--- a
+++ b/processing/MACCROBAT/27846860.ann
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+T1	Age 2 13	20-year-old
+T2	History 14 32	previously healthy
+T3	Personal_background 33 40	Bengali
+T4	Sex 41 44	man
+T5	Clinical_event 45 54	presented
+E1	Clinical_event:T5 
+T6	Nonbiological_location 62 70	hospital
+R1	MODIFY Arg1:T6 Arg2:E1	
+T7	Sign_symptom 76 82	anuria
+E2	Sign_symptom:T7 
+T8	Disease_disorder 106 120	encephalopathy
+E3	Disease_disorder:T8 
+A1	POLARITY E3 MAYBE_POS
+T9	Detailed_description 99 105	uremic
+R2	MODIFY Arg1:T9 Arg2:E3	
+T10	Sign_symptom 569 584	acidotic breath
+E4	Sign_symptom:T10 
+T11	Sign_symptom 553 563	tachypneic
+E5	Sign_symptom:T11 
+T12	Date 122 136	Ten days prior
+E6	Date:T12 
+T13	Sign_symptom 201 205	pain
+E7	Sign_symptom:T13 
+T14	Biological_structure 185 200	upper abdominal
+T15	Severity 178 184	severe
+R3	MODIFY Arg1:T14 Arg2:E7	
+R4	MODIFY Arg1:T15 Arg2:E7	
+T16	Sign_symptom 210 218	vomiting
+E8	Sign_symptom:T16 
+T17	Therapeutic_procedure 236 243	treated
+E9	Therapeutic_procedure:T17 
+T18	Nonbiological_location 249 270	primary care facility
+R5	MODIFY Arg1:T18 Arg2:E9	
+T19	Disease_disorder 298 310	pancreatitis
+E10	Disease_disorder:T19 
+A2	POLARITY E10 MAYBE_POS
+T20	Detailed_description 292 297	acute
+R6	MODIFY Arg1:T20 Arg2:E10	
+T21	Sign_symptom 316 332	initial symptoms
+E11	Sign_symptom:T21 
+A3	TREND E11 DEC
+T22	Sign_symptom 372 378	anuric
+E12	Sign_symptom:T22 
+T23	Sign_symptom 383 394	disoriented
+E13	Sign_symptom:T23 
+T24	Clinical_event 408 419	transferred
+E14	Clinical_event:T24 
+T25	Nonbiological_location 427 435	hospital
+R7	MODIFY Arg1:T25 Arg2:E14	
+T26	Clinical_event 463 475	presentation
+E15	Clinical_event:T26 
+T27	Sign_symptom 509 517	agitated
+E16	Sign_symptom:T27 
+T28	Sign_symptom 519 527	restless
+E17	Sign_symptom:T28 
+T29	Sign_symptom 533 544	disoriented
+E18	Sign_symptom:T29 
+T30	Severity 500 508	severely
+R8	MODIFY Arg1:T30 Arg2:E16	
+R9	MODIFY Arg1:T30 Arg2:E17	
+R10	MODIFY Arg1:T30 Arg2:E18	
+T31	Sign_symptom 597 602	edema
+E19	Sign_symptom:T31 
+T32	Biological_structure 591 596	pedal
+R11	MODIFY Arg1:T32 Arg2:E19	
+T33	Severity 586 590	Mild
+R12	MODIFY Arg1:T33 Arg2:E19	
+T34	Diagnostic_procedure 629 652	jugular venous pressure
+E20	Diagnostic_procedure:T34 
+T35	Lab_value 657 667	not raised
+R13	MODIFY Arg1:T35 Arg2:E20	
+T36	Diagnostic_procedure 673 678	pulse
+E21	Diagnostic_procedure:T36 
+T37	Lab_value 683 699	112 beats/minute
+R14	MODIFY Arg1:T37 Arg2:E21	
+T38	Diagnostic_procedure 705 719	blood pressure
+E22	Diagnostic_procedure:T38 
+T39	Lab_value 724 735	140/90 mmHg
+R15	MODIFY Arg1:T39 Arg2:E22	
+T40	Diagnostic_procedure 745 761	body temperature
+E23	Diagnostic_procedure:T40 
+T41	Lab_value 766 771	98 °F
+R16	MODIFY Arg1:T41 Arg2:E23	
+T42	Sign_symptom 792 802	irritation
+E24	Sign_symptom:T42 
+A4	POLARITY E24 NEG
+T43	Biological_structure 782 791	meningeal
+R17	MODIFY Arg1:T43 Arg2:E24	
+T44	Diagnostic_procedure 824 840	plantar response
+E25	Diagnostic_procedure:T44 
+T45	Lab_value 845 865	bilaterally extensor
+R18	MODIFY Arg1:T45 Arg2:E25	
+T46	Diagnostic_procedure 906 917	examination
+E26	Diagnostic_procedure:T46 
+T47	Biological_structure 925 938	other systems
+R19	MODIFY Arg1:T47 Arg2:E26	
+T48	Lab_value 943 955	unremarkable
+R20	MODIFY Arg1:T48 Arg2:E26	
+T49	Diagnostic_procedure 871 877	fundus
+E27	Diagnostic_procedure:T49 
+T50	Lab_value 878 900	could not be evaluated
+R21	MODIFY Arg1:T50 Arg2:E27	
+T51	Diagnostic_procedure 961 982	laboratory parameters
+E28	Diagnostic_procedure:T51 
+T52	Disease_disorder 1002 1019	renal dysfunction
+E29	Disease_disorder:T52 
+T53	Diagnostic_procedure 1021 1037	serum creatinine
+E30	Diagnostic_procedure:T53 
+R22	SUB_PROCEDURE Arg1:E30 Arg2:E28	
+T54	Lab_value 1038 1046	13 mg/dl
+R23	MODIFY Arg1:T54 Arg2:E30	
+T55	Diagnostic_procedure 1048 1058	serum urea
+E31	Diagnostic_procedure:T55 
+T56	Lab_value 1059 1068	293 mg/dl
+R24	MODIFY Arg1:T56 Arg2:E31	
+T57	Lab_value 1071 1077	raised
+T58	Diagnostic_procedure 1078 1096	pancreatic enzymes
+E32	Diagnostic_procedure:T58 
+R25	MODIFY Arg1:T57 Arg2:E32	
+R26	SUB_PROCEDURE Arg1:E31 Arg2:E28	
+R27	SUB_PROCEDURE Arg1:E32 Arg2:E28	
+T59	Diagnostic_procedure 1098 1111	serum amylase
+E33	Diagnostic_procedure:T59 
+T60	Lab_value 1112 1119	249 U/L
+R28	MODIFY Arg1:T60 Arg2:E33	
+R29	SUB_PROCEDURE Arg1:E33 Arg2:E32	
+T61	Diagnostic_procedure 1147 1159	serum lipase
+E34	Diagnostic_procedure:T61 
+T62	Lab_value 1160 1167	227 U/L
+R30	MODIFY Arg1:T62 Arg2:E34	
+R31	SUB_PROCEDURE Arg1:E34 Arg2:E32	
+T63	Diagnostic_procedure 1198 1212	liver function
+E35	Diagnostic_procedure:T63 
+T64	Lab_value 1191 1197	normal
+R32	MODIFY Arg1:T64 Arg2:E35	
+R33	SUB_PROCEDURE Arg1:E35 Arg2:E28	
+T65	Diagnostic_procedure 1220 1235	serum bilirubin
+E36	Diagnostic_procedure:T65 
+T66	Lab_value 1236 1245	0.9 mg/dl
+R34	MODIFY Arg1:T66 Arg2:E36	
+R35	SUB_PROCEDURE Arg1:E36 Arg2:E35	
+T67	Diagnostic_procedure 1247 1271	alanine aminotransferase
+E37	Diagnostic_procedure:T67 
+R36	SUB_PROCEDURE Arg1:E37 Arg2:E35	
+T68	Lab_value 1272 1278	38 U/L
+R37	MODIFY Arg1:T68 Arg2:E37	
+T69	Diagnostic_procedure 1280 1306	aspartate aminotransferase
+E38	Diagnostic_procedure:T69 
+T70	Lab_value 1307 1313	35 U/L
+R38	MODIFY Arg1:T70 Arg2:E38	
+R39	SUB_PROCEDURE Arg1:E38 Arg2:E35	
+T71	Diagnostic_procedure 1315 1335	alkaline phosphatase
+E39	Diagnostic_procedure:T71 
+T72	Lab_value 1336 1343	122 U/L
+R40	MODIFY Arg1:T72 Arg2:E39	
+R41	SUB_PROCEDURE Arg1:E39 Arg2:E35	
+T73	Diagnostic_procedure 1345 1358	serum albumin
+E40	Diagnostic_procedure:T73 
+T74	Lab_value 1359 1365	37 g/L
+R42	MODIFY Arg1:T74 Arg2:E40	
+R43	SUB_PROCEDURE Arg1:E40 Arg2:E35	
+T75	Diagnostic_procedure 1375 1384	potassium
+E41	Diagnostic_procedure:T75 
+T76	Lab_value 1368 1374	normal
+R44	MODIFY Arg1:T76 Arg2:E41	
+R45	SUB_PROCEDURE Arg1:E41 Arg2:E28	
+T77	Lab_value 1386 1396	5.1 mmol/L
+R46	MODIFY Arg1:T77 Arg2:E41	
+T78	Lab_value 1399 1405	normal
+T79	Diagnostic_procedure 1406 1417	bicarbonate
+E42	Diagnostic_procedure:T79 
+T80	Lab_value 1419 1428	19 mmol/L
+R47	MODIFY Arg1:T80 Arg2:E42	
+R48	MODIFY Arg1:T78 Arg2:E42	
+T81	Lab_value 1435 1441	normal
+T82	Diagnostic_procedure 1442 1455	triglycerides
+E43	Diagnostic_procedure:T82 
+T83	Lab_value 1457 1466	173 mg/dl
+R49	MODIFY Arg1:T83 Arg2:E43	
+R50	MODIFY Arg1:T81 Arg2:E43	
+R51	SUB_PROCEDURE Arg1:E42 Arg2:E28	
+R52	SUB_PROCEDURE Arg1:E43 Arg2:E28	
+T84	Diagnostic_procedure 1473 1492	serological markers
+E44	Diagnostic_procedure:T84 
+T85	Diagnostic_procedure 1504 1526	antinuclear antibodies
+E45	Diagnostic_procedure:T85 
+R53	SUB_PROCEDURE Arg1:E45 Arg2:E44	
+T86	Diagnostic_procedure 1528 1577	cytoplasmic antineutrophil cytoplasmic antibodies
+E46	Diagnostic_procedure:T86 
+T87	Diagnostic_procedure 1579 1628	perinuclear antineutrophil cytoplasmic antibodies
+E47	Diagnostic_procedure:T87 
+T88	Diagnostic_procedure 1630 1632	C3
+E48	Diagnostic_procedure:T88 
+T89	Diagnostic_procedure 1638 1640	C4
+E49	Diagnostic_procedure:T89 
+R54	SUB_PROCEDURE Arg1:E46 Arg2:E44	
+R55	SUB_PROCEDURE Arg1:E47 Arg2:E44	
+R56	SUB_PROCEDURE Arg1:E48 Arg2:E44	
+R57	SUB_PROCEDURE Arg1:E49 Arg2:E44	
+T90	Lab_value 1647 1667	within normal limits
+R58	MODIFY Arg1:T90 Arg2:E44	
+T91	Diagnostic_procedure 1672 1685	ultrasonogram
+E50	Diagnostic_procedure:T91 
+T92	Biological_structure 1699 1706	abdomen
+R59	MODIFY Arg1:T92 Arg2:E50	
+T93	Lab_value 1711 1723	unremarkable
+R60	MODIFY Arg1:T93 Arg2:E50	
+T94	Diagnostic_procedure 1751 1770	computed tomography
+E51	Diagnostic_procedure:T94 
+T95	Diagnostic_procedure 1772 1774	CT
+E52	Diagnostic_procedure:T95 
+R61	IDENTICAL Arg1:E52 Arg2:E51	
+T96	Detailed_description 1729 1750	non-contrast-enhanced
+R62	MODIFY Arg1:T96 Arg2:E51	
+T97	Disease_disorder 1810 1822	pancreatitis
+E53	Disease_disorder:T97 
+A5	POLARITY E53 MAYBE_POS
+T98	Detailed_description 1804 1809	acute
+R63	MODIFY Arg1:T98 Arg2:E53	
+T99	Diagnostic_procedure 1836 1843	kidneys
+E54	Diagnostic_procedure:T99 
+T100	Lab_value 1849 1861	unremarkable
+R64	MODIFY Arg1:T100 Arg2:E54	
+T101	Disease_disorder 1916 1919	AKI
+E55	Disease_disorder:T101 
+#1	AnnotatorNotes E55	acute kidney injury
+T102	Disease_disorder 1930 1942	pancreatitis
+E56	Disease_disorder:T102 
+T103	Detailed_description 1924 1929	acute
+R65	MODIFY Arg1:T103 Arg2:E56	
+T104	Therapeutic_procedure 1951 1963	hemodialysis
+E57	Therapeutic_procedure:T104 
+T105	Detailed_description 1944 1950	Urgent
+R66	MODIFY Arg1:T105 Arg2:E57	
+T106	Therapeutic_procedure 2017 2029	hemodialysis
+E58	Therapeutic_procedure:T106 
+T107	Detailed_description 2001 2013	two sessions
+R67	MODIFY Arg1:T107 Arg2:E58	
+T108	Diagnostic_procedure 2035 2057	level of consciousness
+E59	Diagnostic_procedure:T108 
+T109	Lab_value 2058 2066	improved
+R68	MODIFY Arg1:T109 Arg2:E59	
+T110	Disease_disorder 2098 2109	visual loss
+E60	Disease_disorder:T110 
+T111	Severity 2089 2097	profound
+R69	MODIFY Arg1:T111 Arg2:E60	
+T112	Sign_symptom 2139 2158	perception of light
+E61	Sign_symptom:T112 
+T113	Diagnostic_procedure 2162 2185	funduscopic examination
+E62	Diagnostic_procedure:T113 
+T114	Sign_symptom 2193 2210	retinal whitening
+E63	Sign_symptom:T114 
+T115	Sign_symptom 2225 2244	cotton wool exudate
+E64	Sign_symptom:T115 
+T116	Severity 2215 2224	extensive
+R70	MODIFY Arg1:T116 Arg2:E64	
+T117	Sign_symptom 2257 2276	Purtscher’s flecken
+E65	Sign_symptom:T117 
+T118	Disease_disorder 2301 2324	Purtscher’s retinopathy
+E66	Disease_disorder:T118 
+T119	Medication 2347 2365	methylprednisolone
+E67	Medication:T119 
+T120	Dosage 2385 2395	once daily
+T121	Dosage 2367 2370	1 g
+T122	Administration 2371 2384	intravenously
+R71	MODIFY Arg1:T121 Arg2:E67	
+R72	MODIFY Arg1:T120 Arg2:E67	
+R73	MODIFY Arg1:T122 Arg2:E67	
+T123	Administration 2336 2346	parenteral
+R74	MODIFY Arg1:T123 Arg2:E67	
+T124	Dosage 2326 2335	High-dose
+R75	MODIFY Arg1:T124 Arg2:E67	
+T125	Duration 2400 2406	3 days
+E68	Duration:T125 
+T126	Diagnostic_procedure 2430 2461	evaluation of renal dysfunction
+E69	Diagnostic_procedure:T126 
+T127	Diagnostic_procedure 2471 2477	biopsy
+E70	Diagnostic_procedure:T127 
+T128	Biological_structure 2465 2470	renal
+R76	MODIFY Arg1:T128 Arg2:E70	
+T129	Diagnostic_procedure 2492 2518	histopathological findings
+E71	Diagnostic_procedure:T129 
+T130	Disease_disorder 2540 2563	renal cortical necrosis
+E72	Disease_disorder:T130 
+T131	History 2585 2628	denied substance abuse or alcohol ingestion
+T132	History 2633 2708	did not consume any nephrotoxic drugs or herbal products in the recent past
+T133	History 2710 2772	No history suggesting connective tissue diseases was available
+T134	Sign_symptom 2803 2814	hypotension
+E73	Sign_symptom:T134 
+A6	POLARITY E73 NEG
+T135	Disease_disorder 2906 2918	pancreatitis
+E74	Disease_disorder:T135 
+T136	Detailed_description 2900 2905	acute
+R77	MODIFY Arg1:T136 Arg2:E74	
+T137	Disease_disorder 2936 2959	renal cortical necrosis
+E75	Disease_disorder:T137 
+T138	Disease_disorder 2971 2974	AKI
+E76	Disease_disorder:T138 
+T139	Disease_disorder 2979 3002	Purtscher’s retinopathy
+E77	Disease_disorder:T139 
+T140	Disease_disorder 3033 3042	blindness
+E78	Disease_disorder:T140 
+T141	Detailed_description 3023 3032	bilateral
+T142	Severity 3014 3022	complete
+R78	MODIFY Arg1:T142 Arg2:E78	
+R79	MODIFY Arg1:T141 Arg2:E78	
+R80	CAUSE Arg1:E75 Arg2:E76	
+R81	CAUSE Arg1:E77 Arg2:E78	
+T143	Outcome 3047 3051	died
+E79	Outcome:T143 
+T144	Date 3052 3067	16 months after
+E80	Date:T144 
+T145	Disease_disorder 3136 3148	pancreatitis
+E81	Disease_disorder:T145 
+T146	Detailed_description 3130 3135	acute
+R82	MODIFY Arg1:T146 Arg2:E81	
+T147	Detailed_description 3110 3119	recurrent
+R83	MODIFY Arg1:T147 Arg2:E81	
+R84	CAUSE Arg1:E81 Arg2:E79	
+T148	Therapeutic_procedure 3198 3210	hemodialysis
+E82	Therapeutic_procedure:T148 
+T149	Detailed_description 3186 3197	maintenance
+R85	MODIFY Arg1:T149 Arg2:E82	
+T150	Diagnostic_procedure 3225 3239	renal function
+E83	Diagnostic_procedure:T150 
+T151	Lab_value 3240 3255	did not recover
+R86	MODIFY Arg1:T151 Arg2:E83	
+T152	Diagnostic_procedure 3291 3306	finger-counting
+E84	Diagnostic_procedure:T152 
+T153	Lab_value 3310 3316	2 feet
+R87	MODIFY Arg1:T153 Arg2:E84	
+T154	Diagnostic_procedure 3268 3274	vision
+E85	Diagnostic_procedure:T154 
+T155	Lab_value 3279 3287	improved
+R88	MODIFY Arg1:T155 Arg2:E85	
+R89	SUB_PROCEDURE Arg1:E84 Arg2:E85	
+*	OVERLAP E1 E2 E3
+R90	AFTER Arg1:E3 Arg2:E6	
+*	OVERLAP E6 E7 E8
+R91	BEFORE Arg1:E8 Arg2:E9	
+*	OVERLAP E9 E10
+R92	BEFORE Arg1:E10 Arg2:E11	
+*	OVERLAP E11 E12 E13
+R93	BEFORE Arg1:E13 Arg2:E14	
+R94	BEFORE Arg1:E14 Arg2:E15	
+*	OVERLAP E15 E16 E17 E18 E5 E4 E19 E20 E21 E22 E23 E24 E25 E27 E26 E28 E44 E50 E51 E53 E54 E55 E56
+R95	BEFORE Arg1:E56 Arg2:E57	
+R96	BEFORE Arg1:E57 Arg2:E58	
+*	OVERLAP E58 E59 E60 E61 E62 E63 E64 E65 E66
+R97	BEFORE Arg1:E66 Arg2:E67	
+*	OVERLAP E67 E68 E69 E70 E71 E72 E73
+R98	BEFORE Arg1:E73 Arg2:E74	
+*	OVERLAP E74 E75 E76 E77 E78
+R99	BEFORE Arg1:E78 Arg2:E79	
+*	OVERLAP E79 E80 E81
+R100	AFTER Arg1:E81 Arg2:E82	
+*	OVERLAP E82 E83 E85