--- a
+++ b/processing/MACCROBAT/28321073.ann
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+T1	Age 2 13	65-year-old
+T2	Sex 14 17	man
+T3	Activity 44 61	cigarette smoking
+E1	Activity:T3 
+T4	History 25 61	45-year history of cigarette smoking
+T5	Clinical_event 62 69	visited
+E2	Clinical_event:T5 
+T6	Nonbiological_location 74 82	hospital
+R1	MODIFY Arg1:T6 Arg2:E2	
+T7	Sign_symptom 122 128	shadow
+E3	Sign_symptom:T7 
+T8	Diagnostic_procedure 132 137	X-ray
+E4	Diagnostic_procedure:T8 
+T9	Detailed_description 107 115	abnormal
+T10	Biological_structure 116 121	chest
+R2	MODIFY Arg1:T10 Arg2:E3	
+R3	MODIFY Arg1:T9 Arg2:E3	
+T11	Duration 25 32	45-year
+E5	Duration:T11 
+R4	MODIFY Arg1:E5 Arg2:E1	
+T12	History 142 185	did not have any remarkable medical history
+T13	Medication 214 228	anticoagulants
+E6	Medication:T13 
+A1	POLARITY E6 NEG
+T14	Medication 232 251	antiplatelet agents
+E7	Medication:T14 
+A2	POLARITY E7 NEG
+T15	Diagnostic_procedure 255 274	computed tomography
+E8	Diagnostic_procedure:T15 
+T16	Diagnostic_procedure 276 278	CT
+E9	Diagnostic_procedure:T16 
+R5	IDENTICAL Arg1:E9 Arg2:E8	
+T17	Sign_symptom 301 305	mass
+E10	Sign_symptom:T17 
+T18	Detailed_description 296 300	huge
+R6	MODIFY Arg1:T18 Arg2:E10	
+T19	Biological_structure 313 328	left upper lobe
+R7	MODIFY Arg1:T19 Arg2:E10	
+T20	Distance 344 351	11.0 cm
+R8	MODIFY Arg1:T20 Arg2:E10	
+T21	Biological_structure 399 409	left hilum
+T22	Biological_structure 414 425	mediastinum
+R9	MODIFY Arg1:T21 Arg2:E10	
+R10	MODIFY Arg1:T22 Arg2:E10	
+T23	Sign_symptom 456 466	metastasis
+E11	Sign_symptom:T23 
+T24	Biological_structure 441 455	intrapulmonary
+R11	MODIFY Arg1:T24 Arg2:E11	
+T25	Biological_structure 482 497	left lower lobe
+R12	MODIFY Arg1:T25 Arg2:E11	
+T26	Disease_disorder 499 515	pleural effusion
+E12	Disease_disorder:T26 
+T27	Detailed_description 523 532	left side
+R13	MODIFY Arg1:T27 Arg2:E12	
+T28	Sign_symptom 553 559	tumors
+E13	Sign_symptom:T28 
+T29	Biological_structure 547 552	liver
+R14	MODIFY Arg1:T29 Arg2:E13	
+T30	Detailed_description 538 546	multiple
+R15	MODIFY Arg1:T30 Arg2:E13	
+T31	Distance 573 586	0.5 to 4.7 cm
+R16	MODIFY Arg1:T31 Arg2:E13	
+T32	Coreference 635 645	metastases
+E14	Coreference:T32 
+R17	IDENTICAL Arg1:E14 Arg2:E13	
+T33	Biological_structure 629 634	liver
+R18	MODIFY Arg1:T33 Arg2:E14	
+T34	Detailed_description 651 672	located subcapsularly
+R19	MODIFY Arg1:T34 Arg2:E14	
+T35	Detailed_description 617 621	some
+R20	MODIFY Arg1:T35 Arg2:E14	
+T36	Sign_symptom 712 721	distorted
+E15	Sign_symptom:T36 
+T37	Biological_structure 682 695	liver surface
+R21	MODIFY Arg1:T37 Arg2:E15	
+T38	Detailed_description 700 711	irregularly
+R22	MODIFY Arg1:T38 Arg2:E15	
+T39	Diagnostic_procedure 727 746	laboratory findings
+E16	Diagnostic_procedure:T39 
+T40	Diagnostic_procedure 764 786	white blood cell count
+E17	Diagnostic_procedure:T40 
+T41	Diagnostic_procedure 799 809	hemoglobin
+E18	Diagnostic_procedure:T41 
+T42	Diagnostic_procedure 821 835	platelet count
+E19	Diagnostic_procedure:T42 
+T43	Diagnostic_procedure 849 871	aspartate transaminase
+E20	Diagnostic_procedure:T43 
+T44	Diagnostic_procedure 881 901	alanine transaminase
+E21	Diagnostic_procedure:T44 
+T45	Diagnostic_procedure 915 936	lactate dehydrogenase
+E22	Diagnostic_procedure:T45 
+T46	Diagnostic_procedure 938 941	LDH
+E23	Diagnostic_procedure:T46 
+R23	IDENTICAL Arg1:E23 Arg2:E22	
+T47	Lab_value 787 797	11,900/mm3
+T48	Lab_value 810 819	14.8 g/dL
+T49	Lab_value 836 847	214,000/mm3
+T50	Lab_value 872 879	31 IU/L
+T51	Lab_value 902 909	19 IU/L
+T52	Lab_value 943 951	749 IU/L
+R24	MODIFY Arg1:T47 Arg2:E17	
+R25	MODIFY Arg1:T48 Arg2:E18	
+R26	MODIFY Arg1:T49 Arg2:E19	
+R27	MODIFY Arg1:T50 Arg2:E20	
+R28	MODIFY Arg1:T51 Arg2:E21	
+R29	MODIFY Arg1:T52 Arg2:E22	
+R30	SUB_PROCEDURE Arg1:E17 Arg2:E16	
+R31	SUB_PROCEDURE Arg1:E18 Arg2:E16	
+R32	SUB_PROCEDURE Arg1:E19 Arg2:E16	
+R33	SUB_PROCEDURE Arg1:E20 Arg2:E16	
+R34	SUB_PROCEDURE Arg1:E21 Arg2:E16	
+R35	SUB_PROCEDURE Arg1:E22 Arg2:E16	
+T53	Sign_symptom 956 981	coagulation abnormalities
+E24	Sign_symptom:T53 
+A3	POLARITY E24 NEG
+T54	Diagnostic_procedure 1007 1031	histological examination
+E25	Diagnostic_procedure:T54 
+T55	Diagnostic_procedure 1064 1076	bronchoscopy
+E26	Diagnostic_procedure:T55 
+T56	Disease_disorder 1104 1124	small cell carcinoma
+E27	Disease_disorder:T56 
+T57	Sign_symptom 1037 1042	tumor
+E28	Sign_symptom:T57 
+R36	MODIFY Arg1:E28 Arg2:E25	
+T58	Medication 1246 1258	chemotherapy
+E29	Medication:T58 
+T59	Detailed_description 1236 1245	antitumor
+R37	MODIFY Arg1:T59 Arg2:E29	
+T60	Medication 1273 1282	cisplatin
+E30	Medication:T60 
+T61	Dosage 1284 1310	60 mg/m2 body surface area
+T62	Date 1314 1319	Day 1
+E31	Date:T62 
+T63	Medication 1325 1334	etoposide
+E32	Medication:T63 
+T64	Dosage 1336 1363	100 mg/m2 body surface area
+T65	Date 1367 1375	Days 1-3
+E33	Date:T65 
+R38	MODIFY Arg1:T64 Arg2:E32	
+R39	MODIFY Arg1:T61 Arg2:E30	
+R40	SUB_PROCEDURE Arg1:E30 Arg2:E29	
+R41	SUB_PROCEDURE Arg1:E32 Arg2:E29	
+T66	Date 1381 1400	a day after 2 weeks
+E34	Date:T66 
+T67	Diagnostic_procedure 1418 1420	CT
+E35	Diagnostic_procedure:T67 
+T68	Medication 1448 1460	chemotherapy
+E36	Medication:T68 
+T69	Date 1473 1478	Day 3
+E37	Date:T69 
+T70	Sign_symptom 1537 1547	discomfort
+E38	Sign_symptom:T70 
+T71	Biological_structure 1527 1536	abdominal
+R42	MODIFY Arg1:T71 Arg2:E38	
+T72	Diagnostic_procedure 1557 1568	vital signs
+E39	Diagnostic_procedure:T72 
+T73	Sign_symptom 1576 1587	tachycardia
+E40	Sign_symptom:T73 
+T74	Lab_value 1589 1609	120 beats per minute
+R43	MODIFY Arg1:T74 Arg2:E39	
+#1	AnnotatorNotes T74	implicit heart rate measurement
+T75	Sign_symptom 1615 1626	hypotension
+E41	Sign_symptom:T75 
+T76	Lab_value 1628 1638	85/55 mmHg
+R44	MODIFY Arg1:T76 Arg2:E39	
+#2	AnnotatorNotes T76	implicit blood pressure measurement
+T77	Diagnostic_procedure 1643 1668	hematological examination
+E42	Diagnostic_procedure:T77 
+T78	Sign_symptom 1683 1689	anemia
+E43	Sign_symptom:T78 
+T79	Severity 1676 1682	severe
+R45	MODIFY Arg1:T79 Arg2:E43	
+T80	Diagnostic_procedure 1691 1701	hemoglobin
+E44	Diagnostic_procedure:T80 
+R46	SUB_PROCEDURE Arg1:E44 Arg2:E42	
+T81	Lab_value 1702 1710	6.7 g/dL
+R47	MODIFY Arg1:T81 Arg2:E44	
+T82	Lab_value 1734 1741	dropped
+T83	Duration 1757 1769	over 10 days
+E45	Duration:T83 
+T84	Lab_value 1747 1756	14.8 g/dL
+R48	MODIFY Arg1:T82 Arg2:E44	
+R49	MODIFY Arg1:T84 Arg2:E44	
+T85	Diagnostic_procedure 1834 1843	endoscopy
+E46	Diagnostic_procedure:T85 
+T86	Biological_structure 1817 1833	gastrointestinal
+R50	MODIFY Arg1:T86 Arg2:E46	
+T87	Diagnostic_procedure 1864 1866	CT
+E47	Diagnostic_procedure:T87 
+T88	Sign_symptom 1891 1902	enlargement
+E48	Sign_symptom:T88 
+T89	Detailed_description 1885 1890	rapid
+R51	MODIFY Arg1:T89 Arg2:E48	
+T90	Sign_symptom 1914 1919	tumor
+E49	Sign_symptom:T90 
+T91	Biological_structure 1908 1913	liver
+R52	MODIFY Arg1:T91 Arg2:E49	
+R53	MODIFY Arg1:E49 Arg2:E48	
+T92	Biological_structure 1927 1936	left lobe
+R54	MODIFY Arg1:T92 Arg2:E49	
+T93	Sign_symptom 1962 1980	high-density areas
+E50	Sign_symptom:T93 
+T94	Detailed_description 1954 1961	partial
+R55	MODIFY Arg1:T94 Arg2:E50	
+T95	Diagnostic_procedure 1988 1998	plain scan
+E51	Diagnostic_procedure:T95 
+R56	SUB_PROCEDURE Arg1:E51 Arg2:E47	
+T96	Sign_symptom 2028 2035	ascites
+E52	Sign_symptom:T96 
+T97	Detailed_description 2044 2069	higher density than usual
+R57	MODIFY Arg1:T97 Arg2:E52	
+T98	Sign_symptom 2103 2113	metastasis
+E53	Sign_symptom:T98 
+A4	POLARITY E53 UNCERTAIN
+T99	Biological_structure 2097 2102	liver
+T100	Detailed_description 2088 2096	ruptured
+R58	MODIFY Arg1:T100 Arg2:E53	
+R59	MODIFY Arg1:T99 Arg2:E53	
+T101	Sign_symptom 2141 2148	ascites
+E54	Sign_symptom:T101 
+T102	Detailed_description 2129 2140	hemorrhagic
+R60	MODIFY Arg1:T102 Arg2:E54	
+R61	CAUSE Arg1:E53 Arg2:E54	
+T103	Diagnostic_procedure 2189 2191	CT
+E55	Diagnostic_procedure:T103 
+T104	Detailed_description 2171 2188	contrast-enhanced
+R62	MODIFY Arg1:T104 Arg2:E55	
+T105	Sign_symptom 2215 2228	extravasation
+E56	Sign_symptom:T105 
+A5	POLARITY E56 NEG
+T106	Diagnostic_procedure 2243 2254	angiography
+E57	Diagnostic_procedure:T106 
+T107	Biological_structure 2263 2294	left and right hepatic arteries
+R63	MODIFY Arg1:T107 Arg2:E57	
+T108	Sign_symptom 2372 2385	extravasation
+E58	Sign_symptom:T108 
+A6	POLARITY E58 NEG
+T109	Sign_symptom 2325 2338	tumor vessels
+E59	Sign_symptom:T109 
+T110	Detailed_description 2317 2324	obscure
+R64	MODIFY Arg1:T110 Arg2:E59	
+T111	Biological_structure 2346 2363	left hepatic lobe
+R65	MODIFY Arg1:T111 Arg2:E59	
+T112	Therapeutic_procedure 2646 2681	transcatheter arterial embolization
+E60	Therapeutic_procedure:T112 
+T113	Therapeutic_procedure 2683 2686	TAE
+E61	Therapeutic_procedure:T113 
+R66	IDENTICAL Arg1:E61 Arg2:E60	
+T114	Biological_structure 2695 2719	left main hepatic artery
+R67	MODIFY Arg1:T114 Arg2:E61	
+T115	Therapeutic_procedure 2726 2743	gelform particles
+E62	Therapeutic_procedure:T115 
+R68	SUB_PROCEDURE Arg1:E62 Arg2:E60	
+T116	Diagnostic_procedure 2793 2804	angiography
+E63	Diagnostic_procedure:T116 
+T117	Diagnostic_procedure 2823 2833	blood flow
+E64	Diagnostic_procedure:T117 
+T118	Lab_value 2816 2822	slowed
+R69	MODIFY Arg1:T118 Arg2:E64	
+T119	Biological_structure 2841 2860	left hepatic artery
+R70	MODIFY Arg1:T119 Arg2:E64	
+T120	Therapeutic_procedure 2962 2982	supportive therapies
+E65	Therapeutic_procedure:T120 
+T121	Medication 2994 2997	RBC
+E66	Medication:T121 
+T122	Administration 2998 3010	transfusions
+R71	MODIFY Arg1:T122 Arg2:E66	
+T123	Dosage 3014 3017	6 U
+R72	MODIFY Arg1:T123 Arg2:E66	
+#3	AnnotatorNotes E66	red blood cells
+T124	Diagnostic_procedure 3032 3047	clinical course
+E67	Diagnostic_procedure:T124 
+T125	Lab_value 3063 3073	stabilized
+R73	MODIFY Arg1:T125 Arg2:E67	
+T126	Diagnostic_procedure 3079 3093	blood pressure
+E68	Diagnostic_procedure:T126 
+T127	Lab_value 3110 3121	120/70 mmHg
+R74	MODIFY Arg1:T127 Arg2:E68	
+T128	Sign_symptom 3123 3134	tachycardia
+E69	Sign_symptom:T128 
+A7	POLARITY E69 NEG
+T129	Sign_symptom 3156 3162	anemia
+E70	Sign_symptom:T129 
+A8	TREND E70 DEC
+T130	Sign_symptom 3228 3239	dysfunction
+E71	Sign_symptom:T130 
+A9	POLARITY E71 NEG
+T131	Biological_structure 3222 3227	Liver
+R75	MODIFY Arg1:T131 Arg2:E71	
+T132	Date 3256 3269	A month after
+E72	Date:T132 
+T133	Diagnostic_procedure 3314 3320	health
+E73	Diagnostic_procedure:T133 
+T134	Lab_value 3298 3313	relatively good
+R76	MODIFY Arg1:T134 Arg2:E73	
+T135	Medication 3350 3362	chemotherapy
+E74	Medication:T135 
+T136	Detailed_description 3340 3349	antitumor
+R77	MODIFY Arg1:T136 Arg2:E74	
+T137	Dosage 3408 3419	six courses
+R78	MODIFY Arg1:T137 Arg2:E74	
+T138	Diagnostic_procedure 3436 3444	response
+E75	Diagnostic_procedure:T138 
+T139	Lab_value 3423 3427	good
+T140	Lab_value 3428 3435	partial
+R79	MODIFY Arg1:T140 Arg2:E75	
+R80	MODIFY Arg1:T139 Arg2:E75	
+T141	Medication 3462 3474	chemotherapy
+E76	Medication:T141 
+T142	Sign_symptom 3503 3510	lesions
+E77	Sign_symptom:T142 
+T143	Biological_structure 3488 3492	lung
+T144	Biological_structure 3497 3502	liver
+R81	MODIFY Arg1:T144 Arg2:E77	
+R82	MODIFY Arg1:T143 Arg2:E77	
+R83	BEFORE Arg1:E1 Arg2:E2	
+R84	AFTER Arg1:E2 Arg2:E3	
+*	OVERLAP E3 E4
+R85	AFTER Arg1:E4 Arg2:E6	
+*	OVERLAP E6 E7
+R86	BEFORE Arg1:E7 Arg2:E8	
+*	OVERLAP E8 E10 E11 E12 E13 E14 E15 E16 E24 E25 E26 E27
+R87	BEFORE Arg1:E27 Arg2:E29	
+R88	BEFORE Arg1:E29 Arg2:E34	
+R89	MODIFY Arg1:E31 Arg2:E30	
+R90	MODIFY Arg1:E33 Arg2:E32	
+R91	AFTER Arg1:E34 Arg2:E35	
+R92	BEFORE Arg1:E35 Arg2:E36	
+R93	BEFORE Arg1:E36 Arg2:E37	
+*	OVERLAP E37 E38 E39 E42 E46 E47 E48 E49 E50 E52 E53 E54 E55 E56
+R94	BEFORE Arg1:E56 Arg2:E57	
+*	OVERLAP E57 E59 E58
+R95	BEFORE Arg1:E58 Arg2:E60	
+R96	BEFORE Arg1:E60 Arg2:E63	
+*	OVERLAP E63 E64
+R97	BEFORE Arg1:E64 Arg2:E65	
+*	OVERLAP E65 E66 E67 E68 E69 E70 E71
+R98	BEFORE Arg1:E71 Arg2:E72	
+*	OVERLAP E72 E73 E74 E75 E76 E77
+R99	MODIFY Arg1:E77 Arg2:E75