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T1 Age 2 13 34-year-old T2 Personal_background 14 22 Hispanic T3 Sex 23 27 male T4 History 28 68 without significant past medical history T5 Clinical_event 69 78 presented E1 Clinical_event:T5 T6 Nonbiological_location 86 94 hospital R1 MODIFY Arg1:T6 Arg2:E1 T7 Duration 102 111 one month E2 Duration:T7 T8 Sign_symptom 123 128 cough E3 Sign_symptom:T8 T9 Sign_symptom 152 158 sputum E4 Sign_symptom:T9 T10 Color 144 151 whitish R2 MODIFY Arg1:T10 Arg2:E4 T11 Sign_symptom 187 192 fever E5 Sign_symptom:T11 A1 POLARITY E5 NEG T12 Sign_symptom 194 200 chills E6 Sign_symptom:T12 A2 POLARITY E6 NEG T13 Sign_symptom 202 214 night sweats E7 Sign_symptom:T13 A3 POLARITY E7 NEG T14 Sign_symptom 222 226 pain E8 Sign_symptom:T14 A4 POLARITY E8 NEG T15 Biological_structure 216 221 chest R3 MODIFY Arg1:T15 Arg2:E8 T16 Sign_symptom 228 238 hemoptysis E9 Sign_symptom:T16 A5 POLARITY E9 NEG T17 Sign_symptom 245 249 pain E10 Sign_symptom:T17 A6 POLARITY E10 NEG T18 Biological_structure 240 244 back R4 MODIFY Arg1:T18 Arg2:E10 T19 Clinical_event 258 264 travel E11 Clinical_event:T19 A7 POLARITY E11 NEG T20 Clinical_event 273 281 contacts E12 Clinical_event:T20 A8 POLARITY E12 NEG T21 Detailed_description 251 257 recent T22 Detailed_description 268 272 sick R5 MODIFY Arg1:T22 Arg2:E12 R6 MODIFY Arg1:T21 Arg2:E11 T23 Sign_symptom 335 346 weight loss E13 Sign_symptom:T23 R7 MODIFY Arg1:E4 Arg2:E3 T24 Lab_value 323 334 15–20 pound R8 MODIFY Arg1:T24 Arg2:E13 T25 Duration 358 373 last six months E14 Duration:T25 T27 History 378 392 denied smoking T28 History 403 416 drank alcohol T29 History 422 479 had unprotected sexual intercourse with multiple partners T26 Diagnostic_procedure 511 522 temperature E15 Diagnostic_procedure:T26 T30 Lab_value 527 533 97.9°F R9 MODIFY Arg1:T30 Arg2:E15 T31 Diagnostic_procedure 535 545 heart rate E16 Diagnostic_procedure:T31 T32 Lab_value 550 569 85 beats per minute R10 MODIFY Arg1:T32 Arg2:E16 T33 Diagnostic_procedure 571 587 respiratory rate E17 Diagnostic_procedure:T33 T34 Lab_value 592 613 16 breaths per minute R11 MODIFY Arg1:T34 Arg2:E17 T35 Diagnostic_procedure 615 629 blood pressure E18 Diagnostic_procedure:T35 T36 Lab_value 634 646 107/66 mm Hg R12 MODIFY Arg1:T36 Arg2:E18 T37 Diagnostic_procedure 652 669 oxygen saturation E19 Diagnostic_procedure:T37 T38 Lab_value 674 678 100% T39 Detailed_description 682 690 room air R13 MODIFY Arg1:T39 Arg2:E19 R14 MODIFY Arg1:T38 Arg2:E19 T40 Diagnostic_procedure 692 703 Examination E20 Diagnostic_procedure:T40 T41 Sign_symptom 716 722 thrush E21 Sign_symptom:T41 T42 Biological_structure 711 715 oral R15 MODIFY Arg1:T42 Arg2:E21 T43 Diagnostic_procedure 734 747 breath sounds E22 Diagnostic_procedure:T43 T44 Lab_value 724 733 decreased R16 MODIFY Arg1:T44 Arg2:E22 T45 Sign_symptom 752 760 crackles E23 Sign_symptom:T45 T46 Biological_structure 768 789 right lower lung base R17 MODIFY Arg1:T46 Arg2:E23 T47 Sign_symptom 804 811 lesions E24 Sign_symptom:T47 A9 POLARITY E24 NEG T48 Biological_structure 794 803 cutaneous R18 MODIFY Arg1:T48 Arg2:E24 T49 Diagnostic_procedure 842 862 clinical examination E25 Diagnostic_procedure:T49 T50 Lab_value 867 879 unremarkable R19 MODIFY Arg1:T50 Arg2:E25 T51 Diagnostic_procedure 885 905 complete blood count E26 Diagnostic_procedure:T51 T52 Diagnostic_procedure 907 910 CBC E27 Diagnostic_procedure:T52 R20 IDENTICAL Arg1:E27 Arg2:E26 T53 Diagnostic_procedure 919 929 hemoglobin E28 Diagnostic_procedure:T53 T54 Lab_value 933 941 9.7 g/dL R21 MODIFY Arg1:T54 Arg2:E28 T55 Diagnostic_procedure 943 947 WBCs E29 Diagnostic_procedure:T55 T56 Lab_value 948 957 2.3×109/L R22 MODIFY Arg1:T56 Arg2:E29 T57 Diagnostic_procedure 963 972 platelets E30 Diagnostic_procedure:T57 T58 Lab_value 976 985 164×109/L R23 MODIFY Arg1:T58 Arg2:E30 R24 SUB_PROCEDURE Arg1:E28 Arg2:E26 R25 SUB_PROCEDURE Arg1:E29 Arg2:E26 R26 SUB_PROCEDURE Arg1:E30 Arg2:E26 T59 Diagnostic_procedure 991 1001 creatinine E31 Diagnostic_procedure:T59 T60 Lab_value 1006 1016 0.62 mg/dL R27 MODIFY Arg1:T60 Arg2:E31 T61 Diagnostic_procedure 1022 1041 blood urea nitrogen E32 Diagnostic_procedure:T61 T62 Lab_value 1046 1054 10 mg/dL R28 MODIFY Arg1:T62 Arg2:E32 T63 Diagnostic_procedure 1056 1066 Radiograph E33 Diagnostic_procedure:T63 T64 Biological_structure 1074 1079 chest R29 MODIFY Arg1:T64 Arg2:E33 T65 Sign_symptom 1122 1129 opacity E34 Sign_symptom:T65 T66 Biological_structure 1112 1121 perihilar R30 MODIFY Arg1:T66 Arg2:E34 T67 Severity 1087 1096 extensive R31 MODIFY Arg1:T67 Arg2:E34 T68 Biological_structure 1097 1102 right T69 Biological_structure 1107 1111 left R32 MODIFY Arg1:T69 Arg2:E34 R33 MODIFY Arg1:T68 Arg2:E34 T70 Biological_structure 1130 1152 more on the right side R34 MODIFY Arg1:T70 Arg2:E34 T71 Diagnostic_procedure 1158 1177 computed tomography E35 Diagnostic_procedure:T71 T72 Diagnostic_procedure 1179 1181 CT E36 Diagnostic_procedure:T72 R35 IDENTICAL Arg1:E36 Arg2:E35 T73 Biological_structure 1195 1200 chest R36 MODIFY Arg1:T73 Arg2:E35 T74 Sign_symptom 1238 1242 mass E37 Sign_symptom:T74 T75 Biological_structure 1228 1237 perihilar R37 MODIFY Arg1:T75 Arg2:E37 T76 Sign_symptom 1328 1335 lesions E38 Sign_symptom:T76 T77 Detailed_description 1259 1267 multiple T78 Biological_structure 1288 1297 vertebrae T79 Biological_structure 1281 1287 lumbar T80 Biological_structure 1268 1276 thoracic R38 MODIFY Arg1:T79 Arg2:T78 R39 MODIFY Arg1:T80 Arg2:T78 T81 Biological_structure 1299 1303 ribs T82 Biological_structure 1309 1316 sternal T83 Severity 1317 1321 tiny T84 Detailed_description 1322 1327 lytic R40 MODIFY Arg1:T84 Arg2:E38 R41 MODIFY Arg1:T83 Arg2:E38 R42 MODIFY Arg1:T82 Arg2:E38 R43 MODIFY Arg1:T81 Arg2:E38 T85 Severity 1222 1227 large R44 MODIFY Arg1:T85 Arg2:E37 T86 Biological_structure 1210 1221 right sided R45 MODIFY Arg1:T86 Arg2:E37 R46 MODIFY Arg1:T77 Arg2:E38 R47 MODIFY Arg1:T78 Arg2:E38 T87 Disease_disorder 1357 1367 metastasis E39 Disease_disorder:T87 T88 Biological_structure 1352 1356 bony R48 MODIFY Arg1:T88 Arg2:E39 T89 Diagnostic_procedure 1397 1405 cultures E40 Diagnostic_procedure:T89 T90 Biological_structure 1390 1396 sputum T91 Biological_structure 1380 1385 Blood R49 MODIFY Arg1:T90 Arg2:E40 R50 MODIFY Arg1:T91 Arg2:E40 T92 Lab_value 1411 1419 negative R51 MODIFY Arg1:T92 Arg2:E40 T93 Disease_disorder 1421 1433 Tuberculosis E41 Disease_disorder:T93 A10 POLARITY E41 NEG T94 Diagnostic_procedure 1478 1491 sputum smears E42 Diagnostic_procedure:T94 T95 Detailed_description 1496 1513 acid fast bacilli R52 MODIFY Arg1:T95 Arg2:E42 T96 Detailed_description 1451 1468 three consecutive T97 Lab_value 1469 1477 negative R53 MODIFY Arg1:T96 Arg2:T97 R54 MODIFY Arg1:T97 Arg2:E42 T98 Diagnostic_procedure 1529 1550 QUANTIferon gold test E43 Diagnostic_procedure:T98 T99 Lab_value 1520 1528 negative R55 MODIFY Arg1:T99 Arg2:E43 T100 Lab_value 1562 1570 positive T101 Diagnostic_procedure 1575 1603 human immunodeficiency virus E44 Diagnostic_procedure:T101 T102 Diagnostic_procedure 1605 1608 HIV E45 Diagnostic_procedure:T102 R56 IDENTICAL Arg1:E45 Arg2:E44 R57 MODIFY Arg1:T100 Arg2:E44 #1 AnnotatorNotes E44 This is a test with a positive result, so it's also diagnosis of the infection T103 Disease_disorder 1575 1603 human immunodeficiency virus E46 Disease_disorder:T103 T104 Disease_disorder 1605 1608 HIV E47 Disease_disorder:T104 R58 IDENTICAL Arg1:E47 Arg2:E46 T105 Diagnostic_procedure 1618 1628 CD4 counts E48 Diagnostic_procedure:T105 T106 Lab_value 1642 1652 7 cells/uL R59 MODIFY Arg1:T106 Arg2:E48 T107 Therapeutic_procedure 1672 1683 prophylaxis E49 Therapeutic_procedure:T107 T108 Medication 1689 1696 bactrim E50 Medication:T108 T109 Dosage 1697 1712 80–160 mg daily R60 MODIFY Arg1:T109 Arg2:E50 T110 Medication 1717 1729 azithromycin E51 Medication:T110 T111 Dosage 1730 1744 1200 mg weekly R61 MODIFY Arg1:T111 Arg2:E51 T112 Diagnostic_procedure 1775 1787 Bronchoscopy E52 Diagnostic_procedure:T112 T113 Diagnostic_procedure 1793 1799 biopsy E53 Diagnostic_procedure:T113 T114 Lab_value 1822 1833 unrevealing R62 MODIFY Arg1:T114 Arg2:E52 T115 Diagnostic_procedure 1868 1883 mediastinoscopy E54 Diagnostic_procedure:T115 T116 Diagnostic_procedure 1889 1897 biopsies E55 Diagnostic_procedure:T116 T117 Detailed_description 1853 1867 video assisted R63 MODIFY Arg1:T117 Arg2:E54 T118 Biological_structure 1905 1916 right hilar T119 Sign_symptom 1917 1921 mass E56 Sign_symptom:T119 R64 MODIFY Arg1:T118 Arg2:E56 R65 MODIFY Arg1:E56 Arg2:E55 T120 Diagnostic_procedure 1923 1932 Pathology E57 Diagnostic_procedure:T120 T121 Sign_symptom 1940 1953 spindle cells E58 Sign_symptom:T121 T122 Diagnostic_procedure 1967 1971 CD34 E59 Diagnostic_procedure:T122 T123 Diagnostic_procedure 1973 1977 BCL2 E60 Diagnostic_procedure:T123 T124 Diagnostic_procedure 1979 1987 vimentin E61 Diagnostic_procedure:T124 T125 Diagnostic_procedure 1993 1998 HHV-8 E62 Diagnostic_procedure:T125 T126 Lab_value 1954 1962 positive R66 MODIFY Arg1:T126 Arg2:E59 R67 MODIFY Arg1:T126 Arg2:E60 R68 MODIFY Arg1:T126 Arg2:E61 R69 MODIFY Arg1:T126 Arg2:E62 T127 Diagnostic_procedure 2027 2031 CD31 E63 Diagnostic_procedure:T127 T128 Lab_value 2012 2022 positivity R70 MODIFY Arg1:T128 Arg2:E63 T129 Detailed_description 2004 2011 diffuse R71 MODIFY Arg1:T129 Arg2:T128 R72 MODIFY Arg1:E58 Arg2:E59 R73 MODIFY Arg1:E58 Arg2:E60 R74 MODIFY Arg1:E58 Arg2:E61 R75 MODIFY Arg1:E58 Arg2:E62 R76 MODIFY Arg1:E58 Arg2:E63 T130 Disease_disorder 2046 2048 KS E64 Disease_disorder:T130 #2 AnnotatorNotes E64 Kaposi Sarcoma T131 Medication 2076 2081 HAART E65 Medication:T131 R77 SUB_PROCEDURE Arg1:E50 Arg2:E49 R78 SUB_PROCEDURE Arg1:E51 Arg2:E49 T132 Medication 2097 2144 emtricitabine and tenofovir disoproxil fumarate E66 Medication:T132 T133 Lab_value 2145 2155 200/300 mg R79 MODIFY Arg1:T133 Arg2:E66 T134 Medication 2160 2172 dolutegravir E67 Medication:T134 T135 Lab_value 2173 2178 50 mg R80 MODIFY Arg1:T135 Arg2:E67 T136 Medication 2299 2322 additional chemotherapy E68 Medication:T136 A11 POLARITY E68 NEG T137 Sign_symptom 2356 2376 clinical improvement E69 Sign_symptom:T137 T138 Diagnostic_procedure 2387 2389 CT E70 Diagnostic_procedure:T138 T139 Biological_structure 2402 2407 chest R81 MODIFY Arg1:T139 Arg2:E70 T140 Date 2411 2423 three months E71 Date:T140 T141 Sign_symptom 2440 2450 regression E72 Sign_symptom:T141 T142 Sign_symptom 2500 2507 lesions E73 Sign_symptom:T142 A12 POLARITY E73 MAYBE_NEG R82 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 E4 R83 BEFORE Arg1:E4 Arg2:E5 * OVERLAP E5 E6 E7 E8 E9 E10 E11 E12 R84 AFTER Arg1:E12 Arg2:E13 * OVERLAP E13 E14 E76 E77 E78 * OVERLAP E15 E16 E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E31 E32 E33 E34 E35 E37 E38 E39 E40 E41 E42 E43 E44 E46 E48 R86 BEFORE Arg1:E48 Arg2:E49 * OVERLAP E49 E52 E53 E54 E55 E57 E58 E59 E60 E61 E62 E63 E64 R87 BEFORE Arg1:E64 Arg2:E65 R88 SUB_PROCEDURE Arg1:E66 Arg2:E65 R89 SUB_PROCEDURE Arg1:E67 Arg2:E65 T143 Clinical_event 2217 2226 decisions E74 Clinical_event:T143 T144 Detailed_description 2237 2255 management options R90 MODIFY Arg1:T144 Arg2:E74 T145 Detailed_description 2196 2213 actively involved R91 MODIFY Arg1:T145 Arg2:E74 R92 BEFORE Arg1:E65 Arg2:E74 T146 Medication 2268 2273 HAART E75 Medication:T146 R93 BEFORE Arg1:E74 Arg2:E75 * OVERLAP E75 E68 R94 BEFORE Arg1:E68 Arg2:E69 * OVERLAP E69 E70 E71 E72 E73 T147 Activity 385 392 smoking E76 Activity:T147 A13 POLARITY E76 NEG T148 Activity 403 416 drank alcohol E77 Activity:T148 T149 Activity 438 456 sexual intercourse E78 Activity:T149 T150 Detailed_description 426 437 unprotected T151 Detailed_description 462 479 multiple partners R95 MODIFY Arg1:T150 Arg2:E78 R96 MODIFY Arg1:T151 Arg2:E78 R85 BEFORE Arg1:E78 Arg2:E15