Downloads: 1
458 lines (457 with data), 14.8 kB
T1 Age 2 13 23-year-old T2 Sex 14 17 man T3 Disease_disorder 36 58 severe aplastic anemia E1 Disease_disorder:T3 T4 Disease_disorder 60 63 SAA E2 Disease_disorder:T4 R1 IDENTICAL Arg1:E2 Arg2:E1 T5 History 36 58 severe aplastic anemia T6 Date 141 153 January 2014 E3 Date:T6 T7 Subject 131 137 mother T8 Therapeutic_procedure 75 102 bone marrow transplantation E4 Therapeutic_procedure:T8 T9 Detailed_description 112 130 HLA-haploidentical R2 MODIFY Arg1:T9 Arg2:T7 T10 Medication 194 220 busulphan cyclophosphamide E5 Medication:T10 T11 Medication 225 247 antithymocyte globulin E6 Medication:T11 T12 Medication 265 279 Cyclosporine A E7 Medication:T12 T13 Medication 301 313 methotrexate E8 Medication:T13 T14 Detailed_description 290 300 short-term R3 MODIFY Arg1:T14 Arg2:E8 T15 Medication 315 318 MTX E9 Medication:T15 T16 Medication 281 284 CsA E10 Medication:T16 R4 IDENTICAL Arg1:E9 Arg2:E8 R5 IDENTICAL Arg1:E10 Arg2:E7 T17 Medication 249 253 BUCY E11 Medication:T17 T18 Medication 254 257 ATG E12 Medication:T18 R6 IDENTICAL Arg1:E11 Arg2:E5 R7 IDENTICAL Arg1:E12 Arg2:E6 T19 Medication 325 346 mycophenolate mofetil E13 Medication:T19 T20 Medication 348 351 MMF E14 Medication:T20 R8 IDENTICAL Arg1:E14 Arg2:E13 T21 Disease_disorder 386 411 graft-versus-host disease E15 Disease_disorder:T21 A1 POLARITY E15 UNCERTAIN T22 Disease_disorder 413 417 GVHD E16 Disease_disorder:T22 R9 IDENTICAL Arg1:E16 Arg2:E15 T23 Disease_disorder 478 502 infectious complications E17 Disease_disorder:T23 A2 POLARITY E17 UNCERTAIN T24 Medication 519 530 fluconazole E18 Medication:T24 T25 Therapeutic_procedure 546 557 prophylaxis E19 Therapeutic_procedure:T25 T26 Detailed_description 535 545 antifungal R10 MODIFY Arg1:T26 Arg2:E19 R11 SUB_PROCEDURE Arg1:E18 Arg2:E19 T27 Medication 562 571 acyclovir E20 Medication:T27 T28 Disease_disorder 598 608 infections E21 Disease_disorder:T28 T29 Detailed_description 583 597 herpes-related R12 MODIFY Arg1:T29 Arg2:E21 A3 POLARITY E21 UNCERTAIN T30 Diagnostic_procedure 612 620 hemogram E22 Diagnostic_procedure:T30 T31 Disease_disorder 751 755 GVHD E23 Disease_disorder:T31 T32 Detailed_description 745 750 acute R13 MODIFY Arg1:T32 Arg2:E23 T33 Detailed_description 736 744 grade II R14 MODIFY Arg1:T33 Arg2:E23 R15 MODIFY Arg1:T7 Arg2:E4 T34 Diagnostic_procedure 666 669 ANC E24 Diagnostic_procedure:T34 T35 Clinical_event 3642 3650 followed E25 Clinical_event:T35 T36 Disease_disorder 3705 3714 infection E26 Disease_disorder:T36 A4 POLARITY E26 NEG T37 Detailed_description 3698 3704 fungal T38 Detailed_description 3689 3697 invasive R16 MODIFY Arg1:T37 Arg2:E26 R17 MODIFY Arg1:T38 Arg2:E26 T39 Lab_value 669 679 >0.5×109/L E27 Lab_value:T39 R18 MODIFY Arg1:E27 Arg2:E24 T40 Date 684 691 day +12 E28 Date:T40 T41 Therapeutic_procedure 697 712 transplantation E29 Therapeutic_procedure:T41 T42 Sign_symptom 634 664 reconstruction of granulocytes E30 Sign_symptom:T42 R19 SUB_PROCEDURE Arg1:E24 Arg2:E22 T43 Biological_structure 763 767 skin R20 MODIFY Arg1:T43 Arg2:E23 T44 Date 771 778 day +42 E31 Date:T44 T45 Therapeutic_procedure 784 799 transplantation E32 Therapeutic_procedure:T45 T46 Medication 855 874 methyl-prednisolone E33 Medication:T46 T47 Sign_symptom 893 910 complete response E34 Sign_symptom:T47 T48 Sign_symptom 912 914 CR E35 Sign_symptom:T48 R21 IDENTICAL Arg1:E35 Arg2:E34 T49 Dosage 838 851 standard-dose R22 MODIFY Arg1:T49 Arg2:E33 T50 Disease_disorder 931 943 chronic GVHD E36 Disease_disorder:T50 T51 Disease_disorder 945 950 cGVHD E37 Disease_disorder:T51 R23 IDENTICAL Arg1:E37 Arg2:E36 T52 Biological_structure 959 963 skin R24 MODIFY Arg1:T52 Arg2:E36 T53 Date 990 998 day +100 E38 Date:T53 T54 Therapeutic_procedure 1004 1019 transplantation E39 Therapeutic_procedure:T54 T55 Medication 1044 1056 prednisolone E40 Medication:T55 T56 Medication 1061 1064 CsA E41 Medication:T56 #1 AnnotatorNotes E41 Cyclosporin A T57 Date 1069 1076 day 120 E42 Date:T57 T58 Therapeutic_procedure 1082 1097 transplantation E43 Therapeutic_procedure:T58 T59 Sign_symptom 1118 1123 cough E44 Sign_symptom:T59 T60 Medication 1128 1139 antibiotics E45 Medication:T60 T61 Diagnostic_procedure 1161 1175 blood analysis E46 Diagnostic_procedure:T61 T62 Diagnostic_procedure 1200 1203 WBC E47 Diagnostic_procedure:T62 T63 Diagnostic_procedure 1217 1220 ANC E48 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1234 1244 hemoglobin E49 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1258 1267 platelets E50 Diagnostic_procedure:T65 T66 Lab_value 1205 1215 2.34×109/L E51 Lab_value:T66 T67 Lab_value 1222 1232 1.72×109/L E52 Lab_value:T67 T68 Lab_value 1246 1252 85 g/L E53 Lab_value:T68 T69 Lab_value 1269 1277 72×109/L E54 Lab_value:T69 R25 MODIFY Arg1:E51 Arg2:E47 R26 MODIFY Arg1:E52 Arg2:E48 R27 MODIFY Arg1:E53 Arg2:E49 R28 MODIFY Arg1:E54 Arg2:E50 R29 SUB_PROCEDURE Arg1:E47 Arg2:E46 R30 SUB_PROCEDURE Arg1:E48 Arg2:E46 R31 SUB_PROCEDURE Arg1:E49 Arg2:E46 R32 SUB_PROCEDURE Arg1:E50 Arg2:E46 T70 Diagnostic_procedure 1301 1320 computed tomography E55 Diagnostic_procedure:T70 T71 Diagnostic_procedure 1322 1324 CT E56 Diagnostic_procedure:T71 T72 Biological_structure 1295 1300 chest R33 MODIFY Arg1:T72 Arg2:E55 R34 IDENTICAL Arg1:E56 Arg2:E55 T73 Diagnostic_procedure 1335 1354 tests for pathogens E57 Diagnostic_procedure:T73 T74 Detailed_description 1355 1376 via routine culturing R35 MODIFY Arg1:T74 Arg2:E57 T75 Diagnostic_procedure 1404 1417 Beta-D glucan E58 Diagnostic_procedure:T75 T76 Diagnostic_procedure 1419 1425 G-test E59 Diagnostic_procedure:T76 R36 IDENTICAL Arg1:E59 Arg2:E58 T77 Diagnostic_procedure 1431 1444 Galactomannan E60 Diagnostic_procedure:T77 T78 Diagnostic_procedure 1446 1453 GM-test E61 Diagnostic_procedure:T78 R37 IDENTICAL Arg1:E61 Arg2:E60 T79 Lab_value 1464 1472 negative E62 Lab_value:T79 T80 Detailed_description 1388 1393 blood R38 MODIFY Arg1:T80 Arg2:E58 R39 MODIFY Arg1:T80 Arg2:E60 R40 MODIFY Arg1:E62 Arg2:E60 R41 MODIFY Arg1:E62 Arg2:E58 T81 Sign_symptom 1488 1493 cough E63 Sign_symptom:T81 A5 TREND E63 STAY T82 Medication 1513 1524 antibiotics E64 Medication:T82 T83 Medication 1569 1581 voriconazole E65 Medication:T83 T84 Dosage 1583 1612 6 mg/kg/12h for the first day T85 Dosage 1626 1637 4 mg/kg/12h R42 MODIFY Arg1:T84 Arg2:E65 R43 MODIFY Arg1:T85 Arg2:E65 T86 Sign_symptom 1646 1654 toxicity E66 Sign_symptom:T86 T87 Biological_structure 1640 1645 Liver R44 MODIFY Arg1:T87 Arg2:E66 T88 Medication 1671 1683 voriconazole E67 Medication:T88 T89 Therapeutic_procedure 1704 1723 anti-fungal regimen E68 Therapeutic_procedure:T89 T90 Medication 1739 1749 micafungin E69 Medication:T90 R45 SUB_PROCEDURE Arg1:E69 Arg2:E68 T91 Dosage 1751 1759 100 mg/d R46 MODIFY Arg1:T91 Arg2:E69 T92 Sign_symptom 1786 1791 cough E70 Sign_symptom:T92 A6 TREND E70 STAY T93 Detailed_description 1775 1785 persistent R47 MODIFY Arg1:T93 Arg2:E70 T94 Sign_symptom 1812 1822 hoarseness E71 Sign_symptom:T94 T95 Date 1833 1848 after two weeks E72 Date:T95 T96 Sign_symptom 1864 1870 ulcers E73 Sign_symptom:T96 T97 Biological_structure 1897 1903 throat R48 MODIFY Arg1:T97 Arg2:E73 T98 Diagnostic_procedure 1907 1919 laryngoscopy E74 Diagnostic_procedure:T98 T99 Sign_symptom 1959 1966 dyspnea E75 Sign_symptom:T99 T100 Severity 1952 1958 severe R49 MODIFY Arg1:T100 Arg2:E75 T101 Date 1967 1988 in the following week E76 Date:T101 T102 Therapeutic_procedure 2021 2031 treatments E77 Therapeutic_procedure:T102 T103 Detailed_description 2013 2020 topical T104 Detailed_description 1994 2008 anti-infection R50 MODIFY Arg1:T103 Arg2:E77 R51 MODIFY Arg1:T104 Arg2:E77 T105 Diagnostic_procedure 2057 2069 bronchoscopy E78 Diagnostic_procedure:T105 T106 Detailed_description 2046 2056 Fiberoptic R52 MODIFY Arg1:T106 Arg2:E78 T107 Sign_symptom 2101 2109 material E79 Sign_symptom:T107 T108 Sign_symptom 2140 2150 obstructed E80 Sign_symptom:T108 T109 Detailed_description 2133 2139 nearly R53 MODIFY Arg1:T109 Arg2:E80 T110 Biological_structure 2155 2163 bronchus R54 MODIFY Arg1:T110 Arg2:E80 T111 Shape 2093 2100 nodular T112 Detailed_description 2082 2091 irregular R55 MODIFY Arg1:T111 Arg2:E79 R56 MODIFY Arg1:T112 Arg2:E79 T113 Detailed_description 2115 2125 white moss R57 MODIFY Arg1:T113 Arg2:E79 T114 Diagnostic_procedure 2180 2182 CT E81 Diagnostic_procedure:T114 T115 Biological_structure 2174 2179 chest R58 MODIFY Arg1:T115 Arg2:E81 T116 Lab_value 2195 2203 negative E82 Lab_value:T116 R59 MODIFY Arg1:E82 Arg2:E81 T117 Diagnostic_procedure 2224 2253 histopathological examination E83 Diagnostic_procedure:T117 T118 Diagnostic_procedure 2257 2263 biopsy E84 Diagnostic_procedure:T118 T119 Disease_disorder 2286 2297 Aspergillus E85 Disease_disorder:T119 T120 Disease_disorder 2376 2393 tracheobronchitis E86 Disease_disorder:T120 T121 Disease_disorder 2364 2375 Aspergillus E87 Disease_disorder:T121 T122 Detailed_description 2347 2363 pseudomembranous R60 CAUSE Arg1:E87 Arg2:E86 R61 MODIFY Arg1:T122 Arg2:E86 T123 Detailed_description 2394 2403 type ITBA R62 MODIFY Arg1:T123 Arg2:E86 T124 Diagnostic_procedure 2428 2440 bronchoscopy E88 Diagnostic_procedure:T124 T125 Diagnostic_procedure 2447 2471 pathological examination E89 Diagnostic_procedure:T125 T126 Medication 2482 2492 antibiotic E90 Medication:T126 T127 Medication 2497 2507 micafungin E91 Medication:T127 A7 POLARITY E90 NEG A8 POLARITY E91 NEG T128 Medication 2545 2559 amphotericin B E92 Medication:T128 T129 Detailed_description 2535 2544 liposomal R63 MODIFY Arg1:T129 Arg2:E92 T130 Medication 2571 2574 AmB E93 Medication:T130 T131 Detailed_description 2561 2570 liposomal R64 MODIFY Arg1:T131 Arg2:E93 R65 IDENTICAL Arg1:E93 Arg2:E92 T132 Dosage 2593 2598 daily T133 Dosage 2619 2626 3 mg/kg R66 MODIFY Arg1:T133 Arg2:E92 R67 MODIFY Arg1:T132 Arg2:E92 T134 Diagnostic_procedure 2648 2658 creatinine E94 Diagnostic_procedure:T134 T135 Detailed_description 2642 2647 serum R68 MODIFY Arg1:T135 Arg2:E94 T136 Lab_value 2675 2686 60.4 μmol/L E95 Lab_value:T136 T137 Lab_value 2665 2669 rose E96 Lab_value:T137 T138 Lab_value 2690 2700 168 μmol/L E97 Lab_value:T138 R69 MODIFY Arg1:E96 Arg2:E94 R70 MODIFY Arg1:E95 Arg2:E94 R71 MODIFY Arg1:E97 Arg2:E94 T139 Date 2701 2724 during the first 7 days E98 Date:T139 T140 Medication 2738 2741 AmB E99 Medication:T140 T141 Detailed_description 2728 2737 liposomal R72 MODIFY Arg1:T141 Arg2:E99 T142 Disease_disorder 2772 2789 renal dysfunction E100 Disease_disorder:T142 T143 Severity 2760 2771 progressive R73 MODIFY Arg1:T143 Arg2:E100 T144 Medication 2795 2806 anti-fungal E101 Medication:T144 T145 Medication 2848 2860 posaconazole E102 Medication:T145 T146 Medication 2879 2890 caspofungin E103 Medication:T146 R74 SUB_PROCEDURE Arg1:E102 Arg2:E101 R75 SUB_PROCEDURE Arg1:E103 Arg2:E101 T147 Dosage 2862 2873 400 mg/12 h T148 Dosage 2892 2904 50 mg, daily T149 Dosage 2906 2930 70 mg for the first dose R76 MODIFY Arg1:T147 Arg2:E102 R77 MODIFY Arg1:T148 Arg2:E103 R78 MODIFY Arg1:T149 Arg2:E103 T150 Duration 2972 2979 2 weeks E104 Duration:T150 T151 Medication 2938 2957 combination therapy E105 Medication:T151 R79 SUB_PROCEDURE Arg1:E102 Arg2:E105 R80 SUB_PROCEDURE Arg1:E103 Arg2:E105 T152 Sign_symptom 3000 3007 nodules E106 Sign_symptom:T152 A9 POLARITY E106 NEG T153 Biological_structure 3015 3021 throat R81 MODIFY Arg1:T153 Arg2:E106 T154 Diagnostic_procedure 3051 3063 bronchoscopy E107 Diagnostic_procedure:T154 T155 Diagnostic_procedure 3098 3100 CT E108 Diagnostic_procedure:T155 T156 Biological_structure 3092 3097 chest R82 MODIFY Arg1:T156 Arg2:E108 T157 Sign_symptom 3113 3124 progression E109 Sign_symptom:T157 T158 Sign_symptom 3150 3157 dyspnea E110 Sign_symptom:T158 A10 TREND E110 INC T159 Diagnostic_procedure 3196 3208 bronchoscopy E111 Diagnostic_procedure:T159 T160 Detailed_description 3185 3195 fiberoptic R83 MODIFY Arg1:T160 Arg2:E111 T161 Therapeutic_procedure 3226 3232 remove E112 Therapeutic_procedure:T161 T162 Sign_symptom 3237 3257 obstructive material E113 Sign_symptom:T162 T163 Biological_structure 3277 3284 airways R84 MODIFY Arg1:T163 Arg2:E113 T164 Frequency 3285 3296 once a week R85 MODIFY Arg1:T164 Arg2:E112 R86 MODIFY Arg1:E113 Arg2:E112 T165 Duration 3301 3310 two weeks E114 Duration:T165 T166 Sign_symptom 3323 3331 symptoms E115 Sign_symptom:T166 A11 POLARITY E115 NEG T167 Biological_structure 3360 3365 chest T168 Diagnostic_procedure 3366 3368 CT E116 Diagnostic_procedure:T168 R87 MODIFY Arg1:T167 Arg2:E116 T169 Lab_value 3381 3389 negative E117 Lab_value:T169 R88 MODIFY Arg1:E117 Arg2:E116 T170 Medication 3428 3439 anti-fungal E118 Medication:T170 A12 POLARITY E118 NEG T171 Diagnostic_procedure 3464 3469 tests E119 Diagnostic_procedure:T171 T172 Disease_disorder 3488 3499 Aspergillus E120 Disease_disorder:T172 A13 POLARITY E120 NEG T173 Medication 3501 3513 Posaconazole E121 Medication:T173 T174 Therapeutic_procedure 3546 3568 prophylactic treatment E122 Therapeutic_procedure:T174 R89 SUB_PROCEDURE Arg1:E121 Arg2:E122 T175 Clinical_event 3589 3599 discharged E123 Clinical_event:T175 T176 Nonbiological_location 3605 3613 hospital R90 MODIFY Arg1:T176 Arg2:E123 R91 BEFORE Arg1:E1 Arg2:E4 * OVERLAP E4 E3 R92 AFTER Arg1:E3 Arg2:E5 * OVERLAP E5 E6 R93 BEFORE Arg1:E6 Arg2:E7 * OVERLAP E7 E8 E13 E15 E17 E19 E20 E21 R94 BEFORE Arg1:E21 Arg2:E22 * OVERLAP E22 E30 E28 R95 AFTER Arg1:E28 Arg2:E29 R96 BEFORE Arg1:E29 Arg2:E23 * OVERLAP E23 E31 R97 AFTER Arg1:E31 Arg2:E32 R98 BEFORE Arg1:E32 Arg2:E33 R99 BEFORE Arg1:E33 Arg2:E34 R100 BEFORE Arg1:E34 Arg2:E36 * OVERLAP E36 E38 R101 AFTER Arg1:E38 Arg2:E39 R102 BEFORE Arg1:E39 Arg2:E40 * OVERLAP E40 E41 R103 BEFORE Arg1:E41 Arg2:E42 R104 AFTER Arg1:E42 Arg2:E43 R105 BEFORE Arg1:E43 Arg2:E44 R106 BEFORE Arg1:E44 Arg2:E45 * OVERLAP E45 E46 E55 E57 E58 E60 E63 E64 R107 BEFORE Arg1:E64 Arg2:E65 R108 BEFORE Arg1:E65 Arg2:E66 * OVERLAP E66 E67 R109 BEFORE Arg1:E67 Arg2:E68 R110 BEFORE Arg1:E68 Arg2:E70 * OVERLAP E70 E71 E72 E73 E74 R111 BEFORE Arg1:E74 Arg2:E75 * OVERLAP E75 E76 E77 E78 E79 E80 E81 E83 E84 E85 E87 E86 E88 E89 R112 BEFORE Arg1:E89 Arg2:E90 * OVERLAP E90 E91 E92 R113 BEFORE Arg1:E92 Arg2:E94 * OVERLAP E94 E98 E99 R114 BEFORE Arg1:E99 Arg2:E100 * OVERLAP E100 E101 R115 BEFORE Arg1:E101 Arg2:E105 * OVERLAP E105 E104 R116 BEFORE Arg1:E104 Arg2:E106 * OVERLAP E106 E107 E108 E109 R117 BEFORE Arg1:E109 Arg2:E110 * OVERLAP E110 E111 E112 E113 E114 R118 BEFORE Arg1:E114 Arg2:E115 * OVERLAP E115 E116 R119 BEFORE Arg1:E116 Arg2:E118 T177 Lab_value 3475 3483 negative E124 Lab_value:T177 * OVERLAP E118 E119 E120 E121 R120 MODIFY Arg1:E124 Arg2:E119 R121 BEFORE Arg1:E121 Arg2:E123 R122 BEFORE Arg1:E123 Arg2:E25 * OVERLAP E25 E26