--- a +++ b/processing/MACCROBAT/28353604.ann @@ -0,0 +1,474 @@ +T1 Sign_symptom 58 65 dyspnea +E1 Sign_symptom:T1 +T2 Detailed_description 47 57 exertional +R1 MODIFY Arg1:T2 Arg2:E1 +T3 Date 69 78 July 2010 +E2 Date:T3 +T4 Age 2 13 69-year-old +T5 Sex 14 17 man +T6 History 100 153 smoking for more than 40 years, 20 cigarettes per day +T7 Family_history 159 196 parents and 1 brother had lung cancer +T8 History 202 239 past medical history was unremarkable +T9 History 248 272 no occupational exposure +T10 Sign_symptom 296 303 dyspnea +E3 Sign_symptom:T10 +T11 Detailed_description 285 295 exertional +R2 MODIFY Arg1:T11 Arg2:E3 +T12 Clinical_event 312 320 admitted +E4 Clinical_event:T12 +T13 Nonbiological_location 328 364 People's Hospital of Shunde District +R3 MODIFY Arg1:T13 Arg2:E4 +T14 Diagnostic_procedure 369 385 echocardiography +E5 Diagnostic_procedure:T14 +T15 Diagnostic_procedure 390 431 computed tomography pulmonary angiography +E6 Diagnostic_procedure:T15 +T16 Diagnostic_procedure 433 437 CTPA +E7 Diagnostic_procedure:T16 +R4 IDENTICAL Arg1:E7 Arg2:E6 +T17 Diagnostic_procedure 440 456 Echocardiography +E8 Diagnostic_procedure:T17 +T18 Disease_disorder 486 489 PAH +E9 Disease_disorder:T18 +#1 AnnotatorNotes E9 Pulmonary arterial hypertension +T19 Severity 479 485 severe +R5 MODIFY Arg1:T19 Arg2:E9 +T20 Diagnostic_procedure 503 530 pulmonary arterial pressure +E10 Diagnostic_procedure:T20 +T21 Diagnostic_procedure 532 535 PAP +E11 Diagnostic_procedure:T21 +R6 IDENTICAL Arg1:E11 Arg2:E10 +T22 Lab_value 541 549 104 mmHg +R7 MODIFY Arg1:T22 Arg2:E10 +T23 Sign_symptom 575 583 enlarged +E12 Sign_symptom:T23 +T24 Biological_structure 559 570 right heart +R8 MODIFY Arg1:T24 Arg2:E12 +T25 Diagnostic_procedure 589 613 right ventricle diameter +E13 Diagnostic_procedure:T25 +T26 Lab_value 615 620 57 mm +R9 MODIFY Arg1:T26 Arg2:E13 +T27 Diagnostic_procedure 623 627 CTPA +E14 Diagnostic_procedure:T27 +T28 Disease_disorder 656 659 PAH +E15 Disease_disorder:T28 +T29 Disease_disorder 672 680 thrombus +E16 Disease_disorder:T29 +T30 Biological_structure 688 723 upper lobe artery of the right lung +R10 MODIFY Arg1:T30 Arg2:E16 +T31 Coreference 774 776 PE +E17 Coreference:T31 +#2 AnnotatorNotes E17 pulmonary embolism +T32 Biological_structure 738 756 region in the lung +R11 MODIFY Arg1:T32 Arg2:E17 +T33 History 847 937 did not have connective tissue disease, drug use, history of chemotherapy, or HIV test (+) +R12 IDENTICAL Arg1:E17 Arg2:E16 +T34 Disease_disorder 962 966 IPAH +E18 Disease_disorder:T34 +#3 AnnotatorNotes E18 Idiopathic pulmonary arterial hypertension +T35 Disease_disorder 981 983 PE +E19 Disease_disorder:T35 +#4 AnnotatorNotes E19 pulmonary embolism +T36 Medication 1005 1013 warfarin +E20 Medication:T36 +T37 Dosage 1015 1029 2.5 mg per day +R13 MODIFY Arg1:T37 Arg2:E20 +T38 Diagnostic_procedure 1051 1081 international normalized ratio +E21 Diagnostic_procedure:T38 +T39 Diagnostic_procedure 1083 1086 INR +E22 Diagnostic_procedure:T39 +R14 IDENTICAL Arg1:E22 Arg2:E21 +T40 Lab_value 1096 1107 1.5 and 2.5 +R15 MODIFY Arg1:T40 Arg2:E21 +T41 Medication 1113 1123 slidenafil +E23 Medication:T41 +T42 Dosage 1146 1165 20 mg twice per day +R16 MODIFY Arg1:T42 Arg2:E23 +T43 Sign_symptom 1182 1189 dyspnea +E24 Sign_symptom:T43 +A1 TREND E24 DEC +T44 Medication 1235 1246 medications +E25 Medication:T44 +T45 Duration 1251 1258 1 month +E26 Duration:T45 +T46 Diagnostic_procedure 1276 1279 PAP +E27 Diagnostic_procedure:T46 +T48 Lab_value 1304 1313 decreased +T49 Lab_value 1317 1324 72 mmHg +R18 MODIFY Arg1:T48 Arg2:E27 +R19 MODIFY Arg1:T49 Arg2:E27 +T50 Sign_symptom 1338 1362 other symptoms and signs +E29 Sign_symptom:T50 +T51 Lab_value 1363 1388 failed to further improve +R20 MODIFY Arg1:T51 Arg2:E29 +T52 Medication 1408 1419 medications +E30 Medication:T52 +T53 Duration 1424 1432 6 months +E31 Duration:T53 +T54 Date 1437 1447 March 2011 +E32 Date:T54 +T55 Clinical_event 1452 1456 went +E33 Clinical_event:T55 +T56 Nonbiological_location 1464 1501 Kyorin University affiliated hospital +R21 MODIFY Arg1:T56 Arg2:E33 +T57 Nonbiological_location 1505 1510 Japan +R22 MODIFY Arg1:T57 Arg2:T56 +T58 Diagnostic_procedure 1546 1561 catheterization +E34 Diagnostic_procedure:T58 +T59 Biological_structure 1534 1545 Right heart +R23 MODIFY Arg1:T59 Arg2:E34 +T60 Diagnostic_procedure 1571 1574 PAP +E35 Diagnostic_procedure:T60 +T61 Lab_value 1575 1588 72/34/47 mmHg +R24 MODIFY Arg1:T61 Arg2:E35 +T62 Diagnostic_procedure 1590 1624 pulmonary capillary wedge pressure +E36 Diagnostic_procedure:T62 +T63 Diagnostic_procedure 1626 1630 PCWP +E37 Diagnostic_procedure:T63 +R25 IDENTICAL Arg1:E37 Arg2:E36 +T64 Lab_value 1632 1644 17/5/10 mmHg +R26 MODIFY Arg1:T64 Arg2:E36 +T65 Diagnostic_procedure 1646 1660 cardiac output +E38 Diagnostic_procedure:T65 +T66 Lab_value 1661 1670 4.3 L/min +R27 MODIFY Arg1:T66 Arg2:E38 +T67 Diagnostic_procedure 1672 1694 cardiac ejection index +E39 Diagnostic_procedure:T67 +T68 Lab_value 1695 1708 2.36 L/min/m2 +R28 MODIFY Arg1:T68 Arg2:E39 +T69 Diagnostic_procedure 1714 1743 pulmonary vascular resistance +E40 Diagnostic_procedure:T69 +T70 Diagnostic_procedure 1780 1784 CTPA +E41 Diagnostic_procedure:T70 +T71 Disease_disorder 1806 1814 thrombus +E42 Disease_disorder:T71 +A2 POLARITY E42 NEG +T72 Biological_structure 1822 1857 upper lobe artery of the right lung +R29 MODIFY Arg1:T72 Arg2:E42 +T73 Disease_disorder 1904 1908 IPAH +E43 Disease_disorder:T73 +T74 Medication 1926 1936 sildenafil +E44 Medication:T74 +T75 Dosage 1938 1957 20 mg 3 times a day +R30 MODIFY Arg1:T75 Arg2:E44 +T76 Medication 1963 1972 sorafenib +E45 Medication:T76 +T77 Dosage 1974 1991 400 mg once a day +R31 MODIFY Arg1:T77 Arg2:E45 +T78 Therapeutic_procedure 2002 2013 PAH therapy +E46 Therapeutic_procedure:T78 +R32 SUB_PROCEDURE Arg1:E45 Arg2:E46 +R33 SUB_PROCEDURE Arg1:E44 Arg2:E46 +T79 Medication 2023 2031 warfarin +E47 Medication:T79 +T80 Therapeutic_procedure 2032 2055 anticoagulation therapy +E48 Therapeutic_procedure:T80 +R34 SUB_PROCEDURE Arg1:E47 Arg2:E48 +T81 Administration 2018 2022 oral +R35 MODIFY Arg1:T81 Arg2:E47 +T82 Dosage 2057 2076 2.5–3.75 mg per day +R36 MODIFY Arg1:T82 Arg2:E47 +T83 Diagnostic_procedure 2113 2116 INR +E49 Diagnostic_procedure:T83 +T84 Lab_value 2134 2141 2 and 3 +R37 MODIFY Arg1:T84 Arg2:E49 +T85 Sign_symptom 2165 2172 dyspnea +E50 Sign_symptom:T85 +T86 Diagnostic_procedure 2198 2201 PAP +E51 Diagnostic_procedure:T86 +T87 Lab_value 2237 2251 around 95 mmHg +R38 MODIFY Arg1:T87 Arg2:E51 +T47 Detailed_description 1283 1299 echocardiography +R17 MODIFY Arg1:T47 Arg2:E27 +T88 Detailed_description 2216 2232 echocardiography +R39 MODIFY Arg1:T88 Arg2:E51 +T89 Date 2256 2270 September 2011 +E28 Date:T89 +T90 Clinical_event 2275 2282 visited +E52 Clinical_event:T90 +T91 Nonbiological_location 2287 2314 Shanghai Pulmonary hospital +R40 MODIFY Arg1:T91 Arg2:E52 +T92 Nonbiological_location 2318 2323 China +R41 MODIFY Arg1:T92 Arg2:T91 +T93 Sign_symptom 2348 2355 dyspnea +E53 Sign_symptom:T93 +T94 Diagnostic_procedure 2357 2384 Arterial blood gas analysis +E54 Diagnostic_procedure:T94 +T95 Diagnostic_procedure 2397 2401 PaO2 +E55 Diagnostic_procedure:T95 +T96 Lab_value 2406 2413 63 mmHg +R42 MODIFY Arg1:T96 Arg2:E55 +R43 SUB_PROCEDURE Arg1:E55 Arg2:E54 +T97 Diagnostic_procedure 2419 2436 oxygen saturation +E56 Diagnostic_procedure:T97 +T98 Lab_value 2437 2440 93% +R44 MODIFY Arg1:T98 Arg2:E56 +R45 SUB_PROCEDURE Arg1:E56 Arg2:E54 +T99 Diagnostic_procedure 2442 2460 lung function test +E57 Diagnostic_procedure:T99 +T100 Disease_disorder 2477 2500 obstructive dysfunction +E58 Disease_disorder:T100 +T101 Severity 2472 2476 mild +R46 MODIFY Arg1:T101 Arg2:E58 +T102 Detailed_description 2508 2529 pulmonary ventilation +R47 MODIFY Arg1:T102 Arg2:E58 +T103 Diagnostic_procedure 2531 2539 FEV1/FVC +E59 Diagnostic_procedure:T103 +T104 Lab_value 2540 2546 62.06% +R48 MODIFY Arg1:T104 Arg2:E59 +T105 Diagnostic_procedure 2548 2553 FEV1% +E60 Diagnostic_procedure:T105 +T106 Lab_value 2565 2570 80.9% +R49 MODIFY Arg1:T106 Arg2:E60 +T107 Detailed_description 2554 2564 Prediction +R50 MODIFY Arg1:T107 Arg2:E60 +T108 Diagnostic_procedure 2655 2659 DLCO +E61 Diagnostic_procedure:T108 +T109 Diagnostic_procedure 2602 2653 diffusing capacity of the lungs for carbon monoxide +E62 Diagnostic_procedure:T109 +T110 Lab_value 2585 2594 reduction +R51 MODIFY Arg1:T110 Arg2:E62 +R52 IDENTICAL Arg1:E61 Arg2:E62 +T111 Lab_value 2660 2663 42% +R53 MODIFY Arg1:T111 Arg2:E62 +T112 Diagnostic_procedure 2675 2684 walk test +E63 Diagnostic_procedure:T112 +T113 Detailed_description 2666 2674 6-minute +R54 MODIFY Arg1:T113 Arg2:E63 +T114 Lab_value 2689 2694 385 m +R55 MODIFY Arg1:T114 Arg2:E63 +T115 Diagnostic_procedure 2739 2743 HRCT +E64 Diagnostic_procedure:T115 +T116 Diagnostic_procedure 2702 2737 high-resolution computed tomography +E65 Diagnostic_procedure:T116 +R56 IDENTICAL Arg1:E64 Arg2:E65 +T117 Biological_structure 2696 2701 Chest +R57 MODIFY Arg1:T117 Arg2:E65 +T119 Biological_structure 2788 2806 interlobular septa +T120 Sign_symptom 2830 2837 nodules +E66 Sign_symptom:T120 +T121 Sign_symptom 2847 2858 enlargement +E67 Sign_symptom:T121 +T122 Biological_structure 2862 2885 mediastinal lymph nodes +R60 MODIFY Arg1:T122 Arg2:E67 +T118 Sign_symptom 2774 2784 thickening +E68 Sign_symptom:T118 +T123 Texture 2767 2773 smooth +R58 MODIFY Arg1:T123 Arg2:E68 +R59 MODIFY Arg1:T119 Arg2:E68 +T124 Detailed_description 2808 2815 diffuse +T125 Biological_structure 2816 2829 centrilobular +R61 MODIFY Arg1:T125 Arg2:E66 +R62 MODIFY Arg1:T124 Arg2:E66 +T126 Diagnostic_procedure 2903 2918 catheterization +E69 Diagnostic_procedure:T126 +T127 Biological_structure 2891 2902 right heart +R63 MODIFY Arg1:T127 Arg2:E69 +T128 Diagnostic_procedure 2933 2936 PAP +E70 Diagnostic_procedure:T128 +T129 Lab_value 2941 2954 83/34/53 mmHg +R64 MODIFY Arg1:T129 Arg2:E70 +T130 Diagnostic_procedure 2959 2963 PCWP +E71 Diagnostic_procedure:T130 +T131 Lab_value 2968 2980 14/6/11 mmHg +R65 MODIFY Arg1:T131 Arg2:E71 +T132 Diagnostic_procedure 2982 3007 Acute vasodilator testing +E72 Diagnostic_procedure:T132 +T133 Lab_value 3012 3020 negative +R66 MODIFY Arg1:T133 Arg2:E72 +T134 Diagnostic_procedure 3022 3042 Coronary angiography +E73 Diagnostic_procedure:T134 +T135 Diagnostic_procedure 3047 3051 CTPA +E74 Diagnostic_procedure:T135 +T136 Lab_value 3062 3068 normal +R67 MODIFY Arg1:T136 Arg2:E74 +R68 MODIFY Arg1:T136 Arg2:E73 +T137 Diagnostic_procedure 3080 3101 ventilation/perfusion +E75 Diagnostic_procedure:T137 +T138 Diagnostic_procedure 3103 3108 V’/Q’ +E76 Diagnostic_procedure:T138 +R69 IDENTICAL Arg1:E76 Arg2:E75 +T139 Biological_structure 3070 3079 pulmonary +R70 MODIFY Arg1:T139 Arg2:E75 +T140 Biological_structure 3110 3114 lung +R71 MODIFY Arg1:T140 Arg2:E75 +T141 Sign_symptom 3129 3170 matched ventilation and perfusion defects +E77 Sign_symptom:T141 +T142 Diagnostic_procedure 3172 3194 Bronchoalveolar lavage +E78 Diagnostic_procedure:T142 +T143 Lab_value 3205 3213 elevated +T144 Lab_value 3226 3229 65% +R72 MODIFY Arg1:T143 Arg2:E78 +R73 MODIFY Arg1:T144 Arg2:E78 +T145 Biological_structure 3234 3263 hemosiderin-laden macrophages +R74 MODIFY Arg1:T145 Arg2:T143 +R75 MODIFY Arg1:T145 Arg2:T144 +T146 Diagnostic_procedure 3273 3284 Golde score +E79 Diagnostic_procedure:T146 +T147 Lab_value 3285 3287 80 +R76 MODIFY Arg1:T147 Arg2:E79 +R77 SUB_PROCEDURE Arg1:E79 Arg2:E78 +T148 Disease_disorder 3347 3351 IPAH +E80 Disease_disorder:T148 +T149 Disease_disorder 3393 3397 PVOD +E81 Disease_disorder:T149 +A3 POLARITY E81 UNCERTAIN +#5 AnnotatorNotes E81 Pulmonary veno-occlusive disease +T150 Therapeutic_procedure 3445 3456 PAH therapy +E82 Therapeutic_procedure:T150 +T151 Therapeutic_procedure 3491 3516 anticoagulation treatment +E83 Therapeutic_procedure:T151 +T152 Medication 3533 3541 warfarin +E84 Medication:T152 +A4 POLARITY E84 NEG +T153 Detailed_description 3568 3578 by himself +R78 MODIFY Arg1:T153 Arg2:E84 +T154 Date 3579 3595 sometime in 2014 +E85 Date:T154 +T155 Diagnostic_procedure 3813 3828 monitor D-Dimer +E86 Diagnostic_procedure:T155 +A5 POLARITY E86 NEG +T156 Sign_symptom 3859 3866 dyspnea +E87 Sign_symptom:T156 +T157 Disease_disorder 3940 3955 pulmonary edema +E88 Disease_disorder:T157 +T158 Severity 3917 3926 not fatal +R79 MODIFY Arg1:T158 Arg2:E88 +T159 Detailed_description 3907 3911 many +R80 MODIFY Arg1:T159 Arg2:E88 +T160 Date 3979 3991 January 2015 +E89 Date:T160 +T161 Clinical_event 4000 4006 rushed +E90 Clinical_event:T161 +T162 Nonbiological_location 4010 4018 hospital +R81 MODIFY Arg1:T162 Arg2:E90 +T163 Sign_symptom 4031 4038 dyspnea +E91 Sign_symptom:T163 +T164 Detailed_description 4052 4063 exacerbated +R82 MODIFY Arg1:T164 Arg2:E91 +T165 Lab_value 3882 3888 stable +R83 MODIFY Arg1:T165 Arg2:E87 +T166 Diagnostic_procedure 4065 4069 CTPA +E92 Diagnostic_procedure:T166 +T167 Disease_disorder 4079 4087 thrombus +E93 Disease_disorder:T167 +T168 Biological_structure 4095 4122 right main pulmonary artery +R84 MODIFY Arg1:T168 Arg2:E93 +T169 Medication 4133 4144 Rivaroxaban +E94 Medication:T169 +T170 Therapeutic_procedure 4166 4191 anticoagulation treatment +E95 Therapeutic_procedure:T170 +T171 Sign_symptom 4233 4240 dyspnea +E96 Sign_symptom:T171 +T172 Sign_symptom 4260 4275 too ill to walk +E97 Sign_symptom:T172 +T173 Duration 4321 4332 half a year +E98 Duration:T173 +T174 Activity 4293 4316 bound to his wheelchair +E99 Activity:T174 +T175 Disease_disorder 4345 4348 PAH +E100 Disease_disorder:T175 +T176 Disease_disorder 4363 4367 PVOD +E101 Disease_disorder:T176 +A6 POLARITY E101 MAYBE_POS +T177 Disease_disorder 4402 4404 PE +E102 Disease_disorder:T177 +T178 Severity 4385 4401 life-threatening +R85 MODIFY Arg1:T178 Arg2:E102 +T179 Therapeutic_procedure 4416 4436 lung transplantation +E103 Therapeutic_procedure:T179 +T180 Date 4455 4471 Six months later +E104 Date:T180 +T181 Therapeutic_procedure 4523 4543 lung transplantation +E105 Therapeutic_procedure:T181 +T182 Detailed_description 4513 4522 allogenic +T183 Detailed_description 4502 4512 sequential +T184 Detailed_description 4492 4501 bilateral +R86 MODIFY Arg1:T182 Arg2:E105 +R87 MODIFY Arg1:T183 Arg2:E105 +R88 MODIFY Arg1:T184 Arg2:E105 +T185 Therapeutic_procedure 4556 4606 veno-arterial extra-corporeal membrane oxygenation +E106 Therapeutic_procedure:T185 +T186 Therapeutic_procedure 4608 4615 VA-ECMO +E107 Therapeutic_procedure:T186 +R89 IDENTICAL Arg1:E107 Arg2:E106 +T187 Date 4656 4669 July 29, 2015 +E108 Date:T187 +T188 Diagnostic_procedure 4671 4680 Histology +E109 Diagnostic_procedure:T188 +T189 Biological_structure 4688 4711 explanted lung specimen +R90 MODIFY Arg1:T189 Arg2:E109 +T191 Disease_disorder 4852 4856 PVOD +E110 Disease_disorder:T191 +T192 Disease_disorder 4871 4873 PE +E111 Disease_disorder:T192 +T193 Disease_disorder 4886 4890 IPAH +E112 Disease_disorder:T193 +A7 POLARITY E112 NEG +T190 Lab_value 4734 4743 occlusion +T194 Biological_structure 4719 4733 pulmonary vein +R91 MODIFY Arg1:T194 Arg2:T190 +R92 MODIFY Arg1:T190 Arg2:E109 +T195 Lab_value 4773 4781 embolism +T196 Biological_structure 4763 4772 pulmonary +R93 MODIFY Arg1:T196 Arg2:T195 +T197 Biological_structure 4789 4811 right pulmonary artery +R94 MODIFY Arg1:T197 Arg2:T195 +R95 MODIFY Arg1:T195 Arg2:E109 +T198 Sign_symptom 4911 4915 well +E113 Sign_symptom:T198 +T199 Sign_symptom 4924 4931 dyspnea +E114 Sign_symptom:T199 +A8 POLARITY E114 NEG +T200 Duration 4936 4952 more than 1 year +E115 Duration:T200 +T201 Diagnostic_procedure 4992 5008 echocardiography +E116 Diagnostic_procedure:T201 +T202 Diagnostic_procedure 5038 5041 PAP +E117 Diagnostic_procedure:T202 +T203 Lab_value 5020 5034 normalizations +R96 MODIFY Arg1:T203 Arg2:E117 +T204 Sign_symptom 5055 5063 enlarged +E118 Sign_symptom:T204 +A9 POLARITY E118 NEG +T205 Biological_structure 5064 5092 right ventricle of his heart +R97 MODIFY Arg1:T205 Arg2:E118 +* OVERLAP E1 E2 E3 +R98 BEFORE Arg1:E3 Arg2:E4 +* OVERLAP E4 E5 E6 E8 E9 E10 E12 E13 E14 E15 E16 E17 E18 E19 +R99 BEFORE Arg1:E19 Arg2:E20 +* OVERLAP E20 E21 E23 +R100 BEFORE Arg1:E23 Arg2:E24 +* OVERLAP E24 E25 E26 E27 +R101 BEFORE Arg1:E27 Arg2:E29 +* OVERLAP E29 E30 E31 +R102 BEFORE Arg1:E31 Arg2:E32 +* OVERLAP E32 E33 E34 E35 E36 E38 E39 E40 E41 E42 E43 +T206 Lab_value 1744 1758 7.3 Wood units +R103 MODIFY Arg1:T206 Arg2:E40 +R104 BEFORE Arg1:E43 Arg2:E46 +* OVERLAP E46 E48 E49 +R105 BEFORE Arg1:E49 Arg2:E50 +* OVERLAP E50 E51 +R106 BEFORE Arg1:E51 Arg2:E28 +* OVERLAP E28 E52 E53 E54 E57 E58 E59 E60 E62 E63 E65 E68 E66 E67 E69 E70 E71 E72 E73 E75 E77 E78 E80 E81 +R107 BEFORE Arg1:E81 Arg2:E82 +* OVERLAP E82 E83 +R108 BEFORE Arg1:E83 Arg2:E84 +* OVERLAP E84 E85 +R109 BEFORE Arg1:E85 Arg2:E86 +* OVERLAP E86 E87 E88 +R110 BEFORE Arg1:E88 Arg2:E89 +* OVERLAP E89 E90 E91 E92 E93 +R111 BEFORE Arg1:E93 Arg2:E94 +* OVERLAP E94 E95 E96 E97 +R112 BEFORE Arg1:E97 Arg2:E99 +* OVERLAP E99 E98 +R113 BEFORE Arg1:E98 Arg2:E100 +* OVERLAP E100 E101 E102 +R114 BEFORE Arg1:E102 Arg2:E103 +* OVERLAP E103 E104 E105 E106 E108 +R115 BEFORE Arg1:E108 Arg2:E109 +R116 BEFORE Arg1:E109 Arg2:E110 +* OVERLAP E110 E111 E112 +R117 BEFORE Arg1:E112 Arg2:E113 +* OVERLAP E113 E114 E115 E116 E117 E118