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T1 Age 2 13 37-year-old T2 Personal_background 14 30 African American T3 Sex 31 37 female T4 Disease_disorder 90 101 sarcoidosis E1 Disease_disorder:T4 T5 History 82 101 stage 1 sarcoidosis T6 Lab_value 82 89 stage 1 R1 MODIFY Arg1:T6 Arg2:E1 T7 Clinical_event 102 111 presented E2 Clinical_event:T7 T8 Nonbiological_location 119 127 facility R2 MODIFY Arg1:T8 Arg2:E2 T9 Sign_symptom 154 173 shortness of breath E3 Sign_symptom:T9 T10 Date 175 190 Ten years prior E4 Date:T10 T11 Clinical_event 196 205 presented E5 Clinical_event:T11 T12 Disease_disorder 221 228 uveitis E6 Disease_disorder:T12 T13 Detailed_description 211 220 bilateral R3 MODIFY Arg1:T13 Arg2:E6 T14 Sign_symptom 233 245 lupus pernio E7 Sign_symptom:T14 T15 Sign_symptom 247 249 LP E8 Sign_symptom:T15 R4 IDENTICAL Arg1:E8 Arg2:E7 T16 Biological_structure 258 267 right ear R5 MODIFY Arg1:T16 Arg2:E7 T17 Disease_disorder 304 315 sarcoidosis E9 Disease_disorder:T17 T18 Therapeutic_procedure 338 345 treated E10 Therapeutic_procedure:T18 T19 Lab_value 325 337 successfully R6 MODIFY Arg1:T19 Arg2:E10 T20 Disease_disorder 375 386 sarcoidosis E11 Disease_disorder:T20 T21 Lab_value 396 405 quiescent R7 MODIFY Arg1:T21 Arg2:E11 T22 Date 412 427 three years ago E12 Date:T22 T23 Nonbiological_location 441 460 outside institution T24 Clinical_event 470 480 discovered E13 Clinical_event:T24 R8 MODIFY Arg1:T23 Arg2:E13 T25 Sign_symptom 499 510 involvement E14 Sign_symptom:T25 T26 Biological_structure 489 498 laryngeal R9 MODIFY Arg1:T26 Arg2:E14 T27 Therapeutic_procedure 520 527 treated E15 Therapeutic_procedure:T27 T28 Medication 533 543 prednisone E16 Medication:T28 T29 Dosage 544 555 60 mg daily R10 MODIFY Arg1:T29 Arg2:E16 R11 SUB_PROCEDURE Arg1:E16 Arg2:E15 T30 Duration 560 574 several months E17 Duration:T30 R12 MODIFY Arg1:E17 Arg2:E16 T31 Dosage 601 612 10 mg daily R13 MODIFY Arg1:T31 Arg2:E16 T32 Date 579 589 eventually E18 Date:T32 R14 MODIFY Arg1:E18 Arg2:T31 T33 Disease_disorder 618 629 sarcoidosis E19 Disease_disorder:T33 T34 Lab_value 639 654 well-controlled R15 MODIFY Arg1:T34 Arg2:E19 T35 Medication 683 693 prednisone E20 Medication:T35 T36 Date 700 716 six months prior E21 Date:T36 T37 Medication 758 768 prednisone E22 Medication:T37 A1 POLARITY E22 NEG T38 Lab_value 736 753 self-discontinued R16 MODIFY Arg1:T38 Arg2:E22 T39 Medication 807 827 Nopalea cactus juice E23 Medication:T39 T40 Therapeutic_procedure 785 806 homeopathic treatment E24 Therapeutic_procedure:T40 R17 SUB_PROCEDURE Arg1:E23 Arg2:E24 T41 Sign_symptom 929 936 dyspnea E25 Sign_symptom:T41 T42 Detailed_description 937 948 on exertion R18 MODIFY Arg1:T42 Arg2:E25 T43 Sign_symptom 964 971 dyspnea E26 Sign_symptom:T43 T44 Detailed_description 972 979 at rest R19 MODIFY Arg1:T44 Arg2:E26 T47 Sign_symptom 1076 1097 difficulty swallowing E28 Sign_symptom:T47 T48 Frequency 1055 1063 frequent R21 MODIFY Arg1:T48 Arg2:E28 T49 Nonbiological_location 1106 1126 emergency department T50 Diagnostic_procedure 1132 1152 physical examination E29 Diagnostic_procedure:T50 R22 MODIFY Arg1:T49 Arg2:E29 T51 Sign_symptom 1172 1192 respiratory distress E30 Sign_symptom:T51 T52 Sign_symptom 1215 1234 inspiratory stridor E31 Sign_symptom:T52 T53 Sign_symptom 1239 1249 hoarseness E32 Sign_symptom:T53 T54 Sign_symptom 1293 1300 lesions E33 Sign_symptom:T54 T55 Lab_value 1283 1292 indurated T56 Lab_value 1264 1281 chronic-appearing R23 MODIFY Arg1:T56 Arg2:E33 R24 MODIFY Arg1:T55 Arg2:E33 T57 Biological_structure 1308 1317 right ear R25 MODIFY Arg1:T57 Arg2:E33 T58 Disease_disorder 1347 1367 upper airway disease E34 Disease_disorder:T58 A2 POLARITY E34 MAYBE_POS T59 Diagnostic_procedure 1423 1435 laryngoscopy E35 Diagnostic_procedure:T59 T60 Detailed_description 1415 1422 bedside T61 Detailed_description 1406 1414 emergent R26 MODIFY Arg1:T60 Arg2:E35 R27 MODIFY Arg1:T61 Arg2:E35 T62 Disease_disorder 1382 1401 respiratory failure E36 Disease_disorder:T62 A3 POLARITY E36 UNCERTAIN T63 Lab_value 1372 1381 impending R28 MODIFY Arg1:T63 Arg2:E36 T64 Disease_disorder 1464 1474 obstructed E37 Disease_disorder:T64 T65 Biological_structure 1475 1481 airway R29 MODIFY Arg1:T65 Arg2:E37 T45 Sign_symptom 1028 1034 hoarse E27 Sign_symptom:T45 A4 TREND E27 INC T46 Activity 1002 1007 voice E38 Activity:T46 R20 MODIFY Arg1:E27 Arg2:E38 T66 Sign_symptom 1502 1513 retroflexed E39 Sign_symptom:T66 T67 Biological_structure 1491 1501 epiglottis R30 MODIFY Arg1:T67 Arg2:E39 T68 Biological_structure 1523 1530 glottis R31 MODIFY Arg1:T68 Arg2:E39 T69 Sign_symptom 1547 1552 edema E40 Sign_symptom:T69 T70 Lab_value 1535 1546 significant R32 MODIFY Arg1:T70 Arg2:E40 T71 Biological_structure 1560 1570 arytenoids T72 Biological_structure 1575 1594 aryepiglottic folds R33 MODIFY Arg1:T71 Arg2:E40 R34 MODIFY Arg1:T72 Arg2:E40 T73 Medication 1651 1664 dexamethasone E41 Medication:T73 T74 Administration 1639 1650 intravenous T75 Dosage 1629 1638 high-dose R35 MODIFY Arg1:T74 Arg2:E41 R36 MODIFY Arg1:T75 Arg2:E41 T76 Clinical_event 1669 1674 taken E42 Clinical_event:T76 T77 Nonbiological_location 1693 1707 operating room R37 MODIFY Arg1:T77 Arg2:E42 T78 Nonbiological_location 1709 1711 OR R38 IDENTICAL Arg1:T78 Arg2:T77 T79 Disease_disorder 1772 1783 obstruction E43 Disease_disorder:T79 T80 Biological_structure 1759 1771 upper airway T81 Lab_value 1750 1758 complete R39 MODIFY Arg1:T81 Arg2:E43 R40 MODIFY Arg1:T80 Arg2:E43 T82 Therapeutic_procedure 1716 1722 secure E44 Therapeutic_procedure:T82 T83 Biological_structure 1727 1733 airway R41 MODIFY Arg1:T83 Arg2:E44 T84 Diagnostic_procedure 1810 1830 direct visualization E45 Diagnostic_procedure:T84 T85 Biological_structure 1838 1844 larynx R42 MODIFY Arg1:T85 Arg2:E45 T86 Nonbiological_location 1852 1854 OR R43 MODIFY Arg1:T86 Arg2:E45 T87 Therapeutic_procedure 1864 1873 intubated E46 Therapeutic_procedure:T87 T88 Therapeutic_procedure 1880 1895 surgical airway E47 Therapeutic_procedure:T88 R44 SUB_PROCEDURE Arg1:E46 Arg2:E47 T89 Diagnostic_procedure 1914 1922 biopsies E48 Diagnostic_procedure:T89 T90 Biological_structure 1955 1965 epiglottis R45 MODIFY Arg1:T90 Arg2:E48 T91 Biological_structure 1932 1947 lingual surface R46 MODIFY Arg1:T91 Arg2:T90 T92 Therapeutic_procedure 1987 1999 tracheostomy E49 Therapeutic_procedure:T92 T93 Detailed_description 1979 1985 Shiley T94 Detailed_description 1969 1978 #4 cuffed R47 MODIFY Arg1:T93 Arg2:E49 R48 MODIFY Arg1:T94 Arg2:E49 T95 Diagnostic_procedure 2016 2034 respiratory status E50 Diagnostic_procedure:T95 T96 Lab_value 2047 2057 stabilized R49 MODIFY Arg1:T96 Arg2:E50 T97 Therapeutic_procedure 2063 2072 extubated E51 Therapeutic_procedure:T97 T98 Clinical_event 2078 2089 transferred E52 Clinical_event:T98 T99 Nonbiological_location 2097 2124 medical intensive care unit R50 MODIFY Arg1:T99 Arg2:E52 T100 Therapeutic_procedure 2130 2142 tracheostomy E53 Therapeutic_procedure:T100 T101 Detailed_description 2174 2180 Shiley T102 Detailed_description 2162 2173 #4 cuffless R51 MODIFY Arg1:T102 Arg2:E53 R52 MODIFY Arg1:T101 Arg2:E53 T103 Date 2198 2203 day 5 E54 Date:T103 T104 Medication 2260 2273 dexamethasone E55 Medication:T104 A5 POLARITY E55 NEG T105 Medication 2277 2287 prednisone E56 Medication:T105 T106 Dosage 2288 2299 60 mg daily R53 MODIFY Arg1:T106 Arg2:E56 T107 Administration 2248 2259 intravenous R54 MODIFY Arg1:T107 Arg2:E55 T108 Diagnostic_procedure 2301 2309 Biopsies E57 Diagnostic_procedure:T108 T109 Sign_symptom 2358 2368 granulomas E58 Sign_symptom:T109 T110 Disease_disorder 2385 2396 sarcoidosis E59 Disease_disorder:T110 T111 Detailed_description 2346 2357 epithelioid T112 Detailed_description 2330 2345 non-necrotizing R55 MODIFY Arg1:T111 Arg2:E58 R56 MODIFY Arg1:T112 Arg2:E58 T113 Dosage 2433 2442 high-dose T114 Medication 2443 2453 prednisone E60 Medication:T114 T115 Duration 2458 2470 three months E61 Duration:T115 T116 Clinical_event 2538 2548 discharged E62 Clinical_event:T116 T117 Nonbiological_location 2549 2553 home R57 MODIFY Arg1:T117 Arg2:E62 T118 Therapeutic_procedure 2506 2528 self-tracheostomy care E63 Therapeutic_procedure:T118 T119 Clinical_event 2492 2501 education E64 Clinical_event:T119 R58 MODIFY Arg1:E63 Arg2:E64 T120 Date 2573 2582 one-month E65 Date:T120 T121 Date 2587 2598 three-month E66 Date:T121 T122 Clinical_event 2599 2608 follow-up E67 Clinical_event:T122 T123 Sign_symptom 2640 2658 respiratory issues E68 Sign_symptom:T123 A6 POLARITY E68 NEG T124 Diagnostic_procedure 2667 2681 laryngoscopies E69 Diagnostic_procedure:T124 T125 Lab_value 2701 2712 improvement R59 MODIFY Arg1:T125 Arg2:E69 T126 Sign_symptom 2720 2725 edema E70 Sign_symptom:T126 A7 POLARITY E70 MAYBE_NEG T127 Biological_structure 2733 2743 arytenoids R60 MODIFY Arg1:T127 Arg2:E70 T128 Biological_structure 2748 2767 aryepiglottic folds R61 MODIFY Arg1:T128 Arg2:E70 T129 Disease_disorder 2801 2808 obscure E71 Disease_disorder:T129 T130 Biological_structure 2777 2787 epiglottis R62 MODIFY Arg1:T130 Arg2:E71 T131 Biological_structure 2813 2820 glottis R63 MODIFY Arg1:T131 Arg2:E71 T132 Medication 2852 2862 prednisone E72 Medication:T132 T133 Dosage 2842 2851 high-dose R64 MODIFY Arg1:T133 Arg2:E72 T134 Medication 2864 2876 Methotrexate E73 Medication:T134 T135 Medication 2897 2907 prednisone E74 Medication:T135 T136 Dosage 2923 2934 10 mg daily R65 MODIFY Arg1:T136 Arg2:E74 T137 Medication 2973 2983 prednisone E75 Medication:T137 T138 Dosage 3008 3019 20 mg daily R66 MODIFY Arg1:T138 Arg2:E75 T139 Therapeutic_procedure 3058 3076 surgical treatment E76 Therapeutic_procedure:T139 A8 POLARITY E76 NEG T140 Therapeutic_procedure 3125 3150 immunosuppressive therapy E77 Therapeutic_procedure:T140 T141 Therapeutic_procedure 3101 3119 medical management E78 Therapeutic_procedure:T141 R67 SUB_PROCEDURE Arg1:E77 Arg2:E78 R68 BEFORE Arg1:E1 Arg2:E2 * OVERLAP E2 E3 R69 AFTER Arg1:E3 Arg2:E4 * OVERLAP E4 E5 E6 E7 E9 R70 BEFORE Arg1:E9 Arg2:E10 * OVERLAP E10 E11 R71 BEFORE Arg1:E11 Arg2:E12 * OVERLAP E12 E13 E14 R72 BEFORE Arg1:E14 Arg2:E15 * OVERLAP E15 E17 E18 R73 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 T142 Dosage 663 679 maintenance dose R74 MODIFY Arg1:T142 Arg2:E20 R75 BEFORE Arg1:E20 Arg2:E21 * OVERLAP E21 E22 E24 R76 BEFORE Arg1:E24 Arg2:E25 R77 BEFORE Arg1:E25 Arg2:E26 * OVERLAP E26 E38 E27 E28 R78 BEFORE Arg1:E28 Arg2:E29 * OVERLAP E29 E30 E31 E32 E33 E34 E36 E35 E37 E39 E40 R79 BEFORE Arg1:E40 Arg2:E41 R80 BEFORE Arg1:E41 Arg2:E42 * OVERLAP E42 E44 E43 E45 E46 E48 E49 R81 BEFORE Arg1:E49 Arg2:E50 * OVERLAP E50 E51 R82 BEFORE Arg1:E51 Arg2:E52 R83 BEFORE Arg1:E52 Arg2:E53 * OVERLAP E53 E54 E55 E56 R84 BEFORE Arg1:E56 Arg2:E57 * OVERLAP E57 E58 E59 R85 BEFORE Arg1:E59 Arg2:E60 R86 MODIFY Arg1:T113 Arg2:E60 * OVERLAP E60 E61 R87 BEFORE Arg1:E61 Arg2:E64 R88 BEFORE Arg1:E64 Arg2:E62 R89 BEFORE Arg1:E62 Arg2:E65 R90 MODIFY Arg1:E65 Arg2:E67 R91 MODIFY Arg1:E66 Arg2:E67 R92 BEFORE Arg1:E65 Arg2:E66 * OVERLAP E66 E68 E69 E70 E71 E72 R93 BEFORE Arg1:E72 Arg2:E73 * OVERLAP E73 E74 R94 BEFORE Arg1:E74 Arg2:E75 R95 BEFORE Arg1:E75 Arg2:E76 * OVERLAP E76 E78