--- a
+++ b/processing/MACCROBAT/28079821.ann
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+T1	Age 2 13	67-year-old
+T2	Sex 14 19	woman
+T3	Clinical_event 24 28	sent
+E1	Clinical_event:T3 
+T4	Nonbiological_location 32 52	emergency department
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Sign_symptom 64 69	fever
+E2	Sign_symptom:T5 
+T6	Sign_symptom 74 78	sore
+E3	Sign_symptom:T6 
+T7	Biological_structure 79 85	throat
+R2	MODIFY Arg1:T7 Arg2:E3	
+T8	History 116 120	ESRD
+#1	AnnotatorNotes T8	End-stage renal disease
+T9	Disease_disorder 116 120	ESRD
+E4	Disease_disorder:T9 
+#2	AnnotatorNotes E4	End-stage renal disease
+T10	Duration 168 176	15 years
+E5	Duration:T10 
+T11	Frequency 147 163	3 times per week
+T12	Therapeutic_procedure 134 146	hemodialysis
+E6	Therapeutic_procedure:T12 
+R3	MODIFY Arg1:T11 Arg2:E6	
+T13	Disease_disorder 178 191	hyperuricemia
+E7	Disease_disorder:T13 
+T14	Disease_disorder 196 200	gout
+E8	Disease_disorder:T14 
+T15	History 178 191	hyperuricemia
+T16	History 196 200	gout
+T17	Disease_disorder 235 247	dyslipidemia
+E9	Disease_disorder:T17 
+T18	Sign_symptom 249 261	hypertension
+E10	Sign_symptom:T18 
+T19	Disease_disorder 273 292	hyperparathyroidism
+E11	Disease_disorder:T19 
+T20	Disease_disorder 298 306	diabetes
+E12	Disease_disorder:T20 
+T21	Detailed_description 263 272	secondary
+R4	MODIFY Arg1:T21 Arg2:E11	
+T22	History 235 247	dyslipidemia
+T23	History 249 261	hypertension
+T24	History 273 292	hyperparathyroidism
+T25	History 298 306	diabetes
+T26	Diagnostic_procedure 312 320	hemogram
+E13	Diagnostic_procedure:T26 
+T27	Medication 639 650	antibiotics
+E14	Medication:T27 
+T28	Detailed_description 624 638	Broad-spectrum
+R5	MODIFY Arg1:T28 Arg2:E14	
+T29	Medication 656 668	piperacillin
+E15	Medication:T29 
+T30	Medication 677 687	tazobactam
+E16	Medication:T30 
+T31	Administration 696 700	i.v.
+R6	MODIFY Arg1:T31 Arg2:E16	
+T32	Dosage 688 695	0.25 gm
+R7	MODIFY Arg1:T32 Arg2:E16	
+T33	Dosage 669 672	2 g
+R8	MODIFY Arg1:T33 Arg2:E15	
+R9	SUB_PROCEDURE Arg1:E15 Arg2:E14	
+R10	SUB_PROCEDURE Arg1:E16 Arg2:E14	
+T34	Diagnostic_procedure 1927 1946	Chromosome analysis
+E17	Diagnostic_procedure:T34 
+T35	Biological_structure 1950 1961	bone marrow
+R11	MODIFY Arg1:T35 Arg2:E17	
+T36	Lab_value 1966 1982	normal karyotype
+R12	MODIFY Arg1:T36 Arg2:E17	
+T37	History 1996 2045	denied history of radiation or chemicals exposure
+T38	Medication 2062 2072	febuxostat
+E18	Medication:T38 
+A1	POLARITY E18 NEG
+T39	Duration 2077 2084	17 days
+E19	Duration:T39 
+T40	Clinical_event 2233 2242	discharge
+E20	Clinical_event:T40 
+T41	Diagnostic_procedure 2248 2251	WBC
+E21	Diagnostic_procedure:T41 
+T42	Diagnostic_procedure 2256 2274	differential count
+E22	Diagnostic_procedure:T42 
+T43	Lab_value 2290 2296	normal
+R13	MODIFY Arg1:T43 Arg2:E22	
+R14	MODIFY Arg1:T43 Arg2:E21	
+T44	Clinical_event 2304 2313	follow-up
+E23	Clinical_event:T44 
+T45	Medication 1060 1070	febuxostat
+E24	Medication:T45 
+T46	Diagnostic_procedure 332 354	white blood cell count
+E25	Diagnostic_procedure:T46 
+T47	Diagnostic_procedure 356 359	WBC
+E26	Diagnostic_procedure:T47 
+R15	IDENTICAL Arg1:E26 Arg2:E25	
+R16	SUB_PROCEDURE Arg1:E25 Arg2:E13	
+T48	Lab_value 364 370	700/μL
+R17	MODIFY Arg1:T48 Arg2:E25	
+T49	Diagnostic_procedure 380 391	neutrophils
+E27	Diagnostic_procedure:T49 
+T50	Diagnostic_procedure 397 408	lymphocytes
+E28	Diagnostic_procedure:T50 
+T51	Diagnostic_procedure 416 425	monocytes
+E29	Diagnostic_procedure:T51 
+T52	Diagnostic_procedure 427 437	hemoglobin
+E30	Diagnostic_procedure:T52 
+T53	Diagnostic_procedure 453 467	platelet count
+E31	Diagnostic_procedure:T53 
+T54	Lab_value 469 479	131,000/μL
+R18	MODIFY Arg1:T54 Arg2:E31	
+T55	Lab_value 438 447	11.1 g/dL
+R19	MODIFY Arg1:T55 Arg2:E30	
+T56	Lab_value 413 415	2%
+R20	MODIFY Arg1:T56 Arg2:E29	
+T57	Lab_value 393 396	94%
+R21	MODIFY Arg1:T57 Arg2:E28	
+T58	Lab_value 377 379	2%
+R22	MODIFY Arg1:T58 Arg2:E27	
+R23	SUB_PROCEDURE Arg1:E27 Arg2:E13	
+R24	SUB_PROCEDURE Arg1:E28 Arg2:E13	
+R25	SUB_PROCEDURE Arg1:E29 Arg2:E13	
+R26	SUB_PROCEDURE Arg1:E30 Arg2:E13	
+R27	SUB_PROCEDURE Arg1:E31 Arg2:E13	
+T59	Sign_symptom 513 524	neutropenia
+E32	Sign_symptom:T59 
+A2	POLARITY E32 UNCERTAIN
+T60	Detailed_description 505 512	febrile
+R28	MODIFY Arg1:T60 Arg2:E32	
+T61	Detailed_description 529 534	acute
+T62	Disease_disorder 535 546	pharyngitis
+E33	Disease_disorder:T62 
+R29	MODIFY Arg1:T61 Arg2:E33	
+T63	Clinical_event 556 564	admitted
+E34	Clinical_event:T63 
+T64	Nonbiological_location 572 588	hematologic ward
+R30	MODIFY Arg1:T64 Arg2:E34	
+T65	Dosage 701 704	q8h
+#3	AnnotatorNotes T65	every 8 hours
+R31	MODIFY Arg1:T65 Arg2:E16	
+T66	Sign_symptom 735 749	infection sign
+E35	Sign_symptom:T66 
+A3	TREND E35 DEC
+T67	Medication 819 828	glipizide
+E36	Medication:T67 
+T68	Medication 839 850	saxagliptin
+E37	Medication:T68 
+T69	Medication 862 873	fenofibrate
+E38	Medication:T69 
+T70	Medication 885 903	aluminum hydroxide
+E39	Medication:T70 
+T71	Medication 916 926	folic acid
+E40	Medication:T71 
+T72	Medication 936 953	calcium carbonate
+E41	Medication:T72 
+T73	Medication 971 981	febuxostat
+E42	Medication:T73 
+T74	Duration 1110 1126	more than 1 year
+E43	Duration:T74 
+T75	Medication 1019 1031	epoetin-beta
+E44	Medication:T75 
+T76	Dosage 1032 1039	2000 iu
+T77	Administration 1040 1044	i.v.
+T78	Dosage 1044 1047	tiw
+#4	AnnotatorNotes T78	three times a week
+R32	MODIFY Arg1:T78 Arg2:E44	
+R33	MODIFY Arg1:T76 Arg2:E44	
+R34	MODIFY Arg1:T77 Arg2:E44	
+T79	Dosage 851 860	2.5 mg qd
+T80	Dosage 829 837	5 mg tid
+R35	MODIFY Arg1:T80 Arg2:E36	
+R36	MODIFY Arg1:T79 Arg2:E37	
+T81	Dosage 874 883	600 mg qd
+R37	MODIFY Arg1:T81 Arg2:E38	
+T82	Dosage 904 914	324 mg tid
+R38	MODIFY Arg1:T82 Arg2:E39	
+T83	Dosage 927 934	5 mg qd
+T84	Dosage 954 965	1000 mg tid
+T85	Dosage 982 990	40 mg qd
+R39	MODIFY Arg1:T85 Arg2:E42	
+R40	MODIFY Arg1:T84 Arg2:E41	
+R41	MODIFY Arg1:T83 Arg2:E40	
+T86	Medication 1128 1138	Febuxostat
+E45	Medication:T86 
+T87	Date 1156 1172	2½ months before
+E46	Date:T87 
+T88	Medication 1225 1236	allopurinol
+E47	Medication:T88 
+T89	Dosage 1237 1245	50 mg qd
+R42	MODIFY Arg1:T89 Arg2:E47	
+T90	Date 1247 1263	Two weeks before
+E48	Date:T90 
+T91	Diagnostic_procedure 1293 1308	laboratory test
+E49	Diagnostic_procedure:T91 
+T92	Diagnostic_procedure 1318 1321	WBC
+E50	Diagnostic_procedure:T92 
+R43	SUB_PROCEDURE Arg1:E50 Arg2:E49	
+T93	Lab_value 1322 1329	6000/μL
+R44	MODIFY Arg1:T93 Arg2:E50	
+T94	Diagnostic_procedure 1340 1349	uric acid
+E51	Diagnostic_procedure:T94 
+T95	Detailed_description 1334 1339	serum
+R45	MODIFY Arg1:T95 Arg2:E51	
+T96	Lab_value 1356 1365	9.8 mg/dL
+R46	MODIFY Arg1:T96 Arg2:E51	
+T97	Medication 1367 1377	Febuxostat
+E52	Medication:T97 
+A4	POLARITY E52 NEG
+T98	Disease_disorder 1440 1455	agranulocytosis
+E53	Disease_disorder:T98 
+T99	Disease_disorder 1661 1671	infections
+E54	Disease_disorder:T99 
+A5	POLARITY E54 NEG
+T100	Detailed_description 1632 1660	human immunodeficiency virus
+T101	Detailed_description 1612 1627	cytomegalovirus
+T102	Detailed_description 1592 1610	Epstein–Barr virus
+R47	MODIFY Arg1:T100 Arg2:E54	
+R48	MODIFY Arg1:T101 Arg2:E54	
+R49	MODIFY Arg1:T102 Arg2:E54	
+T103	Diagnostic_procedure 1673 1693	antinuclear antibody
+E55	Diagnostic_procedure:T103 
+T104	Diagnostic_procedure 1695 1698	ANA
+E56	Diagnostic_procedure:T104 
+R50	IDENTICAL Arg1:E56 Arg2:E55	
+T105	Diagnostic_procedure 1704 1735	antiextractable nuclear antigen
+E57	Diagnostic_procedure:T105 
+T106	Diagnostic_procedure 1737 1745	anti-ENA
+E58	Diagnostic_procedure:T106 
+R51	IDENTICAL Arg1:E58 Arg2:E57	
+T107	Lab_value 1757 1765	negative
+R52	MODIFY Arg1:T107 Arg2:E57	
+R53	MODIFY Arg1:T107 Arg2:E55	
+T108	Diagnostic_procedure 1767 1790	Bone marrow examination
+E59	Diagnostic_procedure:T108 
+T109	Sign_symptom 1821 1833	hypocellular
+E60	Sign_symptom:T109 
+T110	Biological_structure 1834 1840	marrow
+R54	MODIFY Arg1:T110 Arg2:E60	
+T111	Diagnostic_procedure 1867 1884	myeloid component
+E61	Diagnostic_procedure:T111 
+T112	Lab_value 1855 1863	decrease
+R55	MODIFY Arg1:T112 Arg2:E61	
+T113	Sign_symptom 1916 1925	neoplasms
+E62	Sign_symptom:T113 
+A6	POLARITY E62 NEG
+T114	Biological_structure 1904 1915	hematologic
+R56	MODIFY Arg1:T114 Arg2:E62	
+T115	Sign_symptom 2090 2101	neutropenia
+E63	Sign_symptom:T115 
+A7	TREND E63 DEC
+T116	Diagnostic_procedure 2126 2129	WBC
+E64	Diagnostic_procedure:T116 
+T117	Diagnostic_procedure 2143 2153	neutrophil
+E65	Diagnostic_procedure:T117 
+T118	Lab_value 2130 2137	2100/μL
+R57	MODIFY Arg1:T118 Arg2:E64	
+T119	Lab_value 2154 2157	66%
+R58	MODIFY Arg1:T119 Arg2:E65	
+T120	Medication 2172 2209	granulocyte colony-stimulating factor
+E66	Medication:T120 
+A8	POLARITY E66 NEG
+R59	AFTER Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E3
+R60	AFTER Arg1:E3 Arg2:E4	
+*	OVERLAP E4 E6 E5 E7 E8 E9 E10 E11 E12
+R61	BEFORE Arg1:E12 Arg2:E13	
+*	OVERLAP E13 E32 E33
+R62	BEFORE Arg1:E33 Arg2:E34	
+*	OVERLAP E34 E14
+R63	BEFORE Arg1:E14 Arg2:E35	
+R64	AFTER Arg1:E35 Arg2:E36	
+*	OVERLAP E36 E37 E38 E39 E40 E41 E42 E44 E24 E43
+A9	POLARITY E24 NEG
+R65	BEFORE Arg1:E43 Arg2:E45	
+*	OVERLAP E45 E46 E47
+R66	AFTER Arg1:E47 Arg2:E48	
+*	OVERLAP E48 E49
+R67	SUB_PROCEDURE Arg1:E51 Arg2:E49	
+R68	BEFORE Arg1:E49 Arg2:E52	
+*	OVERLAP E52 E53 E54 E55 E57 E59 E60 E61 E62 E17
+R69	BEFORE Arg1:E17 Arg2:E18	
+*	OVERLAP E18 E19
+R70	BEFORE Arg1:E19 Arg2:E63	
+*	OVERLAP E63 E64 E65 E66
+R71	BEFORE Arg1:E66 Arg2:E20	
+R72	BEFORE Arg1:E20 Arg2:E21	
+*	OVERLAP E21 E22 E23