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T1 Age 2 13 64-year-old T2 Sex 14 17 man T3 Clinical_event 22 30 admitted E1 Clinical_event:T3 T4 Nonbiological_location 38 68 Department of Gastroenterology T5 Nonbiological_location 76 150 Affiliated Hospital of Qingdao University Medical College (Qingdao, China) R1 MODIFY Arg1:T4 Arg2:T5 R2 MODIFY Arg1:T5 Arg2:E1 T6 Sign_symptom 169 174 pains E2 Sign_symptom:T6 T7 Biological_structure 158 168 epigastric R3 MODIFY Arg1:T7 Arg2:E2 T8 Diagnostic_procedure 176 196 Physical examination E3 Diagnostic_procedure:T8 T9 Sign_symptom 218 222 mass E4 Sign_symptom:T9 A1 POLARITY E4 NEG T10 Sign_symptom 224 239 lymphadenopathy E5 Sign_symptom:T10 A2 POLARITY E5 NEG T11 Sign_symptom 244 256 organomegaly E6 Sign_symptom:T11 A3 POLARITY E6 NEG T12 Diagnostic_procedure 261 270 endoscopy E7 Diagnostic_procedure:T12 T13 Sign_symptom 291 298 lesions E8 Sign_symptom:T13 T14 Detailed_description 272 279 several T15 Biological_structure 280 290 submucosal R4 MODIFY Arg1:T15 Arg2:E8 R5 MODIFY Arg1:T14 Arg2:E8 T16 Biological_structure 322 336 gastric antrum T17 Biological_structure 345 358 duodenal bulb R6 MODIFY Arg1:T16 Arg2:E8 R7 MODIFY Arg1:T17 Arg2:E8 T18 Diagnostic_procedure 368 394 Endoscopic ultrasonography E9 Diagnostic_procedure:T18 T19 Diagnostic_procedure 396 399 EUS E10 Diagnostic_procedure:T19 R8 IDENTICAL Arg1:E10 Arg2:E9 T20 Detailed_description 402 420 OLYMPUS EUS EU-ME2 T21 Detailed_description 422 442 Miniprobe sonography R9 MODIFY Arg1:T20 Arg2:E9 R10 MODIFY Arg1:T21 Arg2:E9 T22 Sign_symptom 466 473 lesions E11 Sign_symptom:T22 T23 Distance 479 492 almost 0.5-cm T24 Detailed_description 507 517 hypoechoic T25 Sign_symptom 518 527 neoplasms E12 Sign_symptom:T25 R11 MODIFY Arg1:T24 Arg2:E12 R12 MODIFY Arg1:T23 Arg2:E12 T26 Biological_structure 549 564 submucous layer R13 MODIFY Arg1:T26 Arg2:E12 T27 Disease_disorder 613 634 neuroendocrine tumors E13 Disease_disorder:T27 T28 Biological_structure 603 612 digestive R14 MODIFY Arg1:T28 Arg2:E13 T29 Diagnostic_procedure 636 655 Computed tomography E14 Diagnostic_procedure:T29 T30 Sign_symptom 665 685 enlarged lymph nodes E15 Sign_symptom:T30 T31 Biological_structure 707 718 mediastinal T32 Biological_structure 720 735 retroperitoneal T33 Biological_structure 737 747 mesenteric T34 Biological_structure 753 761 inguinal R15 MODIFY Arg1:T31 Arg2:E15 R16 MODIFY Arg1:T32 Arg2:E15 R17 MODIFY Arg1:T33 Arg2:E15 R18 MODIFY Arg1:T34 Arg2:E15 T35 Sign_symptom 781 788 nodules E16 Sign_symptom:T35 T36 Detailed_description 767 780 intracavitary R19 MODIFY Arg1:T36 Arg2:E16 T37 Biological_structure 796 804 duodenum R20 MODIFY Arg1:T37 Arg2:E16 A4 POLARITY E13 MAYBE_POS T38 Diagnostic_procedure 868 871 EUS E17 Diagnostic_procedure:T38 T39 Diagnostic_procedure 876 882 biopsy E18 Diagnostic_procedure:T39 T40 Diagnostic_procedure 901 910 endoscopy E19 Diagnostic_procedure:T40 T41 Biological_structure 946 960 terminal ileum T42 Sign_symptom 923 938 columnar uplift E20 Sign_symptom:T42 T43 Area 914 922 2 × 1-cm R22 MODIFY Arg1:T43 Arg2:E20 T44 Sign_symptom 985 992 lesions E21 Sign_symptom:T44 T45 Biological_structure 1000 1006 rectum R23 MODIFY Arg1:T45 Arg2:E21 T46 Biological_structure 974 984 submucosal T47 Detailed_description 965 973 multiple R24 MODIFY Arg1:T46 Arg2:E21 R25 MODIFY Arg1:T47 Arg2:E21 T49 Sign_symptom 1054 1061 lesions E23 Sign_symptom:T49 T50 Biological_structure 1069 1083 terminal ileum R26 MODIFY Arg1:T50 Arg2:E23 R27 MODIFY Arg1:T41 Arg2:E20 T48 Diagnostic_procedure 1032 1035 EUS E22 Diagnostic_procedure:T48 R21 SUB_PROCEDURE Arg1:E19 Arg2:E17 T51 Area 1095 1107 1.6 × 1.2 cm R28 MODIFY Arg1:T51 Arg2:E23 T52 Sign_symptom 1116 1123 lesions E24 Sign_symptom:T52 T53 Biological_structure 1131 1137 rectum R29 MODIFY Arg1:T53 Arg2:E24 T54 Area 1156 1168 0.6 × 1.0 cm R30 MODIFY Arg1:T54 Arg2:E24 T55 Detailed_description 1184 1208 homogeneously hypoechoic T56 Detailed_description 1213 1256 originated from the muscularis mucosa layer R31 MODIFY Arg1:T55 Arg2:E24 R32 MODIFY Arg1:T56 Arg2:E24 T57 Diagnostic_procedure 1258 1282 Pathological examination E25 Diagnostic_procedure:T57 T58 Sign_symptom 1318 1325 lesions E26 Sign_symptom:T58 T59 Biological_structure 1333 1339 rectum R33 MODIFY Arg1:T59 Arg2:E26 T60 Detailed_description 1355 1381 lymphomatous proliferation R34 MODIFY Arg1:T60 Arg2:E26 T61 Detailed_description 1386 1404 dense infiltration R35 MODIFY Arg1:T61 Arg2:E26 T62 Biological_structure 1408 1471 monomorphic, small cleaved cells with irregularly shaped nuclei R36 MODIFY Arg1:T62 Arg2:T61 T63 Diagnostic_procedure 1484 1512 immunohistochemical analysis E27 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1542 1551 cyclin D1 E28 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1553 1557 CD20 E29 Diagnostic_procedure:T65 T66 Diagnostic_procedure 1559 1563 CD21 E30 Diagnostic_procedure:T66 T67 Diagnostic_procedure 1565 1571 SOX-11 E31 Diagnostic_procedure:T67 T68 Diagnostic_procedure 1577 1582 Bcl-2 E32 Diagnostic_procedure:T68 T69 Diagnostic_procedure 1601 1604 CD3 E33 Diagnostic_procedure:T69 T70 Diagnostic_procedure 1609 1613 CD10 E34 Diagnostic_procedure:T70 T71 Lab_value 1529 1537 positive T72 Lab_value 1588 1596 negative T73 Disease_disorder 1658 1661 MCL E35 Disease_disorder:T73 #1 AnnotatorNotes E35 Mantle cell lymphoma R37 MODIFY Arg1:T71 Arg2:E28 R38 MODIFY Arg1:T71 Arg2:E29 R39 MODIFY Arg1:T71 Arg2:E30 R40 MODIFY Arg1:T71 Arg2:E31 R41 MODIFY Arg1:T71 Arg2:E32 R42 MODIFY Arg1:T72 Arg2:E33 R43 MODIFY Arg1:T72 Arg2:E34 R44 SUB_PROCEDURE Arg1:E28 Arg2:E27 R45 SUB_PROCEDURE Arg1:E29 Arg2:E27 R46 SUB_PROCEDURE Arg1:E30 Arg2:E27 R47 SUB_PROCEDURE Arg1:E31 Arg2:E27 R48 SUB_PROCEDURE Arg1:E32 Arg2:E27 R49 SUB_PROCEDURE Arg1:E33 Arg2:E27 R50 SUB_PROCEDURE Arg1:E34 Arg2:E27 T74 Diagnostic_procedure 1663 1677 Ki-67 staining E36 Diagnostic_procedure:T74 T75 Lab_value 1689 1715 proliferative index of 30% R51 MODIFY Arg1:T75 Arg2:E36 T76 Disease_disorder 1778 1781 MCL E37 Disease_disorder:T76 T77 Lab_value 1759 1777 Ann Arbor stage IV R52 MODIFY Arg1:T77 Arg2:E37 T78 Medication 1838 1850 chemotherapy E38 Medication:T78 T79 Medication 1856 1865 rituximab E39 Medication:T79 T80 Medication 1867 1883 cyclophosphamide E40 Medication:T80 T81 Medication 1885 1896 doxorubicin E41 Medication:T81 T82 Medication 1898 1909 vincristine E42 Medication:T82 T83 Medication 1915 1925 prednisone E43 Medication:T83 T84 Medication 1927 1941 R-CHOP regimen E44 Medication:T84 R53 SUB_PROCEDURE Arg1:E39 Arg2:E38 R54 SUB_PROCEDURE Arg1:E39 Arg2:E44 R55 SUB_PROCEDURE Arg1:E40 Arg2:E38 R56 SUB_PROCEDURE Arg1:E41 Arg2:E38 R57 SUB_PROCEDURE Arg1:E42 Arg2:E38 R58 SUB_PROCEDURE Arg1:E43 Arg2:E38 R59 SUB_PROCEDURE Arg1:E40 Arg2:E44 R60 SUB_PROCEDURE Arg1:E41 Arg2:E44 R61 SUB_PROCEDURE Arg1:E42 Arg2:E44 R62 SUB_PROCEDURE Arg1:E43 Arg2:E44 T85 Sign_symptom 1968 1977 remission E45 Sign_symptom:T85 * OVERLAP E5 E6 E7 E8 E4 E3 E9 E11 E12 E13 E14 E15 E16 R63 BEFORE Arg1:E2 Arg2:E3 R64 BEFORE Arg1:E16 Arg2:E17 T86 Detailed_description 861 867 repeat R65 MODIFY Arg1:T86 Arg2:E17 * OVERLAP E17 E18 E20 E21 E22 E23 E24 E25 E26 E27 E35 E36 E37 R66 BEFORE Arg1:E37 Arg2:E38 R67 BEFORE Arg1:E38 Arg2:E45