MODIFY Arg1:T202 Arg2:E99 T203 Clinical_event 4719 4729 discharged E101 Clinical_event:T203 T204 Nonbiological_location 4739 4747 hospital R126 MODIFY Arg1:T204 Arg2:E101 T205 Date 4787 4801 2 months after E102 Date:T205 T206 Disease_disorder 4768 4775 disease E103 Disease_disorder:T206 A9 POLARITY E103 NEG T207 Detailed_description 3748 3786 eosinophilic staining epithelial cells T208 Coreference 3719 3730 tumor cells E104 Coreference:T208 R127 IDENTICAL Arg1:E104 Arg2:E89 R128 MODIFY Arg1:T207 Arg2:E104 T209 Diagnostic_procedure 3796 3807 cell nuclei E105 Diagnostic_procedure:T209 T210 Sign_symptom 3944 3952 necrosis E106 Sign_symptom:T210 A10 POLARITY E106 NEG T211 Diagnostic_procedure 4003 4028 melanoma-specific markers E107 Diagnostic_procedure:T211 T212 Shape 3813 3818 round R129 MODIFY Arg1:T212 Arg2:E105 T213 Lab_value 3831 3839 reniform T214 Lab_value 3844 3858 hippocrepiform T215 Diagnostic_procedure 3886 3901 nuclear fission E108 Diagnostic_procedure:T215 R130 SUB_PROCEDURE Arg1:E105 Arg2:E90 R131 MODIFY Arg1:T213 Arg2:E105 R132 MODIFY Arg1:T214 Arg2:E105 T216 Diagnostic_procedure 3872 3880 nucleoli E109 Diagnostic_procedure:T216 T217 Lab_value 3864 3871 evident R133 MODIFY Arg1:T217 Arg2:E109 R134 SUB_PROCEDURE Arg1:E109 Arg2:E105 R135 SUB_PROCEDURE Arg1:E108 Arg2:E90 T218 Lab_value 3906 3910 seen R136 MODIFY Arg1:T218 Arg2:E108 T219 Lab_value 3976 3990 immunopositive R137 MODIFY Arg1:T219 Arg2:E107 T220 Detailed_description 3991 3998 focally R138 MODIFY Arg1:T220 Arg2:T219 T221 Diagnostic_procedure 4037 4042 S-100 E110 Diagnostic_procedure:T221 T222 Diagnostic_procedure 4044 4049 HMB45 E111 Diagnostic_procedure:T222 T223 Diagnostic_procedure 4055 4063 Vimentin E112 Diagnostic_procedure:T223 R139 SUB_PROCEDURE Arg1:E110 Arg2:E107 R140 SUB_PROCEDURE Arg1:E111 Arg2:E107 R141 SUB_PROCEDURE Arg1:E112 Arg2:E107 T224 Diagnostic_procedure 4088 4116 neuroendocrine tumor markers E113 Diagnostic_procedure:T224 T225 Lab_value 4069 4083 immunopositive R142 MODIFY Arg1:T225 Arg2:E113 T226 Diagnostic_procedure 4125 4128 CgA E114 Diagnostic_procedure:T226 T227 Diagnostic_procedure 4133 4136 Syn E115 Diagnostic_procedure:T227 R143 SUB_PROCEDURE Arg1:E114 Arg2:E113 R144 SUB_PROCEDURE Arg1:E115 Arg2:E113 T228 Diagnostic_procedure 4150 4160 Ki67 index E116 Diagnostic_procedure:T228 T229 Lab_value 4165 4173 3% to 5% R145 MODIFY Arg1:T229 Arg2:E116 T230 Lab_value 4182 4188 higher T231 Detailed_description 4192 4245 metastatic melanoma than in the adenomatous component R146 MODIFY Arg1:T231 Arg2:T230 R147 MODIFY Arg1:T230 Arg2:E116 T232 Disease_disorder 4375 4379 MMPA E117 Disease_disorder:T232 #1 AnnotatorNotes E117 Melanoma metastases to the pituitary adenoma T235 Diagnostic_procedure 4427 4439 visual field E119 Diagnostic_procedure:T235 T233 Sign_symptom 4444 4452 headache E118 Sign_symptom:T233 A11 TREND E118 DEC T234 Lab_value 4408 4414 relief R148 MODIFY Arg1:T234 Arg2:E119 T236 Diagnostic_procedure 4471 4480 prolactin E120 Diagnostic_procedure:T236 T237 Diagnostic_procedure 4482 4490 cortisol E121 Diagnostic_procedure:T237 T238 Diagnostic_procedure 4496 4499 FT4 E122 Diagnostic_procedure:T238 T239 Lab_value 4512 4518 normal R149 MODIFY Arg1:T239 Arg2:E120 R150 MODIFY Arg1:T239 Arg2:E121 R151 MODIFY Arg1:T239 Arg2:E122 T240 Medication 4524 4551 hormone replacement therapy E123 Medication:T240 T241 Therapeutic_procedure 4669 4690 surgical intervention E124 Therapeutic_procedure:T241 A12 POLARITY E124 NEG T242 Sign_symptom 4625 4635 discomfort E125 Sign_symptom:T242 A13 POLARITY E125 MAYBE_NEG * OVERLAP E1 E2 R152 AFTER Arg1:E2 Arg2:E3 * OVERLAP E3 E4 E5 E6 R153 BEFORE Arg1:E6 Arg2:E8 * OVERLAP E8 E7 E9 E10 E11 E12 E13 E15 R154 AFTER Arg1:E15 Arg2:E16 * OVERLAP E16 E17 E18 R155 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 E21 E22 R156 BEFORE Arg1:E22 Arg2:E23 * OVERLAP E23 E24 E25 E26 E27 E28 E32 E33 E34 E35 E36 E37 E38 E39 E48 E49 E50 E51 E52 E53 E54 E55 E56 E57 E59 E60 E61 E62 E63 E65 E67 E68 E69 E70 E72 E71 E73 E74 E75 R157 SUB_PROCEDURE Arg1:E30 Arg2:E28 R158 MODIFY Arg1:E72 Arg2:E71 R159 MODIFY Arg1:E69 Arg2:E70 R160 MODIFY Arg1:E62 Arg2:E63 R161 MODIFY Arg1:E62 Arg2:E65 R162 BEFORE Arg1:E75 Arg2:E82 R163 BEFORE Arg1:E82 Arg2:E83 * OVERLAP E83 E84 E85 E86 E87 E88 E89 E90 E91 E92 E93 E104 E126 E106 E107 E113 E116 E117 T243 Coreference 3916 3921 tumor E126 Coreference:T243 R164 IDENTICAL Arg1:E126 Arg2:E104 R165 MODIFY Arg1:E126 Arg2:E106 R166 BEFORE Arg1:E117 Arg2:E119 * OVERLAP E119 E118 R167 BEFORE Arg1:E118 Arg2:E120 * OVERLAP E120 E121 E122 E123 R168 BEFORE Arg1:E123 Arg2:E125 * OVERLAP E125 E124 R169 BEFORE Arg1:E124 Arg2:E101 R170 BEFORE Arg1:E101 Arg2:E103 R171 BEFORE Arg1:E103 Arg2:E102 * OVERLAP E102 E100 E99 R172 BEFORE Arg1:E99 Arg2:E96 * OVERLAP E96 E97 E94 E98 E95 T244 Clinical_event 5114 5123 follow-up E127 Clinical_event:T244 R173 BEFORE Arg1:E95 Arg2:E127 * OVERLAP E127 E40 E41 E42 E43 E44 E45 E46 E47