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T1 Age 2 13 75-year-old T2 Sex 14 17 man T3 Clinical_event 22 30 referred E1 Clinical_event:T3 T4 Nonbiological_location 38 46 hospital R1 MODIFY Arg1:T4 Arg2:E1 T5 Sign_symptom 69 78 dysphagia E2 Sign_symptom:T5 T6 Sign_symptom 123 129 nausea E3 Sign_symptom:T6 T7 Duration 83 91 9 months E4 Duration:T7 T8 Sign_symptom 134 142 vomiting E5 Sign_symptom:T8 T9 Sign_symptom 154 165 hematemesis E6 Sign_symptom:T9 A1 POLARITY E6 NEG T10 Sign_symptom 167 179 hematochezia E7 Sign_symptom:T10 A2 POLARITY E7 NEG T11 Sign_symptom 181 189 lethargy E8 Sign_symptom:T11 A3 POLARITY E8 NEG T12 Sign_symptom 195 202 dyspnea E9 Sign_symptom:T12 A4 POLARITY E9 NEG T13 History 214 227 active smoker T14 Diagnostic_procedure 263 283 Physical examination E10 Diagnostic_procedure:T14 T15 Sign_symptom 307 322 lymphadenopathy E11 Sign_symptom:T15 A5 POLARITY E11 NEG T16 Sign_symptom 324 335 thyromegaly E12 Sign_symptom:T16 A6 POLARITY E12 NEG T17 Sign_symptom 337 344 ascites E13 Sign_symptom:T17 A7 POLARITY E13 NEG T18 Sign_symptom 349 353 mass E14 Sign_symptom:T18 A8 POLARITY E14 NEG T19 Biological_structure 361 368 abdomen R2 MODIFY Arg1:T19 Arg2:E14 T20 Detailed_description 296 306 peripheral R3 MODIFY Arg1:T20 Arg2:E11 T21 Diagnostic_procedure 370 385 Laboratory data E15 Diagnostic_procedure:T21 T22 Lab_value 391 397 normal R4 MODIFY Arg1:T22 Arg2:E15 T23 Diagnostic_procedure 399 405 HBs-Ag E16 Diagnostic_procedure:T23 T24 Diagnostic_procedure 416 419 HIV E17 Diagnostic_procedure:T24 T25 Diagnostic_procedure 434 442 syphilis E18 Diagnostic_procedure:T25 T26 Lab_value 406 414 negative R5 MODIFY Arg1:T26 Arg2:E16 T27 Lab_value 420 428 negative R6 MODIFY Arg1:T27 Arg2:E17 T28 Lab_value 443 451 negative R7 MODIFY Arg1:T28 Arg2:E18 R8 SUB_PROCEDURE Arg1:E16 Arg2:E15 R9 SUB_PROCEDURE Arg1:E17 Arg2:E15 R10 SUB_PROCEDURE Arg1:E18 Arg2:E15 T29 Diagnostic_procedure 462 504 serum antibody against Helicobacter pylori E19 Diagnostic_procedure:T29 T30 Lab_value 509 517 negative R11 MODIFY Arg1:T30 Arg2:E19 T31 Diagnostic_procedure 525 544 computed tomography E20 Diagnostic_procedure:T31 T32 Diagnostic_procedure 546 548 CT E21 Diagnostic_procedure:T32 R12 IDENTICAL Arg1:E21 Arg2:E20 T33 Biological_structure 519 524 Chest R13 MODIFY Arg1:T33 Arg2:E20 T34 Sign_symptom 632 640 neoplasm E22 Sign_symptom:T34 T35 Detailed_description 568 572 huge R14 MODIFY Arg1:T35 Arg2:E22 T36 Detailed_description 573 591 well-circumscribed R15 MODIFY Arg1:T36 Arg2:E22 T37 Detailed_description 596 607 homogeneous R16 MODIFY Arg1:T37 Arg2:E22 T38 Shape 608 619 cylindrical R17 MODIFY Arg1:T38 Arg2:E22 T39 Detailed_description 620 631 mesenchymal R18 MODIFY Arg1:T39 Arg2:E22 T40 Volume 651 666 15.5×5.9×4.0 cm R19 MODIFY Arg1:T40 Arg2:E22 T41 Biological_structure 670 696 lower and middle esophagus R20 MODIFY Arg1:T41 Arg2:E22 T42 Detailed_description 702 727 mild contrast enhancement R21 MODIFY Arg1:T42 Arg2:E20 T43 Diagnostic_procedure 738 740 CT E23 Diagnostic_procedure:T43 T44 Sign_symptom 753 766 abnormalities E24 Sign_symptom:T44 A9 POLARITY E24 NEG T45 Biological_structure 774 779 lungs T46 Biological_structure 781 786 heart T47 Biological_structure 788 792 ribs T48 Biological_structure 797 808 mediastinum R22 MODIFY Arg1:T45 Arg2:E24 R23 MODIFY Arg1:T46 Arg2:E24 R24 MODIFY Arg1:T47 Arg2:E24 R25 MODIFY Arg1:T48 Arg2:E24 T49 Diagnostic_procedure 810 832 Endoscopic examination E25 Diagnostic_procedure:T49 T50 Sign_symptom 853 859 lesion E26 Sign_symptom:T50 T51 Detailed_description 842 852 submucosal R26 MODIFY Arg1:T51 Arg2:E26 T52 Biological_structure 867 876 esophagus R27 MODIFY Arg1:T52 Arg2:E26 T53 Distance 889 917 20 cm from the incisor teeth R28 MODIFY Arg1:T53 Arg2:T52 T54 Biological_structure 928 944 up to the cardia R29 MODIFY Arg1:T54 Arg2:T52 T55 Diagnostic_procedure 955 981 Endoscopic ultrasonography E27 Diagnostic_procedure:T55 T56 Diagnostic_procedure 983 986 EUS E28 Diagnostic_procedure:T56 R30 IDENTICAL Arg1:E28 Arg2:E27 T57 Sign_symptom 1008 1014 lesion E29 Sign_symptom:T57 T58 Detailed_description 997 1007 hypoechoic R31 MODIFY Arg1:T58 Arg2:E29 T59 Detailed_description 1023 1036 lear boundary R32 MODIFY Arg1:T59 Arg2:E29 T60 Detailed_description 1052 1061 4th layer R33 MODIFY Arg1:T60 Arg2:E29 T61 Coreference 1067 1071 mass E30 Coreference:T61 R34 IDENTICAL Arg1:E30 Arg2:E29 T62 Sign_symptom 1086 1098 benign tumor E31 Sign_symptom:T62 T63 Disease_disorder 1135 1155 esophageal leiomyoma E32 Disease_disorder:T63 R35 MODIFY Arg1:E31 Arg2:E30 T64 Therapeutic_procedure 1236 1245 resection E33 Therapeutic_procedure:T64 A10 POLARITY E33 NEG T65 Therapeutic_procedure 1271 1280 resection E34 Therapeutic_procedure:T65 A11 POLARITY E34 NEG T66 Detailed_description 1260 1270 submucosal T67 Detailed_description 1249 1259 endoscopic T68 Detailed_description 1217 1227 Endoscopic T69 Detailed_description 1228 1235 mucosal R36 MODIFY Arg1:T69 Arg2:E33 R37 MODIFY Arg1:T68 Arg2:E33 R38 MODIFY Arg1:T66 Arg2:E34 R39 MODIFY Arg1:T67 Arg2:E34 T70 Therapeutic_procedure 1337 1346 resection E35 Therapeutic_procedure:T70 T71 Detailed_description 1328 1336 surgical R40 MODIFY Arg1:T71 Arg2:E35 T72 Therapeutic_procedure 1444 1453 resection E36 Therapeutic_procedure:T72 T73 Detailed_description 1421 1443 thoracoscopic-assisted R41 MODIFY Arg1:T73 Arg2:E36 T74 Coreference 1461 1465 mass E37 Coreference:T74 R42 IDENTICAL Arg1:E37 Arg2:E30 T75 Therapeutic_procedure 1488 1499 anastomosis E38 Therapeutic_procedure:T75 T76 Detailed_description 1471 1487 gastroesophageal R43 MODIFY Arg1:T76 Arg2:E38 T77 Therapeutic_procedure 1515 1523 ligation E39 Therapeutic_procedure:T77 R44 SUB_PROCEDURE Arg1:E38 Arg2:E36 R45 SUB_PROCEDURE Arg1:E39 Arg2:E36 T78 Biological_structure 1501 1514 thoracic duct R46 MODIFY Arg1:T78 Arg2:E39 T79 Therapeutic_procedure 1529 1540 jejunostomy E40 Therapeutic_procedure:T79 R47 SUB_PROCEDURE Arg1:E40 Arg2:E36 T80 Therapeutic_procedure 1542 1562 Postoperative course E41 Therapeutic_procedure:T80 T81 Lab_value 1567 1577 uneventful R48 MODIFY Arg1:T81 Arg2:E41 T82 Sign_symptom 1605 1609 lump E42 Sign_symptom:T82 T83 Shape 1590 1604 spindle shaped R49 MODIFY Arg1:T83 Arg2:E42 T84 Volume 1620 1637 14 × 3.5 × 2.5 cm R50 MODIFY Arg1:T84 Arg2:E42 T85 Biological_structure 1668 1677 esophagus R51 MODIFY Arg1:T85 Arg2:E42 T86 Biological_structure 1699 1715 esophageal lumen R52 MODIFY Arg1:T86 Arg2:T85 T87 Biological_structure 1736 1741 lumen R53 MODIFY Arg1:T87 Arg2:E43 T88 Sign_symptom 1720 1727 blocked E43 Sign_symptom:T88 R54 CAUSE Arg1:E42 Arg2:E43 T89 Coreference 1748 1752 lump E44 Coreference:T89 R55 IDENTICAL Arg1:E44 Arg2:E42 T90 Biological_structure 1768 1777 submucosa R56 MODIFY Arg1:T90 Arg2:E44 T91 Detailed_description 1782 1808 covered with intact mucosa R57 MODIFY Arg1:T91 Arg2:E44 T92 Sign_symptom 1818 1825 erosion E45 Sign_symptom:T92 A12 POLARITY E45 NEG T93 Disease_disorder 1827 1832 ulcer E46 Disease_disorder:T93 A13 POLARITY E46 NEG T94 Disease_disorder 1838 1848 hemorrhage E47 Disease_disorder:T94 A14 POLARITY E47 NEG R58 MODIFY Arg1:E44 Arg2:E45 R59 MODIFY Arg1:E44 Arg2:E46 R60 MODIFY Arg1:E44 Arg2:E47 T95 Color 1870 1888 homogenously white T96 Color 1892 1905 grayish-white R61 MODIFY Arg1:T95 Arg2:E44 R62 MODIFY Arg1:T96 Arg2:E44 T97 Diagnostic_procedure 1916 1940 Histological examination E48 Diagnostic_procedure:T97 T98 Diagnostic_procedure 1947 1958 hematoxylin E49 Diagnostic_procedure:T98 T99 Diagnostic_procedure 1963 1977 eosin staining E50 Diagnostic_procedure:T99 R63 SUB_PROCEDURE Arg1:E49 Arg2:E48 R64 SUB_PROCEDURE Arg1:E50 Arg2:E48 T100 Coreference 1992 1997 tumor E51 Coreference:T100 R65 IDENTICAL Arg1:E51 Arg2:E44 T101 Detailed_description 2002 2041 covered with intact squamous epithelium R66 MODIFY Arg1:T101 Arg2:E51 T102 Biological_structure 2051 2076 from the submucosal layer T103 Biological_structure 2101 2115 muscular layer R67 MODIFY Arg1:T102 Arg2:T101 R68 MODIFY Arg1:T103 Arg2:T101 T104 Coreference 2121 2126 tumor E52 Coreference:T104 R69 IDENTICAL Arg1:E52 Arg2:E51 T105 Detailed_description 2131 2201 composed of many nodules of varying sizes separated by collagen fibers R70 MODIFY Arg1:T105 Arg2:E52 T106 Detailed_description 2203 2305 Numerous cytoplasm-rich cells were observed in the collagenous septations with invasive growth pattern R71 MODIFY Arg1:T106 Arg2:E52 T107 Detailed_description 2322 2439 nodules were mainly composed of small to mid-sized centrocyte-like or monocyte-like cells arranged in diffuse pattern R72 MODIFY Arg1:T107 Arg2:T105 R73 MODIFY Arg1:T106 Arg2:T105 T108 Detailed_description 2447 2467 atypical lymphocytes R74 MODIFY Arg1:T108 Arg2:T107 T109 Detailed_description 2478 2492 clear boundary T110 Detailed_description 2494 2508 pale cytoplasm T111 Detailed_description 2510 2527 irregular nucleus T112 Detailed_description 2533 2553 occasional nucleolus R75 MODIFY Arg1:T109 Arg2:T108 R76 MODIFY Arg1:T110 Arg2:T108 R77 MODIFY Arg1:T111 Arg2:T108 R78 MODIFY Arg1:T112 Arg2:T108 T113 Diagnostic_procedure 2564 2571 Mitosis E53 Diagnostic_procedure:T113 T114 Lab_value 2576 2580 rare R79 MODIFY Arg1:T114 Arg2:E53 T115 Sign_symptom 2602 2608 lesion E54 Sign_symptom:T115 A15 POLARITY E54 NEG T116 Coreference 2631 2637 lesion E55 Coreference:T116 R80 IDENTICAL Arg1:E55 Arg2:E52 T117 Detailed_description 2585 2601 lymphoepithelial R81 MODIFY Arg1:T117 Arg2:E54 R82 MODIFY Arg1:E55 Arg2:E54 T118 Diagnostic_procedure 2642 2670 immunohistochemical staining E56 Diagnostic_procedure:T118 T119 Diagnostic_procedure 2710 2721 cytokeratin E57 Diagnostic_procedure:T119 T120 Biological_structure 2672 2682 epithelium R83 MODIFY Arg1:T120 Arg2:T121 T121 Lab_value 2687 2705 diffusely positive R84 MODIFY Arg1:T121 Arg2:E57 R85 SUB_PROCEDURE Arg1:E57 Arg2:E56 T122 Diagnostic_procedure 2780 2813 cluster of differentiation (CD)20 E58 Diagnostic_procedure:T122 T123 Lab_value 2757 2775 diffusely positive T124 Coreference 2740 2751 tumor cells E59 Coreference:T124 R86 IDENTICAL Arg1:E59 Arg2:E55 T125 Diagnostic_procedure 2815 2827 paired box 5 E60 Diagnostic_procedure:T125 T126 Diagnostic_procedure 2842 2865 B-cell lymphoma (Bcl)-2 E61 Diagnostic_procedure:T126 R88 MODIFY Arg1:T123 Arg2:E58 R89 MODIFY Arg1:T123 Arg2:E60 R90 MODIFY Arg1:T123 Arg2:E61 R92 MODIFY Arg1:E59 Arg2:T123 R93 SUB_PROCEDURE Arg1:E58 Arg2:E56 R94 SUB_PROCEDURE Arg1:E60 Arg2:E56 R95 SUB_PROCEDURE Arg1:E61 Arg2:E56 T127 Diagnostic_procedure 2979 3006 multiple myeloma oncogene 1 E62 Diagnostic_procedure:T127 T128 Diagnostic_procedure 3008 3013 CD138 E63 Diagnostic_procedure:T128 T129 Diagnostic_procedure 3019 3023 CD43 E64 Diagnostic_procedure:T129 T130 Lab_value 2966 2974 positive R96 MODIFY Arg1:T130 Arg2:E62 R97 MODIFY Arg1:T130 Arg2:E63 R98 MODIFY Arg1:T130 Arg2:E64 T131 Biological_structure 2876 2905 Small deposits of tumor cells T132 Detailed_description 2930 2959 mainly in the collagen fibers R99 MODIFY Arg1:T132 Arg2:T131 R102 MODIFY Arg1:T131 Arg2:T130 R103 SUB_PROCEDURE Arg1:E62 Arg2:E56 R104 SUB_PROCEDURE Arg1:E63 Arg2:E56 R105 SUB_PROCEDURE Arg1:E64 Arg2:E56 T133 Diagnostic_procedure 3068 3072 CD30 E65 Diagnostic_procedure:T133 T134 Lab_value 3055 3063 positive T135 Biological_structure 3025 3044 Several tumor cells R106 MODIFY Arg1:T135 Arg2:T134 R107 MODIFY Arg1:T134 Arg2:E65 T136 Diagnostic_procedure 3110 3113 CD3 E66 Diagnostic_procedure:T136 R108 SUB_PROCEDURE Arg1:E65 Arg2:E56 T137 Lab_value 3097 3105 positive T138 Diagnostic_procedure 3118 3121 CD5 E67 Diagnostic_procedure:T138 R109 MODIFY Arg1:T137 Arg2:E66 R110 MODIFY Arg1:T137 Arg2:E67 T139 Biological_structure 3074 3091 Small lymphocytes T140 Lab_value 3155 3163 positive T141 Diagnostic_procedure 3168 3172 CD21 E68 Diagnostic_procedure:T141 T142 Diagnostic_procedure 3177 3181 CD23 E69 Diagnostic_procedure:T142 R87 MODIFY Arg1:T140 Arg2:E68 R91 MODIFY Arg1:T140 Arg2:E69 T143 Biological_structure 3123 3149 Follicular dendritic cells R100 MODIFY Arg1:T139 Arg2:T137 R101 MODIFY Arg1:T143 Arg2:T140 R111 SUB_PROCEDURE Arg1:E66 Arg2:E56 R112 SUB_PROCEDURE Arg1:E67 Arg2:E56 R113 SUB_PROCEDURE Arg1:E68 Arg2:E56 R114 SUB_PROCEDURE Arg1:E69 Arg2:E56 T144 Diagnostic_procedure 3220 3228 CyclinD1 E70 Diagnostic_procedure:T144 T145 Diagnostic_procedure 3230 3234 CD10 E71 Diagnostic_procedure:T145 T146 Diagnostic_procedure 3236 3241 Bcl-6 E72 Diagnostic_procedure:T146 T147 Diagnostic_procedure 3247 3304 B lymphocyte specific activation of OCT binding protein 1 E73 Diagnostic_procedure:T147 T148 Biological_structure 3192 3201 All cells T149 Lab_value 3207 3215 negative R115 MODIFY Arg1:T148 Arg2:T149 R116 SUB_PROCEDURE Arg1:E70 Arg2:E56 R117 SUB_PROCEDURE Arg1:E71 Arg2:E56 R118 SUB_PROCEDURE Arg1:E72 Arg2:E56 R119 SUB_PROCEDURE Arg1:E73 Arg2:E56 T150 Clinical_event 4423 4432 follow-up E74 Clinical_event:T150 T151 Disease_disorder 3489 3502 MALT lymphoma E75 Disease_disorder:T151 T152 Diagnostic_procedure 3518 3559 gene rearragements and clonality analysis E76 Diagnostic_procedure:T152 T153 Diagnostic_procedure 3563 3594 immunoglobulin heavy chain gene E77 Diagnostic_procedure:T153 T154 Diagnostic_procedure 3596 3618 kappa light chain gene E78 Diagnostic_procedure:T154 T155 Diagnostic_procedure 3624 3647 lambda light chain gene E79 Diagnostic_procedure:T155 T156 Detailed_description 3672 3718 IdentiCloneTM IGH/IGK/IGL Gene Clonality Assay T157 Detailed_description 3720 3749 InVivoScribe Technologies, CA R120 MODIFY Arg1:T157 Arg2:T156 R121 MODIFY Arg1:T156 Arg2:E76 R122 SUB_PROCEDURE Arg1:E77 Arg2:E76 R123 SUB_PROCEDURE Arg1:E78 Arg2:E76 R124 SUB_PROCEDURE Arg1:E79 Arg2:E76 T158 Disease_disorder 4006 4024 Epstein–Barr virus E80 Disease_disorder:T158 A16 POLARITY E80 NEG T159 Disease_disorder 4264 4277 MALT lymphoma E81 Disease_disorder:T159 T160 Biological_structure 4253 4263 esophageal T161 Detailed_description 4245 4252 primary R125 MODIFY Arg1:T160 Arg2:E81 R126 MODIFY Arg1:T161 Arg2:E81 T162 Therapeutic_procedure 4307 4316 resection E82 Therapeutic_procedure:T162 T163 Detailed_description 4298 4306 surgical R127 MODIFY Arg1:T163 Arg2:E82 T164 Therapeutic_procedure 4371 4383 radiotherapy E83 Therapeutic_procedure:T164 T165 Therapeutic_procedure 4332 4339 therapy E84 Therapeutic_procedure:T165 T166 Medication 4355 4367 chemotherapy E85 Medication:T166 A17 POLARITY E84 NEG A18 POLARITY E85 NEG A19 POLARITY E83 NEG T167 Sign_symptom 4449 4459 recurrence E86 Sign_symptom:T167 A20 POLARITY E86 NEG T168 Sign_symptom 4463 4473 metastases E87 Sign_symptom:T168 A21 POLARITY E87 NEG T169 Diagnostic_procedure 4487 4489 CT E88 Diagnostic_procedure:T169 T170 Sign_symptom 4515 4527 asymptomatic E89 Sign_symptom:T170 T171 Coreference 3839 3855 heavy chain gene E90 Coreference:T171 T172 Coreference 3898 3920 kappa light chain gene E91 Coreference:T172 T173 Coreference 3957 3980 lambda light chain gene E92 Coreference:T173 R128 IDENTICAL Arg1:E90 Arg2:E77 R129 IDENTICAL Arg1:E91 Arg2:E78 R130 IDENTICAL Arg1:E92 Arg2:E79 T174 Lab_value 3786 3830 1 band appeared within 150 to 175 base pairs T175 Lab_value 3857 3894 2 discrete bands within 225 to 250 bp T176 Lab_value 3926 3953 1 band within 125 to 150 bp R131 MODIFY Arg1:T174 Arg2:E90 R132 MODIFY Arg1:T175 Arg2:E91 R133 MODIFY Arg1:T176 Arg2:E92 T177 Diagnostic_procedure 4058 4079 in situ hybridization E93 Diagnostic_procedure:T177 T178 Detailed_description 4090 4116 EB virus-encoded small RNA R134 MODIFY Arg1:T178 Arg2:E93 R135 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E4 R136 BEFORE Arg1:E4 Arg2:E3 * OVERLAP E3 E5 E6 E7 E8 E9 E10 E11 E12 E13 E14 E15 E19 E20 E22 E23 E24 E25 E26 E27 E29 E31 E32 R137 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 R138 BEFORE Arg1:E34 Arg2:E35 * OVERLAP E35 E36 R139 BEFORE Arg1:E36 Arg2:E41 R140 AFTER Arg1:E41 Arg2:E42 * OVERLAP E42 E44 E45 E46 E47 E48 E51 E52 E53 E54 E56 E75 E76 E90 E91 E92 E80 E93 R141 BEFORE Arg1:E93 Arg2:E81 R142 AFTER Arg1:E81 Arg2:E82 R143 BEFORE Arg1:E82 Arg2:E84 * OVERLAP E84 E85 E83 T179 Duration 4411 4419 8 months E94 Duration:T179 R144 BEFORE Arg1:E83 Arg2:E94 * OVERLAP E94 E74 E86 E87 E88 E89 T180 History 232 261 consumed alcohol for 30 years #1 AnnotatorNotes T180 continuously?