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T1 Age 2 13 73-year-old T2 Personal_background 14 22 Hispanic T3 Sex 23 27 male T4 Disease_disorder 55 77 chronic kidney disease E1 Disease_disorder:T4 T5 History 55 77 chronic kidney disease T6 Medication 2360 2367 Aspirin E2 Medication:T6 T7 Disease_disorder 95 118 coronary artery disease E3 Disease_disorder:T7 T8 Detailed_description 82 94 three-vessel R1 MODIFY Arg1:T8 Arg2:E3 T9 Therapeutic_procedure 136 172 coronary artery bypass graft surgery E4 Therapeutic_procedure:T9 T10 Therapeutic_procedure 177 196 mitral valve repair E5 Therapeutic_procedure:T10 T11 Date 216 223 day two E6 Date:T11 T12 Sign_symptom 247 264 cardiac tamponade E7 Sign_symptom:T12 T13 Disease_disorder 298 312 cardiac arrest E8 Disease_disorder:T13 T14 Therapeutic_procedure 319 341 temporary pacing wires E9 Therapeutic_procedure:T14 A1 POLARITY E9 MAYBE_NEG T15 Therapeutic_procedure 371 398 cardiovascular life support E10 Therapeutic_procedure:T15 T16 Therapeutic_procedure 424 434 sternotomy E11 Therapeutic_procedure:T16 T17 Detailed_description 412 423 exploratory R2 MODIFY Arg1:T17 Arg2:E11 T18 Clinical_event 471 482 transferred E12 Clinical_event:T18 T19 Nonbiological_location 490 509 intensive care unit T20 Nonbiological_location 511 514 ICU R3 IDENTICAL Arg1:T20 Arg2:T19 R4 MODIFY Arg1:T19 Arg2:E12 T21 Disease_disorder 574 587 renal failure E13 Disease_disorder:T21 A2 TREND E13 INC T22 Therapeutic_procedure 610 622 hemodialysis E14 Therapeutic_procedure:T22 T23 Therapeutic_procedure 626 642 nasogastric tube E15 Therapeutic_procedure:T23 T24 Date 672 679 day two E16 Date:T24 T25 Therapeutic_procedure 703 720 enteral nutrition E17 Therapeutic_procedure:T25 T26 Detailed_description 46 54 stage IV R5 MODIFY Arg1:T26 Arg2:E1 T27 Sign_symptom 765 785 cognitive impairment E18 Sign_symptom:T27 T28 Diagnostic_procedure 795 814 swallowing function E19 Diagnostic_procedure:T28 T29 Diagnostic_procedure 822 850 Modified Barium Swallow test E20 Diagnostic_procedure:T29 R6 SUB_PROCEDURE Arg1:E20 Arg2:E19 T30 Lab_value 790 794 poor E21 Lab_value:T30 R7 MODIFY Arg1:E21 Arg2:E20 T31 Diagnostic_procedure 856 875 coagulation profile E22 Diagnostic_procedure:T31 T32 Diagnostic_procedure 911 941 international normalized ratio E23 Diagnostic_procedure:T32 R8 SUB_PROCEDURE Arg1:E23 Arg2:E22 T33 Lab_value 945 949 1.04 E24 Lab_value:T33 R9 MODIFY Arg1:E24 Arg2:E23 T34 Diagnostic_procedure 954 981 partial thromboplastin time E25 Diagnostic_procedure:T34 T35 Lab_value 985 995 36 seconds E26 Lab_value:T35 R10 SUB_PROCEDURE Arg1:E25 Arg2:E22 R11 MODIFY Arg1:E26 Arg2:E25 T36 Diagnostic_procedure 999 1019 complete blood count E27 Diagnostic_procedure:T36 T37 Diagnostic_procedure 1029 1039 hemoglobin E28 Diagnostic_procedure:T37 T38 Lab_value 1043 1067 11.6 grams per deciliter E29 Lab_value:T38 R12 MODIFY Arg1:E29 Arg2:E28 T39 Diagnostic_procedure 1071 1081 hematocrit E30 Diagnostic_procedure:T39 T40 Lab_value 1085 1090 34.9% E31 Lab_value:T40 R13 MODIFY Arg1:E31 Arg2:E30 T41 Diagnostic_procedure 1104 1113 platelets E32 Diagnostic_procedure:T41 T42 Lab_value 1096 1103 281×103 E33 Lab_value:T42 T43 Detailed_description 1114 1128 per microliter R14 MODIFY Arg1:T43 Arg2:E32 R15 MODIFY Arg1:E33 Arg2:E32 R16 SUB_PROCEDURE Arg1:E28 Arg2:E27 R17 SUB_PROCEDURE Arg1:E30 Arg2:E27 R18 SUB_PROCEDURE Arg1:E32 Arg2:E27 T44 Diagnostic_procedure 1134 1153 blood urea nitrogen E34 Diagnostic_procedure:T44 T45 Lab_value 1158 1181 55 milligrams/deciliter E35 Lab_value:T45 T46 Diagnostic_procedure 1197 1207 creatinine E36 Diagnostic_procedure:T46 T47 Detailed_description 1191 1196 serum R19 MODIFY Arg1:T47 Arg2:E36 T48 Lab_value 1212 1237 5.22 milligrams/deciliter E37 Lab_value:T48 R20 MODIFY Arg1:E37 Arg2:E36 R21 MODIFY Arg1:E35 Arg2:E34 T49 Medication 1262 1269 aspirin E38 Medication:T49 T50 Dosage 1270 1283 81 mg per day R22 MODIFY Arg1:T50 Arg2:E38 T51 Therapeutic_procedure 1298 1313 cardiac surgery E39 Therapeutic_procedure:T51 T52 Medication 1334 1354 anticoagulant agents E40 Medication:T52 A3 POLARITY E40 NEG T53 History 1364 1402 did not have a history of coagulopathy T54 Disease_disorder 1390 1402 coagulopathy E41 Disease_disorder:T54 A4 POLARITY E41 NEG T55 Therapeutic_procedure 722 740 PEG tube insertion E42 Therapeutic_procedure:T55 A5 POLARITY E42 UNCERTAIN T56 Therapeutic_procedure 1404 1422 PEG tube insertion E43 Therapeutic_procedure:T56 T57 Medication 1483 1493 anesthesia E44 Medication:T57 T58 Administration 1471 1482 intravenous R23 MODIFY Arg1:T58 Arg2:E44 T59 Date 1455 1464 day eight E45 Date:T59 T60 Diagnostic_procedure 1499 1525 esophagogastroduodenoscopy E46 Diagnostic_procedure:T60 T61 Diagnostic_procedure 1527 1530 EGD E47 Diagnostic_procedure:T61 R24 IDENTICAL Arg1:E47 Arg2:E46 T62 Other_event 1557 1567 difficulty E48 Other_event:T62 A6 POLARITY E48 NEG T63 Sign_symptom 1626 1634 bleeding E49 Sign_symptom:T63 A7 POLARITY E49 NEG T64 Sign_symptom 1598 1610 erythematous E50 Sign_symptom:T64 T65 Severity 1587 1597 moderately R25 MODIFY Arg1:T65 Arg2:E50 T66 Detailed_description 1579 1586 diffuse R26 MODIFY Arg1:T66 Arg2:E50 T67 Biological_structure 1611 1617 mucosa R27 MODIFY Arg1:T67 Arg2:E50 R28 MODIFY Arg1:T67 Arg2:E49 T68 Biological_structure 1642 1656 gastric antrum R29 MODIFY Arg1:T68 Arg2:E49 R30 MODIFY Arg1:T68 Arg2:E50 T69 Sign_symptom 1715 1723 hematoma E51 Sign_symptom:T69 T70 Severity 1697 1714 rapidly expanding R31 MODIFY Arg1:T70 Arg2:E51 T71 Biological_structure 1752 1773 needle insertion site R32 MODIFY Arg1:T71 Arg2:E51 T72 Therapeutic_procedure 1675 1692 PEG tube placemen E52 Therapeutic_procedure:T72 A8 POLARITY E52 NEG T73 Coreference 1779 1788 procedure E53 Coreference:T73 R33 IDENTICAL Arg1:E53 Arg2:E52 T74 Clinical_event 1821 1830 sent back E54 Clinical_event:T74 T75 Nonbiological_location 1838 1841 ICU R34 MODIFY Arg1:T75 Arg2:E54 T76 Therapeutic_procedure 1849 1865 nasogastric tube E55 Therapeutic_procedure:T76 T77 Medication 1896 1908 desmopressin E56 Medication:T77 T78 Administration 1884 1895 intravenous T79 Dosage 1869 1880 single dose T80 Dosage 1910 1932 0.3 microgram/kilogram R35 MODIFY Arg1:T80 Arg2:E56 R36 MODIFY Arg1:T78 Arg2:E56 R37 MODIFY Arg1:T79 Arg2:E56 T81 Sign_symptom 1974 1989 uremic bleeding E57 Sign_symptom:T81 A9 POLARITY E57 UNCERTAIN T82 Sign_symptom 2019 2027 bleeding E58 Sign_symptom:T82 A10 POLARITY E58 NEG T83 Biological_structure 2002 2018 gastrointestinal R38 MODIFY Arg1:T83 Arg2:E58 T84 Diagnostic_procedure 2057 2074 platelet function E59 Diagnostic_procedure:T84 T85 Diagnostic_procedure 2078 2101 platelet function assay E60 Diagnostic_procedure:T85 R39 SUB_PROCEDURE Arg1:E60 Arg2:E59 T86 Diagnostic_procedure 2103 2106 PFA E61 Diagnostic_procedure:T86 R40 IDENTICAL Arg1:E61 Arg2:E60 T87 Medication 2126 2138 desmopressin E62 Medication:T87 T88 Administration 2139 2148 injection R41 MODIFY Arg1:T88 Arg2:E62 T89 Diagnostic_procedure 2150 2153 PFA E63 Diagnostic_procedure:T89 T90 Diagnostic_procedure 2154 2187 collagen/epinephrine closure time E64 Diagnostic_procedure:T90 R42 SUB_PROCEDURE Arg1:E64 Arg2:E63 T91 Diagnostic_procedure 2231 2256 collagen/ADP closure time E65 Diagnostic_procedure:T91 T92 Lab_value 2192 2203 195 seconds E66 Lab_value:T92 T93 Lab_value 2261 2271 76 seconds E67 Lab_value:T93 R43 MODIFY Arg1:E67 Arg2:E65 R44 MODIFY Arg1:E66 Arg2:E64 T94 Disease_disorder 2306 2326 platelet dysfunction E68 Disease_disorder:T94 T95 Medication 2341 2348 aspirin E69 Medication:T95 T96 Disease_disorder 2352 2358 uremia E70 Disease_disorder:T96 A11 POLARITY E2 NEG T97 Therapeutic_procedure 2397 2406 monitored E71 Therapeutic_procedure:T97 T98 Diagnostic_procedure 2420 2440 complete blood count E72 Diagnostic_procedure:T98 T99 Diagnostic_procedure 2445 2460 metabolic panel E73 Diagnostic_procedure:T99 T100 Frequency 2414 2419 daily R45 MODIFY Arg1:T100 Arg2:E72 R46 MODIFY Arg1:T100 Arg2:E73 T101 Date 2462 2478 Three days later E74 Date:T101 T102 Therapeutic_procedure 2521 2539 PEG tube placement E75 Therapeutic_procedure:T102 T103 Diagnostic_procedure 2541 2544 PFA E76 Diagnostic_procedure:T103 T104 Diagnostic_procedure 2545 2578 collagen/epinephrine closure time E77 Diagnostic_procedure:T104 R47 SUB_PROCEDURE Arg1:E77 Arg2:E76 T105 Coreference 2593 2602 procedure E78 Coreference:T105 R48 IDENTICAL Arg1:E78 Arg2:E75 T106 Lab_value 2607 2616 gone down E79 Lab_value:T106 T107 Lab_value 2620 2631 141 seconds E80 Lab_value:T107 R49 MODIFY Arg1:E79 Arg2:E77 R50 MODIFY Arg1:E80 Arg2:E77 T108 Medication 2661 2668 aspirin E81 Medication:T108 A12 POLARITY E81 NEG T109 Diagnostic_procedure 2691 2705 renal function E82 Diagnostic_procedure:T109 T110 Lab_value 2676 2687 improvement E83 Lab_value:T110 R51 MODIFY Arg1:E83 Arg2:E82 T111 Diagnostic_procedure 2707 2710 EGD E84 Diagnostic_procedure:T111 T112 Sign_symptom 2761 2769 bruising E85 Sign_symptom:T112 T113 Biological_structure 2742 2760 gastric submucosal T114 Color 2735 2741 bluish T115 Texture 2729 2733 flat R52 MODIFY Arg1:T113 Arg2:E85 R53 MODIFY Arg1:T114 Arg2:E85 R54 MODIFY Arg1:T115 Arg2:E85 T116 Sign_symptom 2798 2806 hematoma E86 Sign_symptom:T116 T117 Therapeutic_procedure 2823 2831 PEG tube E87 Therapeutic_procedure:T117 A13 POLARITY E75 UNCERTAIN T118 Biological_structure 2862 2875 adjacent site R55 MODIFY Arg1:T118 Arg2:E87 T119 Duration 2900 2915 following month E88 Duration:T119 T120 Therapeutic_procedure 2950 2957 feeding E89 Therapeutic_procedure:T120 T121 Therapeutic_procedure 2970 2978 PEG tube E90 Therapeutic_procedure:T121 T122 Sign_symptom 2987 3001 adverse events E91 Sign_symptom:T122 A14 POLARITY E91 NEG * OVERLAP E1 E3 T123 Clinical_event 123 131 admitted E92 Clinical_event:T123 R56 BEFORE Arg1:E3 Arg2:E92 * OVERLAP E92 E4 E5 R57 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E7 R58 BEFORE Arg1:E7 Arg2:E8 * OVERLAP E8 E9 E10 E11 R59 BEFORE Arg1:E11 Arg2:E12 T124 Nonbiological_location 555 558 ICU T125 Clinical_event 559 568 admission E93 Clinical_event:T125 R60 MODIFY Arg1:T124 Arg2:E93 * OVERLAP E12 E93 E13 E14 E15 E16 E17 E42 E18 E19 E22 E27 E34 E36 E38 R61 AFTER Arg1:E38 Arg2:E39 R62 BEFORE Arg1:E39 Arg2:E40 R63 AFTER Arg1:E40 Arg2:E41 R64 BEFORE Arg1:E41 Arg2:E43 * OVERLAP E43 E45 E44 E46 E48 E50 E49 E52 E51 E53 R65 BEFORE Arg1:E53 Arg2:E54 * OVERLAP E54 E55 R66 BEFORE Arg1:E55 Arg2:E56 * OVERLAP E56 E57 E58 E59 R67 AFTER Arg1:E59 Arg2:E62 R68 BEFORE Arg1:E62 Arg2:E63 R69 SUB_PROCEDURE Arg1:E65 Arg2:E63 * OVERLAP E63 E68 E69 E70 R70 BEFORE Arg1:E70 Arg2:E2 * OVERLAP E2 E71 E72 E73 R71 BEFORE Arg1:E73 Arg2:E74 * OVERLAP E74 E75 R72 AFTER Arg1:E75 Arg2:E76 * OVERLAP E76 E81 E82 R73 BEFORE Arg1:E82 Arg2:E84 * OVERLAP E84 E85 R74 AFTER Arg1:E85 Arg2:E86 R75 BEFORE Arg1:E86 Arg2:E87 R76 BEFORE Arg1:E87 Arg2:E88 * OVERLAP E88 E89 E90 E91