--- a
+++ b/processing/MACCROBAT/28265107.ann
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+T1	Age 2 13	51-year-old
+T2	History 14 18	G1P1
+#1	AnnotatorNotes T2	One pregnancy, one birth
+T3	Personal_background 19 28	Caucasian
+T4	Sex 29 35	female
+T5	History 50 68	neurogenic bladder
+T6	History 82 102	spina bifida occulta
+T7	Sign_symptom 132 144	constipation
+E1	Sign_symptom:T7 
+T8	Sign_symptom 150 152	FI
+E2	Sign_symptom:T8 
+#2	AnnotatorNotes E2	Fecal incontinence
+T12	Therapeutic_procedure 227 246	manual disimpaction
+E4	Therapeutic_procedure:T12 
+T13	Detailed_description 218 226	frequent
+R2	MODIFY Arg1:T13 Arg2:E4	
+T14	Sign_symptom 307 320	fecal seepage
+E5	Sign_symptom:T14 
+T15	Frequency 275 287	twice weekly
+T16	Therapeutic_procedure 354 369	continence pads
+E6	Therapeutic_procedure:T16 
+T17	Frequency 348 353	daily
+R4	MODIFY Arg1:T17 Arg2:E6	
+R5	MODIFY Arg1:T15 Arg2:E5	
+T18	Severity 300 306	urgent
+R6	MODIFY Arg1:T18 Arg2:E5	
+T9	Activity 189 194	stool
+E3	Activity:T9 
+T10	Frequency 195 207	every 5 days
+R1	MODIFY Arg1:T10 Arg2:E3	
+T11	Diagnostic_procedure 172 184	Bristol Type
+E7	Diagnostic_procedure:T11 
+T19	Lab_value 185 188	1–2
+R3	MODIFY Arg1:T19 Arg2:E7	
+R7	MODIFY Arg1:E7 Arg2:E3	
+T20	Medication 421 429	psyllium
+E8	Medication:T20 
+T21	Medication 434 443	bisacodyl
+E9	Medication:T21 
+T22	Administration 444 457	suppositories
+R8	MODIFY Arg1:T22 Arg2:E9	
+R9	MODIFY Arg1:T22 Arg2:E8	
+T23	Diagnostic_procedure 461 473	defecography
+E10	Diagnostic_procedure:T23 
+T24	Sign_symptom 484 491	atrophy
+E11	Sign_symptom:T24 
+T25	Biological_structure 499 511	puborectalis
+R10	MODIFY Arg1:T25 Arg2:E11	
+T26	Sign_symptom 516 528	poor squeeze
+E12	Sign_symptom:T26 
+T27	Sign_symptom 545 552	atrophy
+E13	Sign_symptom:T27 
+T28	Biological_structure 534 544	EAS muscle
+R11	MODIFY Arg1:T28 Arg2:E13	
+#3	AnnotatorNotes T28	External anal sphincter
+T29	Diagnostic_procedure 554 573	Anorectal manometry
+E14	Diagnostic_procedure:T29 
+T30	Diagnostic_procedure 575 578	ARM
+E15	Diagnostic_procedure:T30 
+R12	IDENTICAL Arg1:E15 Arg2:E14	
+T31	Date 1386 1400	One year later
+E16	Date:T31 
+T32	Sign_symptom 1447 1459	constipation
+E17	Sign_symptom:T32 
+A1	TREND E17 DEC
+T33	Sign_symptom 1464 1466	FI
+E18	Sign_symptom:T33 
+A2	TREND E18 DEC
+T34	Therapeutic_procedure 1239 1258	biofeedback therapy
+E19	Therapeutic_procedure:T34 
+T35	Detailed_description 1226 1238	conventional
+T36	Detailed_description 1217 1221	home
+R13	MODIFY Arg1:T35 Arg2:E19	
+R14	MODIFY Arg1:T36 Arg2:E19	
+T37	Sign_symptom 1201 1211	management
+E20	Sign_symptom:T37 
+A3	POLARITY E20 NEG
+T38	Therapeutic_procedure 1302 1305	SNS
+E21	Therapeutic_procedure:T38 
+#4	AnnotatorNotes E21	sacral neuromodulation
+T39	Detailed_description 1292 1301	temporary
+R15	MODIFY Arg1:T39 Arg2:E21	
+T40	Therapeutic_procedure 1374 1377	SNS
+E22	Therapeutic_procedure:T40 
+T41	Detailed_description 1364 1373	permanent
+R16	MODIFY Arg1:T41 Arg2:E22	
+T42	Sign_symptom 1326 1328	FI
+E23	Sign_symptom:T42 
+A4	TREND E23 DEC
+T43	Lab_value 1341 1344	75%
+R17	MODIFY Arg1:T43 Arg2:E23	
+T44	Diagnostic_procedure 596 612	resting pressure
+E24	Diagnostic_procedure:T44 
+T45	Lab_value 589 595	normal
+R18	MODIFY Arg1:T45 Arg2:E24	
+T46	Disease_disorder 671 679	weak EAS
+E25	Disease_disorder:T46 
+T47	Sign_symptom 621 653	augmentation of squeeze pressure
+E26	Sign_symptom:T47 
+A5	POLARITY E26 NEG
+T48	Sign_symptom 713 735	fixed perineal descent
+E27	Sign_symptom:T48 
+T49	Disease_disorder 868 870	DD
+E28	Disease_disorder:T49 
+#5	AnnotatorNotes E28	dyssynergic defecation
+T50	Activity 699 711	bearing down
+E29	Activity:T50 
+T51	Activity 877 884	pushing
+E30	Activity:T51 
+T52	Diagnostic_procedure 778 803	posterior anorectal angle
+E31	Diagnostic_procedure:T52 
+T53	Lab_value 755 773	inability to widen
+R19	MODIFY Arg1:T53 Arg2:E31	
+T54	Diagnostic_procedure 813 835	evacuation of contrast
+E32	Diagnostic_procedure:T54 
+T55	Lab_value 808 812	poor
+R20	MODIFY Arg1:T55 Arg2:E32	
+T56	Sign_symptom 841 850	straining
+E33	Sign_symptom:T56 
+T57	Diagnostic_procedure 886 889	ARM
+E34	Diagnostic_procedure:T57 
+T58	Disease_disorder 921 923	DD
+E35	Disease_disorder:T58 
+T59	Lab_value 913 920	type IV
+R21	MODIFY Arg1:T59 Arg2:E35	
+T60	Diagnostic_procedure 1078 1104	Reflex and sensory testing
+E36	Diagnostic_procedure:T60 
+T61	Diagnostic_procedure 1125 1152	rectoanal inhibitory reflex
+E37	Diagnostic_procedure:T61 
+T62	Lab_value 1118 1124	intact
+R22	MODIFY Arg1:T62 Arg2:E37	
+T63	Sign_symptom 1164 1180	hypersensitivity
+E38	Sign_symptom:T63 
+T64	Biological_structure 1157 1163	rectal
+R23	MODIFY Arg1:T64 Arg2:E38	
+T65	Clinical_event 107 115	referred
+E39	Clinical_event:T65 
+R24	AFTER Arg1:E39 Arg2:E1	
+*	OVERLAP E1 E2 E7 E3 E4 E5 E6 E8 E9
+R25	BEFORE Arg1:E9 Arg2:E10	
+*	OVERLAP E10 E11 E12 E13 E14 E24 E26 E25
+R26	BEFORE Arg1:E25 Arg2:E29	
+*	OVERLAP E29 E27 E31 E32 E33 E28
+R27	BEFORE Arg1:E28 Arg2:E30	
+*	OVERLAP E30 E34 E35 E36 E37 E38
+R28	BEFORE Arg1:E38 Arg2:E20	
+*	OVERLAP E20 E19
+R29	BEFORE Arg1:E19 Arg2:E21	
+*	OVERLAP E21 E23
+R30	BEFORE Arg1:E23 Arg2:E22	
+R31	BEFORE Arg1:E22 Arg2:E16	
+*	OVERLAP E16 E17 E18