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T1 Sex 2 8 female T3 Clinical_event 45 52 visited E1 Clinical_event:T3 T4 Nonbiological_location 57 65 hospital R1 MODIFY Arg1:T4 Arg2:E1 T5 Disease_disorder 77 92 liver cirrhosis E2 Disease_disorder:T5 T6 Disease_disorder 108 125 hepatitis B virus E3 Disease_disorder:T6 T7 Disease_disorder 130 149 biliary duct stones E4 Disease_disorder:T7 R2 CAUSE Arg1:E3 Arg2:E2 R3 CAUSE Arg1:E4 Arg2:E2 T2 History 77 92 liver cirrhosis T8 Date 23 30 her 50s E5 Date:T8 #1 AnnotatorNotes E5 NOT patient's age in context of case report! T9 Age 154 169 65 years of age T10 Disease_disorder 189 192 HCC E6 Disease_disorder:T10 #2 AnnotatorNotes E6 Hepatocellular carcinoma T11 Lab_value 198 216 BCLC early stage A #3 AnnotatorNotes T11 Barcelona clinic liver cancer staging R4 MODIFY Arg1:T11 Arg2:E6 T12 Diagnostic_procedure 222 236 liver function E7 Diagnostic_procedure:T12 T13 Lab_value 241 255 well preserved R5 MODIFY Arg1:T13 Arg2:E7 T14 Diagnostic_procedure 261 277 Child-Pugh score E8 Diagnostic_procedure:T14 T15 Lab_value 282 283 A R6 MODIFY Arg1:T15 Arg2:E8 T16 Therapeutic_procedure 312 325 segmentectomy E9 Therapeutic_procedure:T16 T17 Detailed_description 299 311 left lateral R7 MODIFY Arg1:T17 Arg2:E9 T18 Disease_disorder 330 333 HCC E10 Disease_disorder:T18 T19 Therapeutic_procedure 343 372 other preoperative treatments E11 Therapeutic_procedure:T19 A1 POLARITY E11 NEG T20 Diagnostic_procedure 374 400 Histopathological findings E12 Diagnostic_procedure:T20 T21 Disease_disorder 432 454 pseudolobule formation E13 Disease_disorder:T21 T22 Disease_disorder 419 427 fibrosis E14 Disease_disorder:T22 T23 Detailed_description 410 418 bridging R8 MODIFY Arg1:T23 Arg2:E14 T24 Diagnostic_procedure 472 489 alpha-fetoprotein E15 Diagnostic_procedure:T24 T25 Diagnostic_procedure 491 494 AFP E16 Diagnostic_procedure:T25 R9 IDENTICAL Arg1:E16 Arg2:E15 T26 Biological_structure 456 461 Serum R10 MODIFY Arg1:T26 Arg2:E15 T27 Diagnostic_procedure 500 539 protein induced by vitamin K absence-II E17 Diagnostic_procedure:T27 T28 Lab_value 540 550 normalized R11 MODIFY Arg1:T28 Arg2:E17 R12 MODIFY Arg1:T28 Arg2:E15 R13 MODIFY Arg1:T26 Arg2:E17 T29 Coreference 565 574 resection E18 Coreference:T29 R14 IDENTICAL Arg1:E18 Arg2:E9 T30 Sign_symptom 613 623 metastasis E19 Sign_symptom:T30 T31 Diagnostic_procedure 590 605 imaging studies E20 Diagnostic_procedure:T31 T32 Biological_structure 610 612 LN #4 AnnotatorNotes T32 lymph node R15 MODIFY Arg1:T32 Arg2:E19 T33 Coreference 660 669 resection E21 Coreference:T33 R16 IDENTICAL Arg1:E21 Arg2:E18 T34 Date 678 698 Two and a half years E22 Date:T34 T35 Diagnostic_procedure 730 739 AFP level E23 Diagnostic_procedure:T35 T36 Lab_value 740 762 increased dramatically R17 MODIFY Arg1:T36 Arg2:E23 T37 Lab_value 766 777 780.2 ng/ml R18 MODIFY Arg1:T37 Arg2:E23 T38 Sign_symptom 789 795 lesion E24 Sign_symptom:T38 T39 Shape 781 788 lobular R19 MODIFY Arg1:T39 Arg2:E24 T40 Diagnostic_procedure 852 878 magnetic resonance imaging E25 Diagnostic_procedure:T40 T41 Detailed_description 834 851 contrast-enhanced R20 MODIFY Arg1:T41 Arg2:E25 T42 Detailed_description 801 817 fine enhancement R21 MODIFY Arg1:T42 Arg2:E24 T43 Coreference 884 889 tumor E26 Coreference:T43 R22 IDENTICAL Arg1:E26 Arg2:E24 T44 Distance 899 916 27 mm in diameter R23 MODIFY Arg1:T44 Arg2:E26 T45 Biological_structure 933 960 caudally on the left kidney R24 MODIFY Arg1:T45 Arg2:E26 T46 Diagnostic_procedure 983 1002 computed tomography E27 Diagnostic_procedure:T46 T47 Detailed_description 965 982 contrast-enhanced R25 MODIFY Arg1:T47 Arg2:E27 T48 Coreference 1008 1013 tumor E28 Coreference:T48 R26 IDENTICAL Arg1:E28 Arg2:E26 T49 Sign_symptom 1028 1039 enhancement E29 Sign_symptom:T49 T50 Detailed_description 1021 1027 strong R27 MODIFY Arg1:T50 Arg2:E29 T51 Biological_structure 1047 1061 arterial phase R28 MODIFY Arg1:T51 Arg2:E29 T52 Sign_symptom 1099 1106 density E30 Sign_symptom:T52 T53 Detailed_description 1084 1098 relatively low R29 MODIFY Arg1:T53 Arg2:E30 T54 Biological_structure 1114 1126 portal phase R30 MODIFY Arg1:T54 Arg2:E30 T55 Disease_disorder 1206 1209 HCC E31 Disease_disorder:T55 T56 Detailed_description 1198 1205 typical R31 MODIFY Arg1:T56 Arg2:E31 T57 Diagnostic_procedure 1445 1470 Three-dimensional imaging E32 Diagnostic_procedure:T57 T58 Coreference 1487 1492 tumor E33 Coreference:T58 R32 IDENTICAL Arg1:E33 Arg2:E28 T59 Biological_structure 1497 1553 fed by a main vessel from the inferior mesenteric artery R33 MODIFY Arg1:T59 Arg2:E33 T60 Biological_structure 1576 1628 accessory feeder from the superior mesenteric artery R34 MODIFY Arg1:T60 Arg2:E33 T61 Diagnostic_procedure 1641 1700 Fluorine-18-fluorodeoxyglucose positron emission tomography E34 Diagnostic_procedure:T61 T62 Diagnostic_procedure 1702 1709 FDG-PET E35 Diagnostic_procedure:T62 R35 IDENTICAL Arg1:E35 Arg2:E34 T63 Diagnostic_procedure 1715 1763 positron emission tomography-computed tomography E36 Diagnostic_procedure:T63 T64 Sign_symptom 1991 2001 metastasis E37 Sign_symptom:T64 A2 POLARITY E37 NEG T65 Biological_structure 1978 1990 extrahepatic T66 Biological_structure 1962 1974 intrahepatic R36 MODIFY Arg1:T65 Arg2:E37 R37 MODIFY Arg1:T66 Arg2:E37 T67 Sign_symptom 2068 2078 metastasis E38 Sign_symptom:T67 T68 Detailed_description 2059 2067 solitary R38 MODIFY Arg1:T68 Arg2:E38 T69 Biological_structure 2084 2096 mesocolic LN R39 MODIFY Arg1:T69 Arg2:E38 T70 Disease_disorder 2100 2103 HCC E39 Disease_disorder:T70 T71 Detailed_description 2104 2117 dissemination R40 MODIFY Arg1:T71 Arg2:E39 T72 Sign_symptom 2286 2291 tumor E40 Sign_symptom:T72 T73 Detailed_description 2296 2304 solitary R41 MODIFY Arg1:T73 Arg2:E40 T74 Sign_symptom 2334 2344 metastases E41 Sign_symptom:T74 A3 POLARITY E41 NEG T75 Detailed_description 2328 2333 other R42 MODIFY Arg1:T75 Arg2:E41 T76 Therapeutic_procedure 2419 2437 surgical resection E42 Therapeutic_procedure:T76 T77 Sign_symptom 2455 2476 disseminative nodules E43 Sign_symptom:T77 A4 POLARITY E43 NEG T78 Disease_disorder 2478 2493 lymphadenopathy E44 Disease_disorder:T78 A5 POLARITY E44 NEG T79 Sign_symptom 2498 2505 ascites E45 Sign_symptom:T79 A6 POLARITY E45 NEG T80 Coreference 2539 2544 tumor E46 Coreference:T80 R43 IDENTICAL Arg1:E46 Arg2:E40 T81 Biological_structure 2564 2573 mesocolon R44 MODIFY Arg1:T81 Arg2:E46 T82 Biological_structure 2581 2616 at the wall of the descending colon R45 MODIFY Arg1:T82 Arg2:E46 T83 Coreference 2630 2639 resection E47 Coreference:T83 R46 IDENTICAL Arg1:E47 Arg2:E42 T84 Biological_structure 2647 2663 descending colon R47 MODIFY Arg1:T84 Arg2:E47 T85 Biological_structure 2669 2687 regional mesocolon R48 MODIFY Arg1:T85 Arg2:E47 T86 Therapeutic_procedure 2717 2737 postoperative course E48 Therapeutic_procedure:T86 T87 Lab_value 2742 2752 uneventful R49 MODIFY Arg1:T87 Arg2:E48 T88 Clinical_event 2766 2776 discharged E49 Clinical_event:T88 T89 Date 2794 2799 day 8 E50 Date:T89 T90 Diagnostic_procedure 2817 2829 tumor marker E51 Diagnostic_procedure:T90 T91 Biological_structure 2801 2806 Serum R50 MODIFY Arg1:T91 Arg2:E51 T92 Lab_value 2830 2851 decreased immediately R51 MODIFY Arg1:T92 Arg2:E51 T93 Diagnostic_procedure 2878 2893 Macroscopically E52 Diagnostic_procedure:T93 T94 Coreference 2899 2914 mesocolic tumor E53 Coreference:T94 R52 IDENTICAL Arg1:E53 Arg2:E46 T95 Lab_value 2921 2926 solid T96 Lab_value 2931 2938 elastic T97 Texture 2951 2965 smooth surface R53 MODIFY Arg1:T95 Arg2:E53 R54 MODIFY Arg1:T96 Arg2:E53 R55 MODIFY Arg1:T97 Arg2:E53 T98 Sign_symptom 2991 2997 nodule E54 Sign_symptom:T98 T99 Color 2981 2990 yellowish R56 MODIFY Arg1:T99 Arg2:E54 T100 Detailed_description 3002 3033 encapsulated in the cut surface R57 MODIFY Arg1:T100 Arg2:E54 T101 Disease_disorder 3084 3087 HCC E55 Disease_disorder:T101 T102 Detailed_description 3095 3111 ductal structure R58 MODIFY Arg1:T102 Arg2:E55 T103 Detailed_description 3073 3083 metastatic R59 MODIFY Arg1:T103 Arg2:E55 T104 Detailed_description 3051 3062 enlarged LN R60 MODIFY Arg1:T104 Arg2:E55 T105 Diagnostic_procedure 3129 3150 immunohistochemically E56 Diagnostic_procedure:T105 T106 Diagnostic_procedure 3179 3182 AFP E57 Diagnostic_procedure:T106 T107 Lab_value 3166 3174 positive R61 MODIFY Arg1:T107 Arg2:E57 T108 Diagnostic_procedure 3200 3205 CK-20 E58 Diagnostic_procedure:T108 T109 Lab_value 3187 3195 negative R62 MODIFY Arg1:T109 Arg2:E58 T110 Disease_disorder 3256 3259 HCC E59 Disease_disorder:T110 T111 Detailed_description 3248 3255 primary R63 MODIFY Arg1:T111 Arg2:E59 R64 SUB_PROCEDURE Arg1:E58 Arg2:E56 R65 SUB_PROCEDURE Arg1:E57 Arg2:E56 T112 Disease_disorder 3320 3323 HCC E60 Disease_disorder:T112 T113 Detailed_description 3309 3319 metastatic R66 MODIFY Arg1:T113 Arg2:E60 T114 Biological_structure 3329 3341 mesocolic LN R67 MODIFY Arg1:T114 Arg2:E60 T115 Sign_symptom 3410 3420 recurrence E61 Sign_symptom:T115 A7 POLARITY E61 NEG T116 Date 3425 3440 13 months after E62 Date:T116 T117 Clinical_event 3489 3500 followed up E63 Clinical_event:T117 T118 Medication 3505 3523 adjuvant therapies E64 Medication:T118 A8 POLARITY E64 NEG * OVERLAP E1 E2 E3 E4 R68 BEFORE Arg1:E4 Arg2:E6 * OVERLAP E6 E7 E8 R69 BEFORE Arg1:E8 Arg2:E9 * OVERLAP E9 E10 E11 E12 E14 E13 R70 BEFORE Arg1:E13 Arg2:E15 * OVERLAP E15 E17 E18 E20 E19 E21 R71 BEFORE Arg1:E21 Arg2:E22 * OVERLAP E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E34 E36 E37 E38 E39 E40 E41 R72 BEFORE Arg1:E41 Arg2:E42 * OVERLAP E42 E43 E44 E45 E65 E46 E47 T119 Coreference 2526 2533 surgery E65 Coreference:T119 R73 IDENTICAL Arg1:E65 Arg2:E42 R74 BEFORE Arg1:E47 Arg2:E48 R75 BEFORE Arg1:E48 Arg2:E49 * OVERLAP E49 E50 R76 AFTER Arg1:E50 Arg2:E51 T120 Coreference 2858 2865 surgery E66 Coreference:T120 R77 IDENTICAL Arg1:E66 Arg2:E65 * OVERLAP E51 E52 E53 E54 E55 E56 E59 E60 R78 BEFORE Arg1:E60 Arg2:E61 * OVERLAP E61 E62 E63 E64 T121 History 108 125 hepatitis B virus T122 History 130 149 biliary duct stones