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T1 Age 3 14 84-year-old T2 Sex 15 20 woman T3 Sign_symptom 54 61 dyspnea E1 Sign_symptom:T3 T4 Nonbiological_location 36 48 local clinic T5 Clinical_event 21 30 presented E2 Clinical_event:T5 R1 MODIFY Arg1:T4 Arg2:E2 T6 Sign_symptom 88 92 pain E3 Sign_symptom:T6 T7 Biological_structure 78 87 left back R2 MODIFY Arg1:T7 Arg2:E3 T8 Detailed_description 62 73 on exertion R3 MODIFY Arg1:T8 Arg2:E1 T9 Duration 93 114 persisting for a mont E4 Duration:T9 T10 Clinical_event 125 133 admitted E5 Clinical_event:T10 T11 Nonbiological_location 141 149 hospital R4 MODIFY Arg1:T11 Arg2:E5 T12 Sign_symptom 166 182 pleural effusion E6 Sign_symptom:T12 T13 Detailed_description 161 165 left R5 MODIFY Arg1:T13 Arg2:E6 T14 Diagnostic_procedure 194 199 X-ray E7 Diagnostic_procedure:T14 T15 Biological_structure 188 193 chest R6 MODIFY Arg1:T15 Arg2:E7 T16 History 214 226 hypertension T17 History 252 307 no history of pleural tuberculosis or chronic pyothorax T18 Diagnostic_procedure 352 363 examination E8 Diagnostic_procedure:T18 T19 Diagnostic_procedure 369 380 vital signs E9 Diagnostic_procedure:T19 T20 Diagnostic_procedure 385 402 oxygen saturation E10 Diagnostic_procedure:T20 T21 Lab_value 408 414 normal R7 MODIFY Arg1:T21 Arg2:E10 R8 MODIFY Arg1:T21 Arg2:E9 T22 Diagnostic_procedure 416 420 SpO2 E11 Diagnostic_procedure:T22 T23 Lab_value 422 425 96% R9 MODIFY Arg1:T23 Arg2:E11 T24 Detailed_description 426 437 ambient air R10 MODIFY Arg1:T24 Arg2:E11 T25 Diagnostic_procedure 442 459 chest examination E12 Diagnostic_procedure:T25 T26 Sign_symptom 471 475 mass E13 Sign_symptom:T26 T27 Sign_symptom 510 514 pain E14 Sign_symptom:T27 T28 Biological_structure 483 504 left side of her back R11 MODIFY Arg1:T28 Arg2:E14 T29 Sign_symptom 519 545 decreased breathing sounds E15 Sign_symptom:T29 T30 Biological_structure 553 574 left lower-lung field R12 MODIFY Arg1:T30 Arg2:E15 T31 Diagnostic_procedure 592 612 examination findings E16 Diagnostic_procedure:T31 T32 Detailed_description 576 584 The rest R13 MODIFY Arg1:T32 Arg2:E16 T33 Lab_value 618 624 normal R14 MODIFY Arg1:T33 Arg2:E16 T34 Diagnostic_procedure 626 642 Laboratory tests E17 Diagnostic_procedure:T34 T35 Diagnostic_procedure 671 689 C reactive protein E18 Diagnostic_procedure:T35 T36 Lab_value 652 667 elevated levels R15 MODIFY Arg1:T36 Arg2:E18 T37 Diagnostic_procedure 691 712 lactate dehydrogenase E19 Diagnostic_procedure:T37 T38 Diagnostic_procedure 714 717 LDH E20 Diagnostic_procedure:T38 R16 IDENTICAL Arg1:E20 Arg2:E19 R17 MODIFY Arg1:T36 Arg2:E19 T39 Diagnostic_procedure 724 754 soluble interleukin-2 receptor E21 Diagnostic_procedure:T39 T40 Diagnostic_procedure 756 762 sIL-2R E22 Diagnostic_procedure:T40 R18 IDENTICAL Arg1:E22 Arg2:E21 R19 MODIFY Arg1:T36 Arg2:E21 T41 Diagnostic_procedure 783 788 X-ray E23 Diagnostic_procedure:T41 T42 Biological_structure 777 782 chest R20 MODIFY Arg1:T42 Arg2:E23 T43 Sign_symptom 809 825 pleural effusion E24 Sign_symptom:T43 T44 Detailed_description 804 808 left R21 MODIFY Arg1:T44 Arg2:E24 T45 Detailed_description 831 848 mediastinal shift R22 MODIFY Arg1:T45 Arg2:E24 T46 Date 850 875 On the first hospital day E25 Date:T46 T47 Biological_structure 880 891 intercostal T48 Therapeutic_procedure 892 905 drainage tube E26 Therapeutic_procedure:T48 R23 MODIFY Arg1:T47 Arg2:E26 T49 Diagnostic_procedure 946 965 computed tomography E27 Diagnostic_procedure:T49 T50 Diagnostic_procedure 967 969 CT E28 Diagnostic_procedure:T50 R24 IDENTICAL Arg1:E28 Arg2:E27 T51 Biological_structure 940 945 chest R25 MODIFY Arg1:T51 Arg2:E27 T52 Sign_symptom 1009 1013 mass E29 Sign_symptom:T52 T53 Biological_structure 1001 1008 pleural T54 Detailed_description 991 1000 irregular R26 MODIFY Arg1:T53 Arg2:E29 R27 MODIFY Arg1:T54 Arg2:E29 T55 Biological_structure 1027 1042 left chest wall R28 MODIFY Arg1:T55 Arg2:E29 T56 Sign_symptom 1052 1063 destruction E30 Sign_symptom:T56 T57 Biological_structure 1048 1051 rib R29 MODIFY Arg1:T57 Arg2:E30 T58 Sign_symptom 1068 1084 pleural effusion E31 Sign_symptom:T58 T59 Sign_symptom 1090 1094 mass E32 Sign_symptom:T59 T60 Biological_structure 1099 1136 adjacent to the posterior mediastinum R30 MODIFY Arg1:T60 Arg2:E32 T61 Sign_symptom 1296 1304 purulent E33 Sign_symptom:T61 A1 POLARITY E33 NEG T63 Biological_structure 1263 1276 pleural fluid R31 MODIFY Arg1:T63 Arg2:E33 T62 Sign_symptom 1281 1287 serous E34 Sign_symptom:T62 R32 MODIFY Arg1:T63 Arg2:E34 T64 Sign_symptom 1166 1170 mass E35 Sign_symptom:T64 R33 IDENTICAL Arg1:E35 Arg2:E32 T65 Detailed_description 1146 1158 lateral side T66 Detailed_description 1175 1180 thick T67 Biological_structure 1198 1208 chest wall R34 MODIFY Arg1:T65 Arg2:E35 R35 MODIFY Arg1:T66 Arg2:E35 R36 MODIFY Arg1:T67 Arg2:E35 T68 Disease_disorder 1241 1257 chest wall tumor E36 Disease_disorder:T68 T69 Sign_symptom 1231 1235 mass E37 Sign_symptom:T69 R37 IDENTICAL Arg1:E37 Arg2:E35 T70 Diagnostic_procedure 1308 1322 fluid analysis E38 Diagnostic_procedure:T70 T71 Lab_value 1339 1348 exudative R38 MODIFY Arg1:T71 Arg2:E38 T72 Lab_value 1354 1399 81% of the white blood cells were lymphocytes R39 MODIFY Arg1:T72 Arg2:E38 T73 Diagnostic_procedure 1405 1418 fluid culture E39 Diagnostic_procedure:T73 T74 Lab_value 1423 1431 negative R40 MODIFY Arg1:T74 Arg2:E39 T75 Diagnostic_procedure 1437 1445 cytology E40 Diagnostic_procedure:T75 T76 Sign_symptom 1475 1485 malignancy E41 Sign_symptom:T76 A2 POLARITY E41 NEG R41 MODIFY Arg1:E41 Arg2:E40 T77 Diagnostic_procedure 1514 1520 biopsy E42 Diagnostic_procedure:T77 T78 Detailed_description 1507 1513 needle R42 MODIFY Arg1:T78 Arg2:E42 T79 Detailed_description 1497 1506 CT-guided R43 MODIFY Arg1:T79 Arg2:E42 T80 Diagnostic_procedure 1540 1554 histopathology E43 Diagnostic_procedure:T80 T81 Disease_disorder 1588 1617 diffuse large B-cell lymphoma E44 Disease_disorder:T81 T82 Disease_disorder 1619 1624 DLBCL E45 Disease_disorder:T82 R44 IDENTICAL Arg1:E45 Arg2:E44 T83 Diagnostic_procedure 1648 1652 CD10 E46 Diagnostic_procedure:T83 T84 Diagnostic_procedure 1657 1661 CD20 E47 Diagnostic_procedure:T84 T85 Diagnostic_procedure 1679 1682 CD3 E48 Diagnostic_procedure:T85 T86 Diagnostic_procedure 1687 1690 CD5 E49 Diagnostic_procedure:T86 T87 Lab_value 1635 1643 positive R45 MODIFY Arg1:T87 Arg2:E46 R46 MODIFY Arg1:T87 Arg2:E47 T88 Lab_value 1666 1674 negative R47 MODIFY Arg1:T88 Arg2:E48 R48 MODIFY Arg1:T88 Arg2:E49 T89 Diagnostic_procedure 1700 1770 18-fluorodeoxyglucose positron emission tomography/computed tomography E50 Diagnostic_procedure:T89 T90 Diagnostic_procedure 1772 1782 FDG-PET/CT E51 Diagnostic_procedure:T90 R49 IDENTICAL Arg1:E51 Arg2:E50 T91 Sign_symptom 1793 1808 high FDG uptake E52 Sign_symptom:T91 T92 History 2007 2057 never had either tuberculous pleurisy or pyothorax T93 Diagnostic_procedure 2063 2081 performance status E53 Diagnostic_procedure:T93 T94 Diagnostic_procedure 2083 2085 PS E54 Diagnostic_procedure:T94 R50 IDENTICAL Arg1:E54 Arg2:E53 T95 Lab_value 2091 2092 3 R51 MODIFY Arg1:T95 Arg2:E53 T96 Sign_symptom 1832 1836 mass E55 Sign_symptom:T96 T97 Biological_structure 1816 1831 left chest wall R52 MODIFY Arg1:T97 Arg2:E55 T98 Disease_disorder 1903 1929 primary malignant lymphoma E56 Disease_disorder:T98 T99 Biological_structure 1930 1961 originating from the chest wall R53 MODIFY Arg1:T99 Arg2:E56 T100 Sign_symptom 2122 2129 fatigue E57 Sign_symptom:T100 #1 AnnotatorNotes T95 Capable of only limited selfcare; confined to bed or chair more than 50% of waking hours T101 Sign_symptom 2113 2117 pain E58 Sign_symptom:T101 T102 Biological_structure 2108 2112 back R54 MODIFY Arg1:T102 Arg2:E58 T103 Medication 2273 2282 etoposide E59 Medication:T103 T104 Medication 2245 2254 Rituximab E60 Medication:T104 A3 POLARITY E60 NEG T105 Administration 2268 2272 oral T106 Detailed_description 2259 2267 low-dose R55 MODIFY Arg1:T105 Arg2:E59 R56 MODIFY Arg1:T106 Arg2:E59 T107 Dosage 2284 2304 50 mg/day d1-14, q28 R57 MODIFY Arg1:T107 Arg2:E59 T108 Sign_symptom 2328 2344 pleural effusion E61 Sign_symptom:T108 A4 POLARITY E61 NEG T109 Date 2357 2373 within two weeks E62 Date:T109 T110 Sign_symptom 2384 2388 pain E63 Sign_symptom:T110 A5 POLARITY E63 NEG T111 Biological_structure 2379 2383 back R58 MODIFY Arg1:T111 Arg2:E63 T112 Diagnostic_procedure 2410 2412 PS E64 Diagnostic_procedure:T112 T113 Lab_value 2425 2426 1 R59 MODIFY Arg1:T113 Arg2:E64 T114 Date 2427 2441 within a month E65 Date:T114 T115 Diagnostic_procedure 2443 2451 Chest CT E66 Diagnostic_procedure:T115 T116 Date 2462 2479 four months later E67 Date:T116 T117 Lab_value 2487 2504 complete response R60 MODIFY Arg1:T117 Arg2:E66 T118 Medication 2540 2552 chemotherapy E68 Medication:T118 T119 Administration 2535 2539 oral R61 MODIFY Arg1:T119 Arg2:E68 T120 Diagnostic_procedure 2575 2577 PS E69 Diagnostic_procedure:T120 T121 Lab_value 2570 2574 good R62 MODIFY Arg1:T121 Arg2:E69 T122 Date 2582 2610 one year after the diagnosis E70 Date:T122 * OVERLAP E3 E4 E1 R63 AFTER Arg1:E2 Arg2:E1 R64 BEFORE Arg1:E4 Arg2:E5 * OVERLAP E5 E6 E7 E8 E9 E10 E11 E12 E13 E14 E15 E16 E17 E18 E19 E21 E23 E24 R65 BEFORE Arg1:E24 Arg2:E25 * OVERLAP E25 E26 R66 BEFORE Arg1:E26 Arg2:E27 * OVERLAP E27 E29 E30 E31 E32 E35 E36 E34 E33 E38 E39 E40 E41 R67 BEFORE Arg1:E41 Arg2:E42 * OVERLAP E42 E43 E44 E46 E47 E48 E49 E50 E52 E55 E56 R68 BEFORE Arg1:E56 Arg2:E53 * OVERLAP E53 E58 E57 E60 R69 BEFORE Arg1:E60 Arg2:E59 R70 BEFORE Arg1:E59 Arg2:E61 * OVERLAP E61 E62 E63 R71 BEFORE Arg1:E63 Arg2:E64 * OVERLAP E64 E65 R72 BEFORE Arg1:E65 Arg2:E66 * OVERLAP E66 E67 R73 BEFORE Arg1:E67 Arg2:E68 * OVERLAP E68 E69 E70 T123 History 231 243 dyslipidemia T124 History 309 347 nor a smoking history or dust exposure