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T1 Age 2 13 39-year-old T2 Personal_background 14 20 Korean T3 Sex 21 25 male T4 Clinical_event 26 30 come E1 Clinical_event:T4 T5 Nonbiological_location 38 46 hospital R1 MODIFY Arg1:T5 Arg2:E1 T6 Sign_symptom 62 67 cough E2 Sign_symptom:T6 T7 Sign_symptom 69 76 myalgia E3 Sign_symptom:T7 T8 Sign_symptom 82 87 fever E4 Sign_symptom:T8 T9 Duration 97 114 lasted for 5 days E5 Duration:T9 T10 Occupation 125 139 company worker T11 History 192 206 current smoker T12 History 144 181 denied any previous medical histories T13 Diagnostic_procedure 249 260 vital signs E6 Diagnostic_procedure:T13 T14 Diagnostic_procedure 267 281 blood pressure E7 Diagnostic_procedure:T14 T15 Lab_value 283 294 100/60 mmHg R2 MODIFY Arg1:T15 Arg2:E7 T16 Diagnostic_procedure 296 306 heart rate E8 Diagnostic_procedure:T16 T17 Lab_value 308 315 100/min R3 MODIFY Arg1:T17 Arg2:E8 T18 Diagnostic_procedure 317 333 respiratory rate E9 Diagnostic_procedure:T18 T19 Lab_value 335 349 25 breaths/min R4 MODIFY Arg1:T19 Arg2:E9 T20 Diagnostic_procedure 355 371 body temperature E10 Diagnostic_procedure:T20 T21 Lab_value 373 378 39 °C R5 MODIFY Arg1:T21 Arg2:E10 R6 SUB_PROCEDURE Arg1:E7 Arg2:E6 R7 SUB_PROCEDURE Arg1:E8 Arg2:E6 R8 SUB_PROCEDURE Arg1:E9 Arg2:E6 R9 SUB_PROCEDURE Arg1:E10 Arg2:E6 T22 Diagnostic_procedure 387 407 physical examination E11 Diagnostic_procedure:T22 T23 Diagnostic_procedure 419 434 breathing sound E12 Diagnostic_procedure:T23 T24 Lab_value 409 418 decreased R10 MODIFY Arg1:T24 Arg2:E12 T25 Biological_structure 452 468 right lower lung R11 MODIFY Arg1:T25 Arg2:E12 R12 SUB_PROCEDURE Arg1:E12 Arg2:E11 T26 Diagnostic_procedure 470 486 Laboratory tests E13 Diagnostic_procedure:T26 T27 Diagnostic_procedure 498 516 c-reactive protein E14 Diagnostic_procedure:T27 T28 Diagnostic_procedure 518 521 CRP E15 Diagnostic_procedure:T28 R13 IDENTICAL Arg1:E15 Arg2:E14 T29 Lab_value 532 541 119 mg/dL R14 MODIFY Arg1:T29 Arg2:E14 T30 Diagnostic_procedure 545 560 total bilirubin E16 Diagnostic_procedure:T30 T31 Lab_value 570 579 1.8 mg/dL R15 MODIFY Arg1:T31 Arg2:E16 T32 Diagnostic_procedure 585 605 alanine transaminase E17 Diagnostic_procedure:T32 T33 Diagnostic_procedure 610 632 aspartate transaminase E18 Diagnostic_procedure:T33 T34 Lab_value 643 646 250 R16 MODIFY Arg1:T34 Arg2:E17 T35 Lab_value 651 659 172 IU/L R17 MODIFY Arg1:T35 Arg2:E18 R18 SUB_PROCEDURE Arg1:E14 Arg2:E13 R19 SUB_PROCEDURE Arg1:E16 Arg2:E13 R20 SUB_PROCEDURE Arg1:E17 Arg2:E13 R21 SUB_PROCEDURE Arg1:E18 Arg2:E13 T36 Diagnostic_procedure 679 693 platelet count E19 Diagnostic_procedure:T36 T37 Lab_value 698 708 98,000/mm3 R22 MODIFY Arg1:T37 Arg2:E19 T38 Diagnostic_procedure 720 736 white cell count E20 Diagnostic_procedure:T38 T39 Lab_value 741 749 8150/mm3 T40 Lab_value 751 766 neutrophil: 85% R23 MODIFY Arg1:T39 Arg2:E20 R24 MODIFY Arg1:T40 Arg2:E20 T41 Diagnostic_procedure 776 803 arterial blood gas analysis E21 Diagnostic_procedure:T41 T42 Detailed_description 812 823 in room air R25 MODIFY Arg1:T42 Arg2:E21 T43 Diagnostic_procedure 825 827 pH E22 Diagnostic_procedure:T43 T44 Diagnostic_procedure 829 834 PaCO2 E23 Diagnostic_procedure:T44 T45 Diagnostic_procedure 836 840 PaO2 E24 Diagnostic_procedure:T45 T46 Diagnostic_procedure 842 853 bicarbonate E25 Diagnostic_procedure:T46 T47 Diagnostic_procedure 859 876 oxygen saturation E26 Diagnostic_procedure:T47 T48 Lab_value 889 893 7.50 R26 MODIFY Arg1:T48 Arg2:E22 T49 Lab_value 895 902 34 mmHg R27 MODIFY Arg1:T49 Arg2:E23 T50 Lab_value 904 911 67 mmHg R28 MODIFY Arg1:T50 Arg2:E24 T51 Lab_value 913 924 26.5 mmol/L R29 MODIFY Arg1:T51 Arg2:E25 T52 Lab_value 930 933 95% R30 MODIFY Arg1:T52 Arg2:E26 T53 Diagnostic_procedure 951 992 test for the human immunodeficiency virus E27 Diagnostic_procedure:T53 T54 Lab_value 997 1005 negative R31 MODIFY Arg1:T54 Arg2:E27 T56 Diagnostic_procedure 1032 1042 antibodies E29 Diagnostic_procedure:T56 T57 Lab_value 1048 1056 negative T55 Detailed_description 1022 1031 Chlamydia T59 Detailed_description 1007 1017 Mycoplasma R32 MODIFY Arg1:T55 Arg2:E29 R33 MODIFY Arg1:T59 Arg2:E29 R34 MODIFY Arg1:T57 Arg2:E29 T58 Diagnostic_procedure 1087 1103 urinary antigens E28 Diagnostic_procedure:T58 T60 Detailed_description 1076 1086 Legionella T61 Detailed_description 1058 1071 Streptococcal R35 MODIFY Arg1:T60 Arg2:E28 R36 MODIFY Arg1:T61 Arg2:E28 T62 Lab_value 1109 1117 negative R37 MODIFY Arg1:T62 Arg2:E28 T63 Diagnostic_procedure 1154 1176 cytoplasmic antibodies E30 Diagnostic_procedure:T63 T64 Detailed_description 1136 1153 anti-neutrophilic T65 Detailed_description 1119 1131 Anti-nuclear R38 MODIFY Arg1:T64 Arg2:E30 R39 MODIFY Arg1:T65 Arg2:E30 T66 Lab_value 1187 1195 negative R40 MODIFY Arg1:T66 Arg2:E30 T67 Diagnostic_procedure 1205 1210 X-ray E31 Diagnostic_procedure:T67 T68 Biological_structure 1199 1204 chest R41 MODIFY Arg1:T68 Arg2:E31 T69 Sign_symptom 1218 1231 consolidation E32 Sign_symptom:T69 T70 Biological_structure 1239 1269 right mid to lower lung fields R42 MODIFY Arg1:T70 Arg2:E32 T71 Diagnostic_procedure 1277 1296 computed tomography E33 Diagnostic_procedure:T71 T72 Biological_structure 1271 1276 Chest R43 MODIFY Arg1:T72 Arg2:E33 T73 Sign_symptom 1304 1317 consolidation E34 Sign_symptom:T73 T74 Texture 1323 1355 surrounding ground glass opacity R44 MODIFY Arg1:T74 Arg2:E34 T75 Biological_structure 1363 1380 right middle lobe R45 MODIFY Arg1:T75 Arg2:E34 T76 Disease_disorder 1404 1420 pleural effusion E35 Disease_disorder:T76 T77 Severity 1388 1400 small amount R46 MODIFY Arg1:T77 Arg2:E35 T78 Biological_structure 1428 1444 right hemithorax R47 MODIFY Arg1:T78 Arg2:E35 T79 Diagnostic_procedure 1464 1474 sonography E36 Diagnostic_procedure:T79 T80 Biological_structure 1454 1463 Abdominal R48 MODIFY Arg1:T80 Arg2:E36 T81 Biological_structure 1511 1531 hepatobiliary system T82 Lab_value 1484 1503 no abnormal finding R49 MODIFY Arg1:T82 Arg2:E36 R50 MODIFY Arg1:T81 Arg2:T82 T83 Medication 1567 1573 oxygen E37 Medication:T83 T84 Administration 1574 1581 nasally T85 Dosage 1556 1563 4 L/min R51 MODIFY Arg1:T84 Arg2:E37 R52 MODIFY Arg1:T85 Arg2:E37 T86 Medication 1596 1607 antibiotics E38 Medication:T86 T87 Medication 1630 1643 cephalosporin E39 Medication:T87 T88 Medication 1648 1657 macrolide E40 Medication:T88 R53 SUB_PROCEDURE Arg1:E39 Arg2:E38 R54 SUB_PROCEDURE Arg1:E40 Arg2:E38 T89 Disease_disorder 1702 1711 pneumonia E41 Disease_disorder:T89 T90 Detailed_description 1683 1701 community-acquired R55 MODIFY Arg1:T90 Arg2:E41 T91 Sign_symptom 1762 1767 fever E42 Sign_symptom:T91 A1 TREND E42 STAY T92 Sign_symptom 1803 1810 dyspnea E43 Sign_symptom:T92 T93 Date 1720 1730 second day E44 Date:T93 T94 Sign_symptom 1816 1825 hypoxemia E45 Sign_symptom:T94 A2 TREND E45 INC T95 Medication 1874 1880 oxygen E46 Medication:T95 T96 Administration 1887 1898 simple mask T97 Dosage 1863 1870 7 L/min R56 MODIFY Arg1:T97 Arg2:E46 R57 MODIFY Arg1:T96 Arg2:E46 T98 Sign_symptom 1907 1920 consolidation E47 Sign_symptom:T98 A3 TREND E47 INC T99 Disease_disorder 1925 1941 pleural effusion E48 Disease_disorder:T99 A4 TREND E48 INC T100 Therapeutic_procedure 2006 2019 thoracentesis E49 Therapeutic_procedure:T100 T101 Diagnostic_procedure 1989 2001 bronchoscopy E50 Diagnostic_procedure:T101 T102 Diagnostic_procedure 2031 2088 real-time reverse transcriptase polymerase chain reaction E51 Diagnostic_procedure:T102 T103 Diagnostic_procedure 2090 2096 RT-PCR E52 Diagnostic_procedure:T103 R58 IDENTICAL Arg1:E52 Arg2:E51 T104 Detailed_description 2021 2030 Multiplex R59 MODIFY Arg1:T104 Arg2:E51 T105 Detailed_description 2098 2121 for respiratory viruses R60 MODIFY Arg1:T105 Arg2:E51 T106 Detailed_description 2122 2156 using bronchoalveolar lavage fluid R61 MODIFY Arg1:T106 Arg2:E51 T108 Diagnostic_procedure 2203 2226 microbiological studies E54 Diagnostic_procedure:T108 T110 Disease_disorder 2355 2375 adenovirus pneumonia E56 Disease_disorder:T110 T107 Lab_value 2161 2190 positive for human adenovirus T109 Diagnostic_procedure 2242 2255 Pleural fluid E53 Diagnostic_procedure:T109 T111 Lab_value 2260 2287 lymphocyte-dominant exudate T112 Lab_value 2301 2330 positive for human adenovirus R62 MODIFY Arg1:T111 Arg2:E53 R63 MODIFY Arg1:T112 Arg2:E53 R64 MODIFY Arg1:T107 Arg2:E51 T113 Medication 2388 2405 antiviral therapy E55 Medication:T113 T114 Medication 2416 2425 ribavirin E57 Medication:T114 T115 Administration 2411 2415 oral T116 Dosage 2426 2439 400 mg q 12 h R65 MODIFY Arg1:T116 Arg2:E57 R66 MODIFY Arg1:T115 Arg2:E57 T117 Medication 2458 2469 antibiotics E58 Medication:T117 T118 Date 2483 2488 day 4 E59 Date:T118 T119 Sign_symptom 2494 2499 fever E60 Sign_symptom:T119 A5 POLARITY E60 NEG T120 Sign_symptom 2517 2525 symptoms E61 Sign_symptom:T120 A6 POLARITY E61 MAYBE_NEG T121 Diagnostic_procedure 2550 2562 transaminase E62 Diagnostic_procedure:T121 T122 Diagnostic_procedure 2571 2574 CRP E63 Diagnostic_procedure:T122 T123 Diagnostic_procedure 2579 2593 platelet count E64 Diagnostic_procedure:T123 T124 Lab_value 2605 2615 normalized R67 MODIFY Arg1:T124 Arg2:E64 R68 MODIFY Arg1:T124 Arg2:E63 R69 MODIFY Arg1:T124 Arg2:E62 T125 Diagnostic_procedure 2643 2648 X-ray E65 Diagnostic_procedure:T125 T126 Biological_structure 2637 2642 chest T127 Clinical_event 2627 2636 follow-up E66 Clinical_event:T127 R70 MODIFY Arg1:T126 Arg2:E65 T128 Lab_value 2653 2658 clear R71 MODIFY Arg1:T128 Arg2:E65 T129 Clinical_event 2679 2689 discharged E67 Clinical_event:T129 T130 Date 2702 2708 day 13 E68 Date:T130 T131 Sign_symptom 2721 2734 complications E69 Sign_symptom:T131 A7 POLARITY E69 NEG R72 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 E4 E5 R73 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E11 E13 E19 E20 E21 E27 E29 E28 E30 E31 E32 E33 E34 E35 E36 R74 BEFORE Arg1:E36 Arg2:E37 * OVERLAP E37 E38 E41 R75 BEFORE Arg1:E41 Arg2:E44 * OVERLAP E44 E42 E43 E45 E46 E47 E48 E50 E49 E51 E54 E53 E56 E55 E58 T132 Lab_value 2232 2240 negative R76 MODIFY Arg1:T132 Arg2:E54 R77 SUB_PROCEDURE Arg1:E57 Arg2:E55 R78 BEFORE Arg1:E58 Arg2:E59 * OVERLAP E59 E60 E61 E62 E63 E64 R79 BEFORE Arg1:E64 Arg2:E66 * OVERLAP E66 E65 R80 BEFORE Arg1:E65 Arg2:E67 * OVERLAP E67 E68 E69 T133 History 211 243 drank alcohol about once a month