233 lines (232 with data), 8.4 kB

T1	Age 2 13	41-year-old
T2	Personal_background 14 23	Caucasian
T3	Sex 24 29	woman
T4	Date 101 105	2006
E1	Date:T4 
T5	Therapeutic_procedure 57 77	lung transplantation
E2	Therapeutic_procedure:T5 
T6	History 82 97	cystic fibrosis
T7	Detailed_description 50 56	double
T8	Detailed_description 42 49	primary
R1	MODIFY Arg1:T7 Arg2:E2	
R2	MODIFY Arg1:T8 Arg2:E2	
T9	History 111 153	medical history was otherwise unremarkable
T10	Date 245 258	December 2015
E3	Date:T10 
T11	Therapeutic_procedure 274 291	retransplantation
E4	Therapeutic_procedure:T11 
T12	Disease_disorder 304 330	lung allograft dysfunction
E5	Disease_disorder:T12 
T13	Detailed_description 296 303	chronic
R3	MODIFY Arg1:T13 Arg2:E5	
T14	Date 343 358	month preceding
E6	Date:T14 
T15	Diagnostic_procedure 380 396	sputum specimens
E7	Diagnostic_procedure:T15 
T16	Lab_value 378 379	4
R4	MODIFY Arg1:T16 Arg2:E7	
T17	Lab_value 406 414	negative
R5	MODIFY Arg1:T17 Arg2:E7	
T18	Detailed_description 419 436	acid-fast bacilli
R6	MODIFY Arg1:T18 Arg2:T17	
T19	Detailed_description 441 473	specific M. tuberculosis culture
R7	MODIFY Arg1:T19 Arg2:T17	
T20	Diagnostic_procedure 488 513	polymerase chain reaction
E8	Diagnostic_procedure:T20 
T21	Diagnostic_procedure 515 518	PCR
E9	Diagnostic_procedure:T21 
R8	IDENTICAL Arg1:E9 Arg2:E8	
R9	MODIFY Arg1:T17 Arg2:E8	
T22	Date 546 552	day 42
E10	Date:T22 
T23	Diagnostic_procedure 575 593	respiratory status
E11	Diagnostic_procedure:T23 
T24	Lab_value 554 567	deterioration
R10	MODIFY Arg1:T24 Arg2:E11	
T25	Diagnostic_procedure 611 634	computerized tomography
E12	Diagnostic_procedure:T25 
T26	Diagnostic_procedure 636 638	CT
E13	Diagnostic_procedure:T26 
R11	IDENTICAL Arg1:E13 Arg2:E12	
T27	Biological_structure 605 610	chest
R12	MODIFY Arg1:T27 Arg2:E12	
T28	Sign_symptom 680 687	nodules
E14	Sign_symptom:T28 
T29	Detailed_description 670 679	bilateral
T30	Detailed_description 655 669	sub-centimeter
R13	MODIFY Arg1:T29 Arg2:E14	
R14	MODIFY Arg1:T30 Arg2:E14	
T31	Biological_structure 713 735	apical posterior lobes
R15	MODIFY Arg1:T31 Arg2:E14	
T32	Disease_disorder 752 768	pleural effusion
E15	Disease_disorder:T32 
T33	Detailed_description 742 751	bilateral
R16	MODIFY Arg1:T33 Arg2:E15	
T34	Diagnostic_procedure 794 816	bronchoalveolar lavage
E16	Diagnostic_procedure:T34 
T35	Diagnostic_procedure 818 821	BAL
E17	Diagnostic_procedure:T35 
R17	BEFORE Arg1:E17 Arg2:E16	
T36	Detailed_description 478 487	real-time
R18	MODIFY Arg1:T36 Arg2:E8	
T37	Diagnostic_procedure 852 855	PCR
E18	Diagnostic_procedure:T37 
T38	Detailed_description 842 851	real-time
R19	MODIFY Arg1:T38 Arg2:E18	
T39	Lab_value 833 841	positive
R20	MODIFY Arg1:T39 Arg2:E18	
T40	Detailed_description 860 898	rifampicin-susceptible M. tuberculosis
R21	MODIFY Arg1:T40 Arg2:T39	
T41	Diagnostic_procedure 913 920	culture
E19	Diagnostic_procedure:T41 
T42	Lab_value 900 909	confirmed
R22	MODIFY Arg1:T42 Arg2:E19	
T43	Date 938 944	day 62
E20	Date:T43 
T44	Diagnostic_procedure 946 966	Tuberculin skin test
E21	Diagnostic_procedure:T44 
T45	Diagnostic_procedure 968 971	TST
E22	Diagnostic_procedure:T45 
R23	IDENTICAL Arg1:E22 Arg2:E21	
T46	Diagnostic_procedure 1004 1008	IGRA
E23	Diagnostic_procedure:T46 
T47	Diagnostic_procedure 976 1002	interferon-γ release assay
E24	Diagnostic_procedure:T47 
R24	IDENTICAL Arg1:E23 Arg2:E24	
A1	POLARITY E21 NEG
A2	POLARITY E24 NEG
T48	Diagnostic_procedure 1043 1046	BAL
E25	Diagnostic_procedure:T48 
T49	Lab_value 1090 1107	no other pathogen
R25	MODIFY Arg1:T49 Arg2:E25	
T50	Date 1140 1146	day 60
E26	Date:T50 
T51	Coreference 1123 1126	one
E27	Coreference:T51 
R26	IDENTICAL Arg1:E27 Arg2:E25	
T52	Lab_value 1161 1183	Pseudomonas aeruginosa
R27	MODIFY Arg1:T52 Arg2:E27	
T53	Medication 1200 1218	antibiotic therapy
E28	Medication:T53 
T54	Detailed_description 1189 1199	adjunctive
R28	MODIFY Arg1:T54 Arg2:E28	
T55	Medication 1223 1242	imipenem-cilastatin
E29	Medication:T55 
R29	SUB_PROCEDURE Arg1:E29 Arg2:E28	
T56	Dosage 1244 1249	3 g/d
R30	MODIFY Arg1:T56 Arg2:E29	
T57	Diagnostic_procedure 1251 1275	Histological examination
E30	Diagnostic_procedure:T57 
T58	Diagnostic_procedure 1286 1292	biopsy
E31	Diagnostic_procedure:T58 
T59	Biological_structure 1281 1285	lung
R31	MODIFY Arg1:T59 Arg2:E31	
T60	Date 1303 1316	6 weeks after
E32	Date:T60 
T61	Lab_value 1346 1365	caseating granuloma
T62	Lab_value 1370 1378	necrosis
R32	MODIFY Arg1:T61 Arg2:E30	
R33	MODIFY Arg1:T62 Arg2:E30	
T63	Diagnostic_procedure 1469 1472	PCR
E33	Diagnostic_procedure:T63 
T64	Detailed_description 1459 1468	real-time
R34	MODIFY Arg1:T64 Arg2:E33	
T65	Lab_value 1380 1397	Acid-fast bacilli
R35	MODIFY Arg1:T65 Arg2:E33	
T66	Detailed_description 1417 1455	rifampicin-susceptible M. tuberculosis
R36	MODIFY Arg1:T66 Arg2:T65	
T67	Date 1491 1497	day 65
E34	Date:T67 
T68	Diagnostic_procedure 1513 1519	status
E35	Diagnostic_procedure:T68 
T69	Lab_value 1520 1528	worsened
R37	MODIFY Arg1:T69 Arg2:E35	
T70	Sign_symptom 1541 1550	hypoxemia
E36	Sign_symptom:T70 
T71	Severity 1534 1540	severe
R38	MODIFY Arg1:T71 Arg2:E36	
T72	Disease_disorder 1552 1557	shock
E37	Disease_disorder:T72 
T73	Medication 1584 1598	cathecolamines
E38	Medication:T73 
T74	Disease_disorder 1604 1622	multiorgan failure
E39	Disease_disorder:T74 
T75	Date 1658 1664	day 70
E40	Date:T75 
T76	Medication 1694 1703	isoniazid
E41	Medication:T76 
T77	Medication 1705 1715	rifampicin
E42	Medication:T77 
T78	Medication 1717 1727	ethambutol
E43	Medication:T78 
T79	Medication 1733 1745	pyrazinamide
E44	Medication:T79 
T80	Outcome 1636 1640	died
E45	Outcome:T80 
T81	Diagnostic_procedure 1771 1774	PCR
E46	Diagnostic_procedure:T81 
T82	Detailed_description 1761 1770	real-time
R39	MODIFY Arg1:T82 Arg2:E46	
T83	Detailed_description 1790 1804	explanted lung
R40	MODIFY Arg1:T83 Arg2:E46	
T84	Lab_value 1868 1876	negative
R41	MODIFY Arg1:T84 Arg2:E46	
T85	Detailed_description 1809 1858	BALs performed on postoperative days 1, 7, and 21
R42	MODIFY Arg1:T85 Arg2:E46	
T86	Subject 1882 1893	organ donor
T87	Coreference 1942 1944	He
E47	Coreference:T87 
R43	IDENTICAL Arg1:E47 Arg2:T86	
T88	Detailed_description 1894 1940	died of posttraumatic intracerebral hemorrhage
R44	MODIFY Arg1:T88 Arg2:T86	
T89	Detailed_description 1949 1966	a 47-year-old man
R45	MODIFY Arg1:T89 Arg2:E47	
T90	Detailed_description 1972 2031	no history of lung disease or risk factors for tuberculosis
R46	MODIFY Arg1:T90 Arg2:E47	
T91	Detailed_description 2043 2074	chronic alcohol use and smoking
R47	MODIFY Arg1:T91 Arg2:E47	
T93	Coreference 2469 2474	donor
E49	Coreference:T93 
R48	IDENTICAL Arg1:E49 Arg2:E47	
T94	Detailed_description 2442 2454	Both kidneys
R49	MODIFY Arg1:T94 Arg2:E49	
T95	Detailed_description 2480 2516	transplanted into 2 other recipients
R50	MODIFY Arg1:T95 Arg2:T94	
#2	AnnotatorNotes T86	Note that most of the following section is about the donor, not the patient
T92	Detailed_description 2076 2106	TST results were not available
R51	MODIFY Arg1:T92 Arg2:E47	
T96	Detailed_description 2134 2197	lung CT-scan showed no signs of active or previous tuberculosis
R52	MODIFY Arg1:T96 Arg2:E47	
T97	Detailed_description 2202 2244	no TST or IGRA test results were available
R53	MODIFY Arg1:T97 Arg2:E47	
T98	Detailed_description 2254 2328	cultures of per-transplantation right lung biopsy yielded Candida albicans
R54	MODIFY Arg1:T98 Arg2:E47	
T99	Detailed_description 2344 2440	M. tuberculosis real-time PCR yielded negative results on the left and right donor-lung biopsies
R55	MODIFY Arg1:T99 Arg2:T86	
T100	Subject 2567 2584	kidney recipients
T101	Detailed_description 2552 2559;2585 2654	neither had developed any signs or symptoms suggestive of active tuberculosis
R56	MODIFY Arg1:T101 Arg2:T100	
T102	Detailed_description 2518 2550	Six months after transplantation
R57	MODIFY Arg1:T102 Arg2:T101	
*	OVERLAP E2 E1
R58	BEFORE Arg1:E1 Arg2:E3	
*	OVERLAP E3 E4 E5
R59	AFTER Arg1:E5 Arg2:E6	
*	OVERLAP E6 E7 E8
R60	BEFORE Arg1:E8 Arg2:E10	
*	OVERLAP E10 E11 E12 E14 E15 E16 E18
R61	BEFORE Arg1:E18 Arg2:E19	
*	OVERLAP E19 E20 E21 E24
R62	AFTER Arg1:E24 Arg2:E25	
*	OVERLAP E25 E27 E26
R63	BEFORE Arg1:E26 Arg2:E28	
R64	AFTER Arg1:E28 Arg2:E30	
*	OVERLAP E30 E31 E32 E33
R65	BEFORE Arg1:E33 Arg2:E34	
*	OVERLAP E34 E35 E36 E37 E38 E39
T103	Dosage 1574 1583	high dose
R66	MODIFY Arg1:T103 Arg2:E38	
R67	BEFORE Arg1:E39 Arg2:E45	
*	OVERLAP E45 E40 E41 E42 E43 E44
R68	BEFORE Arg1:E44 Arg2:E46	
T104	History 174 240	no known history of pulmonary tuberculosis or tuberculosis contact