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T1 Age 2 13 67-year-old T2 Sex 14 19 woman T3 Clinical_event 24 28 sent E1 Clinical_event:T3 T4 Nonbiological_location 32 52 emergency department R1 MODIFY Arg1:T4 Arg2:E1 T5 Sign_symptom 64 69 fever E2 Sign_symptom:T5 T6 Sign_symptom 74 78 sore E3 Sign_symptom:T6 T7 Biological_structure 79 85 throat R2 MODIFY Arg1:T7 Arg2:E3 T8 History 116 120 ESRD #1 AnnotatorNotes T8 End-stage renal disease T9 Disease_disorder 116 120 ESRD E4 Disease_disorder:T9 #2 AnnotatorNotes E4 End-stage renal disease T10 Duration 168 176 15 years E5 Duration:T10 T11 Frequency 147 163 3 times per week T12 Therapeutic_procedure 134 146 hemodialysis E6 Therapeutic_procedure:T12 R3 MODIFY Arg1:T11 Arg2:E6 T13 Disease_disorder 178 191 hyperuricemia E7 Disease_disorder:T13 T14 Disease_disorder 196 200 gout E8 Disease_disorder:T14 T15 History 178 191 hyperuricemia T16 History 196 200 gout T17 Disease_disorder 235 247 dyslipidemia E9 Disease_disorder:T17 T18 Sign_symptom 249 261 hypertension E10 Sign_symptom:T18 T19 Disease_disorder 273 292 hyperparathyroidism E11 Disease_disorder:T19 T20 Disease_disorder 298 306 diabetes E12 Disease_disorder:T20 T21 Detailed_description 263 272 secondary R4 MODIFY Arg1:T21 Arg2:E11 T22 History 235 247 dyslipidemia T23 History 249 261 hypertension T24 History 273 292 hyperparathyroidism T25 History 298 306 diabetes T26 Diagnostic_procedure 312 320 hemogram E13 Diagnostic_procedure:T26 T27 Medication 639 650 antibiotics E14 Medication:T27 T28 Detailed_description 624 638 Broad-spectrum R5 MODIFY Arg1:T28 Arg2:E14 T29 Medication 656 668 piperacillin E15 Medication:T29 T30 Medication 677 687 tazobactam E16 Medication:T30 T31 Administration 696 700 i.v. R6 MODIFY Arg1:T31 Arg2:E16 T32 Dosage 688 695 0.25 gm R7 MODIFY Arg1:T32 Arg2:E16 T33 Dosage 669 672 2 g R8 MODIFY Arg1:T33 Arg2:E15 R9 SUB_PROCEDURE Arg1:E15 Arg2:E14 R10 SUB_PROCEDURE Arg1:E16 Arg2:E14 T34 Diagnostic_procedure 1927 1946 Chromosome analysis E17 Diagnostic_procedure:T34 T35 Biological_structure 1950 1961 bone marrow R11 MODIFY Arg1:T35 Arg2:E17 T36 Lab_value 1966 1982 normal karyotype R12 MODIFY Arg1:T36 Arg2:E17 T37 History 1996 2045 denied history of radiation or chemicals exposure T38 Medication 2062 2072 febuxostat E18 Medication:T38 A1 POLARITY E18 NEG T39 Duration 2077 2084 17 days E19 Duration:T39 T40 Clinical_event 2233 2242 discharge E20 Clinical_event:T40 T41 Diagnostic_procedure 2248 2251 WBC E21 Diagnostic_procedure:T41 T42 Diagnostic_procedure 2256 2274 differential count E22 Diagnostic_procedure:T42 T43 Lab_value 2290 2296 normal R13 MODIFY Arg1:T43 Arg2:E22 R14 MODIFY Arg1:T43 Arg2:E21 T44 Clinical_event 2304 2313 follow-up E23 Clinical_event:T44 T45 Medication 1060 1070 febuxostat E24 Medication:T45 T46 Diagnostic_procedure 332 354 white blood cell count E25 Diagnostic_procedure:T46 T47 Diagnostic_procedure 356 359 WBC E26 Diagnostic_procedure:T47 R15 IDENTICAL Arg1:E26 Arg2:E25 R16 SUB_PROCEDURE Arg1:E25 Arg2:E13 T48 Lab_value 364 370 700/μL R17 MODIFY Arg1:T48 Arg2:E25 T49 Diagnostic_procedure 380 391 neutrophils E27 Diagnostic_procedure:T49 T50 Diagnostic_procedure 397 408 lymphocytes E28 Diagnostic_procedure:T50 T51 Diagnostic_procedure 416 425 monocytes E29 Diagnostic_procedure:T51 T52 Diagnostic_procedure 427 437 hemoglobin E30 Diagnostic_procedure:T52 T53 Diagnostic_procedure 453 467 platelet count E31 Diagnostic_procedure:T53 T54 Lab_value 469 479 131,000/μL R18 MODIFY Arg1:T54 Arg2:E31 T55 Lab_value 438 447 11.1 g/dL R19 MODIFY Arg1:T55 Arg2:E30 T56 Lab_value 413 415 2% R20 MODIFY Arg1:T56 Arg2:E29 T57 Lab_value 393 396 94% R21 MODIFY Arg1:T57 Arg2:E28 T58 Lab_value 377 379 2% R22 MODIFY Arg1:T58 Arg2:E27 R23 SUB_PROCEDURE Arg1:E27 Arg2:E13 R24 SUB_PROCEDURE Arg1:E28 Arg2:E13 R25 SUB_PROCEDURE Arg1:E29 Arg2:E13 R26 SUB_PROCEDURE Arg1:E30 Arg2:E13 R27 SUB_PROCEDURE Arg1:E31 Arg2:E13 T59 Sign_symptom 513 524 neutropenia E32 Sign_symptom:T59 A2 POLARITY E32 UNCERTAIN T60 Detailed_description 505 512 febrile R28 MODIFY Arg1:T60 Arg2:E32 T61 Detailed_description 529 534 acute T62 Disease_disorder 535 546 pharyngitis E33 Disease_disorder:T62 R29 MODIFY Arg1:T61 Arg2:E33 T63 Clinical_event 556 564 admitted E34 Clinical_event:T63 T64 Nonbiological_location 572 588 hematologic ward R30 MODIFY Arg1:T64 Arg2:E34 T65 Dosage 701 704 q8h #3 AnnotatorNotes T65 every 8 hours R31 MODIFY Arg1:T65 Arg2:E16 T66 Sign_symptom 735 749 infection sign E35 Sign_symptom:T66 A3 TREND E35 DEC T67 Medication 819 828 glipizide E36 Medication:T67 T68 Medication 839 850 saxagliptin E37 Medication:T68 T69 Medication 862 873 fenofibrate E38 Medication:T69 T70 Medication 885 903 aluminum hydroxide E39 Medication:T70 T71 Medication 916 926 folic acid E40 Medication:T71 T72 Medication 936 953 calcium carbonate E41 Medication:T72 T73 Medication 971 981 febuxostat E42 Medication:T73 T74 Duration 1110 1126 more than 1 year E43 Duration:T74 T75 Medication 1019 1031 epoetin-beta E44 Medication:T75 T76 Dosage 1032 1039 2000 iu T77 Administration 1040 1044 i.v. T78 Dosage 1044 1047 tiw #4 AnnotatorNotes T78 three times a week R32 MODIFY Arg1:T78 Arg2:E44 R33 MODIFY Arg1:T76 Arg2:E44 R34 MODIFY Arg1:T77 Arg2:E44 T79 Dosage 851 860 2.5 mg qd T80 Dosage 829 837 5 mg tid R35 MODIFY Arg1:T80 Arg2:E36 R36 MODIFY Arg1:T79 Arg2:E37 T81 Dosage 874 883 600 mg qd R37 MODIFY Arg1:T81 Arg2:E38 T82 Dosage 904 914 324 mg tid R38 MODIFY Arg1:T82 Arg2:E39 T83 Dosage 927 934 5 mg qd T84 Dosage 954 965 1000 mg tid T85 Dosage 982 990 40 mg qd R39 MODIFY Arg1:T85 Arg2:E42 R40 MODIFY Arg1:T84 Arg2:E41 R41 MODIFY Arg1:T83 Arg2:E40 T86 Medication 1128 1138 Febuxostat E45 Medication:T86 T87 Date 1156 1172 2½ months before E46 Date:T87 T88 Medication 1225 1236 allopurinol E47 Medication:T88 T89 Dosage 1237 1245 50 mg qd R42 MODIFY Arg1:T89 Arg2:E47 T90 Date 1247 1263 Two weeks before E48 Date:T90 T91 Diagnostic_procedure 1293 1308 laboratory test E49 Diagnostic_procedure:T91 T92 Diagnostic_procedure 1318 1321 WBC E50 Diagnostic_procedure:T92 R43 SUB_PROCEDURE Arg1:E50 Arg2:E49 T93 Lab_value 1322 1329 6000/μL R44 MODIFY Arg1:T93 Arg2:E50 T94 Diagnostic_procedure 1340 1349 uric acid E51 Diagnostic_procedure:T94 T95 Detailed_description 1334 1339 serum R45 MODIFY Arg1:T95 Arg2:E51 T96 Lab_value 1356 1365 9.8 mg/dL R46 MODIFY Arg1:T96 Arg2:E51 T97 Medication 1367 1377 Febuxostat E52 Medication:T97 A4 POLARITY E52 NEG T98 Disease_disorder 1440 1455 agranulocytosis E53 Disease_disorder:T98 T99 Disease_disorder 1661 1671 infections E54 Disease_disorder:T99 A5 POLARITY E54 NEG T100 Detailed_description 1632 1660 human immunodeficiency virus T101 Detailed_description 1612 1627 cytomegalovirus T102 Detailed_description 1592 1610 Epstein–Barr virus R47 MODIFY Arg1:T100 Arg2:E54 R48 MODIFY Arg1:T101 Arg2:E54 R49 MODIFY Arg1:T102 Arg2:E54 T103 Diagnostic_procedure 1673 1693 antinuclear antibody E55 Diagnostic_procedure:T103 T104 Diagnostic_procedure 1695 1698 ANA E56 Diagnostic_procedure:T104 R50 IDENTICAL Arg1:E56 Arg2:E55 T105 Diagnostic_procedure 1704 1735 antiextractable nuclear antigen E57 Diagnostic_procedure:T105 T106 Diagnostic_procedure 1737 1745 anti-ENA E58 Diagnostic_procedure:T106 R51 IDENTICAL Arg1:E58 Arg2:E57 T107 Lab_value 1757 1765 negative R52 MODIFY Arg1:T107 Arg2:E57 R53 MODIFY Arg1:T107 Arg2:E55 T108 Diagnostic_procedure 1767 1790 Bone marrow examination E59 Diagnostic_procedure:T108 T109 Sign_symptom 1821 1833 hypocellular E60 Sign_symptom:T109 T110 Biological_structure 1834 1840 marrow R54 MODIFY Arg1:T110 Arg2:E60 T111 Diagnostic_procedure 1867 1884 myeloid component E61 Diagnostic_procedure:T111 T112 Lab_value 1855 1863 decrease R55 MODIFY Arg1:T112 Arg2:E61 T113 Sign_symptom 1916 1925 neoplasms E62 Sign_symptom:T113 A6 POLARITY E62 NEG T114 Biological_structure 1904 1915 hematologic R56 MODIFY Arg1:T114 Arg2:E62 T115 Sign_symptom 2090 2101 neutropenia E63 Sign_symptom:T115 A7 TREND E63 DEC T116 Diagnostic_procedure 2126 2129 WBC E64 Diagnostic_procedure:T116 T117 Diagnostic_procedure 2143 2153 neutrophil E65 Diagnostic_procedure:T117 T118 Lab_value 2130 2137 2100/μL R57 MODIFY Arg1:T118 Arg2:E64 T119 Lab_value 2154 2157 66% R58 MODIFY Arg1:T119 Arg2:E65 T120 Medication 2172 2209 granulocyte colony-stimulating factor E66 Medication:T120 A8 POLARITY E66 NEG R59 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 R60 AFTER Arg1:E3 Arg2:E4 * OVERLAP E4 E6 E5 E7 E8 E9 E10 E11 E12 R61 BEFORE Arg1:E12 Arg2:E13 * OVERLAP E13 E32 E33 R62 BEFORE Arg1:E33 Arg2:E34 * OVERLAP E34 E14 R63 BEFORE Arg1:E14 Arg2:E35 R64 AFTER Arg1:E35 Arg2:E36 * OVERLAP E36 E37 E38 E39 E40 E41 E42 E44 E24 E43 A9 POLARITY E24 NEG R65 BEFORE Arg1:E43 Arg2:E45 * OVERLAP E45 E46 E47 R66 AFTER Arg1:E47 Arg2:E48 * OVERLAP E48 E49 R67 SUB_PROCEDURE Arg1:E51 Arg2:E49 R68 BEFORE Arg1:E49 Arg2:E52 * OVERLAP E52 E53 E54 E55 E57 E59 E60 E61 E62 E17 R69 BEFORE Arg1:E17 Arg2:E18 * OVERLAP E18 E19 R70 BEFORE Arg1:E19 Arg2:E63 * OVERLAP E63 E64 E65 E66 R71 BEFORE Arg1:E66 Arg2:E20 R72 BEFORE Arg1:E20 Arg2:E21 * OVERLAP E21 E22 E23