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T1 Age 3 14 18-year-old T2 Occupation 15 30 college student T3 Clinical_event 35 43 referred E1 Clinical_event:T3 T4 Diagnostic_procedure 86 96 hemoglobin E2 Diagnostic_procedure:T4 T5 Lab_value 101 109 4.7 g/dl R1 MODIFY Arg1:T5 Arg2:E2 T6 Lab_value 82 85 low R2 MODIFY Arg1:T6 Arg2:E2 T7 Nonbiological_location 44 70 from the University Clinic R3 MODIFY Arg1:T7 Arg2:E1 T8 History 112 134 He was completely well T9 Date 140 154 one month back E3 Date:T9 T10 Sign_symptom 183 195 fatigability E4 Sign_symptom:T10 T11 Sign_symptom 206 215 dizziness E5 Sign_symptom:T11 T12 Sign_symptom 217 228 palpitation E6 Sign_symptom:T12 T13 Sign_symptom 233 240 dyspnea E7 Sign_symptom:T13 T14 Detailed_description 178 182 easy T15 Detailed_description 197 205 postural R4 MODIFY Arg1:T14 Arg2:E4 R5 MODIFY Arg1:T15 Arg2:E5 T16 Sign_symptom 267 278 weight loss E8 Sign_symptom:T16 T17 Lab_value 261 266 30 kg R6 MODIFY Arg1:T17 Arg2:E8 T18 Duration 279 301 over the past 6 months E9 Duration:T18 T19 History 261 301 30 kg weight loss over the past 6 months T20 Diagnostic_procedure 306 326 physical examination E10 Diagnostic_procedure:T20 T21 Sign_symptom 338 342 pale E11 Sign_symptom:T21 T22 Sign_symptom 348 357 jaundiced E12 Sign_symptom:T22 A1 POLARITY E12 NEG T23 Sign_symptom 361 369 cyanosed E13 Sign_symptom:T23 A2 POLARITY E13 NEG T24 Diagnostic_procedure 375 386 vital signs E14 Diagnostic_procedure:T24 T25 Lab_value 396 416 within normal limits R7 MODIFY Arg1:T25 Arg2:E14 T26 Diagnostic_procedure 441 451 heart rate E15 Diagnostic_procedure:T26 T27 Lab_value 432 440 elevated T28 Lab_value 453 459 98/min R8 MODIFY Arg1:T27 Arg2:E15 R9 MODIFY Arg1:T28 Arg2:E15 T29 Diagnostic_procedure 504 516 examinations E16 Diagnostic_procedure:T29 T30 Biological_structure 494 503 abdominal T31 Biological_structure 478 489 respiratory T32 Biological_structure 462 476 Cardiovascular R10 MODIFY Arg1:T30 Arg2:E16 R11 MODIFY Arg1:T31 Arg2:E16 R12 MODIFY Arg1:T32 Arg2:E16 T33 Lab_value 522 534 unremarkable R13 MODIFY Arg1:T33 Arg2:E16 T34 Clinical_event 544 558 investigations E17 Clinical_event:T34 T35 Nonbiological_location 566 574 hospital R14 MODIFY Arg1:T35 Arg2:E17 T36 Diagnostic_procedure 588 598 hemoglobin E18 Diagnostic_procedure:T36 T37 Lab_value 584 587 low R15 MODIFY Arg1:T37 Arg2:E18 T38 Lab_value 606 614 5.1 g/dl R16 MODIFY Arg1:T38 Arg2:E18 T39 Diagnostic_procedure 621 625 iron E19 Diagnostic_procedure:T39 T40 Lab_value 617 620 low R17 MODIFY Arg1:T40 Arg2:E19 T41 Lab_value 627 636 <10 ug/dl R18 MODIFY Arg1:T41 Arg2:E19 T42 Diagnostic_procedure 654 671 occult blood test E20 Diagnostic_procedure:T42 T43 Lab_value 645 653 positive R19 MODIFY Arg1:T43 Arg2:E20 T44 Disease_disorder 700 729 microcytic hypochromic anemia E21 Disease_disorder:T44 A3 POLARITY E21 UNCERTAIN T45 Diagnostic_procedure 759 779 Bone marrow aspirate E22 Diagnostic_procedure:T45 T46 Diagnostic_procedure 784 799 trephine biopsy E23 Diagnostic_procedure:T46 T47 Lab_value 809 829 normocellular marrow R20 MODIFY Arg1:T47 Arg2:E23 R21 MODIFY Arg1:T47 Arg2:E22 T48 Lab_value 841 872 normal trilineage hematopoiesis R22 MODIFY Arg1:T48 Arg2:E23 R23 MODIFY Arg1:T48 Arg2:E22 T49 Diagnostic_procedure 883 892 endoscopy E24 Diagnostic_procedure:T49 T50 Biological_structure 874 882 Upper GI R24 MODIFY Arg1:T50 Arg2:E24 T51 Disease_disorder 915 924 gastritis E25 Disease_disorder:T51 T52 Biological_structure 908 914 antral T53 Detailed_description 900 907 erosive R25 MODIFY Arg1:T52 Arg2:E25 R26 MODIFY Arg1:T53 Arg2:E25 T54 Sign_symptom 948 960 inflammation E26 Sign_symptom:T54 T55 Detailed_description 937 947 ulcerative T56 Detailed_description 930 936 patchy R27 MODIFY Arg1:T55 Arg2:E26 R28 MODIFY Arg1:T56 Arg2:E26 T57 Diagnostic_procedure 972 982 ultrasound E27 Diagnostic_procedure:T57 T58 Biological_structure 962 971 Abdominal R29 MODIFY Arg1:T58 Arg2:E27 T59 Sign_symptom 1001 1009 enlarged E28 Sign_symptom:T59 T60 Biological_structure 1010 1015 liver T61 Severity 992 1000 slightly R30 MODIFY Arg1:T60 Arg2:E28 R31 MODIFY Arg1:T61 Arg2:E28 T62 Sign_symptom 1041 1047 lesion E29 Sign_symptom:T62 T63 Shape 1023 1030 rounded R32 MODIFY Arg1:T63 Arg2:E29 T64 Detailed_description 1031 1040 echogenic R33 MODIFY Arg1:T64 Arg2:E29 T65 Biological_structure 1055 1086 anterior wall of the right lobe R34 MODIFY Arg1:T65 Arg2:E29 T66 Disease_disorder 1101 1111 hemangioma E30 Disease_disorder:T66 A4 POLARITY E30 MAYBE_POS T67 Sign_symptom 1137 1145 enlarged E31 Sign_symptom:T67 T68 Severity 1128 1136 slightly T69 Biological_structure 1117 1123 spleen R35 MODIFY Arg1:T69 Arg2:E31 R36 MODIFY Arg1:T68 Arg2:E31 T70 Lab_value 1150 1172 normal in echogenicity R37 MODIFY Arg1:T70 Arg2:T69 T71 Sign_symptom 1187 1194 lesions E32 Sign_symptom:T71 A5 POLARITY E32 NEG T72 Detailed_description 1181 1186 focal R38 MODIFY Arg1:T72 Arg2:E32 T73 Diagnostic_procedure 1196 1215 Computed Tomography E33 Diagnostic_procedure:T73 T74 Diagnostic_procedure 1217 1219 CT E34 Diagnostic_procedure:T74 R39 IDENTICAL Arg1:E34 Arg2:E33 T75 Biological_structure 1233 1240 abdomen T76 Biological_structure 1245 1251 pelvis R40 MODIFY Arg1:T75 Arg2:E33 R41 MODIFY Arg1:T76 Arg2:E33 T77 Sign_symptom 1299 1303 mass E35 Sign_symptom:T77 T78 Detailed_description 1261 1273 fairly large T79 Detailed_description 1274 1286 well defined T80 Detailed_description 1287 1298 soft tissue R42 MODIFY Arg1:T78 Arg2:E35 R43 MODIFY Arg1:T79 Arg2:E35 R44 MODIFY Arg1:T80 Arg2:E35 T81 Biological_structure 1319 1340 anterior upper pelvis R45 MODIFY Arg1:T81 Arg2:E35 T82 Sign_symptom 1388 1398 thickening E36 Sign_symptom:T82 T83 Biological_structure 1377 1387 bowel wall R46 MODIFY Arg1:T83 Arg2:E36 T84 Biological_structure 1355 1368 jejunal loops R47 MODIFY Arg1:T84 Arg2:E35 R48 CAUSE Arg1:E35 Arg2:E36 T85 Diagnostic_procedure 1437 1447 laparotomy E37 Diagnostic_procedure:T85 T86 Therapeutic_procedure 1452 1460 excision E38 Therapeutic_procedure:T86 T87 Sign_symptom 1476 1480 mass E39 Sign_symptom:T87 T88 Biological_structure 1468 1475 jejunal R49 MODIFY Arg1:T88 Arg2:E39 T89 Diagnostic_procedure 1482 1505 Macroscopic examination E40 Diagnostic_procedure:T89 T90 Volume 1518 1531 11 × 8 × 2 cm T91 Sign_symptom 1540 1544 mass E41 Sign_symptom:T91 R50 MODIFY Arg1:T90 Arg2:E41 T92 Biological_structure 1532 1539 annular R51 MODIFY Arg1:T92 Arg2:E41 T93 Biological_structure 1553 1576 within the jejunal wall R52 MODIFY Arg1:T93 Arg2:E41 T94 Biological_structure 1577 1606 ulcerating through the mucosa T95 Biological_structure 1611 1643 extending to the serosal surface R53 MODIFY Arg1:T94 Arg2:E41 R54 MODIFY Arg1:T95 Arg2:E41 T96 Diagnostic_procedure 1645 1668 Microscopic examination E42 Diagnostic_procedure:T96 T97 Sign_symptom 1680 1685 tumor E43 Sign_symptom:T97 T98 Biological_structure 1702 1720 muscularis propria R55 MODIFY Arg1:T98 Arg2:E43 T99 Biological_structure 1725 1748 extending to the mucosa T100 Biological_structure 1757 1763 serosa R56 MODIFY Arg1:T99 Arg2:E43 R57 MODIFY Arg1:T100 Arg2:E43 T101 Coreference 1769 1785 neoplastic cells E44 Coreference:T101 R58 IDENTICAL Arg1:E44 Arg2:E43 T102 Shape 1803 1839 predominantly pseudoalveolar pattern R59 MODIFY Arg1:T102 Arg2:E44 T103 Coreference 1852 1856 They E45 Coreference:T103 R60 IDENTICAL Arg1:E45 Arg2:E44 T104 Shape 1862 1871 polygonal R61 MODIFY Arg1:T104 Arg2:E45 T105 Detailed_description 1886 1936 variable amount of eosinophilic to clear cytoplasm R62 MODIFY Arg1:T105 Arg2:E45 T106 Detailed_description 1951 2019 nuclei were oval with vesicular chromatin and inconspicuous nucleoli R63 MODIFY Arg1:T106 Arg2:E45 T107 Sign_symptom 2062 2073 giant cells E46 Sign_symptom:T107 T108 Detailed_description 2031 2046 osteoclast-like T109 Detailed_description 2047 2061 multinucleated T110 Detailed_description 2021 2030 Scattered R64 MODIFY Arg1:T109 Arg2:E46 R65 MODIFY Arg1:T108 Arg2:E46 R66 MODIFY Arg1:T110 Arg2:E46 T111 Sign_symptom 2136 2144 necrosis E47 Sign_symptom:T111 T112 Sign_symptom 2116 2131 mitotic figures E48 Sign_symptom:T112 T113 Detailed_description 2107 2115 Frequent R67 MODIFY Arg1:T113 Arg2:E48 T114 Sign_symptom 2182 2199 involved by tumor E49 Sign_symptom:T114 A6 POLARITY E49 NEG T115 Biological_structure 2157 2172 All lymph nodes R68 MODIFY Arg1:T115 Arg2:E49 T116 Diagnostic_procedure 2201 2222 Immunohistochemically E50 Diagnostic_procedure:T116 T117 Diagnostic_procedure 2286 2299 S-100 protein E51 Diagnostic_procedure:T117 T118 Lab_value 2273 2281 positive R69 MODIFY Arg1:T118 Arg2:E51 T119 Coreference 2228 2244 neoplastic cells E52 Coreference:T119 R70 IDENTICAL Arg1:E52 Arg2:E45 T120 Diagnostic_procedure 2338 2346 vimentin E53 Diagnostic_procedure:T120 R71 SUB_PROCEDURE Arg1:E51 Arg2:E50 T121 Lab_value 2325 2333 positive R72 SUB_PROCEDURE Arg1:E53 Arg2:E50 R73 MODIFY Arg1:T121 Arg2:E53 R74 MODIFY Arg1:E52 Arg2:E50 T122 Diagnostic_procedure 2348 2367 Melanocytic markers E54 Diagnostic_procedure:T122 T123 Diagnostic_procedure 2369 2374 HMB45 E55 Diagnostic_procedure:T123 T124 Diagnostic_procedure 2379 2386 Melan A E56 Diagnostic_procedure:T124 R75 SUB_PROCEDURE Arg1:E55 Arg2:E54 R76 SUB_PROCEDURE Arg1:E56 Arg2:E54 T125 Diagnostic_procedure 2389 2411 neuroendocrine markers E57 Diagnostic_procedure:T125 T126 Diagnostic_procedure 2413 2427 chromogranin A E58 Diagnostic_procedure:T126 T127 Diagnostic_procedure 2429 2442 synaptophysin E59 Diagnostic_procedure:T127 T128 Diagnostic_procedure 2447 2451 CD56 E60 Diagnostic_procedure:T128 T129 Diagnostic_procedure 2454 2473 smooth muscle actin E61 Diagnostic_procedure:T129 T130 Diagnostic_procedure 2475 2481 desmin E62 Diagnostic_procedure:T130 T131 Diagnostic_procedure 2483 2487 CD34 E63 Diagnostic_procedure:T131 T132 Diagnostic_procedure 2489 2494 CD117 E64 Diagnostic_procedure:T132 T133 Diagnostic_procedure 2496 2507 cytokeratin E65 Diagnostic_procedure:T133 T134 Diagnostic_procedure 2512 2515 LCA E66 Diagnostic_procedure:T134 T135 Lab_value 2525 2533 negative T136 Coreference 2541 2557 neoplastic cells E67 Coreference:T136 R77 IDENTICAL Arg1:E67 Arg2:E52 R78 SUB_PROCEDURE Arg1:E58 Arg2:E57 R79 SUB_PROCEDURE Arg1:E59 Arg2:E57 R80 MODIFY Arg1:T135 Arg2:E66 R81 MODIFY Arg1:T135 Arg2:E65 R82 MODIFY Arg1:T135 Arg2:E64 R83 MODIFY Arg1:T135 Arg2:E63 R84 MODIFY Arg1:T135 Arg2:E62 R85 MODIFY Arg1:T135 Arg2:E61 R86 MODIFY Arg1:T135 Arg2:E60 R87 MODIFY Arg1:T135 Arg2:E59 R88 MODIFY Arg1:T135 Arg2:E58 R89 MODIFY Arg1:T135 Arg2:E56 R90 MODIFY Arg1:T135 Arg2:E55 T137 Diagnostic_procedure 2559 2592 Fluorescein in situ hybridization E68 Diagnostic_procedure:T137 T138 Diagnostic_procedure 2594 2598 FISH E69 Diagnostic_procedure:T138 R91 IDENTICAL Arg1:E69 Arg2:E68 T139 Detailed_description 2613 2636 EWSR1 break apart probe T140 Detailed_description 2640 2663 paraffin-embedded tumor R92 MODIFY Arg1:T139 Arg2:E68 R93 MODIFY Arg1:T140 Arg2:E68 T141 Sign_symptom 2685 2704 22q12 rearrangement E70 Sign_symptom:T141 T142 Lab_value 2708 2749 197 out of 205 (96%) of interphase nuclei R94 MODIFY Arg1:T142 Arg2:E70 T143 Medication 3006 3018 chemotherapy E71 Medication:T143 A7 POLARITY E71 NEG T144 Therapeutic_procedure 3022 3034 radiotherapy E72 Therapeutic_procedure:T144 A8 POLARITY E72 NEG T145 Clinical_event 3056 3065 follow up E73 Clinical_event:T145 T146 Sign_symptom 3088 3100 disease free E74 Sign_symptom:T146 T147 Duration 3105 3112 3 years E75 Duration:T147 T148 Clinical_event 3122 3131 presented E76 Clinical_event:T148 T149 Sign_symptom 3143 3153 recurrence E77 Sign_symptom:T149 T150 Detailed_description 3137 3142 local R95 MODIFY Arg1:T150 Arg2:E77 T151 Therapeutic_procedure 3187 3196 resection E78 Therapeutic_procedure:T151 A9 POLARITY E78 NEG T152 Nonbiological_location 3240 3261 different institution T153 Clinical_event 3213 3234 sought medical advice E79 Clinical_event:T153 R96 MODIFY Arg1:T152 Arg2:E79 T154 Outcome 3271 3275 died E80 Outcome:T154 T155 Date 3291 3303 a year later E81 Date:T155 * OVERLAP E1 E2 R97 AFTER Arg1:E2 Arg2:E3 T156 Clinical_event 163 172 presented E82 Clinical_event:T156 * OVERLAP E3 E82 E4 E5 E6 E7 R98 AFTER Arg1:E7 Arg2:E8 * OVERLAP E8 E9 R99 BEFORE Arg1:E9 Arg2:E10 * OVERLAP E10 E11 E12 E13 E14 E15 E16 E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E35 E36 R100 BEFORE Arg1:E36 Arg2:E37 * OVERLAP E37 E38 E39 E40 E41 E42 E43 E46 E48 E47 E49 E50 E54 E57 E60 E61 E62 E63 E64 E65 E66 E68 E70 R101 BEFORE Arg1:E70 Arg2:E71 * OVERLAP E71 E72 R102 BEFORE Arg1:E72 Arg2:E73 * OVERLAP E73 E74 E75 R103 BEFORE Arg1:E75 Arg2:E76 * OVERLAP E76 E77 E78 R104 BEFORE Arg1:E78 Arg2:E79 * OVERLAP E79 E80 E81