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T1 Age 18 29 48-year-old T2 Sex 30 33 man T3 Clinical_event 58 70 hospitalized E1 Clinical_event:T3 T4 Sign_symptom 78 88 hemoptysis E2 Sign_symptom:T4 T5 Date 89 107 at 42 years of age E3 Date:T5 T6 Diagnostic_procedure 131 141 radiograph E4 Diagnostic_procedure:T6 T7 Biological_structure 125 130 chest T8 Biological_structure 146 151 chest T9 Diagnostic_procedure 152 171 computed tomography E5 Diagnostic_procedure:T9 T10 Diagnostic_procedure 173 175 CT E6 Diagnostic_procedure:T10 R1 IDENTICAL Arg1:E6 Arg2:E5 T11 Sign_symptom 194 214 ground-glass opacity E7 Sign_symptom:T11 T12 Detailed_description 186 193 diffuse R2 MODIFY Arg1:T12 Arg2:E7 T13 Sign_symptom 216 219 GGO E8 Sign_symptom:T13 R3 IDENTICAL Arg1:E8 Arg2:E7 T14 Biological_structure 228 242 bilateral lung R4 MODIFY Arg1:T14 Arg2:E7 T15 Diagnostic_procedure 267 292 bronchoscopic examination E9 Diagnostic_procedure:T15 T16 Sign_symptom 306 318 accumulation E10 Sign_symptom:T16 T17 Detailed_description 339 344 blood R5 MODIFY Arg1:T17 Arg2:E10 T18 Severity 322 335 large amounts R6 MODIFY Arg1:T18 Arg2:E10 T19 Biological_structure 352 359 trachea T20 Biological_structure 364 371 bronchi R7 MODIFY Arg1:T19 Arg2:E10 R8 MODIFY Arg1:T20 Arg2:E10 T21 Diagnostic_procedure 395 423 bronchoalveolar lavage fluid E11 Diagnostic_procedure:T21 T22 Diagnostic_procedure 425 429 BALF E12 Diagnostic_procedure:T22 R9 IDENTICAL Arg1:E12 Arg2:E11 T23 Lab_value 435 441 bloody E13 Lab_value:T23 T24 Lab_value 465 494 hemosiderin-laden macrophages E14 Lab_value:T24 R10 MODIFY Arg1:E14 Arg2:E11 T25 Diagnostic_procedure 498 510 culture test E15 Diagnostic_procedure:T25 T26 Diagnostic_procedure 518 522 BALF E16 Diagnostic_procedure:T26 R11 SUB_PROCEDURE Arg1:E15 Arg2:E16 T27 Lab_value 532 543 no findings E17 Lab_value:T27 R12 MODIFY Arg1:E17 Arg2:E15 T28 Diagnostic_procedure 548 565 electrocardiogram E18 Diagnostic_procedure:T28 T29 Diagnostic_procedure 584 598 echocardiogram E19 Diagnostic_procedure:T29 T30 Biological_structure 570 583 transthoracic R13 MODIFY Arg1:T30 Arg2:E19 T31 Lab_value 608 624 no abnormalities E20 Lab_value:T31 R14 MODIFY Arg1:E20 Arg2:E19 R15 MODIFY Arg1:E20 Arg2:E18 T32 Family_history 790 845 younger brother who had been diagnosed with hepatitis C T33 Subject 790 805 younger brother T34 Disease_disorder 834 845 hepatitis C E21 Disease_disorder:T34 R16 MODIFY Arg1:T33 Arg2:E21 T35 Sign_symptom 703 722 hemorrhagic episode E22 Sign_symptom:T35 T36 Other_event 628 641 questionnaire E23 Other_event:T36 T37 Medication 884 889 drugs E24 Medication:T37 A1 POLARITY E24 NEG T38 Detailed_description 903 925 potential to cause DAH R17 MODIFY Arg1:T38 Arg2:E24 T39 Disease_disorder 971 974 DAH E25 Disease_disorder:T39 #1 AnnotatorNotes E25 Diffuse alveolar hemorrhage T40 Disease_disorder 995 1005 vasculitis E26 Disease_disorder:T40 A2 POLARITY E26 UNCERTAIN R18 CAUSE Arg1:E26 Arg2:E25 T41 Medication 1064 1082 methylprednisolone E27 Medication:T41 T42 Dosage 1084 1098 1,000 mg daily R19 MODIFY Arg1:T42 Arg2:E27 T43 Administration 1052 1063 intravenous R20 MODIFY Arg1:T43 Arg2:E27 T44 Duration 1104 1110 3 days E28 Duration:T44 T45 Medication 1123 1135 prednisolone E29 Medication:T45 T46 Dosage 1137 1148 25 mg daily R21 MODIFY Arg1:T46 Arg2:E29 T47 Sign_symptom 1183 1191 symptoms E30 Sign_symptom:T47 A3 POLARITY E30 NEG T48 Diagnostic_procedure 1199 1201 CT E31 Diagnostic_procedure:T48 T49 Biological_structure 1193 1198 Chest R22 MODIFY Arg1:T49 Arg2:E31 T50 Sign_symptom 1231 1234 GGO E32 Sign_symptom:T50 A4 POLARITY E32 NEG T51 Medication 1250 1262 prednisolone E33 Medication:T51 T52 Dosage 1272 1279 tapered T53 Dosage 1295 1307 discontinued R23 MODIFY Arg1:T52 Arg2:E33 R24 MODIFY Arg1:T53 Arg2:E33 T54 Date 1311 1331 two-and-a-half years E34 Date:T54 T55 Clinical_event 1342 1351 discharge E35 Clinical_event:T55 T56 Nonbiological_location 1361 1369 hospital R25 MODIFY Arg1:T56 Arg2:E35 T57 Clinical_event 1387 1397 readmitted E36 Clinical_event:T57 T58 Nonbiological_location 1405 1413 hospital R26 MODIFY Arg1:T58 Arg2:E36 T59 Sign_symptom 1435 1445 hemoptysis E37 Sign_symptom:T59 T60 Date 1446 1464 at 46 years of age E38 Date:T60 T62 Medication 1557 1569 prednisolone E40 Medication:T62 T63 Dosage 1579 1586 tapered T64 Dosage 1592 1603 60 mg daily T65 Dosage 1629 1639 5 mg daily R27 MODIFY Arg1:T63 Arg2:E40 R28 MODIFY Arg1:T64 Arg2:E40 R29 MODIFY Arg1:T65 Arg2:E40 T66 Date 1641 1659 At 48 years of age E41 Date:T66 T67 Clinical_event 1668 1678 readmitted E42 Clinical_event:T67 T68 Nonbiological_location 1686 1694 hospital R30 MODIFY Arg1:T68 Arg2:E42 T69 Sign_symptom 1724 1734 hemoptysis E43 Sign_symptom:T69 T70 Medication 1758 1765 steroid E44 Medication:T70 T71 Disease_disorder 1774 1791 diabetes mellitus E45 Disease_disorder:T71 R31 CAUSE Arg1:E44 Arg2:E45 T72 Medication 1816 1827 glimepiride E46 Medication:T72 T73 Dosage 1829 1839 3 mg daily R32 MODIFY Arg1:T73 Arg2:E46 T74 Clinical_event 1845 1854 admission E47 Clinical_event:T74 T75 Diagnostic_procedure 1860 1866 weight E48 Diagnostic_procedure:T75 T76 Lab_value 1871 1876 75 kg E49 Lab_value:T76 T77 Diagnostic_procedure 1881 1887 height E50 Diagnostic_procedure:T77 T78 Lab_value 1888 1894 167 cm E51 Lab_value:T78 R33 MODIFY Arg1:E49 Arg2:E48 R34 MODIFY Arg1:E51 Arg2:E50 T79 Diagnostic_procedure 1900 1911 vital signs E52 Diagnostic_procedure:T79 T80 Diagnostic_procedure 1929 1943 blood pressure E53 Diagnostic_procedure:T80 T81 Lab_value 1945 1957 178/102 mmHg E54 Lab_value:T81 R35 MODIFY Arg1:E54 Arg2:E53 T82 Diagnostic_procedure 1959 1969 pulse rate E55 Diagnostic_procedure:T82 T83 Lab_value 1971 1984 109 beats/min E56 Lab_value:T83 R36 MODIFY Arg1:E56 Arg2:E55 T84 Diagnostic_procedure 1986 2000 pulse oximetry E57 Diagnostic_procedure:T84 T85 Lab_value 2002 2005 97% E58 Lab_value:T85 T86 Detailed_description 2009 2017 room air R37 MODIFY Arg1:T86 Arg2:E57 R38 MODIFY Arg1:E58 Arg2:E57 T87 Diagnostic_procedure 2023 2039 body temperature E59 Diagnostic_procedure:T87 T88 Lab_value 2041 2047 36.8°C E60 Lab_value:T88 R39 MODIFY Arg1:E60 Arg2:E59 R40 SUB_PROCEDURE Arg1:E53 Arg2:E52 R41 SUB_PROCEDURE Arg1:E55 Arg2:E52 R42 SUB_PROCEDURE Arg1:E57 Arg2:E52 R43 SUB_PROCEDURE Arg1:E59 Arg2:E52 T89 Diagnostic_procedure 2055 2067 auscultation E61 Diagnostic_procedure:T89 T90 Biological_structure 2049 2054 Chest R44 MODIFY Arg1:T90 Arg2:E61 T91 Sign_symptom 2082 2090 crackles E62 Sign_symptom:T91 T92 Detailed_description 2077 2081 fine R45 MODIFY Arg1:T92 Arg2:E62 T93 Biological_structure 2098 2108 right lung R46 MODIFY Arg1:T93 Arg2:E62 T94 Sign_symptom 2124 2128 rash E63 Sign_symptom:T94 A5 POLARITY E63 NEG T95 Biological_structure 2119 2123 skin R47 MODIFY Arg1:T95 Arg2:E63 T96 Sign_symptom 2143 2151 bleeding E64 Sign_symptom:T96 A6 POLARITY E64 NEG T97 Sign_symptom 2161 2169 swelling E65 Sign_symptom:T97 A7 POLARITY E65 NEG T98 Biological_structure 2155 2160 joint T99 Biological_structure 2130 2142 subcutaneous R48 MODIFY Arg1:T99 Arg2:E64 R49 MODIFY Arg1:T98 Arg2:E65 T100 Diagnostic_procedure 2192 2202 radiograph E66 Diagnostic_procedure:T100 T101 Biological_structure 2186 2191 chest T102 Diagnostic_procedure 2207 2209 CT E67 Diagnostic_procedure:T102 R50 MODIFY Arg1:T101 Arg2:E66 R51 MODIFY Arg1:T101 Arg2:E67 T103 Sign_symptom 2241 2244 GGO E68 Sign_symptom:T103 T104 Detailed_description 2233 2240 diffuse R52 MODIFY Arg1:T104 Arg2:E68 T105 Biological_structure 2252 2266 bilateral lung R53 MODIFY Arg1:T105 Arg2:E68 T106 Sign_symptom 2280 2286 anemia E69 Sign_symptom:T106 T107 Severity 2275 2279 Mild R54 MODIFY Arg1:T107 Arg2:E69 T108 Diagnostic_procedure 2301 2311 hemoglobin E70 Diagnostic_procedure:T108 T109 Lab_value 2313 2322 11.3 g/dL E71 Lab_value:T109 R55 BEFORE Arg1:E71 Arg2:E70 T110 Diagnostic_procedure 2334 2344 hemoglobin E72 Diagnostic_procedure:T110 T111 Lab_value 2361 2370 14.6 g/dL E73 Lab_value:T111 R56 MODIFY Arg1:E73 Arg2:E72 T112 Diagnostic_procedure 2408 2445 activated partial thromboplastin time E74 Diagnostic_procedure:T112 T113 Diagnostic_procedure 2447 2451 APTT E75 Diagnostic_procedure:T113 R57 IDENTICAL Arg1:E75 Arg2:E74 T114 Lab_value 2470 2482 53.5 seconds E76 Lab_value:T114 T115 Lab_value 2457 2466 prolonged E77 Lab_value:T115 R58 MODIFY Arg1:E77 Arg2:E74 R59 MODIFY Arg1:E76 Arg2:E74 T116 Sign_symptom 2384 2394 hemoptysis E78 Sign_symptom:T116 T117 Diagnostic_procedure 2518 2534 Laboratory tests E79 Diagnostic_procedure:T117 T118 Diagnostic_procedure 2561 2574 blood glucose E80 Diagnostic_procedure:T118 T119 Diagnostic_procedure 2579 2593 hemoglobin A1c E81 Diagnostic_procedure:T119 T120 Lab_value 2606 2615 299 mg/dL E82 Lab_value:T120 T121 Lab_value 2620 2624 8.2% E83 Lab_value:T121 R60 MODIFY Arg1:E82 Arg2:E80 R61 MODIFY Arg1:E83 Arg2:E81 T122 Disease_disorder 2667 2684 diabetes mellitus E84 Disease_disorder:T122 T123 Medication 2651 2658 steroid E85 Medication:T123 R62 CAUSE Arg1:E85 Arg2:E84 T124 Diagnostic_procedure 2686 2730 Autoantibodies for various collagen diseases E86 Diagnostic_procedure:T124 T125 Lab_value 2736 2744 negative E87 Lab_value:T125 R63 MODIFY Arg1:E87 Arg2:E86 T126 Disease_disorder 2800 2803 DAH E88 Disease_disorder:T126 T127 Medication 2849 2867 methylprednisolone E89 Medication:T127 T128 Administration 2837 2848 intravenous T129 Duration 2872 2878 3 days E90 Duration:T129 T130 Dosage 2827 2836 high-dose R64 MODIFY Arg1:T128 Arg2:E89 R65 MODIFY Arg1:T130 Arg2:E89 T131 Medication 2892 2904 prednisolone E91 Medication:T131 T132 Dosage 2906 2917 60 mg daily R66 MODIFY Arg1:T132 Arg2:E91 T61 Diagnostic_procedure 1542 1551 condition E39 Diagnostic_procedure:T61 T133 Lab_value 1523 1534 improvement E92 Lab_value:T133 R67 MODIFY Arg1:E92 Arg2:E39 T134 Diagnostic_procedure 2924 2933 condition E93 Diagnostic_procedure:T134 T135 Lab_value 2934 2942 improved E94 Lab_value:T135 R68 MODIFY Arg1:E94 Arg2:E93 T136 Date 3077 3108 as an elementary school student E95 Date:T136 T137 Clinical_event 3122 3134 hospitalized E96 Clinical_event:T137 T138 History 3077 3134 as an elementary school student, he had been hospitalized T139 History 3139 3235 had received blood transfusions twice following abnormally heavy bleeding after tooth extraction T140 Therapeutic_procedure 3152 3170 blood transfusions E97 Therapeutic_procedure:T140 T141 Quantitative_concept 3171 3176 twice R69 MODIFY Arg1:T141 Arg2:E97 T142 Disease_disorder 3204 3212 bleeding E98 Disease_disorder:T142 T143 Severity 3187 3203 abnormally heavy R70 MODIFY Arg1:T143 Arg2:E98 T144 Therapeutic_procedure 3219 3235 tooth extraction E99 Therapeutic_procedure:T144 R71 CAUSE Arg1:E99 Arg2:E98 T145 Date 3309 3321 at that time E100 Date:T145 T146 Disease_disorder 3268 3285 bleeding disorder E101 Disease_disorder:T146 A8 POLARITY E101 UNCERTAIN T147 Detailed_description 3257 3267 congenital R72 MODIFY Arg1:T147 Arg2:E101 T148 Family_history 3353 3424 younger brother had been diagnosed with hemophilia B during adolescence T149 Subject 3353 3368 younger brother T150 Disease_disorder 3393 3405 hemophilia B E102 Disease_disorder:T150 R73 MODIFY Arg1:T149 Arg2:E102 T151 Disease_disorder 3457 3467 hemophilia E103 Disease_disorder:T151 A9 POLARITY E103 UNCERTAIN T152 Diagnostic_procedure 3473 3498 blood coagulation factors E104 Diagnostic_procedure:T152 T153 Diagnostic_procedure 3533 3551 factor IX activity E105 Diagnostic_procedure:T153 T154 Lab_value 3556 3558 3% E106 Lab_value:T154 R74 MODIFY Arg1:E106 Arg2:E105 R75 SUB_PROCEDURE Arg1:E105 Arg2:E104 T155 Disease_disorder 3613 3625 hemophilia B E107 Disease_disorder:T155 T156 Severity 3604 3612 moderate R76 MODIFY Arg1:T156 Arg2:E107 T157 Disease_disorder 3672 3675 DAH E108 Disease_disorder:T157 A10 POLARITY E108 NEG T158 Medication 3706 3728 corticosteroid therapy E109 Medication:T158 T159 Medication 3780 3792 prednisolone E110 Medication:T159 T160 Medication 3808 3849 coagulation factor IX replacement therapy E111 Medication:T160 A11 POLARITY E111 NEG T161 Disease_disorder 3868 3871 DAH E112 Disease_disorder:T161 A12 POLARITY E112 NEG T162 Sign_symptom 3875 3895 hemorrhagic symptoms E113 Sign_symptom:T162 A13 POLARITY E113 NEG T163 Duration 3915 3929 during 3 years E114 Duration:T163 T164 Medication 3972 3984 prednisolone E115 Medication:T164 A14 POLARITY E115 NEG * OVERLAP E1 E2 E3 E4 E5 E7 E9 E10 E11 E15 E18 E19 E23 E116 E22 R77 MODIFY Arg1:T7 Arg2:E4 R78 MODIFY Arg1:T8 Arg2:E5 R79 MODIFY Arg1:E13 Arg2:E11 T165 Date 661 673 at that time E116 Date:T165 R80 AFTER Arg1:E22 Arg2:E21 R81 BEFORE Arg1:E21 Arg2:E24 R82 BEFORE Arg1:E24 Arg2:E25 * OVERLAP E25 E26 R83 BEFORE Arg1:E26 Arg2:E27 R84 MODIFY Arg1:E28 Arg2:E27 R85 BEFORE Arg1:E27 Arg2:E29 R86 BEFORE Arg1:E29 Arg2:E30 * OVERLAP E30 E31 E32 R87 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 R88 AFTER Arg1:E34 Arg2:E35 R89 BEFORE Arg1:E35 Arg2:E36 * OVERLAP E36 E37 E38 R90 BEFORE Arg1:E38 Arg2:E39 R91 BEFORE Arg1:E39 Arg2:E40 R92 BEFORE Arg1:E40 Arg2:E41 * OVERLAP E41 E42 E43 R93 BEFORE Arg1:E43 Arg2:E45 R94 BEFORE Arg1:E45 Arg2:E46 * OVERLAP E46 E47 E48 E50 E52 E61 E62 E63 E64 E65 E66 E67 E68 E69 E70 R95 AFTER Arg1:E70 Arg2:E72 R96 BEFORE Arg1:E72 Arg2:E78 R97 BEFORE Arg1:E78 Arg2:E74 * OVERLAP E74 E79 E85 E84 E86 E88 R98 SUB_PROCEDURE Arg1:E80 Arg2:E79 R99 SUB_PROCEDURE Arg1:E81 Arg2:E79 R100 MODIFY Arg1:E90 Arg2:E89 R101 BEFORE Arg1:E88 Arg2:E89 R102 BEFORE Arg1:E89 Arg2:E91 R103 BEFORE Arg1:E91 Arg2:E93 R104 AFTER Arg1:E93 Arg2:E95 * OVERLAP E95 E96 E97 E98 E99 E101 E100 E102 R105 BEFORE Arg1:E102 Arg2:E103 * OVERLAP E103 E104 R106 BEFORE Arg1:E104 Arg2:E107 * OVERLAP E107 E108 E109 R107 BEFORE Arg1:E109 Arg2:E110 * OVERLAP E110 E111 R108 BEFORE Arg1:E111 Arg2:E112 * OVERLAP E112 E113 R109 MODIFY Arg1:E114 Arg2:E113 R110 MODIFY Arg1:E114 Arg2:E112 R111 AFTER Arg1:E113 Arg2:E115