--- a
+++ b/processing/MACCROBAT/28100235.ann
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+T1	Age 2 13	61-year-old
+T2	Sex 14 18	male
+T3	Clinical_event 23 31	referred
+E1	Clinical_event:T3 
+T4	Nonbiological_location 39 59	emergency department
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Date 91 101	April 2010
+E2	Date:T5 
+T6	Sign_symptom 161 172	black stool
+E3	Sign_symptom:T6 
+T7	Sign_symptom 123 142	loose bowel motions
+E4	Sign_symptom:T7 
+T8	History 203 246	insulin-dependent type II diabetes mellitus
+T9	History 248 260	hypertension
+T10	History 262 320	ischaemic heart disease with two previous ischaemic events
+T11	History 322 346	obstructive sleep apnoea
+T12	History 348 358	depression
+T13	History 360 373	schizophrenia
+T14	History 380 413	previous incisional hernia repair
+T15	Diagnostic_procedure 454 457	BMI
+E5	Diagnostic_procedure:T15 
+T16	Lab_value 458 460	45
+R2	MODIFY Arg1:T16 Arg2:E5	
+T17	Disease_disorder 438 452	morbidly obese
+E6	Disease_disorder:T17 
+T18	Disease_disorder 491 503	hepatomegaly
+E7	Disease_disorder:T18 
+T19	Sign_symptom 545 556	weight loss
+E8	Sign_symptom:T19 
+A1	POLARITY E8 NEG
+T20	Sign_symptom 558 570	haematemesis
+E9	Sign_symptom:T20 
+A2	POLARITY E9 NEG
+T21	Sign_symptom 572 580	jaundice
+E10	Sign_symptom:T21 
+A3	POLARITY E10 NEG
+T22	Sign_symptom 594 598	pain
+E11	Sign_symptom:T22 
+A4	POLARITY E11 NEG
+T23	Biological_structure 584 593	abdominal
+R3	MODIFY Arg1:T23 Arg2:E11	
+T24	History 612 700	denied previous blood transfusions, usage of intravenous drugs and did not drink alcohol
+T25	Diagnostic_procedure 704 728	faecal occult blood test
+E12	Diagnostic_procedure:T25 
+T26	Lab_value 733 741	negative
+R4	MODIFY Arg1:T26 Arg2:E12	
+T27	Diagnostic_procedure 766 777	colonoscopy
+E13	Diagnostic_procedure:T27 
+T28	Date 778 791	2 years prior
+E14	Date:T28 
+T29	Lab_value 796 808	unremarkable
+R5	MODIFY Arg1:T29 Arg2:E13	
+T30	Clinical_event 817 825	referred
+E15	Clinical_event:T30 
+T31	Nonbiological_location 833 848	tertiary centre
+R6	MODIFY Arg1:T31 Arg2:E15	
+T32	Diagnostic_procedure 881 896	ultrasound scan
+E16	Diagnostic_procedure:T32 
+T33	Diagnostic_procedure 898 901	USS
+E17	Diagnostic_procedure:T33 
+R7	IDENTICAL Arg1:E17 Arg2:E16	
+T34	Sign_symptom 922 926	mass
+E18	Sign_symptom:T34 
+T35	Shape 916 921	ovoid
+R8	MODIFY Arg1:T35 Arg2:E18	
+T36	Biological_structure 966 971	liver
+R9	MODIFY Arg1:T36 Arg2:E18	
+T37	Detailed_description 930 948	mixed echogenicity
+R10	MODIFY Arg1:T37 Arg2:E18	
+T38	Area 983 992	12 × 9 cm
+R11	MODIFY Arg1:T38 Arg2:E18	
+T39	Diagnostic_procedure 996 1015	computed tomography
+E19	Diagnostic_procedure:T39 
+T40	Diagnostic_procedure 1017 1019	CT
+E20	Diagnostic_procedure:T40 
+R12	IDENTICAL Arg1:E20 Arg2:E19	
+T41	Sign_symptom 1072 1078	lesion
+E21	Sign_symptom:T41 
+T42	Biological_structure 1091 1101	segment IV
+R13	MODIFY Arg1:T42 Arg2:E21	
+T43	Detailed_description 1059 1071	pedunculated
+T44	Detailed_description 1038 1057	malignant appearing
+R14	MODIFY Arg1:T43 Arg2:E21	
+R15	MODIFY Arg1:T44 Arg2:E21	
+T45	Diagnostic_procedure 1124 1150	magnetic resonance imaging
+E22	Diagnostic_procedure:T45 
+T46	Diagnostic_procedure 1152 1155	MRI
+E23	Diagnostic_procedure:T46 
+R16	IDENTICAL Arg1:E23 Arg2:E22	
+T47	Diagnostic_procedure 1178 1194	weighted imaging
+E24	Diagnostic_procedure:T47 
+T48	Diagnostic_procedure 1196 1198	WI
+E25	Diagnostic_procedure:T48 
+T49	Detailed_description 1175 1177	T2
+R17	MODIFY Arg1:T49 Arg2:E24	
+R18	IDENTICAL Arg1:E25 Arg2:E24	
+T50	Sign_symptom 1205 1211	lesion
+E26	Sign_symptom:T50 
+R19	SUB_PROCEDURE Arg1:E24 Arg2:E22	
+T51	Detailed_description 1216 1226	isointense
+R20	MODIFY Arg1:T51 Arg2:E26	
+T52	Biological_structure 1234 1239	liver
+R21	MODIFY Arg1:T52 Arg2:E26	
+T53	Detailed_description 1258 1292	central branching hyperintensities
+R22	MODIFY Arg1:T53 Arg2:E26	
+T54	Diagnostic_procedure 1352 1356	T1WI
+E27	Diagnostic_procedure:T54 
+T55	Sign_symptom 1328 1343	hypointensities
+E28	Sign_symptom:T55 
+R23	MODIFY Arg1:E28 Arg2:E27	
+T56	Sign_symptom 1386 1392	lesion
+E29	Sign_symptom:T56 
+T57	Detailed_description 1367 1378	Enhancement
+R24	MODIFY Arg1:T57 Arg2:E29	
+T58	Detailed_description 1406 1420	arterial phase
+T59	Detailed_description 1438 1457	portal venous phase
+T60	Detailed_description 1471 1479	at 2 min
+T61	Detailed_description 1500 1532	central areas of non-enhancement
+R25	MODIFY Arg1:T58 Arg2:E29	
+R26	MODIFY Arg1:T59 Arg2:E29	
+R27	MODIFY Arg1:T60 Arg2:E29	
+R28	MODIFY Arg1:T61 Arg2:E29	
+T62	Sign_symptom 1538 1544	lesion
+E30	Sign_symptom:T62 
+T63	Detailed_description 1553 1573	slightly hypointense
+T64	Detailed_description 1577 1591	delayed images
+T65	Biological_structure 1646 1651	liver
+R29	MODIFY Arg1:T65 Arg2:E30	
+R30	MODIFY Arg1:T63 Arg2:E30	
+R31	MODIFY Arg1:T64 Arg2:E30	
+T66	Detailed_description 1595 1597	10
+T67	Detailed_description 1611 1617	20 min
+R32	MODIFY Arg1:T66 Arg2:T63	
+R33	MODIFY Arg1:T67 Arg2:T63	
+T68	Diagnostic_procedure 1653 1678	Laboratory investigations
+E31	Diagnostic_procedure:T68 
+T69	Diagnostic_procedure 1706 1735	gamma-glutamyl transpeptidase
+E32	Diagnostic_procedure:T69 
+T70	Lab_value 1690 1705	mildly elevated
+R34	MODIFY Arg1:T70 Arg2:E32	
+T71	Lab_value 1739 1747	137 IU/L
+R35	MODIFY Arg1:T71 Arg2:E32	
+T72	Diagnostic_procedure 1768 1784	Hepatitis screen
+E33	Diagnostic_procedure:T72 
+T73	Diagnostic_procedure 1786 1803	alpha-fetoprotein
+E34	Diagnostic_procedure:T73 
+T74	Diagnostic_procedure 1805 1829	carcinoembryonic antigen
+E35	Diagnostic_procedure:T74 
+T75	Diagnostic_procedure 1834 1853	cancer antigen 19–9
+E36	Diagnostic_procedure:T75 
+T76	Lab_value 1863 1875	unremarkable
+R36	MODIFY Arg1:T76 Arg2:E36	
+R37	MODIFY Arg1:T76 Arg2:E35	
+R38	MODIFY Arg1:T76 Arg2:E34	
+R39	MODIFY Arg1:T76 Arg2:E33	
+T77	Therapeutic_procedure 1914 1923	resection
+E37	Therapeutic_procedure:T77 
+T78	Detailed_description 1901 1913	subsegmental
+R40	MODIFY Arg1:T78 Arg2:E37	
+T79	Sign_symptom 1949 1953	mass
+E38	Sign_symptom:T79 
+T80	Biological_structure 1937 1948	segment IVb
+T81	Distance 1931 1936	15 cm
+R41	MODIFY Arg1:T80 Arg2:E38	
+R42	MODIFY Arg1:T81 Arg2:E38	
+T82	Date 1957 1966	June 2010
+E39	Date:T82 
+T83	Disease_disorder 1985 2002	hepatic steatosis
+E40	Disease_disorder:T83 
+T84	Disease_disorder 2011 2020	cirrhosis
+E41	Disease_disorder:T84 
+A5	POLARITY E41 NEG
+T85	Severity 1978 1984	severe
+R43	MODIFY Arg1:T85 Arg2:E40	
+T86	Clinical_event 2038 2048	discharged
+E42	Clinical_event:T86 
+T87	Date 2063 2072	day seven
+E43	Date:T87 
+T88	Sign_symptom 2081 2094	complications
+E44	Sign_symptom:T88 
+A6	POLARITY E44 NEG
+T89	Diagnostic_procedure 2096 2105	Pathology
+E45	Diagnostic_procedure:T89 
+T90	Biological_structure 2113 2131	resection specimen
+R44	MODIFY Arg1:T90 Arg2:E45	
+T91	Disease_disorder 2142 2146	SFTL
+E46	Disease_disorder:T91 
+#1	AnnotatorNotes E46	Solitary fibrous tumors of the liver
+T92	Color 2173 2181	pale tan
+R45	MODIFY Arg1:T92 Arg2:E45	
+T93	Shape 2182 2200	nodular appearance
+T94	Texture 2208 2236	firm and rubbery cut surface
+R46	MODIFY Arg1:T93 Arg2:E45	
+R47	MODIFY Arg1:T94 Arg2:E45	
+T95	Diagnostic_procedure 2238 2262	Histological examination
+E47	Diagnostic_procedure:T95 
+T96	Lab_value 2272 2298	fascicles of spindle cells
+T97	Detailed_description 2302 2323	storiform arrangement
+T98	Detailed_description 2331 2345	pushing margin
+R48	MODIFY Arg1:T97 Arg2:T96	
+R49	MODIFY Arg1:T98 Arg2:T96	
+R50	MODIFY Arg1:T96 Arg2:E47	
+T99	Lab_value 2357 2402	evidence of extracellular collagen deposition
+T100	Lab_value 2404 2426	areas of myxoid stroma
+T101	Lab_value 2431 2467	branching vessels with hyalinisation
+R51	MODIFY Arg1:T99 Arg2:E47	
+R52	MODIFY Arg1:T100 Arg2:E47	
+R53	MODIFY Arg1:T101 Arg2:E47	
+T102	Biological_structure 2473 2481	specimen
+T103	Diagnostic_procedure 2499 2511	mitotic rate
+E48	Diagnostic_procedure:T103 
+T104	Lab_value 2494 2498	high
+R54	MODIFY Arg1:T104 Arg2:E48	
+R55	MODIFY Arg1:T102 Arg2:E48	
+T105	Lab_value 2521 2547	9 per 10 high-power fields
+R56	MODIFY Arg1:T105 Arg2:E48	
+T106	Lab_value 2559 2595	no necrotic or haemorrhagic features
+R57	MODIFY Arg1:T106 Arg2:E48	
+T107	Diagnostic_procedure 2597 2617	Immunohistochemistry
+E49	Diagnostic_procedure:T107 
+T108	Lab_value 2625 2633	positive
+T109	Diagnostic_procedure 2647 2651	CD34
+E50	Diagnostic_procedure:T109 
+T110	Diagnostic_procedure 2653 2657	CD99
+E51	Diagnostic_procedure:T110 
+T111	Diagnostic_procedure 2662 2667	BCL-2
+E52	Diagnostic_procedure:T111 
+R58	SUB_PROCEDURE Arg1:E50 Arg2:E49	
+R59	SUB_PROCEDURE Arg1:E51 Arg2:E49	
+R60	SUB_PROCEDURE Arg1:E52 Arg2:E49	
+R61	MODIFY Arg1:T108 Arg2:E50	
+R62	MODIFY Arg1:T108 Arg2:E51	
+R63	MODIFY Arg1:T108 Arg2:E52	
+T112	Diagnostic_procedure 2697 2702	c-Kit
+E53	Diagnostic_procedure:T112 
+T113	Diagnostic_procedure 2704 2708	CD31
+E54	Diagnostic_procedure:T113 
+T114	Diagnostic_procedure 2710 2713	SMA
+E55	Diagnostic_procedure:T114 
+T115	Diagnostic_procedure 2715 2721	desmin
+E56	Diagnostic_procedure:T115 
+T116	Diagnostic_procedure 2723 2735	cytokeratins
+E57	Diagnostic_procedure:T116 
+T117	Detailed_description 2737 2764	AE1/AE3, MNF116 and Cam 5.2
+R64	MODIFY Arg1:T117 Arg2:E57	
+T118	Diagnostic_procedure 2767 2770	EMA
+E58	Diagnostic_procedure:T118 
+T119	Diagnostic_procedure 2775 2779	S100
+E59	Diagnostic_procedure:T119 
+T120	Lab_value 2684 2692	negative
+R65	MODIFY Arg1:T120 Arg2:E53	
+R66	MODIFY Arg1:T120 Arg2:E54	
+R67	MODIFY Arg1:T120 Arg2:E55	
+R68	MODIFY Arg1:T120 Arg2:E56	
+R69	MODIFY Arg1:T120 Arg2:E57	
+R70	MODIFY Arg1:T120 Arg2:E58	
+R71	MODIFY Arg1:T120 Arg2:E59	
+R72	SUB_PROCEDURE Arg1:E53 Arg2:E49	
+R73	SUB_PROCEDURE Arg1:E54 Arg2:E49	
+R74	SUB_PROCEDURE Arg1:E55 Arg2:E49	
+R75	SUB_PROCEDURE Arg1:E56 Arg2:E49	
+R76	SUB_PROCEDURE Arg1:E57 Arg2:E49	
+R77	SUB_PROCEDURE Arg1:E58 Arg2:E49	
+R78	SUB_PROCEDURE Arg1:E59 Arg2:E49	
+T121	Disease_disorder 2893 2908	steatohepatitis
+E60	Disease_disorder:T121 
+T122	Sign_symptom 2870 2878	fibrosis
+E61	Sign_symptom:T122 
+T123	Detailed_description 2857 2869	pericellular
+R79	MODIFY Arg1:T123 Arg2:E61	
+T124	Biological_structure 2824 2846	remainder of the liver
+R80	MODIFY Arg1:T124 Arg2:E61	
+T125	Diagnostic_procedure 2785 2792	margins
+E62	Diagnostic_procedure:T125 
+T126	Lab_value 2798 2803	clear
+R81	MODIFY Arg1:T126 Arg2:E62	
+T127	Clinical_event 2926 2937	followed-up
+E63	Clinical_event:T127 
+T128	Frequency 2948 2967	every 4 to 6 months
+R82	MODIFY Arg1:T128 Arg2:E63	
+T129	Diagnostic_procedure 2973 2975	CT
+E64	Diagnostic_procedure:T129 
+T130	Nonbiological_location 2989 3015	local general practitioner
+T131	Nonbiological_location 3037 3055	consultant surgeon
+R83	MODIFY Arg1:T130 Arg2:E64	
+R84	MODIFY Arg1:T131 Arg2:E64	
+T132	Clinical_event 3084 3097	re-admissions
+E65	Clinical_event:T132 
+T133	Lab_value 3068 3071	two
+R85	MODIFY Arg1:T133 Arg2:E65	
+T134	Sign_symptom 3158 3162	pain
+E66	Sign_symptom:T134 
+T135	Biological_structure 3137 3157	right upper quadrant
+R86	MODIFY Arg1:T135 Arg2:E66	
+T136	Detailed_description 3127 3136	recurrent
+R87	MODIFY Arg1:T136 Arg2:E66	
+T137	Date 3163 3184	between 2011 and 2013
+E67	Date:T137 
+T138	Diagnostic_procedure 3195 3198	MRI
+E68	Diagnostic_procedure:T138 
+T139	Detailed_description 3186 3194	Multiple
+R88	MODIFY Arg1:T139 Arg2:E68	
+T140	Sign_symptom 3243 3272	expected postsurgical changes
+E69	Sign_symptom:T140 
+T141	Sign_symptom 3281 3298	tumour recurrence
+E70	Sign_symptom:T141 
+A7	POLARITY E70 NEG
+T142	Date 3312 3320	May 2016
+E71	Date:T142 
+T143	Clinical_event 3334 3343	presented
+E72	Clinical_event:T143 
+T144	Nonbiological_location 3351 3377	local emergency department
+R89	MODIFY Arg1:T144 Arg2:E72	
+T145	Sign_symptom 3428 3432	pain
+E73	Sign_symptom:T145 
+T146	Biological_structure 3407 3427	right upper quadrant
+R90	MODIFY Arg1:T146 Arg2:E73	
+A8	TREND E73 INC
+T147	Sign_symptom 3448 3456	dyspnoea
+E74	Sign_symptom:T147 
+A9	TREND E74 INC
+T148	Therapeutic_procedure 3465 3478	oxygen demand
+E75	Therapeutic_procedure:T148 
+T149	Diagnostic_procedure 3480 3482	CT
+E76	Diagnostic_procedure:T149 
+T150	Biological_structure 3490 3495	chest
+T151	Biological_structure 3497 3504	abdomen
+T152	Biological_structure 3509 3515	pelvis
+R91	MODIFY Arg1:T150 Arg2:E76	
+R92	MODIFY Arg1:T151 Arg2:E76	
+R93	MODIFY Arg1:T152 Arg2:E76	
+T153	Sign_symptom 3535 3552	tumour recurrence
+E77	Sign_symptom:T153 
+T154	Detailed_description 3525 3534	extensive
+R94	MODIFY Arg1:T154 Arg2:E77	
+T155	Biological_structure 3553 3592	adjacent to the previous resection site
+R95	MODIFY Arg1:T155 Arg2:E77	
+T156	Disease_disorder 3662 3678	pleural effusion
+E78	Disease_disorder:T156 
+T157	Detailed_description 3650 3661	right-sided
+R96	MODIFY Arg1:T157 Arg2:E78	
+T158	Sign_symptom 3693 3697	mass
+E79	Sign_symptom:T158 
+T159	Biological_structure 3685 3692	pleural
+R97	MODIFY Arg1:T159 Arg2:E79	
+T160	Biological_structure 3705 3720	right lung base
+R98	MODIFY Arg1:T160 Arg2:E79	
+T161	Date 3731 3737	3.8 cm
+E80	Date:T161 
+R99	BEFORE Arg1:E80 Arg2:E79	
+T162	Therapeutic_procedure 3747 3761	Pleurocentesis
+E81	Therapeutic_procedure:T162 
+T163	Volume 3786 3793	1400 ml
+T164	Biological_structure 3797 3818	serosanguineous fluid
+R100	MODIFY Arg1:T163 Arg2:T164	
+R101	MODIFY Arg1:T164 Arg2:E81	
+T165	Diagnostic_procedure 3820 3828	Cytology
+E82	Diagnostic_procedure:T165 
+T166	Diagnostic_procedure 3846 3861	malignant cells
+E83	Diagnostic_procedure:T166 
+R102	SUB_PROCEDURE Arg1:E83 Arg2:E82	
+T167	Lab_value 3833 3841	negative
+R103	MODIFY Arg1:T167 Arg2:E83	
+T168	Clinical_event 3876 3885	discussed
+E84	Clinical_event:T168 
+T169	Nonbiological_location 3903 3929	multi-disciplinary setting
+R104	MODIFY Arg1:T169 Arg2:E84	
+T170	Therapeutic_procedure 4066 4077	reoperation
+E85	Therapeutic_procedure:T170 
+A10	POLARITY E85 NEG
+T171	Medication 4107 4112	chemo
+E86	Medication:T171 
+A11	POLARITY E86 NEG
+T172	Therapeutic_procedure 4117 4143	radiotherapeutic therapies
+E87	Therapeutic_procedure:T172 
+A12	POLARITY E87 NEG
+T173	Clinical_event 4184 4192	referred
+E88	Clinical_event:T173 
+T174	Nonbiological_location 4200 4215	palliative team
+R105	MODIFY Arg1:T174 Arg2:E88	
+T175	Clinical_event 4251 4261	discharged
+E89	Clinical_event:T175 
+T176	Nonbiological_location 4274 4283	community
+R106	MODIFY Arg1:T176 Arg2:E89	
+T177	Sign_symptom 4298 4303	alive
+E90	Sign_symptom:T177 
+T178	Date 4304 4317	1 month after
+E91	Date:T178 
+*	OVERLAP E1 E2 E4 E3
+R108	BEFORE Arg1:E3 Arg2:E6	
+*	OVERLAP E6 E5 E7 E8 E9 E10 E11 E12
+R109	AFTER Arg1:E12 Arg2:E13	
+*	OVERLAP E13 E14
+R110	BEFORE Arg1:E14 Arg2:E15	
+*	OVERLAP E15 E16 E18 E19 E21 E22 E26 E28 E29 E30 E31 E32 E33 E34 E35 E36
+R111	SUB_PROCEDURE Arg1:E27 Arg2:E22	
+R112	BEFORE Arg1:E36 Arg2:E37	
+*	OVERLAP E37 E38 E39 E40 E41
+R113	BEFORE Arg1:E41 Arg2:E42	
+*	OVERLAP E42 E43 E44 E45 E46 E47 E48 E49 E62 E61 E60
+R114	BEFORE Arg1:E60 Arg2:E63	
+*	OVERLAP E63 E64
+R115	BEFORE Arg1:E64 Arg2:E65	
+*	OVERLAP E65 E66 E67 E68 E69 E70
+R116	BEFORE Arg1:E70 Arg2:E71	
+*	OVERLAP E71 E72 E73 E74 E75 E76 E77 E78 E79 E81 E82
+R117	BEFORE Arg1:E82 Arg2:E84	
+*	OVERLAP E84 E85 E86 E87
+R118	BEFORE Arg1:E87 Arg2:E88	
+*	OVERLAP E88 E89
+R119	BEFORE Arg1:E89 Arg2:E90	
+*	OVERLAP E90 E91